Digital Commons Network^™

Nemvaleukin Alfa Monotherapy In Patients With Advanced Melanoma And Renal Cell Carcinoma: Results From The Phase 1/2 Non-Randomized Artistry-1 Trial, Emiliano Calvo, Valentina Boni, Olivier Dumas, Sang Joon Shin, Seth D Rosen, Arvind Chaudhry, Philip R Debruyne, Xiaomin He, Ulka N Vaishampayan, David F Mcdermott

School of Nursing and Midwifery

BACKGROUND: Despite improved outcomes with immune checkpoint inhibitors (ICIs) and their combinations in advanced solid tumors, a subset of patients remains unresponsive or progresses, highlighting an unmet need for novel treatments with durable benefit. Nemvaleukin alfa (nemvaleukin, ALKS 4230) demonstrated manageable safety and antitumor activity, alone and in combination with pembrolizumab, across heavily pretreated advanced solid tumors in the ARTISTRY-1 study. We report in-depth antitumor activity, safety, pharmacokinetics, and pharmacodynamics of nemvaleukin monotherapy at the recommended phase 2 dose (RP2D) in advanced melanoma and renal cell carcinoma (RCC) cohorts from ARTISTRY-1.

METHODS: ARTISTRY-1 was a three-part (A, B, and C), …

Students' Social Attitudes Towards Students With Disabilities And Social Guidance In Inclusive Elementary Schools, Joko Yuwono, Ren Wenas, Nazmin Binti Abdullah, Mahardika Supratiwi, Fadjri Kirana Anggarani, Citra Tectona

Buletin Konseling Inovatif

Teachers in elementary schools have a strategic role in providing social guidance to students to accept the presence of Students with Disability (SwD). The aims of this study were to determine the social attitudes of students, how teachers provide social guidance for non-disability students regarding the presence of disabled students in class/school and describe the challenges faced by teachers. This study uses a mixed method approach (Quantitative and Qualitative). This research method uses a data collection technique, namely a questionnaire distributed via Google Form to teachers in Indonesia. Through the questionnaire, quantitative data (percentage) and qualitative data were obtained regarding …

I’D Rather (S)He Was Dead: Resurrection & Gender Transition In Superhero Comics, Jonathan Sexton, Eitan Runyan

Online Midwinter Seminar (OMS)

No abstract provided.

The Tragedy Of Arwen Evenstar In “The Tale Of Aragorn And Arwen” And In Her Legacy On Film, Nicole Duplessis

Online Midwinter Seminar (OMS)

No abstract provided.

Improving Icu Decolonization Compliance Among Nursing Staff, Sarah J. Moore

Student Scholarly Projects

Practice Problem: Hospital acquired infections (HAIs) burden patients and health care organizations by influencing extended hospital stays, increasing mortality risk, and increasing healthcare spending.

PICOT: The Doctor of Nursing Practice (DNP) Scholarly Project was guided by the PICOT question: In ICU nursing staff (P), how does the implementation of a standardized process with visual reminders and checklists (I) compared to no reminders or checklists (C) impact compliance with the decolonization protocol for HAI reduction (O) over four weeks?

Evidence: A review of evidence-based literature demonstrated efficacy in the reduction of HAIs through once daily bathing with 2% chlorhexidine gluconate (CHG) …

Enhancing Patient Positioning Accuracy: Evaluating Daily Cone Beam Computed Tomography In The Halcyon System., Duong Thanh Tai, Luong Tien Phat, Tran Trung Kien, Nguyen Ngoc Anh, Nguyen Xuan Hai, Peter Sandwall, David Bradley, James C L Chow

Oncology Articles

BACKGROUND: Precise patient positioning is crucial for successful radiotherapy, ensuring accurate delivery of radiation to tumors while minimizing exposure to healthy tissues. Positional errors can significantly impact treatment efficacy and increase side effects. This study evaluates the effectiveness of daily cone beam computed tomography (CBCT) imaging in the Halcyon system for detecting and correcting patient misalignments across various cancer types and treatment sites.

METHODS: A retrospective analysis was conducted on 411 patients treated with the Varian Halcyon linear accelerator from August 2022 to August 2024. Patients were grouped based on tumor location: Head and Neck (118 patients), Chest (188 patients), …

The Development Of A Remediation Policy For High-Stakes Standardized Tests, Abigail R. Brundige

Doctor of Nursing Practice Projects

Standardized testing serves as a measure of academic progress and readiness for licensure in nursing programs. Gaps in standardized testing performance emphasize the need for educational support. The problem identified for this Doctor of Nursing Practice (DNP) policy project is the lack of a formal standardized testing remediation policy within a community college nursing program in rural West Tennessee. The DNP project proposes the development and implementation of a standardized testing remediation policy to identify at-risk students early, provide individualized remediation plans, and improve program retention and licensure pass rates. The DNP project employed a quantitative design to assess the …

Barriers To Participation In Follow-Up Services In Oncology, Casey Wagman

DNP Projects

Background
Psychological distress is often seen in cancer patients due to the physical, emotional, and social burdens of diagnosis and treatment. Patient participation in support services remains low despite the readily available psychosocial resources. The Emotional Well-Being Tool (EWBT), a validated psychological distress screening tool, is often used in a Midwest cancer clinic, yet it was noted that its supportive services were underutilized.

Purpose
This quality improvement project aimed to analyze the perspective of cancer patients on the EWBT, their understanding of its purpose and outcomes, and the perceived barriers to utilizing supportive services.

Methods
It was an exploratory design, …

The Use Of Debriefing To Combat Compassion Fatigue Among Cardiac Intensive Care Nurses, Brittany Johnson

DNP Projects

Background:
Compassion fatigue has physical, emotional, and psychological impacts on nurses working in intensive care units. Debriefing sessions can be used to help reduce compassion fatigue by allowing nurses on a cardiac intensive care unit to discuss their thoughts and feelings after the death of a patient who has had a complex hospital stay or traumatic death.

Aim:
The purpose of this project was to assess the perception of compassion fatigue on work life among Cardiovascular Intensive Care Unit (CVICU) nurses and to evaluate whether debriefing sessions following demanding situations enhance nurses' coping abilities and emotional processing.

Methods:
Nurses working …

Silicon Is The Next Frontier In Plant Synthetic Biology, Aniruddha Acharya, Kaitlin Hopkins, Tatum Simms

Faculty Publications - Biological Sciences

Silicon has a striking similarity to carbon and is found in plant cells. However, there is no specific role that has been assigned to silicon in the life cycle of plants. The amount of silicon in plant cells is species specific and can reach levels comparable to macronutrients. Silicon is used extensively in artificial intelligence, nanotechnology, and the digital revolution, and thus can serve as an informational molecule such as nucleic acids. The diverse potential of silicon to bond with different chemical species is analogous to carbon; thus, it can serve as a structural candidate similar to proteins. The discovery …

Recent Advances In Developing Cell-Free Protein Synthesis Biosensors For Medical Diagnostics And Environmental Monitoring, Tyler P. Green, Joseph P. Talley, Bradley Charles Bundy

Faculty Publications

Cell-free biosensors harness the selectivity of cellular machinery without living cells’ constraints, offering advantages in environmental monitoring, medical diagnostics, and biotechnological applications. This review examines recent advances in cell-free biosensor development, highlighting their ability to detect diverse analytes including heavy metals, organic pollutants, pathogens, and clinical biomarkers with high sensitivity and specificity. We analyze technological innovations in cell-free protein synthesis optimization, preservation strategies, and field deployment methods that have enhanced sensitivity, and practical applicability. The integration of synthetic biology approaches has enabled complex signal processing, multiplexed detection, and novel sensor designs including riboswitches, split reporter systems, and metabolic sensing modules. …

Imputation Via Domain Adaptation: Rethinking Variable Subset Forecasting From Knowledge Transfer, Runchang Liang, Qi Hao, Yue Gao, Kunpeng Liu, Lu Jiang, Pengyang Wang, Minghao Yin

Computer Science Faculty Publications and Presentations

Multivariate time series forecasting in practical deployment faces a critical challenge termed Variable Subset Forecasting (VSF), where certain variables accessible during training are entirely missing during inference. This creates a stark discrepancy between the training (source domain with full variables) and inference (target domain with partial variables) environments, disrupting cross-variable dependencies and fragmenting global temporal patterns. Existing imputation methods, limited to transferring local knowledge (e.g., temporal neighbors or pairwise correlations), fail to capture essential global dynamics, leading to severe performance degradation under distribution shifts. To address these challenges, we redefine VSF as a cross-domain knowledge transfer problem and propose VIDA, …

Evaluation Of Mrcat As A Surrogate For Traditional Ct Simulation In Proton Prostate Radiotherapy Planning, Karen Weeks

Masters Projects

Purpose:

This study evaluated whether Philips MRCAT-generated synthetic CT (sCT) can serve as a clinically viable substitute for traditional CT (CT) simulation in proton therapy planning for prostate radiotherapy using a double-scatter technique.

Methods:

Ten prostate cancer patients treated with proton therapy between 2024 and 2025 were retrospectively analyzed. Each patient underwent both CT and MRI in the treatment position. MRCAT sCT images were generated using atlas-based and segmentation algorithms. The original proton treatment plan was transferred onto the MRCAT dataset. Dosimetric parameters, target coverage, organ-at-risk (OAR) doses, and Hounsfield Unit (HU) values were compared. The sign(M) test …

Working Memory In Major Depressive Disorder: A Meta-Analysis Of Structural And Functional Brain Differences, Eunji Back

Master's Theses

Major depressive disorder (MDD) is one of the most prevalent mental health disorders in the US and is characterized by depressed mood and loss of interest. Many MDD patients also experience difficulties with executive function, including working memory. Neuroimaging studies reveal structural and functional brain differences between MDD patients and healthy controls that may underlie these working memory difficulties, but findings have been mixed. A quantitative synthesis of neuroimaging data through a meta-analytic approach offers a promising avenue to identify commonalities across studies. We conducted separate meta?analyses of structural and functional magnetic resonance imaging (MRI) data, with the latter focused …

Stem Cell-Derived Corneal Epithelium: Engineering Barrier Function For Ocular Surface Repair, Emily Elizabeth Fresenko, Jian-Xing Ma, Matthew Giegengack, Atalie Carina Thompson, Anthony Atala, Andrew J W Huang, Yuanyuan Zhang

2020-Current year OA Pubs

The cornea, the transparent anterior window of the eye, critically refracts light and protects intraocular structures. Corneal pathologies, including trauma, infection, chemical injury, metabolic diseases, genetic conditions, and age-related degeneration, can lead to significant visual impairment. While penetrating keratoplasty or full-thickness corneal transplantation remains a standard and effective intervention for severe corneal dysfunction, limitations in donor tissue availability and the risk of immunogenic graft rejection necessitate alternative therapeutic strategies. Furthermore, for cases of isolated epithelial disfunction, a full-thickness cornea graft may not be required or effective. This review examines the potential of corneal epithelial constructs derived from autologous stem cells …

Physical And Mental Health Of Behavioural Health Certified Peer Specialists In Four Us States, Judith A. Cook, Jane K. Burke-Miller, Morgan Pelot, Jessica A. Jonikas, Laysha Ostrow

Psychology Faculty Publications and Presentations

Background:

Little is known about the health and healthcare needs of the behavioural health peer specialist workforce in the USA. This study explored the physical and mental health-related quality of life (QOL) of a US multistate cohort of certified peer specialists, and factors associated with health-related work absences among those employed in peer specialist positions.

Methods:

Data come from 419 participants surveyed 18 months after state certification as part of a 2-year longitudinal cohort study of peer specialists in four US states. Measures included the Veterans RAND 12 Item Health Survey, the Epidemic-Pandemic Impacts Inventory and items from the National …

Magnet Council Toolkit For Organizations Seeking Magnet Status And Recruitment, Andrew J. Boone

Student Scholarly Projects

Practice Problem: The problem was a lack of a standardized or structured process for the development of Magnet Councils. There is no clear pathway or materials to initiate the process, and one must start by applying to the American Nurses Credentialing Center (ANCC) with little guidance prior to seeking help on the Magnet Journey. PICO Question: The PICO question that guided this DNP Project Toolkit development was as follows: For healthcare organizations pursuing Magnet status (P), how does the development of a structured Magnet Council Toolkit (I) compared to the absence of a formal toolkit (C), contribute to the validation …

Sos (Save Our Skin)- A Hospital Acquired Pressure Injury Reduction Quality, Nicholas A. La Mar

Master's Projects and Capstones

Problem: Hospital-acquired pressure injuries (HAPIs) are a significant source of preventable harm. Often associated with increased patient morbidity, reduced quality of life, and substantial financial costs. In 2023, a Northern California level II trauma center reported 44 HAPI cases, with 25% occurring in the telemetry units. Despite a hospital-wide reduction in HAPIs in 2024, telemetry units accounted for 33% of the cases in the first quarter of 2025, highlighting a need for targeted intervention.

Context: The project was conducted in four adult inpatient telemetry units of a 241-bed level two trauma center. The units faced challenges with inconsistent adherence to …

Partial Cystectomy For Muscle-Invasive Bladder Cancer, Peter S Palencia, Nethusan Sivanesan, Syed Rahman, Fady Ghali, David Hesse, John Colberg, Ashwin Sridhar, John D Kelly, Byron H Lee, Ashish M Kamat, Wei-Shen Tan

Faculty, Staff and Student Publications

Partial cystectomy is a surgical bladder-sparing option for selected patients with muscle-invasive bladder cancer (MIBC), urachal adenocarcinoma and diverticular bladder tumors. Partial cystectomy hold several advantages. It allows for definite pathology and accurate staging while avoiding side effects from radiation therapy and preserves the option for salvage radical therapy (radical cystectomy or radical radiotherapy). Patients should have a CT urogram, prostatic urethral biopsy and mapping biopsies or blue light cystoscopy to rule out multifocal disease or CIS. Small solitary MIBC patients without carcinoma in situ in an area of the bladder where resection can be performed with negative margin would …

Bcl-2/Bcl-Xl Dual Inhibition Triggers Gasdermin D-Mediated Pyroptosis In Mantle Cell Lymphoma, Yijing Li, Joseph Mcintosh, Vivian Jiang, Fangfang Yan, Jovanny Vargas, Yuxuan Che, Wei Wang, Ching-Fei Li, Yue Fei, Celeste Lee, Lei Nie, Yixin Yao, Michael Wang, Heng-Huan Lee, Yang Liu

Faculty, Staff and Student Publications

No abstract provided.

August 2025, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

• Yoga classes coming 9/16 - 10/14
• National Wellness Month
• 5 Habits of Self-Care
• Vaccines and Immunization
• Zucchini Brownies!
• Family Fun Month - Ideas!
• Standing Desks Available
• Word Search

Sex, The Body, And Learning Gender: Demons In The World Of The Five Gods, Erin Mcbrien

Online Midwinter Seminar (OMS)

No abstract provided.

Reimagining Human-Nonhuman Friendships Through Feminist Animal Studies: An Exploration Of Sunny And Della’S Cross-Species Friendship In Nnedi Okorafor’S The Nsibidi Scripts Series, Akshitha Javahar

Online Midwinter Seminar (OMS)

No abstract provided.

Examination Of The Irs’S Voluntary Disclosure Policy, Jerome S. Horvitz, Henri L. Tallichet

Tax Adviser

No abstract provided.

Estate Planning: Planning For The Transfer Of A Personal Residence, Thomas M. Porcano

Tax Adviser

No abstract provided.

Staff Education On Depression Screening In Young Adults, Irene Micere Njeru

Walden Dissertations and Doctoral Studies

Summary This doctoral project was on staff education. The practice problem was a knowledge deficit regarding depression screening by staff nurses at a local acute inpatient psychiatric facility. The practice-focused question was as follows: Will education on depression screening for young adults (18-to-28-year-olds) increase knowledge on the use of evidence-based depression screening tools by nursing staff in an inpatient psychiatric crisis facility? The purpose of the doctoral project was to educate staff nurses at a local acute inpatient psychiatric facility on the PHQ-9 depression screening tool for individuals aged 18 to 28 years. The project included a PowerPoint presentation, a …

The Lived Experience Of The Orgasm Gap In U.S. Cisgender Women In Heterosexual Relationships, Alina Beverly Vergara-Hegi

Walden Dissertations and Doctoral Studies

Women are not orgasming as often as men in heterosexual sexual encounters. Research has confirmed that sociocultural influences, gender differences, sexual perceptions, sexual miseducation, and relationship dynamics contribute to women’s negative sexual experiences. What has been missing is a better understanding of the experience of the orgasm gap and the role of gender ideology in women’s sexual experiences. This study explored the lived experience of the orgasm gap and gender ideology in nine cisgender women in long-term heterosexual relationships. Critical feminist theory was used as the lens to explore the meaning of sexual inequities in intimate long-term relationships. Using interpretative …

The Relationship Between Federal Employees' Viewpoints On Intrinsic Meaningful Work In The Extrinsic Work Unit Environment And Job Satisfaction., Sandra Kunz

Walden Dissertations and Doctoral Studies

Managers are concerned with low job satisfaction since it is a prediction of decreased productivity and increased turnover. Framed within the two-factor theory, the purpose of this quantitative correlational post-facto study was to examine the relationship between intrinsic meaningful work in the extrinsic work unit environment and job satisfaction. The participants were 1,378 U.S. federal employees from the Office of Personnel Management who completed the Federal Employee Viewpoint Survey in 2023. The results of the multiple linear regression were significant, F(2, 1375) = 900.817, p < .001, R² = .567. Recommendations for managers include aligning employees with positions that reflect their skills and interests, enhancing communication regarding the significance of individual contributions, seeking out employee feedback, and resolving any work environment challenges to foster greater job satisfaction. The implications for positive social change include the possibility for managers to advance effective leadership and communication, thereby enhancing the work environment for employees and the quality of service to customers.

Evaluating Virtual Group Coaching’S Impact On Self-Determination In Spinal Cord Injury, Alana Scalzo, Ms, Otr/L

Post-Professional Occupational Therapy Doctorate Culminating Presentations

Introduction: Spinal cord injury (SCI) is a lifelong condition that requires effort and adjustment for managing physical, psychological, and social well-being to have the ability to engage in meaningful activities. As people living with SCI have higher rates of isolation and social disconnect, it is important to study group level approaches for addressing mental health.

Objectives: To determine the impact of virtual group coaching to enhance occupational performance, satisfaction, self-efficacy and relationship closeness in people living with SCI.

Methods: A quasi-experimental single-group pre/post-test design was used. Adults with SCI were recruited through online flyers, social media, newsletters, support groups, clinics, …

Correlation Measures In Metagenomic Data: The Blessing Of Dimensionality, Alessandro Fuschi, Alessandra Merlotti, Thi Dong Binh Tran, Hoan Nguyen, George M. Weinstock

Faculty Research 2025

Microbiome analysis has revolutionized our understanding of various biological processes, spanning human health and epidemiology (including antimicrobial resistance and hor- izontal gene transfer), as well as environmental and agricultural studies. At the heart of microbiome analysis lies the characterization of microbial communities through the quantification of microbial taxa and their dynamics. In the study of bacterial abundances, it is becoming more relevant to consider their relationship, to embed these data in the framework of network theory, allowing characterization of features like node relevance, pathways, and community structure. In this study, we address the primary biases encoun- tered in reconstructing networks …