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Articles 5251 - 5280 of 76545
Full-Text Articles in Entire DC Network
Using Foundation Capital For Good: Opportunities In The Balance Sheet, John Sherman, Veronica Olazabal
Using Foundation Capital For Good: Opportunities In The Balance Sheet, John Sherman, Veronica Olazabal
The Foundation Review
Foundations increasingly use their full balance sheets to unlock more of their capital for good. They look beyond conventional grantmaking to pursue their charitable purposes in many ways that exemplify innovative, full-balance sheet approaches: investing in nonprofit and for-profit companies that offer clear social and financial returns; investing their corpus in companies whose products and services align with their missions; using social bonds to inject new resources into their programs; offering guarantees to help grantees manage risk; and avoiding companies whose practices run counter to their grantees’ efforts.
This article looks at the structures, pathways, and tools for foundations wanting …
Defining Your Double Bottom Line: Philanthropy And The Investment Landscape, Stephane Ligonde, Garrett De Temple, Tuokpe Ajuyah
Defining Your Double Bottom Line: Philanthropy And The Investment Landscape, Stephane Ligonde, Garrett De Temple, Tuokpe Ajuyah
The Foundation Review
Grantmaking traditionally has been at the heart of philanthropy, whereas impact was the exclusive expectation of any desired result. While there is still a place for this kind of pure push for change, many investors today expect more, leveraging the power of the markets to invest in a way that is both impactful and able to maximize their financial rewards. This is particularly true of foundations with an eye toward supporting the perpetuity of their missions and organizations.
This approach also offers a range of innovative mission-based benefits, including extending the utility of philanthropic capital and generating more capital to …
Donor-Advised Funds And Impact Investing: A Practitioner’S View, Sam Marks
Donor-Advised Funds And Impact Investing: A Practitioner’S View, Sam Marks
The Foundation Review
Any discussion of foundations embracing impact investing must include some discussion of one of the largest — and growing — sources of philanthropic capital: donor-advised funds. These philanthropic accounts allow donors of all sizes to access many of the functions of a private foundation, including the potential to invest for impact. Sponsors of these funds, however, face unique challenges in catalyzing impact investments.
Like the larger institutional foundations that have led the way as mission investors, sponsors must often educate and inspire governance boards and investment committees. Unlike foundations with professional program staff, decisions regarding philanthropic resources at sponsors of …
Sustainability Hub Newsletter - December 2022, Jacqueline Jergensen, Neyda Gilman, Jennifer Embree
Sustainability Hub Newsletter - December 2022, Jacqueline Jergensen, Neyda Gilman, Jennifer Embree
Library Sustainability Resources
In our last issue of the year, read about how to get involved with sustainability focused student groups, the Reclaiming Turtle Island documentary featuring a local activist, food resources on campus, the Move Out Spring Internship, sustainable holiday tips, and other announcements!
Urbanization Of Aedes Mosquito Populations And Evolution Of Arboviral Disease Risk In Africa, Sheila B. Agha, David P. Tchouassi
Urbanization Of Aedes Mosquito Populations And Evolution Of Arboviral Disease Risk In Africa, Sheila B. Agha, David P. Tchouassi
All Peer-Reviewed Publications
The arboviral diseases dengue, chikungunya, and yellow fever are re-merging and gaining a foothold in Africa, with a significant threat of large outbreaks in urban areas. Although their emergence is intimately linked to the primary vector Aedes aegypti, which thrives in urban environments, the risk of these diseases remains substantially heterogeneous in different geographic areas. Range expansion of invasive mosquito species Aedes albopictus, and colonization of urban habitats by sylvatic and peridomestic Aedes vectors, are likely to alter the diseases’ epidemiology. We discuss how a network of different vector species and perhaps vector subpopulations could interact with associated serotypes/genotypes/lineages of …
Outdoor Malaria Vector Species Profile In Dryland Ecosystems Of Kenya, Fiona Kinya, Clifford M. Mutero, Rosemary Sang, Eunice A. Owino, Gilbert Rotich, Edwin O. Ogola, Charles S. Wondji, Baldwyn Torto, David P. Tchouassi
Outdoor Malaria Vector Species Profile In Dryland Ecosystems Of Kenya, Fiona Kinya, Clifford M. Mutero, Rosemary Sang, Eunice A. Owino, Gilbert Rotich, Edwin O. Ogola, Charles S. Wondji, Baldwyn Torto, David P. Tchouassi
All Peer-Reviewed Publications
Outdoor biting by anopheline mosquitoes is one of the contributors to residual malaria transmission, but the profile of vectors driving this phenomenon is not well understood. Here, we studied the bionomics and genetically characterized populations of An. gambiae and An. funestus complexes trapped outdoors in three selected dryland areas including Kerio Valley, Nguruman and Rabai in Kenya. We observed a higher abundance of Anopheles funestus group members (n = 639, 90.6%) compared to those of the An. gambiae complex (n = 66, 9.4%) with An. longipalpis C as the dominant vector species with a Plasmodium falciparum sporozoite rate (Pfsp) of …
Beyond The Medication Pass: Attitudes, Ethics, Agency, And Antipsychotic Medications In Assisted Living/Residential Care, Sarah Dys, Paula Carder
Beyond The Medication Pass: Attitudes, Ethics, Agency, And Antipsychotic Medications In Assisted Living/Residential Care, Sarah Dys, Paula Carder
Institute on Aging Publications
Background and Objectives
As-needed (PRN) antipsychotic medication use (APU) among assisted living/residential care (AL/RC) residents is a controversial health policy issue. AL/RC care staff, families, clinicians, researchers, and policymakers disagree about PRN APU to manage behavioral expressions associated with residents’ dementia or cognitive impairment.
Research Design and Methods
Semistructured interviews among eleven direct care staff (n = 3), licensed nurses (n = 2), administrators/executive directors (n = 4), and consultant pharmacists (n = 2) currently working in Oregon AL/RC. Using situational analysis, we identify, describe, and visualize positions and ideologies by job role to theorize PRN …
Clinician’S Recommendations In Treating Victims And Survivors Of Narcissistic Abuse, Sadaf Shalchian
Clinician’S Recommendations In Treating Victims And Survivors Of Narcissistic Abuse, Sadaf Shalchian
Loma Linda University Electronic Theses, Dissertations & Projects
Although marriage and family therapists are one of the main providers in treating mental and relational health issues, there is not a significant emphasis on the identification, assessment, and treatment of victims and survivors of narcissistic abuse in COAMFTE-accredited Masters level Marriage and Family Therapy programs (COAMFTE, 2017). This needs assessment aimed to identify the knowledge and clinical skills recommended by clinicians who treat victims and survivors of narcissistic abuse to identify some needs, assessments, and treatment practices that can guide LMFTs in treating this population. This needs assessment explored current literature, research, and academic and clinical resources focused on …
Fabrication Of Electrospun Nanofibers Membrane For Emulsified Oil Removal From Oily Wastewater, Sura M. Alkarbouly, Basma I. Waisi
Fabrication Of Electrospun Nanofibers Membrane For Emulsified Oil Removal From Oily Wastewater, Sura M. Alkarbouly, Basma I. Waisi
Baghdad Science Journal
The electrospun nanofibers membranes have gained considerable interest in water filtration applications. In this work, the fabrication and characterization of the electrospun polyacrylonitrile-based nonwoven nanofibers membrane are reported. Then, the membrane's performance and antifouling properties were evaluated in removing emulsified oil using a cross flow filtration system. The membranes were fabricated with different polyacrylonitrile (PAN) concentrations (8, 11, and 14 wt. %) in N, N-Dimethylformamide (DMF) solvent resulted in various average fiber sizes, porosity, contact angle, permeability, oil rejection, and antifouling properties. Analyses of surface morphology of the fabricated membranes before and after oil removal revealed increasing the fiber size, …
Studying The Genotype Of Aryl Hydrocarbon Receptor-Interacting Protein (Aip) Gene (Rs641081c>A) In Iraqi Samples With Acromegaly Pituitary Adenoma, Yassamen Samer Abd Aon, Sanaa Jasim Kadhim, Abdilkarim Y. Al-Samarriae
Studying The Genotype Of Aryl Hydrocarbon Receptor-Interacting Protein (Aip) Gene (Rs641081c>A) In Iraqi Samples With Acromegaly Pituitary Adenoma, Yassamen Samer Abd Aon, Sanaa Jasim Kadhim, Abdilkarim Y. Al-Samarriae
Baghdad Science Journal
Pituitary adenomas are the anterior pituitary tumors.Patients with anAryl Hydrocarbon Receptor-Interacting Protein (AIP)mutation (AIP-mut) tend to have more aggressive tumors occurring at a younger age. Single nucleotide polymorphisms (SNPs) inmany studies have been related to metabolic comorbidities in the general population. Study aims investigated the role of AIPgene SNPs with susceptibility to acromegaly pituitary-adenoma, with levels of LH, FSH, TSH, Testosterone, IGF1,GH, FT4 , Prolactin hormones and blood sugar levels.The study was conducted on a group of acromegaly patients, including 50 patients) both Genders(with hyperplasia of the ends, andapparently healthy control group. Genotyping of AIP gene SNP (rs641081C >A) was …
Cytogenetic Investigations And Y-Chromosome Microdeletion Screening In Some Infertile Kurdish Males In Erbil Province/ Iraq, Muhsin Jamil Abdulwahid, Mustafa Saber Al-Attar, Rozhgar Abdullah Mohammed
Cytogenetic Investigations And Y-Chromosome Microdeletion Screening In Some Infertile Kurdish Males In Erbil Province/ Iraq, Muhsin Jamil Abdulwahid, Mustafa Saber Al-Attar, Rozhgar Abdullah Mohammed
Baghdad Science Journal
Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Worldwide, infertility affects approximately 15% of all couples trying to conceive. Male infertility is responsible for about 50% of the infertility cases. Chromosomal abnormalities and Y-chromosome microdeletions are the most common genetic causes of male infertility. Klinefelter syndrome (KS) is the most prevalent factor of the chromosomal abnormality in the infertile male. Azoospermia Factor (AZF) microdeletions located on the Y chromosome are one of the recurrent genetic cause of male infertility. This study …
New-Onset Psychosis Following Covid-19 Infection In A Patient With No Psychiatric History: A Longitudinal Case Report., Matthew Runyan, Jay Fawver, Amanda Coupe, Michelle Drouin
New-Onset Psychosis Following Covid-19 Infection In A Patient With No Psychiatric History: A Longitudinal Case Report., Matthew Runyan, Jay Fawver, Amanda Coupe, Michelle Drouin
Health Services and Informatics Research
BACKGROUND: Viral infection, including COVID-19, has been implicated as a potential cause of various neurobehavioral issues. An increasing number of case reports suggest that current or recent COVID-19 infection may cause new onset of psychotic symptoms in some individuals, potentially related to viral inflammation or infection of the nervous system.
CASE PRESENTATION: A 26-year-old woman with no psychiatric history presented with severe psychotic symptoms days after recovery from a mild COVID-19 infection. No other etiologies for psychosis were identified via diagnostic testing, review of medical history, or interviews with family. Her symptoms persisted for approximately two months, requiring three inpatient …
Simultaneous Ratio Derivative Spectrophotometric Determination Of Paracetamol, Caffeine And Ibuprofen In Their Ternary Form, Khalaf F. Alsamarrai, Suham Tawfeq Ameen
Simultaneous Ratio Derivative Spectrophotometric Determination Of Paracetamol, Caffeine And Ibuprofen In Their Ternary Form, Khalaf F. Alsamarrai, Suham Tawfeq Ameen
Baghdad Science Journal
A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and second ratio derivative spectrum using a double devisor. Par, Ibu, and Caf showed many useful peaks for their quantified determination. The validity of all analysis modes for determination of the three compounds, peak to baseline, peak area and peak to peak were according to ICH. The linearity of two methods was between 5 µg/ml as a lower concentration and 50 µg/ml as the highest concentration for three compounds. Recovery percentage was around 100% …
Predictive Significance Of Interleukins 17a And 33 In Risk Of Relapsing–Remitting Multiple Sclerosis, Milad Abdul Salam Al-Naseri, Ali Hussein Ad’Hiah, Ehab Dawood Salman
Predictive Significance Of Interleukins 17a And 33 In Risk Of Relapsing–Remitting Multiple Sclerosis, Milad Abdul Salam Al-Naseri, Ali Hussein Ad’Hiah, Ehab Dawood Salman
Baghdad Science Journal
Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± …
A Green Synthesis Of Iron/Copper Nanoparticles As A Catalytic Of Fenton-Like Reactions For Removal Of Orange G Dye, Ahmed K Hassan, Mohammed A Atiya, Imad M Luaibi
A Green Synthesis Of Iron/Copper Nanoparticles As A Catalytic Of Fenton-Like Reactions For Removal Of Orange G Dye, Ahmed K Hassan, Mohammed A Atiya, Imad M Luaibi
Baghdad Science Journal
This research paper studies the use of an environmentally and not expensive method to degrade Orange G dye (OG) from the aqueous solution, where the extract of ficus leaves has been used to fabricate the green bimetallic iron/copper nanoparticles (G-Fe/Cu-NPs). The fabricated G‑Fe/Cu-NPs were characterized utilizing scanning electron microscopy, BET, atomic force microscopy, energy dispersive spectroscopy, Fourier-transform infrared spectroscopy and zeta potential. The rounded and shaped as like spherical nanoparticles were found for G-Fe/Cu‑NPs with the size ranged 32-59 nm and the surface area was 4.452 m2/g. Then the resultant nanoparticles were utilized as a Fenton-like oxidation catalyst. The degradation …
Assessment Of Groundwater Drinking Sources In Eku And Its Environs, In The Niger-Delta Region Of Nigeria, Ki Iloba, No Akawo, Km Adamu, Or Ohwojeheri, Ma Edafiogho
Assessment Of Groundwater Drinking Sources In Eku And Its Environs, In The Niger-Delta Region Of Nigeria, Ki Iloba, No Akawo, Km Adamu, Or Ohwojeheri, Ma Edafiogho
Baghdad Science Journal
This study assessed the quality of hand-dug drinking water sources in Eku and its environs at Eku I, Samagidi, Eku 2, and Okuechi, using the weighted arithmetic water quality index method. Water samples collected from hand-dug wells at these locations returned values for analyzed parameters. Temperature 26 – 30(⁰C), dissolved Oxygen (D.O) 5.2-8mg/l, biological oxygen demand (BOD) 5.2-8(mg/l), Electrical Conductivity (EC) 77-119(µS/cm), Total suspended solids were (TSS) 20000-120000(mg/l), pH 5.31-7.09, Phosphates 2-9.2(mg/l), Alkalinity 28-160(mg/l), Turbidity, 0.02 -0.19(NTU) Total coliform 2 -48 (cfu/ml) and fungal count 1-502. Variations in the values of these parameters were only significant for phosphate, alkalinity, and …
Dc-Sign Receptor Level In Rheumatoid Arthritis Patients In Baghdad; Serological Study, Hayam A. Mohammed, Zahra’A A. Ahmed, Aymen A. Othman Alrawi
Dc-Sign Receptor Level In Rheumatoid Arthritis Patients In Baghdad; Serological Study, Hayam A. Mohammed, Zahra’A A. Ahmed, Aymen A. Othman Alrawi
Baghdad Science Journal
Rheumatoid arthritis (RA), is an autoimmune, and inflammatory disease that is closely related to the destruction of cartilage and bone. DC-SIGN are important types of C-type lectin receptors (CLRs), expressed on dendritic cells and macrophages, and have a central role in regulating innate and adaptive immunity, function as pattern recognition receptors, and as cell adhesion molecules. Recent evidence has demonstrated that DC-SIGN is involved in the pathophysiological of chronic inflammation, so DC-SIGN has been linked to several autoimmune and may play an essential indicator in the pathogenesis and progression of RA. Therefore, the purpose of this study is to determine …
Association Of Potent Inflammatory Cytokine And Oxidative Dna Damage Biomarkers In Stomach Cancer Patients, Akam Jasim Mustafa, Parween Abdulsamad Ismail
Association Of Potent Inflammatory Cytokine And Oxidative Dna Damage Biomarkers In Stomach Cancer Patients, Akam Jasim Mustafa, Parween Abdulsamad Ismail
Baghdad Science Journal
The infection with H. Pylori stimulates a signaling cascade that causes the generation of Cytokines and provokes Oxidative stress that is involved in the chronic inflammatory response leads to Gastric cancers. Reactive oxygen species (ROS) produce 8-Hydroxydeoxyguanosine (8-OHdG), the persistent oxidative DNA damage product. The study objective was to assess if there was a link between inflammatory cytokine levels and the presence of Oxidative DNA damage in Gastric tumor patients. In addition, evaluation of the diagnostic and prognostic value of Oxidative DNA damage and inflammatory cytokine biomarkers for Stomach cancers is being conducted. The study was accomplished on medically diagnosed …
Collaboration In Public And Private Partnerships, Abby M. Foreman
Collaboration In Public And Private Partnerships, Abby M. Foreman
Faculty Work Comprehensive List
For the past few decades, there has been a shift in the public sector, which has been documented by academics and thoroughly felt by public administrators. The increase of public-private partnerships as a result of contracting, privatization, and other mechanisms has changed expectations and created new demands for managers.
Library Newsletter : Issue 4 - 2022, Office Of The University Librarian
Library Newsletter : Issue 4 - 2022, Office Of The University Librarian
Office of the University Librarian Reports
- Message by Peter Gatiti Associate Vice Provost & University Librarian
- Oral History Project (University Archives)
- Book Reviews
- FAS Library
- AKU Author’s Day
- Other Highlights
- CopyrightX
- Digital Repository
- Congratulations
- Library Publications
Corrupt Or Charitable? Patient Assistance Programs And The Case For Narrowing The Breadth Of The Federal Anti-Kickback Statute, Isaac Strauss
Corrupt Or Charitable? Patient Assistance Programs And The Case For Narrowing The Breadth Of The Federal Anti-Kickback Statute, Isaac Strauss
Cardozo Law Review
No abstract provided.
Taming Immigration Trauma, Raquel E. Aldana
Taming Immigration Trauma, Raquel E. Aldana
Cardozo Law Review
This Article documents the United States’ century-long efforts to humanize our borders. In the end, law has been insufficient to tame immigration law’s enforcement. How the United States enforces borders, however, can and should be more humane. Two important principles should guide this process. First, the United States should recognize that borders’ impacts are as severe as other forms of punishment, especially when the means to enforce the immigration power have become indistinguishable from criminal enforcement. Second, human trauma should guide immigration policy toward meaningful inclusion. After significant reckoning over the travesty of shutting our borders, the United States has …
Why A New Deal Must Address The Readability Of U.S. Consumer Contracts, Michael L. Rustad
Why A New Deal Must Address The Readability Of U.S. Consumer Contracts, Michael L. Rustad
Cardozo Law Review
United States companies are increasingly drafting consumer contracts that are complex and unreadable, thus making it difficult for many Americans to comprehend terms of use that apply to goods and services. Many U.S. companies are creating terms of use that are, in effect, rights-foreclosure schemes. Many consumer agreements cap damages at a nominal amount, disclaim all warranties, limit remedies, and impose mandatory arbitration clauses and class action waivers. U.S. courts enforce these unfair mass-market contracts with few exceptions. My proposal for a New Deal for Consumer Contracts, as described in this Article, would impose a more exacting readability standard, enforcing …
The Influence Of Electrical Stimulation Pulse Frequency Of Macro-Sieve Electrode On Rat Sciatic Nerve Detection Threshold, Jingyuan Zhang
The Influence Of Electrical Stimulation Pulse Frequency Of Macro-Sieve Electrode On Rat Sciatic Nerve Detection Threshold, Jingyuan Zhang
McKelvey School of Engineering Graduate Student Theses & Dissertations
No abstract provided.
Computational Fluid Dynamics Modeling Of Hemodialysis In Patients With An Arteriovenous Fistula, Maximilian Roth
Computational Fluid Dynamics Modeling Of Hemodialysis In Patients With An Arteriovenous Fistula, Maximilian Roth
McKelvey School of Engineering Graduate Student Theses & Dissertations
With the advent of arteriovenous fistula (AVF) for use in hemodialysis, the anastomosis built for such use has become a central point of the study to understand the flow and wall shear stresses in such a system since very large wall shear stresses can lead to arterial/vein rupture. Considering the commonly used creation site of an anastomosis as connecting the radial artery to the cephalic vein, a model is created to calculate the wall shear stresses across various components of the system. The model depicts a connection of the specified vein and artery bridged together allowing the increase in blood …
Subchondroplasty - A Viable Treatment Option For Transient Bone Marrow Edema Syndrome Of The Navicular In An Adolescent: A Case Report, Tanner Marriott, Omar Fakhoury, Naem A. Mufarreh, Maxwell Pedre, Zachary Cox, Svetlana Zats
Subchondroplasty - A Viable Treatment Option For Transient Bone Marrow Edema Syndrome Of The Navicular In An Adolescent: A Case Report, Tanner Marriott, Omar Fakhoury, Naem A. Mufarreh, Maxwell Pedre, Zachary Cox, Svetlana Zats
Student Publications
Introduction: Transient bone marrow edema (TBME) is a condition that typically presents in middle-aged adults with a male to female ratio of 3:1. Cases have also been noted in females during the third trimester of pregnancy. Vitamin D deficiency has been linked to this condition as the pathophysiology demonstrates poorly mineralized osteoid in presenting lesions. It is rare for a healthy child or adolescent to present with TBME introducing the purpose of this case study. This case report aims to provide medical and surgical education on TBME in a young and healthy adolescent. To our best knowledge, this is the …
Isometric Knee Strength Is Greater In Individuals Who Score Higher On Psychological Readiness To Return To Sport After Primary Anterior Cruciate Ligament Reconstruction., Barrie S Sugarman, Zach B Sullivan, Daniel Le, Carolyn Killelea, Mallory S Faherty, Lee H Diehl, Jocelyn R Wittstein, Jonathan C Riboh, Alison P Toth, Annunziato Amendola, Dean C Taylor, Timothy C Sell
Isometric Knee Strength Is Greater In Individuals Who Score Higher On Psychological Readiness To Return To Sport After Primary Anterior Cruciate Ligament Reconstruction., Barrie S Sugarman, Zach B Sullivan, Daniel Le, Carolyn Killelea, Mallory S Faherty, Lee H Diehl, Jocelyn R Wittstein, Jonathan C Riboh, Alison P Toth, Annunziato Amendola, Dean C Taylor, Timothy C Sell
Ambulatory and Primary Care Articles
BACKGROUND: Anterior cruciate ligament (ACL) injury is extremely common among athletes. Rate of second ACL injury due to surgical graft rupture or contralateral limb ACL injury is approximately 15-32%. Psychological readiness to return to sport (RTS) may be an important predictor of successful RTS outcomes. Psychological readiness can be quantified using the ACL Return to Sport after Injury (ACL-RSI) questionnaire, with higher scores demonstrating greater psychological readiness.
PURPOSE: The purpose of this study was to investigate differences in functional performance and psychological readiness to return to sport among athletes who have undergone primary ACL reconstruction (ACLR).
STUDY DESIGN: Descriptive cohort …
Dysregulation Of Complement System In Neuropsychiatric Disorders: A Mini Review, Danny Perez Sierra, Ashutosh Tripathi, Anilkumar Pillai
Dysregulation Of Complement System In Neuropsychiatric Disorders: A Mini Review, Danny Perez Sierra, Ashutosh Tripathi, Anilkumar Pillai
Faculty, Staff and Student Publications
Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and …