Digital Commons Network^™

Social Attention During Object Engagement: Toward A Cross-Species Measure Of Preferential Social Orienting, Claire Weichselbaum, Nicole Hendrix, Jordan Albright, Joseph D Dougherty, Kelly N Botteron, John N Constantino, Natasha Marrus

2020-Current year OA Pubs

BACKGROUND: A central challenge in preclinical research investigating the biology of autism spectrum disorder (ASD) is the translation of ASD-related social phenotypes across humans and animal models. Social orienting, an observable, evolutionarily conserved behavior, represents a promising cross-species ASD phenotype given that disrupted social orienting is an early-emerging ASD feature with evidence for predicting familial recurrence. Here, we adapt a competing-stimulus social orienting task from domesticated dogs to naturalistic play behavior in human toddlers and test whether this approach indexes decreased social orienting in ASD.

METHODS: Play behavior was coded from the Autism Diagnostic Observation Schedule (ADOS) in two samples …

Single Cell Rna Sequencing Of The Adult Drosophila Eye Reveals Distinct Clusters And Novel Marker Genes For All Major Cell Types, Kelvin Yeung, Komal Kumar Bollepogu Raja, Yoon-Kyung Shim, Yumei Li, Rui Chen, Graeme Mardon

Faculty, Staff and Students Publications

The adult Drosophila eye is a powerful model system for phototransduction and neurodegeneration research. However, single cell resolution transcriptomic data are lacking for this tissue. We present single cell RNA-seq data on 1-day male and female, 3-day and 7-day old male adult eyes, covering early to mature adult eyes. All major cell types, including photoreceptors, cone and pigment cells in the adult eye were captured and identified. Our data sets identified novel cell type specific marker genes, some of which were validated in vivo. R7 and R8 photoreceptors form clusters that reflect their specific Rhodopsin expression and the specific Rhodopsin …

Advice From One Patient To Another: Qualitative Analysis Of Patients' Perspectives About Chemotherapy Initiation, Catalina Malinowski, Edna Paredes, Ashley J Housten, Mariana Chavez-Macgregor

2020-Current year OA Pubs

PURPOSE: Although the association between delays in (neo)adjuvant chemotherapy initiation and adverse outcomes is well-documented, patient perspective regarding the lived experience among those with breast cancer delay is sparse. Project Start was a qualitative study designed to assess and identify the multilevel factors contributing to the barriers and facilitators of initiating chemotherapy. This report explores specific responses where patients with breast cancer provide insight and advice for newly diagnosed women on preparing for chemotherapy initiation and informs potential interventions to facilitate timely chemotherapy initiation.

PATIENTS AND METHODS: Women diagnosed with primary invasive breast cancer who experienced a ≥60-day delay in …

The Cholera-Fiend: Cheap Fiction, Medical Professionals, And Entertainment, Sariah Fales Harrington

Theses and Dissertations

First published in 1849, Charles Averill’s The Cholera-Fiend follows three villains as they attempt to artificially propagate cholera for their own villainous purposes in New York City. Gumbo, a Black servant to one of the villains, is meant to be the humorous relief in the text, but Gumbo experiences a calculated dehumanization from human to disabled, which causes him to be more at-risk for a health crisis—such as a tapeworm or cholera—than his white counterparts. Through analyzing the genre of cheap fiction, the views of medical professionals towards Black bodies, and other ways Black bodies were used as entertainment, I …

Kalamazoo County Housing Plan, Emily Petz, Lee Adams, Gerrit Anderson, Dakota Mccracken, Brian Pittelko

Reports

A healthy housing continuum provides homes for those in a range of incomes or in different life situations. Kalamazoo County has a shortage of housing units at multiple price points. Low rates of construction, high construction costs, increased demand from a growing population, and housing costs that are increasing faster than wages have contributed to the shortage and affordability issues. Fortunately, many strategies are available to help alleviate some of the housing concerns found in the county. These strategies are most effective when community partners band together and implement them as a cohesive unit.

Music Therapy Interventions And Their Outcomes On Hematology And Oncology Patients, And Outpatient Groups, Alexandra Paque

Honors Theses

There is a variety of research published about the use of music therapy interventions and their outcomes for the pediatric hematology-oncology and outpatient groups, however the research is not combined to put together a description of the most effective interventions utilized in one place. This scoping review addressed the questions of what music therapy interventions are used in the pediatric hematology/oncology and outpatient settings, and what the outcomes of music therapy were respectively. Inclusion and exclusion criteria were established to determine what articles to include in the review. Three databases including Google Scholar, WMU Library, and PubMed were searched to …

Office Of Research, Economic Engagement And Outreach Update, December 14, 2022, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Investigating The Relationships Between Concentrated Disadvantage, Place Connectivity, And Covid-19 Fatality In The United States Over Time, Fengrui Jing, Zhenlong Liu, Shan Qiao, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background Concentrated disadvantaged areas have been disproportionately affected by COVID-19 outbreak in the United States (US). Meanwhile, highly connected areas may contribute to higher human movement, leading to higher COVID-19 cases and deaths. This study examined the associations between concentrated disadvantage, place connectivity, and COVID-19 fatality in the US over time. Methods Concentrated disadvantage was assessed based on the spatial concentration of residents with low socioeconomic status. Place connectivity was defined as the normalized number of shared Twitter users between the county and all other counties in the contiguous US in a year (Y = 2019). COVID-19 fatality was measured …

The Effect Of Gut Microbiota On Overwintering Success In Mule Deer, Emma Wilcox

Theses and Dissertations

Mule deer are an important rangeland grazer, large prey species, and game animal for the state of Utah, so herd size is monitored and managed actively. A significant cause of population decline is poor overwintering survival, including from the lack of available forage during winter months. Mule deer energy storage is correlated with greater overwintering success, so physical estimates of energy storage including body condition score (BCS), rump fat (RF), and loin thickness (LT), can be used to track and predict a herd's health. Current methods of collecting deer information are costly, time consuming, and cause physical stress to deer, …

Wildfire Modeling With Data Assimilation, Andrew Johnston

Theses and Dissertations

Wildfire modeling is a complex, computationally costly endeavor, but with droughts worsening and fires burning across the western United States, obtaining accurate wildfire predictions is more important than ever. In this paper, we present a novel approach to wildfire modeling using data assimiliation. We model wildfire spread with a modification of the partial differential equation model described by Mandel et al. in their 2008 paper. Specifically, we replace some constant parameter values with geospatial functions of fuel type. We combine deep learning and remote sensing to obtain real-time data for the model and employ the Nelder-Mead method to recover optimal …

Future Climate Rhetorics Of Belize: A Counter-Apocalyptic Inquiry Into Belize’S Possible, Probable, And Preferable Futures, André Habet

Dissertations - ALL

This dissertation investigates future climate rhetorics of Belize through a variety of methods in order to mediate the various conceptions of the future professed in climate policy, experiential phenomenology, and acoustic ecologies of agroecology. Chapter one considers the values embedded in climate change policy documents, specifically the Nation Communications documents composed by Belize’s various ministries since the country signed to the Paris Agreement in 2016. Using the People’s Agreement of Cochamba as an alternative lens, the chapter explores how people-centered, as opposed to market-centered, attunements informing climate policy can potentially lead to a more just, equitable future that does not …

Unclean And Unforgivable, Cindy Pope

Master of Arts in Professional Writing Capstones

Abstract

Unclean and Unforgiveable

Unclean and Unforgiveable is a historical medical drama wherein the protagonist, Victoria Evans, travels to Richmond, Virginia, to become a nurse trainee in 1862. Using archival and bibliographic research, this writer constructed authoritative, realistic, and emotionally charged scenes for readers to experience the brutalities of war and the harsh realities of nursing in the South. Yet for all her laborious duties carried out with diligence and devotion, Victoria’s beloved Virginia is decimated, and her family is destroyed. Her one marketable skill is nursing using proper hygienic and cleansing techniques. This brings her to the attention of …

A Comparative Study On Blockchain-Based Electronic Health Record Systems: Performance, Privacy, And Security Between Hyperledger Fabric And Ethereum Frameworks, Md Jobair Hossain Faruk, Hossain Shahriar, Maria Valero, Xia Li

Master of Science in Software Engineering Theses

Traditional data collection, storage, and processing of Electronic Health Records (EHR) utilize centralized techniques that pose several risks of single point of failure and lean the systems to a number of internal and external data breaches that compromise their reliability and availability. Addressing the challenges of conventional database techniques and improving the overall aspects of EHR application, blockchain technology is being evaluated to find a possible solution. Blockchain refers to an emerging distributed technology and incorruptible database of records or digital events which execute, validate, and maintain by a ledger technology to provide an immutable architecture and prevent records manipulation …

Investigating Biometrics Of Perimyotis Subflavus In Traditional And Nontraditional Hibernacula In The Southeastern United States As It Relates To Susceptibility To White-Nose Syndrome., Makayla Ferrari

Master of Science in Integrative Biology Theses

Perimyotis subflavus, or tricolored bat, populations have declined significantly since the emergence of white-nose syndrome (WNS) and has been proposed for listing as “endangered” under the United States Endangered Species Act. Traditionally, bats use caves as hibernacula, but as anthropogenic impacts have increased so has the use of manmade structures like culverts and bridges for roosting by several bat species. The internal environment of these anthropogenic structures is influenced by external temperature and humidity differently than caves and may influence P. subflavus winter activity, and thus susceptibility to WNS. One of the most significant differences in P. subflavus roosting behavior …

F3rn.Org Defi, Nabeel Mohammed Basheer

Theses

Leadership is searching for strategies to assist geo-based communities, cities, large and small towns, and neighborhoods in achieving independent and more decentralized, sustainable environmental practices. By employing a paradigm that encourages peer-to-peer fund raising and rewards participants by actively encouraging more civic engagement, the F3rn platform responds to this demand and helps to build a stronger local circular economy. The F3rn Defi Platform has made it possible to create a global ecosystem for recycling plastic waste. This ecosystem uses Algorand blockchain technology to provide unbanked people with access to financial services, job opportunities for the extremely poor through financial incentives, …

Interprofessional Education Lab Manual And Workbook, Geraldine Terry

Open Textbooks

This laboratory manual was designed to educate and develop integrated healthcare practices essential in delivering person-centered care. Participants will develop their ability to distinguish the role of their own profession and other healthcare professionals collaborating in the care coordination and case management of patients. The content and team-oriented activities in this manual provide guidance on advancing leadership and communication principles necessary for effective interprofessional communication and team collaboration. The well-researched material is tailored to build on the strengths of participants, while also identifying and encouraging areas for improvement.

How Do You Initiate A Weight Discussion With Your Patients?, Alexander Redmann, Rachael Urbaniak, Jessica Neuman

DNP and Student Works

Research shows that many providers feel uncomfortable initiating weight discussions related to fear of sounding judgemental and inexperience in weight counseling. This leads to the failure of healthcare providers to intervene before weight issues become a greater diagnosis. The primary objective for this project is to determine if a screening tool aids providers in initiating weight discussions with patients.

Implementation Of Frostbite And Opioid Overdose Response Guidelines At A Warming Center, Kristeljei Baltazar, Rachel Turner

DNP and Student Works

Homelessness is a major crisis within the United States. The instability of the homeless population's lifestyle exposes them to physical and mental health conditions such as frostbite and opioid use. Due to the harsh winter weather conditions in Minnesota, homeless individuals often experience frostbite. In addition, opioid overdoses continue to rise within this community, with numbers doubling each year. The purpose of this project was to increase staff and volunteer knowledge and confidence levels surrounding the response to frostbite injuries and opioid overdoses by implementing guidelines at a warming center for homeless individuals.

The Culture War Over Girls' Sports: Understanding The Argument For Transgender Girls' Inclusion, Kimberly A. Yuracko

Villanova Law Review (1956 - )

No abstract provided.

Too Narrow, Too Bad: A Loophole The Adam Walsh Act Did Not Foresee In United States V. Icker, Sophie Davish

Villanova Law Review (1956 - )

No abstract provided.

Pyrvinium Pamoate: Past, Present, And Future As An Anti-Cancer Drug, Christopher W Schultz, Avinoam Nevler

Department of Surgery Faculty Papers

Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some polyaminopyrimidines and mitochondrial-targeting peptoids, has been linked with mitochondrial localization and targeting. Over the past two decades, increasing evidence has emerged showing pyrvinium to be a strong anti-cancer molecule in various human cancers in vitro and in vivo. This efficacy against cancers has been attributed to diverse mechanisms of action, with the weight of evidence supporting the inhibition of mitochondrial function, the WNT pathway, and cancer stem cell renewal. …

St. Joseph County 2021 Housing Plan, Molly Trueblood, Lee Adams, Gerrit Anderson, Southcentral Michigan Planning Council

Reports

No abstract provided.

The Free College Handbook: A Practitioner’S Guide To Promise Research, Michelle Miller-Adams Co-Editor, Jennifer Iriti Co-Editor, Elizabeth Bell, Meredith S. Billings, Kathleen Bolter, Celeste Carruthers, Daniel Collier, Gresham D. Collom, Denisa Gándara, Douglas N. Harris, Brad J. Hershbein, Amy Li, Danielle Lowry, Lindsay C. Page, Bridget Timmeney

Reports

No abstract provided.

Montcalm And Ionia Counties Housing Plan, Emily Petz, Lee Adams, Gerrit Anderson, Dakota Mccracken, Brian Pittelko, W.E. Upjohn Institute For Employment Research

Reports

No abstract provided.

Midweek Memo, Georgia Southern University

Midweek Memo

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Law And Indigenous Religion: Theorizing A Complex Relationship, Kristen Elizabeth Lewis

LLM Theses

This thesis asks what preconditions are necessary to think the relation between law and Indigenous religion without marginalizing perspectives, such as those germane to Indigenous religion, that fall outside law’s frame (often figured, erroneously, as ‘objective’ and ‘neutral’). The research grounds itself in the only Supreme Court of Canada case that, to date, has involved Indigenous religious freedoms and s. 2(a) of the Canadian Charter of Rights and Freedoms (Ktunaxa Nation v British Columbia 2017 SCC) and in the very few lower court decisions that have followed in its not-unproblematic wake. Inspired by several currents of both Indigenous thought and …

Addressing The Drug Problem: The Establishment Of Drug Courts And Evaluating Their Effectiveness, Diana Blick

Theses

Throughout the United States during the past few decades, there have been problems with the use of drugs. There has and always have been issues with drug addiction and drug crimes in terms of how to address those problems. From the harsh consequences of the Rockefeller Drug laws in 1973 to the establishment of the first drug court in 1989, there have been reforms to the drug laws to reduce the severity for punishments of drug offenses. The first drug court in the United States was established in Miami, Florida before spreading throughout the United States. The first drug court …

Barriers To Healthcare And Their Relationship To Well-Being And Social Support For Autistic Adults During Covid-19, Charlotte Featherstone, Richard A. Sharpe, Nick Axford, Sheena Asthana, Susan Ball, Kerryn Husk

Peninsula Medical School

Aim: The present study aimed to investigate barriers to healthcare and their relationships to social and emotional well-being and intersectional inequalities for autistic adults during COVID-19 restrictions in the UK. Background: Autistic adults experience severe health inequalities and report more barriers to accessing health services compared to other both disabled and non-disabled populations. The COVID-19 pandemic has impacted many areas of society that may have increased vulnerability of autistic people to social and health inequalities, including delivery of healthcare from in-person to remote methods. Method: One hundred twenty-eight autistic adults who lived in the UK took part in an online …

Utilizing An Α,Β-Unsaturated Dicarboxylic Acid For A Defect Initiated Residue Removal During Cu Post-Chemical Mechanical Planarization Cleaning, Abigail L. Dudek, Kiana A. Cahue, Adam T. Caridi, Tatiana R. Cahue, Jason J. Keleher

Chemistry Department Faculty Articles

The development of post-Chemical Mechanical Planarization (p-CMP) cleaning processes is critical for the continued miniaturization of Integrated Circuit (IC) and logic device architecture. In order for further extension of Moore’s Law the minimization of critical defects is essential. This work focuses on the development of surface-active cleaning chemistries via the implementation of an α, β-unsaturated dicarboxylic acid additive to create synergy at the liquid-brush-wafer interface. More specifically, the implementation of Itaconic Acid (ItA) will chemically activate an organic residue (i.e., Cu(I)-BTA film) resulting in effective removal at significantly reduced CoF. This work demonstrates that the conjugated structure present in ItA …

A Gating Lever And Molecular Logic Gate That Couple Voltage And Calcium Sensor Activation To Opening In Bk Potassium Channels, Liang Sun, Frank T Horrigan

Faculty, Staff and Students Publications

BK channels uniquely integrate voltage and calcium signaling in diverse cell types through allosteric activation of their K+-conducting pore by structurally distinct V and Ca2+ sensor domains. Here, we define mechanisms and interaction pathways that link V sensors to the pore by analyzing effects on allosteric coupling of point mutations in the context of Slo1 BK channel structure. A gating lever, mediated by S4/S5 segment interaction within the transmembrane domain, rotates to engage and stabilize the open conformation of the S6 inner pore helix upon V sensor activation. In addition, an indirect pathway, mediated by the carboxyl-terminal cytosolic domain (CTD) …