Digital Commons Network^™

Popdc1 Scaffolds A Complex Of Adenylyl Cyclase 9 And The Potassium Channel Trek-1 In Heart, Tanya A Baldwin, Yong Li, Autumn N Marsden, Susanne Rinné, Anibal Garza-Carbajal, Roland F R Schindler, Musi Zhang, Mia A Garcia, Venugopal Reddy Venna, Niels Decher, Thomas Brand, Carmen W Dessauer

Faculty, Staff and Student Publications

The establishment of macromolecular complexes by scaffolding proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for cardiac functions. We identify a novel AC scaffold, the Popeye domain-containing (POPDC) protein. The POPDC family of proteins is important for cardiac pacemaking and conduction, due in part to their cAMP-dependent binding and regulation of TREK-1 potassium channels. We show that TREK-1 binds the AC9:POPDC1 complex and copurifies in a POPDC1-dependent manner with AC9 activity in heart. Although the AC9:POPDC1 interaction is cAMP-independent, TREK-1 association with AC9 and POPDC1 is reduced upon …

Acetyl-Coa-Mediated Autoacetylation Of Fatty Acid Synthase As A Metabolic Switch Of De Novo Lipogenesis In Drosophila, Ting Miao, Jinoh Kim, Ping Kang, Hideji Fujiwara, Fong-Fu Hsu, Hua Bai

2020-Current year OA Pubs

De novo lipogenesis is a highly regulated metabolic process, which is known to be activated through transcriptional regulation of lipogenic genes, including fatty acid synthase (FASN). Unexpectedly, we find that the expression of FASN protein remains unchanged during

Future Newborns With Opioid-Induced Neonatal Abstinence Syndrome (Nas) Could Be Assessed With The Genetic Addiction Risk Severity (Gars) Test And Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (Kb220) As A Frontline Modality Instead Of Potent Opioids, Mauro Ceccanti, Mark S Gold, Et Al.

2020-Current year OA Pubs

In this nonsystematic review and opinion, including articles primarily selected from PubMed, we examine the pharmacological and nonpharmacological treatments of neonatal abstinence syndrome (NAS) in order to craft a reasonable opinion to help forge a paradigm shift in the treatment and prevention of primarily opioid-induced NAS. Newborns of individuals who use illicit and licit substances during pregnancy are at risk for withdrawal, also known as NAS. In the US, the reported prevalence of NAS has increased from 4.0 per 1000 hospital births in 2010 to 7.3 per 1000 hospital births in 2017, which is an 82% increase. The management of …

‘Making Up For Lost Time’: Neoliberal Governance And Educational Catch-Up Measures For Disadvantaged Students During The Covid-19 Pandemic, B Gross, P Kelly, S Hofbauer

Plymouth Institute of Education

The neoliberal governance of education and the import of values such as economic productivity are changing schools in Europe to different degrees. Understanding the effects of this on disadvantaged students is especially critical during and after the COVID-19 pandemic, given their greater need for catch-up support. In this paper we analyse national government policy guidelines and reports concerning catch-up measures in Italy, Germany and England and illuminate debates between various actors using news and education media reports. We find that while catch-up measures in the studied countries promote equality of access, for instance through extending schooling to make up for …

Urban Green Roofs Can Support A Diversity Of Parasitoid Wasps, Aramee C. Diethelm, Susan Masta

Biology Faculty Publications and Presentations

Green roofs are often installed atop buildings to provide ecological services such as mitigating storm water runoff and cooling air within urban heat islands. We found that green roofs in Portland, Oregon, also can support biodiversity, including a diverse assemblage of parasitoid wasps, with 20 morphospecies from 10 families present on the four roofs we surveyed. The roofs with greater plant diversity and structural complexity harbored comparatively more parasitoid morphospecies than the structurally simpler Sedum-dominated roofs. The oldest green roof supported much greater diversity than the younger roofs, including a comparably planted roof three times its size. Parasitoid wasps from …

The Rheumatoid Arthritis Drug Auranofin Lowers Leptin Levels And Exerts Antidiabetic Effects In Obese Mice, Aaron R Cox, Peter M Masschelin, Pradip K Saha, Jessica B Felix, Robert Sharp, Zeqin Lian, Yan Xia, Natasha Chernis, David A Bader, Kang Ho Kim, Xin Li, Jun Yoshino, Xin Li, Gang Li, Zheng Sun, Huaizhu Wu, Cristian Coarfa, David D Moore, Samuel Klein, Kai Sun, Sean M Hartig

Faculty, Staff and Student Publications

Low-grade, sustained inflammation in white adipose tissue (WAT) characterizes obesity and coincides with type 2 diabetes mellitus (T2DM). However, pharmacological targeting of inflammation lacks durable therapeutic effects in insulin-resistant conditions. Through a computational screen, we discovered that the FDA-approved rheumatoid arthritis drug auranofin improved insulin sensitivity and normalized obesity-associated abnormalities, including hepatic steatosis and hyperinsulinemia in mouse models of T2DM. We also discovered that auranofin accumulation in WAT depleted inflammatory responses to a high-fat diet without altering body composition in obese wild-type mice. Surprisingly, elevated leptin levels and blunted beta-adrenergic receptor activity achieved by leptin receptor deletion abolished the antidiabetic …

Tele-Medicine Based And Self-Administered Interactive Exercise Program (Tele-Exergame) To Improve Cognition In Older Adults With Mild Cognitive Impairment Or Dementia: A Feasibility, Acceptability, And Proof-Of-Concept Study, Catherine Park, Ram Kinker Mishra, Michele K York, Ana Enriquez, Abigail Lindsay, Gregory Barchard, Ashkan Vaziri, Bijan Najafi

Center on Aging Staff Publications

Improved life expectancy is increasing the number of older adults who suffer from motor-cognitive decline. Unfortunately, conventional balance exercise programs are not tailored to patients with cognitive impairments, and exercise adherence is often poor due to unsupervised settings. This study describes the acceptability and feasibility of a sensor-based in-home interactive exercise system, called tele-Exergame, used by older adults with mild cognitive impairment (MCI) or dementia. Our tele-Exergame is specifically designed to improve balance and cognition during distractive conditioning while a telemedicine interface remotely supervises the exercise, and its exercises are gamified balance tasks with explicit augmented visual feedback. Fourteen adults …

Eye Closure Interacts With Music To Influence Vividness And Content Of Directed Imagery, Steffen A. Herff, Sophie Mcconnell, Julie L. Ji, Jon B. Prince

School of Psychology

Goal-directed, intentional mental imagery generation supports a range of daily self-regulatory activities, such as planning, decision-making, and recreational escapism. Many clinical interventions for mood and anxiety disorders also use imagery and their effectiveness can be affected by an individual's ability to manipulate vividness and content of mental imagery. Prior literature points towards music as a promising candidate to influence imagination in such settings, but basic questions remain regarding how music affects mental imagery and how it interacts with basic, well-established parameters, such as facilitatory effects of eye closure. One hundred participants listened to music and a silent control whilst performing …

Nanoclays And Curcumin Based Food Packaging Material For Intelligent Food Packaging Applications, Kalpani Y. Perera, Swarna Jaiswal, Amit K. Jaiswal, Shubham Sharma

Articles

Bionanocomposite packaging eco-friendly alternatives with enhanced characteristics. This study aimed to develop a bionanocomposite intelligent packaging. Sodium alginate, gelatin, Curcumin (Cur), glycerol, and Nanoclay (NC) films were prepared. The influences of nanoclay and curcumin on the surface, optical, mechanical, chemical, barrier, and pH-indicating properties were studied. The results showed that the lightness of films was reduced by 1.28 folds compared to NC (control) film, while the yellowness of films increased by 5.82 folds. Film transparency was reduced by 9.3 folds and a 3.46 folds increase in UV barrier properties was observed compared to NC (control) film. The highest tensile strength …

Unfavorable Social Determinants Of Health Are Associated With Higher Burden Of Financial Toxicity Among Patients With Atherosclerotic Cardiovascular Disease In The Us: Findings From The National Health Interview Survey, Javier Valero-Elizondo, Zulqarnain Javed, Rohan Khera, Mauricio E Tano, Ramzi Dudum, Isaac Acquah, Adnan A Hyder, Julia Andrieni, Garima Sharma, Michael J Blaha, Salim S Virani, Ron Blankstein, Miguel Cainzos-Achirica, Khurram Nasir

Faculty, Staff and Students Publications

• D: PMC9727868

A Synopsis Of Institutional Repositories In Nigerian University System: Advantages And Challenges, Samson Adesina Akinola, Dolapo P. Olagoke, Opeyemi F. Opawale

Library Philosophy and Practice (e-journal)

The academic communities have undoubtedly been struggling for some years now with difficulties in disseminating and communicating research findings. This is as a result of the ever increasing high cost of journals, which are the traditional medium for research communication and how this as affected libraries budget, most especially in the depressed economy of developing countries. The financial difficulties being experienced by academic publishers have also added to this pain. Many academics have their research work stored in Microsoft (MS) words and other digital formats on their computers, but only very few of them ponder on the long term preservation …

Identification Of Acenkps, A Committed Common Progenitor Population Of The Ilc1 And Nk Cell Continuum, Noe Rodriguez-Rodriguez, Paula A Clark, Mayuri Gogoi, Ana C F Ferreira, Bernhard Kerscher, Alastair Crisp, Helen E Jolin, Jane E Murphy, Meera Sivasubramaniam, Luisa Pedro, Jennifer A Walker, Morgan W D Heycock, Jacqueline D Shields, Jillian L Barlow, Andrew N J Mckenzie

Faculty, Staff and Student Publications

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage-Id2+IL-7Rα+CD25-α4β7-NKG2A/C/E+Bcl11b-. In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2-/-Il2rg-/- hosts, aceNKPs give rise to a spectrum of mature ILC1/NK cells …

Data Analysis Processes And Techniques For Validation Of Wearable Technology: An Example, Bryson Carrier, James W. Navalta

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 10, 2022. With wearable technology growing in popularity and sophistication, there remains a need to determine the validity of these devices by independent observers. Validation studies of wearable technology can involve large amounts of data, with data preparation techniques that are not always clearly established. This can make attempts to reproduce the results difficult and does not allow researchers to gain guidance in how to perform their own analyses if they wanted to perform a similar study. Therefore, this paper details the process that was utilized to prepare and …

A Statistical Machine Learning Method To Handle Missing Phq-8 Score Data In The Uaehfs Pilot Data – A Bayesian Network Approach, Mitha Al Balushi, A. Ahmad, S. Javaid, L. Ahmed, M. Grivna, F. Al Maskari, A. Abdulle, R. Ali

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Pathway-Based Analysis And Artificial Intelligence Reveals Metabolic Subtypes Of Clinical Relevance In Breast Cancer, Mohammad Askandar Iqbal

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Role Of Artificial Intelligence For Self-Triage Systems Of Safe Increase Of Ambulance Resource Efficiency, Tanveer Ahmed Yadgir, Tamas Madl, Omer Al Sakaf

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

An Artificial Intelligence (Ai) Model For Prediction Of Covid 19 Infection Risk In The Uae Population, Sara Alshaya, Sheik Abdullah Jamal Mohideen, Aji Gopakumar, Vibhor Mathur

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Evaluation Of Rotenone Mediated Α-Synuclein Spreading And Neurotoxicity In Α-Synuclein Pff Induced Animal Model Of Parkinson’S Disease, Engila Khan, Mustafa Ardah, M. Emdadul Haque

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Impact Of Working During Covid19 On The Mental Health Of Health Care Workers In A Hospital In Sharjah, Uae, Jayakumary Muttappallymyalil, Shaikha Fawaghi Almualla

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Drug Development Against Covid-19, Wael M. Rabeh, Juliana C. Ferreira, Samar Fadl

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Cervical Muscle Strength And Kinematics During An Unanticipated Perturbation In University Aged Male And Female Rugby Athletes, Abigail Ruppert, Lauren J. Lattimer

Journal for Sports Neuroscience

Introduction: Female athletes participating in contact sports demonstrate a concussion injury risk factor that is two times greater than their age-matched male counterparts. Recent literature has outlined the importance of neck muscle strength and neuromuscular characteristics in the mitigation of excessive head kinematics. Rugby is a contact sport in which tackles comprise the mechanism for concussion, which is caused by inertial impacts. Females exhibit higher measurements of acceleration and investigating potential gender differences in dynamic stabilization of the head is warranted in rugby. Methods: Twenty-three (15 female, 8 male) university-aged rugby athletes participated in kinematic analysis; and a series of …

Ace2 Variation And Trafficking In The Pathogenesis Of Sars-Cov-2, Nesreen Al-Khofash

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Post-Vaccination Induced-Immune Response To Anti-Sars-Cov-2 Igg Antibodies And T-Cells Surrogate Markers By Type And Vaccination Regime: A Retrospective Cohort Study, R. H. Al-Rifai, F. Al Housani, R.M. Abuyadek, S. Atef, J. Donnelly, A. Jabari, L. A. Ahmed, B. Altrabulsi, A. Alatoom, A. Al Suwaidi, L. Abdelwareth

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Impact Of A Free-Choice (‘Genius Time’) Inquiry Project On Student Skill-Building, Agency, And Motivation, Sam Woolford

i.e.: inquiry in education

Student investment in learning is often stronger when learning incorporates student choice, ‘real-world’ authenticity, and creativity. This action research investigated the impact of a particular tool for emphasizing these elements in learning: A free-choice, or ‘Genius Time,’ project in which middle school students in an independent all-boys school were asked to develop and carry out an individual project to investigate anything of their choosing, as part of their regular science class. This study aimed to determine how a project like this could impact student skill-building, self-efficacy, motivation, and student learning through the practice of inquiry. Through surveys, student self-assessment, student …

A Retrospective Chart Review Of Pediatric Complicated Community-Acquired Pneumonia: An Experience In The Al Qassimi Women And Children Hospital, Sinan Yavuz, Amal Sherif, Maryam Amirrad, Khalid Sabet, Mohamed Hassan, Motasem Abuelreish, Noura Langawi, Mina Almanasir, Nader Francis

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Phactr1 & Lpl Mediate Restenosis Risk In Cad Patients, Cynthia Al Hageh, Stephanie Chacar, Thenmozhi Vankatchalam, Dominique Gauguier, Antoine Abchee, Elie Chammas, Hamdan Hamdan, Sioban O'Sullivan O'Sullivan, Pierre Zalloua, Moni Nader

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

The Role Of Bcl3 Dysregulation In The Pathogenesis Of Asthma And Lung Cancer, Laila Salameh, Poorna Manasa Bhamidimarri, Noha Elemam, Rakhee K. Ramakrishnan, Qutayba Hamid, Bassam Mahboub, Saba Al Heialy, Rifat Hamoudi

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

The Mutaba’Ah Study: A Cohort Profile Of The Largest Mother And Child Cohort Study In The United Arab Emirates, Luai A. Ahmed, Zufishan Alam, Iffat Elbarazi, Fatima Al-Maskari, Rami H. Al-Rifai, Tom Loney

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Saudi Heart Association Guidelines On Best Practices In The Management Of Chronic Coronary Syndromes, Owayed Alshammeri, Shukri Al Saif, Halia Al Shehri, Mirvat Alasng, Fatema Qaddoura, Mohammad Al Shehri, Yosra Turkistani, Adel Tash, Walid Alharbi, Fahad Al Qahtani, Rafael Diaz, Wael Mahaimeed, Waleed Al Habeeb, Khalid Alfaraidy

Journal of the Saudi Heart Association

Background: The prevalence of both chronic coronary syndrome (CCS) and its risk factors is alarming in Saudi Arabia and only a minority of patients achieve optimal medical management. Context-specific CCS guidelines outlining best clinical practices are therefore needed to address local gaps and challenges. Consensus panel: A panel of experts representing the Saudi Heart Association (SHA) reviewed existing evidence and formulated guidance relevant to local clinical practice considering the characteristics of the Saudi population, the Saudi healthcare system, its resources and medical expertise. They were reviewed by external experts to ensure scientific and medical accuracy. Consensus findings: Recommendations are provided …

مسؤولية وزير التعليم عن العودة للمدراس في ظل أزمة فيروس كورونا المستجد- كوفيد 19-: دراسة فقهية معاصرة The Responsibility Of The Minister Of Education For Returning To Schools In Light Of The Emerging Crisis Of Covid-19: A Contemporary Jurisprudence Study, Huda Hamad Salem

Jordan Journal of Islamic Studies

جاء هذا البحث ليجيب عن سؤال: هل وزير التعليم مسؤول فعلا عن ما قد يصاب به الطلبة من ضرر إذا عادوا لمدارسهم؟

من خلال التعريف بأثر فيروس كورونا على الجوانب التعليمية، وبيان أركان الضمان وتنزيل ما قرره علماؤنا من أقوال وآراء متعلقة بالموضوع على تصرفات الوزير.

وذلك باتباع المنهج الاستقرائي الوصفي الذي يلائم محتوى البحث، ثم اتباع المنهج الاستنباطي في بيان الحكم الشرعي لسؤال البحث.

وقد توصل البحث إلى أن قرار التعطيل إنما صدر من مجلس الوزراء، وفق خطة مرسومة خاضعة لتقدير السلطات الصحية، فكان الوزير متسبباً لا مباشراً، فلا ضمان عليه إنما الضمان بالتعدي، ولما كان العلم هو الركن …