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Vulnerability, Invulnerability, And The Mechanism Of Disavowal, Mariah C. Partida

Philosophy ETDs

In this dissertation, I defend the view that, contrary to popular opinion, vulnerability is not merely susceptibility to harm but also openness to unanticipated change and transformation. Drawing on the work of Simone de Beauvoir, Judith Butler, Erinn Gilson, Gilles Deleuze, and Benedict Spinoza, I also aim to show that vulnerability is not a static property of some individuals but rather a relational process that is both universal and differently distributed. My original contribution to vulnerability studies is to trace the mechanism of disavowal across 20^th and 21^st century figures in philosophy: from Heidegger’s account of disavowing our …

Rapid Detection Of An Ebola Biomarker With Optical Microring Resonators, Abraham J Qavi, Krista Meserve, M Javad Aman, Hong Vu, Larry Zeitlin, John M Dye, Jeffrey W Froude, Daisy W Leung, Lan Yang, Frederick W Holtsberg, Ryan C Bailey, Gaya K Amarasinghe

2020-Current year OA Pubs

Ebola virus (EBOV) is a highly infectious pathogen, with a case mortality rate as high as 89%. Rapid therapeutic treatments and supportive measures can drastically improve patient outcome; however, the symptoms of EBOV disease (EVD) lack specificity from other endemic diseases. Given the high mortality and significant symptom overlap, there is a critical need for sensitive, rapid diagnostics for EVD. Facile diagnosis of EVD remains a challenge. Here, we describe a rapid and sensitive diagnostic for EVD through microring resonator sensors in conjunction with a unique biomarker of EBOV infection, soluble glycoprotein (sGP). Microring resonator sensors detected sGP in under …

Subsidizing The Unvaccinated: Considering The Legality And Practicality Of Vaccine Mandates For Those On Public Assistance, Michael Conklin

Journal of Legislation

No abstract provided.

The President’S Remedy–What The Hydroxychloroquine Story Teaches Us About The Need To Limit Off-Lable Prescribing Powers, Jennifer Bard

Catholic University Law Review

When the history of the first year of the United States Government’s response to the COVID-19 virus is written, there is likely to be mention of the still unexplained vehemence with which then president Donald J. Trump made use of his access to social media to promote seldom used anti-malaria drug, hydroxychloroquine, for both the prevention and treatment of COVID-19 despite the active growing opposition of most of the world’s scientists, including his own government scientists. While the use of drugs developed and approved by the FDA for different purposes to combat new diseases, off-label prescribing, is legal in the …

Robust Network Stability Of Mosquitoes And Human Pathogens Of Medical Importance, Donald A. Yee, Catherine Dean Bermond, Limarie J. Reyes-Torres, Nicole S. Fijman, Nicole A. Scavo, Joseph Nelsen, Susan H. Yee

Faculty Publications

Background: The exact number of mosquito species relevant to human health is unknown, posing challenges in understanding the scope and breadth of vector–pathogen relationships, and how resilient mosquito vector–pathogen networks are to targeted eradication of vectors.

Methods: We performed an extensive literature survey to determine the associations between mosquito species and their associated pathogens of human medical importance. For each vector–pathogen association, we then determined the strength of the associations (i.e., natural infection, lab infection, lab dissemination, lab transmission, known vector). A network analysis was used to identify relationships among all pathogens and vectors. Finally, we examined how …

Intouch June 20, 2022, New York Medical College

InTouch

• NYMC Honors Historic Partnership with NYC Health + Hospitals/Metropolitan During Plaque Dedication Ceremony
• COVID-19 Essentials
• Kristy Tefft, M.S. ’20, SOM Class of 2024, Puts a Premium on Patient Relationships
• The Department of Environmental Health and Safety Keeps the NYMC Community Safe and in Compliance
• Donate Life Clubs Finishes Exceptional Year With Record-Breaking Donations

Constructing Green Gdp Evaluation System By Using Think Tank Double Helix Methodology, Hongbing Wang, Yijun Liu, Dawei Song

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the new development stage, taking green GDP as the starting point for the development of green economy, low-carbon economy, and circular economy and an important indicator to measure high-quality development, sustainable development, and modernization is an effective way to ensure the construction of "beautiful China", basically realize socialist modernization and achieve the goal of carbon neutrality. This study uses the double helix theory of think tank to innovate a new paradigm of green GDP research and broaden the research path of GDP evaluation system. In terms of epistemology, the think tank double helix methodology provides a new systematic perspective …

Time-To-Event Modeling For Hospital Length Of Stay Prediction For Covid-19 Patients, Yuxin Wen, Md. Fashiar Rahman, Yan Zhuang, Michael Pokojovy, Honglun Xu, Peter Mccaffrey, Alexander Vo, Eric Walser, Scott Moen, Tzu-Liang Bill Tseng

Engineering Faculty Articles and Research

Providing timely patient care while maintaining optimal resource utilization is one of the central operational challenges hospitals have been facing throughout the pandemic. Hospital length of stay (LOS) is an important indicator of hospital efficiency, quality of patient care, and operational resilience. Numerous researchers have developed regression or classification models to predict LOS. However, conventional models suffer from the lack of capability to make use of typically censored clinical data. We propose to use time-to-event modeling techniques, also known as survival analysis, to predict the LOS for patients based on individualized information collected from multiple sources. The performance of six …

Pneumococcal Carriage In Infants Post-Pcv10 Introduction In Pakistan: Results From Serial Cross-Sectional Surveys, Shahira Shahid, Amala Khan, Muhammad Imran Nisar, Farah Khalid, Muhammad Farrukh Qazi, Sheraz Ahmed, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Syed Asad Ali, Anita K. M. Zaidi, Fyezah Jehan

Department of Paediatrics and Child Health

The 10-valent pneumococcal vaccine was introduced in Pakistan's Expanded Program on Immunization (EPI) in 2013 as a 3 + 0 schedule without catchup. We conducted three annual cross-sectional surveys from 2014-2016 to measure vaccine-type (VT) carriage in infants from a rural part of Pakistan. Nasopharyngeal specimens were collected by random sampling of infants from two union councils of Matiari. Samples were then transported to the Infectious Disease Research Laboratory (IDRL) at the Aga Khan University within 6-8 h of collection. Serotypes were established using sequential multiplex PCR. Of the 665 children enrolled across three surveys, 547 were culture-positive for pneumococcus. …

Aspartyl Protease Inhibitors As Anti-Filarial Drugs, Liana Beld, Hyeim Jung, Christina A Bulman, Bruce A Rosa, Peter U Fischer, James W Janetka, Sara Lustigman, Judy A Sakanari, Makedonka Mitreva

2020-Current year OA Pubs

The current treatments for lymphatic filariasis and onchocerciasis do not effectively kill the adult parasitic nematodes, allowing these chronic and debilitating diseases to persist in millions of people. Thus, the discovery of new drugs with macrofilaricidal potential to treat these filarial diseases is critical. To facilitate this need, we first investigated the effects of three aspartyl protease inhibitors (APIs) that are FDA-approved as HIV antiretroviral drugs on the adult filarial nematode,

Implications Of Covid-19 Mitigation Policies On Recreational Trail Users: Exploring Antecedents To Physical Distancing On Trails Across The Rural-Urban Continuum, Christopher J. Wynveen, Ingrid Schneider, Deonne Vanderwoude, Taylor Stein, Heather Gibson, Kim Shinew, William Hendricks, Megha Budruk

Journal of Rural Social Sciences

The COVID-19 pandemic and subsequent travel restrictions led to a worldwide increase in greenspace use. The U.S. Centers for Disease Control and Prevention encouraged policies including physical distancing and COVID-related signage. However, the extent to which these policies influenced behavior is unknown. To fill this gap, we report on a 2020 observational study at 14 trails across six U.S. states framed within a social-ecological model. Behavioral observations of 8,093 groups assessed compliance rates with infection-mitigation behaviors. Additionally, we noted the presence of COVID-related signs, the days between the observation and stay-at-home order start date, the setting (i.e., urban, suburban, and …

Preventive Behaviors Along The Rural-Urban Continuum In Utah During The Covid-19 Pandemic, Jessica D. Ulrich-Schad, Jennifer E. Givens, Mitchell Beacham

Journal of Rural Social Sciences

Rural individuals and places face major vulnerabilities in relation to the COVID-19 pandemic, yet how and why rural residents adopted preventive behaviors as a result is not well understood. Using cross-sectional data from an online panel survey of Utahans along the rural-urban continuum collected in June of 2020, we find that, overall, rural Utahans were less likely than their more urban counterparts to adopt preventive behaviors. Those who perceived less risk, knew someone sick with COVID-19, thought former President Trump was doing a good job handling the pandemic, had false optimism about the pandemic, had less formal education, and belonged …

Rural-Urban And Within-Rural Differences In Covid-19 Mortality Rates, Yue Sun, Kent Jason G. Cheng, Shannon M. Monnat

Journal of Rural Social Sciences

Since late-2020, COVID-19 mortality rates have been higher in rural than in urban America, but there has also been substantial within-rural heterogeneity. Using CDC data, we compare COVID-19 mortality rates across the rural-urban continuum as well as within rural counties across different types of labor markets and by metropolitan adjacency. As of October 1, 2021, the cumulative COVID-19 mortality rate was 247.0 per 100,000 population in rural counties compared to 200.7 in urban counties. Higher COVID-19 mortality rates in rural counties are explained by lower average educational attainment and lower median household income. Within rural counties, mortality rates have been …

Factors Explaining Variations In Covid-19 Deaths In Rural America, Don E. Albrecht

Journal of Rural Social Sciences

Early in the COVID-19 pandemic, case and death rates from the disease in rural counties were significantly lower than in urban counties. This pattern changed during the summer and fall of 2020, and by December, death rates in rural counties were higher than in urban counties. This article uses data from the U.S. Census Bureau and voting and COVID-19 data from The New York Times to explore factors related to the increase in COVID-19 deaths in rural counties in the United States. Further analysis is conducted to understand variations in death rates across different types of rural counties. Multivariate regression …

The Roleo F Selectionin Maintaining Mhc Variationi N Mammals: Heterozygotaed Vantage,R Area Llelea Dvantagea Nd Mate Choice, Carol Titterton Ms

Student Scholarship

The major histocompatibility complex (MHC) is the most polymorphic gene

region in jawed vertebrates. Its gene products play a critical role in determining

individual and population fitness by presenting foreign antigens to immune system

cells, thereby initiating immune response to pathogen and parasite infections and

cancer. I surveyed the literature to investigate how selection maintains such

important adaptive diversity in mammalian populations and how MHC diversity

affects individual and population fitness. Balancing selection in the form of either

heterozygote advantage or rare allele advantage has long been proposed as the key

mechanism for maintaining the extreme diversity in MHC gene …

Symptomatic, Clinical And Biomarker Associations For Mortality In Hospitalized Covid-19 Patients Enriched For African Americans, Hassan Ashktorab, Antonio Pizuorno, Folake Adeleye, Adeyinka Laiyemo, Maryam Mehdipour Dalivand, Farshad Aduli, Zaki A Sherif, Gholamreza Oskrochi, Kibreab Angesom, Philip Oppong-Twene, Suryanarayana Reddy Challa, Nnaemeka Okorie, Esther S Moon, Edward Romos, Boubini Jones-Wonni, Abdoul Madjid Kone, Sheldon Rankine, Camelita Thrift, Derek Scholes, Chiamaka Ekwunazu, Abigail Banson, Brianna Mitchell, Guttu Maskalo, Jillian Ross, Julencia Curtis, Rachel Kim, Chandler Gilliard, Geetha Ahuja, Joseph Mathew, Warren Gavin, Areeba Kara, Manuel Hache-Marliere, Leonidas Palaiodimos, Vishnu R. Mani, Aleksandr Kalabin, Vijay Reddy Gayam, Pavani Reddy Garlapati, Joseph B. Miller Md, Lakshmi Gayathri Chirumamilla, Fatimah Jackson, John M. Carethers, Farin Kamangar, Hassan Brim

Emergency Medicine Articles

BACKGROUND AND AIMS: Initial reports on US COVID-19 showed different outcomes in different races. In this study we use a diverse large cohort of hospitalized COVID-19 patients to determine predictors of mortality.

METHODS: We analyzed data from hospitalized COVID-19 patients (n = 5852) between March 2020- August 2020 from 8 hospitals across the US. Demographics, comorbidities, symptoms and laboratory data were collected.

RESULTS: The cohort contained 3,662 (61.7%) African Americans (AA), 286 (5%) American Latinx (LAT), 1,407 (23.9%), European Americans (EA), and 93 (1.5%) American Asians (AS). Survivors and non-survivors mean ages in years were 58 and 68 for AA, …

Sars-Cov-2 Neuroinvasion, Inflammatory Neurodegeneration And Alzheimer's Disease, Yuhai Zhao, Walter J. Lukiw

School of Medicine Faculty Publications

No abstract provided.

Fusobacterium Necrophorum Septicemia Secondary To An Ovarian Abscess: A Case Report., Amanda Morrall, Uwe Schmidt

Ambulatory and Primary Care Articles

Fusobacterium necrophorum is part of the normal oropharyngeal flora and can result in a life-threatening systemic infection known as Lemierre's syndrome. A rare presentation of F. necrophorum infection is seen in the female genital tract and is typically due to obstetric infections. Here we present a unique case of F. necrophorum without traditional features of Lemierre's syndrome with the female genital tract as a primary site. A 50-year-old female presents with a two-month history of nausea, vomiting, abdominal pain, and weight loss. She ultimately developed bilateral lower extremity necrotizing fasciitis, colonic perforation, and a left chest wall abscess. Blood and …

Deprivation Of Liberty Relating To Detention In Irish Residential Care Centres For The Older Person; A Legal And Ethical Analysis, Florence Horsman Hogan

Theses

People enter residential care for a wide variety of reasons, with many people stating they would prefer to live in their own homes. Lack of community resources may lead to an older person entering residential care against their stated will and preferences. Recent case law in Ireland has established that outside of the Mental Health Act (2001) and for infection control purposes the 1947 Health Act, there is no legal provision in Irish healthcare which allows for a person to be detained against their will. The Assisted Decision Making (Capacity) Act 2015 is a key piece of legislation to enable …

Anxiety Of Struggling Readers And Excelling Readers During The Covid-19 Pandemic, Chelsey Taylor Lemmon

Theses and Dissertations

Anxiety is the most reported negative emotion in the academic setting. One of the specific forms of anxiety that children can experience is reading anxiety (RA). Children who experience RA are often at risk for reading failure; likewise, children who experience reading failure are likely to experience RA. Children who excel at reading can also experience anxiety, often in the form of harm avoidance. Bibliotherapy has been shown to help to mitigate the effects of specific types of anxiety in children. The purpose of this study was to understand the anxiety of children who excel at reading and children at …

How Different Pre-Existing Mental Disorders And Their Co-Occurrence Affects Covid-19 Clinical Outcomes? A Real-World Data Study In The Southern United States, Shan Qiao Ph.D., Jiajia Zhang Ph.D., Shujie Chen, Bankole Olatosi Ph.D., Suzanne Hardeman, Meera Narasimhan, Larisa Bruner, Abdoulaye Diedhiou, Cheryl Scott, Ali Mansaray, Sharon Weissman, Xiaoming Li Ph.D.

Faculty Publications

Background: Although a psychiatric history might be an independent risk factor for COVID-19 infection and mortality, no studies have systematically investigated how different clusters of pre-existing mental disorders may affect COVID-19 clinical outcomes or showed how the coexistence of mental disorder clusters is related to COVID-19 clinical outcomes.

Methods: Using a retrospective cohort study design, a total of 476,775 adult patients with lab-confirmed and probable COVID-19 between March 06, 2020 and April 14, 2021 in South Carolina, United States were included in the current study. The electronic health record data of COVID-19 patients were linked to all payer-based claims data …

A Comparison Of Univariate And Multivariate Forecasting Models Predicting Emergency Department Patient Arrivals During The Covid-19 Pandemic, Egbe-Etu Etu, Leslie Monplaisir, Sara Masoud, Suzan Arslanturk, Joshua Emakhu, Imokhai Tenebe, Joseph B. Miller Md, Thomas K. Hagerman, Daniel N. Jourdan, Seth Krupp

Emergency Medicine Articles

The COVID-19 pandemic has heightened the existing concern about the uncertainty surrounding patient arrival and the overutilization of resources in emergency departments (EDs). The prediction of variations in patient arrivals is vital for managing limited healthcare resources and facilitating data-driven resource planning. The objective of this study was to forecast ED patient arrivals during a pandemic over different time horizons. A secondary objective was to compare the performance of different forecasting models in predicting ED patient arrivals. We included all ED patient encounters at an urban teaching hospital between January 2019 and December 2020. We divided the data into training …

Investigating A Potential Sting Modulator, Jaret J. Crews

USF Tampa Graduate Theses and Dissertations

The work contained in this thesis introduces a protein known as STING, an acronym for STimulator of INnterferon Genes, an immunosurveillance ER-membrane bound adapter protein critical to regulating the innate immune response in humans. The first chapter provides an overview of the STING pathway, outlines STING’s potential as a therapeutic target of interest, and delineates the primary challenges researchers encounter when designing small molecules to modulate the activity of STING. Current efforts in developing STING modulators have focused on devising agonists to up-regulate the STING pathway as a possible therapeutic for human cancers based on the chemical scaffold of STING’s …

Congenital Co-Infections Among Hiv-Exposed Infants Born To Mothers On Antiretroviral Treatment In The United States., Christiana Smith, Lori Silveira, Megan Crotteau, Krystle Garth, Jennifer Canniff, Kirk B. Fetters, Sarah Lazarus, Shannon Capraro, Adriana Weinberg, Chip Perinatal Team

Manuscripts, Articles, Book Chapters and Other Papers

Background: Many women living with HIV (WLHIV) are co-infected with cytomegalovirus (CMV), Toxoplasma gondii (T gondii), and/or hepatitis C virus (HCV). The rates of congenital or perinatal transmission of these co-infections are not well defined in the current era, when most WLHIV receive antiretroviral therapy (ART) during pregnancy.

Methods: Retrospective review of infants of WLHIV born between 2009-2019. Mothers were screened for antibodies to CMV, T. gondii, and HCV; chronic HCV infection was confirmed using plasma RNA PCR. Infants whose mothers had positive/unknown serostatus were screened for CMV using urine or saliva DNA PCR or culture at ≤3 …

June 15, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

2022-06-15_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Deciphering Taxa-Function Relationships In Population-Level Studies Of Human Gut Microbiomes, Quang P. Nguyen

Dartmouth College Ph.D Dissertations

The human gut microbiome is a complex and dynamic ecosystem, featuring a multitude of microbes all interacting with their hosts in an elaborate manner. Even though this exchange is often mediated through microbial metabolic and functional outputs, such as the production of certain metabolites, environmental exposures, and host lifestyle are highly influential in shaping the presence of microbial species irrespective of their individual roles. As such, a comprehensive understanding of the microbiome requires researchers to examine the relationship between taxonomic abundance and function simultaneously. Assessing microbial contributions to important ecosystem services can enable identification of robust functions supported by a …

How Different Pre-Existing Mental Disorders And Their Co-Occurrence Affects Covid-19 Clinical Outcomes? A Real-World Data Study In The Southern United States, Shan Qiao Ph.D., Jiajia Zhang Ph.D., Shujie Chen, Bankole Olatosi Ph.D., Suzanne Hardeman, Meera Narasimhan, Larisa Bruner, Abdoulaye Diedhiuo, Cheryl Scott, Ali Mansaray, Sharon Weissman, Xiaoming Li Ph.D.

Faculty Publications

Background: Although a psychiatric history might be an independent risk factor for COVID-19 infection and mortality, no studies have systematically investigated how different clusters of pre-existing mental disorders may affect COVID-19 clinical outcomes or showed how the coexistence of mental disorder clusters is related to COVID-19 clinical outcomes. Methods: Using a retrospective cohort study design, a total of 476,775 adult patients with lab-confirmed and probable COVID-19 between March 06, 2020 and April 14, 2021 in South Carolina, United States were included in the current study. The electronic health record data of COVID-19 patients were linked to all payer-based claims data …

Implementation Of A Central Line Maintenance Checklist In The Medical Intensive Care Unit, Charles Reynolds

Group: Samford University Moffett & Sanders School of Nursing

Central line-associated bloodstream infections (CLABSIs) are key participants in hospital acquired infections (HAIs) that place heavy financial and medical burden on healthcare practices and facilities. Hospitals formulate central line bundles and checklists based off policies and procedures the NHSN provided about indications for central lines, procedures for insertion and maintenance of those central lines, and prevention measures. Critical care units experienced the greatest increase of CLABSIs from a national rate of 0.75 in 2019 to 1.04 in 2020 (Patel et al., 2021). Research shows that these measures and procedures work when intensive care unit nurses are compliant with theses interventions …

What Covid-19 Laid Bare: Adventures In Workers’ Compensation Causation, Michael C. Duff

San Diego Law Review

This Article performs a close analysis of workers’ compensation coverage of COVID-19 and arrives at the conclusion that it should not be “impossible” to prove in a legal sense that an employee’s COVID-19 was caused by work. Scientific proof is not the same as legal proof: Workers’ compensation law has never required that claims must be supported by irrefutable scientific proof of workplace causation. Yet repeatedly one heard this suggestion during public discussion on workers’ compensation coverage of employees.

Still, there is good evidence that even when workers’ compensation undisputedly covers work-related disease, employers seldom pay benefits and states do …