Digital Commons Network^™

An Elf4 Hypomorphic Variant Results In Nk Cell Deficiency, Sandra Andrea Salinas, Emily M Mace, Matilde I Conte, Chun Shik Park, Yu Li, Joshua I Rosario-Sepulveda, Sanjana Mahapatra, Emily K Moore, Evelyn R Hernandez, Ivan K Chinn, Abigail E Reed, Barclay J Lee, Alexander Frumovitz, Richard A Gibbs, Jennifer E Posey, Lisa R Forbes Satter, Akaluck Thatayatikom, Eric J Allenspach, Theodore G Wensel, James R Lupski, H Daniel Lacorazza, Jordan S Orange

Faculty, Staff and Students Publications

NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD experience higher susceptibility to chronic, recurrent, and fatal viral infections. An individual with recurrent viral infections and mild hypogammaglobulinemia was identified to have an X-linked damaging variant in the transcription factor gene ELF4. The variant does not decrease expression but disrupts ELF4 protein interactions and DNA binding, reducing transcriptional activation of target genes and selectively impairing ELF4 function. Corroborating previous murine models …

Lpa Disruption With Aav-Crispr Potently Lowers Plasma Apo(A) In Transgenic Mouse Model: A Proof-Of-Concept Study, Alexandria M Doerfler, So Hyun Park, Julia M Assini, Amer Youssef, Lavanya Saxena, Adam B Yaseen, Marco De Giorgi, Marcel Chuecos, Ayrea E Hurley, Ang Li, Santica M Marcovina, Gang Bao, Michael B Boffa, Marlys L Koschinsky, William R Lagor

Faculty, Staff and Students Publications

Lipoprotein(a) (Lp(a)) represents a unique subclass of circulating lipoprotein particles and consists of an apolipoprotein(a) (apo(a)) molecule covalently bound to apolipoprotein B-100. The metabolism of Lp(a) particles is distinct from that of low-density lipoprotein (LDL) cholesterol, and currently approved lipid-lowering drugs do not provide substantial reductions in Lp(a), a causal risk factor for cardiovascular disease. Somatic genome editing has the potential to be a one-time therapy for individuals with extremely high Lp(a). We generated an

Coaches Supporting Teachers Reluctant To Implement Intervention Instruction: The Role Of Reflection, Elizabeth Cutrer, Erica E. Miller

Faculty Publications

No abstract provided.

Impacts Of The Poultry Industry In Mississippi, Sara Watts

Master's Theses

This thesis examines the impacts of the poultry industry in seven counties in the Piney Woods region of South Mississippi: Wayne, Jones, Forrest, Lamar, Jefferson Davis, Marion, and Pike. Current research indicates that the poultry industry has a significant impact on the cultures and economies of rural towns throughout the United States. There is no current research that examines the effects of the poultry industry on residents of the Piney Woods. This thesis addresses that gap in the research and contributes to current understanding of how the industry molds and impacts the lives of those intimately associated with it.

I …

Lechuguilla Cave – Discoveries In A Hidden Splendor, Victor J. Polyak

International Journal of Speleology

No abstract provided.

John O'Malley As A Guide For Eloquentia Perfecta, Community-Engaged Work, And Graduate Education, Allen Brizee, Stephanie Hurter Brizee, Colten Biro, Meha Gupta

Jesuit Higher Education: A Journal

John O’Malley, S.J., was primarily a Jesuit and Catholic historian. But to scholars in writing studies, his work is illuminative due to his rhetorical analysis of church documents and his discussion of eloquentia perfecta when examining Jesuit education. More recently, in works like “’Not for Ourselves Alone,” he stresses the importance of Jesuit education focusing on the betterment of others inside and outside of the academy. During an interview conducted four months before his death, O’Malley restated the necessity of Jesuit education including writing and vita activa, that is, active civic life. In this article, we pay tribute to …

John W. O'Malley: Scholar Of Eloquence And Eloquent Scholar, Cinthia Gannett, John Brereton, Allen Brizee

Jesuit Higher Education: A Journal

ABSTRACT

As the essays in this volume attest, John O’Malley, S.J., has been an intellectual force in the proud tradition of the erudite, generative, multi-lingual polymaths of the early Society. Reading the recent memoir on his rich scholarly life over several decades, The Education of a Historian (2021)i, viewing the wonderful Georgetown Interview (2021), and having had the chance to interview him in Baltimore on May 26, 2022,ii we are struck by his relentless curiosities across multiple fields of historical inquiry and his willingness to follow his questions over decades as they take on new forms and incarnations, both alone …

The Contributions Of John O’Malley, Sj, To The Ongoing Reception Of Vatican Ii, Massimo Faggioli

Jesuit Higher Education: A Journal

The article analyzes the major contributions of John O’Malley, SJ, to the reception of the Second Vatican Council, especially thanks to his book What Happened at Vatican II (2008) but also in the context of his other books on the council of Trent (2013) and on Vatican I (2018). O’Malley’s contributions are particularly important in the context of what can be called a crisis of reception of Vatican II and of an ecclesial disruption. But it is relevant for Catholic theology and Catholic higher education because the current ecclesial and theological crisis has, among its causes, also a lack of …

The First Jesuits And The First Jesuit Universities, Paul Grendler

Jesuit Higher Education: A Journal

John W. O’Malley S. J. in The First Jesuits described well the basic principles of the Jesuit educational ministry that shapeed Jesuit schools and universities. He did not discuss what constituted a Jesuit university because that was not the purpose of the book. After assessing the major contributions that O’Malley made to define the principles of Jesuit education, this article will pick up where O’Malley left off by describing the first Jesuit universities. There was not a single model of a Jesuit university. Instead, the Jesuits taught in four kinds of universities: the all-Jesuit university, the civic-Jesuit collegiate university, the …

John O’Malley And Jesuit Education: A Journey Into Humanism, Cristiano Casalini, Alessandro Corsi

Jesuit Higher Education: A Journal

This article reflects upon the impact of the work of John W. O’Malley, S.J. (1927–2022), on the field of the history of Jesuit education. In The First Jesuits (1993), O’Malley provided an innovative approach to the subject that refuted some long-standing preconceptions about the way Jesuit schools and universities had originally developed. The approach that he took to to the topic throughout the 1990s and 2000s allowed him to identify two intertwined educational traditions at the heart of the Jesuit pedagogical model: the humanistic tradition of the Renaissance period, based on the Isocratic concept of pietas, and the scholastic …

“And There The Pagans Reigned”: Epideictic, Shared Appreciation, Social History, Stephen Schloesser Sj

Jesuit Higher Education: A Journal

John W. O’Malley, S.J. highlighted the “pagan” origins of the texts recovered from classical antiquity by Renaissance humanists. Although these ancient writers had no relationship to either the Jewish or Christian religions of the Book, their writings were nevertheless valued for offering wisdom and moral insights. Thanks to the epideictic rhetorical genre, shared appreciation across boundaries was emphasized. However, O’Malley also avoided rigidity or literalism in applying principles of the past to contemporary circumstances. Ancient documents are one kind of source; the “social history” in actual practice and application of those documents is another kind of source. This essay surveys …

John O'Malley And "How We Got To Be Who We Are", Mary Kate Holman

Jesuit Higher Education: A Journal

No abstract provided.

Real Actors, Connor Fisher

The Woodward Review: A Creative and Critical Journal

No abstract provided.

In The Wild // On Charles Darwin's Theory Of Evolution, Nnandi Samuel

The Woodward Review: A Creative and Critical Journal

No abstract provided.

And // In The Criss, Mark Goodwin

The Woodward Review: A Creative and Critical Journal

No abstract provided.

What Burning The Air Means For A Man Waiting Too Long All That Remains Of Him Is Dust And Shadow, Elias Udo-Ochi

The Woodward Review: A Creative and Critical Journal

No abstract provided.

(From) Dreamlife Of Honey, Marcus Slease

The Woodward Review: A Creative and Critical Journal

No abstract provided.

El Metodo, Juanita Rey

The Woodward Review: A Creative and Critical Journal

No abstract provided.

Full Issue: The Woodward Review 2.1 Winter 2022, The Woodward Review Editors

The Woodward Review: A Creative and Critical Journal

No abstract provided.

Accessibility Of University Course Syllabi, Steven M. Baule, Sara A. Fister

Essays in Education

Over the last twenty years, governments and a range of disability rights organizations have advocated for increased accessibility to educational materials and school documents for people with disabilities. Recently, several studies have shown that accessibility is still lagging among educational institutions and other government agencies. The purpose of this study was to analyze extant higher education syllabi to determine the level of compliance with the current Web Content Accessibility Guidelines (WCAG 2.0). The study reviewed the current accessibility requirements for schools under WCAG 2.0 and Section 508 of the Rehabilitation Act as amended in 2018. It then provides a review …

Stem And High School Students With Disabilities: A Qualitative Review Of The Research Literature, Scott Yamamoto Ph.D., Charlotte Y. Alverson Ph.D., Laura Mccoid-Goudy M.A.T., Hannah Castle B.A., Jacquelyn Burr M.Ed.

Journal of Science Education for Students with Disabilities

We conducted a qualitative review of the research literature on STEM (science, technology, engineering, mathematics) related to high school students with disabilities (SWD). We selected and analyzed 53 articles to answer two questions: (1) How are high-school SWD prepared for careers in STEM? (2) How are educators prepared to support high-school SWD for opportunities in STEM? In answering the first question, four qualitative themes emerged: (a) barriers to STEM, (b) increasing STEM opportunities, (c) STEM readiness in college and career, and (d) STEM identity. In answering the second question, three qualitative themes emerged: (a) individualizing learning and supports for SWD, …

A Distinctly Dordt Vision, Sarah Moss

The Voice

No abstract provided.

Academic Enrichment Center Gets Major Enhancements, Sarah Moss

The Voice

No abstract provided.

Worldwide Distribution Of Cave-Dwelling Chelodesmidae (Diplopoda, Polydesmida), Rodrigo Salvador Bouzan, Jackson C. Means, Kaloyan Ivanov, Rodrigo L. Ferreira, Antonio Domingos Brescovit, Luiz Felipe Moretti Iniesta

International Journal of Speleology

Chelodesmidae is one of the most species rich families within the Myriapoda. However, little is known regarding their association with caves. We provide a list of all Chelodesmidae taxa reported from caves, map their worldwide distribution, and discuss the troglomorphic features of the group. A total of 25 species and subspecies from 20 genera and 2 subfamilies have been recorded from 59 caves and cave systems in 11 countries. These numbers represent a surprisingly modest proportion (~3%) of the approximately 800 described species in the family. Records of cave-dwelling chelodesmids appear to be geographically biased with most taxa reported from …

Simulated Problem-Based Learning: Teaching International Law In Exciting Way, Nik Nor Suhaida Ali

Indonesian Journal of International Law

This research aimed to discuss the methods for teaching International Law to non-law students. The subject was offered to second and third-year students of the International Affairs Management program at the School of International Studies, Universiti Utara Malaysia. Since the subject required higher-order thinking skills, it was introduced with Simulated Problem-Based Learning (SPBL), which combines role-playing simulation and problem-based learning (PBL). In western universities, simulations, PBL, and role-playing were popular methods in teaching International Law and International Relations. The methods were shown to improve learning skills but were rarely used in teaching International Law in International Relations programs in Malaysia. …

Teaching International Human Rights Law In Vietnam: How To Make This Subject Attractive To University Students, Nguyen Thi Ha

Indonesian Journal of International Law

Human Rights is one of the achievements of the historical development of mankind, characteristic of civilized society, and also one of the basic and important legal values of humanity.

In the context of international integration of education in general and higher education in particular, the teaching of human rights, first of all, international human rights law is important for undergraduate students, especially in helping them to identify and understand the responsibility to make human rights become a reality in society. Human rights teaching aims to help learners orient and understand noble human values, common voices, common goals, and common means …

Teaching Public International Law In Central Asia: Major Challenges, Problematic Issues, Coping Strategies And Useful Methods, Rustam Bakhtiyarovich Atadjanov

Indonesian Journal of International Law

Many of the challenges pertaining to the unique nature of international law that affect its efficient teaching by teachers of public international law to law university and law faculty students are very relevant to the still developing educational systems of the five Central Asian states. The article reviews, with the use of legal analytical and comparative method, those challenges including the ones that flow out of local contextual factors. Furthermore, the existing lack of private universities and availability of resources including library resources in the Central Asian region will be touched upon. The article dwells on local schools and doctrines …

Hate-Clipper: Multimodal Hateful Meme Classification Based On Cross-Modal Interaction Of Clip Features, Gokul Karthik Kumar, Karthik Nandakumar

Computer Vision Faculty Publications

Hateful memes are a growing menace on social media. While the image and its corresponding text in a meme are related, they do not necessarily convey the same meaning when viewed individually. Hence, detecting hateful memes requires careful consideration of both visual and textual information. Multimodal pretraining can be beneficial for this task because it effectively captures the relationship between the image and the text by representing them in a similar feature space. Furthermore, it is essential to model the interactions between the image and text features through intermediate fusion. Most existing methods either employ multimodal pre-training or intermediate fusion, …

Occupational Therapy Program Research Seminar, Kelly L. Taylor Otd, Ms, Otr/L, Cbis

Student Scholarship & Creative Works

Occupational Therapy Program Research Seminar

December 7, 2022 │ 8:30AM – 12:30PM

Murray State University, Paducah Regional Campus

Births In The Mountain West, 2016-2020, Corryn Richardson, Hira Ahmed, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet examines state-level data on births and health indicators from the National Center for Health Statistics (NCHS), a government health statistics unit of the Center for Disease Control and Prevention (CDC). This fact sheet presents data related to births in the Mountain West states of Arizona, Colorado, New Mexico, Nevada, and Utah.