Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (23776)
- Social and Behavioral Sciences (13360)
- Education (8684)
- Life Sciences (7426)
- Medical Specialties (6950)
-
- Law (6281)
- Arts and Humanities (5109)
- Public Health (4422)
- Physical Sciences and Mathematics (4288)
- Medical Sciences (3929)
- Psychology (3179)
- Business (2869)
- Higher Education (2786)
- Engineering (2632)
- Nursing (2477)
- Sociology (2215)
- Diseases (1985)
- Public Affairs, Public Policy and Public Administration (1745)
- Oncology (1535)
- Medical Education (1475)
- Environmental Sciences (1433)
- Sports Sciences (1337)
- Communication (1248)
- Mental and Social Health (1245)
- Health and Physical Education (1224)
- History (1202)
- Rehabilitation and Therapy (1178)
- Bioinformatics (1165)
- Biomedical Informatics (1114)
- Biology (998)
- Institution
-
- The Texas Medical Center Library (3382)
- Washington University School of Medicine (1713)
- Walden University (1362)
- University of Nebraska - Lincoln (1330)
- Chulalongkorn University (1187)
-
- University of Colorado Law School (986)
- Thomas Jefferson University (932)
- Western Michigan University (912)
- University of Montana (903)
- University of Florida Levin College of Law (839)
- University of Mississippi (825)
- Liberty University (800)
- Utah State University (794)
- University of New Hampshire (791)
- University of South Carolina (783)
- University of Plymouth (776)
- University of Kentucky (771)
- University of Alabama at Birmingham (763)
- Georgia Southern University (753)
- City University of New York (CUNY) (751)
- University of Central Florida (713)
- Universitas Indonesia (712)
- Edith Cowan University (711)
- San Jose State University (694)
- University of Memphis (692)
- Aga Khan University (649)
- University of Arkansas, Fayetteville (631)
- Western Kentucky University (629)
- Louisiana State University (620)
- Nova Southeastern University (620)
- Keyword
-
- Humans (3416)
- COVID-19 (2836)
- Animals (944)
- Female (890)
- Mice (668)
-
- Education (641)
- Mental health (629)
- Male (607)
- ICTS (Institute of Clinical and Translational Sciences) (530)
- Michigan (506)
- Adult (485)
- Pandemic (483)
- Child (433)
- Depression (417)
- United States (400)
- SARS-CoV-2 (399)
- Anxiety (327)
- Retrospective Studies (325)
- Children (320)
- Health (320)
- Obesity (319)
- Gender (306)
- Leadership (301)
- Physical activity (298)
- Release (298)
- Stress (294)
- Higher education (292)
- Covid-19 (290)
- Adolescent (289)
- Students (286)
- Publication
-
- Faculty, Staff and Student Publications (2045)
- Theses and Dissertations (1575)
- 2020-Current year OA Pubs (1435)
- Walden Dissertations and Doctoral Studies (1275)
- Session Laws 2001-Present (914)
-
- Faculty Publications (876)
- Dissertations (858)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (836)
- Faculty, Staff and Students Publications (784)
- Electronic Theses and Dissertations (726)
- University of Montana Course Syllabi, 2021-2025 (590)
- Research outputs 2022 to 2026 (579)
- Baltic Journal of Health and Physical Activity (573)
- Florida Law Review (567)
- Doctoral Dissertations and Projects (526)
- Faculty Scholarship (481)
- Honors Theses (461)
- International Journal of Exercise Science: Conference Proceedings (417)
- Articles (390)
- Browse All News (380)
- Silver Bow Creek/Butte Area Superfund Site (333)
- Library Philosophy and Practice (e-journal) (330)
- Theses (306)
- Florida Historical Quarterly (300)
- USF Tampa Graduate Theses and Dissertations (278)
- Open Access Publications (270)
- Turkish Journal of Medical Sciences (244)
- Patient Education Projects (243)
- Publications and Research (243)
- Master's Theses (232)
- Publication Type
Articles 5131 - 5160 of 76548
Full-Text Articles in Entire DC Network
“What’S Belonging Got To Do With It?”: An Exploration Of Campus Racial Climate And Sense Of Belonging In Black Counseling Students Attending Predominately White Institutions In The North Atlantic Region, Erin Durrah
Graduate Theses and Dissertations
Diversity, equity, and inclusion (DEI) dialogues are raging across campuses throughout the U.S. with specific focus on the needs of Black student populations in the aftermath of the George Floyd, Breonna Taylor and Ahmaud Arbury murders. However, if the supportive spirit of the DEI initiatives is undermined by a hostile campus climate and local community, it may negatively impact the learning environment isolating the target population, while also effecting their potential for successful completion of their programs. The current qualitative study aims to explore the perceptions of belonging expressed by Black graduate students enrolled in Council for Accreditation of Counseling …
Optimization Of Clostridium Septicum Antigen Production And Evaluation Of Vaccine Administration Parameters For A Candidate Bacterin-Toxoid To Prevent Dermatitis In Commercial Turkeys, Aaron Forga
Graduate Theses and Dissertations
The objective of this thesis was to optimize the hemolytic activity of two isolates of Clostridium septicum to evaluate if hemolytic titer of C. septicum antigen at time of formalin inactivation corresponded to increased serum antibody titer to the C. septicum alpha-toxin of turkeys immunized with an experimental formalin inactivated bacterin-toxoid vaccine. Chapter 1 provides a brief overview of the thesis. Chapter 2 consists of a literature review focused on clostridial dermatitis, specifically C. septicum-associated dermatitis (cellulitis) that affects commercial turkeys. Chapter 3 outlines our attempts to optimize an experimental autogenous bacterin-toxoid vaccine as a potential strategy to mitigate clostridial …
Differential Impacts Of Hhv-6a Versus Hhv-6b Infection In Differentiated Human Neural Stem Cells, Elham Bahramian
Differential Impacts Of Hhv-6a Versus Hhv-6b Infection In Differentiated Human Neural Stem Cells, Elham Bahramian
Graduate Theses and Dissertations
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there areonly three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7. Initially, HHV-6A and HHV-6B were considered as two variants of the same virus (i.e., HHV6). Despite high overall genetic sequence identity (~90%), HHV-6A and HHV-6B are now recognized as two distinct viruses. Sequence divergence (e.g., >30%) in key coding regions and significant differences in physiological and biochemical profiles (e.g., use of different receptors for viral entry) underscores the conclusion that HHV-6A and HHV-6B are distinct viruses of the β-herpesvirinae. Despite these viruses being implicated as causative agents in …
Understanding Perceptions Of Graduating Seniors From Rural Schools On Higher Education: A Preregistered Study, Desiree Denise Brake
Understanding Perceptions Of Graduating Seniors From Rural Schools On Higher Education: A Preregistered Study, Desiree Denise Brake
Graduate Theses and Dissertations
The purpose of this qualitative case (preregistered) study is to interview rural young Americans, deeply explore how they think about higher education as they prepare for life beyond high school, and analyze how those views and perceptions translate into barriers or motivators to its pursuit. Rural Americans feel less optimistic about their financial futures, find it more difficult to find a job in their communities, and believe their children will have a lower standard of living than their parents when they reach their parents’ age (Morin, 2016). Rural students are more likely to graduate from high school than their urban …
Female Adults’ Experiences Of Sexual Harassment And Assault In The Presence Of Others: A Qualitative Analysis Of The Effectiveness And Consequences Of Bystander Intervention Strategies, Kayla Ford
Graduate Theses and Dissertations
Bystander intervention programs aim to reduce the acceptance of violence against women by fostering prosocial behavior from community members, and often provide knowledge on behaviors associated with sexual risk and ways a bystander can intervene. However, there is limited knowledge on which intervention strategies are used, and how these interventions impact perpetrator behavior and incidence of verbal and physical harm to those involved. There is even less research on these phenomena from the perspective of the victim. To address these gaps, the current study utilized a qualitative approach to (1) identify bystander intervention strategies employed; (2) discuss trends of the …
Exploring Leadership In An Extreme Environment: A Haiti Farm Project, Tami Strickland
Exploring Leadership In An Extreme Environment: A Haiti Farm Project, Tami Strickland
Graduate Theses and Dissertations
This qualitative case study examined the impact Situational Leadership Theory II® has on followers in a small community in Haiti. Many studies have examined Situational Leadership Theory II® in corporate environments, but not in the low-income context of Haiti. The study focused on how the leadership characteristics and adaptability levels of an expatriate influenced the construction and the ongoing management of a Haiti egg farm project, which is timely based on the volatility currently in the country prior to and after the assassination of President Jovenel Moïse in 2021. Using various data gathering instruments, the study explored the expatriate’s leadership …
Investigating How Facilitators View The Functions And Perceived Values Of Reflective Activities On Transformative Learning Amongst People In Addiction, James Ryan Eller
Investigating How Facilitators View The Functions And Perceived Values Of Reflective Activities On Transformative Learning Amongst People In Addiction, James Ryan Eller
Graduate Theses and Dissertations
Although there has been considerable empirical support for the effect of reflection, and specifically reflective activities, within the domain of transformative learning (Ballon & Skinner, 2008; King, 2004; Mezirow, 2012; Roessger, 2014; Taylor, 2017), there is a gap in the literature concerning the value of formal reflective activities when used with people in addiction recovery programs. I will interview facilitators of addiction programs to inquire on the methods of reflection their programming provides people in addiction, investigate the effectiveness of the activities, and then determine the connections (if any) between formal reflective activities and transformation in people in addiction. This …
Reliability Enhancing Control Algorithms For Two-Stage Grid-Tied Inverters, Yuheng Wu
Reliability Enhancing Control Algorithms For Two-Stage Grid-Tied Inverters, Yuheng Wu
Graduate Theses and Dissertations
In the photovoltaic (PV) generation system, two types of grid-tied inverter systems are usually deployed: the single-stage grid-tied inverter system and the two-stage grid-tied inverter system. In the single-stage grid-tied inverter system, the input of the inverter is directly connected to the PV arrays, while an additional dc-dc stage is inserted between the PV arrays and the dc-ac inverter in the two-stage design. The additional dc-dc stage could provide a stable dc-link voltage to the inverter, which also enables new design possibilities, including the multi-MPPT operation and solar-plus-storage application. Thus, the two-stage grid-tied inverter has been widely used in the …
Advisor-Student Communication In Preparation For Online Education, Jennifer Clare Hoelzeman
Advisor-Student Communication In Preparation For Online Education, Jennifer Clare Hoelzeman
Graduate Theses and Dissertations
The University of Arkansas System eVersity was established in 2014 by the University of Arkansas System Board of Trustees. More than 80% of the student population at the institution is non-traditional, with time or location restrictions that prevent participation in on-campus degree programs. eVersity Engage is a required orientation course completed by all students before enrolling at eVersity. Engage is intended to introduce students to institutional policies and resources, set student expectations for online learning at the institution, and provide the foundation for academic success as an online student. After completing Engage, students schedule an appointment with their Academic Success …
Micronutrient Concentration Effects On Lettuce Growth And Susceptibility To Pythium, Kalyn M. Helms
Micronutrient Concentration Effects On Lettuce Growth And Susceptibility To Pythium, Kalyn M. Helms
Graduate Theses and Dissertations
In hydroponic production waterborne pathogens such as Pythium are ubiquitous and continually threaten a wide range of Controlled Environment Agriculture (CEA) crops in hydroponic production, including but not limited to: lettuce, spinach, basil, arugula, cucumber, tomato, sweet pepper, roses, chrysanthemums, and cannabis (Sutton et al., 2006; Gull, 2002; McGehee and Raudales, 2021; Gillespie, 2020). Despite extensive sanitation measures, disease control in hydroponics is fallible and requires constant surveillance and management to minimize outbreaks (Sutton et al., 2006). A potential disease suppression strategy is to increase micronutrient concentrations within hydroponic systems to naturally strengthen plant defenses against pathogens such as Pythium. …
The Impact Of Video-Taped Social Modeling On Alcohol Outcome Expectancies Of Young Adults And The Role Of Social Anxiety, Kyle Kevin Jackson
The Impact Of Video-Taped Social Modeling On Alcohol Outcome Expectancies Of Young Adults And The Role Of Social Anxiety, Kyle Kevin Jackson
Graduate Theses and Dissertations
Alcohol outcome expectancies (AOEs) represent people’s ideas about the effects of alcohol (Fromme, 1993). Positive AOEs particularly have been identified as a potential risk factor for hazardous drinking (e.g., Brown et al., 1985). The exact mechanisms that modify AOEs are not fully understood. Further, people higher in social anxiety may be especially receptive to social modeling due to attentional bias shift towards others in social contexts (Rapee & Heimberg, 1997). The current study examined how social anxiety and social modeling associate with AOEs. It was hypothesized that 1) those in the social modeling treatment condition would have higher social anxiety-adjacent …
Using Copper Oxide And Zwitterions To Prevent Membrane Fouling And Optimizing Ultrafiltration Membrane Fabrication With Green Solvents, Cannon Hackett
Using Copper Oxide And Zwitterions To Prevent Membrane Fouling And Optimizing Ultrafiltration Membrane Fabrication With Green Solvents, Cannon Hackett
Graduate Theses and Dissertations
Membrane fouling and sustainable production of membranes are two of the most important challenges in membrane science. Chapter 1 of this dissertation introduces these challenges and covers previous research that has been done in those areas. Additionally, the objectives of this dissertation are stated. In chapter 2, a study was done in which polyethersulfone ultrafiltration membranes were functionalized with copper oxide nanoparticles and zwitterions for the purpose of reducing fouling on the membrane surface. Characterization confirmed the attachment of each component to the membranes. Dead-end filtration was performed with water and bovine serum albumin solution and showed that the functionalization …
Multivariate Fairness For Paper Selection, Reem Alsaffar
Multivariate Fairness For Paper Selection, Reem Alsaffar
Graduate Theses and Dissertations
Peer review is the process by which publishers select the best publications for inclusion in a journal or a conference. Bias in the peer review process can impact which papers are selected for inclusion in conferences and journals. Although often implicit, race, gender and other demographics can prevent members of underrepresented groups from presenting at major conferences. To try to avoid bias, many conferences use a double-blind review process to increase fairness during reviewing. However, recent studies argue that the bias has not been removed completely. Our research focuses on developing fair algorithms that correct for these biases and select …
Gastrostomy Tube Dislodged, Children's Mercy Kansas City
Gastrostomy Tube Dislodged, Children's Mercy Kansas City
Clinical Pathways (Formally Known As Care Process Models)
No abstract provided.
Gunita Bilang Pandaigdigang Kamalayan Ng Nagpapatuloy Na Kasaysayan Sa Global Na Lipunan: Pagturing Sa Eksibisyong Gintong Liwayway: Sining Ng Progresibong Pagbabago, Gian Carlo Delgado
Gunita Bilang Pandaigdigang Kamalayan Ng Nagpapatuloy Na Kasaysayan Sa Global Na Lipunan: Pagturing Sa Eksibisyong Gintong Liwayway: Sining Ng Progresibong Pagbabago, Gian Carlo Delgado
Katipunan
Layon ng papel na ito na suriin ang mga sining na naglalahad ng mga konsepto ng gunita sa eksibisyong Gintong Liwayway: Sining ng Progresibong Pagbabago ng UP Artists’ Circle Fraternity, na ginanap sa Anima Art Space. Ang mga konseptong ito ng gunita ay itinuturing na kaakibat ng pagsasapantaha ng pagbabago na ipinaparating sa paglikha ng isang imagined world. Ang imagined world ay kinikilala bilang isang pandaigdigang kamalayan na nakaugnay sa Social Realism, na isang masining na paraan ng pagpapahayag ng paghihimagsik. Tinuturol ng pagturing na ito sa eksibisyon ang konsepto ng gunita bilang aspekto ng buhay at impluwensiya ng mga …
An Empirical Study On The Types Of Consumers And Their Preferences For E-Waste Recycling With A Points System, Hua Zhong, Shan Zhou, Zhiyao Zhao, Hao Zhang, Jing Nie, Palizhati Simayi
An Empirical Study On The Types Of Consumers And Their Preferences For E-Waste Recycling With A Points System, Hua Zhong, Shan Zhou, Zhiyao Zhao, Hao Zhang, Jing Nie, Palizhati Simayi
Michigan Tech Publications, Part 1
Improper disposal of electronical waste (e-waste) causes harm to both public health and the environment, and how to effectively recycle and reduce electronical waste has become a common concern around the world. This study focuses on the design of the points system to encourage consumer participation in e-waste recycling programs. Based on the Theory of Planned Behavior (TPB) model, a semi-experimental design method was applied to influence consumer cognition and behavioral intention through information provision in survey design. Two surveys were conducted in two years apart to understand the temporal trend of consumer types and their preferences for the design …
Exploring The Interpersonal, Leadership, And Organizational Factors Related To The Burnout Of Bilingual, Latinx Professional School Counselors [Explorando Los Factores Interpersonales, De Liderazgo Y Organizacionales Relacionados Con El Agotamiento De Los Consejeros Escolares Profesionales Bilingües Y Latine], Crystal Marie Prado
Theses and Dissertations
This study explored the relationship between interpersonal competencies, educational leadership styles of campus principals, organizational practices, and the burnout of professional school counselors (PSCs). A mixed-methods research design was utilized to examine the correlation between identified predictor variables and the level of burnout as measured by the five dimensions of the Counselor Burnout Inventory (CBI; Lee et al., 2007), the three subscales of the Maslach Burnout Inventory: Educators Survey (MBI-ES, Maslach et al., 1986), and personal narratives documenting the participating PSC's most significant professional experiences. The investigation included 100 bilingual, Latinx PSCs from four urban/suburban school districts of border towns …
Regulation Of Health-Related Artificial Intelligence In Medical Devices: The Canadian Story, Michael Da Silva, Colleen M. Flood, Matthew Herder
Regulation Of Health-Related Artificial Intelligence In Medical Devices: The Canadian Story, Michael Da Silva, Colleen M. Flood, Matthew Herder
UBC Law Review
No abstract provided.
Directors' Liability In Canadian Tax Law: Critically Analyzing The Due Diligence Standard, Samuel Singer, Monica Cheng
Directors' Liability In Canadian Tax Law: Critically Analyzing The Due Diligence Standard, Samuel Singer, Monica Cheng
UBC Law Review
No abstract provided.
"The Next 10 Years": Keynote Address On The 10th Anniversary Of The Federation Of Asian Canadian Lawyers, Carol Liao
"The Next 10 Years": Keynote Address On The 10th Anniversary Of The Federation Of Asian Canadian Lawyers, Carol Liao
UBC Law Review
No abstract provided.
Refugee-Background Students In New Zealand And The United States: Roots And Results Of Educational Policies And Practices, Jody L. Mcbrien, Maria Hayward
Refugee-Background Students In New Zealand And The United States: Roots And Results Of Educational Policies And Practices, Jody L. Mcbrien, Maria Hayward
Journal of Global Education and Research
Both the United States (US) and New Zealand (NZ) have been resettling refugees since the Second World War. As such, and because of several international treaties signed by both countries, they must concern themselves with the education of resettled refugee students in their nations. In this study, the researchers examine the international agreements and national resettlement policies that shape these nations’ refugee education policies. Second, educational practices for refugee students in the US and NZ using phenomenological qualitative research based on observations, interviews, and focus groups with teachers and refugee students are examined. The researchers conclude that the more systematic …
Distress In The Workplace: Characterizing The Relationship Of Burnout Measures To The Occupational Depression Inventory, Irvin Sam Schonfeld, Renzo Bianchi
Distress In The Workplace: Characterizing The Relationship Of Burnout Measures To The Occupational Depression Inventory, Irvin Sam Schonfeld, Renzo Bianchi
Publications and Research
Burnout has been found to problematically overlap with depression. However, the generalizability of this finding remains disputed. This study examined burnout–depression overlap using the recently developed Occupational Depression Inventory (ODI) and two burnout measures, the Maslach Burnout Inventory (MBI) and the Copenhagen Burnout Inventory (CBI). The study involved two teacher samples employed in France (N = 1,450) and New Zealand (N = 492). We found the correlations of the ODI with (a) the MBI’s emotional exhaustion (EE) subscale and (b) the CBI to reach .80. An explanation of these high correlations based on content overlap in fatigue-related items was ruled …
The Development Of Labor Law In Outer Space: A Comparison With The American Frontier And The High Seas, Connor Hogan
The Development Of Labor Law In Outer Space: A Comparison With The American Frontier And The High Seas, Connor Hogan
Journal of Space Law
No abstract provided.
Impacts Of Feeding Biochar To Beef Cattle On Greenhouse Gas Emissions And Performance And Characterizing Yearling Steers Grazing Smooth Bromegrass Pasture Using Gps, Holly A. Heil
Department of Animal Science: Dissertations, Theses, and Student Research
As global warming continues to rise, the pressure and growing demand for sustainable animal production is increasing. Livestock naturally produce greenhouse gas emissions through enteric fermentation. Dietary manipulation strategies have been sought out to decrease emissions in ruminants using feed additives.
Two independent finishing feedlot experiments evaluated two types of biochar and its effects on animal performance, carcass characteristics and greenhouse gas emissions. Experiment 1 utilized pistachio shell biochar and experiment 2 utilized biochar sourced from ponderosa pine wood waste, both types included at 1% of the diet DM. The addition of biochar to the diet did not impact animal …
The Nebraska 4-H Equine Advancement Level Program’S Role In Positive Youth Development Using The Five Cs Model: An Exploratory Study, Eunhye Mccarthy
The Nebraska 4-H Equine Advancement Level Program’S Role In Positive Youth Development Using The Five Cs Model: An Exploratory Study, Eunhye Mccarthy
Department of Animal Science: Dissertations, Theses, and Student Research
Positive youth development (PYD) focuses on developing the strengths of youth through positive activities and behaviors rather than reducing negative tendencies. A well-researched model of PYD is the five C’s model that is popularly used in youth development organizations such as 4-H. The Nebraska 4-H Equine Advancement Level program was intended to serve as a guidebook for instruction and assessment of youth as they learn more about horses and horsemanship skills. Each of the four levels has an emphasis in developing a 4-H member’s responsibility, self-discipline, self-reliance, patience, and pride of accomplishments. The program was started approximately 30 years ago …
Variance Component Estimates For Growth Traits In Beef Cattle Using Selected Variants From Imputed Low-Pass Sequence Data, Chad A. Russell
Variance Component Estimates For Growth Traits In Beef Cattle Using Selected Variants From Imputed Low-Pass Sequence Data, Chad A. Russell
Department of Animal Science: Dissertations, Theses, and Student Research
A beef cattle population (n = 2,343) was used to assess the impact of variants identified from imputed low-pass sequence (LPS) on the estimation of variance components and genetic parameters of birth weight (BWT) and post weaning gain (PWG). Variants were selected based on functional impact and were partitioned into four groups (Low, Modifier, Moderate, High) based on predicted functional consequences and re-partitioned based on consequence of mutation, such as missense and untranslated region variants, into six groups (G1-G6). Each subset was used to construct a genomic relationship matrix (GRM) for univariate animal models. Multiple analyses were conducted to …
Environmental Determination Of Gastrointestinal Parasitism In Katahdin Sheep, Brian Arisman
Environmental Determination Of Gastrointestinal Parasitism In Katahdin Sheep, Brian Arisman
Department of Animal Science: Dissertations, Theses, and Student Research
Gastrointestinal nematodes (GIN) negatively affect the performance and wellbeing of sheep and are difficult to control due to anthelmintic resistance. Producers are therefore choosing breeds naturally resistant to GIN infection, such as the Katahdin. Katahdin are raised in various climates and management systems in the U.S., and those environmental factors can be combined into eco-management clusters. We hypothesized that GIN challenge varies predictably based on the characteristics of these clusters. Katahdin producers from across the U.S. were surveyed for management information. Body weights (BW), fecal egg counts (FEC) and FAMACHA scores (FAM) were collected on 3,527 Katahdin lambs around 90 …
Polygenic Transcriptome Risk Scores (Ptrs) Can Improve Portability Of Polygenic Risk Scores Across Ancestries, Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer, Nancy J. Cox, Heather E. Wheeler, Hae Kyung Im
Polygenic Transcriptome Risk Scores (Ptrs) Can Improve Portability Of Polygenic Risk Scores Across Ancestries, Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer, Nancy J. Cox, Heather E. Wheeler, Hae Kyung Im
Biology: Faculty Publications and Other Works
Background: Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry. Results: We introduce the polygenic transcriptome risk score (PTRS), which is based on predicted transcript levels (rather than SNPs), and explore the portability of PTRS across populations using UK Biobank data. Conclusions: We show that PTRS has a significantly higher portability (Wilcoxon p=0.013) in the African-descent samples where the loss of performance is most acute with better performance than PRS when …
Internal And External Validation Of An Alcohol Biomarker For Screening In Trauma, Majid Afshar, Kenneth Baker, Josefine Corral, Erin Ross, Erin Lowery, Richard Gonzalez, Ellen L. Burnham, Rachael A. Callcut, Lucy Z. Kornblith, Carolyn Hendrickson, Elizabeth J. Kovacs, Cara Joyce
Internal And External Validation Of An Alcohol Biomarker For Screening In Trauma, Majid Afshar, Kenneth Baker, Josefine Corral, Erin Ross, Erin Lowery, Richard Gonzalez, Ellen L. Burnham, Rachael A. Callcut, Lucy Z. Kornblith, Carolyn Hendrickson, Elizabeth J. Kovacs, Cara Joyce
Biostatistics Collaborative Core: Faculty Publications and Other Works
Objective: We aimed to examine biomarkers for screening unhealthy alcohol use in the trauma setting.
Summary and Background Data: Self-report tools are the practice standard for screening unhealthy alcohol use; however, their collection suffers from recall bias and incomplete collection by staff.
Methods: We performed a multi-center prospective clinical study of 251 adult patients who arrived within 24 hours of injury with external validation in another 60 patients. The Alcohol Use Disorders Identification Test served as the reference standard. The following biomarkers were measured: (1) PEth; (2) ethyl glucuronide; (3) ethyl sulfate; (4) gammaglutamyl-transpeptidase; (5) carbohydrate deficient transferrin; and (6) …