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The Cowl - V. 87 N. 9 - December 8, 2022

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 9 - December 8, 2022. 24 pages.

Gary Grossman Oral History Interview, Gary Grossman, Mathew Lin

Raymond College

No abstract provided.

A Maturity Model Of Data Modeling In Self-Service Business Intelligence Software, Anna Kurenkov

Master of Science in Information Technology Theses

Although Self-Service Business Intelligence (SSBI) is continually being adopted in various industries, there is a lack of research focused on data modeling in SSBI. This research aims to fill that research gap and propose a maturity model for SSBI data modeling which is generalizeable between different software and applicable for users of all technical backgrounds. Through extensive literature review, a five-tier maturity model was proposed, explained, and instantiated in PowerBI and Tableau. The testing of the model was found to be simple and intuitive, and the research concludes that the model is applicable to enterprise SSBI environments. This research is …

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille

Nebraska Center for Virology: Faculty Publications

Moraxella bovis (M. bovis) is regarded as a causative agent of infectious bovine keratoconjunctivitis (IBK), the most common ocular disease of cattle. Recently, whole genome sequencing identified the presence of two distinct genotypes within M. bovis that differ in chromosome content, potential virulence factors, as well as prophage and plasmid profiles. It is unclear if the genotypes equally associate with IBK or if one is more likely to be isolated from IBK lesions. We utilized 39 strains of M. bovis that had previously undergone whole genome sequencing and genotype classification to determine the utility of matrix-assisted laser desorption/ionization …

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovis (M. bovis) is regarded as a causative agent of infectious bovine keratoconjunctivitis (IBK), the most common ocular disease of cattle. Recently, whole genome sequencing identified the presence of two distinct genotypes within M. bovis that differ in chromosome content, potential virulence factors, as well as prophage and plasmid profiles. It is unclear if the genotypes equally associate with IBK or if one is more likely to be isolated from IBK lesions. We utilized 39 strains of M. bovis that had previously undergone whole genome sequencing and genotype classification to determine the utility of matrix-assisted laser desorption/ionization …

Estimation Of Cotton Canopy Parameters Based On Unmanned Aerial Vehicle (Uav) Oblique Photography, Jinyong Wu, Sheng Wen, Yubin Lan, Xuanchun Yin, Jiantao Zhang, Yufeng Ge

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Background: The technology of cotton defoliation is essential for mechanical cotton harvesting. Agricultural unmanned aerial vehicle (UAV) spraying has the advantages of low cost, high efficiency and no mechanical damage to cotton and has been favored and widely used by cotton planters in China. However, there are also some problems of low cotton defoliation rates and high impurity rates caused by unclear spraying amounts of cotton defoliants. The chemical rate recommendation and application should be based upon crop canopy volume rather than on land area. Plant height and leaf area index (LAI) is directly connected to plant canopy structure. …

Safety Of Lenadogene Nolparvovec Gene Therapy Over 5 Years In 189 Patients With Leber Hereditary Optic Neuropathy, Catherine Vignal-Clermont, Patrick Yu-Wai-Man, Nancy J. Newman, Valerio Carelli, Mark L. Moster, Valerie Biousse, Prem S. Subramanian, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Alfredo A. Sadun, Thomas Klopstock, Robert C. Sergott, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Magali Taiel, Michel Roux, José-Alain Sahel

Wills Eye Hospital Papers

Purpose

To evaluate the safety profile of lenadogene nolparvovec (Lumevoq) in patients with Leber hereditary optic neuropathy.

Design

Pooled analysis of safety data from 5 clinical studies.

Methods

A total of 189 patients received single unilateral or bilateral intravitreal injections of a recombinant adeno-associated virus 2 (rAAV2/2) vector encoding the human wild-type ND4 gene. Adverse events (AEs) were collected throughout the studies, up to 5 years. Intraocular inflammation and increased intraocular pressure (IOP) were ocular AEs of special interest. Other assessments included ocular examinations, vector bio-dissemination, and systemic immune responses against rAAV2/2.

Results

Almost all patients (95.2%) received 9 × …

Investigating The Contribution Of Marine Viruses To Optical Backscatter In The <0.2 Μm Fraction Of Seawater, Kacey Mae Lange

Master's Theses

Marine viruses are the smallest and most abundant biological entities in the ocean. Marine viruses play a significant role in carbon and nutrient cycles through the liberation of dissolved organic matter (DOM) through the lysis of their numerically dominant hosts (i.e. bacteria and phytoplankton). Despite their importance, little is known about how viruses contribute to seawaters inherent optical properties (IOP) of seawater, specifically backscatter. All particles produce backscatter, with their contribution dependent on particle size, concentration, and composition. Living particles contribute 10-20% of the total backscatter with the remaining 80% of unclassified backscatter, “missing backscatter”, contributed by submicron particles ( …

Competitive Sustainability: The Intersection Of Sustainability And Business Success, Clyde Eiríkur Hull

Articles

Sustainability that beats the competition is different from sustainability that does not. Some who care very much about sustainability may not care at all about business success. However, they should. If businesses were to see that competitive sustainability leads to financial success, they would take it up and abandon nonsustainable practices

Strategies In Toefl Reading Comprehension For Chinese Students, Xiwen Li

Master's Projects and Capstones

With China’s development, an increasing number of students choose to further their studies abroad. However, many Chinese students do not know how to prepare for the TOEFL test by themselves.Thus, there are three sections in my literature review, which are the introduction of TOEFL, TOEFL Reading Comprehension Strategies for Native Chinese Speakers, and TOEFL test preparation for Chinese students.After that, this project includes original materials so that beginning level students can get a preliminary understanding of the TOEFL reading comprehension tests. The material is deliberately based on Chinese culture, which makes it relevant and easier for beginners to understand. This …

Gator2-Dependent Mtorc1 Activity Is A Therapeutic Vulnerability In Foxo1 Fusion-Positive Rhabdomyosarcoma, Jacqueline Morales, David V. Allegakoen, José A. Garcia, Kristen Kwong, Pushpendra K. Sahu, Drew A. Fajardo, Yue Pan, Max A. Horlbeck, Jonathan S. Weissman, W. Clay Gustafson, Trever G. Bivona, Amit J. Sabnis

Student Publications

Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor survival; to date, these cancer drivers are therapeutically intractable. To identify new therapies for this disease, we undertook an isogenic CRISPR-interference screen to define PAX3-FOXO1-specific genetic dependencies and identified genes in the GATOR2 complex. GATOR2 loss in RMS abrogated aa-induced lysosomal localization of mTORC1 and consequent downstream signaling, slowing G1-S cell cycle transition. In vivo suppression of GATOR2 impaired the growth of tumor xenografts and favored the outgrowth of cells lacking PAX3-FOXO1. Loss of a subset of GATOR2 members can be compensated by direct genetic activation of mTORC1. …

Focusing Of High-Amplitude Sound Waves Using The Time Reversal Process, Brian D. Patchett

Theses and Dissertations

Time reversal is a method often used to focus sound to a desired location, and works best in a reverberant environment. The effect of focus location within a reverberant environment is presented first, revealing that proximity to reflecting surfaces has a significant effect on the amplitude of the focus both experimentally and when using a modal summation model. These effects are a primary component to creating focus signals at high amplitudes. High-amplitude focusing experiments show that when multiple sources are used simultaneously to generate a focus, a peak amplitude pressure spike of 200 dB can be achieved in air. A …

Development Of A 3d-Printed Microfluidic Droplet-On-Demand System For The Deterministic Encapsulation And Processing Of Biological Materials, Chandler A. Warr

Theses and Dissertations

The growing threat of antimicrobial resistance is among the largest concerns in the world today. One method under development to combat this issue is the encapsulation of microbes in microfluidic droplets for single-cell testing. This method may be able to circumvent the need for a traditional positive cell culture which consumes the majority of the testing time using current diagnostic methods. This dissertation presents a method by which to deterministically encapsulate microbes using an artificial intelligence object detection algorithm and a Droplet-On-Demand microfluidic device. To accomplish this, the Droplet-On-Demand microfluidic device was first developed using a unique 3D-printing manufacturing method. …

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M. Wheeler, Adrienne M. Stilp, Shuquan Rao, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Laura Almasy, John Blangero, Joanne E. Curran

School of Medicine Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative …

Hardships, Motivations, And Resiliency: Case Study Of Health Implications Of 2022 Russian Invasion On Ukrainian Resistance Members, Jessi Hanson-Defusco

Journal of Social, Behavioral, and Health Sciences

The 2022 Russian full-scale invasion of Ukraine caused millions of Ukrainians to flee. Yet most citizens continue to reside in the country, playing critical roles in the Ukrainian resistance. Today the Ukrainian fighting force includes trained military and police as well as citizens who either were conscripted or volunteered to take part in national war efforts. This mixed-method study conducted in Spring 2022 presents data collected from 79 respondents in a semistructured survey, using snowball sampling. Data analysis examined individual self-reported motivations, attitudes toward the conflict, resilience, quality-of-life hardships, and scaled perceived stress. Results indicated that Ukrainian resistance members face …

Evidence-Based Study: The Effect Of The Covid-19 Pandemic On Post-Secondary Enrollment And Chosen Fields Of Study, Hannah Fields '25

Student Research

The onset of the COVID-19 pandemic in the United States in March of 2020 derailed educational systems at all levels. Specifically, at the post-secondary level, the pandemic sent many students online or forced them to take a fifth year to complete their degrees. As a result, post-secondary enrollment rates are likely to have dropped to reflect these changing post-COVID views surrounding education. Additionally, changing viewpoints about the essentiality of certain jobs and roles changed the chosen fields of study of these same students. Data for this study was collected by way of a short-scale meta-analysis, and enrollment rates were split …

250 E. Houston Invs. L.P. V. State Of N.Y. Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

197 Madison Holdings Llc V. Nys Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

Enhanced Neurologic Concept Recognition Using A Named Entity Recognition Model Based On Transformers, Sima Azizi, Daniel B. Hier, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

Although Deep Learning Has Been Applied to the Recognition of Diseases and Drugs in Electronic Health Records and the Biomedical Literature, Relatively Little Study Has Been Devoted to the Utility of Deep Learning for the Recognition of Signs and Symptoms. the Recognition of Signs and Symptoms is Critical to the Success of Deep Phenotyping and Precision Medicine. We Have Developed a Named Entity Recognition Model that Uses Deep Learning to Identify Text Spans Containing Neurological Signs and Symptoms and Then Maps These Text Spans to the Clinical Concepts of a Neuro-Ontology. We Compared a Model based on Convolutional Neural Networks …

Methylprednisolone For Heart Surgery In Infants - A Randomized, Controlled Trial, Kevin D Hill, Prince J Kannankeril, Jeffrey P Jacobs, H Scott Baldwin, Marshall L Jacobs, Sean M O'Brien, David P Bichel, Eric M Graham, Brian Blasiole, Ashraf Resheidat, Adil S Husain, S Ram Kumar, Jerry L Kirchner, Dianne S Gallup, Joseph W Turek, Mark Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H Van Bergen, David Overman, Pirooz Eghtesady, Ryan Butts, John S Kim, John P Scott, Brett R Anderson, Michael F Swartz, Patrick I Mcconnell, David F Vener, Jennifer S Li, Stress Network Investigators

Faculty, Staff and Students Publications

BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown.

METHODS: We conducted a multicenter, prospective, randomized, placebo-controlled, registry-based trial involving infants (age) undergoing heart surgery with cardiopulmonary bypass at 24 sites participating in the Society of Thoracic Surgeons Congenital Heart Surgery Database. Registry data were used in the evaluation of outcomes. The infants were randomly assigned to receive prophylactic methylprednisolone (30 mg per kilogram of body weight) or placebo, which was administered into the cardiopulmonary-bypass pump-priming fluid. The primary end point was a ranked composite …

Autonomous Gyroscopic 2-Wheel Differential Robot, Haruka Kido, James Vrtis, Luke Anderson, Tarek Elderini

Electrical Engineering Student Publications

This paper demonstrates the implementation of an autonomous gyroscopic 2-wheel differential robot, including a forward and inverse kinematics simulation in MatLAB, a test hardware robot and programmed demonstration of a simple move forward and spin left motion, and a final configuration of a complete square path based on programming kinematics, gyroscopic speed responses, and remote-control functionality.

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M Wheeler, Adrienne M Stilp, Shuquan Rao, Bjarni V Halldórsson, Doruk Beyter, Jia Wen, Anna V Mihkaylova, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Aakrosh Ratan, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner

Faculty, Staff and Student Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative traits …

The Protein Phosphatase 2a Holoenzyme Is A Key Regulator Of Starch Metabolism And Bradyzoite Differentiation In Toxoplasma Gondii, Jin-Lei Wang, Ting-Ting Li, Hany M Elsheikha, Qin-Li Liang, Zhi-Wei Zhang, Meng Wang, L David Sibley, Xing-Quan Zhu

2020-Current year OA Pubs

Phenotypic switching between tachyzoite and bradyzoite is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite Toxoplasma gondii. Although accumulation of cytoplasmic starch granules is a hallmark of the quiescent bradyzoite stage, the regulatory factors and mechanisms contributing to amylopectin storage in bradyzoites are incompletely known. Here, we show that T. gondii protein phosphatase 2A (PP2A) holoenzyme is composed of a catalytic subunit PP2A-C, a scaffold subunit PP2A-A and a regulatory subunit PP2A-B. Disruption of any of these subunits increased starch accumulation and blocked the tachyzoite-to-bradyzoite differentiation. PP2A contributes to the regulation of amylopectin metabolism via dephosphorylation …

The Role Of Mate Seeking Motives, Status Acquisition Motives, And Dark Personality In Predicting Responses To An Aggression-Provoking Situation, Savannah Merold

Dissertations

Aggressive behavior is associated with many adverse consequences, prompting extensive research on the potential adaptive functions of aggression. For example, there is evidence that aggression may be beneficial for attaining status and attracting a potential mate (e.g., Buss & Dedden, 1990; Daly & Wilson, 1988; Griskevicius et al., 2009). Additionally, several personality traits have been identified as robust predictors of aggressive behavior (e.g., psychopathic, Machiavellian, narcissistic, and sadistic traits; Chester et al., 2019; Neumann & Hare, 2008; Paulhus & Jones, 2017; Twenge & Campbell, 2003). These two research traditions (i.e., evolutionary and personality) have remained separate, with few studies combining …

The Expanding Marine Built Environment And Biofilm Formation Processes, Rachel Mugge

Dissertations

The marine built environment (i.e., places or things made or modified by humans) in the northern Gulf of Mexico is rapidly expanding and includes over 2,000 known historic shipwrecks, nearly 4,100 artificial reefs, and other built structures for natural resource extraction, marine aquaculture, renewable energy generation, munitions dumping areas, and commercial and recreational activities. While these structures have the potential to develop into artificial reefs, acting as biodiversity hotspots that provide food and shelter and facilitate organism transport, it is unclear how they affect biodiversity and ecosystem function in the marine environment. The success of artificial reefs to become ecosystems …

Brain Transplantation Of Genetically Corrected Sanfilippo Type B Neural Stem Cells Induces Partial Cross-Correction Of The Disease, Yewande Pearse, Don Clarke, Shih-Hsin Kan, Steven Q Le, Valentina Sanghez, Anna Luzzi, Ivy Pham, Lina R Nih, Jonathan D Cooper, Patricia I Dickson, Michelina Iacovino

2020-Current year OA Pubs

Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB) is a recessive genetic disorder that severely affects the brain due to a deficiency in the enzyme α-

Methylprednisolone For Heart Surgery In Infants - A Randomized, Controlled Trial, Kevin D Hill, Pirooz Eghtesady, Et Al.

2020-Current year OA Pubs

BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown.

METHODS: We conducted a multicenter, prospective, randomized, placebo-controlled, registry-based trial involving infants (<1 year of age) undergoing heart surgery with cardiopulmonary bypass at 24 sites participating in the Society of Thoracic Surgeons Congenital Heart Surgery Database. Registry data were used in the evaluation of outcomes. The infants were randomly assigned to receive prophylactic methylprednisolone (30 mg per kilogram of body weight) or placebo, which was administered into the cardiopulmonary-bypass pump-priming fluid. The primary end point was a ranked composite of death, heart transplantation, or any of 13 major complications. Patients without any of these events were assigned a ranked outcome based on postoperative length of stay. In the primary analysis, the ranked outcomes were compared between the trial groups with the use of odds ratios adjusted for prespecified risk factors. Secondary analyses included an unadjusted odds ratio, a win ratio, and safety outcomes.

RESULTS: A total of 1263 infants underwent randomization, of whom 1200 received either methylprednisolone (599 infants) or placebo (601 infants). The likelihood of a worse outcome did not differ significantly between the methylprednisolone group and the placebo group (adjusted odds ratio, 0.86; 95% confidence interval [CI], 0.71 to 1.05; P = 0.14). Secondary analyses (unadjusted for risk factors) showed an odds ratio for …

An Elf4 Hypomorphic Variant Results In Nk Cell Deficiency, Sandra Andrea Salinas, Emily M Mace, Matilde I Conte, Chun Shik Park, Yu Li, Joshua I Rosario-Sepulveda, Sanjana Mahapatra, Emily K Moore, Evelyn R Hernandez, Ivan K Chinn, Abigail E Reed, Barclay J Lee, Alexander Frumovitz, Richard A Gibbs, Jennifer E Posey, Lisa R Forbes Satter, Akaluck Thatayatikom, Eric J Allenspach, Theodore G Wensel, James R Lupski, H Daniel Lacorazza, Jordan S Orange

Faculty, Staff and Students Publications

NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD experience higher susceptibility to chronic, recurrent, and fatal viral infections. An individual with recurrent viral infections and mild hypogammaglobulinemia was identified to have an X-linked damaging variant in the transcription factor gene ELF4. The variant does not decrease expression but disrupts ELF4 protein interactions and DNA binding, reducing transcriptional activation of target genes and selectively impairing ELF4 function. Corroborating previous murine models …

Coaches Supporting Teachers Reluctant To Implement Intervention Instruction: The Role Of Reflection, Elizabeth Cutrer, Erica E. Miller

Faculty Publications

No abstract provided.

A Meta-Analysis Of Antecedent Exercise On Children’S Classroom Behaviors, Chelsea Johnson

Master's Theses

The purpose of the current study was to systematically review the literature investigating the effects of antecedent aerobic exercise on students with emotional and behavioral disorders. Eighteen studies met inclusion criteria, which included single case design studies and group studies, participant age, and an exercise intervention. Tau U was used as the procedure to calculate an effect size for A-B contrasts for single case design studies and effect size ranged from small to moderate for multiple variables such as disruptive behavior and academically engaged behavior. Hedges g was used to calculate an omnibus effect size for all single case design …