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Humidity Reduces Rapid And Distant Airborne Dispersal Of Viable Viral Particles In Classroom Settings, Antun Skanata, Fabrizio Spagnolo, Molly Metz, Davida S. Smyth, John J. Dennehy

Biology Faculty Publications (Archived)

The transmission of airborne pathogens is considered to be the main route through which a number of known and emerging respiratory diseases infect their hosts. While physical distancing and mask wearing may help mitigate short-range transmission, the extent of long-range transmission in closed spaces where a pathogen remains suspended in the air remains unknown. We have developed a method to detect viable virus particles by using an aerosolized bacteriophage Phi6 in combination with its host Pseudomonas phaseolicola, which when seeded on agar plates acts as a virus detector that can be placed at a range of distances away from …

A Review On Psychosocial Distress Among General Population Of Pakistan During Covid-19 Pandemic, Anosh Arshad Chaudhary, Iqra Arooj, Amina Elahi

Journal of Bioresource Management

The COVID-19 crisis in 2019 significantly impacted human life all over the globe. Psychological health of general population has been affected by the unpredictable circumstances and impulsion of living in isolation, if suspected positive for coronavirus. During COVID-19 outbreak, escalation of various types of psychosocial distresses such as anxiety, sleep disorders and depression has been observed in the general population globally. Thus, there is an urgent need to combat these issues through well planned strategies. The focus of this review is to conduct a thorough evaluation of the available research on the effects of COVID-19 pandemic on the mental status …

The Covid-19 Pandemic Led To The Redesign Of Library Resources And Services: Turning Crisis Into An Opportunity, Dr. Rajender Kumar

Library Philosophy and Practice (e-journal)

This paper describes the opportunities to redesign library resources and services during and after the COVID-19 crisis that has affected the lives of billions of people around the world. During this crisis, Universities, colleges, and schools suspended their normal teaching and learning activities. Crisis can sometimes transform challenges into opportunities. A crisis can be turned into an opportunity if new ways of looking, thinking, and responding are embraced. A result of COVID-19's pandemic outbreaks provided an enormous opportunity to change the information-providing way. Thus, libraries can take it as an opportunity to redesign their information resources and services. By redesigning …

An Investigation Of The Novel Use Of Bacteriophages To Diagnose And Treat Johne's Disease In Cattle, Max Kevane-Campbell

ORBioM (Open Research BioSciences Meeting)

Johne’s disease is a scourge to dairy farmers all over the world. It is an infectious disease that causes chronic inflammation and lesions along the inside of the small intestine of, primarily, ruminant animals (i.e., cattle and sheep). It is an incurable disease and urgently requires new and radical intervention strategies. Apart from careful on-site farm management practices, little can be offered to farmers to reduce the risk of infection, and nothing short of livestock culling is effective once an animal becomes infected. Currently, there are no vaccines licensed in Ireland or antibiotic treatment strategies available for Johne’s disease. This …

Thomas Jefferson University Research - A Path To Digital Equity

Thomas Jefferson University Research Magazine

Inside this issue:

04 Editorial

05 Leadership Message

06 Global Jefferson

08 Bursts of Power

09 Antitrust Laws Don’t Hinder Foreign Investment Cancer Prediction Model Misses High-Risk Black Patients

10 Enveloping Buildings in Textiles Learning from Drowsy Flies

12 COVID Briefs

13 Jefferson by the Numbers

14 Inflecting the Narrative on African Studies

16 Journey of Adaptation

18 A Path Towards Digital Equity

24 JeffSolves: A New Way of Thinking

30 The Heart’s "Little Brain"

36 RNA like You’ve Never Seen Before

38 Online Content

Orally Delivered Perilla (Perilla Frutescens) Leaf Extract Effectively Inhibits Sars-Cov-2 Infection In A Syrian Hamster Model, Yuan-Fan Chin, Wen-Fan Tang, Yu-Hsiu Chang, Tein-Yao Chang, Wen-Chin Lin, Chia-Yi Lin, Chuen-Mi Yang, Hsueh-Ling Wu, Ping-Cheng Li, Jun-Ren Sun, Shu-Chen Hsu, Chia-Ying Lee, Hsuan-Ying Lu, Jia-Yu Chang, Jia-Rong Jheng, Cheng Cheung Chen, Jyh-Hwa Kau, Chih-Heng Huang, Cheng-Hsun Chiu, Yi-Jen Hung, Hui-Ping Tsai, Jim-Tong Horng

Journal of Food and Drug Analysis

On analyzing the results of cell-based assays, we have previously shown that perilla (Perilla frutescens) leaf extract (PLE), a food supplement and orally deliverable traditional Chinese medicine approved by the Taiwan Food and Drug Administration, effectively inhibits SARS-CoV-2 by directly targeting virions. PLE was also found to modulate virus-induced cytokine expression levels. In this study, we explored the anti-SARS-CoV-2 activity of PLE in a hamster model by examining viral loads and virus-induced immunopathology in lung tissues. Experimental animals were intranasally challenged with different SARS-CoV-2 doses. Jugular blood samples and lung tissue specimens were obtained in the acute disease stage (3−4 …

توصيف المجتمعات البكتيرية في لحم الضأن الفلسطيني بواسطة التنميط الظاهري و تحليل جين 16s Rrna, Wafa Masoud, Mahmoud Hamdan

Palestine Technical University Research Journal

The main purpose of the present study was to isolate, identify and quantify bacteria in Palestinian fresh lamb meat. Phenotyping and 16S rRNA gene sequence analysis was used to identify bacteria present in lamb meat samples. Thirty-four bacterial isolates were obtained from 20 samples of fresh lamb meat collected from 4 meat shops in Tulkarem city in Palestine. Bacterial counts were in a range of 3 x 103 -1.5 x 105 cfu / g with Staphylococcus aureus being the highest in numbers among other bacteria. Enterobacteriaceae and Staphylococ-caceae were the predominant bacterial families detected in fresh lamb meat samples. Two …

Turtle Island Indigenous Science Conference, 14 - 16 June 2022

Indigenous Science Network

The University of Manitoba hosted the 2022 Turtle Island Indigenous Science Conference with a focus on the Indigenous approach to understanding the five elements of the world: fire, water, earth, air, and spirit. Held 14 -1 6 June, 2022 at the Fort Garry Campus, the conference included interactive sessions with world-renowned speakers, cross-pollination of ideas, and approaches to raise the profile of Indigenous STEM science.

Covid-19 Newsletter (Vol. 123), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

A Heritage Of Bias: From Naturalization And Immigration Laws In The Late 19th To Early 20th Centuries To Contemporary Bias Against Muslims And Latines, William D. Popkin

Indiana Journal of Law and Social Equality

No abstract provided.

June 14, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Factors Associated With Covid-19 Vaccine Intentions Among South Carolina Residents, Mufaro Kanyangarara, Lauren Mcabee, Virginie G. Daguise, Melissa Nolan Ph.D., Mph

Faculty Publications

Despite evidence of vaccine safety and efficacy, vaccine hesitancy remains a major global health threat. The COVID-19 vaccine has presented unique vaccine hesitancy concerns compared to parental vaccine hesitancy towards childhood vaccines. South Carolina (SC) is home to a largely conservative population and historically has some of the lowest vaccination coverage rates in the United States of America. The goal of the current study was to identify factors associated with COVID-19 vaccine intentions among SC residents. From November 2020 to September 2021, 300,000 invitations to participate in community testing and complete an online survey were mailed to randomly selected SC …

Potential Use Of Microwave Technology In Dermatology, A. K. Gupta, M. Venkataraman, L. T. Joshi, E. A. Cooper

Peninsula Dental School

No abstract provided.

Global Health At The Local Level: Innovative Approaches For Preventing Hiv/Aids Among Adolescent Girls In Botswana With Evidence From An Evaluation Study On Perceptions Of Cross Generational Sex And Edutainment Strategies, Rebecca L. Upton

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

The Art Of Teaching Anthropology: Examples From Biological Anthropology, Susan Kirkpatrick Smith, Laura D. Lund, Marilyn R. London

Proceedings of the annual meeting of the Southern Anthropological Society

Teaching in a college or university setting has many challenges, including often-inadequate preparation in graduate school and the requirement to develop new courses, often in a short period of time. Anthropology faculty are at a particular disadvantage because anthropology lacks any discipline-specific journals for the publication of articles on the scholarship of teaching and learning. Many anthropology faculty desire to have more resources available for course and assignment development. In this chapter, we present several examples of course syllabi, class activities, and a sample student paper that faculty can use as they develop or revise anthropology courses.

The Balance Sheet Healthcare Model For African American Communities, Winifred D. Scott

Southern University College of Business E-Journal

Appalled by the over-representation of the African-American community with diseases of the heart, lungs, blood, liver, kidneys, and intestines this paper presents an innovative model, Balance Sheet Healthcare Model, using an accounting framework as a way of thinking about the body and the effects of food consumption choices, to control and lower healthcare costs and increase individual’s wellbeing.

Meta-Analysis Of 175 Patients With Covid-19 And Seizures, Status Epilepticus, Or Cortical Myoclonus: An Individual Patient Data Analysis, Aditi Kappagantu Bs, Helena A. Brantz Ms, Amman Bhasin Ba, Cristina Jageka Bs, Rooqash Ali Md, Izzy Saef Md, Brittany M. Stopa Mph, Ayaz Khawaja Md

Medical Student Research Symposium

Objective

To characterize management and outcomes of seizures, status epilepticus, and cortical myoclonus in COVID-19, with individual patient data analysis of published literature.

Methods

Systematic literature review was conducted in accordance with PRISMA guidelines. Criteria included new-onset seizures, status epilepticus, and/or cortical myoclonus with concomitant COVID-19. COVID-19 severity was dichotomized into mild and severe cases. Good outcome was defined as discharge without severe deficits, and/or return to baseline.

Results

A total of 105 studies reporting 176 patients (male 56.3%;mean age 47.8,SD 25.6) were included. Status epilepticus occurred in 47 patients (26.7%) and myoclonus in 41 (23.3%). Severe COVID-19 occurred in …

Impact Of Delayed Dermatology Consultation On Inpatient Care, Andrew S. Kao, Andrew D. King, Redina Bardhi, Meghan Mansour, Steven Daveluy

Medical Student Research Symposium

Introduction: Dermatology consultation for inpatient skin disorders enhances care by changing diagnoses, management plans, and reducing length of stay. Our goal is to quantify the time delay from primary team to dermatology consult, and its impact on hospital course as well as overall patient care.

Methods: Retrospective chart review of all inpatient dermatology consults from October 1, 2013 to December 31, 2016 at five hospitals within the Detroit Medical Center. Data included demographics, diagnosis, management plans from primary and consulting teams, and timing of initial recognition of skin problem to dermatology and other specialties consultations.

Results: 873 consultations met criteria …

False-Positive Serum Igm/Igg To Sars-Cov-2 In A Rare Pulmonary Neuroendocrine Carcinoma With Ocular Metastasis: A Case Report, Irandi P. Pratomo, Gatut Priyonugroho, Aris Ramdhani, Dian Zamroni, Thariqah Salamah, Yayi D.B Susanto, Ramdinal A. Zairinal, Annisa N. Witjaksono, Dita Aditianingsih, Jamal Zaini

The New Ropanasuri Journal of Surgery

The Coronavirus disease 2019 (COVID-19) pandemic impacts pulmonary cancer management since it shares similar clinical features and creates fear among patients to visit hospitals due to possible in-hospital disease transmission. We report a patient who presented with a rare case of a pulmonary neuroendocrine tumor with an ocular involvement, which, unfortunately, experienced a delay in diagnostics. The first hospitalization was due to superior vena cava syndrome, pleural and pericardial effusions, and swollen left eye. The patient was diagnosed with pulmonary cancer, released after the symptoms were relieved, and expected to visit a referral hospital for further diagnostics and treatments. The …

Decisional Tools For Successful Commercialisation Of Novel Vaccine Technologies, Christos Stamatis, Tania D. Pereira Chilima, Jose Castillo, Suzanne Fraid

Vaccine Technology VIII

With the emergence of personalised cancer vaccines and more recently with the COVID-19 pandemic, the increasing need for novel and disruptive manufacturing and supply chain strategies to deliver affordable vaccines has been highlighted. Decision-support tools are essential to accelerate and enhance decision-making during the development, commercialisation and distribution of prophylactic or therapeutic vaccines across the globe. This presentation will share our most recent insights from UCL’s Bioprocess Decisional Tools research on modelling the economics of integrated and intensified manufacturing technologies for viral vectors and mRNA vaccines.

On the mRNA front, UCL collaborated with Univercells Technologies and Quantoom Biosciences to explore …

Overviews Of Vaccine Technology For Neglected Diseases In Developing Latin America Country - Peru, Karen D. Calvay Sanchez, Yanina Zarate Sulca, Giovanna Mendoza Mujica

Vaccine Technology VIII

Immunization has been the greatest strategy to prevent sickness and death associated with infectious diseases [1]. So, vaccine technology has evolved to produce more immunogenic vaccines and to avoid the exposure to disease-causing organisms during manufacturing and treatment [2]. Conversely, 2.5 million people are still dying globally each year from vaccine-preventable diseases since the underuse of vaccines and lack vaccines against non-well studied pathogens [2]. Only Cuba, Brazil and Argentina are listed as producers of vaccines against infectious diseases such as yellow fever, leishmaniasis and rotavirus [3]. The roles of mentioned developing countries are crucial because the produced vaccines are …

Microbial Platform For Vaccine Production For Low-And Medium-Income Countries (Lmics): 2 Case Studies, Salomé De Sá Magalhães, Stephen A. Morris, M. Lourdes Velez-Suberbie, Acep Riza Wijayadikusumah, Neni Nurainy, Eli Keshavarz-Moore

Vaccine Technology VIII

Vaccination is critical for the prevention and control of infectious-disease outbreaks, being of paramount importance to global health, they are a key component of primary health care and an indisputable human right. Yet far too many people around the world have insufficient access to vaccines. The limited availability and affordability of vaccines to resource low-income countries has created a need for solutions that will ensure effective, affordable vaccine production technology. With potential for more pandemics, the urgency to expand vaccine range has become even more evident.

We will present a collaborative project between UCL and PT Bio Farma in which …

Development Of A Pentavalent Group B Streptococcus (Gbs) Glycoconjugate Vaccine In Africa, Matthew Williams, Ebrahim Mohamed, Patrick Tippoo, Seanette Wilson

Vaccine Technology VIII

A vaccine against Group B Streptococcus (GBS), utilized in a maternal immunization strategy to reduce the burden of GBS mortality and morbidity in infants, has potential for use all over the world, but would have the greatest impact in low-resource countries that have limited access to interventions. Currently there is no vaccine against GBS. The Biovac Institute (Biovac), a private public partnership in South Africa, is developing a pentavalent, polysaccharide-protein conjugate vaccine (PCV) against GBS — using state-of-the-art technology and targeting the most common strains.

Please click Download on the upper right corner to see the full abstract.

Please click …

Development Of The Oxford Astazeneca Covid Vaccine, Sarah Gilbert

Vaccine Technology VIII

The 2014 outbreak of Ebola virus disease in West Africa, chiefly in Guinea, Sierra Leone, and Liberia, but with cases spreading to other countries highlighted the lack of preparedness for combating infectious disease outbreaks. The virus was first identified in 1976, but vaccine development had proceeded slowly and no candidate vaccines had progressed further than phase I trials. In 2014 two new candidate vaccines entered rapid clinical development with encouraging early results, but efficacy trials were slow to start. Ebola is only one of many known viruses with the potential to cause outbreaks, and with the support of the WHO …

A Rapid Response Vaccine Manufacturing Platform As A Countermeasure To Epidemic Threats, Tania Pereira Chilima, Héla Kallel

Vaccine Technology VIII

The preparedness and rapid response to emerging infectious diseases outbreaks remains challenging due to limited market incentives. The development and manufacturing of vaccines are today facing bottlenecks in development time as well as in cost-effectiveness in order to be able to react rapidly and deliver low-cost, high-quality vaccines.

Please click Download on the upper right corner to see the full abstract.

Development Of A Pentavalent Group B Streptococcus (Gbs) Glycoconjugate Vaccine In Africa, Seanette Wilson, Ebrahim Mohamed, Patrick Tippoo, Matthew Williams

Vaccine Technology VIII

A vaccine against Group B Streptococcus (GBS), utilized in a maternal immunization strategy to reduce the burden of GBS mortality and morbidity in infants, has potential for use all over the world, but would have the greatest impact in low-resource countries that have limited access to interventions. Currently there is no vaccine against GBS. The Biovac Institute (Biovac), a private public partnership in South Africa, is developing a pentavalent, polysaccharide-protein conjugate vaccine (PCV) against GBS — using state-of-the-art technology and targeting the most common strains.

A vaccine providing more than 90 % coverage against GBS infection would need to include …

Challenges And Opportunities To Formulate And Stabilize Vaccine Candidates Targeted For Use In Lmics, David Volkin

Vaccine Technology VIII

N/A

Please click Additional File below for the presentation.

An Adenovirus-Based Vaccine Manufacturing Technology Platform For Mucosal Or Parenteral Immunization Against Poultry Diseases In Sub-Saharan Africa, Omar Farnós, Esayas Gelaye, Samia Rourou, Alya Soudani, Khaled Trabelsi, Alice Bernier, Kumar Subramaniam, Martha Yami, Amine A. Kamen

Vaccine Technology VIII

Developing novel vaccine technology platforms to respond to emergency situations such as pandemic threats or zoonotic diseases is a worldwide high priority. Public health at a global scale is frequently influenced by the risk of transmission of infectious diseases from wildlife and domestic animals. Thus, veterinary vaccination and animal health monitoring are highly relevant for the deployment of a preventative global policy in the context of “one world, one health”.

In regions such as Sub-Saharan Africa, farmers’ activities are frequently affected by the impact of diseases in poultry such as avian influenza and Newcastle disease (ND). ND is one of …

A Novel Sars-Cov-2 (T Cell) Vaccine Candidate Designed Using The Ivax Platform, Kirk Haltaufderhyde, Christine M. Boyle, Andres H. Gutierrez, Mayara Grizotte-Lake, Frances Terry, Bethany G. Mcgonnigal, Nicole Ruggiero, Leonard Moise, William D. Martin, Anne S. De Groot

Vaccine Technology VIII

EpiVax, Inc., a Rhode Island-based Biotechnology company, develops vaccines that exploit T cell immunity using the innovative iVAX vaccine antigen design platform. The premise of our strategy is the crucial role T cells play in development of protective antibody and cell-mediated immunity in natural infection. Because vaccines aim to recapitulate protective immune responses in infection, a vaccine should effectively harness T cell immunity to be protective. The significance of T cell immunity is underscored by COVID-19. Efficacy trial and real-world COVID-19 vaccine data for different vaccine modalities show a single vaccine dose is as much as 90% effective starting 14 …

Genetically Detoxified Diphtheria And Tetanus Toxins, Ecocrm197® And 8mtt, Expressed In An Engineered E. Coli Strain And Use As Conjugate Vaccine Carrier Proteins, Andrew Lees, Morgane Ollivault-Shiflett, Min-Ju Chang, Renaud Jacquemart

Vaccine Technology VIII

We have developed a novel E. coli expression system, which we call the Gor/Met strain. Gor/Met E. coli has an oxidative cytoplasm and can express disulfide-bonded proteins as intracellular, soluble, properly-folded proteins. In addition to the oxidative cytoplasm, the strain has been engineered to efficiently cleave the N-terminal methionine found on cytoplasmic E. coli proteins. To create an oxidative cytoplasm, we deleted the gor gene in BL21 E. coli, resulting in an oxidative cytoplasm. We used the gor- strain to produce the conjugate vaccine carrier protein CRM₁₉₇ in a fermenter. CRM₁₉₇ was expressed as a soluble, properly …