An Action Research Evaluation Of An Online Inclusive Sport Peer Coach Training, Margaret Roberts Condon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Trained peer tutors are a proven pedagogical technique that can help eliminate barriers to inclusion in physical education and extracurricular sport, including a reported lack of training and experience of professionals. When adequately trained, peer tutors can encourage social interactions, provide constant feedback, and increase active learning and engagement. While recommendations for training peer tutors have been provided, there are currently no known studies examining a peer tutor training in an online format for middle and high school-aged students participating in an inclusive sport program.

Purpose: The purpose of this study was to evaluate the effectiveness of an …

A Novel Computational Network Methodology For Discovery Of Biomarkers And Therapeutic Targets, Qing Ye

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer has the second highest cancer incidence rate and the top cancer-related mortality worldwide. An estimate from the American Cancer Society shows that, in 2022, there will be about 236,740 lung cancer cases (117,910 men and 118,830 women) in the US. To date, there are no prognostic/predictive biomarkers to select chemotherapy, immunotherapy, and radiotherapy in individual non-small cell lung cancer (NSCLC) patients. There is an unmet clinical need to identify patients with early-stage NSCLC who are likely to develop recurrence and to predict their therapeutic responses. This dissertation developed a novel computational methodology for modeling molecular gene association networks …

A Novel Tool To Promote Surgical Team Awareness Of Nurse Anesthesia Students’ Level Of Training, Joseph Lewis Britz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Communication errors in operating room (OR) settings are a common and avoidable source of patient harm. Communication in OR settings is enhanced when all members of the surgical team have knowledge of the skills and proficiency of their fellow team members. Student registered nurse anesthetists (SRNAs) provide anesthesia under the supervision of a certified registered nurse anesthetist (CRNA) or physician anesthesiologist. SRNAs’ proficiency in delivering anesthesia can vary significantly depending on their level of training, which varies based on the progression of the student in their multi-year nurse anesthesia program. Methods: This quality improvement project implemented a standardized non-verbal …

Love At First Profile: An Experiment Exploring If Previously Incarcerated Individuals Are Less Desirable While Online Dating, Carina L. Perrone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Incarceration is a rapidly increasing occurrence in the United States with more than 1.4 million people incarcerated and more than 2 million on some form of restricted confinement. While men are incarcerated at a much higher rate than women, women are still at a steady incline of incarceration as well. Also, people of color disproportionately make up a large number of those incarcerated while accounting for a small percentage of the general population. Previous research on people who have been incarcerated focuses on it affects education, employment, and marriage. Little research has attempted to explore how incarceration effects dating, a …

Covid-19: Examining Adherence Through The Health Belief Model, Leah Ashton Brown

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over 6.4 million individuals have died due to COVID-19. Although the vaccine has been distributed and made more accessible, it is important for individuals to continue adhering to guidelines that prevent the spread of this deadly virus. The current study explored adherence to COVID-19-related health behaviors (wearing a mask, social distancing, properly washing hands, and receiving the COVID-19 vaccine) in a U.S. sample (recruited through Amazon MTurk) and examined the role of interactions among various identities. The study was informed by the Health Belief Model (HBM) and participants completed questionnaires that assessed COVID-19 health behaviors, constructs comprising the HBM (perceived …

The Business Of Behavior: Appalachian Teachers’ Experiences In Using Positive Behavior Interventions And Support, Erin Michele Coffield

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the lived experiences of Appalachian elementary and middle school teachers who have been identified as working in Positive Behavior Intervention and Support (PBIS) schools. This study used Lifeworld Theory to engage in discussion about the teachers’ individual experiences in using PBIS in their classrooms in relation to resilience frameworks and childhood trauma. The teachers’ individual experiences were analyzed using a Whole-Part-Whole analysis to bring the individual stories together to better understand how PBIS and childhood trauma are experienced in a specific Appalachian school. Discussion opens up through the participants' experiences about grit models in school, trauma their …

Developing Teaching Adaptability In Pre-Service Teachers Using Practice-Based Teacher Education, Kyuil Cho

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to examine how pre-service teachers (PSTs) develop their teaching adaptive competence through teaching rehearsal and repeated teaching, which is one of the focused teacher education strategies in practice-based teacher education (PBTE). This study was conducted in an introductory teaching methods course of a physical education teacher education (PETE) program. A total of 22 PSTs participated in the study. Fourteen were male, and eight were female. The PSTs had varied coaching experiences ranging from little to no coaching in limited recreational sports settings, and none had teaching or coaching experience in the school setting.

A …

First Responders’ Assumptions: An Exploration Of Emergency Medical Technicians’ Secondary Traumatic Stress And Perceptions Of Substance Users, Glenn Noble

Graduate Theses, Dissertations, and Problem Reports (ETD)

Emergency medical technicians (EMT) and firefighters respond to critical incidents and provide emergent care. As the opioid crisis continues and drug overdose rates increase, first responders administer first aid to substance users, including Naloxone, more frequently. This study examined the influence of repeated exposure to drug-related critical incidents and provision of care to substance users on EMTs' and firefighters' secondary traumatic stress (STS) level, world assumptions, and substance use stigma. First responders' world assumptions, STS, burnout, and exposure to drug-related overdoses were analyzed for their power in predicting substance use stigma. Results suggest that occupational burnout, rather than STS, is …

Influences Of Disrupted Circadian Rhythms On Stroke Outcome, Jennifer A. Liu

Graduate Theses, Dissertations, and Problem Reports (ETD)

The circadian system is composed of a subset of temporal oscillators that function through a transcriptional and post-translational molecular and functional negative feedback loop cycling approximately every 24 hours. The central clock located in the suprachiasmatic nucleus is responsible for entrainment using light as the key timekeeper (zeitgeber); it is responsible for synchronizing and optimizing physiological behavior and function to the environment. Exogenous information, such as day length and light-dark cycles, provide critical temporal cues for adjusting to environmental conditions. Proper alignment to natural light dark cycles and circadian rhythms is optimal for vital health, fitness, and survival in organisms. …

Aging, A Pathological Factor In Neurological Injury, Aruvi Vijikumar

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the main reasons for CNS drugs to fail in clinical development is not considering age as a risk factor while studying chronic age-related neurological/neurodegenerative diseases in preclinical studies. We first set out to gain a comprehensive understanding of the impact of age on various aspects (anatomical, immunological, and biochemical) in rodents that play a key role in determining the onset, progression, and evolution of disease severity. With advancing age, the vascular structure and function are compromised which is hypothesized to accelerate cognitive decline. The initial step toward developing novel therapeutics is to characterize the age-related vascular modifications. Utilizing …

A Narrative Inquiry Into The Influence Of School Shooting Survival On College Transition And Experience, Jayne M. Piskorik

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is an extensive body of school-related shooting research exploring causes, how to recognize a threat, and what preparedness measures are effective (Lee et al., 2020; Muchert, 2007). However, there is insufficient research on how the broader context of school-related shootings in American society has influenced college-aged students. The purpose of this study was to tell the story of how students have been influenced by their experience surviving the 2018 Marjory Stoneman Douglas High School shooting during their transition to and performance in higher education. Narrative inquiry provided a deeper understanding through narrative retelling of the perceptions, decisions, and experiences …

Characterizing The Effects Of Solvent And Analyte Properties On Ionization Efficiency By Novel Field-Free And Field-Enabled Ionization Techniques, Kinkini Udara Jayasundara

Graduate Theses, Dissertations, and Problem Reports (ETD)

In recent years the mass spectrometry (MS) area of field and/or direct analysis has grown dramatically. As a result, field-portable and miniaturized mass spectrometers, introduced only a few years ago, are proliferating. A highly desired feature for field-portable MS, or in-field analysis, is the ability to use ionization techniques requiring very little sample preparation as well as an ability to generate the ions under ambient conditions. Recently, a new ambient ionization technique termed vibrating sharp-edge spray ionization (VSSI) has been introduced which overcomes the field-portable limitations of other spray-based methods including the requirements for auxiliary components (e.g., nebulizing gas and …

Implementation Of Stress Management And Resiliency Training To Address Nursing Burnout In A Neuroscience Critical Care Unit, Jessica May Marie Hughes

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, over one-third of nurses experience symptoms of burnout (Reith, 2018). If left unchecked, poor stress management and resiliency skills can contribute to nursing burnout, leading to costly employee turnover. Stress management and resiliency training (SMART) provides the tools necessary to develop resiliency, improve stress management and decrease burnout (Resilient Option, 2020). Nursing staff under the age of 36, who work in a Neurosciences Critical Care Unit (NCCU) demonstrate lower resiliency scores and a higher risk of burnout. This project aimed to evaluate: (a) the effects of a SMART program on the wellbeing of nursing staff in …

Standardized Postoperative Handoff Tool To Improve Handoff Quality, Haley Durkacz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Effective communication between healthcare providers is an essential element in the delivery of safe patient care. Loss of relevant information can occur during all phases of patient care but is most inclined to occur during the handoff from the operating room to the postoperative anesthesia care unit (PACU). Evidence has indicated that the transfer of patients by anesthesia providers remains informal and brief despite practice guidelines. When pertinent details are omitted during the anesthesia handoff there is a potential increase for medical errors, delayed treatment, and patient harm. The purpose of this project was to analyze the use of …

A Quality Improvement Initiative Regarding Ondansetron In The Prevention Of Spinal Anesthesia-Induced Hypotension, Kassidy Dell Nutter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Spinal anesthesia is an excellent choice as the primary anesthetic for lower abdominal, perineal, and lower extremity procedures. Spinal anesthesia boasts several distinct advantages over general anesthesia. However, it is important to note that spinal anesthesia does not come without risk. The most common adverse reaction of spinal anesthesia is hypotension. Anesthesia providers use several methods to combat the hypotension that is so commonly associated with spinal anesthesia. One emerging trend to prevent spinal anesthesia-induced hypotension (SAIH) is the administration of ondansetron, a serotonin 5-hydroxytryptamine3 antagonist. Evidence has shown that the administration of ondansetron just prior to spinal anesthesia administration …

Implementation Of An Amiodarone Infusion Nurse Practice Guideline To Reduce The Incidence Of Phlebitis: A Quality Improvement Project, Kristen N. Cottrill

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Patients have an increased risk of developing phlebitis when amiodarone is delivered through a peripheral intravenous catheter. In a 32-bed cardiac surgery step-down unit, patients experienced phlebitis at a rate of 28.57% despite following manufacturer recommendations. Individual interventions targeted at amiodarone-related phlebitis have presented mixed results, however, when an amiodarone infusion practice guideline was established, the rate and severity of phlebitis consistently decreased across studies. Purpose: This project aimed to implement an evidence-based amiodarone infusion guideline to reduce phlebitis development or severity in cardiac-surgery step-down patients without a central venous catheter who received a peripheral intravenous infusion of amiodarone. …

A Quality Improvement Initiative For Intraoperative Low Dose Ketamine Utilization In Thoracotomy, Jason Wampler

Graduate Theses, Dissertations, and Problem Reports (ETD)

The challenge of postoperative pain control following a thoracotomy is well noted among anesthesia providers. The intraoperative utilization of low-dose ketamine in several patient populations, including those undergoing a thoracotomy, has been deemed a viable intervention in the multi-modal analgesia plan at not only reducing postoperative pain scores for patients, but also reducing opioid consumption. This quality improvement project sought to increase provider awareness of this intervention among anesthesia providers in a community hospital with a goal to influence a practice change. This was completed using a pre-post design centered around an educational in-service, with an additional 60-day follow-up survey …

An Anesthesia-Based Quality Improvement Initiative To Decrease Opioid Administration Via Esmolol Administration, Fredrick J. Hanna

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Laryngoscopy and endotracheal intubation are routine procedures that occur within the surgical setting. Fentanyl is currently administered for attenuating the hemodynamic response to intubation. Opioid-sparing alternatives have been identified with aims of improving patient outcomes, such as esmolol. Purpose: The project’s purpose was designed to improve anesthesia provider familiarity, perception, and consideration of esmolol as a non-narcotic alternative for attenuating the hemodynamic response to intubation and prompt an increase of esmolol administration within this setting. Interventions: Surveys were conducted before and after an educational in-service, offered to anesthesia providers, demonstrating esmolol as an efficacious alternative to fentanyl. Additionally, an …

A Review Of Biomechanics Of Arterial Stent Implants, Joshua Collin Yurek

Mechanical Engineering and Applied Mechanics

This work looks to provide a review of modern stents by evaluating the need for them as well as providing a detailed engineering analysis of the conditions they are subjected to. It is estimated that over two million of these devices are implanted in patients annually. Of those implanted, a majority are used in the treatment of arteriosclerosis. This disease causes arterial walls to thicken and toughen leading to restricted blood flow and in extreme cases, complete loss of circulation. Arteriosclerosis and complications arising from it form a leading cause of death in the developed world. Although there are a …

An Experimental Study Of Fluid-Structure Interaction In Collapsible Vessels, Jennifer Schmeling

Mechanical Engineering and Applied Mechanics

The fluid-structure interaction in collapsible thin-walled vessels is an important topic of research to better understand the physical mechanisms behind many physiological processes and diseases. In this work, we established an experimental setup to study the collapsible tube deformation and fluid-structure interaction within a thin-walled collapsible vessel. The effects of transmural pressure and flow rate were characterized experimentally using high-frequency pressure transducers and optical measurements. Various transmural pressures were also simulated through finite element analysis. Results suggest that the deformation of thin-wall vessel follows the pattern described by Shapiro’s tube law. The collapsed pattern and cross-sectional area changes with different …

Adverse Childhood Experiences And Alcohol Use Trajectories In College Students, Rebekah Lynn Damitz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heavy alcohol use during college can result in numerous negative outcomes (e.g., accidents, worse academics, risky sexual behaviors, etc.). Understanding the risk-factors associated with elevated alcohol use in college are needed so prevention and/or interventions can be implemented to inhibit such dangerous behavior. Adverse childhood experiences have been identified as one key factor in the initiation and escalation of alcohol use, but there is limited research on samples that are in emerging adulthood. Specifically, the transition to college is a time when many students escalate drinking and can form the basis for longer term drinking patterns. It is not yet …

Low- And High-Wattage Vaping During Pregnancy Influence Aortic Structure And Function In Rat Offspring, James Ian Frazier

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Electronic cigarettes (e-cigs) are being marketed as a healthier alternative to traditional cigarettes, yet the health consequences of e-cig usage (also called vaping) are still being investigated. E-cigs are easily customized for user preferences. For example, the choice of flavors, nicotine concentration, and/or the temperature (i.e., wattage) used to heat the e-liquid can be selected in many devices. Emerging evidence suggests that vaping during pregnancy impairs cerebral vascular function in rodent offspring. In this study, we sought to investigate the potential effects of changes to e-cig device wattage (i.e., 5W vs. 30W) with maternal vaping during pregnancy on vascular …

Evaluation Of A Comprehensive Diabetes Mellitus Protocol At A Rural, Federally Qualified Health Center In Southern West Virginia, Hannah D. Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes mellitus is a chronic disease that affects nearly 34 million Americans. In rural Appalachia, the population is affected disproportionately at a rate of 14% compared to the national average of 10%. Diabetes is a lifelong, chronic condition managed best by a multidisciplinary team-based approach to achieve optimal disease control. Best practices in the care of diabetes support the use of evidenced based care protocols and leveraging technology to decrease the burden of disease. Type 2 diabetes mellitus (T2DM) is the most common type, making it the focal population for evaluation.

Purpose: The purpose of this project was to …

Bone Marrow Stroma-Induced Transcriptome Signatures Of Multiple Myeloma As Modulated By Junb, Jasleen Kaur Gandhi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The bone marrow (BM) microenvironment acts as a breeding ground for drug resistance in multiple myeloma (MM). The interaction with bone marrow stromal cells (BMSCs) confer environment-mediated drug resistance (EMDR) to multiple myeloma. We investigated BM stroma-induced transcriptome signatures of MM cells through a sophisticated analysis of gene expression. In particular, we defined transcription program modulated by JunB, an emerging regulator of MM pathogenesis and a member of the transcription factor superfamily activator protein 1 (AP-1), in response to BM stimulation. The data and results lay down a foundation for future studies to illustrate the regulatory role of JunB in …

Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.

Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.

Methods. A sequential explanatory mixed-methods design was used for aims 1 …

Combinatorial Approaches For Effective Design, Synthesis, And Optimization Of Enzyme-Based Conjugates, Jordan Scott Chapman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The specificity and efficiency with which enzymes catalyze selective chemical reactions far exceeds the performance of traditional heterogeneous catalysts that are predominant in industrial applications such as conversion of commodity chemicals to value-added products, fuel cells, and petroleum refinement. Moreover, biocatalysts exhibit exceptionally high product turnover at ambient conditions with little health and environmental burden. These advantageous qualities have led to the prolific use of enzyme catalysis in pharmaceutical, detergents, and food preservation industries wherein their use has greatly reduced waste generation, Unfortunately, the full slate of benefits that enzymes can impart to a broader range of chemical processes is …

A Domain Adaptation Approach For Segmenting Cell Instances In Microscopy Data, Matthew R. Keaton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Automated cellular instance segmentation is a process that has been utilized for accelerating biological research since before the deep learning era, and recent advancements have produced higher quality results with less effort from the biologist. Most current endeavors focus on completely cutting the researcher out of the picture by generating highly generalized models. However, these models invariably fail when faced with novel data and effectively opt to miss out on the full capabilities of deep learning in pursuit of this goal. In our work, we demonstrate how, with even a minimal amount of annotated data, dominant approaches in this space …

Development Of An Entry-Scale Modeling Methodology To Provide Ground Reaction Curves For Longwall Gateroad Support Evaluation, Haochen Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

Longwall gateroad entries are generally subjected to severe mining-induced stress changes and deformations; they are prone to large roof falls, floor heaves, and rib sloughing. The standing support system in underground mines needs to be carefully designed to compensate for the mining-induced deformation of the surrounding rock mass and consecutively protect the integrity of gateroad entries. Local geology, together with mining-induced stress redistribution, influences the ground response and plays a major role in the performance of a standing support design. In the US, Support Technology Optimization Program (STOP) and its Ground Reaction Curve (GRC) design criteria have been applied to …

Incidence Of Cancer, Depression, And Economic Burden Of Prescription Nsaids Among Older Adults With Osteoarthritis: Statistical And Machine Learning Approaches, Nazneen Fatima Mohammed Umer Shaikh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding the role of chronic inflammation among older adults is critical because of its implications on chronic inflammatory conditions as well as its interaction with anti-inflammatory medications. Osteoarthritis (OA) is a heterogeneous multi-faceted joint disease with multi-tissue involvement of varying severity, and increasing evidence demonstrates a key role of chronic inflammation in its pathogenesis. Approximately 30 million adults in the United States have OA, and it is reported that a large proportion (43%) of them are older than 65 years. OA is typically treated using non-steroidal anti-inflammatory drugs (NSAIDs) for minimizing pain and reducing inflammation. NSAIDs have consistently shown clinically …

Development Of An Innovative Co-Treatment Technology For Produced Water And Blowdown Water: A Regional Approach Of Water Management For Energy Production, Golnoosh Khajouei

Graduate Theses, Dissertations, and Problem Reports (ETD)

Freshwater use for power generation represents the second-largest water use globally. In the United States, freshwater withdrawals for thermoelectric power accounted for 38% of the total freshwater withdrawals for all uses in 2010. Cooling systems are the most water-intensive part of the thermoelectric generation process. For instance, one 300 MW power generator required about 20,000 m³/h circulating cooling water. The cooling operation discharges a large volume of wastewater in the form of blowdown water (10-20% of the consumed water) that requires treatment for reuse or surface discharge. Produced water (PW), the fluid which returns to the surface from …