Digital Commons Network^™

Conventional And Advanced Mr Imaging Findings In A Cohort Of Pathology-Proven Dermoid Cysts Of The Pediatric Scalp And Skull, Bettina L Serrallach, Gunes Orman, M John Hicks, Nilesh Desai, Stephen Kralik, Thierry Agm Huisman

Faculty, Staff and Students Publications

BACKGROUND: In the pediatric population, dermoid cysts are among the most frequent lesions of the scalp and skull. Imaging plays a key role in characterizing scalp and skull lesions in order to narrow the differential diagnoses. In general, dermoids are described as heterogeneous T1-/T2-hypo- to hyperintense lesions on magnetic resonance imaging.

METHODS: The goal of this retrospective study is to evaluate the diffusion weighted imaging findings while reviewing the conventional T1-/T2-/T1+C-weighted MR characteristics in a pathology-proven series of 14 dermoids of the pediatric scalp and skull.

RESULTS: In our pediatric cohort (eight boys, six girls, age range 3-95 months), half …

Acquired Hemophilia A: A Possibly Fatal Complication Of Sars-Cov-2 Infection, Hasan Fareed Siddiqui, Taymmia Ejaz, Aisha Fareed Siddiqui, Fahd Niaz Shaikh

Department of Medicine

No abstract provided.

Fetal Loss In Pregnant Rhesus Macaques Infected With High-Dose African-Lineage Zika Virus, Lauren E. Raasch, Kevin K. Noguchi, Nicole A. Fuhler, Et Al

2020-Current year OA Pubs

Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models are important for understanding how ZIKV infections impact human pregnancy due to similarities in placental development. The lack of consistent adverse pregnancy outcomes in ZIKV-affected pregnancies poses a challenge in macaque studies where group sizes are often small (4-8 animals). Studies in small animal models suggest that African-lineage Zika viruses can cause more frequent and severe fetal outcomes. No adverse outcomes were observed in macaques exposed to 1x104 PFU (low dose) of African-lineage ZIKV at gestational day (GD) 45. Here, we exposed eight pregnant …

Mass Drug Administration Of Ivermectin, Diethylcarbamazine, Plus Albendazole Compared With Diethylcarbamazine Plus Albendazole For Reduction Of Lymphatic Filariasis Endemicity In Papua New Guinea: A Cluster-Randomised Trial, Moses Laman, Gary J Weil, Et Al.

2020-Current year OA Pubs

BACKGROUND: A single co-administered dose of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) has been shown to be safe and more efficacious for clearing Wuchereria bancrofti microfilariae than the standard two-drug regimen of diethylcarbamazine plus albendazole in clinical trials. However, the effectiveness of mass drug administration with the triple-drug regimen compared with the two-drug regimen is unknown. We compared the effectiveness of mass drug administration with the triple-drug and two-drug regimens for reducing microfilariae prevalence to less than 1% and circulating filarial antigen prevalence to less than 2%, levels that are unlikely to sustain transmission of lymphatic filariasis, in Papua …

Social Contributors For The Rise Of Covid-19 Infections In South Asia: A Large Cross-Sectional Survey, Zouina Sarfraz, Azza Sarfraz, Muzna Sarfraz, Nishwa Azeem, Namrata Hange, Miguel Felix, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Background: The ongoing global coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in South Asia on 30th January 2020 in India. Ever since, certain countries have witnessed multiple waves of COVID-19, requiring attention by public health experts and strategists in the region. The objectives of this study are to assess social contributors to the recurrent waves of COVID-19 in South Asia including first demographic traits, second household characteristics and social measures, third workplace trends and personal protective equipment use, and fourth satisfaction and attitudes concerning public health measures and vaccination status. …

Narrative Synthesis Systematic Review Of Pakistani Women's Health Outcomes From Primary Care Interventions, Sara Rizvi Jafree, Qaisar Khalid Mahmood, Sohail Mujahid, Muhammad Asim, Jane Barlow

Community Health Sciences

Objective: Women living in Pakistan have complex health problems including infectious and non-communicable diseases, accident and injuries, and mental health problems. While a majority of these women rely on primary healthcare services for all of their healthcare needs, there has to date been no overview of the extent of their effectiveness. The objective of this review was to (1) synthesise the available evidence regarding the effectiveness of primary care based interventions aimed at improving women's mental and physical health and (2) identify the factors that promote effectiveness for women's health outcomes.
Methods: Five academic databases were searched, including PubMed, BMC …

Salivary Biomarker Evaluation Of Chronic Pancreatitis Patients Reveals Alterations In Human Proteins, Cytokines, Prostaglandin E2 Levels, And Bacterial Diversity, Richard T Waldron, Elaina K Jones, Vincent I Anani, Jolaine M Hines, Jing Zhao, Aurelia Lugea, Marcio A Diniz, Sungjin Kim, Aida Habtezion, Kristi L Hoffman, Joseph F Petrosino, William E Fisher, Liang Li, Ryan J Lennon, Ravinder Jit Singh, Santhi Swaroop Vege, Stephen J Pandol, Mark D Topazian

Faculty, Staff and Students Publications

OBJECTIVES: Chronic pancreatitis (CP) is a chronic fibroinflammatory condition of the pancreas difficult to diagnose in early stages. Novel biomarkers useful to facilitate early diagnosis or treatment responses may be found in biofluids. Although saliva can be easily and noninvasively collected from patients, useful salivary biomarkers from CP patients have not yet been identified.

METHODS: Here, we analyzed the proteome by quantitative proteomics, cytokine/chemokine levels by Luminex analysis, prostaglandin E2 (PGE2) levels by a mass spectrometry-based assay, and bacterial species diversity by 16S ribosomal ribonucleic acid sequencing in saliva samples from confirmed CP patients and healthy controls.

RESULTS: Our results …

The Prevalence Of Multiple Drug Resistant Urinary Tract Infections: A Single-Centered, Observational Retrospective Study In King Abdulaziz Specialized Hospital, Taif, Saudi Arabia, Faisal K. Alhomayani, Naif M. Alazwari, Mohammed S. Alshhrani, Ali S. Alkhudaydi, Abdullah S. Basaba, Tariq M. Alharthi, Muhanad M. Alghamdi, Abdulaziz S. Aljuaid, Nasser M. Alosimi, Abdulmajeed M. Alqethami

Saudi Medical Journal

Objectives: To determine the prevalence and patterns of antibiotic resistance, risk factors, and appropriate empiric therapy for multidrug-resistant Enterococcus (MDRE) urinary tract infections (UTIs) at King Abdulaziz Specialist Hospital (KAASH), Taif, Saudi Arabia. Methods: All patients attending KAASH with MDRE UTIs between January 2018 and December 2020 were enrolled in the study. After ethical approval, data were analyzed. Results: The most common causative organisms were Gram-negative and anaerobes, and the most sensitive antibiotics were ciprofloxacin and ceftriaxone. Conclusion: Based on our analyses, regular culture and sensitivity should be made routine to gather information regarding susceptibility patterns, thereby reducing drug resistance …

False-Positive Xpert® Xpress Sars-Cov-2 Assay In An Emergency Room And Trauma Center: A Retrospective Chart Review Study, Hyerim Kim, Soeun Jeon, Sun Hack Lee, Hyun-Su Ri, Hyeon-Jeong Lee, Jeong-Min Hong, Sung In Paek

Saudi Medical Journal

Objectives: To review reports false-positive Xpert results in an emergency room and trauma center. Methods: Patients’ data with false-positive Xpert results from November 2020 to February 2022 at Pusan National University Hospital, Busan, Republic of Korea, were extracted from the electronic medical records. Results: The positive predictive value of Xpert was 40%. Of the 12 patients with false-positive results, 5 (41.7%) were re-positives (such as, patients recovered from coronavirus disease-19 [COVID-19]), and 4 (33.3%) had head or facial trauma. Two out of 4 head or facial trauma cases had documented sample contamination with blood. Conclusion: We found a high incidence …

Spiritual Health Predicts Improved Phq-9 During Covid Isolation In Extended Care Facility Patients, Thomas Huth, Cindy Schmidt, Donald G. Smith Jr., Wen Dan Lin, Alan Wang

Faculty and Staff Publications

No abstract provided.

Quantifying Inequities In Covid-19 Vaccine Distribution Over Time By Social Vulnerability, Race And Ethnicity, And Location: A Population-Level Analysis In St. Louis And Kansas City, Missouri, Aaloke Mody, Cory Bradley, Salil Redkar, Branson Fox, Ingrid Eshun-Wilson, Matifadza G. Hlatshwayo, Anne Trolard, Khai Hoan Tram, Lindsey M. Filiatreau, Franda Thomas, Matt Haslam, George Turabelidze, Vetta Sanders-Thompson, William G. Powderly, Elvin H. Geng

2020-Current year OA Pubs

BACKGROUND: Equity in vaccination coverage is a cornerstone for a successful public health response to COVID-19. To deepen understanding of the extent to which vaccination coverage compares with initial strategies for equitable vaccination, we explore primary vaccine series and booster rollout over time and by race/ethnicity, social vulnerability, and geography.

METHODS AND FINDINGS: We analyzed data from the Missouri Department of Health and Senior Services on all COVID-19 vaccinations administered across 7 counties in the St. Louis region and 4 counties in the Kansas City region. We compared rates of receiving the primary COVID-19 vaccine series and boosters relative to …

Patient Preferences For Strategies To Improve Tuberculosis Diagnostic Services In Zambia, Andrew D Kerkhoff, Lophina Chilukutu, Sarah Nyangu, Mary Kagujje, Kondwelani Mateyo, Nsala Sanjase, Ingrid Eshun-Wilson, Elvin H Geng, Diane V Havlir, Monde Muyoyeta

2020-Current year OA Pubs

Importance: Delayed engagement in tuberculosis (TB) services is associated with ongoing transmission and poor clinical outcomes.

Objective: To assess whether patients with TB have differential preferences for strategies to improve the public health reach of TB diagnostic services.

Design, Setting, and Participants: A cross-sectional study was undertaken in which a discrete choice experiment (DCE) was administered between September 18, 2019, and January 17, 2020, to 401 adults (>18 years of age) with microbiologically confirmed TB in Lusaka, Zambia. The DCE had 7 attributes with 2 to 3 levels per attribute related to TB service enhancements. Latent class analysis was …

Ankle2-Related Microcephaly: A Variable Microcephaly Syndrome Resembling Zika Infection, Ajay X Thomas, Nichole Link, Laurie A Robak, Gail Demmler-Harrison, Emily C Pao, Audrey E Squire, Savannah Michels, Julie S Cohen, Anne Comi, Paolo Prontera, Alberto Verrotti Di Pianella, Giuseppe Di Cara, Livia Garavelli, Stefano Giuseppe Caraffi, Carlo Fusco, Roberta Zuntini, Kendall C Parks, Elliott H Sherr, Mais O Hashem, Sateesh Maddirevula, Fowzan S Alkuraya, Isphana A F Contractar, Jennifer E Neil, Christopher A Walsh, Hugo J Bellen, Hsiao-Tuan Chao, Robin D Clark, Ghayda M Mirzaa

Duncan NRI Faculty and Staff Publications

Objective: This study delineates the clinical and molecular spectrum of ANKLE2-related microcephaly (MIC), as well as highlights shared pathological mechanisms between ANKLE2 and the Zika virus.

Methods: We identified 12 individuals with MIC and variants in ANKLE2 with a broad range of features. Probands underwent thorough phenotypic evaluations, developmental assessments, and anthropometric measurements. Brain imaging studies were systematically reviewed for developmental abnormalities. We functionally interrogated a subset of identified ANKLE2 variants in Drosophila melanogaster.

Results: All individuals had MIC (z-score ≤ -3), including nine with congenital MIC. We identified a broad range of brain abnormalities including simplified cortical gyral pattern, …

Glutathione Peroxidase 2 Is A Metabolic Driver Of The Tumor Immune Microenvironment And Immune Checkpoint Inhibitor Response, Kazi Mokim Ahmed, Ratna Veeramachaneni, Defeng Deng, Nagireddy Putluri, Vasanta Putluri, Maria F Cardenas, David A Wheeler, William K Decker, Andy I Frederick, Sawad Kazi, Andrew G Sikora, Vlad C Sandulache, Mitchell J Frederick

Faculty, Staff and Students Publications

BACKGROUND: The existence of immunologically 'cold tumors' frequently found across a wide spectrum of tumor types represents a significant challenge for cancer immunotherapy. Cold tumors have poor baseline pan-leukocyte infiltration, including a low prevalence of cytotoxic lymphocytes, and not surprisingly respond unfavorably to immune checkpoint (IC) inhibitors. We hypothesized that cold tumors harbor a mechanism of immune escape upstream and independent of ICs that may be driven by tumor biology rather than differences in mutational neoantigen burden.

METHODS: Using a bioinformatic approach to analyze TCGA (The Cancer Genome Atlas) RNA sequencing data we identified genes upregulated in cold versus hot …

Control Of Scabies In A Boarding School Using 5% Permethrin Applied On Lesion Only, Saleha Sungkar, Sri Wahdini, Aria Kekalih, Risa Rilanda, Hansen Angkasa, Sandra Widaty

ASEAN Journal of Community Engagement

Scabies is one of the most neglected tropical skin diseases in Indonesia. It is usually found in overcrowded communities with poor hygiene. The gold standard for scabies treatment is the whole-body topical application of 5% permethrin cream. However, the treatment causes inconvenience and stickiness for a prolonged period. The modification of topical treatment by applying only to the lesion yielded results similar with whole-body topical application. We consider using this mode of treatment to control the disease in a boarding school. The study was conducted from June to August 2019. All students were examined by dermatologists, and individuals who were …

Indonesian Capital Market Reaction To Jakarta’S Large Scale Social Restrictions, Nur Wahyu Catur Wicaksono, Y. Anni Aryani, Doddy Setiawan

The Indonesian Capital Market Review

This study aims to analyze the Indonesian capital market reaction to the Large-Scale Social Restrictions (PSBB) policy in Jakarta in 2020. The findings from this study can be used as a policy evaluation and as a reference to assess similar future policies to be implemented in Jakarta. Four event periods were used based on the number of times this policy was implemented in 2020. Using the event study approach and single index model method, this study used 568 companies listed on the IDX which are then divided into nine sectors. The results of this study showed that the Indonesian capital …

Patents And The Pandemic: Intellectual Property, Social Contracts, And Access To Vaccines, Peter Lee

Washington Journal of Law, Technology & Arts

Through enormous public support and private initiative, biopharmaceutical firms developed safe and effective COVID-19 vaccines in record time. These remarkable vaccines represent humanity’s best chance to end the devastating pandemic. However, difficult questions about ownership and access have arisen alongside the development and deployment of these vaccines. Biopharmaceutical companies have patented many of the technologies underlying these vaccines, thus seeming to pit intellectual property rights against the objective of wide and rapid dissemination of these critical resources. While prevailing debates have been framed in the language of intellectual property, this Article suggests that contract principles can help break the impasse …

Covid-19 In Indonesia: Is There A Shift From Pandemic To Endemic?, Laily Hanifah, Kemal N. Siregar

Kesmas

The world is still facing the Coronavirus Disease 2019 (COVID-19) pandemic, and the current challenge is the epidemic, which was thought to have become endemic, but it seems far from that. This article describe the recent progress of the COVID-19 globally, including in Indonesia, and what should be done towards building community health resilience. Each day, more than 500,000 new cases are being detected worldwide. This condition shows that the present pandemic is not over and still requires global vigilance. The challenge faced by the world, and Indonesia, is to develop resilient communities as a prerequisite to controlling any future …

Measuring The Success Of Pedulilindungi Application Use For Supporting Covid-19 Prevention: A Case Study Among College Students In Jakarta, Indonesia, Mochamad Iqbal Nurmansyah, Catur Rosidati, Yustiani Yustiani, Narila Mutia Nasir

Kesmas

The Indonesian Government has launched PeduliLindungi (PL) mobile apps as a COVID-19 preventive tool. This study aimed to describe the PL utilization and determine the factors influencing its successful use among college students. This study used a cross-sectional design and a total population sampling at a university in the Special Capital Region of Jakarta, Indonesia. The Delone and Mclean Information System Success Model was adopted to measure the use of the apps. The Spearman’s rank correlation test was performed to determine the relationship between two variables. Furthermore, 354 respondents participated in this study. The respondents used the apps mostly to …

Does It Still Show A Deficit? Arguing Post-Covid-19 Health Financing System In Bogor, Indonesia, Meita Veruswati, Al Asyary, Rony Darmawansyah Alnur, La Ode Hasnuddin S Sagala, Guspianto Guspianto, Maria Holy Herawati

Kesmas

Before the COVID-19 pandemic, the Bogor City Government regulated to cover the health financing claim during the Indonesian National Health Insurance (NHI) integration period due to the lower amount of health care claim per episode in regional hospitals compared to ones that NHI paid. This study aimed to address post-COVID-19 health financing at two hospitals in Bogor City, West Java Province, Indonesia. Descriptive analysis using the aggregate statistical summaries was taken to explore the medical care episodes of the data series at two hospitals for the last two years. Of the 890 checked medical records data, the deficit occurred in …

Covid-19 Prevention And Control: Mining Industry Responses To The Pandemic, Arif Susanto, Agra Mohamad Khaliwa, Muhamad Razif Iqbal, Edi Karyono Putro, Asep Dian Abdilah

Kesmas

The rapidly growing global Coronavirus Disease 2019 (COVID-19) pandemic crisis affects the labor-intensive mining industry. The industry is characterized by high worker mobility and 24-hour operations; thus, this continuous, mobile workforce increases the transmission risk of COVID-19 and has been a challenge for the mining industry during the pandemic. PT X, one of the largest mineral mining locations in Mimika District, Central Papua Province, Indonesia, was challenged to face the COVID-19 pandemic crisis. Therefore, this qualitative study aimed to analyze the COVID-19 handling efforts by PT X Concentrating Division using a descriptive-analytical method to describe the completion of PT X. …

Susceptibility Antibiotics Of Bacteria Causing Urinary Tract Infection In Pregnant Women Infected With Covid-19, Rashid Rahim Hateet

Kesmas

Urinary tract infections (UTIs) are a significant issue in women of all ages, but they are especially common during pregnancy. Co-infection of the Coronavirus Disease 2019 (COVID-19) with UTIs in pregnant females is a hot topic today, as it may be linked to various conditions. Furthermore, understanding the types of bacteria that cause UTIs and related antimicrobial resistance may aid the clinician in selecting the appropriate empirical treatment. This study aimed to isolate and characterize causative agents of UTIs and determine antimicrobial treatment sensitivity patterns among pregnant women diagnosed with the COVID-19 admitted to Teaching Hospital X in Iraq. Antimicrobial …

Role Of Community Leaders In Managing Covid-19 Pandemic In Indonesia, Nur Alvira Pascawati, Tri Baskoro Tunggul Satoto, Annisa Rizqa Alamri

ASEAN Journal of Community Engagement

Community leaders must understand their role in controlling COVID-19, such as monitoring misleading information and providing socialization, education, protection, monitoring, and evaluation activities in the community, due to the numerous limitations of local governments in managing large populations during this crisis. This study aimed to describe the role of Yogyakarta community leaders in increasing community engagement in managing the Covid-19 pandemic. This study uses a quantitative method with a cross-sectional approach, and the study sample includes all community leaders as many as 31 people at the levels of neighborhood and hamlet. The data analysis process uses frequency distribution values. Results …

Comprehensive Efforts To Accelerate Non-Communicable Disease Services In The Era Of Covid-19 In Indonesia’S Suburban Area, Akmal Taher, Soehartati A. Gondhowiardjo, Adang Bachtiar, Sabarinah Prasetyo, Irene Pixelyne, Ficky Huang, Rima Sumayyah Ahmad

ASEAN Journal of Community Engagement

The COVID-19 crisis has disrupted non-communicable disease (NCD) services in primary health care, and NCD is one of the comorbidities that increase mortality in COVID-19 patients. Efforts to accelerate NCD services were carried out with the focus on two programs: the development of integrated polyclinic NCD services and the training of community health workers (CHW) at the Tanara Community Health Center (CHC) in Banten. The development of a continuous team-based service system from the Pos Pembinaan Terpadu (Posbindu)/integrated service post to NCD services at the CHC was carried out for six months to improve the quality of human resources and …

Initiating Entrepreneurship To Improve Health Amongst People In Lio Village During The Covid-19 Pandemic: A Qualitative Study, Stella K. Triastari, Angelina Patricia Chandra, Andito M. Wibisono, Dewi Friska

ASEAN Journal of Community Engagement

Community development in Lio Village performed by Faculty of Medicine Universitas Indonesia students aimed to improve the health status of villagers. Because economy correlates with health, an economic intervention may increase the health status of the people. Based on this, an entrepreneurship program was initiated as a part of a community development program. This study is qualitative study that was conducted between July 2020 and February 2021. The intervention consisted of asynchronous webinar sessions, workshops, and business competition. Data were gathered from post-test questionnaires through a Google form. The winners were chosen according to the business ideas and given …

Data-Driven Equations For Coevolving Network Systems, Nicholas John

Theses

The framework of coevolving networks is a tool to model large-scale interacting dynamical systems undergoing change in connective structure, describing phenomena such as epidemic spreading on social networks with individuals changing their connections to avoid infection. Along with direct computational simulation, coevolving network systems are often formulated in terms of systems of ordinary differential equations in their descriptive statistics. The equation approach reduces the computational burden of analyzing the systems, but deriving equations becomes difficult as the underlying model becomes more complicated and as the desire for accuracy increases. We present an approach to construct equations for coevolving network systems …

Perception Of Covid-19 And Reproductive Health Of Female And Male Adolescents In Urban Areas In The Sustainable Development Goals, Terry Y. R. Pristya, Chahya Kharin Herbawani, Ulya Qoulan Karima, Arnur Oktafiyanti, Nadia Ramadhanty, Asto Ginawang

Journal of Environmental Science and Sustainable Development

Sustainable Development Goals (SDGs) in goal 3 (good health and well-being) and goal 4 (equality in education) for all specifically targeted at vulnerable groups. Adolescents were a part of it. A decade of progress in reproductive health could be stalled by covid-19. The study aimed to analyze reproductive health and adolescents’ perceptions during the covid-19 pandemic era in urban areas. This descriptive study used an online survey conducted in Jakarta. The sample consisted of 438 adolescents selected by convenience sampling technique. The results were that both female and male adolescents had poor knowledge about HIV/AIDS transmission (female = 77.0%; male …

Confirming Multiplex Rt-Qpcr Use In Covid-19 With Next-Generation Sequencing: Strategies For Epidemiological Advantage, Rob E. Carpenter, Vaibhav Tamrakar, Harendra Chahar, Tyler Vine, Rahul Sharma

Human Resource Development Faculty Publications and Presentations

Rapid identification and tracking of emerging SARS-CoV-2 variants are critical for understanding the transmission dynamics and developing strategies for interrupting the transmission chain. Next-Generation Sequencing (NGS) is an exceptional tool for whole-genome analysis and deciphering new mutations. The technique has been instrumental in identifying the variants of concern (VOC) and tracking this pandemic. However, NGS is complex and expensive for large-scale adoption, and epidemiological monitoring with NGS alone could be unattainable in limited-resource settings. In this study, we explored the application of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) based detection of the variant identified by NGS. We analyzed a total …

Genomic And Functional Characterization Of Vancomycin-Resistant Enterococci-Specific Bacteriophages In The Galleria Mellonella Wax Moth Larvae Model, Lynn El Haddad, Georgios Angelidakis, Justin R Clark, Jesus F Mendoza, Austen L Terwilliger, Christopher P Chaftari, Mark Duna, Serena T Yusuf, Cynthia P Harb, Mark Stibich, Anthony Maresso, Roy F Chemaly

Faculty, Staff and Students Publications

Phages are naturally occurring viruses that selectively kill bacterial species without disturbing the individual’s normal flora, averting the collateral damage of antimicrobial usage. The safety and the effectiveness of phages have been mainly confirmed in the food industry as well as in animal models. In this study, we report on the successful isolation of phages specific to Vancomycin-resistant Enterococci, including Enterococcus faecium (VREfm) and Enterococcus faecalis from sewage samples, and demonstrate their efficacy and safety for VREfm infection in the greater wax moth Galleria mellonella model. No virulence-associated genes, antibiotic resistance genes or integrases were detected in …

Assessment Of The Impact Of A Meningitis/Encephalitis Panel On Hospital Length Of Stay: A Systematic Review And Meta-Analysis, Kyle D Hueth, Philippe Thompson-Leduc, Todor I Totev, Katherine Milbers, Tristan T Timbrook, Noam Kirson, Rodrigo Hasbun

Faculty, Staff and Student Publications

Meningitis and encephalitis are central nervous system infections with considerable morbidity and mortality. The BioFire® FilmArray® Meningitis/Encephalitis Panel (multiplex ME panel) can identify pathogens rapidly potentially aiding in targeted therapy and curtail antimicrobial exposure. This systematic review and meta-analysis synthesized the literature on the association between the multiplex ME panel and length of hospital stay (LOS), length of acyclovir therapy, and days with antibiotics. MEDLINE and EMBASE were searched. Only studies presenting novel data were retained. Random-effects meta-analyses were performed to assess the impact of the multiplex ME panel on outcomes. Of 169 retrieved publications, 13 met the criteria for …