Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2022

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 75601 - 75630 of 76356

Full-Text Articles in Entire DC Network

Conflict Positioning In Crisis Communication: Impact Of Antecedent Conditions On Negotiation, Pang, A., Glen T. Cameron Jan 2022

Conflict Positioning In Crisis Communication: Impact Of Antecedent Conditions On Negotiation, Pang, A., Glen T. Cameron

Research Collection Lee Kong Chian School Of Business

Organizations need to position themselves favorably in times of crisis. The conflict positioning conceptualization offers a framework for organizations to do so by integrating insights of crisis communication with negotiation through the following steps. First, understanding the factors that will affect an organization's ability to handle the crisis. Second, based on the influence of these factors, examine the stance the organization will adopt. Third, examine the strategies the organization will embrace. Four, the strategies adopted will impact the conflict property it aims to resolve which will in turn influence the negotiation approach and the relationship dynamics between the organization and …


Effect Of Agricultural Insurance Program On Income Loss Reduction: A Comparative Study Of Upland And Lowland Farmers In Japan And The Philippines, Armand Christopher C. Rola Jan 2022

Effect Of Agricultural Insurance Program On Income Loss Reduction: A Comparative Study Of Upland And Lowland Farmers In Japan And The Philippines, Armand Christopher C. Rola

Journal of Public Affairs and Development

This paper aims to inquire how agricultural insurance can be an effective and efficient coping mechanism to prevent the poorest in remote rural areas of East Asia and the Pacific from falling into the poverty trap when faced with natural disasters. Field research was conducted to examine upland and lowland farmers’ experiences with agricultural insurance and program implementation by insurance providers in Japan and the Philippines. Secondary data such as online articles, journals, books, news and annual reports, and online websites of government insurance providers in the Philippines and Japan were collected. Primary data were analyzed using descriptive and cost …


Intellectual Capital To Support Goat Farming Profitability In A Rural Area Of Banjarnegara Regency, Indonesia, Mochamad Sugiarto, Yusmi Nur Wakhidati, Siwi Gayatri, John Enorio M. Perez Jan 2022

Intellectual Capital To Support Goat Farming Profitability In A Rural Area Of Banjarnegara Regency, Indonesia, Mochamad Sugiarto, Yusmi Nur Wakhidati, Siwi Gayatri, John Enorio M. Perez

Journal of Public Affairs and Development

Goat farming in Banjarnegara Regency, Indonesia has become a driver of the rural economy.  Banjarnegara Regency, Indonesia has become a driver of the rural economy. Banjarnegara is a mountainous area which is divided into three agroecological zones, namely highland, middle land, and lowland. The research was conducted to (1) identify the levels of goat farmers’ intellectual capital and goat farming profitability; and (2) analyze the relationship between goat farmers’ intellectual capital and goat farming profitability. A multistage sampling method was conducted to collect data from 180 goat farmers. The research on goat farmers’ intellectual capital was conducted using interviews and …


Climate Change And Sustainability In Asean Countries, David K. Ding, Sarah E. Beh Jan 2022

Climate Change And Sustainability In Asean Countries, David K. Ding, Sarah E. Beh

Research Collection Lee Kong Chian School Of Business

The ASEAN region is one of the most susceptible regions to climate change, with three of its countries—Myanmar, the Philippines, and Thailand—among those that have suffered the greatest fatalities and economic losses because of climate-related disasters. This paper reveals that the ASEAN’s environmental performance is sorely lagging other regions despite evidence of its cohesive and comprehensive efforts to mitigate emissions and build up adaptive capacity to climate-related disasters. Within the ASEAN, there exist gaps in environmental performance between each country. This suggests that increased cooperation between individual ASEAN countries is pertinent for the region to collectively combat climate change. In …


Exploring How Online Responses Change In Response To Debunking Messages About Covid-19 On Whatsapp, Xingyu Ken Chen, Jin-Cheon Na, Luke Kien-Weng Tan, Mark Chong, Murphy Choy Jan 2022

Exploring How Online Responses Change In Response To Debunking Messages About Covid-19 On Whatsapp, Xingyu Ken Chen, Jin-Cheon Na, Luke Kien-Weng Tan, Mark Chong, Murphy Choy

Research Collection Lee Kong Chian School Of Business

Purpose: The COVID-19 pandemic has spurred a concurrent outbreak of false information online. Debunking false information about a health crisis is critical as misinformation can trigger protests or panic, which necessitates a better understanding of it. This exploratory study examined the effects of debunking messages on a COVID-19-related public chat on WhatsApp in Singapore. Design/methodology/approach: To understand the effects of debunking messages about COVID-19 on WhatsApp conversations, the following was studied. The relationship between source credibility (i.e. characteristics of a communicator that affect the receiver's acceptance of the message) of different debunking message types and their effects on the length …


Killing The Cat? A Review Of Curiosity At Work, Filip Lievens, Spencer H. Harrison, Patrick Mussel, Jordan A. Litman Jan 2022

Killing The Cat? A Review Of Curiosity At Work, Filip Lievens, Spencer H. Harrison, Patrick Mussel, Jordan A. Litman

Research Collection Lee Kong Chian School Of Business

This paper focuses on the emergent importance of curiosity at work for individuals and organizations by reviewing management research on curiosity at work. We start by leveraging prior reviews on early and contemporary foundations of the curiosity construct in the larger psychological literature, with a focus on definitional clarity, dimensionality, and differences with other constructs in its nomological network. Next, we review different streams of management research on curiosity at work (i.e., broad generative and nongenerative effects, curiosity as a catalyst for personal action, curiosity as a catalyst for interpersonal action, curiosity as a catalyst for leadership, curiosity as an …


My First Time Ungrading: Approach Used And Reflections, Heather J. Leslie Phd Jan 2022

My First Time Ungrading: Approach Used And Reflections, Heather J. Leslie Phd

Learning Design Center: Staff Scholarship

A few months ago, I began devouring information about ungrading with a fervent appetite. I started with the book Ungrading: Why Rating Students Undermines Learning (and What To Do Instead), edited by Susan Blum, and listened to just about every podcast where she was interviewed about this topic. I then read other books she recommended, like Wad-Ja-Get: The Grading Game in American Education by Howard Kirschenbaum and Punished By Rewards: The Trouble with Gold Stars, Incentive Plans, A’s, and Praise by Alfie Kohn. Recently, I have become much more dialed in to the ungrading movement by reading articles from Teachers …


Left Ventricular Assist Device Support And Longitudinal Sleeve Gastrectomy Combined With Diet In Bridge To Heart Transplant, Mandy Ng, Beverly Rodgers, Saadiya Rehman, Sriram S Nathan, Kulvinder S Bajwa, Shinil K Shah, Bindu H Akkanti, Marwan F Jumean, Sachin Kumar, Jennifer L Dressel, Rajko Radovancevic, Melissa M Felinski, Biswajit Kar, Igor D Gregoric Jan 2022

Left Ventricular Assist Device Support And Longitudinal Sleeve Gastrectomy Combined With Diet In Bridge To Heart Transplant, Mandy Ng, Beverly Rodgers, Saadiya Rehman, Sriram S Nathan, Kulvinder S Bajwa, Shinil K Shah, Bindu H Akkanti, Marwan F Jumean, Sachin Kumar, Jennifer L Dressel, Rajko Radovancevic, Melissa M Felinski, Biswajit Kar, Igor D Gregoric

The Texas Heart Institute Journal

Combining left ventricular assist device (LVAD) implantation and longitudinal sleeve gastrectomy may enable patients with morbid obesity to lose enough weight for heart transplant eligibility. In a retrospective study, we evaluated long-term outcomes of patients with body mass indexes ≥35 who underwent LVAD implantation and longitudinal sleeve gastrectomy during the same hospitalization (from January 2013 through July 2018) and then adhered to a dietary protocol. We included 22 patients (mean age, 49.9 ± 12.5 yr; mean preoperative body mass index, 43.3 ± 6.2). Eighteen months after gastrectomy, all 22 patients were alive, and 16 (73%) achieved a body mass index …


A Survey Of Tele-Critical Care State And Needs In 2019 And 2020 Conducted Among The Members Of The Society Of Critical Care Medicine, Donna Lee Armaignac Jan 2022

A Survey Of Tele-Critical Care State And Needs In 2019 And 2020 Conducted Among The Members Of The Society Of Critical Care Medicine, Donna Lee Armaignac

All Publications

Abstract: The study’s objective was to assess facilitators and barriers of Tele-Critical Care (TCC) perceived by SCCM members. By utilizing a survey distributed to SCCM members, a cross-sectional study was developed to analyze survey results from December 2019 and July 2020. SCCM members responded to the survey (n = 15,502) with a 1.9% response rate for the first distribution and a 2.54% response rate for the second survey (n = 9985). Participants (n = 286 and n = 254) were almost equally distributed between non-users, providers, users, and potential users of TCC services. The care delivery models for TCC were …


Updates On Hydroxychloroquine In Prevention And Treatment Of Covid-19, Heather Johnson Jan 2022

Updates On Hydroxychloroquine In Prevention And Treatment Of Covid-19, Heather Johnson

All Publications

No abstract provided.


Development And Initial Validation Of An Acculturation Measure For Arab Expatriates In Qatar Using Mixed Methods, Sara Ali Ahmed Zikri Jan 2022

Development And Initial Validation Of An Acculturation Measure For Arab Expatriates In Qatar Using Mixed Methods, Sara Ali Ahmed Zikri

Electronic Theses and Dissertations

Prior research on acculturation has predominantly focused on specific immigrant and ethnic groups in the United States, Europe, and Asia, and there is a lack of publicly available scales that measure acculturation among expatriates in countries of the Gulf Cooperation Council. The purpose of this study was to use a mixed methods research design to develop a theoretical framework of acculturation for white-collar Arab expatriates in Qatar as well as a culturally appropriate self-report acculturation measure. The acculturation stories and experiences of white-collar Arab expatriates in Qatar were qualitatively explored and analyzed, and their findings were used to construct an …


Inequalities In Prevalence Of Birth By Caesarean Section In Ghana From 1998-2014, Joshua Okyere, Henry Ofori Duah, Abdul-Aziz Seidu, Bright Opoku Ahinkorah, Eugene Budu Jan 2022

Inequalities In Prevalence Of Birth By Caesarean Section In Ghana From 1998-2014, Joshua Okyere, Henry Ofori Duah, Abdul-Aziz Seidu, Bright Opoku Ahinkorah, Eugene Budu

College of Nursing Faculty Research and Publications

Background

Caesarean section (CS) is an intervention to reduce maternal and perinatal mortality, for complicated pregnancy and labour. We analysed trends in the prevalence of birth by CS in Ghana from 1998 to 2014.

Methods

Using the World Health Organization’s (WHO) Health Equity Assessment Toolkit (HEAT) software, data from the 1998-2014 Ghana Demographic and Health Surveys (GDHS) were analysed with respect of inequality in birth by CS. First, we disaggregated birth by CS by four equity stratifiers: wealth index, education, residence, and region. Second, we measured inequality through simple unweighted measures (Difference (D) and Ratio (R)) and complex weighted measures …


Improving Healthcare Provider Knowledge Of Hospice And Palliative Medicine, Ashleigh T. Flora Jan 2022

Improving Healthcare Provider Knowledge Of Hospice And Palliative Medicine, Ashleigh T. Flora

DNP Projects

By addressing the diseases symptoms directly, palliative care improves patients feel and can participate in their life by providing indispensable holistic health management and support for patients and families. Hospice is the focused service of palliative care, provided by specially trained healthcare professionals. Evidence suggests that patients are poorly educated on chronic illnesses, providers are failing to have end of life discussions with patients, and providers are poorly educated as to services available to patients at end of life. This quality improvement project was designed to assess provider knowledge of hospice and palliative care utilization. Convenience sampling was used to …


Evaluating Provider Knowledge On The Impact Of Vitamin D Deficiency In Chronic Health Conditions, Shelly Alamry Jan 2022

Evaluating Provider Knowledge On The Impact Of Vitamin D Deficiency In Chronic Health Conditions, Shelly Alamry

DNP Projects

Vitamin D deficiency affects nearly one billion individuals globally. It is an essential vitamin to maintain bone health as well as the overall health of the body. Recent research reveals the significance of vitamin D deficiency in chronic health conditions like osteoporosis, depression, breast cancer, dementia, and viral infections like COVID-19. The Doctor of Nursing Practice (DNP) project aimed to evaluate if education regarding vitamin D deficiency was effective in improving provider knowledge, increases practice confidence levels, and results in self-reported practice changes. An educational session and two questionnaires were administered to healthcare providers in the state of Mississippi. Before …


2021-2022 Annual Security And Fire Report - Sayre Campus, Southwestern Oklahoma State University Jan 2022

2021-2022 Annual Security And Fire Report - Sayre Campus, Southwestern Oklahoma State University

ANNUAL SECURITY & FIRE REPORTS

This is the 2021-2022 Annual Security and Fire Report of the Sayre Campus by Southwestern Oklahoma State University.


A Textual Analysis Of Logograms In Chinese Ipo Roadshows: How Agreement Between Investors And Management Relates To Pricing And Performance, James C. Brau, James Cicon, Stephen R. Owen Jan 2022

A Textual Analysis Of Logograms In Chinese Ipo Roadshows: How Agreement Between Investors And Management Relates To Pricing And Performance, James C. Brau, James Cicon, Stephen R. Owen

Faculty Publications

We analyze the interaction between management and investors during Chinese IPO roadshows through Jaccard Similarity analysis of written Chinese logograms. We provide evidence that when agreement is high, investor optimism increases, leading to relatively large first-day underpricing. We further show that high agreement biases investors to systematically overestimate IPO prospects leading to poor long-run abnormal performance. Jaccard Similarity is different from current content analysis methodologies because it is language and culture agnostic, requiring no a priori construction of thematic dictionaries. Elimination of such dictionaries removes the danger that the researcher has imposed predispositions upon the study.


Richard Evans Schultes, James P. Smith Jr Jan 2022

Richard Evans Schultes, James P. Smith Jr

Botanical Studies

No abstract provided.


An Annotated List Of The Poisonous And Injurious Vascular Plants Of The United States, James P. Smith Jr Jan 2022

An Annotated List Of The Poisonous And Injurious Vascular Plants Of The United States, James P. Smith Jr

Botanical Studies

No abstract provided.


Sustainability And Justice: Challenges And Opportunities For An Open Stem Education, Carrie Diaz Eaton, Kaitlin Bonner, Karen Cangialosi, Bryan Dewsbury, Maggie Diamond-Stanic, Jason Douma, Michelle Smith, Robin Taylor, Jeremy Wojdak, Krystie Wilfong Jan 2022

Sustainability And Justice: Challenges And Opportunities For An Open Stem Education, Carrie Diaz Eaton, Kaitlin Bonner, Karen Cangialosi, Bryan Dewsbury, Maggie Diamond-Stanic, Jason Douma, Michelle Smith, Robin Taylor, Jeremy Wojdak, Krystie Wilfong

All Faculty Scholarship

Open educational resources, or OER, are teaching materials that reside in the public do-main and are available under an open license. While the creation of high-quality materials and cyberinfrastructure to share these resources is important, OER are much more than static resource repositories. Vibrant OER communities function as collaboration hubs and often include librarians, instructional technologists, instructors, education researchers, funders, open-source software developers, and college administrators. Together, these in-dividuals work as a community to respond to changes in the education landscape, support student learning impacts both in terms of cost savings and student retention, and solve issues related to broadly …


Open Science Via Hubzero: Exploring Five Science Gateways Supporting And Growing Their Open Science Communities, Sandra Gesing, Claire Stirm, Gerhard Klimeck, Lynn Zentner, Su Wang, Braulio Misael Villegas Martinez, Carrie Diaz Eaton, Sam Donovan, Lan Zhao, Carol Song, Et Al. Jan 2022

Open Science Via Hubzero: Exploring Five Science Gateways Supporting And Growing Their Open Science Communities, Sandra Gesing, Claire Stirm, Gerhard Klimeck, Lynn Zentner, Su Wang, Braulio Misael Villegas Martinez, Carrie Diaz Eaton, Sam Donovan, Lan Zhao, Carol Song, Et Al.

All Faculty Scholarship

The research landscape applying computational methods has become increasingly interdisciplinary and complex regarding the research computing ecosystem with novel hardware, software, data, and lab instruments. Reproducibility of research results, the usability of tools, and sharing of methods are all crucial for timely collaboration for research and teaching. HUBzero is a widely used science gateway framework designed to support online communities with efficient sharing and publication processes. The paper discusses the growth of communities for the five science gateways nanoHUB, MyGeoHub, QUBEShub & SCORE, CUE4CHNG, and HubICL using the HUBzero Platform to foster open science and tackling education with a diverse …


Linking Tree Cover Change To Historical Management Practices In Urban Parks, Sabine Nix, Lara A. Roman, Marc Healy, John Rogan, Hamil Pearsall Jan 2022

Linking Tree Cover Change To Historical Management Practices In Urban Parks, Sabine Nix, Lara A. Roman, Marc Healy, John Rogan, Hamil Pearsall

Geography

Context: Urban tree canopy (UTC) in parks is shaped by complex interactions between social and ecological processes over decades. To understand UTC change in parks, it is critical to identify and characterize the unique set of social processes that drive long-term change. Objectives: We sought to uncover the feedbacks between social processes and long-term UTC changes in parks of a post-industrial city that experienced substantial population loss and park disinvestment. Methods: Our mixed-methods approach involved quantifying spatiotemporal UTC changes and connecting those changes to historical management practices for three parks in Philadelphia, PA (US). We delineated UTC using aerial imagery …


Using The Mulligan Mobilization With Movement And Fibular Repositioning To Treat High School Patients With A Grade One Lateral Ankle Sprain, Alexander Zettlemoyer, Rich Patterson, Russell Baker, Alan Nasypany Jan 2022

Using The Mulligan Mobilization With Movement And Fibular Repositioning To Treat High School Patients With A Grade One Lateral Ankle Sprain, Alexander Zettlemoyer, Rich Patterson, Russell Baker, Alan Nasypany

Clinical Practice in Athletic Training

Ankle injuries are common among high school athletics with the highest incidence rates in boys and girls basketball and boys football. Novel treatment paradigms like the Mulligan Mobilization with Movement (MWM) in conjunction with fibular repositioning tape have shown promising results in reducing pain, disability, and time lost due to lateral ankle sprains (LAS). However, research focusing on Mulligan treatment strategies and ankle swelling following a LAS is limited. Therefore, the purpose of this case series was to evaluate the combined effects of the MWM and fibular repositioning taping on swelling, function, and pain in high school patients with an …


Clinical Implications Of Telemedicine For Surgical Care: An Evidence-To-Practice Review, Adam M. Hollien, Mary Catherine Avey, Zachary K. Winkelmann Jan 2022

Clinical Implications Of Telemedicine For Surgical Care: An Evidence-To-Practice Review, Adam M. Hollien, Mary Catherine Avey, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Telemedicine is a newer concept in medicine that utilizes technological devices to provide care to patients. In a society already greatly advanced with technology, telemedicine is the new frontier in healthcare. Implementing telemedicine into current practices will benefit both the patient and the provider. The technology utilized with telemedicine has demonstrated promise by decreasing patient travel time, decreasing lost time from work, increasing patient interactions, and increasing interprofessional collaboration. The cost of implementation is minimal compared to the cost savings that will be accrued from utilizing this technology. There are many specialty areas in healthcare where telemedicine can be implemented …


Improving Ankle Range Of Motion With The Use Of Instrument Assisted Soft Tissue Mobilization: A Validation Case Study, Sarah Jakubek, Elena Robinson, Annette D. Monk Jan 2022

Improving Ankle Range Of Motion With The Use Of Instrument Assisted Soft Tissue Mobilization: A Validation Case Study, Sarah Jakubek, Elena Robinson, Annette D. Monk

Clinical Practice in Athletic Training

The purpose of this case validation study was to examine the effects of Instrument-Assisted Soft Tissue Mobilization (IASTM) on the ankle. The patient population consisted of nine participants (2 females, 7 males, age = 16± 2 years) from a suburban high school in Illinois. Each patient completed an IASTM treatment program, incorporating the Graston Technique (GT). The program was completed over a three-week period with 2 sessions occurring each week, for a total of 6 sessions. Data collection of ankle dorsiflexion range of motion (DFROM) occurred after the completion of the GT. This was assessed by performing the weight-bearing lunge …


Safety Of Blood Flow Restriction Training For Musculoskeletal Disorders: An Evidence-To-Practice Review, Breanna Ferguson, Erica Schulman, Matthew Zimmerman, Zachary K. Winkelmann Jan 2022

Safety Of Blood Flow Restriction Training For Musculoskeletal Disorders: An Evidence-To-Practice Review, Breanna Ferguson, Erica Schulman, Matthew Zimmerman, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Blood flow restriction training (BFRT) is low-level resistance training while partially occluding proximal blood flow. It is well documented that this style of training leads to increased muscle size as well as strength. It is theorized that these size and strength gains are due in part to the decreased oxygen environment. This results in increased muscular stress without the need for increased external load making this style of resistance training ideal for individuals who have restrictions due to musculoskeletal disorders. The guiding systematic review examined the safety of BFRT when used as a therapeutic intervention for patients with a variety …


Creating And Implementing A Covid-19 Prevention And Response Program In The Performing Arts: A Clinician Expertise Commentary, David Tomchuk, Kyle Schneider, Jacklyn Bascomb-Harrison Jan 2022

Creating And Implementing A Covid-19 Prevention And Response Program In The Performing Arts: A Clinician Expertise Commentary, David Tomchuk, Kyle Schneider, Jacklyn Bascomb-Harrison

Clinical Practice in Athletic Training

No abstract provided.


Exertional Heat Stroke In A Male High School Runner With Disordered Eating: A Disablement Model Case Study, Brittni G. Hoover, Rebecca M. Hirschhorn, Allison B. Smith, Amy F. Hand Jan 2022

Exertional Heat Stroke In A Male High School Runner With Disordered Eating: A Disablement Model Case Study, Brittni G. Hoover, Rebecca M. Hirschhorn, Allison B. Smith, Amy F. Hand

Clinical Practice in Athletic Training

A 16-year-old male high school cross country athlete collapsed at the end of an afternoon 5K cross country meet. The patient was unable to stand, and after outwardly displaying confusion and agitation, his coaches sought assistance from the athletic trainers (ATs). The patient consumed one cup of water and a granola bar on the day of the meet. The ambient air temperature was 90°F with 69% humidity. Differential diagnoses included exertional heat stroke (EHS), exertional heat exhaustion, exertional collapse associated with sickle cell trait, heat syncope, dehydration, malnutrition, and hypoglycemia. Approximately 20 minutes passed between activation of the emergency action …


The Increased Push For Implementing Caate Diversity, Equity, And Inclusion Standards In The Southwest Athletic Trainers’ Association (Swata), Luzita Vela, Meredith Decker, Ramonica Scott, Brandon Warner, Shaketha Pierce Jan 2022

The Increased Push For Implementing Caate Diversity, Equity, And Inclusion Standards In The Southwest Athletic Trainers’ Association (Swata), Luzita Vela, Meredith Decker, Ramonica Scott, Brandon Warner, Shaketha Pierce

Clinical Practice in Athletic Training

No abstract provided.


Characteristics Of Sickle Cell Trait Policies And Procedures At Ncaa Division I Institutions, H Parker, B J. Warner, D M. Gallegos, S A. Cage Jan 2022

Characteristics Of Sickle Cell Trait Policies And Procedures At Ncaa Division I Institutions, H Parker, B J. Warner, D M. Gallegos, S A. Cage

Clinical Practice in Athletic Training

Context: In 2010, the National Collegiate Athletic Association (NCAA) introduced a proposal addressing sickle cell trait screening. This proposal later became a policy that required student-athletes in their first year of eligibility to provide their institution with accurate information regarding their sickle cell trait status. There does not appear to be a recent study published that has examined the sickle cell trait policies and procedures currently being used by NCAA Division I institutions. The purpose of this study was to describe the characteristics of sickle cell trait policies and procedures at NCAA Division I institutions. Methods: We used a web-based …


Raman Spectroscopy Reveals Phenotype Switches In Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman Jan 2022

Raman Spectroscopy Reveals Phenotype Switches In Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman

Biomedical Engineering Faculty Publications and Presentations

The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling metastatic progression of cancer. Here, we report a label-free optical strategy using Raman spectroscopy and machine learning to identify distinct metastatic phenotypes observed in tumors formed by isogenic murine breast cancer cell lines of progressively increasing metastatic propensities. Methods: We employed the 4T1 isogenic panel of murine breast cancer cells to grow tumors of varying metastatic potential and acquired label-free spectra using a fiber probe-based portable Raman spectroscopy system. We used MCR-ALS and random forests classifiers to identify putative spectral …