Digital Commons Network^™

Building A Skill, Susan Dumais

UNH Today Archive

No abstract provided.

On The Bookshelf And Streaming, Susan Dumais

UNH Today Archive

No abstract provided.

Does Receiving A Sars-Cov-2 Antibody Test Result Change Covid-19 Protective Behaviors? Testing Risk Compensation In Undergraduate Students With A Randomized Controlled Trial, Christina Ludema, Molly S Rosenberg, Jonathan T Macy, Sina Kianersi, Maya Luetke, Chen Chen, Lilian Golzarri-Arroyo, Erin Ables, Kevin Maki, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Risk compensation, or matching behavior to a perceived level of acceptable risk, can blunt the effectiveness of public health interventions. One area of possible risk compensation during the SARS-CoV-2 pandemic is antibody testing. While antibody tests are imperfect measures of immunity, results may influence risk perception and individual preventive actions. We conducted a randomized control trial to assess whether receiving antibody test results changed SARS-CoV-2 protective behaviors.

Purpose: Assess whether objective information about antibody status, particularly for those who are antibody negative and likely still susceptible to SARS-CoV-2 infection, increases protective behaviors. Secondarily, assess whether a positive antibody test …

A Flexible-Hazards Cure Model With Application To Patients With Soft Tissue Sarcoma, Can Xie, Xuelin Huang, Ruosha Li, Peter W T Pisters

Faculty, Staff and Student Publications

In medical research, it is often of great interest to have an accurate estimation of cure rates by different treatment options and for different patient groups. If the follow-up time is sufficiently long and the sample size is large, the proportion of cured patients will make the Kaplan-Meier estimator of survival function have a flat plateau at its tail, whose value indicates the overall cure rate. However, it may be difficult to estimate and compare the cure rates for all the subsets of interest in this way, due to the limit of sample sizes and curse of dimensionality. In the …

Comparison Of Qt And Qtc Interval Measurements From Bedside Electrocardiograms Between Expert Nurses, Bedside Nurses, And Computerized Measurements: A Pilot Study, Karolina Ho

Theses

Prolongation of the QT/QTc (heart rate corrected) >500 milliseconds (msec) measured on the electrocardiogram (ECG) in hospitalized patients is associated with torsade de pointes (TdP). While some bedside ECG monitors now offer continuous QT/QTc software, agreement of these measurements to bedside and/or expert nurses has not been evaluated. The purpose of this study was to compare QT/QTc measurements between expert nurses, bedside nurses, both using electronic calipers, and continuous computerized measurements.

On The Relationship Between Collagen- And Carbonate-Derived Carbon Isotopes With Implications For The Inference Of Carnivore Dietary Behavior, Larisa R. G. Desantis, Robert S. Feranec, John Southon, Thure E. Cerling, John Harris, Wendy Binder, Joshua E. Cohen, Aisling B. Farrell, Emily L. Lindsey, Julie Meachen, Frank Robin O'Keefe, Gary T. Takeuchi

Biology Faculty Works

Studies of Rancho La Brea predators have yielded disparate dietary interpretations when analyzing bone collagen vs. enamel carbonate—requiring a better understanding of the relationship between stable carbon isotopes in these tissues. Stable carbon isotope spacing between collagen and carbonate (Δ_ca-co) has also been used as a proxy for inferring the trophic level of mammals, with higher Δ_ca-co values indicative of high carbohydrate consumption. To clarify the stable isotope ecology of carnivorans, past and present, we analyzed bone collagen (carbon and nitrogen) and enamel carbonate (carbon) of extinct and extant North American felids and canids, including dire wolves, …

Correlations Between Complex Human Phenotypes Vary By Genetic Background, Gender, And Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, Han Chen, Alanna C Morrison, Paul S De Vries, Huichun Xu, Ani W Manichaikul, Xiuqing Guo, Nora Franceschini, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Donald M Lloyd-Jones, Myriam Fornage, Adolfo Correa, Nancy L Heard-Costa, Ramachandran S Vasan, Ryan Hernandez, Robert C Kaplan, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both heritabilities and genetic correlations for multiple phenotypes and phenotype pairs between individuals of self-reported Black, Hispanic/Latino, and White backgrounds. We similarly observe differences in many of the genetic and environmental correlations between genders. To estimate the contribution of genetics to the observed phenotypic correlation, we …

Strengthen Fundamental Role Of Data Element Governance In National Governance Modernization, Kaihua Chen, Zhuo Feng, Rui Guo, Yue Hao, Jin Kang, Xiaoguang Yang, Chao Zhang, Binbin Zhao

Bulletin of Chinese Academy of Sciences (Chinese Version)

Data element governance is a key factor to promote the modernization of national governance in the digital era. By strengthening the deep integration of data factors and national governance, a new model of data-driven national governance can be formed, and the national governance can be made more scientific, refined, intelligent, and efficient. The US and European countries have continuously strengthened the top-level system design, technological innovation application, collaborative governance mechanism, and global governance cooperation of data element governance, which has effectively improved the level of data element governance and provided experience for China. Nevertheless, due to the virtuality of data …

Strategic Perspective Of Leveraging New Generation Information Technology To Enable Modernization Of Emergency Management, Haibo Zhang, Xinyu Dai, Depei Qian, Jian Lyu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The application and development of the new generation information technology is a vital support to realize the modernization of emergency management. At present, the new generation information technology such as big data and artificial intelligence has been widely used in natural disasters, safe production, and other fields. It has improved the monitoring and early warning, regulation and law enforcement, command and decision support, rescue, and social mobilization capabilities of governments, promoted the level of intrinsic safety of enterprises, provided important support for the precise prevention and control of the COVID-19, and increased the efficiency of China’s emergency management and sense …

A Classical Model Of Speculative Asset Price Dynamics, Sabiou M. Inoua, Vernon L. Smith

ESI Working Papers

In retrospect, the experimental findings on competitive market behavior called for a revival of the old, classical, view of competition as a collective higgling and bargaining process (as opposed to price-taking behaviors) founded on reservation prices (in place of the utility function). In this paper, we specialize the classical methodology to deal with speculation, an important impediment to price stability. The model involves typical features of a field or lab asset market setup and lends itself to an experimental test of its specific predictions; here we use the model to explain three general stylized facts, well established both empirically and …

In-Depth Analysis Of Alternative Splicing Landscape In Multiple Myeloma And Potential Role Of Dysregulated Splicing Factors, Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Mehmet K Samur, Nikhil C Munshi

Faculty, Staff and Student Publications

Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We observed a large number of splicing pattern changes in MM cells compared to normal plasma cells (NPC). The most common events were alterations of mutually exclusive exons and exon skipping. Most of these events were observed in the absence of overall changes in gene expression and often impacted the coding potential of the alternatively spliced genes. To understand the molecular mechanisms driving frequent aberrant AS, we …

Labial Frenotomy For Symptomatic Isolated Upper Lip Tie, Cecilia G Freeman, Jason F Ohlstein, Nicholas A Rossi, John B Mcintire, Luis D Neve, Shiva Daram, Harold S Pine

Faculty, Staff and Student Publications

BACKGROUND: The benefits and challenges of successful breastfeeding for both mother and child have been well-established in the literature. While ankyloglossia, or tongue tie, alone or in combination with upper lip tie has been the focus of several previous studies, very few have directly addressed isolated symptomatic upper lip tie and the role of surgical correction for breastfeeding difficulties.

MATERIALS AND METHODS: Seven infants with isolated upper lip tie and breastfeeding difficulty were taken to the operating room for labial frenotomy. These infants were assessed at their follow-up visits for their degree of weight gain since their procedure. Their mothers …

Structural Insights Into Cardiolipin Replacement By Phosphatidylglycerol In A Cardiolipin-Lacking Yeast Respiratory Supercomplex, Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, Ana-Nicoleta Bondar, John L Spudich

Faculty, Staff and Student Publications

Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic silencing). KCRs are capable of discriminating K+ from Na+ without the conventional K+ selectivity filter found in classical K+ channels. The genome of H. catenoides also encodes a third paralog that is more permeable for Na+ than for K+. To identify structural motifs responsible for the unusual K+ selectivity of KCRs, we systematically analyzed a series of chimeras and mutants of this protein. We found that mutations of three critical residues in the …

Application Of Accuracy And Precision Evaluations Based On The Current United States And Indonesian Pharmacopoeias: A Critical Review, Gunawan Indrayanto

Makara Journal of Science

New methods for the evaluation of accuracy and precision are mentioned in the latest edition of the United States Pharmacopoeia (USP), whereas other validation parameters, that is, selectivity, linearity, range, and robustness, remained relatively unchanged. In obtaining reliable data from any chemical/pharmaceutical analysis, the analytical procedure must be validated or verified in accordance with the latest edition of the pharmacopoeia. Some review articles on the general validation methods have been published by the author. This present review will focus on the implementation and discussion of the accuracy and precision evaluation based on the current USP and Indonesian pharmacopoeia. Some examples …

Temperature Influence On The Optical Properties, Attenuation Coefficient, And Total Molecular Cross Section Of Dhunge Dhara Drinking Water, Saddam Husain Dhobi, Bibek Koirala, Kishori Yadav, Jeevan Jyoti Nakarmi, Suresh Prasad Gupta, Santosh Kumar Das, Arun Kumar Shah, Kuldip Paudel, Kushal Dahal, Ram Lal Sah

Makara Journal of Science

This work aims to measure the different parameters of Dhunge Dhara water (DDW) such as absorbance, transmittance, mass attenuation coefficient (MAC), and molecular cross section (MCS) and experimentally compare the obtained values with those of pure water (PW) at various temperatures (5 °C to 90 °C) using a theremino spectrometer. Observation shows that the parameters vary with temperature and wavelength. The transmittance of DDW ranges from 18% to 85% and absorbance of the same ranges from 0.09 Au to 0.7 Au. Meanwhile, the transmittance of PW ranges from 40% to 98% and the absorbance of the same ranges from 0.09 …

Cardiac Physical Exam Skills And Auscultation Session For Pediatric Interns, Christopher A Sumski, Anoop Singh, Amanda Rogers, Robert Treat, Charles Bergstrom

2020-Current year OA Pubs

INTRODUCTION: Physicians need adequate physical exam skills. Unfortunately, interns have variable physical exam skills, and teaching is often limited to rounds, an inconsistent setting. Physical exam skills, particularly those involving auscultation, require practice. Our goal was to create a cardiac physical exam workshop for pediatric interns that would improve their performance on an interactive assessment of their ability and understanding in physical exam and murmur interpretation.

METHODS: We completed a targeted needs assessment and then developed a 2-hour workshop on the pediatric cardiac physical exam targeted to pediatrics residents. The workshop included didactics, group discussion, and practice interpreting common pediatric …

Type Iv Pili Are A Critical Virulence Factor In Clinical Isolates Of Paenibacillus Thiaminolyticus, Christine Hehnly, Petra Erdmann Gilmore, R. Reid Townsend, David D. Limbrick, Et Al.

2020-Current year OA Pubs

Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hydrocephalus in these areas. Since many children with hydrocephalus suffer poor long-term outcomes despite surgical intervention, prevention of hydrocephalus remains paramount. Our previous studies implicated a novel bacterial pathogen, Paenibacillus thiaminolyticus, as a causal agent of neonatal sepsis and postinfectious hydrocephalus in Uganda. Here, we report the isolation of three

Self-Hybridization In Leishmania Major, Tiago R Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks

2020-Current year OA Pubs

Genetic exchange between different

A Unique High-Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance In Cantu Syndrome, Gautam K Singh, Conor Mcclenaghan, Manish Aggarwal, Hongjie Gu, Maria S Remedi, Dorothy K Grange, Colin G Nichols

2020-Current year OA Pubs

Background Cardiomegaly caused by left ventricular hypertrophy is a risk factor for development of congestive heart failure, classically associated with decreased systolic and/or diastolic ventricular function. Less attention has been given to the phenotype of left ventricular hypertrophy with enhanced ventricular function and increased cardiac output, which is potentially associated with high-output heart failure. Lack of recognition may pose diagnostic ambiguity and management complexities. Methods and Results We sought to systematically characterize high-output cardiac hypertrophy in subjects with Cantu syndrome (CS), caused by gain-of-function variants in

Estimating Abundance Of An Elusive Cetacean In A Complex Environment: Harbor Porpoises (Phocoena Phocoena) In Inland Waters Of Southeast Alaska, Alexandre N. Zerbini, Kimberly T. Goetz, Karin A. Forney, Charlotte Boyd

Faculty Research, Scholarly, and Creative Activity

The harbor porpoise (Phocoena phocoena) is common in temperate waters of the eastern North Pacific Ocean, including Southeast Alaska inland waters, a complex environment comprised of open waterways, narrow channels, and inlets. Two demographically independent populations are currently recognized in this region. Bycatch of porpoises in the salmon drift gillnet fisheries is suspected to occur regularly. In this study, we apply distance sampling to estimate abundance of harbor porpoise during ship surveys carried out in the summer of 2019. A stratified survey design was implemented to sample different harbor porpoise habitats. Survey tracklines were allocated following a randomized survey design …

Xcvatr: Detection And Characterization Of Variant Impact On The Embeddings Of Single -Cell And Bulk Rna-Sequencing Samples, Arif Harmanci, Akdes Serin Harmanci, Tiemo J Klisch, Akash J Patel

Duncan NRI Faculty and Staff Publications

Background: RNA-sequencing has become a standard tool for analyzing gene activity in bulk samples and at the single-cell level. By increasing sample sizes and cell counts, this technique can uncover substantial information about cellular transcriptional states. Beyond quantification of gene expression, RNA-seq can be used for detecting variants, including single nucleotide polymorphisms, small insertions/deletions, and larger variants, such as copy number variants. Notably, joint analysis of variants with cellular transcriptional states may provide insights into the impact of mutations, especially for complex and heterogeneous samples. However, this analysis is often challenging due to a prohibitively high number of variants and …

Human-Machine Communication: Complete Volume 5. Gender And Human-Machine Communication

Human-Machine Communication

This is the complete volume of HMC Volume 5

Gender Ambiguity In Voice-Based Assistants: Gender Perception And Influences Of Context, Sandra Mooshammer, Katrin Etzrodt

Human-Machine Communication

Recently emerging synthetic acoustically gender-ambiguous voices could contribute to dissolving the still prevailing genderism. Yet, are we indeed perceiving these voices as “unassignable”? Or are we trying to assimilate them into existing genders? To investigate the perceived ambiguity, we conducted an explorative 3 (male, female, ambiguous voice) × 3 (male, female, ambiguous topic) experiment. We found that, although participants perceived the gender-ambiguous voice as ambiguous, they used a profoundly wide range of the scale, indicating tendencies toward a gender. We uncovered a mild dissolve of gender roles. Neither the listener’s gender nor the personal gender stereotypes impacted the perception. However, …

Gender And Human-Machine Communication: Where Are We?, Leopoldina Fortunati, Autumn P. Edwards

Human-Machine Communication

In this introduction to the fifth volume of the journal Human-Machine Communication, we present and discuss the five articles focusing on gender and human-machine communication. In this essay, we will analyze the theme of gender, including how this notion has historically and politically been set up, and for what reasons. We will start by considering gender in in-person communication, then we will progress to consider what happens to gender when it is mediated by the most important ICTs that preceded HMC: the telephone, mobile phone, and computer-mediated communication (CMC). We outline the historical framework necessary to analyze the last section …

Physical Activity Independently Predicts Perceived Stress During The Covid-19 Pandemic In Private University Students, Curtis W. Brownell, Laura S. Kabiri, Cassandra S. Diep, Heidi Y. Perkins, Amanda M. Perkins-Ball, Augusto X. Rodriguez

International Journal of Exercise Science

International Journal of Exercise Science 15(7): 1680-1691, 2022. Physical activity has significantly declined during the COVID-19 pandemic. Declines in physical activity have correlated with increased levels of perceived stress, though studies examining physical activity and stress have failed to account for critical confounds. The present study aims to determine whether physical activity independently predicts perceived stress in students attending private four-year universities. Physical activity, socioeconomic status, resilience, gender, and perceived stress data were collected from 85 students and used in a multiple linear regression analysis. The regression model accounted for 43.5% of the variance in perceived stress (R2 = .462, …

Muscle Architecture And Strength Changes Induced By Different Resistance Training Frequencies And Detraining, Tiago Volpi Braz, Felipe Brigatto, Danilo Rodrigues Batista, Wellington Gonçalves Dias, Luan Oenning Col, Guilherme Borsetti Businari, Jhenipher Rosolem, Julio Benvenutti Bueno De Camargo, Paulo Henrique Barbosa, Charles Ricardo Lopes

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 1661-1679, 2022. The purpose of the present study was to investigate muscle thickness and strength outcomes of the quadriceps femoris induced by different resistance training (RT) frequencies and detraining. In addition, muscle architecture (MA) parameters were also assessed. Twenty-seven healthy resistance-trained subjects (men, n = 17; women, n = 10; 20.8 ± 1.9 years; RT experience = 3.3 ± 1.6 years) volunteered to participate in this study. One leg of each subject was randomly allocated into the 2 sessions per week condition (2x) and the contralateral leg was then placed in the 4 sessions …

Review Of A Revolution In Canvas: The Rise Of Women Artists In Britain And France, 1760-1830, By Paris A. Spies-Gans, Gabrielle Stecher

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Paris A. Spies-Gans, A Revolution on Canvas: The Rise of Women Artists in Britain and France, 1760-1830 by Gabrielle Stecher

Ripped From The Headlines: Teaching Lady Mary Wortley Montagu's Turkish Letters In The Context Of 21st-Century Controversies, Susan Spencer

ABO: Interactive Journal for Women in the Arts, 1640–1830

In the long shadow of 9/11 and the ongoing COVID pandemic, Lady Mary Wortley Montagu’s Turkish Embassy Letters connect with the lived experience of today’s students, especially the cluster of eight letters dated 1 April 1717. By emphasizing parallels between Montagu’s observations and the students’ own lives, The Turkish Embassy Letters can add a modern dimension to the eighteenth century in general, challenges of gender, and texts written in and about the Muslim world.

Teaching Eliza Fay's Original Letters From India (1817) Through Classroom Editing, Lacy Marschalk

ABO: Interactive Journal for Women in the Arts, 1640–1830

Travel writing is an ever-growing area of interest in eighteenth-century studies, but it can be difficult to teach. Students often find the writing dry and unrelatable, and faculty who have had little experience with travel writing in their own educations may not know which texts would prove useful to their courses. In this article, I discuss the travel narrative with which I've found the most pedagogical success, Eliza Fay's Original Letters from India (1817). Fay's initial journey to India includes a range of captivating adventures, including encounters with Marie Antoinette in Paris, bandits in Egypt, and Hyder Ali in Calicut, …

Taking Chardin's Kitchen Maids Seriously, Danielle Ezor

ABO: Interactive Journal for Women in the Arts, 1640–1830

Historically, Jean-Siméon Chardin’s The Kitchen Maid and Return from the Market have been characterized as austere images of middle-class virtue. However, the engravings made after these paintings include verses that place the paintings within the satirical tradition. Thus, there is a misalignment between the canonical interpretation of Chardin’s kitchen maids as virtuous and the satirical understanding of these paintings. I reconcile these two contradictory interpretations by offering a feminist reinterpretation of Chardin’s The Kitchen Maid and Return from the Market, juxtaposing the prints and their satirical verses and considering the female viewer. In my analysis, I focus on small, …