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2022

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Creating And Implementing A Covid-19 Prevention And Response Program In The Performing Arts: A Clinician Expertise Commentary, David Tomchuk, Kyle Schneider, Jacklyn Bascomb-Harrison Jan 2022

Creating And Implementing A Covid-19 Prevention And Response Program In The Performing Arts: A Clinician Expertise Commentary, David Tomchuk, Kyle Schneider, Jacklyn Bascomb-Harrison

Clinical Practice in Athletic Training

No abstract provided.


Exertional Heat Stroke In A Male High School Runner With Disordered Eating: A Disablement Model Case Study, Brittni G. Hoover, Rebecca M. Hirschhorn, Allison B. Smith, Amy F. Hand Jan 2022

Exertional Heat Stroke In A Male High School Runner With Disordered Eating: A Disablement Model Case Study, Brittni G. Hoover, Rebecca M. Hirschhorn, Allison B. Smith, Amy F. Hand

Clinical Practice in Athletic Training

A 16-year-old male high school cross country athlete collapsed at the end of an afternoon 5K cross country meet. The patient was unable to stand, and after outwardly displaying confusion and agitation, his coaches sought assistance from the athletic trainers (ATs). The patient consumed one cup of water and a granola bar on the day of the meet. The ambient air temperature was 90°F with 69% humidity. Differential diagnoses included exertional heat stroke (EHS), exertional heat exhaustion, exertional collapse associated with sickle cell trait, heat syncope, dehydration, malnutrition, and hypoglycemia. Approximately 20 minutes passed between activation of the emergency action …


The Increased Push For Implementing Caate Diversity, Equity, And Inclusion Standards In The Southwest Athletic Trainers’ Association (Swata), Luzita Vela, Meredith Decker, Ramonica Scott, Brandon Warner, Shaketha Pierce Jan 2022

The Increased Push For Implementing Caate Diversity, Equity, And Inclusion Standards In The Southwest Athletic Trainers’ Association (Swata), Luzita Vela, Meredith Decker, Ramonica Scott, Brandon Warner, Shaketha Pierce

Clinical Practice in Athletic Training

No abstract provided.


Characteristics Of Sickle Cell Trait Policies And Procedures At Ncaa Division I Institutions, H Parker, B J. Warner, D M. Gallegos, S A. Cage Jan 2022

Characteristics Of Sickle Cell Trait Policies And Procedures At Ncaa Division I Institutions, H Parker, B J. Warner, D M. Gallegos, S A. Cage

Clinical Practice in Athletic Training

Context: In 2010, the National Collegiate Athletic Association (NCAA) introduced a proposal addressing sickle cell trait screening. This proposal later became a policy that required student-athletes in their first year of eligibility to provide their institution with accurate information regarding their sickle cell trait status. There does not appear to be a recent study published that has examined the sickle cell trait policies and procedures currently being used by NCAA Division I institutions. The purpose of this study was to describe the characteristics of sickle cell trait policies and procedures at NCAA Division I institutions. Methods: We used a web-based …


Raman Spectroscopy Reveals Phenotype Switches In Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman Jan 2022

Raman Spectroscopy Reveals Phenotype Switches In Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman

Biomedical Engineering Faculty Publications and Presentations

The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling metastatic progression of cancer. Here, we report a label-free optical strategy using Raman spectroscopy and machine learning to identify distinct metastatic phenotypes observed in tumors formed by isogenic murine breast cancer cell lines of progressively increasing metastatic propensities. Methods: We employed the 4T1 isogenic panel of murine breast cancer cells to grow tumors of varying metastatic potential and acquired label-free spectra using a fiber probe-based portable Raman spectroscopy system. We used MCR-ALS and random forests classifiers to identify putative spectral …


A Qualitative Study To Explore The Acceptability And Usefulness Of Personalized Biofeedback To Motivate Physical Activity In Cancer Survivors, Grace E. Brannon, Madison Ray, Patrick Cho, Miranda Baum, Muhammad Shaalan Beg, Therese Bevers, Susan M. Schembre, Karen Basen-Engquist, Yue Liao Jan 2022

A Qualitative Study To Explore The Acceptability And Usefulness Of Personalized Biofeedback To Motivate Physical Activity In Cancer Survivors, Grace E. Brannon, Madison Ray, Patrick Cho, Miranda Baum, Muhammad Shaalan Beg, Therese Bevers, Susan M. Schembre, Karen Basen-Engquist, Yue Liao

SAGE Open Access Agreement Publications-Archive

Objective: Many cancer survivors do not meet recommended levels of exercise, despite the benefits physical activity offers. This study aimed to understand experiences of insufficiently active overweight/obese breast or colorectal cancer survivors, in efforts to (1) examine regular physical activity barriers, and (2) determine perceptions and acceptability of a remotely delivered physical activity intervention utilizing wearable sensors and personalized feedback messages.


Management Of Gastroesophageal Reflux Disease (Gerd) By Primary Care Providers In Mississippi, Kimberly S. Fernando, Claire E. Harrelson, Alisha D. Jones, Kasey M. Rowley, Reagan L. Walker Jan 2022

Management Of Gastroesophageal Reflux Disease (Gerd) By Primary Care Providers In Mississippi, Kimberly S. Fernando, Claire E. Harrelson, Alisha D. Jones, Kasey M. Rowley, Reagan L. Walker

MSN Research Projects

Gastroesophageal reflux disease (GERD) is one of the most common diseases seen in primary care practice. To reduce the negative effects, such as esophageal narrowing, erosions, and precancerous lesions, from uncontrolled or inadequately managed GERD, primary care providers must stay up to date on evidence-based research and integrate the most current guidelines, The American College of Gastroenterology (ACG) updated guidelines for proper management of GERD in 2021, into practice. The guidelines recommend lifestyle modifications, proper pharmacological treatment with proton pump inhibitors (PPIs) for an eight-week course, and proper follow-up and/or referral if unimproved. The purpose of this research study was …


Climate Adaptation For Tropical Island Land Stewardship: Adapting A Workshop Planning Process To Hawai'i, Ryan J. Longman, Courtney L. Peterson, Madeline Baroli, Abby G. Frazier, Zachary Cook, Elliott W. Parsons, Maude Dinan, Katie L. Kamelamela, Caitriana Steele, Reanna Burnett, Chris Swanston, Christian P. Giardina Jan 2022

Climate Adaptation For Tropical Island Land Stewardship: Adapting A Workshop Planning Process To Hawai'i, Ryan J. Longman, Courtney L. Peterson, Madeline Baroli, Abby G. Frazier, Zachary Cook, Elliott W. Parsons, Maude Dinan, Katie L. Kamelamela, Caitriana Steele, Reanna Burnett, Chris Swanston, Christian P. Giardina

Geography

No abstract provided.


Counterstories Of High School Black Males And Their Experiences Of The Mainstream Curricula, Kayla Turner Jan 2022

Counterstories Of High School Black Males And Their Experiences Of The Mainstream Curricula, Kayla Turner

College of Graduate Studies: Theses & Dissertations

This is an inquiry into the experiences Black males have with the current high school curricula. Theoretically drawing on critical race theory (Bell, 1992; Delgado, 1995; Dixson & Rousseau, 2006; Ladson-Billings, 2009; Solórzano & Yosso, 2001, 2004), I explore how high school Black males’ suggestions and ideas can be used to shift the current curricula to a curricula that is more culturally sustaining. I challenge deficit research on Black male learners by focusing on the educational successes of Black males. Methodologically, I utilize counterstorytelling (Delgado, 2017; Solórzano & Yosso, 2002) to illustrate the experiences of three academically successful high school …


Stress, Stress Appraisal And Coping In Athletic Trainers During The Covid-19 Pandemic, Lawson Holton Jan 2022

Stress, Stress Appraisal And Coping In Athletic Trainers During The Covid-19 Pandemic, Lawson Holton

College of Graduate Studies: Theses & Dissertations

Introduction: There have been many studies conducted on the stress and mental health of frontline healthcare workers (HCWs) over the past months since the COVID-19 pandemic began. Very limited literature has examined the effect of the pandemic on athletic trainers (ATs). Objective: The aim of this investigation was to examine the stress, stress appraisal, and coping measures of ATs during the COVID-19 pandemic. Methods: Participants were recruited members from the National Athletic Trainers’ Association (NATA). The Perceived Stress Scale-10 was used to measure stress, the Stress Appraisal Measure was used to measure stress appraisal, and the Brief COPE was used …


Exploring Sport, Exercise, And Performance Psychology Practitioners’ Attitudes On Attire, Claire Harding Jan 2022

Exploring Sport, Exercise, And Performance Psychology Practitioners’ Attitudes On Attire, Claire Harding

College of Graduate Studies: Theses & Dissertations

Research has revealed that attire has an influence on one’s self-perceptions, self and socially prescribed adjective traits and behavior (Adam & Galinsky, 2012; Lubker et. al, 2008; Peluchette & Karl, 2007). The present study aims to explore the influence of attire on perceptions, attitudes, and experiences of SEPP (Sport, Exercise, and Performance Psychology) practitioners during their applied work. Specifically, these factors were investigated through various demographic lenses such as gender, experience level, and age in order to describe the population. SEPP graduate students (n = 49) and early career professionals (n = 82) were asked to participate in a questionnaire, …


Experiences And Perceptions Of Female Athletic Trainers Working With Male Coaches In Male Sports, Sierra Hobday Jan 2022

Experiences And Perceptions Of Female Athletic Trainers Working With Male Coaches In Male Sports, Sierra Hobday

College of Graduate Studies: Theses & Dissertations

Context: Female athletic trainers are making great strides in a previously male-dominated profession and are also becoming more prevalent in working with male sports teams. Female athletic trainers working within male sports often face gender bias and discrimination which has been found to come from male coaches of these sports. While previous studies have shown male coaches may demonstrate practices of gender bias towards female athletic trainers working in male sports, no studies have focused directly on the male coach and female athletic trainer relationship. Purpose: To examine the experiences and perceptions of female athletic trainers currently working with male …


Coping Self-Efficacy As A Moderator In The Relationship Between Trauma And Disordered Eating, Bethany Owens Raymond Jan 2022

Coping Self-Efficacy As A Moderator In The Relationship Between Trauma And Disordered Eating, Bethany Owens Raymond

College of Graduate Studies: Theses & Dissertations

Disordered eating behaviors are associated with a myriad of detrimental health and mental health consequences (Ackard et al., 2003; Bryla, 2003; Karkkainen et al., 2018; Quick & Byrd-Bredbenner, 2013). Previous research identifies trauma as a risk factor for disordered eating behaviors and eating disorders (Brewerton, 2007). For instance, individuals with eating disorders are more likely to report trauma than individuals with no such history (Lejonclou et al., 2014). However, because not all individuals with a history of trauma exhibit disordered eating, it is important to identify what factors might moderate this relationship. The current study aims to investigate coping-self efficacy …


Proof-Of-Concept: Safety Hazard Identification And Impact Minimization Using 3d Bim And Vr Devices Through The Case-Studies, Sudeep Pangeni Jan 2022

Proof-Of-Concept: Safety Hazard Identification And Impact Minimization Using 3d Bim And Vr Devices Through The Case-Studies, Sudeep Pangeni

College of Graduate Studies: Theses & Dissertations

Construction hazard is a global issue. Despite numerous research studies, safety guidelines and procedures, fatalities and severe injuries still occur on construction job sites. This research has been performed to identify the research gaps and potentially improve worker behavior along the most hazardous tasks during construction execution using 3D Building Information Modeling (BIM) and Virtual Reality (VR) devices. A safety hazards-related questionnaire for civil engineering and construction students, superintendents, safety, and project managers across six different states including the state of Georgia was deployed. The questionnaire was distributed via an online platform to identify and approach the hazards which occur …


Viral Injustice, Brandon L. Garrett, Lee Kovarsky Jan 2022

Viral Injustice, Brandon L. Garrett, Lee Kovarsky

Faculty Scholarship

The COVID-19 pandemic blighted all aspects of American life, but people in jails, prisons, and other detention sites experienced singular harm and neglect. Housing vulnerable detainee populations with elevated medical needs, these facilities were ticking time bombs. They were overcrowded, underfunded, unsanitary, insufficiently ventilated, and failed to meet even minimum health-and-safety standards. Every unit of national and sub-national government failed to prevent detainee communities from becoming pandemic epicenters, and judges were no exception.

This Article takes a comprehensive look at the decisional law growing out of COVID-19 detainee litigation and situates the judicial response as part of a comprehensive institutional …


Cities, Preemption, And The Statutory Second Amendment, Joseph Blocher Jan 2022

Cities, Preemption, And The Statutory Second Amendment, Joseph Blocher

Faculty Scholarship

Although the Second Amendment tends to dominate the discussion about legal limits on gun regulation, nothing has done more to shape the state of urban gun law than state preemption laws, which fully or partially limit cities’ ability to regulate guns at the local level. The goals of this short Essay are to shed light on this “Statutory Second Amendment” and to provide a basic framework for evaluating it.


Dismantling The Wall, Charles Shane Ellison, Anjum Gupta Jan 2022

Dismantling The Wall, Charles Shane Ellison, Anjum Gupta

Faculty Scholarship

Between 2017 and 2021, the Trump Administration waged an unprecedented battle on U.S. asylum structure, procedure, and substantive law. Seeking to alter long-standing legal principles and practices in a host of areas, the former administration’s efforts to demolish asylum protections were systematic and comprehensive. The Immigration Policy Tracking Project cataloged no fewer than ninety-six discrete policy and regulatory changes that the former administration implemented to curtail access to asylum. While some of the administration’s actions, such as the decision to separate children from their parents at the border, were carried out in the open, many other actions were largely hidden …


The Need For Social Support From Law Schools During The Era Of Social Distancing, Michele Okoh, Inès Ndonko Nnoko Jan 2022

The Need For Social Support From Law Schools During The Era Of Social Distancing, Michele Okoh, Inès Ndonko Nnoko

Faculty Scholarship

Law students have been faced with unparalleled stress during the syndemic. They must cope with being students during the COVID-19 pandemic but also must deal with stress related to social and political unrest. This essay recommends that law schools apply social support theory in developing interventions to effectively address the needs of law students now and in the future.

Social support theory focuses on the value and benefits one receives from positive interpersonal relationships. These positive relationships impact both mental and physical health and promote beneficial short and long-term overall health. However, not all supports are the same, and social …


Effectiveness Of Telemedicine In Diabetes Management: A Retrospective Study In An Urban Medically Underserved Population Area (Umupa)., Lisa Ariellah Ward Jan 2022

Effectiveness Of Telemedicine In Diabetes Management: A Retrospective Study In An Urban Medically Underserved Population Area (Umupa)., Lisa Ariellah Ward

College of Graduate Studies: Theses & Dissertations

The purpose of this research is to assess the efficacy of employing telemedicine (TM) technology compared to traditional face-to-face (F2F) visits as an alternative healthcare delivery service for managing diabetes in populations residing in urban medically underserved areas (UMUPA). Researchers investigating public health and healthcare systems fully grasp the enormous challenges encountered by vulnerable populations as a result of healthcare access barriers.1 Prior to the COVID-19 pandemic, F2F visits were most often utilized for healthcare delivery service, which frequently posed barriers for vulnerable populations. When marginalized people, encounter healthcare access barriers, a cascade of events generally occur leading to …


Microvascular Consequences Of Engineered Nanomaterial Inhalation Exposure And Subsequent Reproductive Outcomes, Krista Lee Garner Jan 2022

Microvascular Consequences Of Engineered Nanomaterial Inhalation Exposure And Subsequent Reproductive Outcomes, Krista Lee Garner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nano-titanium dioxide (nano-TiO2) is a commonly utilized engineered nanomaterial found ubiquitously in consumer products. While benefits of ENM utilization in are undeniable, nanoparticle inhalation has been linked to cardiovascular consequences and altered microvascular responses. Given these outcomes, it is important to explore vulnerable timepoints, such as gestation, as robust vascular adaptations are essential for maternofetal health.

The first aim of this dissertation was to assess myogenic responsiveness following maternal nano-TiO2 inhalation. Fetal aortic responses were evaluated on gestational day (GD) 20 to assess how exposure may impact the F1 generation. Myogenic responsiveness within the uterine radial arteries …


Evaluating Effects Of Sediment On Microbial Loading In A Drinking Water Distribution System, Erika Osborne Jan 2022

Evaluating Effects Of Sediment On Microbial Loading In A Drinking Water Distribution System, Erika Osborne

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drinking water distribution systems (DWDS) are critical for protecting public health by ensuring safe water is transported from centralized treatment facilities to consumers. Sediment accumulation in DWDS is a common challenge that water utilities face that may pose some health risks when waterborne pathogens colonize biofilms formed on the sediment surface. Water utilities often establish flushing routines to help mitigate sediment accumulation in their system but the role that sediment plays in contributing to the total microbial loading in the system is unclear. The main objective of this study was to determine if sediment in a DWDS presents a significant …


A Domain Adaptation Approach For Segmenting Cell Instances In Microscopy Data, Matthew R. Keaton Jan 2022

A Domain Adaptation Approach For Segmenting Cell Instances In Microscopy Data, Matthew R. Keaton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Automated cellular instance segmentation is a process that has been utilized for accelerating biological research since before the deep learning era, and recent advancements have produced higher quality results with less effort from the biologist. Most current endeavors focus on completely cutting the researcher out of the picture by generating highly generalized models. However, these models invariably fail when faced with novel data and effectively opt to miss out on the full capabilities of deep learning in pursuit of this goal. In our work, we demonstrate how, with even a minimal amount of annotated data, dominant approaches in this space …


Cytotoxic Effects Of Potential Irrigants For Endodontic Surgery, Kaiying Haggard Jan 2022

Cytotoxic Effects Of Potential Irrigants For Endodontic Surgery, Kaiying Haggard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: The aim of this study is to investigate if hypochlorous acid (Vashe and Endocyn), Ozone, sodium hypochlorite (0.5% NaOCl), chlorhexidine (0.12% CHX), and MTAD can be used as a disinfectant for endodontic surgery without causing bone tissue toxicity by comparing their cytotoxic effects to saline on osteoblasts in vitro.

Methods: Human Fetal Osteoblast Cells (hFOB 1.19, ATCC CRL-11372) were used. The cells viability after 10-minute exposure of Vashe, Endocyn, Ozone, NaOCl (0.5%), CHX (0.12%), MTAD, and saline at concentrations of 10, 30, 60, 90 % volume ratio were measured using CCK8 analysis and the absorbance were measured at 450 …


Food Safety In The Us: Regulation, Liability, And Tracing, Marziyeh Bahalou Horeh Jan 2022

Food Safety In The Us: Regulation, Liability, And Tracing, Marziyeh Bahalou Horeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation addresses three issues related to food safety. First, it examines the economic efficiency of irrigation water quality guidelines of Food Safety Modernization Act. Second, it estimates the value of traceability in the U.S. lettuce supply chain. Third, it uses state-level data and panel regression models to examine the relationship between product liability laws and reported foodborne illnesses in the U.S.

The second chapter develops a theoretical framework and a corresponding empirical analysis to analyze the Food and Drug Administration's irrigation water quality regulatory standard pursuant to the Food Safety Modernization Act. We develop a stochastic, price endogenous partial …


Epithelial Morphogenesis In The Drosophila Egg Chamber Requires Parvin And Ilk, Athina Keramidioti, Evgenia Golegou, Eleni Psarra, Nikolaos Paschalidis, Konstantina Kalodimou, Shinya Yamamoto, Christos Delidakis, Katerina M Vakaloglou, Christos G Zervas Jan 2022

Epithelial Morphogenesis In The Drosophila Egg Chamber Requires Parvin And Ilk, Athina Keramidioti, Evgenia Golegou, Eleni Psarra, Nikolaos Paschalidis, Konstantina Kalodimou, Shinya Yamamoto, Christos Delidakis, Katerina M Vakaloglou, Christos G Zervas

Duncan NRI Faculty and Staff Publications

Integrins are the major family of transmembrane proteins that mediate cell-matrix adhesion and have a critical role in epithelial morphogenesis. Integrin function largely depends on the indirect connection of the integrin cytoplasmic tail to the actin cytoskeleton through an intracellular protein network, the integrin adhesome. What is currently unknown is the role of individual integrin adhesome components in epithelia dynamic reorganization. Drosophila egg chamber consists of the oocyte encircled by a monolayer of somatic follicle epithelial cells that undergo specific cell shape changes. Egg chamber morphogenesis depends on a developmental array of cell-cell and cell-matrix signalling events. Recent elegant work …


Emerging Roles Of Alternative Cleavage And Polyadenylation (Apa) In Human Disease, Prakash Dharmalingam, Rajasekaran Mahalingam, Hari Krishna Yalamanchili, Tingting Weng, Harry Karmouty-Quintana, Ashrith Guha, Rajarajan A Thandavarayan Jan 2022

Emerging Roles Of Alternative Cleavage And Polyadenylation (Apa) In Human Disease, Prakash Dharmalingam, Rajasekaran Mahalingam, Hari Krishna Yalamanchili, Tingting Weng, Harry Karmouty-Quintana, Ashrith Guha, Rajarajan A Thandavarayan

Duncan NRI Faculty and Staff Publications

In the messenger RNA (mRNA) maturation process, the 3'-end of pre-mRNA is cleaved and a poly(A) sequence is added, this is an important determinant of mRNA stability and its cellular functions. More than 60%-70% of human genes have three or more polyadenylation (APA) sites and can be cleaved at different sites, generating mRNA transcripts of varying lengths. This phenomenon is termed as alternative cleavage and polyadenylation (APA) and it plays role in key biological processes like gene regulation, cell proliferation, senescence, and also in various human diseases. Loss of regulatory microRNA binding sites and interactions with RNA-binding proteins leading to …


Stil-Life, Yi Xiong Jan 2022

Stil-Life, Yi Xiong

Graduate Theses, Dissertations, and Problem Reports (ETD)

This written thesis is the supporting documentation for Still-Life, my Master of Fine Arts thesis exhibition. I use handmade ceramic still-life objects to depict my specific memories and experiences about my life before and after the pandemic. Death, hope, time, and emotion are the themes explored in this exhibition.

This installation of ceramic sculptures not only recreates a historical moment in the pandemic but also captures the current times that we live in. It records the artist's life and time during the COVID-19 pandemic. The selection of still-life objects for the exhibition often has special significance on a personal, cultural, …


Elucidating The Proteasomal Regulatory Mechanism Of Proteasome Activator Pa28Γ /Regγ, Taylor Ann Thomas Jan 2022

Elucidating The Proteasomal Regulatory Mechanism Of Proteasome Activator Pa28Γ /Regγ, Taylor Ann Thomas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Virtually all cellular processes are precisely regulated by the proteasome which is the primary enzyme responsible for the degradation of misfolded, damaged, or no longer necessary soluble proteins. To prevent any untimely degradation of these target protein substrates and protect the cell, the proteasome is tightly regulated via adaptor proteins, known as proteasomal regulators. There are many classes of proteasomal regulators each with their own unique structures, functions, and effects on protein degradation through the proteasome. One such class is the 11S family of proteasomal regulators which are also referred to as PA26/28, or REG. The 11S family are ATP-independent …


A Mixed-Methods Protocol To Develop And Validate A Stewardship Maturity Matrix For Human Genomic Data In The Cloud, Vasiliki Rahimzadeh, Ge Peng, Mildred Cho Jan 2022

A Mixed-Methods Protocol To Develop And Validate A Stewardship Maturity Matrix For Human Genomic Data In The Cloud, Vasiliki Rahimzadeh, Ge Peng, Mildred Cho

Center for Medical Ethics and Health Policy Staff Publications

This article describes a mixed-methods protocol to develop and test the implementation of a stewardship maturity matrix (SMM) for repositories which govern access to human genomic data in the cloud. It is anticipated that the cloud will host most human genomic and related health datasets generated as part of publicly funded research in the coming years. However, repository managers lack practical tools for identifying what stewardship outcomes matter most to key stakeholders as well as how to track progress on their stewardship goals over time. In this article we describe a protocol that combines Delphi survey methods with SMM modeling …


Decreased Brain Ventricular Volume In Psychiatric Inpatients With Serotonin Reuptake Inhibitor Treatment, P K Bolin, S N Gosnell, K Brandel-Ankrapp, N Srinivasan, A Castellanos, R Salas Jan 2022

Decreased Brain Ventricular Volume In Psychiatric Inpatients With Serotonin Reuptake Inhibitor Treatment, P K Bolin, S N Gosnell, K Brandel-Ankrapp, N Srinivasan, A Castellanos, R Salas

Staff and Researcher Publications

Background: Brain ventricles have been reported to be enlarged in several neuropsychiatric disorders and in aging. Whether human cerebral ventricular volume can decrease over time with psychiatric treatment is not well-studied. The aim of this study was to examine whether inpatients taking serotonin reuptake inhibitors (SRI) exhibited reductions in cerebral ventricular volume.

Methods: Psychiatric inpatients, diagnosed mainly with depression, substance use, anxiety, and personality disorders, underwent two imaging sessions (Time 1 and Time 2, approximately 4 weeks apart). FreeSurfer was used to quantify volumetric features of the brain, and ANOVA was used to analyze ventricular volume differences between Time 1 …