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2022

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Strategies To Mitigate Voluntary Employee Turnover, Mutale Chilangwa Chisela Jan 2022

Strategies To Mitigate Voluntary Employee Turnover, Mutale Chilangwa Chisela

Walden Dissertations and Doctoral Studies

AbstractBanking leaders are negatively affected when employees voluntarily leave their employment. Banking leaders who implement strategies can enhance employee satisfaction to mitigate voluntary employee turnover. Grounded in the transformational leadership theory, the purpose of this qualitative multiple-case study was to explore strategies some banking leaders use to mitigate voluntary employee turnover. Participants were five banking leaders from local and international banks, four banks in Lusaka, Zambia, and one bank in Dar es Salaam, Tanzania, who successfully implemented strategies to mitigate voluntary employee turnover. Data were collected from semistructured interviews and company documents and analyzed using Yin’s five phases. Three themes …


Implementation Barriers To Integrating Exercise As Medicine In Oncology: An Ecological Scoping Review, Mary A. Kennedy, Sara Bayes, Robert U. Newton, Yvonne Zissiadis, Nigel Spry, Dennis Taaffe, Nicolas H. Hart, Daniel A. Galvao Jan 2022

Implementation Barriers To Integrating Exercise As Medicine In Oncology: An Ecological Scoping Review, Mary A. Kennedy, Sara Bayes, Robert U. Newton, Yvonne Zissiadis, Nigel Spry, Dennis Taaffe, Nicolas H. Hart, Daniel A. Galvao

Research outputs 2014 to 2021

Purpose

While calls have been made for exercise to become standard practice in oncology, barriers to implementation in real-world settings are not well described. This systematic scoping review aimed to comprehensively describe barriers impeding integration of exercise into routine oncology care within healthcare systems.

Methods

A systematic literature search was conducted across six electronic databases (since 2010) to identify barriers to implementing exercise into real-world settings. An ecological framework was used to classify barriers according to their respective level within the healthcare system.

Results

A total of 1,376 results were retrieved; 50 articles describing implementation barriers in real-world exercise oncology …


Kissing, Grabbing And Grinding: Young Australians’ Personal And Social Norms Regarding Nightlife Sexual Behavior, Aimee-Rose Wrightson-Hester, Alfred Allan, Maria Allan Jan 2022

Kissing, Grabbing And Grinding: Young Australians’ Personal And Social Norms Regarding Nightlife Sexual Behavior, Aimee-Rose Wrightson-Hester, Alfred Allan, Maria Allan

Research outputs 2014 to 2021

Many patrons in nightlife settings around the world experience and engage in behavior that some find distressing and others find a useful method of interacting with potential sexual partners. Some of these behaviors nevertheless meet the World Health Organizations’ definition of sexual violence. Recent research suggests the social norms in Australian nightlife settings might be encouraging patrons to engage in or tolerate sexual violence when it occurs, even though it violates their own personal norms. Our main aim was to clarify young Australian nightlife patrons’ personal and descriptive norms regarding three sexual behaviors (Kissing, Grabbing and Grinding), to identify their …


An Aphasia Research Agenda – A Consensus Statement From The Collaboration Of Aphasia Trialists, Myzoon Ali, Efstathia Soroli, Luis M. T. Jesus, Madeline Cruice, Jytte Isaksen, Evy Visch-Brink, Kleanthes K. Grohmann, C. Jagoe, Tarja Kukkonen, Spyridoula Varlokosta, Carlos Hernandez-Sacristan, Vicente Rosell-Clari, Rebecca Palmer, Silvia Martinez-Ferreiro, Erin Godecke, Sarah J. Wallace, Ruth Mcmenamin, David Copland, Caterina Breitenstein, Audrey Bowen, Ann-Charlotte Laska, Katerina Hilari, Marian C. Brady Jan 2022

An Aphasia Research Agenda – A Consensus Statement From The Collaboration Of Aphasia Trialists, Myzoon Ali, Efstathia Soroli, Luis M. T. Jesus, Madeline Cruice, Jytte Isaksen, Evy Visch-Brink, Kleanthes K. Grohmann, C. Jagoe, Tarja Kukkonen, Spyridoula Varlokosta, Carlos Hernandez-Sacristan, Vicente Rosell-Clari, Rebecca Palmer, Silvia Martinez-Ferreiro, Erin Godecke, Sarah J. Wallace, Ruth Mcmenamin, David Copland, Caterina Breitenstein, Audrey Bowen, Ann-Charlotte Laska, Katerina Hilari, Marian C. Brady

Research outputs 2014 to 2021

Coordination of international aphasia research would minimise duplication of effort, support synergistic international activities across languages and multidisciplinary perspectives, and promote high-quality conduct and reporting of aphasia research, thereby increasing the relevance, transparency, and implementation of findings. The Collaboration of Aphasia Trialists (CATs) sought to develop an aphasia research agenda to direct future research activities, based on priorities shared by people with aphasia, family members, and healthcare professionals. Our established international research network spanning 33 countries contributed to this activity. Research literature reporting the priorities of stakeholders was reviewed and synthesized (phase 1). Representatives from Working Groups on Aphasia Assessment …


Alzheimer's Disease Research Progress In Australia: The Alzheimer's Association International Conference Satellite Symposium In Sydney, Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jürgen Götz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori Nakamura, Giulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson Jan 2022

Alzheimer's Disease Research Progress In Australia: The Alzheimer's Association International Conference Satellite Symposium In Sydney, Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jürgen Götz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori Nakamura, Giulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson

Research outputs 2014 to 2021

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms …


Patients’ Experiences Of A Communication Enhanced Environment Model On An Acute/Slow Stream Rehabilitation And A Rehabilitation Ward Following Stroke: A Qualitative Description Approach, Sarah D'Souza, Deborah J. Hersh, Erin Godecke, Natalie Ciccone, Heidi Janssen, Elizabeth Armstrong Jan 2022

Patients’ Experiences Of A Communication Enhanced Environment Model On An Acute/Slow Stream Rehabilitation And A Rehabilitation Ward Following Stroke: A Qualitative Description Approach, Sarah D'Souza, Deborah J. Hersh, Erin Godecke, Natalie Ciccone, Heidi Janssen, Elizabeth Armstrong

Research outputs 2014 to 2021

Background

Patients in hospital following stroke express a desire to continue therapy tasks outside of treatment activities. However, they commonly describe experiences of boredom and inactivity. An enriched environment aims to provide opportunities for physical, cognitive and social activity and informed the development of a Communication Enhanced Environment (CEE) model to promote patient engagement in language activities.

Purpose

Explore patient perceptions of a CEE model, and barriers and facilitators to engagement in the model.

Methods

A qualitative description study from a larger project that implemented a CEE model into acute and rehabilitation private hospital wards in Western Australia. Semi-structured interviews …


Combination Fixed-Dose Β Agonist And Steroid Inhaler As Required For Adults Or Children With Mild Asthma: A Cochrane Systematic Review, Iain Crossingham, Sally Turner, Sanjay Ramakrishnan, Anastasia Fries, Matthew Gowell, Farhat Yasmin, Rebekah Richardson, Philip Webb, Emily O'Boyle, Timothy S. C. Hinks Jan 2022

Combination Fixed-Dose Β Agonist And Steroid Inhaler As Required For Adults Or Children With Mild Asthma: A Cochrane Systematic Review, Iain Crossingham, Sally Turner, Sanjay Ramakrishnan, Anastasia Fries, Matthew Gowell, Farhat Yasmin, Rebekah Richardson, Philip Webb, Emily O'Boyle, Timothy S. C. Hinks

Research outputs 2014 to 2021

Background:

In people with mild asthma poor adherence to regular therapy is common and increases the risk of exacerbations, morbidity and mortality. The use of fixed-dose combination inhalers containing an inhaled corticosteroid (ICS) and a fast-acting β2-agonist (FABA) is established in moderate asthma, but they may also have potential utility in mild asthma.

Objectives:

To evaluate the efficacy and safety of single combined FABA/ICS inhaler only used as needed in people with mild asthma. Design and setting: Cochrane meta-analysis of available trial data.

Participants:

Children aged 12+ and adults with mild asthma. Search methods: We searched the Cochrane Airways Trials …


Reasons For Home Educating In Australia: Who And Why?, Eileen Slater, Kate Burton, Dianne Mckillop Jan 2022

Reasons For Home Educating In Australia: Who And Why?, Eileen Slater, Kate Burton, Dianne Mckillop

Research outputs 2014 to 2021

Home education is a legal educational option in Australia that continues to rise in popularity. This paper summarises the demographics and influences upon the decision to home educate of 385 home education families from Australia, representing 676 children who were home educated at the time of questionnaire completion. The research suggests female caregivers with higher levels of educational achievement than the general population predominantly coordinate home education. Some families eschewed mainstream education for philosophical reasons whilst others home educated due to perceived necessity. However, characteristic of both groups was the belief that the current education system was unable to provide …


Developing A Community Rehabilitation And Lifestyle Service For A Remote Indigenous Community, Alice Cairns, Lynore Geia, Sylvia Kris, Elizabeth Armstrong, Amy O’Hara, Danielle Rodda, Robyn Mcdermott, Ruth Barker Jan 2022

Developing A Community Rehabilitation And Lifestyle Service For A Remote Indigenous Community, Alice Cairns, Lynore Geia, Sylvia Kris, Elizabeth Armstrong, Amy O’Hara, Danielle Rodda, Robyn Mcdermott, Ruth Barker

Research outputs 2014 to 2021

Purpose

Community rehabilitation is an essential health service that is often not available to remote Australians. This paper describes the first cycle of a collaborative project, between local community members, allied health professionals and a university, to co-design a community rehabilitation and lifestyle service to support adults and older people to stay strong and age well in place.

Methods

An action research framework was used to develop the service for adults in two remote communities, one being a discrete Aboriginal community. The first cycle involved planning for, and trialling of a service, with observations, reflections and feedback from clients, community …


Machine Infelicity In A Poignant Visitor Setting: Comparing Human And Ai’S Ability To Analyze Discourse, Martin Maccarthy, Hairong Shan Jan 2022

Machine Infelicity In A Poignant Visitor Setting: Comparing Human And Ai’S Ability To Analyze Discourse, Martin Maccarthy, Hairong Shan

Research outputs 2014 to 2021

This study compares the efficacy of computer and human analytics in a commemorative setting. Both deductive and inductive reasoning are compared using the same data across both methods. The data comprises 2490 non-repeated, non-dialogical social media comments from the popular touristic site Tripadvisor. Included in the analysis is participant observation at two Anzac commemorative sites, one in Western Australia and one in Northern France. The data is then processed using both Leximancer V4.51 and Dialectic Thematic Analysis. The findings demonstrate artificial intelligence (AI) was incapable of insight beyond metric-driven content analysis. While fully deduced by human analysis the metamodel was …


Between Activism And Academia: Zine-Making As A Feminist Response To Covid-19, Emily M. Gray, Joanna Pollitt, Mindy Blaise Jan 2022

Between Activism And Academia: Zine-Making As A Feminist Response To Covid-19, Emily M. Gray, Joanna Pollitt, Mindy Blaise

Research outputs 2014 to 2021

This paper gives an account of a series of three Zoom zine-making workshops run between March and July 2020 that were themed the political, the personal and the practical. A micro-reading of the zines is offered as data that mirror the aims of the workshops, to queer time by slowing down and creating a pause. The process of zine-making as feminist praxis is examined, and the zines themselves are discussed as data that reflect specific moments in time during the early phases of the pandemic. By inviting everyday feminist academic workers, from PhD candidates to professors to participate in a …


Rethinking Arts-Based Research Methods In Education: Enhanced Participant Engagement Processes To Increase Research Credibility And Knowledge Translation, Julia E. Morris, Lisa Francesca Paris Jan 2022

Rethinking Arts-Based Research Methods In Education: Enhanced Participant Engagement Processes To Increase Research Credibility And Knowledge Translation, Julia E. Morris, Lisa Francesca Paris

Research outputs 2014 to 2021

Arts-based research is a participatory research practice that is well established in the qualitative field. However, while arts-based research has been defined as the creation of art to generate, interpret or communicate research knowledge, there is exiguous literature on the creation of art to establish trustworthiness in qualitative inquiry. This pilot case study specifically addresses this gap in the exploration of arts-based research practices to determine credibility and dependability. The context of the research was the impact of a Digital Sabbath practice on early career teachers, as teachers within their first five years of teaching are among the most vulnerable …


Educating The Whole Physician: The Case For Teaching The Business Of Medicine, John J. Locurto, Adam V. Ratner Jan 2022

Educating The Whole Physician: The Case For Teaching The Business Of Medicine, John J. Locurto, Adam V. Ratner

Faculty Articles

The century-old medical education paradigm emphasizes the basic sciences and clinical training. While this traditional approach churns out physicians with deep knowledge and technical proficiency, it does not prepare them for the business of practicing medicine. By omitting the business of medicine from their curricula, medical schools squander a chance to ready their students for the commercial, regulator, and legal environments in which they will treat patients. The cost of this omission is more than just a missed opportunity. Unprepared students are prone to exploitation, frustration, and burnout. While there may be no easy way to bridge the gulf between …


"Only To Have A Say In The Way He Dies:" Bodily Autonomy And Methods Of Execution, Alexandra L. Klein Jan 2022

"Only To Have A Say In The Way He Dies:" Bodily Autonomy And Methods Of Execution, Alexandra L. Klein

Faculty Articles

Capital punishment is one of the most significant intrusions into a person's bodily autonomy; the state takes a person's life. Even though the state has stripped a person on death row of much of their autonomy and intends to kill them, removing all autonomy, a person sentenced to death may, in some circumstances, choose how they will die. While most states rely on a single method of execution, some states permit a condemned person to choose among two or more methods of execution. Constitutional challenges to methods of execution requires the challenger to demonstrate a substantial risk of severe pain …


Effects Of Different Types Of Augmented Feedback On Spatiotemporal Gait Performance And Intrinsic Motivation With Individuals Post Stroke, Saleh M. Alhirsan Jan 2022

Effects Of Different Types Of Augmented Feedback On Spatiotemporal Gait Performance And Intrinsic Motivation With Individuals Post Stroke, Saleh M. Alhirsan

All ETDs from UAB

After a stroke, an individual can be left with physical and psychological deficits, including decreased walking speed, reduced step length, and reduced intrinsic motivation. These deficits affect their performance during rehabilitation sessions, limit daily activities such as walking and stepping, and restrict participation in social roles that involve mobility. Current clinical practice guidelines recommend providing augmented feedback using virtual reality (VR) to enhance walking outcomes after six months of stroke onset. This dissertation shows two novel VR applications designed, especially for individuals’ post-stroke, to induce their fast-walking speed and maximum step length performance, and intrinsic motivation. Three performance conditions were …


A Framework For Designing Blockchain Systems In A Smart City Setting, Mohammad Alhefdi Jan 2022

A Framework For Designing Blockchain Systems In A Smart City Setting, Mohammad Alhefdi

All ETDs from UAB

As main characteristics of successful smart cities, the high demand for increased data security and accessibility and citizen engagement mean the role of blockchain technology has begun to increase. Nonetheless, blockchain technology also faces several challenges, which have slowed its adoption. In response, this dissertation introduces a framework for designing blockchain systems in a smart city setting and considers the smart city and blockchain challenges. Researchers have proposed several smart city models that study and analyze the complexity of smart cities to improve city security, functionality, services, and smartness. The proposed information-theoretical modeling approach to generate an innovated blockchain model …


Teaching Economic Values: A Mixed Methods Study Of Kindergarten Curricula, Values, Practices, And Teachers' Perspectives In Saudi Arabia, Hanaa Abualsoud Jan 2022

Teaching Economic Values: A Mixed Methods Study Of Kindergarten Curricula, Values, Practices, And Teachers' Perspectives In Saudi Arabia, Hanaa Abualsoud

All ETDs from UAB

The primary purpose of this study was to investigate Saudi teachers' practices in developing economic values for kindergarten children, in Eastern region (Qatif city). The researcher also looked at teachers' awareness of Saudi Vision 2030 educational goals. The research was conducted using a convergent mixed methods design. In the quantitative strand, data was collected from 263 teachers using questionnaires. Data was collected from seven knowledgeable teachers using semi-structured interviews in the qualitative strand. The qualitative and quantitative data were analyzed independently through content analysis for the qualitative data and a Google Forms for quantitative data. Results from both strands were …


Teacher Perception, Experience, And Attitudes On Student Achievement In A Title I High School In Central Alabama, Marvin Augusta Carter Jan 2022

Teacher Perception, Experience, And Attitudes On Student Achievement In A Title I High School In Central Alabama, Marvin Augusta Carter

All ETDs from UAB

The purpose of this study was to share the lived experiences of teachers regarding how they supported student achievement in a Title I high school. After almost 60 years of Title I initiatives, the achievement gap between students in poverty and other more affluent students has not changed in any statistically significant manner (Jimenez-Castellanos, 2010). Due to the lack of academic growth for students in Title I schools as compared to students in non-Title I schools, parents, policymakers, and other stakeholders have increased pressure on educators and educational researchers to identify student achievement barriers and implement the use of effective …


Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury Jan 2022

Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury

All ETDs from UAB

Background: Significant issues of inconsistent patient services in the U.S. health system impact health outcomes and create high cost. Limitations of immobility, inefficiency, and accessibility sacrifice patient treatment, delay recovery, and escalate health risks from the lack of primary care physicians. The primary purpose of this study was to examine meVisit, a connective mobile technology, as a feasible primary care solution to address escalating health costs by reducing emergency room (ER) visits and inpatient admissions (IA). Methods: The feasibility study applied descriptive and inferential statistics to secondary data (n=4,024) and compared the two independent patient groups from the same large …


The Relationship Between Nurse And Therapy Staffing Levels And The Medicare Patient-Driven Payment Model Reimbursement During The Covid-19 Pandemic, Roland T. Shapley Jan 2022

The Relationship Between Nurse And Therapy Staffing Levels And The Medicare Patient-Driven Payment Model Reimbursement During The Covid-19 Pandemic, Roland T. Shapley

All ETDs from UAB

The Patient Driven Payment Model (PDPM) brought about a paradigm shift in the way skilled nursing facilities are reimbursed, by linking complexity of care to beneficiary need, expanding case-mix adjusted components by including a non-therapy ancillary and speech language pathology component, and limiting the volume of therapy services provided. The COVID-19 pandemic wreaked havoc upon the nursing home industry that gave rise to high patient and staff infections and fatalities, declining occupancy rates, and nursing shortages, compelling the Department of Health and Human Services to provide $4.9 billion in CARES Funding to skilled nursing facilities (SNFs). Using Payroll Based Journal, …


Applying The Hospitalist Model Of Care To Cardiovascular Acute Care Delivery, Ginger K. Biesbrock Jan 2022

Applying The Hospitalist Model Of Care To Cardiovascular Acute Care Delivery, Ginger K. Biesbrock

All ETDs from UAB

The hospitalist model for managing patients in the hospital setting has been in existence for over 20 years. The hospitalist model for non-specialty care has been found to improve the efficiency of care, maintain quality of care, and support a higher degree of guideline adherence. However, there has been little research focusing on the use of the hospitalist model for specialty care. As cardiovascular programs have begun to adopt the hospitalist model, many are asking if this model is more effective than the traditional model. The main concern is the potential disruption to the patient-physician relationship that occurs with the …


Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton Jan 2022

Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton

All ETDs from UAB

People living with HIV (PLWH) have experienced substantial increases in life expectancy, largely attributable to improvements in care such as antiretroviral therapy. As a result, there has been a concurrent increase in the development of aging-related comorbidities such as end-stage organ disease. One such comorbidity is kidney disease. Concerningly, PLWH are at disproportionately higher risk of chronic kidney disease and end-stage kidney disease (ESKD) as compared to HIV-negative counterparts. Kidney transplantation is the ideal therapy for ESKD as it is both cost-effective and provides a significant survival benefit and yet, despite excellent transplant outcomes among PLWH, access to transplantation among …


Prolonged Prone Positioning For Covid-19-Induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study, David Brian Page Jan 2022

Prolonged Prone Positioning For Covid-19-Induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study, David Brian Page

All ETDs from UAB

ationale: Prone positioning is one of the few interventions shown in a robust, randomized, controlled clinical trial to reduce mortality in severe ARDS. Ideal duration of prone positioning is unknown. A 16-hour prone positioning period has been studied and is considered standard, although longer duration may be beneficial. Objectives: Determine if a prolonged prone positioning strategy for patients with COVID-19-induced ARDS is feasible and safe. Methods: We performed a pilot, randomized, parallel-arm feasibility study in patients with COVID-19-induced ARDS. Patients were randomized to either a prolonged 24-hour or a traditional 16-hour prone positioning strategy. Measurements & Main Results: 52 patients …


The Impact Of The Covid-19 Pandemic On College Students With Disabilities Or Pre-Existing Conditions: A Qualitative Dissertation, Caro Celestine Holmes Wolfner Jan 2022

The Impact Of The Covid-19 Pandemic On College Students With Disabilities Or Pre-Existing Conditions: A Qualitative Dissertation, Caro Celestine Holmes Wolfner

All ETDs from UAB

The COVID-19 pandemic continues to have a global and multifaceted impact on public health. The onset of the pandemic has resulted in widespread campus closures and transitions from in-person classes to online learning, further exacerbating the mental health crisis brought about by the pandemic. The effects of federal and state regulations have influenced the psychological well-being and mental health of many, more notably for college students with disabilities or pre-existing conditions. However, COVID-19 research on college students with disabilities or pre-existing conditions is limited and mostly international, thus it is of great importance to address these limitations. This phenomenological study …


Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu Jan 2022

Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Obesity is a prevalent chronic condition determined by social, psychological, behavioral, and biological factors. The prevalence of obesity remains a major public health issue and has continued to rise in the United States and around the world. People who are obese face a higher risk of cardiovascular and metabolic diseases. The fat mass and obesityassociated gene (FTO) is one of the most commonly identified genes in obesity-related research. This three-paper dissertation is aimed at improving understanding of sex and race differences in obesity risk factors in older Americans from genetic (FTO SNPs) and lifestyle (diet and physical activity) perspectives, using …


Analysing The Structural Dynamics Of Retinoid X Receptor Using Hydrogen Deuterium Exchange Mass Spectrometry, Nathalia Melo Jan 2022

Analysing The Structural Dynamics Of Retinoid X Receptor Using Hydrogen Deuterium Exchange Mass Spectrometry, Nathalia Melo

All ETDs from UAB

Nuclear receptors (NR) are ligand-activated transcription factors that are targets for drug discovery due to their ability to directly modulate gene expression. There are 48 NRs and approximately half of them require heterodimerization with retinoid X receptor (RXR) to function. Targretin (bexarotene) is an FDA-approved RXR specific (rexinoid) currently used to treat Cutaneous T-cell Lymphoma (CTCL); however, it causes hyperlipidemia toxicities. A functionally similar rexinoid developed at UAB, 9-cis-UAB30 (UAB30), is non-toxic and weak agonist in the liver. While UAB30 shows promise as a low toxicity chemopreventative drug, the mechanism of UAB30 action at the molecular level is poorly understood. …


The Potential Roles Of Broccoli Sprouts (Bsp) And Green Tea Polyphenols (Gtps) In Prevention Of Mammary Cancer, Itika Arora Jan 2022

The Potential Roles Of Broccoli Sprouts (Bsp) And Green Tea Polyphenols (Gtps) In Prevention Of Mammary Cancer, Itika Arora

All ETDs from UAB

Cancer is one of the leading causes of death in the United States. Based on the American Cancer Society statistics, in 2021 1,806,590 new cancer cases and 605,520 cancer deaths are projected to occur in the United States. Amongst all, breast cancer (BC) is one of the most prevalent cancers that occurs in women. Various lifestyle factors such as alcohol intake, smoking, an unhealthy diet and physical inactivity may result in increased rates of BC risks (cancer-transition) by inducing mutations in DNA. Numerous epidemiological studies indicate that a diet rich in green tea polyphenols (GTPs), and/or cruciferous vegetables such as …


Elucidating The Role Of Stat4 In Cd4 T Cell Mediated Pathogenicity, Ashlyn E. Anderson Jan 2022

Elucidating The Role Of Stat4 In Cd4 T Cell Mediated Pathogenicity, Ashlyn E. Anderson

All ETDs from UAB

While the exact cause of many autoimmune diseases is currently unknown, many genetic factors are associated with increased disease susceptibility such as single nucleotide polymorphisms in the STAT4 gene locus. Signal Transducer and Activator of Transcription 4 (STAT4) is critical for the development and function of Th1 cells; however, many Th1 associated molecules are dispensable for CD4 mediated inflammation such as IFNγ, T-bet, and IL-12Rβ2, suggesting that STAT4 may function outside of the Th1 cell lineage. Importantly, Stat4 has recently been correlated with an inflammatory Th17 cell phenotype. Using a murine model of neuroinflammation, we illustrate that Th17 intrinsic STAT4 …


Improving Continuity And Quality Assurance In Internet Of Things Infrastructure Using Blockchain, Hussain A. Alshehri Jan 2022

Improving Continuity And Quality Assurance In Internet Of Things Infrastructure Using Blockchain, Hussain A. Alshehri

All ETDs from UAB

In this research I present a rigorous study on the service continuity and quality assurance using the Internet of Things (IoT). The research aims at identifying risks and improving the risk mitigation tools that are currently in use for improving the IoT performance, and for pushing forward the implementation of IoT in mission critical applications. This objective can be accomplished by identifying the impact of the strategic planning, quality assurance, performance assurance, and risk management on the IoT used in businesses. While the focus is mainly on the business continuity domain, the technical aspects of IoT solutions are also covered. …


Factors Influencing Balance And Muscle Tone In Adults With Attention-Deficit/Hyperactivity Disorder, Mansour M. Alotaibi Jan 2022

Factors Influencing Balance And Muscle Tone In Adults With Attention-Deficit/Hyperactivity Disorder, Mansour M. Alotaibi

All ETDs from UAB

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental condition prevalent in children globally and continues to persist into adulthood. Executive function (EF) impairments are core ADHD deficits, specifically response inhibition, and believed to drive ADHD symptoms. Psychostimulant medications (PS) is the first line treatment to manage ADHD symptoms. Overall, individuals with ADHD are at greater risk of falls and physical injuries compared to healthy individuals. Perhaps adults with ADHD balance impairments are secondary to ankle plantarflexor (PF) spasticity. Using psychostimulant medications (PS) improves PF spasticity and postural control in children with ADHD, but the effects on adults with ADHD are unclear. Furthermore, …