Digital Commons Network^™

Amoebic Liver Abscess: A Disease Native To Oman?, Nenad Pandak, Sirous Golchinheydari, Asmaa S. Mahdi, Ali Al Majrafi, Stephen S. Deenadayalan, Faryal Khamis

Sultan Qaboos University Medical Journal

Objectives: Amoebic liver abscess (ALA) is endemic to many areas of the world. This study sought to investigate the epidemiology, presentation, laboratory tests and imaging characteristics of ALA in Oman and ultimately determine whether it is native to Oman or originated abroad. Methods: This case series study was conducted at the Royal Hospital, Muscat, Oman, from January 2013 to December 2017 with patients older than 13 years and having a discharge diagnosis of ALA. Patient data were extracted from the Royal Hospital patient database. Results: 22 patients were included in the study—18 Omani patients and four expatriates. Only two Omanis …

Evaluation Of Mrna-1273 Covid-19 Vaccine In Children 6 To 11 Years Of Age, C Buddy Creech, Evan Anderson, Vladimir Berthaud, Inci Yildirim, Andrew M. Atz, Ivan Melendez Baez, Daniel Finkelstein, Paul Pickrell, Judith Kirstein, Clifford Yut, Ronald Blair, Robert A. Clifford, Michael Dunn, James D. Campbell, David C. Montefiori, Joanne E. Tomassini, Xiaoping Zhao, Weiping Deng, Honghong Zhou, Daniela Ramirez Schrempp, Kelly Hautzinger, Bethany Girard, Karen Slobod, Roderick Mcphee, Rolando Pajon, Rituparna Das, Jacqueline M. Miller, Sabine Schnyder Ghamloush, Walter N. Dehority, Kidcove Study Group

Pediatrics Research and Scholarship

BACKGROUND: Vaccination of children to prevent coronavirus disease 2019 (Covid-19) is an urgent public health need. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children 6 to 11 years of age are unknown.

METHODS: Part 1 of this ongoing phase 2-3 trial was open label for dose selection; part 2 was an observer-blinded, placebo-controlled expansion evaluation of the selected dose. In part 2, we randomly assigned children (6 to 11 years of age) in a 3:1 ratio to receive two injections of mRNA-1273 (50 μg each) or placebo, administered 28 days apart. The primary objectives were evaluation of …

Science, Technology, And Intellectual Property Rights In American Foreign Policy, Patrick Mendis

Journal of Technology Law & Policy

No abstract provided.

Diabetes, Periodontitis And The Oral Microbiome, Madison West, Kaitlin Liautaud, Charles Hunter Pitts, Michael Ricupito, Joshua Cho

Excellence Day

The association between diabetes mellitus and periodontitis has been studied thoroughly. However, the role of the oral microbiome in linking these two diseases still is not clear. The objective of this literature review is to search the current studies on oral dysbiosis in the two diseases and find out whether the oral microbiome could be a possible biomarker indicating diabetes in periodontal patients.

Creator Biographies, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.

2022-05-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Fluoroquinolone Toxicity: From Mysterious Internet Illness To My New Reality - A Memoir Of My Bout With Levofloxacin, Michael Paul Lewis

Stimulus: A Medical Humanities Journal

This short story is a memoir divulging my experience in 2017 with an antibiotic known as levofloxacin and a syndrome called fluoroquinolone toxicity. With this autobiographical account, I hope to educate readers about the toxicity of fluoroquinolone antibiotics, so they can make more informed decisions regarding their health and the health of others and, ultimately, effect positive change in the medical field, either as a student, patient, or provider as far as fluoroquinolone administration, pharmacovigilance, and “floxie” patient advocacy is concerned.

Multivalent Designed Proteins Neutralize Sars-Cov-2 Variants Of Concern And Confer Protection Against Infection In Mice, Andrew C Hunt, James Brett Case, Rita E Chen, Baoling Ying, Adam L Bailey, Natasha M Kafai, Michael S Diamond, Et Al

Open Access Publications

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the broadest efficacy was achieved with a homotrimeric version of the 75-residue angiotensin-converting enzyme 2 (ACE2) mimic AHB2 (TRI2-2) designed to geometrically match the trimeric spike architecture. Consistent with the design model, in the cryo-electron microscopy structure TRI2-2 forms a tripod at the apex of the spike protein that engaged all three receptor binding domains simultaneously. …

Ammonia Tolerance Of Exophiala Dermatitidis: A Tale Of Two Fungi, Dennis J. Baumgardner, Jessica Jf Kram

Scientific Day

No abstract provided.

Implementation Of Pharmacist Antimicrobial Stewardship Intervention At Discharge Medication Reconciliation Review, Karishma Desai, Joseph Levato

Scientific Day

No abstract provided.

Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha

Michigan Tech Publications, Part 1

N95 respirator face masks serve as effective physical barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration materials, such as nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability of face masks to protect against infection can be likely improved by incorporating components that deactivate viruses on contact. We present a facile method for covalently attaching antiviral quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics that are commonly used as filtration materials in N95 respirators via ultraviolet (UV)-initiated grafting of biocidal …

The Impact Of Covid-19 Pandemic And Agricultural Knowledge Sharing For Small Scale Farmers In Katsina State, Abubakar Magaji

Library Philosophy and Practice (e-journal)

The global pandemic of Corona Virus Disease of 2019 (COVID- 19) has affected many sectors including small scale farming. This study assess the effect of Covid-19 in agriculture and identified Small Scale Farmers’ (SSF) information sharing platforms and its efficiency level used for agricultural activities during the pandemic for the sustainability of human life and economic survival. Katsina state government has taken some measures that include luck down, restriction of movement, market closures, social distancing and self-isolation in majority of local government areas to stop the spread of the virus. Three research questions were developed to guide the study. Survey …

Medical School Watercooler Newsletter - May 24, 2022, Lindsey Lyle

Watercooler Newsletter

This is the May 24, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• M3 Case Symposium set for Friday
• Herrera presents on renal disease at international conference
• USA College of Medicine offers medical and science editing and writing service
• Kestler and Tyler highlight need for better TB diagnostic tools

Covid-19 Newsletter (Vol. 120), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

May 24, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Antimicrobial Stewardship Meets Transitions Of Care: Defining Length Of Therapy For Community-Acquired Pneumonia (Cap), Christopher Whitman, Sarah E. Moore, Matthew Song, Brian C. Bohn, Ashley M. Wilde

The University of Louisville Journal of Respiratory Infections

Introduction: Hospital-based antimicrobial stewardship efforts have traditionally focused on inpatient settings. Antibiotic prescribing at discharge is often an overlooked area of focus for antimicrobial stewardship programs. Discharge prescribing optimization is necessary to combat antibiotic overuse.

Methods: This was an observational, retrospective cohort study at a four–adult community hospital system. Four hundred adult patients admitted with community-acquired pneumonia and discharged with antibiotics were included. The primary outcome was overall (inpatient and discharge) antibiotic length of therapy. The secondary outcome was percentage of patients discharged on a fluoroquinolone who had not received one in the hospital. Descriptive statistics were utilized.

Results: The …

Female Presence Does Not Increase Testosterone But Still Ameliorates Sickness Behaviours In Male Japanese Quail, Brenna M. G. Gormally, Kaelyn Bridgette, Aubrey Emmi, Delilah Schuerman, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Infections can dramatically modify animal behaviour. The extent of these changes depends on an animal's environment. It has been proposed that testosterone modulates the suppression of behavioural symptoms of sickness under certain reproductive contexts. To further understand the role played by testosterone in modulating sickness behaviours under reproductive contexts, we studied a species, the Japanese quail, in which female exposure rapidly decreases circulating testosterone in males. Males received either an immune challenge (lipopolysaccharide – LPS) or a control injection and their behaviours, mass change and testosterone levels were quantified in the presence or absence of a female. Both the presence …

A Nickase Cas9 Gene-Drive System Promotes Super-Mendelian Inheritance In Drosophila, Víctor López Del Amo, Sara Sanz Juste, Valentino M Gantz

Faculty, Staff and Student Publications

CRISPR-based gene-drives have been proposed for managing insect populations, including disease-transmitting mosquitoes, due to their ability to bias their inheritance toward super-Mendelian rates (>50%). Current technologies use a Cas9 that introduces DNA double-strand breaks into the opposing wild-type allele to replace it with a copy of the gene-drive allele via DNA homology-directed repair. However, the use of different Cas9 versions is unexplored, and alternative approaches could increase the available toolkit for gene-drive designs. Here, we report a gene-drive that relies on Cas9 nickases that generate staggered paired nicks in DNA to propagate the engineered gene-drive cassette. We show that …

A Scoping Review Of Digital Twins In The Context Of The Covid-19 Pandemic, A Khan, M Milne-Ives, E Meinert, Ge Iyawa, Rb Jones, An Josephraj

School of Engineering, Computing and Mathematics

Background: Digital Twins (DTs), virtual copies of physical entities, are a promising tool to help manage and predict outbreaks of Covid-19. By providing a detailed model of each patient, DTs can be used to determine what method of care will be most effective for that individual. The improvement in patient experience and care delivery will help to reduce demand on healthcare services and to improve hospital management. Objectives: The aim of this study is to address 2 research questions: (1) How effective are DTs in predicting and managing infectious diseases such as Covid-19? and (2) What are the prospects and …

Effect Of Bovine Lactoferrin On Seroconversion Following Polio Vaccine Administration In Children: Protocol For A Double-Blinded Randomised Controlled Trial, Atif Habib, Sidrah Nausheen, Shanila Nooruddin, Tooba Javed, Tariq Samejo, Amjad Hussain, Suneeta Namdave, Sehrish Amirali, Muhammad Umer, Lumaan Sheikh

Department of Paediatrics and Child Health

Introduction: The oral polio vaccine (OPV) has substantial results in eliminating wild poliovirus and the vaccine of choice in polio eradication. However, the mucosal immunity induced by the OPV is still uncertain. Literature has shown that bovine lactoferrin (BLF) is a safe and useful protein found in cow's milk with extraordinary antimicrobial, antiviral, antiinflammatory and immune-modulatory functions that help children's gut to fight against micro-organisms like poliovirus. However, limited data exist regarding the effect of BLF on polio vaccine immune response. The primary objective is to evaluate the effect of BLF in enhancing mucosal and humoral immunity in children following …

Cultivating Compassion In Catholic Teachings: An Invitation To Relationship With Immigrants And Refugees With Hiv/Aids, Anna Salvestrin

Undergraduate Honors Theses

In 1989 the United States Conference of Catholic Bishops released Called to Compassion and Responsibility. This document, which articulates the official Catholic Church teaching on HIV/AIDS, emphasizes personal responsibility in limiting the spread of HIV and calls for compassion toward the sick. The bishops direct their document to Catholic clergy and parishioners and offer recommendations for government policy and parish actions that affirm human dignity. This thesis argues that the document's recommendations do not adequately consider the experiences of immigrants and refugees with HIV/AIDS and neglect sufficient attention to their lived experiences. In future documents, the bishops should use the …

Tissue-Specific Variations In Transcription Factors Elucidate Complex Immune System Regulation, Hengwei Lu, Yi-Ching Tang, Assaf Gottlieb

Faculty, Staff and Student Publications

Gene expression plays a key role in health and disease. Estimating the genetic components underlying gene expression can thus help understand disease etiology. Polygenic models termed "transcriptome imputation" are used to estimate the genetic component of gene expression, but these models typically consider only the cis regions of the gene. However, these cis-based models miss large variability in expression for multiple genes. Transcription factors (TFs) that regulate gene expression are natural candidates for looking for additional sources of the missing variability. We developed a hypothesis-driven approach to identify second-tier regulation by variability in TFs. Our approach tested two models …

International Rights Affecting The Covid–19 Vaccine Race, Samantha Johnson

University of Miami Inter-American Law Review

The impact of the COVID–19 pandemic has been felt world-wide, and despite having several vaccines in the market at this point, there are still issues of accessibility for certain countries. International intellectual property law has been a breeding ground for the exploration of intellectual curiosity and creation as it provides strong protections to creators. These strong protections have allowed for the monopolization of certain goods, such as vaccines, under the concept of patents. While patents are important to incentivize pharmaceutical companies to create life–saving medicines, these protections have also become a barrier for access to medicines, especially in less–developed countries. …

Study: Expert-Led Discussions Change Student Perceptions Of Covid Vaccines, Matt Windsor

Browse All News

No abstract provided.

Commencement, Philadelphia (2022), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus D.O. Commencement program, Class of 2022. Degrees include Doctorate in Osteopathic Medicine

Covid-19 Case Complicated With Organizing Pneumonia And Pneumothorax: Correspondence, Hammad A. Bhatti, Minh Q. Ho

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Transmission Dynamics Of Covid-19 In Ghana And The Impact Of Public Health Interventions, Sylvia Ofori, Jessica S. Schwind, Kelly L. Sullivan, Benjamin J. Cowling, Gerardo Chowell, Isaac Fung

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

This study characterized COVID-19 transmission in Ghana in 2020 and 2021 by estimating the time-varying reproduction number (Rt) and exploring its association with various public health interventions at the national and regional levels. Ghana experienced four pandemic waves, with epidemic peaks in July 2020 and January, August, and December 2021. The epidemic peak was the highest nationwide in December 2021 with Rt ≥ 2. Throughout 2020 and 2021, per-capita cumulative case count by region increased with population size. Mobility data suggested a negative correlation between Rt and staying home during the first 90 days of the pandemic. The …

Policies To Protect Healthcare Providers In Public Hospitals In Egypt Amid The First Wave Covid-19 Crisis: A Case Study, Moushira Hosny Ezzelarab Sayed

Theses and Dissertations

The emergence of coronavirus disease 2019 (COVID-19) pandemic in 2020 became a main public health problem among the worlds. Universally, healthcare workers were forced to face an unprecedented challenge since the outbreak COVID-19. The World Health Organization (WHO) has been trying to reduce transmission of COVID-19 between different countries by setting regulations and standards in attempt to control the transmission of infection. The protection of healthcare workers working as frontline workers for COVID-19 is a priority. To assess the occupational workplace policies to protect healthcare workers in public university hospitals in Egypt during the first wave of COVID-19, this research …

Meningococcal Meningitis In Sub-Saharan Africa: A Review, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

The scourge of Meningococcal Meningitis in the Sub-Saharan African nations is well known. This review paper focuses on this very important topic and describes the symptoms, diagnoses, and available vaccines for the same. The review then focuses on the Meningitis Belt of Africa and elucidates on the introduction of MenAfriVac™ vaccine. The review ends with the success of this vaccine and the future of Meningococcal Meningitis in the context of overall global climate change.

'My Name Is Peaches': Black Women's Affect In The Blues Biomyth, Taylor C. Scott

LSU Doctoral Dissertations

For this project, I am interested in the study of nuanced self-representations of Black rage that appear within African American literary traditions, specifically the blues aesthetic, wherein artists narrativize a wide spectrum of intelligent and specific emotion--not just melancholy. Blues narratives in which Black people self-represent are in direct opposition to flattened narratives of certain affective modes such as anger as a useless, backwards, pathologized, and flat feeling that appear within dominant U.S. and global iconographies. What I see in the blues aesthetic is the capacity for a multichromatic approach to studying rage and Black authorship in America. By using …