Digital Commons Network^™

Extracellular Vesicle Characteristics And Micro Rna Content In Cerebral Palsy And Typically Developed Individuals At Rest And In Response To Aerobic Exercise., Ivan Jose Vechetti Jr, Jessica Norrbom, Björn Alkner, Emma Hjalmarsson, Alexandra Palmcrantz, Eva Pontén, Jessica Pingel, Ferdinand Von Walden, Rodrigo Fernandez-Gonzalo

Department of Nutrition and Health Sciences: Faculty Publications

In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs. Nine adult individuals with CP performed a single exercise bout consisting of 45 min of Frame Running, and TD participants completed either 45 min of cycling (n = 10; TD EX) or were enrolled as controls with no exercise (n = 10; TD CON). Blood was drawn before and 30 min after exercise and analyzed for EV concentration, size, and microRNA …

Activation Of Basal Forebrain-To-Lateral Habenula Circuitry Drives Reflexive Aversion And Suppresses Feeding Behavior, Jessica L Swanson, Joshua Ortiz-Guzman, Snigdha Srivastava, Pey-Shyuan Chin, Sean W Dooling, Elizabeth Hanson Moss, Mikhail Y Kochukov, Patrick J Hunt, Jay M Patel, Brandon T Pekarek, Qingchun Tong, Benjamin R Arenkiel

Faculty, Staff and Student Publications

Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many of the neural circuits that drive more complex, non-homeostatic feeding that integrate valence and sensory cues (such as taste and smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit that directly modulates non-homeostatic feeding behavior. Using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the BF that project to the LHb, which responds to diverse sensory cues, including aversive and food-related …

Tennessee Annual Comprehensive Financial Report For The Fiscal Year Ended June 30, 2022, Tennessee. Department Of Finance & Administration.

Annual Comprehensive Financial Reports

No abstract provided.

Physical Model Of Cilia Motion, Toby Utterback

Mechanical Engineering and Materials Science Independent Study

The motion of cilia could be further understood by creating and analysing a large scale model with similar stiffness and property values. Varying amounts of vibrating HEXBUG robots, representing motion and active particles, were placed in series with different segment lengths connecting them. The oscillating motion of a ciliium was able to be replicated and analyzed using autotracing and autotracking programs. The amplitude of the model increased with increasing length, while increasing length had an inconclusive effect on period. Furthermore, the visual path of a marked end segment repeated with each oscillation recorded.

Development Of Tool To Measure Mechanics Of Cylindrical Soft Tissue Samples, Perry Brody

Mechanical Engineering and Materials Science Independent Study

The objective of this study was to develop a tool to measure the mechanics of cylindrical soft tissue samples, specifically applied to the mouse uterus. Specialized equipment is required to perform such testing at the desired scale and sensitivity. An adjustable fixture was developed to mount mouse uterine ring samples with a method that allowed us to perform tensile testing using the ElectroForce 3200 Mechanical Testing System. The geometric parameters of the sample were determined by front and side-angled cameras throughout the test. Using the collected force-displacement data from the ElectroForce and the video recordings, the mechanical response of tissue …

Effect Of Diabetes-Associated Mutations In Kir 6.2/Sur1 On Katp Channel Activities, Yunpeng Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Maturity Onset Diabetes of the Young (MODY) is a type of diabetes, distinct from either type I or type II, that happens before age 25 (MedlinePlus, 2022). Unlike the other two more common forms of diabetes, MODY is classified as a series of monogenetic disorders (American Diabetes Association Professional Practice Committee, 2021), caused by autosomal mutations. MODY is typically characterized by insufficient secretion of insulin, a similar symptom to type I diabetes, classified into 14 different types based on mutations found on different genes. Among them, subtypes 12 and 13, also called neonatal diabetes mellitus (NDM), are caused by gain-of-function …

Lindenwood Digest, December 21, 2022, Lindenwood College

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Knowing The Biosphere: Documentation, Specimens, Archives, And Names Reveal Environmental Change And Emerging Pathogens, Eric P. Hoberg, Valeria Trivellone, Joseph A. Cook, Jonathan L. Dunnum, Walter A. Boeger, Daniel R. Brooks, Salvatore J. Agosta, Jocelyn P. Colella

MANTER: Journal of Parasite Biodiversity

One Health programs and trajectories are now the apparent standard for exploring the occurrence and distribution of emerging pathogens and disease. By definition, One Health has been characterized as a broadly inclusive, collaborative, and transdisciplinary approach with connectivity across local to global scales, which integrates the medical and veterinary community to recognize health outcomes emerging at the environmental nexus for people, animals, plants, and their shared landscapes. One Health has been an incomplete model, conceptually and operationally, focused on reactive and response-based foundations, to limit the impact of emerging pathogens and emerging infectious diseases and, as such, lacks a powerful …

Gatekeeping Admissions: Access To Justice And Inclusive Admissions Processes, Sarah Kriekle

Dalhousie Journal of Legal Studies

Law schools are the gatekeepers to the legal profession, and there are multiple social barriers that impact access to a legal education across a proportionally diverse range of people. This article will first rely on existing literature to demonstrate why diversity in the legal profession is an access to justice issue and to illustrate the current homogeneity that exists within the profession. This article will then argue that two primary factors prevent law schools from attracting a more diverse student body. The first factor is the over-reliance on numerical statistics like grade point average (GPA) and Law School Admissions Test …

Mental Age V Chronological Age: Rethinking Our Approach To Criminal Responsibility For Developmentally Delayed Young Persons Under The Youth Criminal Justice Act, Michael Michel

Dalhousie Journal of Legal Studies

The Youth Criminal Justice Act (YCJA) is meant to ensure that only the most serious cases warrant imprisonment. Both in the pre- and post-trial stages of a criminal proceeding, the YCJA contains safeguards designed to divert youth away from correctional institutions and encourage the use of community-based services. Yet, for youth suffering from mental disorders or injuries that cause significant cognitive impairment, these safeguards can be inadequate, detrimental, or simply unavailable. To resolve this shortcoming, this article advocates using mental age, rather than chronological age, as the benchmark for determining criminal responsibility under the YCJA.

Weakly-Supervised Learning Method For The Recognition Of Potato Leaf Diseases, Junde Chen, Xiaofang Deng, Yuxin Wen, Weirong Chen, Adnan Zeb, Defu Zhang

Engineering Faculty Articles and Research

As a crucial food crop, potatoes are highly consumed worldwide, while they are also susceptible to being infected by diverse diseases. Early detection and diagnosis can prevent the epidemic of plant diseases and raise crop yields. To this end, this study proposed a weakly-supervised learning approach for the identification of potato plant diseases. The foundation network was applied with the lightweight MobileNet V2, and to enhance the learning ability for minute lesion features, we modified the existing MobileNet-V2 architecture using the fine-tuning approach conducted by transfer learning. Then, the atrous convolution along with the SPP module was embedded into the …

Perceived Barriers To Increasing Diversity Within Oculofacial Plastic Surgery, Johsias A. Maru, Nicole D. Carvajal, Alejandra G. De Alba Campomanes, Neeti Parikh, Davin C. Ashraf, Robert C. Kersten, Bryan J. Winn, M. Reza Vagefi, Seanna R. Grob

Journal of Academic Ophthalmology

Abstract

Purpose Physician diversity is limited in ophthalmology and oculofacial plastic surgery. Determination of barriers within the application process for oculofacial plastic surgery may help target efforts to improve the recruitment of underrepresented groups. This study aimed to illuminate perceived barriers to increasing diversity in oculofacial plastic surgery trainees, according to the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) fellows and fellowship program directors (FPDs).

Methods During the month of February 2021, we sent surveys out to 54 current oculofacial plastic surgery fellows and 56 FPDs at 56 oculofacial plastic surgery programs recognized by the ASOPRS nationwide using …

Migrant Visits Over Time: Ethnographic Returning And The Technological Turn, Loretta Baldassar

Research outputs 2022 to 2026

This paper reflects on four decades of research (via ethnographic returning) to explore the social transformations in travel and communication technologies that have impacted the lived experiences, and consequently the theoretical conceptualization, of migrant visits. A comparison of migration waves between Italy and Australia reveals both continuities in visiting experience as deeply relational practices that facilitate a mutuality of being, but also transformations brought about by the technological turn. Visits take on different meanings depending on individual/ family life stage, generation, and community and national histories. The capacity for both physical and virtual copresence must be understood as coconstitutive, requiring …

Assessing The Influence Of Behavioural Parameterisation On The Dispersal Of Larvae In Marine Systems, M. K. James, J. A. Polton, C. G. Mayorga-Adame, K. L. Howell, A. M. Knights

School of Biological and Marine Sciences

Predicting dispersal and quantifying ecological connectivity are increasingly referenced as fundamental to understanding how biodiversity is structured across space and time. Dispersal models can provide insight, but their predictions are influenced by our capacity to simulate the biology and physics known to influence dispersal. In a marine context, vertical swimming behaviour is considered important in influencing the spatial organisation of species across seascapes, but the mechanisms underpinning these movements remain unresolved, making it unclear how best to incorporate behaviour within models. Here, using a 3-D hydrodynamic model coupled with a Lagrangian particle tracker, we show how different modelled larval behaviours, …

Dissecting The Recruitment And Self-Organization Of Αsma-Positive Fibroblasts In The Foreign Body Response, Maria Parlani, Matthew L Bedell, Antonios G Mikos, Peter Friedl, Eleonora Dondossola

Faculty, Staff and Student Publications

The foreign body response (FBR) is a clinically relevant issue that can cause malfunction of implanted medical devices by fibrotic encapsulation. Whereas inflammatory aspects of the FBR have been established, underlying fibroblast-dependent mechanisms remain unclear. We here combine multiphoton microscopy with ad hoc reporter mice expressing α-smooth muscle actin (αSMA) protein to determine the locoregional fibroblast dynamics, activation, and fibrotic encapsulation of polymeric materials. Fibroblasts invaded as individual cells and established a multicellular network, which transited to a two-compartment fibrotic response displaying an αSMA cold external capsule and a long-lasting, inner αSMA hot environment. The recruitment of fibroblasts and extent …

Reap Success From Persistence, Cuihong Tian, Jingyi Yan, Xuerui Tan, Wei Wang

Research outputs 2022 to 2026

The road to success is long and arduous. Almost all Nobel prize laureates experienced tremendous efforts and countless failures before they made their scientific breakthroughs. Hypothesis-driven, independent and critical thinking, passion, repeated experiments and repetitive failures and running in circles on the entire scientific process finally approved their hypotheses.

Patient-Centered Outcomes Of An Emergency Department Social And Medical Resource Intervention, Rohit Gupta, Anthony Wang, Daniel Wang, Daniela Ortiz, Karen Kurian, Thiago Halmer, Michael S Jaung

Faculty, Staff and Students Publications

INTRODUCTION: Few studies have examined the impact of emergency department (ED) social interventions on patient outcomes and revisits, especially in underserved populations. Our objective in this study was to characterize a volunteer initiative that provided community medical and social resources at ED discharge and its effect on ED revisit rates and adherence to follow-up appointments at a large, county hospital ED.

METHODS: We performed a cross-sectional analysis of ED patients who received medical and social resources and an educational intervention at discharge between September 2017-June 2018. Demographic information, the number of ED return visits, and outpatient follow-up appointment adherence within …

Fetal Brain Tumors, A Challenge In Prenatal Diagnosis, Counselling, And Therapy, Ivonne Alexandra Bedei, Thierry A G M Huisman, William Whitehead, Roland Axt-Fliedner, Michael Belfort, Magdalena Sanz Cortes

Faculty, Staff and Students Publications

Fetal brain tumors are a rare entity with an overall guarded prognosis. About 10% of congenital brain tumors are diagnosed during fetal life. They differ from the postnatally encountered pediatric brain tumors with respect to location and tumor type. Fetal brain tumors can be benign or malignant and infiltrate or displace adjacent brain structures. Due to their high mitotic rate, they can show rapid growth. Outcome depends on age of diagnosis, size, and histological tumor type. Findings like polyhydramnios and macrocephaly encountered on routine ultrasound are frequently associated. Detailed prenatal anomaly scan and subsequent fetal magnetic resonance imaging (MRI) may …

Author Correction: A Nanoengineered Topical Transmucosal Cisplatin Delivery System Induces Anti-Tumor Response In Animal Models And Patients With Oral Cancer, Manijeh Goldberg, Aaron Manzi, Amritpreet Birdi, Brandon Laporte, Peter Conway, Stefanie Cantin, Vasudha Mishra, Alka Singh, Alexander T Pearson, Eric R Goldberg, Sam Goldberger, Benjamin Flaum, Rifat Hasina, Nyall R London, Gary L Gallia, Chetan Bettegowda, Simon Young, Vlad Sandulache, James Melville, Jonathan Shun, Sonya E O'Neill, Erkin Aydin, Alex Zhavoronkov, Anxo Vidal, Atenea Soto, Maria Jose Alonso, Ari J Rosenberg, Mark W Lingen, Anil D'Cruz, Nishant Agrawal, Evgeny Izumchenko

Faculty, Staff and Student Publications

No abstract provided.

Influence Of Reading Habit On Perception And Use Of Reference Sources By Postgraduate Students In The Faculty Of Education Of Ibadan, Nigeria, Sunday A. Oluwaniyi, Lawrence Akingbade

Library Philosophy and Practice (e-journal)

Abstract

Libraries play a critical role in promoting reading habits. If postgraduate students cultivate the habits of reading, their perception and use of reference sources will be enhanced. The main objective is to determine the influence of reading habits on the perception and use of reference sources by postgraduates in the Faculty of Education, University of Ibadan. Descriptive survey research design was adopted for the study and the study population consisted of 2503 postgraduate students of the Faculty of Education, University of Ibadan, Nigeria, Stratified random sampling technique was used to select the sample size of 337 and tie questionnaire …

Expanded Proteomic Survey Of The Human Parasite Leishmania Major Focusing On Changes In Null Mutants Of The Golgi Gdp-Mannose/Fucose/Arabinopyranose Transporter, Gloria Polanco, Nichollas E Scott, Lon F Lye, Stephen M Beverley

2020-Current year OA Pubs

The trypanosomatid protozoan parasite

A Mobile Phone Text Messaging Intervention To Manage Fatigue For People With Multiple Sclerosis, Spinal Cord Injury, And Stroke: Development And Usability Testing, Kerri A. Morgan, Alex W K Wong, Kim Walker, Rachel Heeb Desai, Tina M Knepper, Pamela K Newland

2020-Current year OA Pubs

BACKGROUND: Fatigue significantly affects daily functioning in persons with disabilities. Fatigue management can be challenging, and the information provided during routine physician visits to manage fatigue can be overwhelming. One way to address fatigue is to increase knowledge, skills, and confidence for self-management (ie, patient activation). Self-management programs have shown promising effects in targeting fatigue in persons with disabilities. However, satisfaction with self-management programs is low for persons with disabilities, and tailoring interventions to personalized needs has been recommended. SMS text messaging is increasingly being used to implement health behavior change interventions in a person's natural environment. Little has been …

A Genome-Wide Association Study Of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants, Harold Bae, Ping An, Mary Feitosa, Et Al.

2020-Current year OA Pubs

We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls. The analysis identified a locus in CDKN2B-AS1 (rs6475609,

Review Of "Dying To Learn: Wartime Lessons From The Western Front" By Michael A. Hunzeker, Tim Cook

Canadian Military History

Review of Dying to Learn: Wartime Lessons from the Western Front by Michael A. Hunzeker.

An Educator’S Reflection On The Importance Of Embodiment, Imagination, And Liberation, Ashley N. Gibson

Journal of Multicultural Affairs

This reflection piece offers an interpretation of the years 2020-2021, through the earliest days of the COVID-19 pandemic and the racial awakenings in the US. Writing at the intersections of race, gender, and religion, this piece is part essay, part spoken word, and part treatise. The ultimate call to action is threefold; we must lean into embodiment as a habit for living, use our imaginations, and seek liberation for ourselves and one another if we are to hope for a better future. While many aspects of life now seem bleak, there is hope if we consider these three principles for …

Vol. 37 No. 3 - Whole No. 216, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 37 No. 2 - Whole No. 215, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Evaluating The Pro Se Plight: A Comprehensive Review Of Access To Justice Initiatives In Ohio Landlord-Tenant Law, Caleigh M. Harris

University of Cincinnati Law Review

No abstract provided.

Corporate Innovation: One Path To More Sustainable Big Business, David Nows

University of Cincinnati Law Review

No abstract provided.

Revisiting Employment Division V. Smith, Blaine L. Hutchison

University of Cincinnati Law Review

The Supreme Court wrongly decided Employment Division v. Smith. Without briefing or argument over the Free Exercise Clause’s meaning, Smith eliminated the constitutional right to exercise religion and replaced it with an equal protection rule. The decision threatens religious freedom and encourages conflict. The Supreme Court should revisit Smith. This article shows that the majority’s arguments in Smith fail and contradict the Free Exercise Clause’s text, purpose, and original meaning.

The Smith majority gave no sound legal or policy reason for its decision. Indeed, the decision conflicted with settled precedents that no party questioned. Nor did it determine …