Digital Commons Network^™

Service Learning: A Case-Study Examining Positive And Negative Influences On Higher Education Faculty, Kathleen Reavy

Dissertations

The purpose of this research was, first, to study why a professor would implement and then continue to use a service learning methodology and, second, to study how a professor is shaped by service learning experiences. An in-depth case-study design was used to study the impacts of personal and contextual factors on one higher education professor implementing service learning in her classroom. Interviews, observations, and document reviews were used to gather data. The focal point for this study was a professor of a senior-level Nursing Leadership and Management course who successfully incorporated a service learning methodology and continues to do …

Clinical Cancer And Direct-To-Consumer Genetic Test Result-Sharing Behavior: Findings From Hints 2020, Sukh Makhnoon, Robert Yu, Susan K Peterson, Sanjay Shete

Faculty, Staff and Student Publications

INTRODUCTION: Sharing genetic test results with different stakeholders such as family members, healthcare providers and genetic counselors (HCP/GCs), spouses/partners, and friends is a health behavior of clinical importance in genomic medicine.

METHODS: Using nationally representative population-based data collected from the Health Information National Trends Survey (HINTS 5, cycle 4), we identified the prevalence and factors associated with genetic test result-sharing behavior for high-risk cancer tests, genetic health risk tests, and ancestry tests within four groups: HCP/GCs, first-degree relatives (FDRs), spouse/partner, and friend/other.

RESULTS: Overall, 68.4% of those who underwent high-risk cancer genetic testing shared their results with FDRs, whereas 89.9% …

Correlation Of Angiogenic Biomarkers To Tumor Progression And Angiogenesis In Cervical Cancer Cell (Caski)-Implanted Nude Mice, Nakorn Mathuradavong, Umarat Srisawat, Bhornprom Yoysungnoen, Nattapon Sookprasert

Asian Medical Journal and Alternative Medicine

Introduction: Several studies have indicated that microvascular density (MVD) and the expressions of angiogenic biomarkers were associated with tumor growth and angiogenesis in cervical cancer. However, the results were incomplete and inconsistent.

Objectives: To determine the correlation of the angiogenic biomarkers, including vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR), to tumor progression and angiogenesis in cervical cancer cell (CaSki)-implanted nude mice model.

Methods: 10×10⁶ of CaSki cells were injected into the female nude mice (n = 50) to establish subcutaneous tumors. The tumor size was measured every 3 days …

Index, - -

Asian Medical Journal and Alternative Medicine

No abstract provided.

Campaigners, Capitalizers, And Cooperators: A Typology Of Professional Identities Of Physician-Researchers Who Care For Patients While Recruiting Them To Industry-Sponsored Clinical Trials, Romiya Felecia Glover Barry

Doctor of Philosophy in Translational Health Sciences Dissertations

The critical phase for a successful clinical trial is timely accrual of research participants. Interventions to improve the outcome of recruiting activities have been developed to address the research structure of clinical trials, the administrative and design burdens of study protocols, the lack of awareness and acceptance of trials from patients and clinicians, and the insufficient research training for trial investigators. Engagement with potential clinical trial participants is lower than expected with a contributing factor being that investigators do not identify and approach all potential participants. The behaviors of physician-researchers responsible for recruiting and enrolling their patients into clinical trials …

Late-Stage Functionalization Through Click Chemistry Provides Glut5-Targeting Glycoconjugate As A Potential Pet Imaging Probe, Adelina Oronova, Marina Tanasova

Michigan Tech Publications, Part 1

The targeting of facilitative sugar transporters (GLUTs) has been utilized in the development of tools for diagnostics and therapy. The interest in this area is promoted by the phenomenon of alterations in cellular metabolic processes that are linked to multitudes of metabolic disorders and diseases. However, nonspecific targeting (e.g., glucose-transporting GLUTs) leads to a lack of disease detection efficiency. Among GLUTs, GLUT5 stands out as a prominent target for developing specific molecular tools due to its association with metabolic diseases, including cancer. This work reports a non-radiolabeled fluoride (19F) coumarin-based glycoconjugate of 2,5-anhydro-D-mannitol as a potential PET imaging probe that …

The Nutrition Prescription: Guideline Development For Nutrition Education In Graduate Nursing Curriculum, Jackie Myers, Samantha Delander

DNP and Student Works

Research describes nutrition education as "paramount" in reducing morbidity and mortality. There is a significant gap between current nutrition taught in graduate health science programs and the 25 hours of nutrition education suggested by the National Research Council. No standard nutrition education guideline exists. There is demand from students, graduate faculty, and legislators to incorporate nutrition knowledge into curricula as evident by the Medical Education Pledge signed at The White House's Conference on Hunger, Nutrition, and Health. Objectives: 1) Gap analysis of graduate health science nutrition education. 2) Develop and disseminate a nutrition guideline proposal for evaluation by stakeholders.

Implementing A Smoking Cessation Protocol In Type 2 Diabetics In A Podiatry Clinic Using The Five A'S Model, Guerlyne Henson

Dissertations

Smoking is an independent risk factor for DMT2 making it essential for providers to address smoking cessation consistently. The purpose of this quantitative, quasiexperimental quality improvement (QI) project was to evaluate if or to what degree the implementation of a tobacco cessation protocol using the Five A's model would impact the patient's motivation, nicotine dependence, and provider compliance with assessing tobacco use in adult diabetic smokers in a podiatry clinic for four weeks in the northeastern United States. The transtheoretical model (TTM) was utilized to evaluate patient motivation to quit smoking and determine appropriate cessation interventions. Data on the motivation …

“Model Minorities” In The Classroom? Positive Evaluation Bias Towards Asian Students And Its Consequences, Ying Shi, Maria Zhu

Center for Policy Research

The fast-growing demographic group of Asian Americans is often perceived as a “model minority.” This paper establishes empirical evidence of this stereotype in the context of education and then analyzes its consequences. We show that teachers rate Asian students’ academic skills more favorably than observationally similar White students in the same class, even after accounting for test performance and behavior. This contrasts with teachers’ lower likelihood of favoring Black and Hispanic students. Notably, teachers respond to the presence of any Asian student in the classroom by exacerbating Black-White and Hispanic-White assessment gaps. This suggests that the “model minority” stereotype can …

Acute Pain Management Pearls: A Focused Review For The Hospital Clinician., Sara J Hyland, Andrea M Wetshtein, Samantha J Grable, Michelle P Jackson

Pharmacy Articles

Acute pain management is a challenging area encountered by inpatient clinicians every day. While patient care is increasingly complex and costly in this realm, the availability of applicable specialists is waning. This narrative review seeks to support diverse hospital-based healthcare providers in refining and updating their acute pain management knowledge base through clinical pearls and point-of-care resources. Practical guidance is provided for the design and adjustment of inpatient multimodal analgesic regimens, including conventional and burgeoning non-opioid and opioid therapies. The importance of customized care plans for patients with preexisting opioid tolerance, chronic pain, or opioid use disorder is emphasized, and …

Online Clinical Post-Conference, Face-To-Face Clinical Post-Conference: Effects On Critical Thinking In Associate Degree Nursing Students, Kristie A. Berkstresser

Dissertations

Nurse educators, at every level of pre-licensure nursing education, are charged with developing critical thinking skills within their students. Post-clinical conference is one teaching strategy that nurse educators can employ to help promote the development of critical thinking skills in pre-licensure nursing students. However, traditional face-to-face post-clinical conference is marred with issues and concerns, as identified in the nursing education literature. An alternative to face-to-face post-clinical conference, asynchronous online learning environment, mitigates the issues and concerns associated with traditional post-clinical conference. Adult learning theory supports the use of asynchronous online learning environment. The asynchronous online learning environment promotes student-centered teaching …

A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal

Articles

With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the …

The Original “Market” Understanding Of The Commerce Clause: Insights From Early Federal Government Practice And Precedent, Robert J. Pushaw Jr.

BYU Law Review

No abstract provided.

Thai Traditional Medical Remedies In Worayokasarn Scripture For Treating Obesity, Pannawat Chaiyawathanananthn

Asian Medical Journal and Alternative Medicine

No abstract provided.

Fictional Escapism And Identity Formation: A Duoethnographic Exploration Of Stories And Adolescent Development, Cammie J. Lawton, Leia K. Cain

The Qualitative Report

Young Adult Literature has often been utilized to explore reader responses especially in attention to how fiction provides space to explore identity and one’s place within a larger societal context. In this duoethnography, we explored the importance of children and young adult literature’s influence on our own identity development. We share our primary findings that highlight the ways reading stories has provided escape, space for self-discovery and questioning, as well as pathways of learning to cultivate empathy and work towards social justice. We agree with Ellis’s (2014) argument that storytellers must share stories in a way that makes lessons or …

Hiv-Seropositive Patients’ Experiences With Social Workers: A South African Hiv+ Social Worker’S Reflective Log, Delarise Maud Mulqueeny

The Qualitative Report

Social workers play a pivotal role in HIV-seropositive patients’ treatment and care within South African public antiretroviral treatment (ART) programs. This article is a reflective log of an HIV-seropositive social worker’s observations and reflections on her positionality during a study on HIV-seropositive patients’ experiences of the public ART program in eThekwini, KwaZulu-Natal, South Africa. The primary investigator (PI) utilized various tools and techniques including reflexive bracketing, participatory action research and a reflexive diary to navigate a sensitive study. This was while being cognizant of the fluidity of her insider/outsider positionality. The disclosure of the PI’s HIV-seropositive status culminated in all …

Registry-Based Cohort Study Of Alpha-1 Antitrypsin Deficiency Prevalence, Incidence And Mortality In Denmark 2000-2018, John Acquavella, Emese Vágó, Henrik Toft Sorensen, Erzsébet Horváth-Puhó, Gregory P. Hess

College of Population Health Faculty Papers

OBJECTIVE: To estimate the prevalence of diagnosed alpha-1 antitrypsin deficiency (dAATD) in Denmark as of 31 December 2018, and dAATD incidence and mortality from 1 January 2000 to 31 December 2018.

STUDY DESIGN AND SETTING: We used the Danish National Patient Registry to identify patients with dAATD based on the International Classification of Diseases, 10th Revision (ICD-10) code E88.0A and the Danish Civil Registration System (CRS) for population counts and vital status. We estimated dAATD prevalence, incidence and mortality. We compared mortality among patients with dAATD and an age-matched and sex-matched cohort extracted from the Danish CRS. We conducted a …

White Matter Correlates Of Domain-Specific Working Memory, Autumn Horne, Junhua Ding, Tatiana T Schnur, Randi C Martin

Faculty, Staff and Student Publications

Prior evidence suggests domain-specific working memory (WM) buffers for maintaining phonological (i.e., speech sound) and semantic (i.e., meaning) information. The phonological WM buffer's proposed location is in the left supramarginal gyrus (SMG), whereas semantic WM has been related to the left inferior frontal gyrus (IFG), the middle frontal gyrus (MFG), and the angular gyrus (AG). However, less is known about the white matter correlates of phonological and semantic WM. We tested 45 individuals with left hemisphere brain damage on single word processing, phonological WM, and semantic WM tasks and obtained T1 and diffusion weighted neuroimaging. Virtual dissections were performed for …

Hif1a-Dependent Induction Of Alveolar Epithelial Pfkfb3 Dampens Acute Lung Injury, Christine U Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K Vladar, Christina Sul, Eric P Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S Nozik, Rubin M Tuder, Holger K Eltzschig

Faculty, Staff and Student Publications

Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar inflammation. We hypothesize that specific enzymes of the glycolytic pathway could function as key regulators of alveolar inflammation. Therefore, we screened isolated alveolar epithelia from mice exposed to ALI induced by injurious ventilation to assess their metabolic responses. These studies pointed us toward a selective role for isoform 3 of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3). Pharmacologic inhibition or genetic deletion of Pfkfb3 in alveolar epithelia (Pfkfb3loxP/loxP SPC-ER-Cre+ mice) was associated with profound increases in ALI during …

Robert Burns To Maria Riddell, A Lost Burns Manuscript And A Victorian Facsimile, Patrick Scott, Ronnie Young

Studies in Scottish Literature

Reviews the textual history of Robert Burns's brief letter to Maria Riddell, in spring 1795, in Dumfries, mentioning the miniature portrait by Alexander Reid; notes that the manuscript, owned in the late 19th century by Dr Thomas C.S. Corry of Belfast, and later by John Gribbel of Philadelphia, cannot now be located; and describes and illustrates the facsimile made of it in 1864 for Vincent Brooks in the Autographic Mirror, now the only source of this letter manuscript available to the Glasgow editorial team for the forthcoming Oxford edition of Burns's Correspondence.

Human Health During Space Travel: State-Of-The-Art Review, Chayakrit Krittanawong, Nitin Kumar Singh, Richard A Scheuring, Emmanuel Urquieta, Eric M Bershad, Timothy R Macaulay, Scott Kaplin, Carly Dunn, Stephen F Kry, Thais Russomano, Marc Shepanek, Raymond P Stowe, Andrew W Kirkpatrick, Timothy J Broderick, Jean D Sibonga, Andrew G Lee, Brian E Crucian

Faculty, Staff and Student Publications

The field of human space travel is in the midst of a dramatic revolution. Upcoming missions are looking to push the boundaries of space travel, with plans to travel for longer distances and durations than ever before. Both the National Aeronautics and Space Administration (NASA) and several commercial space companies (e.g., Blue Origin, SpaceX, Virgin Galactic) have already started the process of preparing for long-distance, long-duration space exploration and currently plan to explore inner solar planets (e.g., Mars) by the 2030s. With the emergence of space tourism, space travel has materialized as a potential new, exciting frontier of business, hospitality, …

Stereological Evidence Of Non-Selective Hippocampal Neurodegeneration, Igf-1 Depletion, And Behavioral Deficit Following Short Term Bilateral Adrenalectomy In Wistar Rats, Naserddine Hamadi, Ömür Gülsüm Deniz, Ahlam Said Abi Issa, Azim Ullah Shamsul Islam, Naheed Amir, Saeed Tariq Minhas, Nather Madjid, Fatima Khelifi-Touhami, Süleyman Kaplan, Abdu Adem

All Works

The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in albino rats. Such a model is one of the few noninvasive models for studying neurodegeneration. In the present study, using stereological technique and ultrastructural examination, we aimed to investigate the impact of short-term adrenalectomy (2 weeks) on different hippocampal neuronal populations in Wistar rats. In addition, the underlying mechanism(s) of degeneration in these neurons were investigated by measuring the levels of insulin-like …

Francisco Cedeno, Petitioner And Appellee V. Xochitl Cedeno, Respondent And Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

appeal from final contempt order of the Honorable G. Michael Westfall Of the Fifth Judicial District Court in and for Washington County, State of Utah Francisco I. Cedeno, Pro Se 1450 N Dixie Downs Road Trailer # 23 St. George, UT 84770

Of the Fifth Judicial District Court in and for Washington County, State of Utah Francisco I. Cedeno, Pro Se Trailer # 23 Kathryn Bliss Holt #5666 Boyack Christiansen Legal Solutions Attorney for Appellant

Work-Family Spillover And Depression: Are There Racial Differences Among Employed Women?, Ariane L. Rung, Evrim Oral, Edward S. Peters

School of Public Health Faculty Publications

The intersection of work and family life can be a source of burden (negative) and a source of growth (positive). Negative work-to-family and family-to-work spillover have been linked to poor mental health, while positive work-to-family and family-to-work spillover have been linked to improved health outcomes. Less is known about these relationships in racial subgroups. Louisiana, USA, has a large proportion of African Americans, providing a unique population in which to study these relationships. The objectives of this study were to examine, among a sample of women in southern Louisiana in 2017, levels of work-family spillover by race and how the …

Period 2 Regulates Low-Dose Radioprotection Via Per2/Pgsk3Β/Β-Catenin/Per2 Loop, Aris T Alexandrou, Yixin Duan, Shanxiu Xu, Clifford Tepper, Ming Fan, Jason Tang, Jonathan Berg, Wassim Basheer, Tyler Valicenti, Paul F Wilson, Matthew A Coleman, Andrew T Vaughan, Loning Fu, David J Grdina, Jefferey Murley, Aijun Wang, Gayle Woloschak, Jian Jian Li

Faculty, Staff and Students Publications

During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level radiation (LDR). It is unclear, however, if clock proteins participate in signaling LDR radioprotection. Herein, we demonstrate that radiosensitivity is increased in mice with the deficient Period 2 gene (Per2def) due to impaired DNA repair and mitochondrial function in progenitor bone marrow hematopoietic stem cells and monocytes. Per2 induction and radioprotection are also identified in LDR-treated Per2wt mouse cells and in human skin (HK18) and breast (MCF-10A) …

The Discrimination Of Self From Other As A Component Of Empathy., Charlotte Little, Elizaveta Solomonova, Maiya Jordan, Natalie Klein, Ben Jennings, Gunnar Schmidtmann, Héctor Leos, Ian Gold

School of Health Professions

Despite the centrality of empathy in human social life, there is no widely agreed definition or characterization of the concept of empathy. A common thread in many of the proposed definitions, however, is that empathy presupposes the discrimination of self and other on the grounds that, to empathize with another individual, the mental state of the target individual must first be distinguished from the empathizer's own mental state. The purpose of this study is to investigate this proposal empirically. We employed a paradigm in which participants rated the emotional valence and degree of arousal of 93 facial expressions of mental …

Use Of An Invertebrate Animal Model (Aplysia Californica) To Develop Novel Neural Interfaces For Neuromodulation, Junqi Zhuo, Jeffrey P. Gill, Michael W. Jenkins, Hillel J. Chiel

Faculty Scholarship

New tools for monitoring and manipulating neural activity have been developed with steadily improving functionality, specificity, and reliability, which are critical both for mapping neural circuits and treating neurological diseases. This review focuses on the use of an invertebrate animal, the marine mollusk Aplysia californica, in the development of novel neurotechniques. We review the basic physiological properties of Aplysia neurons and discuss the specific aspects that make it advantageous for developing novel neural interfaces: First, Aplysia nerves consist only of unmyelinated axons with various diameters, providing a particularly useful model of the unmyelinated C fibers in vertebrates that are known …

Aptamer Proteomics Of Serum Exosomes From Patients With Primary Raynaud's And Patients With Raynaud's At Risk Of Evolving Into Systemic Sclerosis, Sonsoles Piera-Velazquez, Simon T. Dillon, Xuesong Gu, Towia A. Libermann, Sergio A. Jimenez

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: A major unmet need for Systemic Sclerosis (SSc) clinical management is the lack of biomarkers for the early diagnosis of patients with Raynaud's Phenomenon at high risk of evolving into SSc.

OBJECTIVE: To identify proteins contained within serum exosomes employing an aptamer proteomic analysis that may serve to reveal patients with Raynaud's Phenomenon at risk of developing SSc.

METHODS: Exosomes were isolated from serum samples from patients with Primary Raynaud's Phenomenon and from patients with Raynaud's Phenomenon harbouring serum antinuclear antibodies (ANA) who may be at high risk of evolving into SSc. The expression of 1,305 proteins was quantified …

Rare Diseases And Space Health: Optimizing Synergies From Scientific Questions To Care, Maria Puscas, Gabrielle Martineau, Gurjot Bhella, Penelope E Bonnen, Phil Carr, Robyn Lim, John Mitchell, Matthew Osmond, Emmanuel Urquieta, Jaime Flamenbaum, Giuseppe Iaria, Yann Joly, Étienne Richer, Joan Saary, David Saint-Jacques, Nicole Buckley, Etienne Low-Decarie

Faculty, Staff and Students Publications

Knowledge transfer among research disciplines can lead to substantial research progress. At first glance, astronaut health and rare diseases may be seen as having little common ground for such an exchange. However, deleterious health conditions linked to human space exploration may well be considered as a narrow sub-category of rare diseases. Here, we compare and contrast research and healthcare in the contexts of rare diseases and space health and identify common barriers and avenues of improvement. The prevalent genetic basis of most rare disorders contrasts sharply with the occupational considerations required to sustain human health in space. Nevertheless small sample …

Engineering Naturally Occurring Cd7- T Cells For The Immunotherapy Of Hematological Malignancies, Abdullah Freiwan, Jaquelyn T Zoine, Jeremy Chase Crawford, Abishek Vaidya, Stefan A Schattgen, Jacquelyn A Myers, Sagar L Patil, Mahsa Khanlari, Hiroto Inaba, Jeffery M Klco, Charles G Mullighan, Giedre Krenciute, Peter J Chockley, Swati Naik, Deanna M Langfitt, Maksim Mamonkin, Esther A Obeng, Paul G Thomas, Stephen Gottschalk, M Paulina Velasquez

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR) T-cell therapy targeting T-cell acute lymphoblastic leukemia (T-ALL) faces limitations such as antigen selection and limited T-cell persistence. CD7 is an attractive antigen for targeting T-ALL, but overlapping expression on healthy T cells leads to fratricide of CD7-CAR T cells, requiring additional genetic modification. We took advantage of naturally occurring CD7- T cells to generate CD7-CAR (CD7-CARCD7-) T cells. CD7-CARCD7- T cells exhibited a predominantly CD4+ memory phenotype and had significant antitumor activity upon chronic antigen exposure in vitro and in xenograft mouse models. Based on these encouraging results, we next explored the utility of CD7- …