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2022

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The Effects Of Strength, Flexibility, And Aerobic Training On The Management And Improvement Of Symptoms Of Fibromyalgia In Women: A Systematic Review., Lainey Whittle Dec 2022

The Effects Of Strength, Flexibility, And Aerobic Training On The Management And Improvement Of Symptoms Of Fibromyalgia In Women: A Systematic Review., Lainey Whittle

Honors Theses

No abstract provided.


Do Adverse Childhood Experiences Increase The Likelihood Of High School Suspension?, Ashley Kernan, Melissa Jones, Hayley Pierce Dec 2022

Do Adverse Childhood Experiences Increase The Likelihood Of High School Suspension?, Ashley Kernan, Melissa Jones, Hayley Pierce

FHSS Mentored Research Conference

Scholars have found that adverse childhood experiences (ACEs) are associated with a wide variety of negative health and behavior outcomes during adolescence. However, significantly less research has examined how ACEs may influence the risk of being suspended from school during high school. Thus, the purpose of this study is to examine the relationship between cumulative, cluster and individual adverse childhood experiences (ACEs) and high school suspension. Data comes from the 2022 Florida Youth Substance Abuse Survey (FYSAS). The sample consists of 23,078 high schoolers from grades 9-12th. Logistic regressions were run to examine the association between ACEs and …


Determinism Beyond Time Evolution, Emily Adlam Dec 2022

Determinism Beyond Time Evolution, Emily Adlam

Mathematics, Physics, and Computer Science Faculty Articles and Research

Physicists are increasingly beginning to take seriously the possibility of laws outside the traditional time-evolution paradigm; yet many popular definitions of determinism are still predicated on a time-evolution picture, making them manifestly unsuited to the diverse range of research programmes in modern physics. In this article, we use a constraint-based framework to set out a generalization of determinism which does not presuppose temporal evolution, distinguishing between strong, weak and delocalised holistic determinism. We discuss some interesting consequences of these generalized notions of determinism, and we show that this approach sheds new light on the long-standing debate surrounding the nature of …


Exploring The Effectiveness Of The Grizzly Success Program At Georgia Gwinnett College: A Quantitative Study, Michael Phillip Poll Dec 2022

Exploring The Effectiveness Of The Grizzly Success Program At Georgia Gwinnett College: A Quantitative Study, Michael Phillip Poll

Theses and Dissertations

Research suggests that summer bridge programs are a successful strategy for helping at-risk students succeed in college by offering additional tutoring, mentoring, and advising (Slade et al., 2015). Bridge programs are effective for increasing student success (Bir & Myrick, 2015). However, summer bridge programs may challenge at-risk first-generation students due to limited access and additional fees (Mullen, 2010). The additional costs associated with summer programs combined with the summertime commitment needed for summer bridge programs may present a barrier to enrollment and prove difficult for at-risk students to overcome. Grizzly Success is a program that provides additional academic support, social …


Improving Spatial Resolution Of Time Reversal Focusing Using Arrays Of Acoustic Resonators, Adam David Kingsley Dec 2022

Improving Spatial Resolution Of Time Reversal Focusing Using Arrays Of Acoustic Resonators, Adam David Kingsley

Theses and Dissertations

Using a near-field array of acoustic resonators, it is possible to modify a focused pressure field and enforce a spatial frequency corresponding to the resonator array spacing. This higher spatial frequency makes it possible to focus and image with a resolution that is better than if the focusing were in free space. This near-field effect is caused by the phase shifting properties of resonators and, specifically, the delayed phase found in waves with a temporal frequency lower than that of the resonators in the array. Using time reversal, arrays of resonators are explored and the subwavelength focusing is used to …


Reserve Bank Of India Signs Bilateral Swap Agreement With Maldives Monetary Authority, Reserve Bank Of India Dec 2022

Reserve Bank Of India Signs Bilateral Swap Agreement With Maldives Monetary Authority, Reserve Bank Of India

Documents

No abstract provided.


Court Ruling In Dispute Between Reap And Ex-Bankers Kargins And Krasovickis Takes Effect, The Baltic Times Dec 2022

Court Ruling In Dispute Between Reap And Ex-Bankers Kargins And Krasovickis Takes Effect, The Baltic Times

Documents

No abstract provided.


“Surfaces And Appearances”: Character, Physiognomy, And Communication In Charles Dickens’S And Wilkie Collins’S A Message From The Sea, Rachel Gouff Dec 2022

“Surfaces And Appearances”: Character, Physiognomy, And Communication In Charles Dickens’S And Wilkie Collins’S A Message From The Sea, Rachel Gouff

Undergraduate Honors Theses

This thesis analyzes the way physiognomy works within Charles Dickens’s and Wilkie Collins’s novella, A Message from the Sea. The novella develops and promotes a version of physiognomy with limits, illustrating these limits through the experiences of its characters and through the symbolism of various objects such as tombstones, ghosts, and—most notably—the message in the bottle. Physiognomy, used repeatedly by various characters throughout the text, is nearly always able to correctly predict people’s general moral character. However, using physiognomy alone leaves a character’s history, motivations, and deep emotions as indecipherable as the parts of the bottle’s message where the ink …


Peer Reference & Beyond: Cultivating Community In An Information Literacy Program, Lydia C. Gwyn Dec 2022

Peer Reference & Beyond: Cultivating Community In An Information Literacy Program, Lydia C. Gwyn

ETSU Faculty Works

Today's objectives:

  1. Peer-reference programs: what are they? What do they look like...in libraries in general and at the Sherrod Library?
  2. The Library Ambassador Program (the LAP): as community cultivator among students in the program and the college at large.


The Montclarion, December 08, 2022, The Montclarion Dec 2022

The Montclarion, December 08, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University


Plasmon-Enhanced Quantitative Lateral Flow Assay For Detection Of Neisseria Gonorrhoeae, Jiaqi Wang Dec 2022

Plasmon-Enhanced Quantitative Lateral Flow Assay For Detection Of Neisseria Gonorrhoeae, Jiaqi Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

(ng)感染是最常见的性传播感染(STI)之一2020年,CDC共677,769例淋病。。。常常因对抗对抗耐药性高度易受到受到困扰困扰。。。因此因此因此因此因此因此因此因此因此快速准确地地检测检测淋病淋病就尤为尤为重要重要淋病的,但其试验时间长费用高的特点为加强加强全球淋病淋病淋病淋病防治防治工作工作工作工作工作工作淋病淋病淋病淋病淋病淋病淋病淋病淋病淋病感染感染感染感染感染,研制淋病感染感染研制研制研制研制一种灵敏,,特异特异,,迫切需要需要发明发明是基石,它基石,廉价廉价敏感。这工作中中中中,我们我们项项,我们我们了了了了了一种所有所有所有所有所有所有所有所有。我们用等离子体光做为超亮光标记,以克服依赖传统金纳米颗粒做为比色标记的横向流动分析的有限度。


Transition Guide And Supports For Families Of Adolescents With Disabilities, Chelsey S. Traut Dec 2022

Transition Guide And Supports For Families Of Adolescents With Disabilities, Chelsey S. Traut

Dissertations, Theses, and Projects

Often when individuals with disabilities transitioned out of high school, there were a variety of repeated questions that teachers and administrators seemed to constantly be answering each year. The first goal of the project was to answer those questions and potentially serve as a resource for teachers and other professionals to answer the questions parents/guardians were asking them. Another goal was that even if the information was different for their district it could at the very least guide professionals and families in the right direction to find answers and support. The literature review provides information about parent/guardian and teacher collaboration …


Impact Of Daca On Education & Employment And The Need For A Permanent Solution, Autumn Roemer Dec 2022

Impact Of Daca On Education & Employment And The Need For A Permanent Solution, Autumn Roemer

Honors Theses

On June 15, 2012 the Department of Homeland Security announced Deferred Action for Childhood Arrivals (DACA), an executive order from the President Barack Obama Administration, providing relief for undocumented immigrants who arrived in the U.S. when they were children. The move followed decades of litigation and failed actions in Congress, such as the Development, Relief, and Education for Alien Minors (DREAM) Act, attempting to address the group, known as DREAMers. DACA itself has also faced numerous challenges concerning its legality and application, the most recent of which have declared the program illegal, resulting in a halt on new applications and …


Missionaries And Manipulation: Exploring Vulnerabilities And Safeguards For Young Missionaries In The Church Of Jesus Christ Of Latter-Day Saints, Rachel Sowa Ray Dec 2022

Missionaries And Manipulation: Exploring Vulnerabilities And Safeguards For Young Missionaries In The Church Of Jesus Christ Of Latter-Day Saints, Rachel Sowa Ray

Undergraduate Honors Theses

This project aims to better understand the vulnerabilities of missionaries of the Church of Jesus Christ of Latter-day Saints as they relate to emotional abuse stemming from companions, mission leaders, and those they teach. It compiles the current research on relationship abuse and draws connections between these issues and missionaries. Emotional abuse is defined. We review various elements of missionary life, including the age of missionaries, religious pressures, pressures inherent in missionary life, and cultural naiveté. Each of these is tied to potential weaknesses in which emotional abuse can impact the life and relationships of a missionary. Suggestions for safeguards …


The Cowl - V. 87 N. 9 - December 8, 2022 Dec 2022

The Cowl - V. 87 N. 9 - December 8, 2022

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 9 - December 8, 2022. 24 pages.


Faculty Senate Executive Committee Agenda, December 12, 2022, Utah State University Dec 2022

Faculty Senate Executive Committee Agenda, December 12, 2022, Utah State University

Faculty Senate & Faculty Senate Executive Committee

  • Call to Order: Approval of Minutes- Nov 14, 2022
  • University Business
  • Information: Educational Policies Committee
  • Reports: Council on Teacher Education; Scholarship Advisory Board
  • Old Business: Athletic Spending
  • New Business: Divestment Proposal
  • Adjourn


Friction Taper Plug Welding As A Repair Method For Fatigue Damage Around Fastener Holes In Aerospace Structures, David Carl Sumsion Dec 2022

Friction Taper Plug Welding As A Repair Method For Fatigue Damage Around Fastener Holes In Aerospace Structures, David Carl Sumsion

Theses and Dissertations

This work details an adaptation of the friction taper plug welding (FTPW) process to repair fatigue damage in 6.35mm AA 7050 t-7451 plate. Aircraft components experience fatigue damage around fastener holes. This damage can be mitigated by enlarging fastener holes. There is no effective repair procedure once holes reach a maximum allowable size. Damaged components must be replaced. A suitable repair process would lead to substantial savings in both time and money. A simulated repair process was developed by machining holes in 6.35mm AA 7050 t-7451 plate. These hoes were then plugged using the FTPW process. Microhardness testing and metallographic …


Safety Of Lenadogene Nolparvovec Gene Therapy Over 5 Years In 189 Patients With Leber Hereditary Optic Neuropathy, Catherine Vignal-Clermont, Patrick Yu-Wai-Man, Nancy J. Newman, Valerio Carelli, Mark L. Moster, Valerie Biousse, Prem S. Subramanian, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Alfredo A. Sadun, Thomas Klopstock, Robert C. Sergott, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Magali Taiel, Michel Roux, José-Alain Sahel Dec 2022

Safety Of Lenadogene Nolparvovec Gene Therapy Over 5 Years In 189 Patients With Leber Hereditary Optic Neuropathy, Catherine Vignal-Clermont, Patrick Yu-Wai-Man, Nancy J. Newman, Valerio Carelli, Mark L. Moster, Valerie Biousse, Prem S. Subramanian, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Alfredo A. Sadun, Thomas Klopstock, Robert C. Sergott, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Magali Taiel, Michel Roux, José-Alain Sahel

Wills Eye Hospital Papers

Purpose

To evaluate the safety profile of lenadogene nolparvovec (Lumevoq) in patients with Leber hereditary optic neuropathy.

Design

Pooled analysis of safety data from 5 clinical studies.

Methods

A total of 189 patients received single unilateral or bilateral intravitreal injections of a recombinant adeno-associated virus 2 (rAAV2/2) vector encoding the human wild-type ND4 gene. Adverse events (AEs) were collected throughout the studies, up to 5 years. Intraocular inflammation and increased intraocular pressure (IOP) were ocular AEs of special interest. Other assessments included ocular examinations, vector bio-dissemination, and systemic immune responses against rAAV2/2.

Results

Almost all patients (95.2%) received 9 × …


Strategies In Toefl Reading Comprehension For Chinese Students, Xiwen Li Dec 2022

Strategies In Toefl Reading Comprehension For Chinese Students, Xiwen Li

Master's Projects and Capstones

With China’s development, an increasing number of students choose to further their studies abroad. However, many Chinese students do not know how to prepare for the TOEFL test by themselves.Thus, there are three sections in my literature review, which are the introduction of TOEFL, TOEFL Reading Comprehension Strategies for Native Chinese Speakers, and TOEFL test preparation for Chinese students.After that, this project includes original materials so that beginning level students can get a preliminary understanding of the TOEFL reading comprehension tests. The material is deliberately based on Chinese culture, which makes it relevant and easier for beginners to understand. This …


Focusing Of High-Amplitude Sound Waves Using The Time Reversal Process, Brian D. Patchett Dec 2022

Focusing Of High-Amplitude Sound Waves Using The Time Reversal Process, Brian D. Patchett

Theses and Dissertations

Time reversal is a method often used to focus sound to a desired location, and works best in a reverberant environment. The effect of focus location within a reverberant environment is presented first, revealing that proximity to reflecting surfaces has a significant effect on the amplitude of the focus both experimentally and when using a modal summation model. These effects are a primary component to creating focus signals at high amplitudes. High-amplitude focusing experiments show that when multiple sources are used simultaneously to generate a focus, a peak amplitude pressure spike of 200 dB can be achieved in air. A …


The Resident View In Community- Based Care Residential Settings, Diana L. White, Ozcan Tunalilar, Serena Hasworth, Jaclyn Winfree Dec 2022

The Resident View In Community- Based Care Residential Settings, Diana L. White, Ozcan Tunalilar, Serena Hasworth, Jaclyn Winfree

Institute on Aging Publications

The Resident VIEW is a measure of person-centered care (PCC) from residents’ perspectives and was previously studied in nursing homes. The current study presents descriptive data for the Resident VIEW in community-based care settings including assisted living, residential care (AL/RC), and adult foster homes (AFH). Using a two-stage sampling design, we recruited 31 AL/RC and 119 AFH in Oregon and completed face-to-face structured interviews with 227 and 195 residents, respectively. Residents provided ratings for both the importance of and their experience with 66 items that tapped into PCC practices in eight domains. Results are provided for each item, many of …


Self-Efficacy, Knowledge, And Social Support On Self-Care Among Senior Korean Immigrants With Diabetes, Jung Eun Kim Dec 2022

Self-Efficacy, Knowledge, And Social Support On Self-Care Among Senior Korean Immigrants With Diabetes, Jung Eun Kim

Dissertations

Diabetes is a prevalent chronic disease that significantly affects morbidity and mortality among senior people. There are diverse ethnic populations in the United States, and Korean immigrants are one of the minority immigrant groups. Many senior Korean immigrants report language inadequacy, lack of social support, discrimination, anxiousness in an unfamiliar environment, and poor economic status. These barriers limit them from accessing adequate health care services and resources. Although self-care is the most important key part in managing diabetes, senior Korean immigrants with diabetes face challenges to perform effective self-care activities related to various barriers. However, studies about related factors on …


Development Of A 3d-Printed Microfluidic Droplet-On-Demand System For The Deterministic Encapsulation And Processing Of Biological Materials, Chandler A. Warr Dec 2022

Development Of A 3d-Printed Microfluidic Droplet-On-Demand System For The Deterministic Encapsulation And Processing Of Biological Materials, Chandler A. Warr

Theses and Dissertations

The growing threat of antimicrobial resistance is among the largest concerns in the world today. One method under development to combat this issue is the encapsulation of microbes in microfluidic droplets for single-cell testing. This method may be able to circumvent the need for a traditional positive cell culture which consumes the majority of the testing time using current diagnostic methods. This dissertation presents a method by which to deterministically encapsulate microbes using an artificial intelligence object detection algorithm and a Droplet-On-Demand microfluidic device. To accomplish this, the Droplet-On-Demand microfluidic device was first developed using a unique 3D-printing manufacturing method. …


Hardships, Motivations, And Resiliency: Case Study Of Health Implications Of 2022 Russian Invasion On Ukrainian Resistance Members, Jessi Hanson-Defusco Dec 2022

Hardships, Motivations, And Resiliency: Case Study Of Health Implications Of 2022 Russian Invasion On Ukrainian Resistance Members, Jessi Hanson-Defusco

Journal of Social, Behavioral, and Health Sciences

The 2022 Russian full-scale invasion of Ukraine caused millions of Ukrainians to flee. Yet most citizens continue to reside in the country, playing critical roles in the Ukrainian resistance. Today the Ukrainian fighting force includes trained military and police as well as citizens who either were conscripted or volunteered to take part in national war efforts. This mixed-method study conducted in Spring 2022 presents data collected from 79 respondents in a semistructured survey, using snowball sampling. Data analysis examined individual self-reported motivations, attitudes toward the conflict, resilience, quality-of-life hardships, and scaled perceived stress. Results indicated that Ukrainian resistance members face …


Enhanced Neurologic Concept Recognition Using A Named Entity Recognition Model Based On Transformers, Sima Azizi, Daniel B. Hier, Donald C. Wunsch Dec 2022

Enhanced Neurologic Concept Recognition Using A Named Entity Recognition Model Based On Transformers, Sima Azizi, Daniel B. Hier, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

Although Deep Learning Has Been Applied to the Recognition of Diseases and Drugs in Electronic Health Records and the Biomedical Literature, Relatively Little Study Has Been Devoted to the Utility of Deep Learning for the Recognition of Signs and Symptoms. the Recognition of Signs and Symptoms is Critical to the Success of Deep Phenotyping and Precision Medicine. We Have Developed a Named Entity Recognition Model that Uses Deep Learning to Identify Text Spans Containing Neurological Signs and Symptoms and Then Maps These Text Spans to the Clinical Concepts of a Neuro-Ontology. We Compared a Model based on Convolutional Neural Networks …


Methylprednisolone For Heart Surgery In Infants - A Randomized, Controlled Trial, Kevin D Hill, Prince J Kannankeril, Jeffrey P Jacobs, H Scott Baldwin, Marshall L Jacobs, Sean M O'Brien, David P Bichel, Eric M Graham, Brian Blasiole, Ashraf Resheidat, Adil S Husain, S Ram Kumar, Jerry L Kirchner, Dianne S Gallup, Joseph W Turek, Mark Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H Van Bergen, David Overman, Pirooz Eghtesady, Ryan Butts, John S Kim, John P Scott, Brett R Anderson, Michael F Swartz, Patrick I Mcconnell, David F Vener, Jennifer S Li, Stress Network Investigators Dec 2022

Methylprednisolone For Heart Surgery In Infants - A Randomized, Controlled Trial, Kevin D Hill, Prince J Kannankeril, Jeffrey P Jacobs, H Scott Baldwin, Marshall L Jacobs, Sean M O'Brien, David P Bichel, Eric M Graham, Brian Blasiole, Ashraf Resheidat, Adil S Husain, S Ram Kumar, Jerry L Kirchner, Dianne S Gallup, Joseph W Turek, Mark Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H Van Bergen, David Overman, Pirooz Eghtesady, Ryan Butts, John S Kim, John P Scott, Brett R Anderson, Michael F Swartz, Patrick I Mcconnell, David F Vener, Jennifer S Li, Stress Network Investigators

Faculty, Staff and Students Publications

BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown.

METHODS: We conducted a multicenter, prospective, randomized, placebo-controlled, registry-based trial involving infants (age) undergoing heart surgery with cardiopulmonary bypass at 24 sites participating in the Society of Thoracic Surgeons Congenital Heart Surgery Database. Registry data were used in the evaluation of outcomes. The infants were randomly assigned to receive prophylactic methylprednisolone (30 mg per kilogram of body weight) or placebo, which was administered into the cardiopulmonary-bypass pump-priming fluid. The primary end point was a ranked composite …


University Of Northern Iowa Graduate Council Minutes, December 8, 2022, University Of Northern Iowa. Graduate Council. Dec 2022

University Of Northern Iowa Graduate Council Minutes, December 8, 2022, University Of Northern Iowa. Graduate Council.

Documents - Graduate Council

Meeting minutes from the Graduate Council of the University of Northern Iowa.


Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M Wheeler, Adrienne M Stilp, Shuquan Rao, Bjarni V Halldórsson, Doruk Beyter, Jia Wen, Anna V Mihkaylova, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Aakrosh Ratan, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner Dec 2022

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M Wheeler, Adrienne M Stilp, Shuquan Rao, Bjarni V Halldórsson, Doruk Beyter, Jia Wen, Anna V Mihkaylova, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Aakrosh Ratan, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner

Faculty, Staff and Student Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative traits …


Lpa Disruption With Aav-Crispr Potently Lowers Plasma Apo(A) In Transgenic Mouse Model: A Proof-Of-Concept Study, Alexandria M Doerfler, So Hyun Park, Julia M Assini, Amer Youssef, Lavanya Saxena, Adam B Yaseen, Marco De Giorgi, Marcel Chuecos, Ayrea E Hurley, Ang Li, Santica M Marcovina, Gang Bao, Michael B Boffa, Marlys L Koschinsky, William R Lagor Dec 2022

Lpa Disruption With Aav-Crispr Potently Lowers Plasma Apo(A) In Transgenic Mouse Model: A Proof-Of-Concept Study, Alexandria M Doerfler, So Hyun Park, Julia M Assini, Amer Youssef, Lavanya Saxena, Adam B Yaseen, Marco De Giorgi, Marcel Chuecos, Ayrea E Hurley, Ang Li, Santica M Marcovina, Gang Bao, Michael B Boffa, Marlys L Koschinsky, William R Lagor

Faculty, Staff and Students Publications

Lipoprotein(a) (Lp(a)) represents a unique subclass of circulating lipoprotein particles and consists of an apolipoprotein(a) (apo(a)) molecule covalently bound to apolipoprotein B-100. The metabolism of Lp(a) particles is distinct from that of low-density lipoprotein (LDL) cholesterol, and currently approved lipid-lowering drugs do not provide substantial reductions in Lp(a), a causal risk factor for cardiovascular disease. Somatic genome editing has the potential to be a one-time therapy for individuals with extremely high Lp(a). We generated an LPA transgenic mouse model expressing apo(a) of physiologically relevant size. Adeno-associated virus (AAV) vector delivery of CRISPR-Cas9 was used to disrupt the LPA transgene in …


Trends In Esophageal Adenocarcinoma And Esophageal Squamous Cell Carcinoma Incidence In The United States From 1992 To 2019, Kyle S Liu, Syed Ahsan Raza, Hashem B El-Serag, Aaron P Thrift Dec 2022

Trends In Esophageal Adenocarcinoma And Esophageal Squamous Cell Carcinoma Incidence In The United States From 1992 To 2019, Kyle S Liu, Syed Ahsan Raza, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

Simple Summary

The incidence of esophageal cancer overall has increased in the United States, driven by increasing rates of esophageal adenocarcinoma (EAC). However, whether rates of EAC are still rising is unclear. We examined trends in esophageal cancer overall and within important sub-groups of the population. We found that esophageal squamous cell carcinoma (ESCC) rates have been steadily declining, while EAC rates rose rapidly before stabilizing in 2000. The trend of decreasing incidence of ESCC was observed almost uniformly by age group, sex, and race/ethnicity, while trends in EAC rates varied across these sub-groups. A cohort effect for EAC was …