Digital Commons Network^™

The Potential Of Liquid For Breast Cancer: A Review, Sonar Soni Panigoro, Clarissa Kezia Yuella -

The New Ropanasuri Journal of Surgery

Introduction. Tissue biopsy is the current gold standard for cancer diagnosis, targeted treatment, and prognosis. However, biopsy is an invasive procedure that could result in postoperative bleeding, pain, and infection. Such limitations may now be resolved by the clinical technique known as liquid biopsy, which enables a better representation of disease status.

Method. This literature review was conducted through online databases (PubMed, Ascopubs, EuroPMC) using the following keywords: "liquid biopsy", "ctDNA", "CTC", "breast cancer", "pathogenesis of breast cancer", "tumor microenvironment”, “ctdna detection technologies”, "early diagnosis", "targeted therapy" ,"monitoring disease progression”, and "prognosis”. The literature search was conducted using the PRISMA …

Chemical And Biological Stability Under Forced Degradation And Accelerated Storage Conditions Of The Anti-Acne Formulation Of Pra-Sa-Mang-Khud Ethanolic Extract, Kalyarut Phumlek, Arunporn Itharat, Ubonwan Saesiw, Weerachai Pipatrattanaseree, Krit Piwngam

Asian Medical Journal and Alternative Medicine

Introduction: Pra-Sa-Mang-Khud (PSM) formula is the mixture of Garcinia mangostana pericarp and Ha-Rak remedy developed for acne treatment. However, the chemical and biological stability of PSM extract is necessary for an optimal manufacturing process. Therefore, this study was aimed to investigate the stability of PSM ethanolic extract under forced degradation and accelerated storage conditions.
Methods: Thermal degradation, moisture hydrolysis, acid hydrolysis, alkaline hydrolysis, and oxidation were performed in forced degradation studies. In addition, PSM extract was kept in accelerated storage conditions at 40 ± 2ºC with 75 ± 5% RH for 6 months. Finally, PSM extracts under forced degradation and …

Cytotoxic Activity On Colorectal Cancer Cells And Antioxidant Activity Of Crude Extracts Of Pi-Kad-Tri-Khan-Tha-Wart Remedy And Its Component, Katanchalee Houngiam, Arunporn Itharat, Bhanuz Dechayont, Pathompong Phuaklee, Jitpisute Chunthorng-Orn

Asian Medical Journal and Alternative Medicine

Introduction: Pi-Kad-Tri-Khan-Tha-Wart (PK) is a Thai traditional remedy utilizing for gastrointestinal tract disorder such as nausea vomiting stomachache. It consists of three medicinal plants. Two ingredients of the remedy, nutmeg (seed of Myristica fragrans Houtt., MF) and clove (flower buds of Syzygium aromaticum (L.) Merr. & L.M. Perry., SA), had anti-inflammation, antioxidation and cytotoxic property against breast cancer cells (MCF-7). Fruit of Amomum xanthioides Wall. (AX) had cytotoxicity against ovarian cancer cells (SK-OV-3) and malignant melanoma cells (SK-MEL-2). This study investigated the cytotoxicity against colorectal cancer cells and antioxidant of the Pi-Kad-Tri-Khan-Tha-Wart remedy and its components.

Methods: The remedy and …

Genotoxic, Antigenotoxic, And Antioxidative Potentials Of Thai Bee Products, Treetip Ratanavalachai, Wantha Jenkhetkan, Chalerm Jansom, Arunporn Itharat, Sumon Thitiorul

Asian Medical Journal and Alternative Medicine

Introduction: Bee products are becoming increasingly used as nutritional supplements. They have been reported to have antibacterial and antitumor properties.

Objective: We aimed to compare the efficacies on antioxidative and antigenotoxic potentials among these products from Chiangmai, northern Thailand, including their genotoxicity.

Methods: The genotoxicity and antigenotoxicity were assessed using in vitro sister chromatid exchange assay in human lymphocytes. Chemical compositions and antioxidative activities were investigated using standard chemical methods.

Results: Our results revealed that the lipid extracts tended to have the least genotoxicity compared to their defatted and crude extracts. The lipid extract of propolis at a nongenotoxic dose …

Probiotic Supplementations Preserve Protective Immunity Against Sars-Cov-2 Spike Protein After A Triple Combination Of Covid-19 Vaccination, Aphitchaya Chanbunyavit, Vitoon Jularattanaporn, Thamthiwat Nararatwanchai

Asian Medical Journal and Alternative Medicine

Introduction: Immunoglobulin G against SARS-CoV-2 spike protein declines over-time in vaccinated individuals. Trend to restore protective immunity is challenging.

Objectives: Probiotics have beneficial effects to human innate and adaptive immune responses. This study aimed to compare immune preservation of probiotic supplement versus placebo by measuring the mean and percent reduction of COVID-19 antibody level among those subjects receiving a triple dose combination of COVID-19 vaccine.

Methods: A randomized, double-blinded, placebo-controlled trial, conducted in Bangkok-Samui hospital between December 2021 to February 2022. There were 30 volunteers, divided randomly into 2 groups. The target group received probiotics supplement once daily for 6 …

The Effectiveness Of Mind Map As A Teaching Tool For Medical Students, Sidayu Suriya, Nuntra Suwantarat, Vorawan Vanicharoenchai, Cherdsak Iramaneerat

Asian Medical Journal and Alternative Medicine

Objective: The mind map has been proven for improving learning effectiveness. We hypothesized that the mind map is helpful to enhance learning outcomes by increasing knowledge retention and student perception for 3^rd year medical students at the Faculty of Medicine, Naresuan University.

Methods: A randomized controlled trial study was conducted by comparing the academic performance (MCQs scores for pre-test, immediate post-test, and delayed post-test) and the improvement in academic performance in each group by using the paired t test and the students’ perception survey (Assessing Student Perspective of Engagement in Class Tool, ASPECT) after attending the class of “osteoporosis” …

How Does Allium Leafy Parts Metabolome Differ In Context To Edible Or Inedible Taxa? Case Study In Seven Allium Species As Analyzed Using Ms-Based Metabolomics, Mostafa H. Baky, Samir N. Shamma, Mohamed R. Khalifa, Mohamed A. Farag

Faculty Journal Articles

Genus Allium (F. Amaryllidaceae) includes a wide variety of edible foods widely consumed for their nutritive as well as health benefits. Seven Allium species, viz., chives, Egyptian leek, French leek, red garlic, white garlic, red onion, and white onion aerial parts were assessed for metabolome heterogeneity targeting both aroma and nutrients phytochemicals. A headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) were employed. Results revealed extensive variation in volatiles and nutrients profile among the seven Allium species represented by a total of 77 nutrients and 148 volatiles. Among edible Allium species, French leek encompassed high levels of nutrients, viz., …

Grendel's Mother, Zoe M. Lasden-Lyman

Theses and Dissertations

She helps all the humans and animals in her building. Then why won't she answer this strange, new knocking at her apartment door? A bizarre thriller about the world right now... and about cats.

Evaluation And Revision Of The Practice Environment Scale Of The Nursing Work Index For Acute Care Hospital Staff Nurses, Caitlin M. Campbell

Dissertations

The Practice Environment Scale of the Nursing Work Index (PES-NWI) is the most frequently used instrument for measuring the nursing work environment. The original PES-NWI obtained its items directly from the parent instrument, the Nursing Work Index, which was developed in the 1980s. However, potential value change among younger generations and vast historical, social, and technological transformations in the way healthcare is provided may have led to different factors that compose a favorable work environment for nurses working today.

Verge: A Collection Of Poems, Alexandria Machado

Master’s Theses and Projects

No abstract provided.

Reindeer From Alaska Are Brought To Sun Valley, John W. Lundin

Works by Local Authors

No abstract provided.

The Weekly Challenger, December 22, 2022, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 22, 2022, issue of The Weekly Challenger.

Robust Dynamic Space-Time Panel Data Models Using Ε- Contamination: An Application To Crop Yields And Climate Change, Badi H. Baltagi, Georges Bresson, Anoop Chaturvedi, Guy Lacroix

Center for Policy Research

This paper extends the Baltagi et al. (2018, 2021) static and dynamic ε-contamination papers to dynamic space-time models. We investigate the robustness of Bayesian panel data models to possible misspecification of the prior distribution. The proposed robust Bayesian approach de-parts from the standard Bayesian framework in two ways. First, we consider the ε-contamination class of prior distributions for the model parameters as well as for the individual effects. Second, both the base elicited priors and the ε-contamination priors use Zellner (1986)’s g-priors for the variance-covariance matrices. We propose a general “toolbox” for a wide range of specifications which includes the …

Niche Modeling Of Eight Crayfish Species In Texas, Nathan Schubert

Biology Theses

Freshwater species make up ~10% of all known species and occupy less than one percent of earth’s habitat, which is being degraded by human usage. Crayfish have a large impact on their aquatic or terrestrial environment and can serve as a health indicator of aquatic environments, as they generally require undegraded environments. In many habitats, crayfish make up more than half of the macroinvertebrate biomass, and play important ecological roles, as a food resource for both aquatic and terrestrial species, as predators of fish and invertebrates, and as bioprocessors of vegetation and detritus. The objective of this project was to …

The Impact On Gay Men Of Support And Enforcement Of Workplace Dei Policies: A Meta Analysis, Steven M. Vega

Student Theses and Dissertations

The poor enforcement of workplace DEI policies affects gay men in ways that are unique and invite close attention. The nature of the impact of missing or unsupported DEI policies on gay men has been widely debated in the field of human resources and communication studies, with scholars such as David Wicks, Helen Seitzer, James Ward, and Diana Winstansley arguing that these effects include lasting negative mental and physical health effects and discomfort with self-disclosure in the workplace. However, the existing research on this topic has not sufficiently considered the effects of the poor enforcement of workplace DEI policies side …

Investigation, Detection And Prevention Of Online Child Sexual Abuse Material: A Comprehensive Survey, Vuong Ngo, Christina Thorpe, Cach N. Dang, Susan Mckeever

Conference papers

Child sexual abuse inflicts lifelong devastating consequences for victims and is a growing social concern. In most countries, child sexual abuse material (CSAM) distribution is illegal. As a result, there are many research papers in the literature which proposed technologies to detect and investigate CSAM. In this survey, a comprehensive search of the peer reviewed journal and conference paper databases (including preprints) is conducted to identify high-quality literature. We use the PRISMA methodology to refine our search space to 2,761 papers published by Springer, Elsevier, IEEE and ACM. After iterative reviews of title, abstract and full text for relevance to …

The Fiscal Sustainability Of Retiree Health Care Benefits Among New York State School Districts, Robert Bifulco, Minch Lewis, Iuliia Shybalkina

Center for Policy Research

We examine spending on retiree health care as a percentage of revenues for a sample of New York State school districts. The fiscal burden of these benefits grew from 2010 to 2021, and big city school districts have faced the largest burdens. Assuming CBO forecasts regarding growth in health care costs and continuation of recent trends in revenue growth, we project that the burden of retiree health care benefits will exceed 10 percent of revenue by 2050. Projected burdens are greatest big city and high need rural districts. We discuss cutting benefits and pre-funding as possible policy responses.

Stakeholder Perspectives On The Demand And Supply Factors Driving Substandard And Falsified Blood Pressure Lowering Medications In Nigeria: A Qualitative Study, Grace Shedul, Olutobi Adekunle Sanuade, Eugenia N Ugwuneji, Tunde M Ojo, Aishwarya Vijay, Patrick Ponzing, Inuwa Okpe, Gabriel Lamkur Shedul, Mark D Huffman, Dike Ojji, Lisa R Hirschhorn

2020-Current year OA Pubs

OBJECTIVES: Although substandard and falsified (SF) blood pressure (BP) lowering medications are a global problem, qualitative research exploring factors driving this in Nigeria has not been reported. This study provides information on factors driving demand for and supply of low-quality BP lowering medications in Nigeria and potential strategies to address these factors.

METHODS: This was a cross-sectional qualitative study. Between August 2020 and September 2020, we conducted 11 in-depth interviews and 7 focus group discussions with administrators of health facilities, major manufacturers and distributors of BP lowering medications, pharmacists, drug regulators, patients and primary care physicians purposively sampled from the …

Myocardial Contractility Pattern Characterization In Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study With Contractix, El-Sayed H Ibrahim, Antonio Sosa, Sherry-Ann Brown, Dayeong An, Slade Klawikowski, John Baker, Carmen Bergom

2020-Current year OA Pubs

Radiation therapy (RT) plays an integral role in treating thoracic cancers, despite the risk of radiation-induced cardiotoxicity. We hypothesize that our newly developed magnetic resonance imaging (MRI)-based contractility index (ContractiX) is a sensitive marker for early detection of RT-induced cardiotoxicity in a preclinical rat model of thoracic cancer RT. Adult salt-sensitive rats received image-guided heart RT and were imaged with MRI at 8 weeks and 10 weeks post-RT or sham. The MRI exam included cine and tagging sequences to measure left-ventricular ejection fraction (LVEF), mass, myocardial strain, and ContractiX. Furthermore, ventricular torsion, diastolic strain rate, and mechanical dyssynchrony were measured. …

Effectiveness Of Soluble Ctla-4-Fc In The Inhibition Of Bone Marrow T-Cell Activation In Context Of Indoleamine 2.3-Dioxygenase (Ido) And Cd4+Foxp3+ Treg Induction, Magdalena Massalska, Marzena Ciechomska, Ewa Kuca-Warnawin, Tomasz Burakowski, Anna Kornatka, Anna Radzikowska, Dariusz Pawlak, Barbara Muz, Adrianna Loniewska-Lwowska, Andrzej Palucha, Pawel Maldyk, Wlodzimierz Maslinski

2020-Current year OA Pubs

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease with systemic inflammation finally resulting in damaged joints. One of the RA development models suggests bone marrow (BM) as a place of inflammation development further leading to disease progression. We aimed to investigate the potential of CTLA-4-Fc molecule in inducing tolerogenic milieu in BM measured as indoleamine 2,3-dioxygenase (IDO) expression, CD4

METHODS: Bone marrow mononuclear cells (BMMC) were stimulated by pro-inflammatory cytokines and CTLA-4-Fc. Next IDO expression, CD4

RESULTS: We found that CTLA-4-Fc and IFN-γ stimulation results in IDO production by BMMC. CTLA-4-Fc induced tryptophan catabolism can inhibit mitogen-induced CD4

CONCLUSION: …

On Kernel-Based Estimator Of Odds Ratio Using Different Stratified Sampling Schemes, Abbas Eftekharian, Hani Samawi, Haresh Rochani

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

The kernel-based estimator of Cochran Mantel-Haenszel odds ratio based on stratified simple and ranked set sampling is proposed. The expectation and variance of the estimator are analytically obtained. Using a simulation study, the estimator based on stratified ranked set sampling is more efficient than its counterpart based on stratified simple random sampling. Finally, the estimator's performance is investigated by using base deficit data.

Identifying The Gaps Between Public Health Training And Practice: A Workforce Competencies Comparative Analysis, Osnat Bashkin, Robert Otok, Ori Kapra, Kasia Czabanowska, Paul Barach, Orna Baron-Epel, Keren Dopelt, Mariusz Duplaga, Lore Leighton, Hagai Levine, Fiona Macleod, Yehuda Neumark, Stephanie Paillard-Borg, Theodore Tulchinsky, Zohar Mor

College of Population Health Faculty Papers

Objectives: The study aimed to generate insights on how best to enhance the compatibility between Public Health training program competencies and the implementation of competencies required by employers to address current and emerging public health needs.

Methods: A survey adapted from the WHO-ASPHER Competency Framework for the Public Health Workforce was conducted online among Israeli public health managers from August to November 2021. The survey was formulated to mirror Essential Public Health Operations. Forty-nine managers participated (37.6% response rate) in an assessment of 44 public health competencies and the core organizational public health operations.

Results: Analysis of Essential Public Health …

Camaraderie, Mentorship, And Manhood: Contemporary Indigenous Identities Among The A’Uwẽ (Xavante) Of Central Brazil, James R. Welch

Tipití: Journal of the Society for the Anthropology of Lowland South America

Rites of passage and associated social processes and configurations can foster a sense of shared purpose, fraternity, and dedication to community through common experiences of group trials and commitment. A’uwẽ (Xavante) age organization entails the social production of manhood through a privileged form of male camaraderie constructed through age sets and mentorship, rooted in the shared experience of rites of passage and coresidence in the pre-initiate boys’ house. This process is central to how A’uwẽ men understand themselves, their social relations with certain delineated segments of society, and their ethnic identity. It is a basic social configuration contributing to the …

2022-December-22-Etsu Celebrates The Class Of 2022, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (December 10, 2022) – East Tennessee State University celebrated more than 1,500 members of the Class of 2022 during two Commencement ceremonies held at the Ballad Health Athletic Center today.

During the morning ceremony, Dr. Cerrone Foster, recipient of the university’s 2022 Distinguished Faculty Award in Teaching, was the keynote speaker. Foster, who was also a recipient of the 2022 Notable Women of ETSU award, encouraged the graduates to do big things, do good things and do hard things.

“You navigated the before and after of a pandemic; you navigated the ups and downs of it, and you …

A Recovery Pathway After Covid-19 Teacher Burnout, Laura Sokal, Lesley Eblie Trudel

Journal of Social, Behavioral, and Health Sciences

Burnout in the helping professions, including teaching, has been well documented for over fifty years and has been captured within two seminal models offered by Maslach and her colleagues. For this study we interviewed 22 teachers bi-weekly to determine whether these models captured their COVID-19 pandemic work experiences during the 2020–2021 school year. Only one teacher, however, left work on a medical leave and then returned to work after burning out, and therefore provided a case study of the processes of both teacher burnout and recovery under pandemic conditions. The existing models of burnout were upheld as salient in understanding …

Appendices To Inglis, Octonaries: Titles And Dedications From Other Mss, Mss Containing The ‘G.D.’ And ‘Velde’ Sonnets, Who Was ‘G.D.’?, Jamie Reid Baxter

Studies in Scottish Literature

Three Appendices to the preceding article on Esther Inglis's Octonaries: (1) transcribe the Titles and Dedications in other manuscripts; (2) record the five MSS containing the ‘G.D.’ and ‘Velde’ Sonnets discussed in the article; and (3) review possibilities for the identity of 'G.D.', proposing that it was George Douglas, a gifted vernacular poet and translator of Boethius.NOTE: the current file (August 9 2023) includes further minor corrections. Please refresh your browser if you downloaded a previous version. SSL Ed.

Burns And Jean Armour, Ellisland, 1788: A Letter Fragment In The Roy Collection, Patrick Scott

Studies in Scottish Literature

Describes and illustrates a two-sided fragment of Robert Burns's letter from Ellisland to his wife Jean Armour, in Muchline, from September 12, 1788, concerning her move to join him, and news for his brother Gilbert. Only four letters from Burns to Jean are now known; the main body of this letter was printed by Waddell in 1869, and was later recorded in the Honresfield Collection (now the Blavatnik-Honresfield Collection), but this section, now in the G. Ross Roy Collection at the University of South Carolina, was snipped off by the then-owner Mary MacLaughlan Nicolson for a collector before Waddell saw …

Cocaine Sensitizes The Cd4+ T Cells For Hiv Infection By Co-Stimulating Nfat And Ap-1, Adhikarimayum Lakhikumar Sharma, Dylan Shafer, Daniel Netting, Mudit Tyagi

Center for Translational Medicine Faculty Papers

The productive infection of HIV, which generates new viral progeny, depends on the activation status of the cell. In this study, we found cocaine exposure sensitizes partially active CD4+ T cells and makes them poised for productive HIV infection. We discovered that cocaine treatment enhances the metabolic state of the cells by co-stimulating several transcription factors, mainly NFAT and AP-1, the two transcription factors, which specifically play a crucial role in enhancing both HIV and the overall cellular gene expression in T cells. We found that cocaine-induced AP-1 works in tandem with NFAT to boost HIV transcription. The enhanced HIV …

Nonconsensual Family Obligations, Emily J. Stolzenberg

BYU Law Review

Even as the pandemic has both highlighted and compounded the challenges many U.S. families face in meeting their members’ basic needs, efforts to expand public subsidies for caretaking have gained little traction. Scholars have identified many historical and practical reasons for Americans’ entrenched skepticism toward the welfare state. Ideas matter, too, and this Article uncovers and critiques one that works to limit collective financial responsibility for families: the conviction that family support obligations must be legitimated through consent.

In family law, as in liberal political theory, consent works to reconcile state regulation with individual freedom. But because consent is a …

Providing Education And Resources To Staff Working With Adult Victims Of Intimate Partner Violence Experiencing Homelessness, Jillian Edling, Courtney Schultze, Sarah Scott

DNP and Student Works

Homelessness impacts over half a million individuals in the United States and increases the risk of physical, emotional, social, and financial distress, potentially leading to violence, abuse or harm. Individuals experiencing intimate partner violence (IPV) are at an increased risk of becoming homeless. Homeless shelters in Duluth, MN, without specific IPV focus, do not have formal IPV training in place. The goal of this project was to educate staff and volunteers at a warming center in Duluth, MN on how to identify IPV, implement an evidence-based screening tool, and provide appropriate resource referrals to victims of IPV.