Digital Commons Network^™

Agenda Setting And Europe's Common Immigration Policy, Jamie P. Surface

Dissertations and Theses

For over a decade the European Union has been immersed in an immigration crisis. As the desired destination for millions of people fleeing unrest in the Middle East and war in Ukraine, the EU has developed its own social, political, and humanitarian crisis. Lacking policy commonality across its member states on how to accept and manage the mass waves of migrants, the EU continues to struggle with implementing a common immigration policy. This research examines EU immigration issues, policies, and the failures of successful collaboration stymying the implementation of a standard immigration policy. Using the agenda setting model of John …

Palliative Care Reduces Emergency Room Visits And Total Hospital Days Among Patients With Metastatic Hpb And Gi Cancers, Angelle A. Billiot, Denise M. Danos, Jenny Stevens, Katie M. Vance, Mary C. Raven, John M. Lyons

School of Public Health Faculty Publications

Palliative care services (PCS) have improved quality of life for patients across various cancer subtypes. Minimal data exists regarding PCSfor metastatic hepatopancreaticobiliary (HPB) and gastrointestinal (GI) cancers. We assessed the impact of PCS on emergency department visits, hospital admissions, and survival among these patients. Patients with metastatic HPB and GI cancer referred to outpatient PCS between 2014 and 2018 at a single institution were included. We compared the demographics, outcomes, and end-of-life indicators between those who did and did not receive PCS. The study included 183 patients, with 118 (64.5%) having received PCS. There were no significant differences in age, …

Ucc Minutes 12-6-22, Angela Brock

UCC Agendas/Minutes

No abstract provided.

In Silico Identification Of A Β2-Adrenoceptor Allosteric Site That Selectively Augments Canonical Β2ar-Gs Signaling And Function, Sushrut D Shah, Christoffer Lind, Francesco De Pascali, Raymond B Penn, Alexander D Mackerell, Deepak A Deshpande

Department of Biochemistry and Molecular Biology Faculty Papers

Activation of β2-adrenoceptors (β2ARs) causes airway smooth muscle (ASM) relaxation and bronchodilation, and β2AR agonists (β-agonists) are front-line treatments for asthma and other obstructive lung diseases. However, the therapeutic efficacy of β-agonists is limited by agonist-induced β2AR desensitization and noncanonical β2AR signaling involving β-arrestin that is shown to promote asthma pathophysiology. Accordingly, we undertook the identification of an allosteric site on β2AR that could modulate the activity of β-agonists to overcome these limitations. We employed the site identification by ligand competitive saturation (SILCS) computational method to comprehensively map the entire 3D structure of in silico-generated β2AR intermediate conformations and identified …

Modulation Of Sirtuins During Monolayer Chondrocyte Culture Influences Cartilage Regeneration Upon Transfer To A 3d Culture Environment, Hannah K Heywood, Stephen D Thorpe, Renos M Jeropoulos, Paul W Caton, David A Lee

Faculty, Staff and Student Publications

This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis. By inhibiting pro-inflammatory pathways responsible for cartilage degradation and promoting the expression of key matrix components, sirtuins have the potential to drive a favourable balance between anabolic and catabolic processes critical to regenerative medicine. When subjected to osmolarity and glucose concentrations representative of the in vivo niche, freshly isolated bovine chondrocytes exhibited increases in SIRT1 but not SIRT3 gene expression. Replicating methods adopted for the in vitro monolayer expansion of chondrocytes for cartilage regenerative therapies, we …

A Hug For Humanity: Metamodernism And Masculinity On Television In Ted Lasso, Kennedy Lesley Koford

Theses and Dissertations

The Apple TV+ sports comedy Ted Lasso has been a hit among fans, who flock to the show and its positive messages. The show offers a refreshing tone, one that promotes positivity and optimism even when faced with the reality of a cynical world. By using the analytical perspective of metamodernism to understand its popularity, scholars and fans alike can gain a deeper understanding of core message of the show, which mimics the oscillation between the cynical and the sincere. Fundamental scholars in the emerging study of metamodernism, such as Robin Van Den Akker, Timotheus Vermeulen, and Alison Gibbons will …

The Integrative Conjugative Element Icespym92 Contributes To Pathogenicity Of Emergent Antimicrobial-Resistant Emm92 Group A Streptococcus, Ji-Sun Lee, Michael W Lero, Jose Mercado-Matos, Sha Zhu, Minjeong Jo, Claire E Tocheny, Jennifer S Morgan, Leslie M Shaw

Faculty, Staff and Student Publications

Despite the strong association of the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway with tumor initiation, recurrence, and metastasis, the mechanism by which this pathway regulates cancer progression is not well understood. Here, we report that IIS supports breast cancer stem cell (CSC) self-renewal in an IRS2-phosphatidylinositol 3-kinase (PI3K)-dependent manner that involves the activation and stabilization of MYC. IRS2-PI3K signaling enhances MYC expression through the inhibition of GSK3β activity and suppression of MYC phosphorylation on threonine 58, thus reducing proteasome-mediated degradation of MYC and sustaining active pS62-MYC function. A stable T58A-Myc mutant rescues CSC function in Irs2−/− cells, supporting …

Procedural Outcomes After Percutaneous Coronary Interventions In Focal And Diffuse Coronary Artery Disease, Takuya Mizukami, Jeroen Sonck, Koshiro Sakai, Brian Ko, Michael Maeng, Hiromasa Otake, Bon-Kwon Koo, Sakura Nagumo, Bjarne L Nørgaard, Jonathon Leipsic, Toshiro Shinke, Daniel Munhoz, Niya Mileva, Marta Belmonte, Hirofumi Ohashi, Emanuele Barbato, Nils P Johnson, Bernard De Bruyne, Carlos Collet

Faculty, Staff and Student Publications

Background

Coronary artery disease (CAD) patterns play an essential role in the decision‐making process about revascularization. The pullback pressure gradient (PPG) quantifies CAD patterns as either focal or diffuse based on fractional flow reserve (FFR) pullbacks. The objective of this study was to evaluate the impact of CAD patterns on acute percutaneous coronary intervention (PCI) results considered surrogates of clinical outcomes.

Methods and Results

This was a prospective, multicenter study of patients with hemodynamically significant CAD undergoing PCI. Motorized FFR pullbacks and optical coherence tomography (OCT) were performed before and after PCI. Post‐PCI FFR >0.90 was considered an optimal result. …

Plasma Growth Hormone Is A Potential Biomarker Of Response To Atezolizumab And Bevacizumab In Advanced Hepatocellular Carcinoma Patients, Yehia I Mohamed, Dan G Duda, Muhammad O Awiwi, Sunyoung S Lee, Lina Altameemi, Lianchun Xiao, Jeffrey S Morris, Robert A Wolff, Khaled M Elsayes, Rikita I Hatia, Aliya Qayyum, Shadi M Chamseddine, Asif Rashid, James C Yao, Armeen Mahvash, Manal M Hassan, Hesham M Amin, Ahmed Omar Kaseb

Faculty, Staff and Student Publications

INTRODUCTION: Hepatocellular carcinoma (HCC) has limited systemic therapy options when discovered at an advanced stage. Thus, there is a need for accessible and minimally invasive biomarkers of response to guide the selection of patients for treatment. This study investigated the biomarker value of plasma growth hormone (GH) level as a potential biomarker to predict outcome in unresectable HCC patients treated with current standard therapy, atezolizumab plus bevacizumab (Atezo/Bev).

MATERIALS AND METHODS: Study included unresectable HCC patients scheduled to receive Atezo/Bev. Patients were followed to determine progression-free survival (PFS) and overall survival (OS). Plasma GH levels were measured by ELISA and …

Doesn't Your Work Just Re-Center Whiteness? The Fallen Impossibilities Of White Allyship, Pauli Badenhorst, James Jupp, Jenna Min Shim, Timothy J. Lensmire, Zachary A. Casey, Samuel J. Tanner, Veronica Watson, Erin Miller

Teaching and Learning Faculty Publications

Our purpose is to engage performative dialogue incorporative of currere on a central question in critical White studies (CWS). After precautionary notes and positionalities, we frame our dialogue within second-wave CWS. As its main section, six CWS scholars respond to the central question: Doesn’t research on White identities re-center whiteness? Analyzing the scholars’ responses, the performative dialogue is followed by an analytical discussion of CWS’ epistemological, ontological, and axiological convolutions. Via these convolutions, we recognize the impossibilities of facile “White allyship” within antiracist scholarship, curriculum and pedagogy, and related social movements. Instead of White allyship, we propose situated, relational, and …

Popdc1 Scaffolds A Complex Of Adenylyl Cyclase 9 And The Potassium Channel Trek-1 In Heart, Tanya A Baldwin, Yong Li, Autumn N Marsden, Susanne Rinné, Anibal Garza-Carbajal, Roland F R Schindler, Musi Zhang, Mia A Garcia, Venugopal Reddy Venna, Niels Decher, Thomas Brand, Carmen W Dessauer

Faculty, Staff and Student Publications

The establishment of macromolecular complexes by scaffolding proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for cardiac functions. We identify a novel AC scaffold, the Popeye domain-containing (POPDC) protein. The POPDC family of proteins is important for cardiac pacemaking and conduction, due in part to their cAMP-dependent binding and regulation of TREK-1 potassium channels. We show that TREK-1 binds the AC9:POPDC1 complex and copurifies in a POPDC1-dependent manner with AC9 activity in heart. Although the AC9:POPDC1 interaction is cAMP-independent, TREK-1 association with AC9 and POPDC1 is reduced upon …

Identification Of Acenkps, A Committed Common Progenitor Population Of The Ilc1 And Nk Cell Continuum, Noe Rodriguez-Rodriguez, Paula A Clark, Mayuri Gogoi, Ana C F Ferreira, Bernhard Kerscher, Alastair Crisp, Helen E Jolin, Jane E Murphy, Meera Sivasubramaniam, Luisa Pedro, Jennifer A Walker, Morgan W D Heycock, Jacqueline D Shields, Jillian L Barlow, Andrew N J Mckenzie

Faculty, Staff and Student Publications

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage-Id2+IL-7Rα+CD25-α4β7-NKG2A/C/E+Bcl11b-. In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2-/-Il2rg-/- hosts, aceNKPs give rise to a spectrum of mature ILC1/NK cells …

Possibilities For Inertial Electrostatic Confinement Fusion, Jeffrey Edward Black

Dissertations and Theses

While most of the fusion energy research is focused on magnetic confinement, there have been several alternative confinement methods aimed at the development of smaller and less expensive reactors. A number of these devices utilize a spherically convergent beam of recirculating ions, a technique known as inertial electrostatic confinement (IEC). This study looks at several aspects of IEC devices, including measurements of the fusion rate of an IEC device with a wire mesh electrode cathode, and a solid titanium cathode. In addition, several computational studies were performed to explore the possibilities for IEC fusion. These include development of a 1D-1P …

High Resolution Modeling Of Vegetation Reveals Large Summertime Biogenic Co2 Fluxes In New York City, Dandan Wei, Andrew Reinmann, Luke D. Schiferl, Roisin Commane

Advanced Science Research Center

Cities are beginning to monitor atmospheric carbon dioxide (CO₂) to assess the efficacy of their climate policies. However, changes in anthropogenic CO₂ emissions must be separated from biospheric CO₂ fluxes which have a large seasonal cycle. Urban vegetation (e.g. lawns, trees along street and in parks, etc) in developed land covers is often omitted in regional biogenic CO₂ flux models. We set up a biosphere model to estimate the regional biogenic CO₂ fluxes in New York City (NYC) and assess the importance of vegetation within developed land covers. The model incorporates a high-resolution (30 …

Unfavorable Social Determinants Of Health Are Associated With Higher Burden Of Financial Toxicity Among Patients With Atherosclerotic Cardiovascular Disease In The Us: Findings From The National Health Interview Survey, Javier Valero-Elizondo, Zulqarnain Javed, Rohan Khera, Mauricio E Tano, Ramzi Dudum, Isaac Acquah, Adnan A Hyder, Julia Andrieni, Garima Sharma, Michael J Blaha, Salim S Virani, Ron Blankstein, Miguel Cainzos-Achirica, Khurram Nasir

Faculty, Staff and Students Publications

• D: PMC9727868

The Double Silence: Reflections On Music And Musicians, Antoni Pizà

Publications and Research

A translation of EL DOBLE SILENCI, published in Catalan in 2003. The book is a compilation of essays originally published in Diario de Mallorca (2000-2003).

Tele-Medicine Based And Self-Administered Interactive Exercise Program (Tele-Exergame) To Improve Cognition In Older Adults With Mild Cognitive Impairment Or Dementia: A Feasibility, Acceptability, And Proof-Of-Concept Study, Catherine Park, Ram Kinker Mishra, Michele K York, Ana Enriquez, Abigail Lindsay, Gregory Barchard, Ashkan Vaziri, Bijan Najafi

Center on Aging Staff Publications

Improved life expectancy is increasing the number of older adults who suffer from motor-cognitive decline. Unfortunately, conventional balance exercise programs are not tailored to patients with cognitive impairments, and exercise adherence is often poor due to unsupervised settings. This study describes the acceptability and feasibility of a sensor-based in-home interactive exercise system, called tele-Exergame, used by older adults with mild cognitive impairment (MCI) or dementia. Our tele-Exergame is specifically designed to improve balance and cognition during distractive conditioning while a telemedicine interface remotely supervises the exercise, and its exercises are gamified balance tasks with explicit augmented visual feedback. Fourteen adults …

Mechanisms Of Irf2bpl-Related Disorders And Identification Of A Potential Therapeutic Strategy, Shrestha Sinha Ray, Debdeep Dutta, Cassandra Dennys, Samantha Powers, Florence Roussel, Pawel Lisowski, Petar Glažar, Xiaojin Zhang, Pipasha Biswas, Joseph R Caporale, Nikolaus Rajewsky, Marc Bickle, Nicolas Wein, Hugo J Bellen, Shibi Likhite, Paul C Marcogliese, Kathrin C Meyer

Faculty, Staff and Students Publications

The recently discovered neurological disorder NEDAMSS is caused by heterozygous truncations in the transcriptional regulator IRF2BPL. Here, we reprogram patient skin fibroblasts to astrocytes and neurons to study mechanisms of this newly described disease. While full-length IRF2BPL primarily localizes to the nucleus, truncated patient variants sequester the wild-type protein to the cytoplasm and cause aggregation. Moreover, patient astrocytes fail to support neuronal survival in coculture and exhibit aberrant mitochondria and respiratory dysfunction. Treatment with the small molecule copper ATSM (CuATSM) rescues neuronal survival and restores mitochondrial function. Importantly, the in vitro findings are recapitulated in vivo, where co-expression of full-length …

The Impact And Utilization Of Reading Interventionists, Kristi Allen, Rachelle Loven

i.e.: inquiry in education

The purpose of this qualitative, semi-structured interview study was to explore the role of a reading interventionist within an elementary school setting to help bring increased clarity to the responsibilities of a reading interventionist. Research questions focused on the role and impact reading interventionists when working with developing readers at the elementary level. Twelve reading interventionists from around the United States were chosen to participate in the interview. Multiple data sources were used including audio recordings transcribed, follow-up questions, and memos. Elementary schools have implemented a Response to Intervention model where reading interventionists focused on Tier 2 and Tier 3 …

The Impact Of Teacher Research On Classroom Practice And Teacher Autonomy, Connie Dilucchio, Heather Leaman

i.e.: inquiry in education

Abstract:
Faculty instructors of a master’s level teacher research course share findings from a study on the impact of teacher researcher on classroom practice and teacher autonomy. Authors describe the M.Ed. program and research capstone course where graduate students (practicing teachers) complete a semester-long research project. They share their qualitative inquiry examining the impact of teacher research on participants who completed teacher research 2010-2018. Findings derived from surveys and interviews suggest that teachers (a) adapt their instructional practices and their thinking about learners’ needs and (b) develop confidence and a greater sense of autonomy following a semester-long research experience. Authors …

Investigating The Effect Of Differentiated Instruction On Academic Achievement And Self-Directed Learning Readiness In An Online Teaching Profession Course, Fatma Özüdoğru Dr.

i.e.: inquiry in education

This research investigated the effect of differentiated instruction on Turkish preservice teachers’ academic achievement and self-directed learning readiness in an online teaching profession course. The study utilized a pretest-posttest control group design. Data were collected through an achievement test and a self-directed learning readiness scale. The independent samples t-test, paired samples t-test and analysis of covariance were used to analyze the data. The findings revealed that online differentiated instruction had a significant impact on the academic achievement of preservice teachers while it did not create a significant difference in terms of self-directed learning readiness. As a reult, it is seen …

Standing In The Gap, Post Covid-19, Carol Burg

i.e.: inquiry in education

Editorial for Fall 2022 issue.

The Art Of The Essential, Julia Conover

Valparaiso Fiction Review

No abstract provided.

Boulder And Back, Tom Gartner

Valparaiso Fiction Review

No abstract provided.

Prefatory Notes

Valparaiso Fiction Review

No abstract provided.

Capstone: Interprofessional Collaboration, Caleb Dobbs

Social Work Masters Capstone Projects

Interprofessional collaboration is vital in the social work profession. Working with an interprofessional team consisting of various professions and backgrounds is both challenging and rewarding when done correctly. There are numerous models and theories out there for best practices for interprofessional collaboration. This paper evaluates different facets of interprofessional teamwork as a client case study rooted in the nine competencies set forth by the CSWE at the micro, mezzo, and macro level. Topics such as Michelle P. Waiver program, Model for Interdisciplinary Collaboration, ethical dilemmas and violation, how to be culturally responsive, how to handle client termination, and using self-care …

Lanthorn, Vol. 57, No. 16, December 5, 2022, Grand Valley State University

Volume 57, August 1, 2022 - April 10, 2023

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Shakespeare, Sign Language, And The Seraglio, Ashleigh Sabin

Fall Student Research Symposium 2022

The research in this project aims to give context for a reference to a "mute" in Shakespeare's play Twelfth Night (1603), more broadly examine early modern British ideas about deafness and the Ottoman Empire, and examine the non-verbal community in the palace of the seventeenth-century Ottoman Empire (the Seraglio). In this presentation, I argue that early modern British understanding of deaf and non-verbal communities was intrinsically tied to the Ottoman Empire and that this association created both advantages and disadvantages for deaf and non-verbal people in England, as well as continental Europe.

Indigenous Citizens And Black Republicans: Continuities And Evolutions Of Subalterns’ Political Visions And Repertoires In Post-Independence Colombia And Mexico, James Sanders

History Faculty Publications

This essay focuses on how Indigenous peoples in Colombia and Mexico sought to create a distinct politics, in which they could protect their colonial identities and local customs, within the new independent and republican nation-states of the Americas. Indigenous communities succeed in combining universal republican citizenship and particular colonial identities, maintaining more of a connection with the past, but nevertheless creating innovative solutions to adapt to the republican present. In contrast, popular African-Colombian actors eagerly embraced the possibilities of citizenship in new republican nation states, seeking to abandon a colonial identity associated with slavery. Both Afro-Colombians and Indígenas adapted traditional …

You Need This: Global Fast Fashion, Environment, And Consumption Culture, Alexandra Lamm

Student Work

In looking at how global production of clothing has increased and shifted, we see the impacts in places like workers rights, environmental issues and cultural consumption. Although vastly different, through examination we will see how all are intrinsically linked. We have reached a truly global economy, and even when threatened with negative consequences of mass consumption in our daily lives, the road to actual change in the fashion industry becomes harder in time due to our dependency on the industry as a whole.