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2022

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Performance Of Indirect Immunofluorescence Test And Immunoblot Tests In The Evaluation Of Antinuclear And Antimitochondrial Antibodies, Ömer Öztürk, Selay Demi̇rci̇ Dos Santos Duarte, Hati̇ce Yasemi̇n Balaban, Hali̇s Şi̇mşek, Burçi̇n Şener Jan 2022

Performance Of Indirect Immunofluorescence Test And Immunoblot Tests In The Evaluation Of Antinuclear And Antimitochondrial Antibodies, Ömer Öztürk, Selay Demi̇rci̇ Dos Santos Duarte, Hati̇ce Yasemi̇n Balaban, Hali̇s Şi̇mşek, Burçi̇n Şener

Turkish Journal of Medical Sciences

Background/aim: Antinuclear antibodies (ANA) and antimitochondrial antibodies (AMA) have essential markers for the diagnosis of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). These autoantibodies are detecting different laboratory methods. In this study, we studied the diagnostic performance of used methods in detecting ANA and AMA. Materials and methods: The autoantibody profiles of patients with AIH and PBC groups were analyzed with the indirect immunofluorescence test (IIF) and liver-specific antigens containing immunoblot test (IB). Results: There were 45 (87%) women in the study group and 8 (53%) women in the control group. The mean age of the patients was 50.5 …

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Prospective Analysis Of Intoxicated Patients Developing Shock And/Or Organ Failure, Faysal Teki̇n, Ayça Açikalin Akpinar, Ömer Taşkin, Ufuk Akday, Nezi̇hat Rana Di̇şel, Emre Karakoç Jan 2022

Prospective Analysis Of Intoxicated Patients Developing Shock And/Or Organ Failure, Faysal Teki̇n, Ayça Açikalin Akpinar, Ömer Taşkin, Ufuk Akday, Nezi̇hat Rana Di̇şel, Emre Karakoç

Turkish Journal of Medical Sciences

Background/aim: Data on intoxication patients with shock and acute organ failure is valuable for the prediction of the tailored scale prognosis of the patients in the emergency department. Materials and methods: Our study was designed prospectively as a cross-sectional and observational over the course of four years. The patients over 18 years of age were included and the epidemiological data related to development of shock and acute organ failure, the treatments, and the outcome were recorded. The organic phosphate severity score was also calculated for all patients. Results: A total of 89 patients with shock and/or acute organ failure 72 …

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The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle Jan 2022

The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle

Turkish Journal of Medical Sciences

Background/aim: Sjögren?s syndrome is a systemic, autoimmune disease and can affect many organs and systems. In this study, we aimed to evaluate the respiratory manifestations, and the association between interstitial lung disease (ILD) and disease activity in primary SS (pSS) patients. Materials and methods: The study design was retrospective cross-sectional, and 151 patients followed up with a diagnosis of pSS between 2004 and 2019 were included in the study. Demographic and clinical data, laboratory results, chest radiographs and thorax computed tomography (CT) results were obtained from patient files and hospital imaging system. Thorax CT was requested from all patients with …

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Outcome Of Solid And Cavitary Pulmonary Nodules In Rheumatoid Arthritis Patients? Case Series, Aysun Aksoy, Derya Kocakaya, Yasemi̇n Yalçinkaya, Emi̇ne Bozkurtlar, Sai̇t Karakurt, Semi̇ha Emel Eryüksel, Güzi̇de Nevsun İnanç Jan 2022

Outcome Of Solid And Cavitary Pulmonary Nodules In Rheumatoid Arthritis Patients? Case Series, Aysun Aksoy, Derya Kocakaya, Yasemi̇n Yalçinkaya, Emi̇ne Bozkurtlar, Sai̇t Karakurt, Semi̇ha Emel Eryüksel, Güzi̇de Nevsun İnanç

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two …

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Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari Jan 2022

Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari

Turkish Journal of Medical Sciences

Background/aim: The revised Leeds Disability Questionnaire (RLDQ) is a unique assessment tool for patients with ankylosing spondylitis (AS); its comprehensive structure includes posture and neck flexibility parameters. The aim of the study was to determine the psychometric properties of the Turkish RLDQ in patients with AS. Materials and methods: A total of 100 AS patients were enrolled in the study. In the first evaluation, patients filled out the Dougados Functional Index (DFI) and Bath Ankylosing Spondylitis Functional Index (BASFI), Stanford Health Assessment Questionnaire (HAQ) in addition to RLDQ. Then, patients were refilled the revised RLDQ in the second assessment. Results: …

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The Effects Of Κ-Casein, Ss-Lactoglobulin, Prolactin And Dgat1 Polymorphisms On Milkyields In Turkish Holstein Cows, Emi̇ne Şahi̇n Semerci̇, Murat Soner Balcioğlu Jan 2022

The Effects Of Κ-Casein, Ss-Lactoglobulin, Prolactin And Dgat1 Polymorphisms On Milkyields In Turkish Holstein Cows, Emi̇ne Şahi̇n Semerci̇, Murat Soner Balcioğlu

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the effects of κ-casein, β-lactoglobulin, prolactin, and DGAT1 (diacylglycerol acyltransferase1) gene polymorphisms on milk yields in Holstein cows raised in Antalya province, Turkey. A total of 517 cows were genotyped by the PCR-RFLP method to detect κ-casein/HinfI, β-lactoglobulin/HaeIII, prolactin/RsaI, and DGAT1/Cfr1 polymorphisms. In the study, two types of alleles were identified as A and B for κ-casein, ß-lactoglobulin, and prolactin loci, while K and A alleles were detected for DGAT1 locus. The frequencies of A and B allele were calculated as 0.8279 and 0.1721 for κ-casein, 0.4662 and 0.5338 for ß-lactoglobulin, 0.8762 …

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Gene Expression And Doppler Flowmetry Of The Reproductive Tract In Nelore (Bos Indicus)Cows Synchronized With Estradiol And Equine Chorionic Gonadotrophin, Itamara Gomes De França, Nancyleni Pinto Cahves Bezerra, Alcina Vieira Carvalho Neta, Larissa Sarmento Santos, Diego Luiz Ds Santos Ribeiro, Jose Ribamar S Torres Junior Jan 2022

Gene Expression And Doppler Flowmetry Of The Reproductive Tract In Nelore (Bos Indicus)Cows Synchronized With Estradiol And Equine Chorionic Gonadotrophin, Itamara Gomes De França, Nancyleni Pinto Cahves Bezerra, Alcina Vieira Carvalho Neta, Larissa Sarmento Santos, Diego Luiz Ds Santos Ribeiro, Jose Ribamar S Torres Junior

Turkish Journal of Veterinary & Animal Sciences

Forty Nelore cows were submitted to timed artificial insemination (TAI) protocol and randomly assigned to groups according to estradiol (E2) ester (cypionate or benzoate, i.e. EC or EB) and equine chorionic gonadotrophin treatment (eCG or No-eCG) in a factorial 2x2 design. On a random day of the estrous cycle (Day 0), cows received a P4 intravaginal device plus 2 mg im injection of EB. At the time of P4 device removal (Day 8), cows were treated with 0.150 mg im of D-cloprostenol (PGF) and randomly divided to receive or not 400 UI im of eCG, as well as randomly assigned …

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Interaction Effects Of Age And Body Weight Losses During Moulting On The Performance Ofcommercial Laying Hens, Mian Mubashar Saleem, Jibran Hussain, Usman Elahi, Ehsaan Ullah Khan, Muhammad Usman, Syed Ghulam Mohayudin Hashmi, Sohail Ahmad Jan 2022

Interaction Effects Of Age And Body Weight Losses During Moulting On The Performance Ofcommercial Laying Hens, Mian Mubashar Saleem, Jibran Hussain, Usman Elahi, Ehsaan Ullah Khan, Muhammad Usman, Syed Ghulam Mohayudin Hashmi, Sohail Ahmad

Turkish Journal of Veterinary & Animal Sciences

This study evaluated the interaction effects of different age groups and body weight losses during moulting on the productive performance, egg quality, and immune response of commercial laying hens. In total 324 Lohmann Selected Leghorn Lite laying hens of 80 and 108 weeks old were studied. A completely randomized experimental design in factorial arrangement, with 6 treatments of 6 replicates with 9 hens each, was applied. Treatments consisted of 2 production cycles (80 and 108 weeks) and three body weight losses during moulting (20%, 25%, and 30%). Productive performance (body weight, feed intake, egg weight, production percent, egg mass, feed …

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Determination Of Plant-Specific Retrotransposons In Chicken, Levent Mercan, Ci̇hat Erdem Bülbül, Fati̇h Bi̇lgi̇, Sevgi̇ Marakli Jan 2022

Determination Of Plant-Specific Retrotransposons In Chicken, Levent Mercan, Ci̇hat Erdem Bülbül, Fati̇h Bi̇lgi̇, Sevgi̇ Marakli

Turkish Journal of Veterinary & Animal Sciences

Mobile genetic elements are also known as transposons, comprising a significant proportion of plant and animal genomes. Retrotransposons, a class of transposons, move copy and paste mechanism and, therefore, cause genome obesity. Moreover, the transferability of retrotransposons within and between different kingdoms has provided valuable information for evolutionary relationships in addition to detailed knowledge about genomes. We identified barley-specific retrotransposons (Nikita and Sukkula) and determined polymorphism ratios of these retrotransposons in a chicken genome for the first time to gain new insights for retrotransposons found in different genomes. Transposon sequences belonging to chicken and barley genomes were also investigated to …

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The Effects Of Polymorphisms In The Cx3cr1 Gene On The Development Of Canine Hipdysplasia, Sertaç Atalay, Süleyman Kök Jan 2022

The Effects Of Polymorphisms In The Cx3cr1 Gene On The Development Of Canine Hipdysplasia, Sertaç Atalay, Süleyman Kök

Turkish Journal of Veterinary & Animal Sciences

Hip dysplasia, caused by both environmental and genetic components, is a common disorder characterized by hip instability in humans and dogs. Unfortunately, the genetic mechanisms that cause the disease in both have not been fully determined. The aim of this study was polymorphisms in the exon 2 and 3' UTR regions of the CX3CR1 gene were determined and their effects on the development of Canine Hip Dysplasia (CHD) in three dog breeds (German Shepherd, Belgian Malinois, Labrador Retriever). For this purpose, a case -control study was designed with 172 dogs in Dog Breeding and Training Center (DBTC) in Turkey. Each …

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Cryoprotective Effect Of Vaccenic Acid Supplemented In Bull Semen Extender, Fati̇h Avdatek, Umut Taşdemi̇r, Muhammed Enes İnanç, Deni̇z Yeni̇, Mehmet Fuat Gülhan, Şükrü Güngör, Ruhi̇ Türkmen, Pürhan Barbaros Tuncer Jan 2022

Cryoprotective Effect Of Vaccenic Acid Supplemented In Bull Semen Extender, Fati̇h Avdatek, Umut Taşdemi̇r, Muhammed Enes İnanç, Deni̇z Yeni̇, Mehmet Fuat Gülhan, Şükrü Güngör, Ruhi̇ Türkmen, Pürhan Barbaros Tuncer

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate whether vaccenic acid (VA) added to TRIS semen extender has an effect on freezing bull semen. The semen was collected at intervals of three days through an artificial vagina then pooled. The pooled ejaculates were divided into five components as the control (C; no supplement) and VA (25, 50, 100, and 200 μg / mL) groups then extended with the TRIS-based medium. The samples were left in a cold air cabinet for cooling process (4 °C), then they were equilibrated for 4 h. Afterward, the samples in the groups were frozen by …

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Molecular Characterization Of Bacillus Anthracis Isolates Recovered From Nomic Andnonnomic Hosts, Doğan Akça, Fati̇h Büyük, Emre Karakaya, Mustafa Reha Coşkun, Eli̇f Çeli̇k, Mi̇tat Şahi̇n, Özgür Çelebi̇, Sali̇h Otlu, Ali̇ye Gülmez Sağlam, Eray Büyük, Seda Durhan, İzzet Burçi̇n Saticioğlu, Seçi̇l Abay, Tuba Kayman, Fuat Aydin Jan 2022

Molecular Characterization Of Bacillus Anthracis Isolates Recovered From Nomic Andnonnomic Hosts, Doğan Akça, Fati̇h Büyük, Emre Karakaya, Mustafa Reha Coşkun, Eli̇f Çeli̇k, Mi̇tat Şahi̇n, Özgür Çelebi̇, Sali̇h Otlu, Ali̇ye Gülmez Sağlam, Eray Büyük, Seda Durhan, İzzet Burçi̇n Saticioğlu, Seçi̇l Abay, Tuba Kayman, Fuat Aydin

Turkish Journal of Veterinary & Animal Sciences

Anthrax, which is primarily a disease of herbivores, is known to infect many animal species. In order to break the cycle of anthrax infection, it is important to identify the potential hosts or reservoirs of its causative agent. Therefore, this study aimed to characterize Bacillus anthracis isolates recovered from a variety of hosts and environments during anthrax sporadic in the Kars and Kayseri regions of Turkey. For this purpose, a total of 23 B. anthracis field isolates obtained from human, cattle, sheep, dog, horse, puma, soil, and fodder were used. In addition, the Sterne vaccine strain was included. All B. …

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The Apoptotic And Proliferative Effects Of Tulathromycin And Gamithromycin On Bovinetracheal Epithelial Cell Culture, Yaşar Şahi̇n, Ebru Yildirim, Begüm Yurdakök Di̇kmen, Mustafa Türk Jan 2022

The Apoptotic And Proliferative Effects Of Tulathromycin And Gamithromycin On Bovinetracheal Epithelial Cell Culture, Yaşar Şahi̇n, Ebru Yildirim, Begüm Yurdakök Di̇kmen, Mustafa Türk

Turkish Journal of Veterinary & Animal Sciences

Gamithromycin and tulathromycin are commonly used in the treatment of bovine respiratory bacterial diseases. The current work was undertaken to establish the apoptotic, necrotic, and cytotoxic effects of these antibiotics in the target animal. Cells with apoptosis and necrosis were determined by dual staining method, cytotoxic effects were determined by MTT assay, cell proliferative effects were examined by XCelligence real-time cell analysis system (RTCA-SP). The comparison between gamithromycin and tulathromycin concentrations on tracheal cells in terms of % cell viability was found to be significantly different. While the cell viability percentage of gamithromycin was higher at 150 μg/mL, 180 μg/mL, …

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Effect Of Age, Stocking Density, Genotype, And Cage Tier On Feather Score Of Layer Pure Lines, Selami̇ Tok, Ahmet Şekeroğlu, Mustafa Duman, Brian Tainika Jan 2022

Effect Of Age, Stocking Density, Genotype, And Cage Tier On Feather Score Of Layer Pure Lines, Selami̇ Tok, Ahmet Şekeroğlu, Mustafa Duman, Brian Tainika

Turkish Journal of Veterinary & Animal Sciences

The objective of the study was to investigate the effect of genotype, age, stocking density, and cage tier on the feather score of egg-laying pure lines. The trial was carried out with five white (BLACK, BLUE, MARON, BROWN, and D229) and six brown (RIR1, RIR2, BAR1, BAR2, COL, and LINE54) eggshell lines as classified by the Ankara poultry research institute. In the experiment, 162 chicks were randomly selected from each of the 11 lines; thus, a total of 1782 chicks (810 and 972 white and brown layer pure lines, respectively). At 17 weeks of age, pullets were chosen at random …

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A Game Theoretic Approach To Design Mating Programs For Livestock, Ebru Ergüneş Berki̇n, Hasan Önder, Özgür Hakan Aydoğmuş Jan 2022

A Game Theoretic Approach To Design Mating Programs For Livestock, Ebru Ergüneş Berki̇n, Hasan Önder, Özgür Hakan Aydoğmuş

Turkish Journal of Veterinary & Animal Sciences

In this study, we proposed a new game theoretic method to design a mating program. The index and game theoretic methods were applied with calculated breeding values using pedigree on two different data sets whose economic traits consist of negative (milk yield and fat percentage) and positive (birth and weaning weight) genetic correlated data. For the negative genetic correlated data set, even if total expected benefits were equal for two methods, mating programs were changed, and the coefficient of variation obtained using the game theoretic method was smaller than that of the index method. This result showed that the expected …

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Effects Of Centrifugation And Washing Of Freeze-Thawed Blood On Isolated Dna Characteristics, Mevlüt Arslan Jan 2022

Effects Of Centrifugation And Washing Of Freeze-Thawed Blood On Isolated Dna Characteristics, Mevlüt Arslan

Turkish Journal of Veterinary & Animal Sciences

DNA isolations from the whole blood are commonly performed to obtain DNA for molecular research and diagnostics. Generally, blood samples are taken into anticoagulant tubes and stored in deep freezers until DNA isolation. In fresh blood, pretreatments or leukocytes preparations can be performed and suggested for advanced DNA isolation. However, similar applications in freeze-thawed blood (FTB) have not been shown yet. In the study, centrifugation and washing of FTB were applied as pretreatment before DNA isolations, and their effects on isolated DNA characteristics including DNA integrity, quality, quantity, mitochondrial (mt), and nuclear (n) DNA levels were investigated. Microscopic and flow …

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Can Surfactants Affect Mortality And Morbidity In Term Infants With Respiratory Failure?, Senem Alkan Özdemi̇r, Özlem Yilman, Şebnem Çalkavur, Tüli̇n Gökmen Yildirim Jan 2022

Can Surfactants Affect Mortality And Morbidity In Term Infants With Respiratory Failure?, Senem Alkan Özdemi̇r, Özlem Yilman, Şebnem Çalkavur, Tüli̇n Gökmen Yildirim

Turkish Journal of Medical Sciences

Background/aim: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. Materials and methods: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were …

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Estimation Of The Factors Affecting Lactation Milk Yield Of Holstein Cattle By The Adaptiveneuro-Fuzzy Inference System, Aycan Mutlu Yağanoğlu Jan 2022

Estimation Of The Factors Affecting Lactation Milk Yield Of Holstein Cattle By The Adaptiveneuro-Fuzzy Inference System, Aycan Mutlu Yağanoğlu

Turkish Journal of Veterinary & Animal Sciences

The aim of this study is to estimate lactation milk yield of Holstein cattle using first calving age, lactation period, and service period with (ANFIS) adaptive neuro-fuzzy inference system. The input variables for the system in the study were first calving age, lactation period, and service period. The output variable from the system was lactation milk yield. Predicted values obtained from the ANFIS were compared with the observed values. Twenty-seven rule functions are used to obtain the best model and 1000 epochs are used to estimate the accuracy of the training and testing error. The relations between the output and …

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Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman Jan 2022

Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman

Turkish Journal of Medical Sciences

Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods: This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of …

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The State Of Work In Athletic Training: A Conversation, K. Ellis F. Mair, Lindsey E. Eberman Jan 2022

The State Of Work In Athletic Training: A Conversation, K. Ellis F. Mair, Lindsey E. Eberman

Clinical Practice in Athletic Training

No abstract provided.

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Body Tempering And Its Effect On Ankle Dorsiflexion And Power, Neal Ori, Justin Goins, Jay Patel, Robbie Ingle Jan 2022

Body Tempering And Its Effect On Ankle Dorsiflexion And Power, Neal Ori, Justin Goins, Jay Patel, Robbie Ingle

Clinical Practice in Athletic Training

Body Tempering (BT) is a newer myofascial release (MFR) technique that is used by athletes and healthcare professionals. The effects of BT are stated to be similar to foam rolling (FR) and other MFR techniques, but there is minimal research assessing the effects of BT on power and range of motion (ROM). The purpose of this study was to determine the effect of BT on ankle dorsiflexion ROM and power, as well as to compare the effects of BT to traditional FR. Twenty college-aged participants (10 males-10 females) were tested before and after intervention on three measurements of the broad …

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Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli Jan 2022

Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli

Turkish Journal of Medical Sciences

Background/aim: Systemic sclerosis (SSc) is a chronic systemic disease characterized by vascular damage, autoimmunity, and fibrosis in the skin and internal organs. In this study, we tried to determine the causes of severe infection in patients with SSc and to reveal the factors associated with severe infection. Materials and methods: We retrospectively examined 214 SSc patients between January 2010 and August 2020. Forty-seven patients with at least one severe infection and 167 patients without severe infection were compared. Results: A total of 76 episodes of severe infections were detected in 47 (22%) patients. Common infections included pneumonia, infected digital ulcer, …

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Concussion Profiles: Moving Beyond The Graded Symptom Scale, Tamara Valovich Mcleod, Brian Vesci Jan 2022

Concussion Profiles: Moving Beyond The Graded Symptom Scale, Tamara Valovich Mcleod, Brian Vesci

Clinical Practice in Athletic Training

No abstract provided.

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Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci Jan 2022

Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci

Turkish Journal of Medical Sciences

Background/aim: Intravesical BCG treatment fails inexplicably in 30%-45% of patients for high-grade nonmuscle-invasive bladder cancer (NMIBC). We aimed to investigate the role of PD-1/PD-L1 interaction on BCG failure of high-grade NMIBC and to identify biomarkers for predicting BCG responsive cases. Materials and methods: Thirty BCG responsive and 29 nonresponsive NMIBCs were included in the study. Expressions of PDL1(SP-263), MSH2, MSH6, PMS2, and MLH1 were evaluated on pre- and post-BCG transurethral resection (TUR-B) specimens by immunohistochemistry. PD-L1(SP-263) expression was categorised as negative/low, high. DNA mismatch repair protein (MMR) expressions were classified as 'reduced' if ≤30% of nuclei stained, 'preserved' if >30% …

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Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara Jan 2022

Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara

Turkish Journal of Medical Sciences

Background/aim: The level of nitric oxide (NO) is important to protect the heart from ischemic damage in acute coronary syndrome (ACS) patients. S-nitrosothiol (SNO) is a molecule that represents the main form of NO storage in the vascular structure. In addition, dynamic thiol/disulfide homeostasis (TDH) is known to play an important role in maintaining the oxidant-antioxidant balance. In this study, our aim is to evaluate the oxidative/nitrosative stress status according to SNO level and TDH in patients with ACS. Materials and methods: The study included 124 patients who were admitted to the emergency service and 124 consecutive individuals who applied …

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The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut Jan 2022

The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut

Turkish Journal of Medical Sciences

Background/aim: Needle phobia occurs in more than half of diabetic patients due to the pain caused by frequent insulin injections. Therefore, this study evaluated the effect of topically administered lavender aromatherapy on the pain of insulin injections in diabetic patients. Materials and methods: In this double-blind randomized controlled and experimental study, patients who met the study criteria were divided into three groups; topical lavender oil (n = 60), placebo (n = 60), and control (n = 60) groups. The data were collected using the "Patient Information Form", the "Follow-up Form", the "Verbal Category Scale (VCS)", and the "Visual Analogue Scale …

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Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu Jan 2022

Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu

Turkish Journal of Medical Sciences

Background/aim: Nicotine acts as an agonist of nicotinic acetylcholine receptors (nAChR). These receptors belong to a superfamily of ligand-gated ion channels. We previously demonstrated that nicotine increased electrical field stimulation (EFS)-induced contractile or relaxation responses, possibly by facilitating neurotransmitter release from nerve terminals in various rabbit tissues. Studies have shown that there is an interaction between the endocannabinoid and nicotinic systems. This study aimed to investigate the interaction between nicotine and the endocannabinoid system in the rabbit urine bladder and also investigate the enhancing effect of nicotine on EFS-induced contractile responses in rabbit isolated bladder smooth muscle and its interaction …

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Etiological, Clinical, And Laboratory Evaluation Of Congenital Hypothyroidism And Determination Of Levothyroxine (Lt4) Dose At Treatment Interruption In Differentiating Permanent Vs. Transient Patients, İsmai̇l Dündar, Mehmet Aki̇f Büyükavci, Nurdan Çi̇ftci̇ Jan 2022

Etiological, Clinical, And Laboratory Evaluation Of Congenital Hypothyroidism And Determination Of Levothyroxine (Lt4) Dose At Treatment Interruption In Differentiating Permanent Vs. Transient Patients, İsmai̇l Dündar, Mehmet Aki̇f Büyükavci, Nurdan Çi̇ftci̇

Turkish Journal of Medical Sciences

Background/aim: Congenital hypothyroidism (CH) is the most common cause of preventable but irreversible mental retardation in children, although the risk has been widely abolished by national neonatal screening programs. The aim of this study was to determine, (a) the cause of CH, (b) the etiological cause of persistent CH and (c) to investigate the role of laboratory and clinical data in predicting persistent and transient CH. Materials and methods: Patients diagnosed with CH, who started L-thyroxine treatment and were followed up for at least three years were included. Patient data were reviewed retrospectively. Serum thyroid hormones were measured four weeks …

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Management Of Recurrent Hemoptysis: A Single-Center Experience, Seda Tural Önür, Sedat Altin, Fatma Tokgöz Akyil, Kaan Kara, Si̇nem Nedi̇me Sökücü, Cengi̇z Özdemi̇r, Mehmet Aki̇f Özgül, Muzaffer Meti̇n, Levent Cansever, Aysun Ölçmen, Nuri̇ Özgür Kiliçkesmez Jan 2022

Management Of Recurrent Hemoptysis: A Single-Center Experience, Seda Tural Önür, Sedat Altin, Fatma Tokgöz Akyil, Kaan Kara, Si̇nem Nedi̇me Sökücü, Cengi̇z Özdemi̇r, Mehmet Aki̇f Özgül, Muzaffer Meti̇n, Levent Cansever, Aysun Ölçmen, Nuri̇ Özgür Kiliçkesmez

Turkish Journal of Medical Sciences

Background/aim: A successful planning methodology for patients with hemoptysis promises overall improvement in patient care. Conducted in a reference center for chest diseases, the present study aims to analyze characteristics and predictors of interventional methods in patients with recurrent hemoptysis. Materials and methods: The present study is a single-center, retrospective observational study. Between 2015 and 2018, 5973 patients with follow-up data until 2021 requiring more than one hospitalization due to recurrent hemoptysis were investigated. Patient characteristics, the amount of hemoptysis, baseline admission parameters, interventional procedures of bronchial artery embolization (BAE), fiberoptic bronchoscopy, rigid bronchoscopy, and surgical resections applied were analyzed …

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Extremely High Erythrocyte Sedimentation Rate Revisited In Rheumatic Diseases: A Singlecenter Experience, Zehra Özsoy, Emre Bi̇lgi̇n, Melek Seren Aksun, İmdat Eroğlu, Umut Kalyoncu Jan 2022

Extremely High Erythrocyte Sedimentation Rate Revisited In Rheumatic Diseases: A Singlecenter Experience, Zehra Özsoy, Emre Bi̇lgi̇n, Melek Seren Aksun, İmdat Eroğlu, Umut Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: The objectives were to define the distribution of rheumatic diseases in patients with erythrocyte sedimentation rate (ESR) ≥ 100 mm/h and to find variables that can differentiate main study groups from others. Materials and methods: Charts of patients admitted with ESR ≥ 100 mm/h between 2015 and 2020 were reviewed. Patients were divided into four diagnostic groups based on etiology: infection (without a rheumatic diagnosis), oncologic (without a rheumatic diagnosis), rheumatic, and no definitive diagnosis. Patients with the rheumatic diagnosis were divided into three main study groups: those who had been recently diagnosed with a rheumatic disease, those who …

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