Digital Commons Network^™

Spatiotemporal Change Detection Of The Alpine Meadows At Holcomb Valley, San Bernardino Mountain National Forest, Using Gis And Remote Sensing Techniques, Rama Ewing

Electronic Theses, Projects, and Dissertations

Holcomb Valley, with a general elevation between 2200-2257m, is in the Northeast of Big Bear Lake in the San Bernardino Mountains. Holcomb Valley is covered by Alpine meadows, unlike most mountain landscapes, which are rarely found in Mediterranean climates such as California. The cultural-environmental history of the San Bernardino Mountains in the past century speaks of intense anthropogenic activities such as timbering, grazing, gold mining, and extreme climate changes (i.e., drought, fires, floods). A study is conducted to identify and calculate the changes in the Alpine meadows at Holcomb Valley. The climatical data has been acquired to compute and visualize …

Coping Strategies And Self-Compassion As Protective Factors In The Infant And Early Childhood Mental Health Workforce, Megan Wolff

Electronic Theses and Dissertations

The mental health field experiences high levels of stress, resulting in a greater risk of poor professional quality of life, likely exacerbated by the additional stress associated with COVID-19. The present study examined the effect COVID-19 stress had on the professional quality of life of the infant and early childhood mental health (IECMH) workforce and whether coping strategies and self-compassion acted as protective factors. Results indicated that higher COVID-19 stress was associated with higher burnout and secondary traumatic stress (STS) and lower compassion satisfaction (CS). The results also showed that the pathway from COVID-19 stress to burnout was moderated by …

The Lived Experiences Of Students Who Are Single Parents And Attending Community College: A Phenomenological Study, Debbie Johnson

Electronic Theses and Dissertations

This qualitative study used phenomenological research methods to explore the lived experiences of single parents attending community college. The phenomenological research design was used to better understand participant experiences by examining the participant’s view of their situation. Thirteen single-parent students in community colleges in the United States were selected using purposeful sampling techniques. The participants included ten female participants and three male participants. Of these participants, nine students attended full-time, and four attended part-time. Each student participated in one-on-one interviews using Zoom technology.

The participants provided their perceptions of their experiences as single parents attending community college. These participants described …

Potential Use Of Engineered Nanoparticles In Ocean Fertilization For Large-Scale Atmospheric Carbon Dioxide Removal, Peyman Babakhani, Tanapon Phenrat, Mohammed Baalousha M.Sc, Ph.D., Kullapa Soratana, Caroline L. Peacock, Benjamin S. Twining, Michael F. Hochella Jr.

Faculty Publications

Artificial ocean fertilization (AOF) aims to safely stimulate phytoplankton growth in the ocean and enhance carbon sequestration. AOF carbon sequestration efficiency appears lower than natural ocean fertilization processes due mainly to the low bioavailability of added nutrients, along with low export rates of AOF-produced biomass to the deep ocean. Here we explore the potential application of engineered nanoparticles (ENPs) to overcome these issues. Data from 123 studies show that some ENPs may enhance phytoplankton growth at concentrations below those likely to be toxic in marine ecosystems. ENPs may also increase bloom lifetime, boost phytoplankton aggregation and carbon export, and address …

Subchronic Oral Cylindrospermopsin Exposure Alters The Host Gut Microbiome And Is Associated With Progressive Hepatic Inflammation, Stellate Cell Activation, And Mild Fibrosis In A Preclinical Study, Punnag Saha, Macayla Upright, Dipro Bose, Subhajit Roy, Ayushi Trivedi, Madhura More, Geoff Scott Ph.D., Bryan W. Brooks, Saurabh Chatterjee

Faculty Publications

Epidemiological studies have reported a strong association between liver injury and incidences of hepatocellular carcinoma in sections of humans globally. Several preclinical studies have shown a strong link between cyanotoxin exposure and the development of nonalcoholic steatohepatitis, a precursor of hepatocellular carcinoma. Among the emerging threats from cyanotoxins, new evidence shows cylindrospermopsin release in freshwater lakes. A known hepatotoxin in higher concentrations, we examined the possible role of cylindrospermopsin in causing host gut dysbiosis and its association with liver pathology in a mouse model of toxico-pharmacokinetics and hepatic pathology. The results showed that oral exposure to cylindrospermopsin caused decreased diversity …

Analyzing Emerging Adulthood Narratives And The Role Of Anxiety In Developmental Functioning, Daryl Parungao

Electronic Theses and Dissertations

Emerging adulthood is a developmental period characterized by the themes of identity exploration, instability, feeling in-between, being self-focused, and exploring possibilities (Arnett, 2006). Emerging adults are at higher risk for anxiety as they navigate novel developmental experiences and responsibilities (Kranszler et al., 2019). This study explores whether these themes map on to the experiences of modern-day emerging adults, and whether developmental functioning corresponds to anxiety. College students completed standard questionnaires and provided free-text responses about adjusting to adulthood. Identity exploration and instability were perceived as the most positive and negative aspects of aging, respectively, though response-type varied by participant demographics. …

Investigating The Pi3k/Akt/Atm Pathway, Telomeric Dna Damage, T Cell Death, And Crispr/Cas9-Mediated Gene Editing During Acute And Chronic Hiv Infection, Sushant Khanal

Electronic Theses and Dissertations

Human Immunodeficiency Virus (HIV) infection initiates major metabolic and cell- survival complications. Anti-retroviral therapy (ART) is the current approach to suppress active HIV replication to a level of undetected viral load, but it is not a curative approach. Newer and sophisticated gene editing technologies could indeed be a potent antiviral therapy to achieve a clinical sterilization/cure of HIV infection. Chronic HIV patients, even under a successful ART regimen, exhibit a low-grade inflammation, immune senescence, premature aging, telomeric DNA attrition, T cell apoptosis, and cellular homeostasis. In this dissertation, we investigated CD4 T cell homeostasis, degree of T cell apoptosis, an …

Correctional Career Pathways: A Reentry Program For Incarceration, Taylor M. Dula

Electronic Theses and Dissertations

For the past several decades, the United States led the world in incarceration rates. With nearly 2.3 million people being held in state or federal prisons or local jails in 2019, incarceration rates in the United States are over four times higher than in other developed countries. Disparities exist by gender, race, ethnicity, and other special populations. Males are 13 times more likely to be incarcerated than females. Additionally, black males are 5.7 times and Hispanic males are 2.8 times more likely to be incarcerated than white males. Individuals who experience incarceration have poorer mental and physical health outcomes. People …

An Acute Sense Of Place: The Songs Of Norman Blake, Thomas Jutz

Electronic Theses and Dissertations

American flat-picking guitarist, singer and songwriter Norman Blake holds legendary status among guitar players, bluegrass, and folk musicians.

The aim of this research is to analyze the interaction of sense of place in Norman Blake’s songwriting. This research will explore the techniques Blake uses to create that acute sense of place. Elements of literary criticism, cultural geography, ethnomusicology, and sense of place studies, as well as historical background information on Northern Alabama and North Georgia will be employed to show how this particular region of Southeastern Appalachia has informed Blake’s songwriting.

The research questions that I aim to answer are …

Community College Faculty’S Perceptions Of Culturally Responsive Teaching, Sarah Tolbert-Hurysz

Electronic Theses and Dissertations

This qualitative study sought to understand community college faculty’s perceptions of and experiences with culturally responsive teaching. Participants were full- and part-time faculty currently employed at community colleges in the Southeastern United States and purposefully selected to provide information-rich data. Data collected from the semi-structured, in-depth interviews with the participants were coded and thematically analyzed. Emerging themes included faculty’s inclusion of varied categories of cultural diversity when describing students; limited knowledge related to culturally responsive teaching; perception that culturally responsive teaching is centered on connecting and building relationships with students; belief in the value of providing students exposure to different …

A Functional Study Of Topological Dna Problem In Human T Cells During Chronic Viral Infection, Xindi Dang

Electronic Theses and Dissertations

T cells play an important role in adaptive immune system against viral infections, while premature aging and dysfunction of T cells induced by unrepaired DNA damages are always non-negligible snags during the long-term of fighting with chronic viral infections, such as Hepatitis B virus (HBV), Hepatitis C virus (HCV) or Human Immunodeficiency Virus (HIV) infection. In this dissertation, we investigated the role of topological DNA damage in reprogramming telomeric DNA damage responses (DDR), mitochondrial metabolisms, and T cell functions using CD4+ T cells derived from individuals with chronic viral infections or healthy subjects treated with topoisomerase inhibitors. The healthy human …

Opinion Mining Of Bird Preference In Wildlife Parks, Isiwat Adenopo

Electronic Theses and Dissertations

Opinion Mining is becoming the fastest growing area to extract useful and insightful information to support decision making. In the age of social media, user’s opinions and discussions have become a highly valuable source to look for users preferences, likes, and dislikes.

The industry of wildlife parks (or zoos) is a competitive domain that requires careful analysis of visitor’s opinions to understand and cater for their preferences when it comes to wildlife. In this thesis, an opinion mining approach was proposed and applied on textual posts on the social media platform, Twitter, to extract the popularity, polarity (sentiment), and emotions …

A Phenomenological Study Of Tenure-Track Faculty Serving In Dual Roles As Administrators, Keri L. Carter

Electronic Theses and Dissertations

This qualitative, phenomenological study explores the lived experiences of tenure-track faculty serving in dual roles as administrators at Carnegie classified R2 and R3 higher education institutions within the United States. Fourteen participants completed one-on-one, semi-structured interviews about their lived experiences as tenure-track faculty members serving in dual roles. Participants discussed rewards and motivations as well as challenges. Additionally, participants discussed perceptions of their academic identities. Key themes emerged during data analysis. Rewards and motivations included the following: Community change agent and student advocate, a “seat at the table,” collegiality, flexibility, confidence from prior experience and clear tenure procedures, and job …

Importance Of The Microhabitat And Microclimate Conditions In The Northern Gray-Cheeked Salamander (Plethodon Montanus) Across An Elevation Gradient, Trevor Chapman

Electronic Theses and Dissertations

The southern Appalachian Mountains have among the highest salamander diversity in the world, largely due to local speciation in the family Plethodontidae. Plethodontid salamanders (i.e., lungless salamanders) are particularly sensitive to habitat climate conditions due to their reliance on cutaneous respiration, and their immediate environmental conditions (microhabitat) likely influence their dispersion and activity more than the large-scale atmospheric conditions. The Northern Gray-cheeked salamander (Plethodon montanus) is restricted to high elevations in the Appalachian Mountains. Our goal was to investigate the relationship between P. montanus and its microhabitat by examining behavioral preference for climatic conditions, characterizing the microclimate with …

The Folk Festival Of The Smokies And The Role Of Music Festivals In Preserving Old-Time Music In Appalachia, Keegan Luckey-Smith

Electronic Theses and Dissertations

This thesis examines the history of the Folk Festival of the Smokies, which sought to preserve old-time music as an expression of southern Appalachian regional culture. The study uses qualitative methods, including personal interviews with one of the founders and significant festival participants, supplemented with archival and historical research into photographs, festival performances and literature regarding the festival. Since the festival operated for thirty-three years as a small festival in a relatively isolated location in eastern Tennessee, this case study serves as an example of the role of festivals in intangible cultural heritage preservation in relatively rural settings. The legacy …

Perceptions Of Middle School Teachers Regarding Differentiation Instruction, Karen Mclerran

Electronic Theses and Dissertations

The purpose of this qualitative phenomenological study was to examine the perceptions of middle school teachers regarding differentiation of instruction for students with mild to moderate disabilities. Although there has been little documentation in the literature regarding instructional differentiation five factors that facilitate change have been identified in the framework.

Data collection strategies included one-on-one semi-structured interviews and questionnaires. Analysis of data occurred in three phases: (a) transcribing interviews, (b) member checking of the transcripts, (c) coding-recoding of the data. The analysis of data was based on the theoretical proposition that student achievement, positive behaviors, and increased learner motivation fosters …

Borderline Personality Disorder And Violent Crime: The Moderating Role Of Sex And Race, Genevieve Allison

Electronic Theses and Dissertations

People receiving treatment for substance use disorders (SUD) are at risk of justice involvement. Although it is well-established that borderline personality disorder (BPD) increases risk for criminal involvement, it is unclear whether this relationship exists among people with SUDs. Furthermore, prior research has found sex and race differences in the relationships between BPD and justice involvement as well as violence, but these moderators have not been explored within a substance using sample. The current study utilized a sample receiving SUD treatment to examine whether BPD is associated with prior violent charges and, if race and sex moderated this relationship. Results …

Effect Of Metal Ions And Temperature On Stability Of Thiamine Determined By Hplc, Jhong Huei Huang

All Theses

Thiamine degradation occurs during storage and transportation for short and long periods due to the exposure to several factors, such as heat, oxidation-reduction reactions, and alkali. In this study, the effects of four metal ions (i.e., Cu⁺, Cu²⁺, Fe²⁺, and Fe³⁺) on thiamine stability in aqueous solutions at three temperatures (i.e., 25, 40, and 55°C) for the storage time of 7 days were discussed. Thiamine degradation was found to follow the first-order kinetic reaction, and the degradation rate could also be estimated. The factors in influencing thiamine stability included pH values, temperatures, …

The Serbian Orthodox Church As A Transnational Political Actor: A Case Study Of Regime Change In Montenegro, Dunja Arandjelovic

All Theses

Although many scholars have considered how religious institutions can affect democratic change, little attention has been given to the contemporary transnational potential of a church with a distinctively national identity. This study will explore the capacity of national churches to act transnationally by analyzing the Serbian Orthodox Church’s (SOC) recent political intervention in Montenegro, during which the church mobilized almost half of the Montenegrin population during the COVID pandemic in a movement that led to the defeat of Montenegro’s president in parliamentary elections for the first time in 30 years. My project is based on in-depth elite interviews with ten …

The Effects Of Tubulin Post-Translational Modifications On The Flagellar Motility Of Trypanosoma Brucei, Katherine Wentworth

All Theses

Trypanosoma brucei is a parasitic kinetoplastid that causes African trypanosomiasis and is transmitted to a mammalian host by the tsetse fly (Glossina spp.). T. brucei relies on its flagellar motility to carry out its morphological changes from the procyclic form (predominant in the fly vector) to the bloodstream form (infectious form in mammals) and navigate the bloodstream of its host. The driving structure within the flagellum is the axoneme, which is composed of microtubules and dynein motor proteins. The tubulin code hypothesis suggests that cells regulate microtubule motor protein activity through post-translational modifications (PTMs) of alpha and beta …

Evaluation Of Novel Management Options For Bacterial Spot Of Peach, Daniela Moreno

All Theses

Xanthomonas arboricola pv. pruni (Xap) is an economically important pathogen causing bacterial spot of stone fruits worldwide. In the southeastern US management for this disease relies on copper and oxytetracycline (OTC) sprays, yet disease incidence remains high especially when the environmental conditions are conducive (warm and rainy). To further complicate disease management copper tolerant and OTC resistant (OTC^R) strains of Xap have been reported in the southeastern peach orchards. complicating disease management. Therefore, we aim to evaluate potential chemical and biological alternatives for disease management. The first objective was to evaluate a novel nano nanoformulation Bz (Zinc Borate) …

Comparative Genome Analysis Of Plant Ascomycete Fungal Pathogens With Different Lifestyles Reveals Distinctive Virulence Strategies, Yansu Wang, Jie Wu, Jiacheng Yan, Ming Guo, Lei Xu, Liping Hou, Quan Zou

Department of Agronomy and Horticulture: Faculty Publications

Background: Pathogens have evolved diverse lifestyles and adopted pivotal new roles in both natural ecosystems and human environments. However, the molecular mechanisms underlying their adaptation to new lifestyles are obscure. Comparative genomics was adopted to determine distinct strategies of plant ascomycete fungal pathogens with different lifestyles and to elucidate their distinctive virulence strategies. Results: We found that plant ascomycete biotrophs exhibited lower gene gain and loss events and loss of CAZyme-encoding genes involved in plant cell wall degradation and biosynthesis gene clusters for the production of secondary metabolites in the genome. Comparison with the candidate effectome detected distinctive variations between …

Framework For The Use Of Extended Reality Modalities In Aec Education, Barbara Oliveira Spitzer, Jae Hoon Ma, Ece Erdogmus, Ben Kreimer, Erica Ryherd, Heidi Diefes-Dux

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The educational applications of extended reality (XR) modalities, including virtual reality (VR), augmented reality (AR), and mixed reality (MR), have increased significantly over the last ten years. Many educators within the Architecture, Engineering, and Construction (AEC) related degree programs see student benefits that could be derived from bringing these modalities into classrooms, which include but are not limited to: a better understanding of each of the subdisciplines and the coordination necessary between them, visualizing oneself as a professional in AEC, and visualization of difficult concepts to increase engagement, self-efficacy, and learning. These benefits, in turn, help recruitment and retention efforts …

Idiopathic Pulmonary Fibrosis And Lung Cancer: Future Directions And Challenges, Ahmad Abu Qubo, Jamil Numan, Juan Snijder, Maria Padilla, John H.M. Austin, Kathleen M. Capaccione, Monica Pernia, Jean Bustamante, Timothy O’Connor, Mary M. Salvatore

Einstein Health Papers

Idiopathic pulmonary fibrosis (IPF) is a progressive disease of pulmonary scarring. New treatments slow disease progression and allow pulmonary fibrosis patients to live longer. Persistent pulmonary fibrosis increases a patient’s risk of developing lung cancer. Lung cancer in patients with IPF differs from cancers that develop in the non-fibrotic lung. Peripherally located adenocarcinoma is the most frequent cell type in smokers who develop lung cancer, while squamous cell carcinoma is the most frequent in pulmonary fibrosis. Increased fibroblast foci in IPF are associated with more aggressive cancer behaviour and shorter doubling times. Treatment of lung cancer in fibrosis is challenging …

High Throughput And Highly Controllable Methods For In Vitro Intracellular Delivery, Justin Brooks, Grayson Minnick, Prithvijit Mukherjee, Arian Jaberi, Lingqian Chang, Horacio D. Espinosa, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

In vitro and ex vivo intracellular delivery methods hold the key for releasing the full potential of tissue engineering, drug development, and many other applications. In recent years, there has been significant progress in the design and implementation of intracellular delivery systems capable of delivery at the same scale as viral transfection and bulk electroporation but offering fewer adverse outcomes. This review strives to examine a variety of methods for in vitro and ex vivo intracellular delivery such as flow-through microfluidics, engineered substrates, and automated probe-based systems from the perspective of throughput and control. Special attention is paid to a …

Meningitis Post-Cochlear Implant And Role Of Vaccination, Ghadah A. Alanazi, Aumniyat S. Alrashidi, Khalid S. Alqarni, Saeed A. Al Khozym, Saad Alenzi

Saudi Medical Journal

Objectives: To investigate the incidence, risk factors, and management of meningitis in cochlear implant (CI)users. Methods: A systematic review was carried out using PubMed, Scopus, Web of Science, and Cochrane Central Register. Articles were considered relevant if reported any data on incidence, clinical presentations, the role of vaccination, management, and outcomes of meningitis after CI. Results: A total of 32 studies including 27358 patients were included, and meningitis was reported in only 202 cases. Meningitis occurred in the period ranging from 1 day to 72 months after CI. A total of 55 patients received the pneumococcal vaccine, while 20 patients …

Role And Mechanism Of Alpa1-Antitrypsin In Polycystic Ovary Syndrome, Shouxi Pan, Yilihaer Aizezi, Honglei Wang, Yingli Lu, Baigong Xue

Saudi Medical Journal

Objectives: To determine the relationships among alpha1-antitrypsin (A1AT), pro-inflammatory cytokines, neutrophil elastase (NE), interleukin (IL)- 1β, and IL-8 in cases with polycystic ovary syndrome (PCOS). Methods: Female rats in the control group were fed and watered normally. Female rats in the PCOS group were given high-fat diets and letrozole (1% carboxymethyl cellulose’ [CMC] solution) CMC by gavage at a dose of l mg/kg body weight daily for 23 days. The mRNA levels of A1AT and NE in rat ovaries were detected by performing real-time polymerase chain reaction (PCR) in the laboratory of Norman Bethune College of Medicine, Jilin University, China …

Identification Of Human Immunodeficiency Virus -1 E Protein-Targeting Lead Compounds By Pharmacophore Based Screening, Mazen M. Almehmadi, Alaa A. Shafie, Mamdouh Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem A. Almalki, Ahad Amer Alsaiari, Amal Adnan Ashour

Saudi Medical Journal

Objectives: To identify potential compounds by seeking the knowledge of molecular interactions between human immunodeficiency virus (HIV) glycoprotein (gp) 120 protein and anti-HIV drug (BMS-488043). Methods: This study is a computational structure-based drug design study, carried out at University of Taif, Saudi Arabia and African Genome Centre (AGC), Mohammed VI Polytechnic University, Benguerir, Morocco from January 2021 to March 2022. Initially, using the docked structure of gp120 with BMS-488043, a structure-based pharmacophore model was created. The generated model was utilized for virtual screening of the ZINC and ChemBridge database in order to identify hit compounds. To further assess the time-dependent …

The Role Of Laparoscopy In Emergency Colorectal Surgery, Nahar A. Alselaim, Haifa A. Altoub, Mohammed K. Alhassan, Raghad M. Alhussain, Abdullah A. Alsubaie, Farah A. Almomen, Abrar M. Almutairi

Saudi Medical Journal

Objectives: To assess the outcomes of the laparoscopic approach compared to those of the open approach in emergency colorectal surgery. Methods: This retrospective cohort study included all patients aged >15 years who underwent emergency colorectal surgery from 2016-2021 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Patients were divided based on the surgical approach into laparoscopic and open groups. Results: A total of 241 patients (182 open resections, 59 laparoscopic approaches) were included in this study. The length of stay in the intensive care unit was shorter in the laparoscopic than in the open group (1±3 days vs. 7±16 days). …

Incidence Of Peripancreatic Fluid Collections In Patients Presenting With Acute Pancreatitis, Nouran W. Molla, Abdullah H. Alsergani, Abduljabbar A. Alyamani, Majed A. Aljohani, Abdulaziz A. Aljohani, Fahad A. Alfaiz, Mohammed O. Alomar, Mohammed S. Binmayouf

Saudi Medical Journal

Objectives: To calculate the incidence of acute peripancreatic fluid collection (APFC) in patients with acute pancreatitis. The secondary objective is to determine the underlying etiologies of acute pancreatitis in the Saudi population. Methods: A retrospective cohort study was carried out at King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. The study analyzed data from patients who were diagnosed with acute pancreatitis between January 2008 and January 202. A total of 327 were included in the study after applying the inclusion and exclusion criteria. Their medical records were subsequently reviewed for the presence or absence of APFC on follow-up …