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Danio Rerio: A Past, Present, And Future Hallmark For Immunological Studies, Michael Solomon Chembars Jr.

Senior Honors Theses

An emerging species that is slowly gaining reputation as a common model organism is Danio rerio. Due to its similarities to our own immune response and its general ease of use, hundreds of studies have been conducted which have increased our understanding of how chemicals or pathogens can affect both our own health, and the health of the environment.

This study aims to briefly describe a brief history of D. rerio, as well as discuss key experiments that have been performed using D. rerio. A comparison will also be made between the human and zebrafish immune responses, and …

Comments On The International Criminal Court Office Of The Prosecutor's Draft Policy On The Crime Of Gender Persecution Under The Rome Statute, Milena Sterio

Law Faculty Reports and Comments

The Draft Policy promises to be a seminal contribution not only to the Office of the Prosecutor's (OTP) policy and practice and the International Criminal Court's (ICC) jurisprudence on gender persecution, but also to the development of international criminal law generally. Building on its prior work, including the 2014 Policy Paper, the OTP is well placed to develop policies and procedures that protect historically marginalized and oppressed groups, deliver justice that accurately reflects the depth and breadth of the gender persecution suffered, and shed light on a crime that has to date received only limited attention.

As it finalizes the …

Do Prison Conditions Change How Much Punishment A Sentence Carries Out? Lessons From Federal Sentence Reduction Rulings During The Covid-19 Pandemic, Skylar Albertson

Northwestern Journal of Law & Social Policy

A set of motions filed during the COVID-19 pandemic challenged federal judges to consider whether they should always view the duration of imprisonment—as contrasted with prison conditions—as the sole determinant of how much punishment a sentence carries out. Under 18 U.S.C § 3582(c)(1)(A)(i), federal judges may “reduce” already imposed terms of imprisonment upon finding that “extraordinary and compelling reasons” warrant reductions. Prior to 2019, the Bureau of Prisons (BOP) effectively controlled the scope of a catch-all subcategory of “Other Reasons” justifying sentence reductions. The BOP used this authority almost exclusively for people who were in the final stages of terminal …

Prosthetic Management Of Interruptive Mandibular Defects, Saloua Hamzaoui, Mohamed Azhari, Hasnaa Rokhssi, Majid Sakout, Oussama Bentahar

International Arab Journal of Dentistry

Mandibular substance loss is one of the most frequent acquired defects of the maxillofacial mass. Several etiologies have been described, the most frequent of which are tumours and traumas. The most commonly used prosthetic classification takes into consideration the bone continuity of the mandible, thus there are marginal defect mandibular substance preserving bone continuity and segmental defect with basal bone discontinuity. These bone defects lead to numerous functional complications (loss the dental occlusion, decreased chewing efficiency, lack of stalling during swallowing, phonatory disorder related to the change in the buccal resonance cavity) and aesthetic complications (facial asymmetry due to lateral …

Practical Mouse Model To Investigate Therapeutics For Staphylococcus Aureus Contaminated Surgical Mesh Implants, Madison M. Collins, Brent Race, Ronald J. Messer, Chase Baune, Scott D. Kobayashi, Dan Long, Katie Williams, Aaron M. Hasenkrug, Kim Hasenkrug, Natalia Malachowa

School of Medicine Faculty Publications

Introduction: The use of prosthetic mesh in hernia repair provides a powerful tool to increase repair longevity, decrease recurrence rates, and facilitate complex abdominal wall reconstruction. Overall infection rates with mesh are low, but for those affected there is high morbidity and economic cost. The availability of a practicable small animal model would be advantageous for the preclinical testing of prophylactics, therapeutics, and new biomaterials. To this end, we have developed a novel mouse model for implantation of methicillin-resistant Staphylococcus aureus–infected surgical mesh and provide results from antibiotic and immunotherapeutic testing. Materials and Methods: Implantation of surgical mesh between fascial …

Effects Of Glycerol Application Ratio On The Distribution Of Moisture, Nicotine And Glycerol In Heated Cigarettes, Zhu Longjie, Zhang Yuan, Cao Yi, Qin Yanhua, Liu Mengmeng, Zhu Huaiyuan

Food and Machinery

Objective:In order to optimize the process parameters of tobacco sheet of heated cigarette. Methods:12 gradient grades of tobacco sheets with glycerol addition ratio of 5%~30% were prepared under laboratory conditions. The mass of moisture, nicotine and glycerol in heated cigarette smoke, filter condensation section and tobacco core section were detected by GC-TCD method. And the mass distribution characteristics of main components, release rate, filtration rate and transfer rate were analyzed. Results:When 5%~30% glycerol was applied to the heated cigarette tobacco sheets, the water release rate was 88.6%~92.3%, which was mainly distributed in the smoke and filter condensation …

Visualization Of Lamb Adulteration Based On Hyperspectral Imaging For Non-Destructive Quantitative Detection, Zhao Jing-Yuan, Zhang Jun-Qin, Sun Mei, Chen Xing-Hai, Liu Ye-Lin

Food and Machinery

Objective: This study aimed to establisha rapid and accurate prediction method of lamb adulteration by using visible/near-infrared (400~1 000 nm) and short-wave near-infrared (900~1 700 nm) hyperspectral imaging techniques.Methods: The data acquisition of lamb adulterated with different proportions of duck meat using visible/near-infrared (400~1 000 nm) and short-wave near-infrared (900~1 700 nm) hyperspectral imagers was performed to compare the effect of partial least squares (PLS) modeling with different spectral preprocessing methods in the two band ranges. Then the normalized preprocessing method was selected in the visible-NIR band, and the standard normal variate transformation (SNV) preprocessing method was …

Protective Effects Of The Pea Ace Inhibitory Peptide On Induced Damage Of Ea.Hy.926 Cells, Zhang Shuo, Zheng Xiqun, Liu Xiaolan, Wang Juntong

Food and Machinery

Objective:This study aimed to realize the high-value utilization of pea protein.Methods:Using pea protein as raw material, ACE inhibitory peptide derived from pea protein was prepared by double-enzyme coordinated enzymatic hydrolysis method, and the ACE inhibition rate, hydrolysis degree and soluble protein content of the hydrolysate were used as indicators to determine the best enzymatic process for the pea ACE inhibitory peptide. Then the ACE inhibitory peptides produced under the optimal enzymatic digestion process were graded by ultrafiltration to explore the effect of molecular weight on the ACE inhibitory activity. Finally, the protective effect of the pea peptide with high ACE …

Optimization Of Puffing Process Of Blueberry Residue Composite Indica Rice And Its Antioxidant Activity, Zhang Xinzhen, Yang Tao, Jiang Yiting, Ju Feilong, Gao Yang, Sun, Li Xueling, Liang Jin

Food and Machinery

Objective: This study aimed to research and develop puffed blueberry dregs indica rice and fruit snack food. Methods: Using indica rice flour and blueberry residue powder as raw materials, three experimental factors including moisture content, extrusion temperature and screw speed were selected, and the expansion degree, anthocyanin content and sensory score were taken as comprehensive indexes. The expansion process was optimized by single factor and orthogonal test, and the antioxidant activity of the expanded products was studied. Results: The optimum process parameters were as follows: the moisture content of the material was 16%, the temperature of the …

Interactions Between Food Polyphenols And Proteins And Their Effects On Protein Characteristics, Xu Mengting, Hao Yanbin, Qi Jianxun, Ding Baomiao, Chen Yonghao

Food and Machinery

This paper summarizes the research progress on the types of interactions between proteins and polyphenols and their effects on protein characteristics, and prospects the future foods with the coexistence of polyphenols and proteins.

Multilevel Correlates Of Domain-Specific Physical Activity Among Rural Adults - A Cross-Sectional Study, Alan M Beck, Natalicio H Serrano, Audrey Toler, Ross C Brownson

2020-Current year OA Pubs

BACKGROUND: Increasing physical activity (PA) in rural communities is a vital prevention tactic in multiple chronic diseases; however, little is known on the multilevel correlates of PA rural areas. A better understanding of domain-specific PA adds context for promoting PA in rural communities. The current study sought to determine factors associated with domain-specific and overall moderate-vigorous physical activity (MVPA) in rural communities.

METHODS: Surveys were conducted across 14 rural mid-Western communities, with the final analytical sample including 1241 adults (ages 19-96, M = 57.0 [SD = 16.7], 67.8% female, 83.8% white). Generalized linear models with negative binomial distributions examined the …

Muscle-Specific Ablation Of Glucose Transporter 1 (Glut1) Does Not Impair Basal Or Overload-Stimulated Skeletal Muscle Glucose Uptake, Shawna L Mcmillin, Parker L Evans, William M Taylor, Luke A Weyrauch, Tyler J Sermersheim, Steven S Welc, Monique R Heitmeier, Richard C Hresko, Paul W Hruz, Francoise Koumanov, Geoffrey D Holman, E Dale Abel, Carol A Witczak

2020-Current year OA Pubs

Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 levels. The primary objective of this study was to determine if GLUT1 is necessary for basal or overload-stimulated muscle glucose uptake. Muscle-specific GLUT1 knockout (mGLUT1KO) mice were generated and examined for changes in body weight, body composition, metabolism, systemic glucose regulation, muscle glucose transporters, and muscle [

Charles Boykins Iii, Oral History Interview, 2022, Kennedi Boler

COVID-19 Oral Histories

In October and November of 2022, You Li's Journalism 313 students conducted oral history interviews with one another to document the student experience of the COVID-19 pandemic. In this interview, EMU undergraduate Charles Boykins III describes the early days of COVID, and mental health.

Kennedi Boler, Oral History Interview, 2022, Charles Boykins Iii

COVID-19 Oral Histories

In October and November of 2022, You Li's Journalism 313 students conducted oral history interviews with one another to document the student experience of the COVID-19 pandemic. In this interview, EMU undergraduate Kennedi Boler talks about mental health during the early days of COVID, and moving forward in the future.

Urban Health: A Practical Application For Clinical Based Learning, Cynthera Mcneill, Umeika Stephens, Tara Walker

Open Textbooks

Urban Health: A Practical Application for Clinical Based Learning is an openly licensed, peer-reviewed textbook for clinical-based nursing educators covering barriers in urban health and their impact on patient health outcomes. The authors explore perspectives of urban communities, urban patients, and urban healthcare providers to offer insight into how healthcare providers can address disparities in urban healthcare, provide meaningful care with the lived experiences of urban patients in mind, and improve patient-provider communication by moving towards a more solution-driven, team-based care approach. Features include learning activities, exemplars, and case studies.

Financial Well-Being Of Frontline Healthcare Workers: The Importance Of Employer Benefits, Mathieu Despard, Sophia Fox-Dichter, Haotian Zheng, Grace Anderson, Olivia Borland, Kourtney Gilbert

Social Policy Institute Research

Frontline healthcare workers – especially direct care workers (DCWs), such as home health aides, struggle due to low pay, lack of benefits, and difficult working conditions. The need for these workers is growing. Unless frontline healthcare jobs improve, positions may be difficult to fill, and care for vulnerable members of society may be compromised.

In this study, we surveyed 2,321 frontline healthcare workers and conducted in-depth interviews with 30 of these workers concerning pay, benefits, work conditions, and financial well-being. Key survey findings included:

• Only 39% of workers were eligible for at least four out of five major benefits (e.g., …

Tonsillectomy In Children With 22q11.2 Deletion Syndrome., Jill M. Arganbright, Paul Bryan Hankey, Meghan Tracy, Srivats Narayanan, Janelle R. Noel-Macdonnell Phd, David G. Ingram Md

Manuscripts, Articles, Book Chapters and Other Papers

Tonsillectomy is one of the most common procedures performed in children, however there are currently no published studies evaluating tonsillectomy in children with 22q11.2 deletion syndrome (22q11DS). With this study, our goal was to investigate the indications, efficacy, and complications of tonsillectomy in a pediatric cohort of patients with 22q11DS. This is a retrospective chart review of patients in our 22q Center's repository. Inclusion criteria were a diagnosis of 22q11DS and a history of tonsillectomy or adenotonsillectomy. Data collected included: indications for tonsillectomy, preoperative and postoperative polysomnography (PSG) results, and surgical complications. In total, 33 patients were included. Most common …

Person-Centredness In The Workplace: An Examination Of Person-Centred Skills, Processes And Workplace Factors Among Medicaid Waiver Providers In The United States, Bret J. Blackmon, Joohee Lee, Rebecca Bain, B. Michelle Brazeal, Courtney Williams, Yolanda Green

Faculty Publications

Background: Existing research supports the effectiveness of person-centred practices in working with persons with physical, intellectual and developmental disabilities, but less clear is the influence of workplace factors on the implementation and quality of person-centred practices.

Aims: This article explores the influence of workplace factors on job satisfaction and on the implementation and quality of person-centred practices in healthcare agencies that provide home- and community-based services through a Medicaid waiver in Mississippi, a state in the southeastern United States.

Methods: Purposive sampling was used to collect data via online surveys to explore the interrelationships among person-centred workplaces, job satisfaction …

Top Croft Students Awarded Scholarships, Erin Garrett

University of Mississippi News

Institute celebrates 25 years of supporting international studies majors

Medication Adherence And People Living With Hiv: A Qualitative Study, Lisa L. Dale

Electronic Theses and Dissertations Archive

Abstract While significant strides have developed evidence-based preventions and treatments for people living with HIV/AIDS (PLWHA), only 26% percent of HIV-positive people in care achieve the treatment objective of viral suppression (Viral Suppression, 2018). While the literature has identified a positive relationship between patient-provider communication and optimum treatment adherence, nonadherence is poorly understood, and no evidence-based model for such communication exists. This study aims to examine the perspectives of HIV-positive patients and family/friend caregivers (FFC) related to treatment adherence, as most of the literature has been dominated by the clinician’s point of view. Further, this work seeks to provide knowledge …

The Antimicrobial Resistance Crisis Needs Action Now, Nonia Pariente

Research on Antimicrobial Resistance

Antimicrobial resistance is a global problem of increasing proportions that we cannot afford to look away from. This World Antimicrobial Awareness Week, we shine a light on the crisis and ways we can all help to address it.

Methylone And Mdma Pharmacokinetics Following Controlled Administration In Humans, Lourdes Poyatos, Alfredo Fabrizio Lo Faro, Diletta Berardinelli, Giorgia Sprega, Sara Malaca, Simona Pichini, Marilyn A. Huestis, Esther Papaseit, Clara Pérez-Mañá, Francesco Paolo Busardò, Magí Farré

Institute of Emerging Health Professions Faculty Papers

The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. The study was a randomized, cross-over, double-blinded and placebo-controlled study, with a total of 468 plasma samples collected. First, 10 µL of MDMA-d5, MDA-d5 and methylone-d3 internal standards were added to 100 µL of plasma. Two mL of chloroform and ethyl acetate 9:1 (v/v) were then added, mixed well and centrifuged. The supernatant was fortified with …

Single Nuclei Analyses Reveal Transcriptional Profiles And Marker Genes For Diverse Supraspinal Populations, Zachary Beine, Zimei Wang, Pantelis Tsoulfas, Murray G. Blackmore

Biomedical Sciences Faculty Research and Publications

The mammalian brain contains numerous neurons distributed across forebrain, midbrain, and hindbrain that project axons to the lower spinal cord and work in concert to control movement and achieve homeostasis. Extensive work has mapped the anatomic location of supraspinal cell types and continues to establish specific physiological functions. The patterns of gene expression that typify and distinguish these disparate populations, however, are mostly unknown. Here, using adult mice of mixed sex, we combined retrograde labeling of supraspinal cell nuclei with fluorescence-activated nuclei sorting and single-nuclei RNA sequencing analyses to transcriptionally profile neurons that project axons from the brain to lumbar …

Myocardial Strain Imaging In Duchenne Muscular Dystrophy, Conner C. Earl, Jonathan Soslow, Larry W. Markham, Craig J. Goergen

Purdue University Libraries Open Access Publishing Fund

Cardiomyopathy (CM) is the leading cause of death for individuals with Duchenne muscular dystrophy (DMD). While DMD CM progresses rapidly and fatally for some in teenage years, others can live relatively symptom-free into their thirties or forties. Because CM progression is variable, there is a critical need for biomarkers to detect early onset and rapid progression. Despite recent advances in imaging and analysis, there are still no reliable methods to detect the onset or progression rate of DMD CM. Cardiac strain imaging is a promising technique that has proven valuable in DMD CM assessment, though much more work has been …

December 1, 2022: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the December 1, 2022, meeting of the University Senate. 26 pages

Effects Of Slightly Acidic Electrolytic Water On Blueberry Sterilization Process And Storage Quality, Huang Liping, Jin Xueyuan, Li Yong, Xue Jing

Food and Machinery

Objective:To improve the preservation quality of blueberry.Methods:Based on the influencing factors of the effective chlorine concentration, treatment temperature and soaking time of the SAEW, and the response value of the microbial sterilization rate on the surface of blueberries, the orthogonal test was used to optimize the process conditions. At the same time, the optimally treated blueberries and sterile water-treated blueberries (control group) were stored at (25±1) ℃, and the bad fruit rate, hardness, respiration strength, soluble solids content, titratable acid content, anthocyanin content, and malondialdehyde (MDA) content of blueberries were measured every 7 days.Results:The optimal …

Editorial, Prof. Elie Khoury

International Arab Journal of Dentistry

No abstract provided.

Factors Influencing The Decision To Initiate Orthodontic Treatment And The Choice Of Appliance Type In A Lebanese Sample During The Covid-19 Pandemic And The Economic Crisis. A Cross-Sectional Study., Liliane Alameh, Elie Khoury, Elie Amm

International Arab Journal of Dentistry

Background: The spread of Coronavirus Disease 2019 (COVID-19) has led to a major public health issue. This study aimed to assess the factors that influence the Lebanese people in undergoing an orthodontic treatment after the outbreak of COVID-19, as well as the factors that influence their choice of orthodontic appliance type. Methods: 489 Lebanese participants (199 men and 290 women) were invited to fill a questionnaire developed on Google Forms. Eligible participants were simply Lebanese people including those who immigrated during the crisis. Dentists, dental students and foreigners were excluded from the study. The link for the questionnaire was sent …

Effect Of Impression Techniques On Soft Tissue Vertical Displacement In Removable Partial Denture. A Pilot Study, Christine Hanna, Nada El Osta, Jihad Fakhouri

International Arab Journal of Dentistry

Abstract Purpose: The purpose of this study was to evaluate the vertical displacement of soft tissue during different impression procedures using various spacing of the custom tray, and to determine which impression technique would allow the minimal movement. Material and Methods: 21 partially edentulous subjects were selected and enrolled in the study. Each one of them was subjected to four different impression procedures: three alginate impressions with different spacing of the custom tray and one composed with different impression materials, then casts were constructed. Light-curing acrylic occlusal platform was constructed on the primary model and perforated in 10 different points. …

Therapeutic Management Of A Case Of Chronic Myofacial Pain, Anissa Abdelkoui, Jihane Elaoud, Ahmed Abdedine, Nadia Merzouk

International Arab Journal of Dentistry

Myofacial pain is a common form of temporomandibular disorders. It is manifested by a sensory, motor and autonomous symptoms caused by trigger points. These pains can significantly affect patients’ quality of life, when they persist. Several etiological factors have been implicated in the genesis of the myofacial pain: muscle overload, emotional tension, harmful postural habits, fatigue, and hypovitaminosis... The diagnosis of myofacial pain is based on a pertinent history and clinical examination. Several therapeutic options alone or in combination have proven their effectiveness. This article aims, through a clinical case, to focus on myofacial pain, possible therapeutics, by focusing on …