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2022

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Laterally Heterogeneous Seismic Anisotropy Investigated By Shear Wave Splitting Analyses, Yan Jia Jan 2022

Laterally Heterogeneous Seismic Anisotropy Investigated By Shear Wave Splitting Analyses, Yan Jia

Doctoral Dissertations

"Numerous geophysical studies suggest that seismic anisotropy is a nearly ubiquitous property of the Earth’s crust and upper mantle. In this study, we utilize the shear wave splitting technique to investigate the piercing-point-dependent azimuthal anisotropy beneath the northeastern edge of the Sichuan Basin in central China, and the spatial and temporal variations of anisotropy near the 2019 M7.1 Ridgecrest earthquake in California, respectively. A clear back azimuthal dependence of the splitting parameters and the lack of a 90° or 180° periodicity of azimuthal variation in the observed fast orientations provide strong evidence for the existence of piercing-point-dependent anisotropy beneath the …


Application Of Machine Learning In Geophysics: Ranking Teleseismic Shear Wave Splitting Measurements And Classifying Different Types Of Earthquakes, Yanwei Zhang Jan 2022

Application Of Machine Learning In Geophysics: Ranking Teleseismic Shear Wave Splitting Measurements And Classifying Different Types Of Earthquakes, Yanwei Zhang

Doctoral Dissertations

"During the past decades, applications of Machine Learning have been explosively developed to solve various academic and industrial problems, and over-human performance has been shown in diverse areas. In geophysical research, Machine Learning, especially Convolutional Neural Network (CNN), has been applied in numerous studies and demonstrated considerable potential. In this study, we applied CNN to solve two geophysical problems, ranking teleseismic shear splitting (SWS) measurements and classifying different types of earthquakes.

For ranking teleseismic SWS measurements, we utilized a CNN-based method to automatically select reliable SWS measurements. The CNN was trained by human-verified teleseismic SWS measurements and tested using synthetic …


Mantle Flow And Transition Zone Discontinuities Beneath The Carribean Plate: Constraints From Shear Wave Splitting And Receiver Function Analyses, Tu Xue Jan 2022

Mantle Flow And Transition Zone Discontinuities Beneath The Carribean Plate: Constraints From Shear Wave Splitting And Receiver Function Analyses, Tu Xue

Doctoral Dissertations

"Azimuthal anisotropy quantified by teleseismic SKS, SKKS, PKS (“XKS”) and local S wave splitting parameters is used to investigate lithospheric deformation and asthenospheric flow beneath the boundary zone of the North American and Caribbean plates and adjacent areas. A total of 4915 XKS and 1202 pairs of local S wave splitting parameters were obtained at 24 broad band seismic stations. The XKS observations can be divided into two groups based on the spatial distribution of the resulting fast polarization orientations. Those observed on the Caribbean Plate are mostly WNW-ESE which are roughly trench-parallel. In contrast, the fast orientations observed on …


Strain And Temperature Measurement From Distributed Fiber Optic Sensors In Performance-Based Fire Engineering, Yanping Zhu Jan 2022

Strain And Temperature Measurement From Distributed Fiber Optic Sensors In Performance-Based Fire Engineering, Yanping Zhu

Doctoral Dissertations

"Strain and temperature measurement of steel and concrete structures under fires is critical to the understanding of structural performance yet historically challenging due to a significant gap in measurement science. This Ph.D. study characterizes in six parts low-cost distributed fiber optic sensors and applies them to strain, and temperature measurements based on Rayleigh and Brillouin light scattering. The first part aims to quantify the Rayleigh scattering based measurement accuracy of distributed fiber optic sensors under a heating-holding load protocol and characterize the effect of polymer coating on the sensors as the polymer softens and melts at elevated temperatures. The second …


Far-End Crosstalk Modeling And Prediction For High-Speed Pcb Design With Inhomogeneous Dielectric Layers (Idls), Yuanzhuo Liu Jan 2022

Far-End Crosstalk Modeling And Prediction For High-Speed Pcb Design With Inhomogeneous Dielectric Layers (Idls), Yuanzhuo Liu

Doctoral Dissertations

"Far-end crosstalk (FEXT) noise is a critical factor that affects signal integrity performance in high-speed systems. The FEXT level is sensitive to the inhomogeneity of the dielectric layers in fabricated printed circuit boards (PCB). The stripline is laminated by multiple inhomogeneous dielectric layers (IDL). The dielectric layers of the stripline are laminated with epoxy resin and glass bundles. The dielectric permittivity of the epoxy resin and glass bundles are different, which causes the inhomogeneity of the dielectric layers while also increasing the FEXT magnitude. The dielectric of the microstrip in printed circuit boards (PCB) fabrication usually consists of two layers: …


Promoting Distributed Energy Deployment And Diffusion For Sustainable Civil Infrastructure Using Multi-Agent Based Modeling And Quantitative Analytics, Gasser Ali Jan 2022

Promoting Distributed Energy Deployment And Diffusion For Sustainable Civil Infrastructure Using Multi-Agent Based Modeling And Quantitative Analytics, Gasser Ali

Doctoral Dissertations

"Distributed Solar Generation (DSG) using small-scale Photo-Voltaic (PV) is an evolving technology with increasingly growing market penetration due to its significant benefits to consumers and broader power systems. DSG is sustainable, provides reliability, and is cost-effective where solar energy is abundant. However, the increasingly growing adoption of DSG creates uncertainties in forecasting electric power demand and market behavior. It also causes concerns of a “utility death spiral”. To this end, the goal of this research is to critically analyze the diffusion and benefits of DSG in the electric power infrastructure as a complex System-of-Systems (SoS). Specifically, this dissertation addresses the …


Mobility Analysis And Topology Synthesis Of Compliant Mechanism Using Compliance Number And Pseudo-Rigid-Body Model (Prbm), Pratheek Bagivalu Prasanna Jan 2022

Mobility Analysis And Topology Synthesis Of Compliant Mechanism Using Compliance Number And Pseudo-Rigid-Body Model (Prbm), Pratheek Bagivalu Prasanna

Doctoral Dissertations

"Establishing and understanding the kinematic properties of a compliant mechanism has been a relatively recent endeavor and has proved to be a challenging task. A concept of compliance number was offered earlier; the development of terminologies was emphasized that aided in its determination. It also hypothesized that the compliance number (C) and stored strain energy, or mode shapes, are strongly correlated. This compliance number (C) concept is revisited, and a more lucid interpretation of its significance is provided. A fundamental understanding of the concept of deformation mode shapes in compliant mechanisms is formalized using two distinct categories: (i) segmental and …


Optimization Of Energy Storage Scheduling In Electricity Markets, Jian Liu Jan 2022

Optimization Of Energy Storage Scheduling In Electricity Markets, Jian Liu

Doctoral Dissertations

"In the existing literature, merchants' trading actions are usually assumed not to affect market prices; however, a large-scale energy storage merchant’s actions can affect market prices. This work examined two electricity merchant scenarios: one with only energy storage and the other with both energy storage and renewable power plants. We approximated market impact via a linear function of the electricity traded by the merchant. This study began by applying dynamic programming to the optimal economic dispatch policy of electricity merchants and it considered the market impact, physical characteristics of storage systems, and the uncertainty of renewable energy sources. Then, this …


Disorder Effects In Frustrated Magnets And Absorbing State Transitions, Xuecheng Ye Jan 2022

Disorder Effects In Frustrated Magnets And Absorbing State Transitions, Xuecheng Ye

Doctoral Dissertations

"Correlation, topology, and disorder can fundamentally affect the properties of interacting many-particle systems. After a short introduction which covers the basic concepts of phase transitions and scaling as well as the physics of Josephson junctions, the dissertation focuses on three separate projects.

The first project is motivated by the stripe and nematic phases observed e.g. in cuprate superconductors and iron pnictides. To understand the effects of disorder on such phases, we have investigated the behavior of the diluted J1-J2 Ising model. Spinless impurities generate a random-field disorder for the spin-density (stripe) order parameter, which destroys the stripe …


Novel Ferromagnetic Materials With Improved Mechanical Performance, Wesley Alexander Everhart Jan 2022

Novel Ferromagnetic Materials With Improved Mechanical Performance, Wesley Alexander Everhart

Doctoral Dissertations

"The ductility of intermetallics has long been a hindrance to their broad adaptation despite a significant range of properties such as magnetic, half-metallic, and shape memory behavior. The lack of a general theory for the ductility of intermetallics along with the lack of prior art that experimentally measured mechanical properties drives the need for significant investment in many of these novel magnetic materials in order to even understand, let alone correct, poor ductility.

This dissertation includes work that explored the effect of vanadium content and quenching rate on the microstructure and ductility of Fe-Co alloys. Results indicated that a martensitic …


Influences Of The Internal Residual On Combustion Instabilities In The Misfire And Partial Burn Regimes Of A Dilute Spark-Ignition Engine, Rachel Inez Stiffler Jan 2022

Influences Of The Internal Residual On Combustion Instabilities In The Misfire And Partial Burn Regimes Of A Dilute Spark-Ignition Engine, Rachel Inez Stiffler

Doctoral Dissertations

"Dilution in spark-ignition (SI) engines can improve fuel consumption and reduce emissions; however, increased levels of dilution either from excess oxidizer or exhaust gas recirculation (EGR) causes combustion to become more strained and cycle-to-cycle variations increase. At high levels of dilution incomplete combustion events (i.e. misfires and partial burns) start to occur, which cause combustion instabilities and eventually a dilute limit is reached. It is known the combustion instabilities seen are primarily due to the feed-forward mechanism present in the residual gases, but it is still unknown what about the residual is influencing the dynamics under high levels of dilution …


Development And Application Of Ensemble Machine Learning Algorithms To Enable A Priori, High-Fidelity, And Prompt Predictions And Optimizations Of Complex Materials And Systems, Taihao Han Jan 2022

Development And Application Of Ensemble Machine Learning Algorithms To Enable A Priori, High-Fidelity, And Prompt Predictions And Optimizations Of Complex Materials And Systems, Taihao Han

Doctoral Dissertations

"Complex materials consisting of multiple chemical components/phases have been widely used in different engineering applications that have strict criteria. To optimize the mixture design of complex materials, researchers invest enormous resources in cumbersome experiments. However, due to substantial variations in precursors and processing techniques, it has been challenging to develop theoretical frameworks (i.e., empirical models) that could produce reliable predictions of properties of complex materials. In recent years, scientists have harnessed the power of machine learning (ML) and “Big” data to uncover the underlying mixture design-property correlations and produce high-fidelity predictions of properties of complex materials. The ML models autonomously …


Multifunctional Behaviors Of Two-Dimensional Materials And Their Composites, Yanxiao Li Jan 2022

Multifunctional Behaviors Of Two-Dimensional Materials And Their Composites, Yanxiao Li

Doctoral Dissertations

"Two-dimensional (2D) materials, including graphene, transition metal carbides or nitrides (TMC/Ns), have rich surface chemistry, superb electrical and mechanical properties. These unique properties make them ideal for multifunctional devices. Among them, we focused on graphene and TMC/Ns (i.e., MXenes), as well as their composites. Unlike the well-known graphene, MXenes, are relatively new and typically synthesized by the selective etching of the “A” layers from the layered carbides and /or nitrides known as MAX phases, which introduce MXenes with rich terminal groups (e.g. -O-, -OH, -F).

During my Ph.D. study, firstly, the adhesive and frictional behaviors, which are related to successful …


A Machine Learning Approach For Active/Reactive Power Control Of Grid-Connected Doubly-Fed Induction Generators, Jafar Tavoosi, Ardashir Mohammadzadeh, Bahareh Pahlevanzadeh, Morad Bagherzadeh Kasmani, Shahab S. Band, Rabia Safdar, Amir H. Mosavi Jan 2022

A Machine Learning Approach For Active/Reactive Power Control Of Grid-Connected Doubly-Fed Induction Generators, Jafar Tavoosi, Ardashir Mohammadzadeh, Bahareh Pahlevanzadeh, Morad Bagherzadeh Kasmani, Shahab S. Band, Rabia Safdar, Amir H. Mosavi

Research Outputs: 2025-Present

This paper suggests a new fuzzy method for active power (AP) and reactive power (RP) control of a power grid that includes wind turbines and Doubly Fed Induction Generators (DFIGs). A Recurrent Type-II Fuzzy Neural Networks (RT2FNN) controller based on Radial Basis Function Networks (RBFN) is applied to the rotor side converter for the power control and voltage regulation of the wind turbine equipped with the DFIG. In order to train a model, the voltage profile at each bus, and the reactive power of the power grid are given to the RT2FNN as the input and output, respectively. A wind …


Analysis Of Electromagnetic Interference Problems Causedbyhigh-Speed Multiplayer Boards With Split Referenceplane, Xin Fang Jan 2022

Analysis Of Electromagnetic Interference Problems Causedbyhigh-Speed Multiplayer Boards With Split Referenceplane, Xin Fang

Masters Theses

"Digital/Analog ground partitioning has been used to isolate noisy digital and power current from sensitive analog currents in high-speed multiplayer printed circuit boards. The through-hole signal via enables convenient routing and component placement on the PCB and is used for signal interconnections when the signal traces are changing the layers. This design, however, breaks the current return path for signal traces that cross the two separated grounds, which causes undesired effects such as signal distortion and radiated emission.

Electromagnetic mechanism associated with them needs to be understood to control and suppress these undesired effects. In this paper, we have investigated …


Regional Variations And Temporal Trends Of Childhood Myopia Prevalence In Africa: A Systematic Review And Meta-Analysis, Emmnuel Kobia Acquah, Daniel Ian Flitcroft, Prince Kwaku Akowuah, Gareth Lingham, James Loughman Jan 2022

Regional Variations And Temporal Trends Of Childhood Myopia Prevalence In Africa: A Systematic Review And Meta-Analysis, Emmnuel Kobia Acquah, Daniel Ian Flitcroft, Prince Kwaku Akowuah, Gareth Lingham, James Loughman

Articles

Purpose: To provide contemporary and future estimates of childhood myopia prevalence in Africa.

Methods: A systematic online literature search was conducted for articles on childhood (≤18 years) myopia (spherical equivalent [SE] ≤ −0.50D; high myopia: SE ≤ −6.00D) in Africa. Population-or school-based cross-sectional studies published from 1 Jan 2000 to 30 May 2021 were included. Meta-analysis using Freeman–Tukey double arcsine transformation was performed to estimate the prevalence of childhood myopia and high myopia. Myopia prevalence from subgroup analyses for age groups and settings were used as baseline for generating a prediction model using linear regression.

Results: Forty-two studies from 19 …


Measuring Semantic Similarity Of Documents By Using Named Entity Recognition Methods, David Efraín Muñoz Morales Jan 2022

Measuring Semantic Similarity Of Documents By Using Named Entity Recognition Methods, David Efraín Muñoz Morales

Masters

The work presented in this thesis was born from the desire to map documents with similar semantic concepts between them. We decided to address this problem as a named entity recognition task, where we have identified key concepts in the texts we use, and we have categorized them. So, we can apply named entity recognition techniques and automatically recognize these key concepts inside other documents. However, we propose the use of a classification method based on the recognition of named entities or key phrases, where the method can detect similarities between key concepts of the texts to be analyzed, and …


Common Data Set, 2021-2022, Planning, Research, And Policy Analysis Jan 2022

Common Data Set, 2021-2022, Planning, Research, And Policy Analysis

Common Data Set (2001-present)

Common Data Set 2021-2022 for Illinois State University


First Do Not Harm: Revisiting Meriwether V. Hartop And Academic Freedom In Higher Education, Inara Scott, Elizabeth Brown, Eric Yordy Jan 2022

First Do Not Harm: Revisiting Meriwether V. Hartop And Academic Freedom In Higher Education, Inara Scott, Elizabeth Brown, Eric Yordy

American University Law Review

repeal and amend substantive statutes unilaterally, a power that can threaten bedrock commitments to our federalism and to our constitutional rights to the jury. The decisions about how and when to displace state law in favor of federal law and about how and when to grant powers to juries over judges cannot be vested in the Judicial Branch alone without the structural restraints of an Article III “case or controversy.” The paper concludes by offering some ways to fix our evidence law and to put it on firmer footing, permitting better power-sharing and dialogue between two branches of government—Congress and …


Unjustly Vilified Trips-Plus:? Intellectual Property Law In Free Trade Agreements, Marketa Trimble Jan 2022

Unjustly Vilified Trips-Plus:? Intellectual Property Law In Free Trade Agreements, Marketa Trimble

American University Law Review

Intellectual property (IP) law provisions of free trade agreements (FTAs) have attracted much criticism. Critics have argued that FTA negotiators, succumbing to the lobbying of various stakeholders, have eliminated or significantly limited many of the flexibilities that multilateral treaties had created, forced stronger IP protection onto developing countries, and fragmented international IP law. While agreeing with a great deal of the criticism expressed by others, this Article departs from the typical vilification of FTAs by identifying and analyzing the positive features of FTA IP provisions that are worth replicating and expanding in future FTAs. These positive features include provisions concerning …


First Amendment Challenges To State Vaccine Mandats: Why The U.S. Supreme Court Should Hold That The Free Exercise Clause Does Not Require Religious Exemptions, Donna M. Gitter Jan 2022

First Amendment Challenges To State Vaccine Mandats: Why The U.S. Supreme Court Should Hold That The Free Exercise Clause Does Not Require Religious Exemptions, Donna M. Gitter

American University Law Review

The U.S. Supreme Court has never issued a judicial opinion on the merits declaring that the First Amendment Free Exercise Clause permits states to mandate vaccinations without offering religious exemptions. However, in two recent cases, the Court in brief orders declined applications for emergency relief to block state vaccine mandates, and the petitioners have vowed to continue to pursue these cases.

This Article explores how the seemingly sudden onset of the coronavirus pandemic, coupled with its protracted duration, has occasioned both emergency and enduring state regulation of religious behavior in a way that exposes deep divides in our society’s views …


Considering What Faculty Value When Working With Instructional Designers And Instructional Design Teams, Jason K. Mcdonald, Salma Elsayed-Ali, Kayla Bowman, Amy Allen Rogers Jan 2022

Considering What Faculty Value When Working With Instructional Designers And Instructional Design Teams, Jason K. Mcdonald, Salma Elsayed-Ali, Kayla Bowman, Amy Allen Rogers

Faculty Publications

The purpose of this research was to study what university faculty valued when working with instructional designers and instructional design teams to develop educational simulations. We did this through a case study of three faculty, where we analyzed what they discussed among themselves or communicated to other team members about what mattered to them about their team relationships or the design processes they employed. We structured our case report around three thematic issues that expressed how our participants depicted good relationships and processes. Our report concludes with a discussion of how instructional designers could use our findings in their practice.


Hinterlands To Cities: The Archaeology Of Northwest Mexico And Its Vecinos, Matthew C. Pailes, Michael T. Searcy Jan 2022

Hinterlands To Cities: The Archaeology Of Northwest Mexico And Its Vecinos, Matthew C. Pailes, Michael T. Searcy

Faculty Publications

Tis approachable book is a comprehensive synthesis of Northwest Mexico from the US border to the Mesoamerican frontier. Filling a vital gap in the regional literature, it serves as an essential reference not only for those interested in the specific history of this area of Mexico but western North America writ large. A period-by-period review of approximately14,000 years reveals the dynamic connections that knitted together societies inhabiting the Sea of Cortez coast, the Sonoran and Chihuahuan deserts, and the Sierra Madre Occidental. Networks of interaction spanned these diverse ecological, topographical, and cultural terrains in the millennia following the demise of …


Fremont Smoke Mixtures: Botanical Analyses Of Pipes From Wolf Village, Goshen, Utah, Michael T. Searcy, Hannah Stefffensen, Scott Ure Jan 2022

Fremont Smoke Mixtures: Botanical Analyses Of Pipes From Wolf Village, Goshen, Utah, Michael T. Searcy, Hannah Stefffensen, Scott Ure

Faculty Publications

Over several field seasons, ceramic and stone pipes were recovered from the Fremont site of Wolf Village (AD 1000-1100). Nine of the more complete pipes included residue and burned dottle that were analyzed for macrobotanical and microbotanical remains. Three were subjected to FTIR. These analyses represent the first Fremont pipes ever analyzed for botanical remains, and the results reported in this paper provide conclusions regarding possible smoke mixtures used by the Fremont. Contents of the pipes included remains of tobacco, plants from the Amaranthaceae family, maize fragments, grasses, and various fuel woods.


Book Review Of Early Farming And Warfare In Northwest Mexico (Robert Jarratt Hard And John R. Roney), Michael T. Searcy Jan 2022

Book Review Of Early Farming And Warfare In Northwest Mexico (Robert Jarratt Hard And John R. Roney), Michael T. Searcy

Faculty Publications

Like many archaeologists working in northern Mexico and the US Southwest, I have eagerly anticipated this volume and its reporting of the Early Agricultural (Middle-Late Archaic) occupation in northwestern Chihuahua. Primarily, it documents the research conducted by the coauthors over several years at sites known as cerros de trincheras, or terraced hills. These were massive construction projects resulting in habitational terraces built by early maize farmers who began to settle in the Casas Grandes River Valley and surrounding areas more than 3,000 years ago.


Redating Paquimé And The Convento Site Sixty Years After The Joint Casas Grandes Expedition In Northwestern Mexico, Samuel Jensen, Michael T. Searcy, Meradeth Snow Jan 2022

Redating Paquimé And The Convento Site Sixty Years After The Joint Casas Grandes Expedition In Northwestern Mexico, Samuel Jensen, Michael T. Searcy, Meradeth Snow

Faculty Publications

Debates continue regarding the rise of the Late Prehistoric (post-AD 1200) city of Paquimé in northwestern Chihuahua, Mexico. Unfortunately, the established chronology of the site was flawed due to incorrect interpretations of dendrochronological samples that lacked cutting dates (i.e., outer rings). While Dean and Ravesloot (1993) were able to determine this mistake through a reanalysis of the original chronological sequence, no attempts have been made to revise the chronology using new dates. This poster reports the results of new radiocarbon dates analyzed from samples of human remains found at Paquimé during the Joint Casas Grandes Expedition from 1958 to 1961. …


Neurology Resident Eeg Training In Europe, Fábio A Nascimento, Jay R Gavvala, Hatice Tankisi, Sándor Beniczky Jan 2022

Neurology Resident Eeg Training In Europe, Fábio A Nascimento, Jay R Gavvala, Hatice Tankisi, Sándor Beniczky

Faculty, Staff and Student Publications

OBJECTIVE: To detail current European EEG education practices and compare European and U.S. EEG teaching systems.

METHODS: A 19-question online survey focused on EEG clinical practices and residency training was emailed to all 47 European Academy of Neurology Societies.

RESULTS: Thirty-two (68 %) out of the 47 Societies completed the survey. In half of countries, general neurologists are either among the providers or the only providers who typically read EEGs. The number of weeks devoted to EEG learning required to graduate ranged from none to 26, and it was expected to be continuous in one country. In most countries (n …


A T-Cell Engaging Bispecific Antibody With A Tumor-Selective Bivalent Folate Receptor Alpha Binding Arm For The Treatment Of Ovarian Cancer, Brian C Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A Boudreau, Ben Buelow, Karen Chang, Laura M Davison, Suhasini Iyer, Vidyut Kalwit, Kristin Lewis Wilson, Harbani K Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S Ugamraj, Rodolfovan D Yabut, Roland Buelow, Jocelyn Chapman, Nathan D Trinklein, Katherine E Harris Jan 2022

A T-Cell Engaging Bispecific Antibody With A Tumor-Selective Bivalent Folate Receptor Alpha Binding Arm For The Treatment Of Ovarian Cancer, Brian C Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A Boudreau, Ben Buelow, Karen Chang, Laura M Davison, Suhasini Iyer, Vidyut Kalwit, Kristin Lewis Wilson, Harbani K Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S Ugamraj, Rodolfovan D Yabut, Roland Buelow, Jocelyn Chapman, Nathan D Trinklein, Katherine E Harris

Faculty, Staff and Student Publications

The use of T-cell engagers (TCEs) to treat solid tumors is challenging, and several have been limited by narrow therapeutic windows due to substantial on-target, off-tumor toxicities due to the expression of low levels of target antigens on healthy tissues. Here, we describe TNB-928B, a fully human TCE that has a bivalent binding arm for folate receptor alpha (FRα) to selectively target FRα overexpressing tumor cells while avoiding the lysis of cells with low levels of FRα expression. The bivalent design of the FRα binding arm confers tumor selectivity due to low-affinity but high-avidity binding to high FRα antigen density …


A Hybrid Unsupervised And Supervised Learning Approach For Postictal Generalized Eeg Suppression Detection, Xiaojin Li, Yan Huang, Samden D Lhatoo, Shiqiang Tao, Laura Vilella Bertran, Guo-Qiang Zhang, Licong Cui Jan 2022

A Hybrid Unsupervised And Supervised Learning Approach For Postictal Generalized Eeg Suppression Detection, Xiaojin Li, Yan Huang, Samden D Lhatoo, Shiqiang Tao, Laura Vilella Bertran, Guo-Qiang Zhang, Licong Cui

Faculty, Staff and Student Publications

Sudden unexpected death of epilepsy (SUDEP) is a catastrophic and fatal complication of epilepsy and is the primary cause of mortality in those who have uncontrolled seizures. While several multifactorial processes have been implicated including cardiac, respiratory, autonomic dysfunction leading to arrhythmia, hypoxia, and cessation of cerebral and brainstem function, the mechanisms underlying SUDEP are not completely understood. Postictal generalized electroencephalogram (EEG) suppression (PGES) is a potential risk marker for SUDEP, as studies have shown that prolonged PGES was significantly associated with a higher risk of SUDEP. Automated PGES detection techniques have been developed to efficiently obtain PGES durations for …


More Than Just Statics: Static And Temporal Dynamic Changes In Intrinsic Brain Activity In Unilateral Temporal Lobe Epilepsy, Chengru Song, Xiaonan Zhang, Shaoqiang Han, Keran Ma, Kefan Wang, Xinyue Mao, Yajun Lian, Xianchang Zhang, Jinxia Zhu, Yong Zhang, Jingliang Cheng Jan 2022

More Than Just Statics: Static And Temporal Dynamic Changes In Intrinsic Brain Activity In Unilateral Temporal Lobe Epilepsy, Chengru Song, Xiaonan Zhang, Shaoqiang Han, Keran Ma, Kefan Wang, Xinyue Mao, Yajun Lian, Xianchang Zhang, Jinxia Zhu, Yong Zhang, Jingliang Cheng

Faculty, Staff and Student Publications

BACKGROUND: Temporal lobe epilepsy (TLE) is the most prevalent refractory focal epilepsy and is more likely accompanied by cognitive impairment. The fully understanding of the neuronal activity underlying TLE is of great significance.

OBJECTIVE: This study aimed to comprehensively explore the potential brain activity abnormalities affected by TLE and detect whether the changes were associated with cognition.

METHODS: Six static intrinsic brain activity (IBA) indicators [amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), degree centrality (DC), global signal correlation (GSCorr), and voxel-mirrored homotopic connectivity (VMHC)] and their corresponding dynamic indicators, such as dynamic ALFF (dALFF), dynamic fALFF …