Digital Commons Network^™

Deciphering The Role Of Rna Structure In Translation Efficiency., Jianan Lin, Yang Chen, Yuping Zhang, Haifan Lin, Zhengqing Ouyang

Faculty Research 2022

BACKGROUND: RNA secondary structure has broad impact on the fate of RNA metabolism. The reduced stability of secondary structures near the translation initiation site/start codon of the coding region promotes the efficiency of translation in both prokaryotic and eukaryotic species. However, the inaccuracy of in silico folding and the focus on the coding region limit our understanding of the global relationship between the whole mRNA structure and translation efficiency. Leveraging high-throughput RNA structure probing data in the transcriptome, we aim to systematically investigate the role of RNA structure in regulating translation efficiency.

RESULTS: Here, we analyze the influences of hundreds …

Identification Of North Sea Areas Suitable For Cultivating Saccharina Latissima As An Alternative Source Of Protein, Ella Sykes

The Plymouth Student Scientist

Demands for food resources are increasing with the growing human population and the impacts of climate change on agricultural land. Protein is an essential macronutrient for human well-being and supplies are likely to face a global security crisis in the foreseeable future. However, research has shown that the brown seaweed species Saccharina latissima (S. latissima) could be an alternative plant-based source of protein for human consumption that can be sustainably farmed under North Sea conditions. Yet seaweed farming currently remains an underexploited resource in the United Kingdom (UK). This study aims to identify areas suitable for S. latissima cultivation in …

Assertive Behaviour: Not A One-Size-Fits-All Solution To Poor Psychological Well-Being, Oliwia A. Hryniewska

The Plymouth Student Scientist

Extraversion as both a personality trait and state has robust links with well-being; extraverted state, or behaviour, is sufficient to increase positive affect (PA) regardless of disposition. However, examining extraversion more closely at the aspect and facet level has, to date, yielded mixed results for this relationship. This study sought to clarify extraversion’s impact on psychological well-being (PWB) and positive affect by investigating state and trait assertiveness as one aspect of extraversion (next to enthusiasm; DeYoung et al., 2007). It was hypothesized that this aspect specifically contributes to several PWB outcomes at the trait level, but not at the state …

Biochar Amendment Of A Sandy Loam Improves Wheat Growth Under Drought And Control Conditions, Toby Anderson Von Trampe

The Plymouth Student Scientist

Drought stress is a major limiting factor in cereal crop growth. To meet the feeding requirements of an increasing population, cereal crop yields need to be significantly increased in a sustainable manner. Biochar is a charcoal-like substance derived from organic material. Here, the effects of biochar on wheat (Triticum aestivum L.) growth and stress responses under drought stress conditions were determined. Biochar was applied at 5% (w/w) and stressed plants weren’t watered during the four weeks of drought treatment to establish the rate of water loss in the different soil treatments. drought significantly decreased plant height, stem thickness, number of …

Numerical Models To Track The Origin And Drift Of Pharmaceutical Flotsam In The English Channel, Alizee De Groodt

The Plymouth Student Scientist

Marine plastic pollution is an increasing problem that has serious impacts on the environment. The sources, pathways and fate of plastics in the ocean are still poorly understood, especially for marine pollution coming from marine-based sources. In November 2018, a high number of pharmaceutical bottles named ‘Otrivin’ started to beach in high numbers along the English Channel. Research was initiated to investigate the likely origin of the bottles. In this study, we continue this research using the observational data from 2018-2019 and two numerical ocean models to hindcast the likely origin of the bottles, but also assess whether the effect …

The Relationship Between Diet, Supplement Use, And The Prevalence And Severity Of Nausea And Vomiting During The 1st And 2nd Trimesters Of Pregnancy, Bailey Lentern

The Plymouth Student Scientist

Nausea and vomiting during pregnancy (NVP) are common conditions experienced by women throughout the world. However, despite their widespread occurrence, the prevalence and severity of symptoms range significantly, with the exact aetiology underpinning this variation relatively unclear. Several studies propose that NVP may serve as an adaptive function, protecting the embryo from harmful foodstuffs, implying that diet is implicated within the pathogenesis of the condition. However, there is limited literature focusing on this topic, specifically with regards to supplement use. Therefore, the aim of the present research was to examine the relationship between diet, both pre-pregnancy and current diet, including …

The Impact Of The Covid-19 Pandemic On Risk Factors For Fatal Intimate Partner Violence And Domestic Violence Services Provided, Faith E. Alves

Honors Theses

The current study assessed the COVID-19 pandemic-related changes in risk factors for fatal intimate partner violence (IPV) among female victims. It additionally analyzed IPV services received before and during the pandemic. Data came from a system that most domestic violence (DV) agencies in Connecticut utilize to record their contacts with their clients, including an initial screening through a police-social service intervention. Results indicated that unemployment of the partner was significantly higher in the during-COVID group. Additionally, the delivery of criminal justice services was significantly higher in the pre-COVID group whereas delivery of law enforcement services was significantly higher in the …

A Study On The Effect Of Emotional Efforts Of Academicians In Tourism Departments On Job Stress, Hasan O. Seyhanlioglu, Sevki Ulema

Journal of Mediterranean Tourism Research

The aim of this study is to examine the emotional labor and job stress levels of tourism academicians who train sector managers. The t-test and One-Way ANOVA analysis were conducted to determine whether there is a difference between the quantitative data collected from 346 individuals working as academicians in tourism departments operating in Turkey and the demographic characteristics of the variables. In addition, explanatory factor analysis was performed for the emotional labor scale. As a result, it has been observed that the stress level is high in academicians who have just started their profession.

Hiv-Tat Exacerbates The Actions Of Atazanavir, Efavirenz, And Ritonavir On Cardiac Ryanodine Receptor (Ryr2), Imam Abdulrahman Bin Faisal University, Chengju Tian, Sean R. Bidasee, Zachary L. Venn, Evan Schroder, Nick Y. Palermo, Mohammad Alshabeeb, Benson J. Edagwa, Jason J. Payne, Keshoer R. Bidasee

Department of Biochemistry: Faculty Publications

The incidence of sudden cardiac death (SCD) in people living with HIV infection (PLWH), especially those with inadequate viral suppression, is high and the reasons for this remain incompletely characterized. The timely opening and closing of type 2 ryanodine receptor (RyR2) is critical for ensuring rhythmic cardiac contraction–relaxation cycles, and the disruption of these processes can elicit Ca²⁺ waves, ventricular arrhythmias, and SCD. Herein, we show that the HIV protein Tat (HIVTat: 0–52 ng/mL) and therapeutic levels of the antiretroviral drugs atazanavir (ATV: 0–25,344 ng/mL), efavirenz (EFV: 0–11,376 ng/mL), and ritonavir (RTV: 0–25,956 ng/mL) bind to and modulate the …

Multiomics Approach Captures Hepatic Metabolic Network Altered By Chronic Ethanol Administration, Isin Tuna Sakallioglu, Bridget Tripp, Jacy Kubik, Carol A. Casey, Paul G. Thomes, Robert Powers

Department of Chemistry: Faculty Publications

Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic ethanol administration. A functional enrichment analysis of the multiomics dataset revealed that rats treated with ethanol experienced an increase in hepatic fatty acyl content, which is consistent with an initial development of steatosis. The nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography–mass spectrometry (LC-MS) metabolomics data revealed that the chronic ethanol exposure selectively modified toxic substances such as an increase in glucuronidation tyramine and benzoyl; and a depletion in cholesterol-conjugated glucuronides. Similarly, the lipidomics results revealed that ethanol …

Using Naming Conventions To Facilitate Data Transfer Between Asset Management Systems And Building Information Models, John D. Foster

Theses and Dissertations

An improvement to the workflow developed by Loeh et al. (2021) is proposed using a Revit template with BUILDER SMS naming conventions when creating the Sustainable Facility Management-enhanced BIM Model. The method presented by Loeh et al. (2021) is modified by integrating BUILDER SMS parameters and naming conventions into the BIM model during, as opposed to after, the creation of the model. Four building models created in 2020-21, four from 2021-22, and one building from 2019 were used in this study. Two groups of students were used to evaluate the effect of the building-specific BIM templates. Evaluating the 2020 and …

The Stockholm Paradigm Explains The Dynamics Of Darwin’S Entangled Bank, Including Emerging Infectious Disease, Salvatore J. Agosta

MANTER: Journal of Parasite Biodiversity

Pathogens and their hosts are embedded within the larger biosphere, what Darwin called the “entangled bank.” Emerging infectious disease occurs when a parasite “switches” to a new host. Understanding the dynamics of emerging disease requires understanding the dynamics of host-switching, which requires a more general understanding of how the biosphere and its constituent members cope when conditions change. The Stockholm paradigm is an integrative evolutionary framework that describes how living systems cope with change by oscillating between exploiting and exploring the geographical and functional dimensions of their environments. It combines organismal capacity, ecological opportunity, and the repeated external perturbations to …

Design, Concept, And Visualization Of Urban Multi-Level Growing Table Systems In Hyper Urban Areas, Aaryan Manoj Nair, Shaheed Mohammed, Omar Rahama

Publications and Research

As of a 2019 study conducted by the National Urban Gardening Program (National Urban Gardening Program), urban farming accounts for approximately 19% of the total national farming output and is expected to triple to almost 45% by 2025. There is intensive research being conducted on aspects of reduced recidivism, communal health benefits, natural carbon capture systems, improved urban ecology and the necessity for reducing the carbon footprint of food, (informally dubbed “food miles”) there is little substantive research on optimisation, and maximation of crop productivity in hyper-urban areas.

The purpose of this report is to understand the functionalities of urban …

The Role Of Er Stress In Diabetes: Exploring Pathological Mechanisms Using Wolfram Syndrome, Shuntaro Morikawa, Fumihiko Urano

2020-Current year OA Pubs

The endoplasmic reticulum (ER) is a cytosolic organelle that plays an essential role in the folding and processing of new secretory proteins, including insulin. The pathogenesis of diabetes, a group of metabolic disorders caused by dysfunctional insulin secretion (Type 1 diabetes, T1DM) or insulin sensitivity (Type 2 diabetes, T2DM), is known to involve the excess accumulation of "poorly folded proteins", namely, the induction of pathogenic ER stress in pancreatic β-cells. ER stress is known to contribute to the dysfunction of the insulin-producing pancreatic β-cells. T1DM and T2DM are multifactorial diseases, especially T2DM; both environmental and genetic factors are involved in …

Associations Between Mental Health And Hiv Status Among Sexual Minority And Heterosexual Adolescents In Nigeria, Morenike Oluwatoyin Folayan, Olakunle Oginni, Olanrewaju Ibikunle Ibigbami, Uma Philip, Nserd Ntonoba Mfam, Chinedu Mbam, Amos Ganyam, Agada A Salem, Christopher Osuji, Cory Bradley, Joanne Lusher, Nadia Adjoa Sam-Agudu

2020-Current year OA Pubs

BACKGROUND: We aimed to determine associations between the mental health status of adolescents by self-reported sexual identity; and to determine associations between the mental health status of sexual minority adolescents living with and without HIV.

METHODS: This cross-sectional study collected data from Nigerians aged 13-19 years old using an online survey. We collected information on dependent (sexual identity) and independent (presence of depressive symptoms, generalised anxiety disorder, suicidal attempt/ideation, HIV status) study variables. A multivariate regression model determined associations between the dependent and independent variables. A second multivariate regression model was developed to establish associations between HIV status among sexual …

In Silico Activity And Admet Profiling Of Phytochemicals From Ethiopian Indigenous Aloes Using Pharmacophore Models, Lemessa Etana Bultum, Gemechu Bekele Tolossa, Gwangmin Kim, Ohhyeon Kwon, Doheon Lee

2020-Current year OA Pubs

In silico profiling is used in identification of active compounds and guide rational use of traditional medicines. Previous studies on Ethiopian indigenous aloes focused on documentation of phytochemical compositions and traditional uses. In this study, ADMET and drug-likeness properties of phytochemicals from Ethiopian indigenous aloes were evaluated, and pharmacophore-based profiling was done using Discovery Studio to predict therapeutic targets. The targets were examined using KEGG pathway, gene ontology and network analysis. Using random-walk with restart algorithm, network propagation was performed in CODA network to find diseases associated with the targets. As a result, 82 human targets were predicted and found …

Cuidado De La Vida, Un Reto Para El Mundo: Investigaciones Y Experiencias En Salud Publica, Sandra Patricia Carmona Urueña, María Nieves Ávila Ávila, Claudia Del Rocio Contreras Rodríguez, Olga Montiagudo Piqueras, Yolanda Bermúdez Niño, Tatiana Carolina Cantor Caicedo, Yensy Katherine Dimaté Villalobos, Danna Garnica Navarro, Shanda Demorest, María Victoria Rojas Martínez, Daniel Esteban Niño Moreno, Lina María Moreno Rubiano, Anyi Tatiana Rondón Barreto, Marcela Alejandra Bermúdez Valdés, Flor Alba Martínez Pinzón, Marcela Tamayo Ortiz

Ciencias de la Salud

El marco sanitario de España está determinado por la Ley General de Sanidad (lgs), Ley 14/1986, en la que el primer principio general estipula que: “Los medios y actuaciones del sistema sa nitario estarán orientados prioritariamente a la promoción de la salud ya la prevención de las enfermedades” (25 de abril de 1986). Ello supone una concepción integral de la salud, por lo que estos servicios han de incorporar las acciones de promoción de la misma y de prevención de las enfermedades, de igual modo que de las asistenciales, las curativas, las rehabilitadoras o los cuidados paliativos. . Así mismo, …

Factors Associated With Improved Outcome Of Inhaled Corticosteroid Use In Covid-19: A Single Institutional Study, A. Manfra, Claire Chen, Kavita Batra, Kyaw Min Tun, Mutsumi Kioka

Department of Internal Medicine Faculty Research

Asthmatics seem less prone to adverse outcomes in coronavirus disease 2019 (COVID-19) and some data shows that inhaled corticosteroids (ICS) are protective. We gathered data on anecdotal ICS and outcomes of patients hospitalized with COVID-19, given there is literature supporting ICS may reduce risk of severe infection. In addition, we fill gaps in current literature evaluating Charlson Comorbidity Index (CCI) as a risk assessment tool for COVID-19. This was a single-center, retrospective study designed and conducted to identify factors associated intubation and inpatient mortality. A multivariate logistic regression model was fit to generate adjusted odds ratios (OR). Intubation was associated …

Late Descemet Membrane Detachment After Uneventful Cataract Surgery, Lovaglio Cançado Trindade, Renata Attanasio De Rezende, Tiago Bisol, Christopher J Rapuano

Wills Eye Hospital Papers

Purpose: To report 5 patients with late Descemet membrane (DM) detachment after uneventful cataract surgery.

Observations: After a retrospective chart analysis of consecutive patients that developed DM detachment after uneventful cataract surgery, six eyes of five patients were enrolled. In all cases, patients reported good vision initially after cataract surgery. Within days to months, these patients developed late DM detachment with decreased vision. In one patient, the detachment affected both eyes. Filtered air or diluted sulfur hexafluoride were injected in the anterior chamber to tamponade the DM detachment. In five eyes, the cornea cleared after DM reattachment. In two eyes …

Mrs Alma Rita Youmans

African American Funeral Programs

Mrs_Alma_Rita_Youmans,pdf - Funeral program for Mrs. Alma Rita Youmans

Collaborative Interprofessional Health Science Student Led Realistic Mass Casualty Incident Simulation, Deborah L Mccrea, Robert C Coghlan, Tiffany Champagne-Langabeer, Stanley Cron

Faculty, Staff and Student Publications

In collaboration, a health science university and a fire department offered a mass casualty incident (MCI) simulation. The purpose of this study was to evaluate a cross-section of student health care providers to determine their working knowledge of an MCI. Students were given a pretest using the Emergency Preparedness Information Questionnaire (EPIQ) and the Simple Triage and Rapid Transport (START) Quiz. The EPIQ instrument related to knowledge of triage, first aid, bio-agent detection, critical reporting, incident command, isolation/quarantine/decontamination, psychological issues, epidemiology, and communications. The START Quiz gave 10 scenarios. Didactic online content was given followed by the simulation a few …

The Effect Of Seagrass Components On The Associated Bacterial Diversity And Antimicrobial Activity In Zostera Marina, Caroline Millan

The Plymouth Student Scientist

Seagrasses are marine angiosperms located in intertidal and sub-tidal waters. They are important ecosystem engineers that play a crucial role in the structure of habitats, allowing them to support a comprehensive diversity of life. Through fundamental ecological processes and the generation of niches, each seagrass species has aggregated an associated microbiome that lives among the various seagrass components and exhibit symbiotic relations. There have been studies investigating the diversity of the associated bacteria and elements of the resulting microbial activity, however these have primarily focused on tropical seagrass species and have failed to examine the extent of this bioactivity. This …

Age Differences In Facial First Impressions Of Traits Associated With Trustworthiness, Gulbeyaz Altun

The Plymouth Student Scientist

Older adults are more susceptible to becoming fraud victims due to increased generalised trust in others for assistance, leading to deception. Age differences in first impressions of unfamiliar faces on traits associated with trustworthiness was explored in this study. Investigating the various interpretations of trustworthiness across age has not been previously led. Using a data-driven approach, the key traits interpreted from trustworthiness were used in a trait rating task. Older adults provided higher ratings and showed an own-age bias for the traits trustworthy, honest, reliable, and loyal compared to younger adults, but not for the trait considerate. Mean trait ratings …

Investigating The Impacts Of Heterotrophic Nutrition On Acropora Microclados, Heather O'Keefe

The Plymouth Student Scientist

The Scleractinian coral Acropora microclados is a commercially important species that functions as both an autotroph and heterotroph. In ex situ coral aquaculture, elucidating an optimal diet to improve growth and resilience is critical in improving the sustainability and success of rearing corals for trade and conservation. To investigate the impacts of diet on A. microclados, three groups of 15 nubbins were kept under three different feeding regimes for three months at the National Marine Aquarium, Plymouth, UK. One group was fed nothing, the control (CTL), one group fed Artemia salina nauplii (ART) and one group fed a mixed diet …

An Investigation Into The Effects Of Weekly Habitual And Targeted Caffeine Consumption On Adult Runners' Endurance, Speed, And Mood, Elise Lucas

The Plymouth Student Scientist

BACKGROUND: Caffeine is a commonly consumed recreational drug which is also highly regarded as an ergogenic aid. Generally, users partake in sporadic and habitual caffeine consumption for functional benefits such as alertness or for social purposes, but targeted consumption prior to exercise is claimed to aid endurance, increase speed, and improve mood during exercise. OBJECTIVES: This questionnaire-based study aimed to evaluate the effect of targeted and randomised caffeine consumption on endurance, speed, and perceived mood in runners of varying levels. SUBJECTS: 489 subjects from 27 different countries (predominantly United States of America and United Kingdom) participated in the study (50.7% …

Reasons For Living Following An Acquired Brain Injury: A Mixed Thematic Analysis, Catalana Parris

The Plymouth Student Scientist

Considering the prevalence of acquired brain injury (ABI) and the concerning statistics around the associated risk of problematic substance use, impacted mental health, and suicidality (3-4 greater risk of suicidality in those with TBI), and the lack of qualitative, recent, and UK based research. This study aimed to explore what people’s reasons for living after ABI were. Individuals living with ABI were recruited via BABICM (British Association of Brain Injury and Complex Case Management) to participate in semi-structured interviews. A mixed thematic analysis was conducted on the transcripts using the themes from Knight, Norman and Simpson (2020) as a framework …

Marine Mammals In The Western English Channel, A Survey From The Rame Head Peninsula, Janine Douglas

The Plymouth Student Scientist

This paper presents the first records of marine mammals in Plymouth Sound National Marine Park (NMP), and over 1000 individual animal observations were recorded. Marine mammal temporal and spatial distributions were quantified for the first time at Rame Head, a vantage point overlooking the NMP and the Western English Channel. A biodiversity hotspot, the Western English Channel supports many species of marine mammals, yet it is subject to increasing anthropogenic pressures, such as heavy shipping, which could significantly impact populations. Whilst marine mammals are well studied, their distributions and population sizes remain largely unknown; effective conservation of these animals requires …

Bankruptcy Basics: What The U.S. Can Learn From The U.K. Filing Processes, Courtney Kobren

Duke Journal of Comparative & International Law

Although filing for bankruptcy is the primary form of economic relief for U.S. consumers in financial distress, pro se debtors lack access to the consumer bankruptcy system. An individual debtor faces many challenges when filing for bankruptcy without an attorney, since the debtor must rely on free access to the information provided by the U.S. Courts website. However, that information is vague and presented in complex legalese and dissuasive diction. On the other hand, U.K. debtors who need financial relief can file for bankruptcy through a clear and accessible bankruptcy filing process. U.K. debtors also have access to free consumer …

Machine Learning Of Plasma Metabolome Identifies Biomarker Panels For Metabolic Syndrome: Findings From The China Suboptimal Health Cohort, Hao Wang, Youxin Wang, Xingang Li, Xuan Deng, Yuanyuan Kong, Wei Wang, Yong Zhou

Research outputs 2022 to 2026

Background: Metabolic syndrome (MetS) has been proposed as a clinically identifiable high-risk state for the prediction and prevention of cardiovascular diseases and type 2 diabetes mellitus. As a promising “omics” technology, metabolomics provides an innovative strategy to gain a deeper understanding of the pathophysiology of MetS. The study aimed to systematically investigate the metabolic alterations in MetS and identify biomarker panels for the identification of MetS using machine learning methods. Methods: Nuclear magnetic resonance-based untargeted metabolomics analysis was performed on 1011 plasma samples (205 MetS patients and 806 healthy controls). Univariate and multivariate analyses were applied to identify metabolic biomarkers …

Risk Factors For Sars-Cov-2 Transmission In Close Contacts Of Adults At High Risk Of Infection Due To Occupation: Results From The Contact Tracing Strategy Of The Covida Epidemiological Surveillance Study In Bogotá, Colombia, In 2020-2021, Andrea Ramírez Varela, Sandra Contreras-Arrieta, Guillermo Tamayo-Cabeza, Leonardo Salas Zapata, Yuldor Caballero-Díaz, Luis Jorge Hernández Florez, Andrés Patiño Benavidez, Rachid Laajaj, Fernando De La Hoz, Giancarlo Buitrago Gutierrez, Silvia Restrepo, Eduardo Behrentz

Faculty, Staff and Student Publications

OBJECTIVES: To estimate the risk factors for SARS-CoV-2 transmission in close contacts of adults at high risk of infection due to occupation, participants of the CoVIDA study, in Bogotá D.C., Colombia.

SETTING: The CoVIDA study was the largest COVID-19 intensified sentinel epidemiological surveillance study in Colombia thus far, performing over 60 000 RT-PCR tests for SARS-CoV-2 infection. The study implemented a contact tracing strategy (via telephone call) to support traditional surveillance actions performed by the local health authority.

PARTICIPANTS: Close contacts of participants from the CoVIDA study.

PRIMARY AND SECONDARY OUTCOME MEASURES: SARS-CoV-2 testing results were obtained (RT-PCR with CoVIDA …