Digital Commons Network^™

Growth Of Condition-Related Knowledge Among Youth With Spina Bifida: Associations With Neurocognitive Functioning And Self-Management Skills, Olivia Emery Clark

Master's Theses

Spina bifida (SB) is a congenital birth defect that may involve physical, medical, and neuropsychological complications due to central nervous system malformation (Copp et al., 2015). Ambulation problems, bladder and bowel dysfunction, and hydrocephalus require daily medical management tasks, including catheterization, bowel program management, and skin checks to avoid secondary complications. While self-management skills are typically gained during adolescence, executive dysfunction in SB may complicate gains (Dennis et al., 2006; Greenley, 2010). Indeed, evidence in other chronic conditions suggests that adolescent executive dysfunction is linked to poorer medical self-management. Condition-related knowledge has been identified as an important basis of medical …

A Study In The Effectivenss Of Factual Versus Emotional Interventions In Reducing Ambivalent Sexism In Hiring Decisions, Molly Jane Driscoll

Master's Theses

Ambivalent sexism – divided into the categories of benevolent sexism (BS) and hostile sexism (HS) – is imbedded in many parts of the workplace. This study aims to explore if ambivalent sexism influences hiring decisions and, if so, what can be done about it. After completing a series of surveys, participants were asked to read about an agentic female candidate who applied for a male-dominated position. Afterwards, participants went through either a factual or emotional intervention before reevaluating their decision. Major results showed that only the emotional intervention increased the likelihood of the candidate being hired but it is not …

Phenotypic Analysis Of Murine Gut Associated Lymphocytes, Madison Flood

Master's Theses

γδ T cells are important in the role of immune homeostasis, especially in relation to the gut. It has been shown that there is a higher proportion of γδ T cells in the intestines than in circulation. With this knowledge, our lab focused on understanding the mechanisms of these cells, specifically regarding immune tolerance. In our preliminary research, we identified a subset of γδ T cells that express Foxp3, a transcription factor essential for the functioning of regulatory T cells, in the neonatal (5 day old) intestine. We hypothesized that these Foxp3+ γδ T cells have immunosuppressive functions upon exposure …

Examining The Bidirectional Relations Between Psychological Functioning And Academic Outcomes Among College Students, Maya Hareli

Master's Theses

Emerging adulthood is a developmental period associated with a variety of transitions and changes, including rising rates of mental health concerns (Arnett, 2004, 2006; Center for Collegiate Mental Health, 2020). The literature has established that both psychological and academic functioning are critical components of students’ lives, as mental health has been shown to interfere with students’ grades, graduation rates, and postgraduate employment (Hartley, 2010; Mojtabai et al., 2015), while poor achievement is associated with mental health challenges in college and beyond (Bruffaerts et al., 2018; Respondek et al., 2017). Additionally, women and men have been shown to experience these areas …

Bisacodyl Limits Chikungunya Virus In Vitro And Is Broadly Antiviral, Natalie June Lomascolo

Master's Theses

Identifying novel antivirals requires significant time and resource investment, and the continuous threat of viruses to human health necessitates commitment to antiviral identification and development. Developing antivirals requires years of research and validation, and recent outbreaks have highlighted the need for preparedness in counteracting pandemics. One way to facilitate development is to repurpose molecules already used clinically. By screening such compounds, we can accelerate antiviral development. Here, we screened compounds from the National Institutes of Health’s Developmental Therapeutic Program for activity against chikungunya virus, an alphavirus that is responsible for a significant outbreak in the Americas in 2013. Using this …

Influences Of Latino Caregivers’ Input And Acculturation On Children’S Bilingual Development: A Speech Sample Analysis, Jordan Sierra Perry

Master's Theses

Interactions with caregivers are important for children’s development. In particular, the language input that young dual language learners (DLLs) receive from their primary caregivers affects their cultural knowledge and their bilingual language outcomes. However, relatively little research has been conducted to investigate the cultural contexts that influence Latino caregivers’ bilingual language use at home, including their acculturation level. Thus, the present study examined the relation between caregivers’ acculturation and their children’s bilingual (Spanish and English) language use, and whether this relation varied as a function of caregivers’ bilingual language use. Parent-report measures of bilingual language use, in addition to video …

Investigating The Role Of Nagc Reveals It To Be A Global Regulator, Natasha Peterson

Master's Theses

Bacterial colonization of host surfaces can result in symbiotic or pathogenic associations.As bacteria becomes more resistant to antibiotics, pathogenic bacterial colonization poses an increasing risk to human health. Symbiotic associations that have beneficial outcomes for both the host and the microbe can serve as models to investigate how bacterial processes affect colonization of host surfaces. The symbiotic relationship between the Gram-negative, bioluminescent bacterium Vibrio fischeri and the Hawaiian bobtail squid is one such model (E. V. Stabb & Visick, 2013). The study of this exclusive relationship has developed in a way where in vitro phenotypes can predict the ability of …

Positive Affect Facilitates Reduction In Depression Symptoms During A Mobile Mindfulness-Based Intervention, Andrew Rauch

Master's Theses

Depression negatively impacts the lives of many, and the rates are continuing to rapidly increase. Identifying patterns of modifiable affective psychological mechanisms that contribute to reducing depression symptoms is critical to improve the effectiveness of wellbeing interventions for individuals with depressive disorders. Depression has been characterized by valanced patterns of low positive affect and high negative affect, yet the extent to which these relative patterns of affectivity change in response to intervention remains less clear. The present study evaluated affective patterns in college students (n = 127) with elevated depression symptoms who participated in a randomized controlled trial (RCT) of …

The Role Of Identification In Black Individuals' Goals To Challenge Racism Through Confrontation And Collective Action, Efrata Sasahulih

Master's Theses

Anti-Black racism continues to harm Black individuals in the United States and throughout the world (e.g., police brutality, medical racism: Hoffman, Trawalter, Axt, & Oliver, 2016; Smiley & Fakunle, 2016; Stuber, Meyer, & Link, 2008). Psychological research has investigated the roots of prejudice and strategies to mitigate its negative consequences, including confrontation and collective action. However, research in this area has largely focused on ways that these strategies pose additional risk for targets of prejudice. This research determined if Black people who endorse individual-benefiting or group-benefiting goals following an instance of anti-Black racism use confrontation and collective action, respectively, to …

Delayed Testosterone Treatment In A Rodent Model Of Repeat Mild Traumatic Brain Injury Attenuates Mechanisms Of Cellular Death In The Vestibular Nucleus, Michael Volyanyuk

Master's Theses

A common complaint after repetitive mild traumatic brain injury (rmTBI) is vestibular dysfunction, which can become persistent and decrease quality of life. Delayed testosterone treatment has been shown to reduce vestibular impairment and improve neuronal survival in the vestibular nucleus following rmTBI; however, the long-term molecular pathways associated with rmTBI and testosterone treatment remain widely unexplored. We utilized a 5-hit closed-head rodent rmTBI model and administered testosterone 35 days after injury (DPI). The vestibular nuclei were removed and prepared for RT-qPCR and western blotting. Gene expression and protein levels were elevated for markers of oxidative stress (NADPH oxidase 4) and …

Calcium-Mediated Induction Of Vibrio Fischeri Es114 Biofilms, Katia Elizabeth Semenchuk

Master's Theses

Vibrio fischeri bacteria form biofilms that facilitate symbiotic colonization of the Hawaiian bobtail squid, Euprymna scolopes. These host-associated biofilms require production of the SYP polysaccharide. However, it has been difficult to observe robust biofilm formation in vitro in a laboratory setting using wild-type strain ES114; instead, most work investigating syp-dependent biofilm formation has relied on genetically altered strains. Guided by recent findings that increasing calcium induces c-di-GMP (Tischler et al., 2021), a molecule known in other systems to promote biofilm formation, the question was posed as to whether high levels of calcium alone could promote syp-dependent biofilm formation by ES114. …

Knowledge, Experiences And Perceptions Of Abagusii Community Of Kisii County, Kenya On The Health Consequences Of Female Genital Mutilation (Fgm), Roselyter Riang’A, Moses Mutiso

Population Health, East Africa

Background: Health education is among the prominent forms of interventions that are used to advocate for eradication of the practice of FGM. However, little is known on affected communities’ actual experiences, knowledge and perceptions on these health education messages hence need for this study.

Objective: To understand Abagusii people’s knowledge, experiences and perceptions on the health consequences of FGM.

Methods: Data was collected from Abagusii community of Kisii County in Kenya using interview schedules, focus group discussions, key informants and document analysis. The collected data were qualitatively and quantitatively analysed using SPSS and MAXQDA programs

Results: …

Design And Synthesis Of Curcumin Analogs For Anticancer Activity And Discovery Of Novel Hit Molecules Targeting Cxcr4., Maryam Sadat Hosseini Zare

Dissertations (2016-Present)

Curcumin as a natural compound is made of various components including protein, carbohydrate, and curcuminoid. Curcuminoid is made of curcumin, desmethoxycurcumin and bis desmethoxycurcumin. Curcumin is used for the treatment of cancer and inflammatory disorders, but it has some therapeutic problems like poor bioavailability, poor efficacy, and chemical instability. To overcome these problems, the objective of this study is (1) synthesis of pyrazole curcumin analogs, (2) synthesis of triazole curcumin analogs, and (3) in-vitro study of the anticancer activity of these curcumin analogs on head & neck, breast, pancreatic and glioblastoma cancer cells. During this part of my Ph.D. project, …

Physical Activity And Sedentary Behaviour Among Children And Adolescents With Intellectual Disabilities During The Covid-19 Lockdown In China, Y. Q. Yuan, J. N. Ding, N. Bi, M. J. Wang, S. C. Zhou, X. L. Wang, S. H. Zhang, Y. Liu, G. Roswal

Research, Publications & Creative Work

Background: In the wake of the COVID-19 pandemic, preliminary research has reported a significant decline in physical activity (PA) and an increase in sedentary behaviour (SB) among typically developed children and adolescents. Limited research has looked at the current situation of PA and SB during this pandemic among children and adolescents with intellectual disabilities (ID). This study investigated the situations about PA and SB among school-aged children and adolescents with ID on China’s mainland during the COVID-19 outbreak.

Methods: In total, 837 parents of children and adolescents (ages 6–18 years) with ID from 15 special education schools of Shandong Province …

Twitter: More Than Tweets For Undergraduate Student Researchers, Nathan S. Reyna, Christin Pruett, Mike Morrison, Jennifer Fowler, Sumali Pandey, Lori Hensley

Research, Publications & Creative Work

A vital component of a CURE is feeling a sense of community. While our students often present to each other at the end of the semester, we have struggled with having them interact with a wider audience. A few students may present class results at a regional or national meeting; however, feasibility limits this opportunity to only a handful of students. Twitter has been used as a tool to disseminate scientific findings (1, 2). As a result of COVID-19, scientific societies have used Twitter to provide snapshots of research to be presented at their virtual meetings using “Twitter Posters” (Michael …

Biofilms On Plastic Litter: Community Composition And Activity And The Effects On Ecosystem Processes, Raul F. Lazcano

Master's Theses

The rapid increase of plastic production and disposal has resulted in plastic pollution becoming a global problem. In aquatic ecosystems, plastic litter is a substrate for biofilms, but little research has simultaneously assessed the effects of plastic litter on biofilm activity, community composition, and ecosystem processes. Our objectives were to: (1) measure biofilm activity and community composition on plastic litter relative to a natural surface in an urban river and (2) assess the impact of microplastic pollution on ecosystem metabolism and N2 flux in an oligotrophic lake. For objective (1) we incubated three common plastics with distinct physical and chemical …

The World Health Organization, The Trump Administration, American Public Opinion, And China: A Principal-Agent Problem, Megan Patrice Larson

Master's Theses

Why did the United States perceive the World Health Organization as ineffective during the COVID-19 pandemic? To answer this question, this research delves into current principal-agent model literature to reproduce mechanisms present by the WHO and the United States. Current research fails to explain the WHO's effectiveness. By borrowing from realist theory and political psychology and analyzing various declarations made by the United States, this analysis found preliminary evidence that the idea of WHO's ineffectiveness was primarily shaped by the Trump Administration and American public opinion. Moreover, because of the disinformation and misinformation spread by the Trump Administration, the WHO …

Dna Methylation Patterns Of Line-1 Elements Specific To Hc21p In Cancer Cells, Dametria Jetters

Master's Theses

Long Interspersed Nuclear Elements (LINEs) are retrotransposons. They function by making a cDNA copy, reverse-transcribing it into DNA and reinserting itself back into the genome; thereby, increasing its copy number. Sequencing of the human genome revealed that LINEs (L1) are underrepresented on the short arm of human chromosome 21 (HC21), but it is enriched in full-length copies. A number of previous studies have investigated the DNA methylation patterns of L1s in cancer cells, but these studies are typically done in euchromatic regions. The heterochromatic short arm of HC21 is primarily composed of heterochromatin. However these regions can be targeted for …

Unveiling Bacterial Hitchhikers In The Urobiome, Genevieve Baddoo

Master's Theses

Microbial communities of bacteria, viruses, and fungi form complex interactions in nature. However, our understanding of these communities is limited to those that can be cultured in the lab. Enhanced culture methods have enabled the isolation of numerous fastidious species from urinary tract, definitively proving that the urinary tract of asymptomatic individuals is not sterile. In working with these isolates, our group has observed several instances in which a “purified” isolate actually harbors more than one species. We refer to these additional members as bacterial hitchhikers, a term previously used to describe similar occurrences in soil communities. I hypothesized that …

Modeling The Impact Of Peer Mentorship To Support First-Year Student Well-Being, Sarah Broner

Master's Theses

The transition to college is characterized by instability in a variety of life domains, with some students experiencing sharp declines in well-being across the first year of college (Conley et al., 2014). Well-established in the literature is the link between this life transition and increased rates of mental illness, including depression, anxiety, stress, and relationship problems (Auerbach et al., 2018). The adjustment to higher education can be particularly difficult for underserved students (Carter et al., 2013; Kalsner & Pistole, 2003), who may not have access to the same types of knowledge, resources, and privileges as their White counterparts on campus. …

The Impact Of Perceived Discrimination And Stigma Consciousness On Connectedness, Trust, And Satisfaction In Healthcare Domains During The Covid-19 Pandemic, Devon Richardson

Master's Theses

This study will assess the relations between perceived experiences of discrimination within healthcare settings and connectedness, trust, and satisfaction with services in healthcare domains among African Americans. It will also examine if the Covid-19 pandemic has exacerbated this relationship. I predict that African Americans in the COVID-19 discrimination condition (versus the control condition) will report lower connectedness and trust with healthcare workers and lower satisfaction with healthcare services. I also predict that stigma consciousness will moderate this effect. For African Americans reporting lower levels of stigma consciousness, I expect there will be a negative relation between perceiving discrimination and connectedness, …

Psychological Symptoms, Visceral Pain Sensitivity, And Observations Of Parent Pain Behavior Are Related To Somatic Symptoms In Premenarchal Adolescents, Genevieve Roth

Master's Theses

Somatic symptoms are a risk factor for the development of chronic pelvic pain in women. The present study characterized somatic symptoms and their relations with psychological, pain sensitivity, and parental factors in a community sample of premenarchal adolescents, which marks an initial step in advancing the identification of potential modifiable factors related to menstrual pain and chronic pain development. Pain sensitivity (visceral and bodily factors) and psychological symptoms (anxiety and stress) were predicted to be related to somatic symptoms (e.g, widespread bodily discomfort) in premenarchal adolescents. Additionally, adolescents’ observation of parent pain behavior was expected to be specifically associated with …

A Tale Of Five Case Studies: Reflections On Piloting A Case-Based, Problem-Based Learning Curriculum In English Composition, Katie Strand, Rachel Wishkoski, Alex J. Sundt, Deanna Allred

Library Faculty & Staff Publications

Part of a volume about storytelling in academic library contexts, this chapter reflects on the use of case studies in a sequenced information literacy curriculum in ENGL 2010 (Intermediate Writing: Research Writing in a Persuasive Mode). In highly interactive sessions across the semester, students collaboratively researched a case study topic and co-created artifacts that reflected their shared journey as researchers. The chapter is organized into the following sections, consistent with the other chapters in the book: classroom vignette, storytelling goal, audience, delivery, theory, cultural considerations, and practical examples. Readers will learn about things to consider when using case-based problem-based learning …

Affirmed Or Delegated? Finding Inherent Tribal Civil Power To Issue Protection Orders Against All Persons In Light Of Spurr V. Pope, Kelly Gaines Stoner, Cherokee Ancestry, Lauren Van Schilfgaarde, Cochiti Pueblo

Tribal Law Journal

Federal courts have wreaked havoc on tribal jurisdiction by injecting incertitude over their most basic authority, including the authority to issue and enforce civil protection orders. This jurisdictional incertitude causes not just legal disruption, but also further compromises the safety of Native people who are disproportionately victimized, especially by gender-based forms of violence. While Congress has been slow to remedy the onslaught of judicial limitations on tribal jurisdiction, Congress has at least remedied tribal authority to issue and enforce protection orders in 18 U.S.C. § 2265(e). However, even in this remedy, jurisdictional incertitude remains.

A Toolkit For The Usability Evaluation Of Digital Health Technologies, Inocencio Daniel Maramba

School of Nursing and Midwifery

Introduction: NHS digital applications are often assessed against the NHS Digital Technology Assessment Criteria (DTAC). However, Small to Medium Enterprise (SME) developers often find DTAC itself ‘heavy going’. One criterion of DTAC is usability and SME developers need guidance on how to meet this criterion. My PhD is a four-part study to develop such guidance. Methods: (i) a scoping review of the methods of usability testing, (ii) development of a novel way of employing a usability scale, dividing it into discrete chunks to prevent “questionnaire fatigue”, (iii) development of a toolkit, (iv) application of the toolkit with SMEs. Results: (i) …

Highlights From The 7th Oncological Pathology Conference 'Pathological Anatomy In The Context Of The National Cancer Law: An Overview Of The Latin American Experience', 15, 22 And 23 July 2022, Trujillo, Peru, Caddie Laberiano-Fernández, Joan Moreno Luján, Bruno De Carvalho Dornelas, Magali Franco Benites, Patricia Gutiérrez Quispe, Valeria Aguilar Vásquez, Andric Guerrero Espinoza, Elsa Guerra Guerra, Gabriela Gil-Arroyo Álvarez, Juan Astigueta-Pérez, Maria Teresa Garcia De Dávila, Sandro Casavilca Zambrano, Tatiana Vidaurre Rojas, Alejandro Mariños, Emmanuel S González, Rossana Lazcano, Ricardo R Lastra, Isabel Alvarado-Cabrero, Henry Guerra Miller, Ricardo H Bardales, Milagros Abad-Licham

Faculty, Staff and Student Publications

The seventh session of the Oncological Pathology Conference (JoPaO) entitled 'Pathological Anatomy in the context of the National Cancer Law: An overview of the Latin American experience', was held virtually on July 15, 22 and 23. Peru was the headquarters for this event, where 17 national and international professors of high academic standing participated. They interacted in a multidisciplinary context through talks with national panellists and the general public. The recent promulgation of the 'National Cancer Law' fosters the development of discussion forums to analyse the national realities and uphold continuous learning about experiences in other Latin American countries with …

Contemporary Evidence On Colorectal Liver Metastases Ablation: Toward A Paradigm Shift In Locoregional Treatment, Yuan-Mao Lin, Reto Bale, Kristy K Brock, Bruno C Odisio

Faculty, Staff and Student Publications

Image-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent application of computer-assisted ablation planning, guidance, and intra-procedural response assessment has improved percutaneous ablation outcomes. In addition, the evolving understanding of tumor molecular profiling has brought to light several …

Serglycin Is Involved In Tgf-Β Induced Epithelial-Mesenchymal Transition And Is Highly Expressed By Immune Cells In Breast Cancer Tissue, Marta Tellez-Gabriel, Xavier Tekpli, Trine M Reine, Beate Hegge, Stephanie R Nielsen, Meng Chen, Line Moi, Lisa Svartdal Normann, Lill-Tove R Busund, George A Calin, Gunhild M Mælandsmo, Maria Perander, Achilleas D Theocharis, Svein O Kolset, Erik Knutsen

Faculty, Staff and Student Publications

Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of cancer cells. Here, we show that serglycin expression is upregulated in transforming growth factor beta (TGF-β) induced epithelial-mesenchymal transition (EMT). Functional studies provide evidence that serglycin plays an important role in the regulation of the transition between the epithelial and mesenchymal phenotypes, …

Pathogenic Tau Accelerates Aging-Associated Activation Of Transposable Elements In The Mouse Central Nervous System, Paulino Ramirez, Gabrielle Zuniga, Wenyan Sun, Adrian Beckmann, Elizabeth Ochoa, Sarah L Devos, Bradley Hyman, Gabriel Chiu, Ethan R Roy, Wei Cao, Miranda Orr, Virginie Buggia-Prevot, William J Ray, Bess Frost

Faculty, Staff and Student Publications

Transposable elements comprise almost half of the mammalian genome. A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation is neurotoxic. Recent studies have identified links between pathogenic forms of tau, a protein that accumulates in Alzheimer's disease and related "tauopathies," and transposable element-induced neurotoxicity. Starting with transcriptomic analyses, we find that age- and tau-induced transposable element activation occurs in the mouse brain. Among transposable elements that are activated at the RNA level in the context of brain aging and tauopathy, we find that the endogenous retrovirus (ERV) class …

Research Career Intentions Among Non-Native English-Speaking Graduate And Postdoctoral Trainees In Stem-Results From Cross-Sectional And Longitudinal Studies, Hwa Young Lee, Shine Chang, Cheryl B Anderson, Erin K Dahlstrom, Carrie Cameron

Faculty, Staff and Student Publications

International graduate trainees, many of whom are non-native English-speaking (L2) trainees, comprise more than half of graduate-level trainees in STEM, but little is known regarding factors that influence their career intentions, especially those that foster their growth as scientists to achieve their full potential in research. Thus, the purpose of our studies was to examine the relationship between L2 status and contextual factors that help shape the learning experiences and plans for research-focused careers. Study 1 collected cross-sectional survey data from doctoral and postdoctoral trainees (N=510) from research institutes in the Texas Medical Center in Houston. We examined which factors …