Digital Commons Network^™

Sarm1 Activation Produces Cadpr To Increase Intra-Axonal Ca++ And Promote Axon Degeneration In Pipn, Yihang Li, Maria F. Pazyra-Murphy, Daina Avizonis, Mariana De Sá Tavares Russo, Sophia Tang, Chiung-Ya Chen, Yi-Ping Hsueh, Johann S. Bergholz, Tao Jiang, Jean J. Zhao, Jian Zhu, Kwang Woo Ko, Jeffrey Milbrandt, Aaron Diantonio, Rosalind A. Segal

Open Access Publications

Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by a "dying-back" axonopathy that begins at intra-epidermal nerve terminals of sensory neurons and progresses in a retrograde fashion. Calcium dysregulation constitutes a critical event in CIPN, but it is not known how chemotherapies such as paclitaxel alter intra-axonal calcium and cause degeneration. Here, we demonstrate that paclitaxel triggers Sarm1-dependent cADPR production in distal axons, promoting intra-axonal calcium flux from both intracellular and extracellular calcium stores. Genetic or …

Perceptions Of Telemedicine And Costs Incurred By A Visit To A General Infectious Diseases Clinic: A Survey, Emily C. Evers, Stephanie A. Fritz, Graham A. Colditz, Jason P. Burnham

Open Access Publications

Background: The costs of attending in-person general infectious diseases clinics and preferences for visit type (telemedicine vs in-person) are not well known. We aimed to measure the time-related, monetary, social, and societal costs associated with travel to an in-person clinic visit and to assess patients' preferences, questions, and concerns regarding telemedicine.

Methods: Patients (≥18 years, living ≥25 miles from clinic at time of clinic visit) were recruited for this survey study from the general infectious diseases (ID) clinic at Washington University from June 2019 to February 2020. We calculated time and money potentially saved by telemedicine, as well as carbon …

What Sort Of ‘Inclusion’ Is Continuing Professional Development Promoting? An Investigation Of A National Cpd Programme For Inclusive Physical Education, Kyriaki Makopoulou, Dawn Penney, Ross Neville, Gary Thomas

Research outputs 2014 to 2021

Inclusion is positioned at the forefront of global educational reform. The study reported focused on a national Continuing Professional Development (CPD) programme for Inclusive Physical Education (IPE) in England. The research was designed to critically explore how CPD providers (i.e. tutors) variously conceptualised and practiced inclusion in the context of running a day-long CPD course for physical education teachers. Using qualitative methodology, data were collected via course observations (n = 27), informal interviews with tutors (n = 10), and a tutor questionnaire (n = 18). Findings suggest that although tutors’ theoretical interpretations of inclusion were largely consistent …

Assessing The Benefit Of Adopting Erp Technology And Practicing Green Supply Chain Management Toward Operational Performance: An Evidence From Indonesia, Ruben Wahyu Santoso, Hotlan Siagian, Zeplin Jiwa Husada Tarigan, Ferry Jie

Research outputs 2022 to 2026

The recent concern on the environmental protection and COVID-19 issue is increasingly affecting the manufacturing industry. This research assessing the benefit of adopting ERP technology and practicing green supply chain management toward operational performance in manufacturing industry. The study is essential to provide insight for the manufacturing industry regarding the consequences and benefits of practicing the green supply chain and adopting ERP technology amid the current constraints of the environmental protection issue and the COVID-19 pandemic. The study has surveyed 122 companies domiciled in Indonesia. Data collection used a questionnaire designed with a seven-point Likert scale. Questionnaire created in Google …

Rethinking The Classification Of Games And Sports In Physical Education: A Response To Changes In Sport And Participation, Justen O'Connor, Laura Alfrey, Dawn Penney

Research outputs 2022 to 2026

Background Through changing the way games are represented, classification systems have increased possibilities for teaching game forms beyond structured adult and singular official versions of popular sports. At the time of inception, the four-game form approach to classification (target, net/wall, striking/fielding, and invasion games) enabled modified, small sided conditioned games to be adapted to suit individual attributes, whilst reinforcing a core set of tactical and technical elements for transfer. With global shifts in patterns of sport participation, it is timely to review this dominant classification frame and the role it plays within physical education (PE). Purpose This paper proposes changes …

Exploring Issues Of Resilience And Technology Use For Older People - A Scoping Review Protocol, Timothy J. Smith, Khui Hung Lee, Kan Yu, Leisa Armstrong, David M. Cook

Research outputs 2022 to 2026

The aim of this scoping review is to understand the extent of issues of resilience implied by the interactions of older people with financial, social, and health related technologies. Older people aged 60+, technology use or non-use, and issues of resilience studied over the last four years (2019-2022) demarcate the scope of this review. Key exclusion criteria are older adults living in long-term care facilities, nursing homes, care homes and hospital in-patients. It also excludes studies on the perspectives of older peoples’ clinicians. The review will be carried out according to the Joanna Briggs Institute (JBI) scoping review methodology. The …

Contributing Factors Of Success For Middle School Agriculture Teachers, Sara Hughes

Murray State Theses and Dissertations

The changing dynamics of middle school agriculture education requires research into the causes for some teachers and chapters to succeed while others do not. The reasons for success may be varied and related to many different factors. The aim of this study is to determine how programs perform at high levels, what factors help them achieve success, and the role that evaluation may play in the process. The types of evaluation used for middle school agriculture teachers in Georgia will also be analyzed.

Georgia High School Counselor Perceptions Of Careers In The Agricultural Field, Meredith Arrington

Murray State Theses and Dissertations

The word “farmer” somehow still evokes that stereotypical image of an old man in overalls wearing a straw hat and holding a pitchfork. Agriculture is our nation’s largest employer, but agriculture careers still have that stigma of being backbreaking manual labor that yields a low income and is reserved for those less educated or uneducated. At the secondary education level, this type of skewed perception by school counselors can have an impact on their abilities to counsel students who are seeking college or career advice. To meet the demands of our growing population, agricultural careers have evolved to become highly …

Benedicto Sáenz 'Libera Me': Occidentalisms In Latin America Nineteenth-Century Sacred Music, Andrés R. Amado

School of Music Faculty Publications

This article uses concepts of Occidentalism and the musical analysis of a funerary responsory by nineteenth-century Guatemalan composer Benedicto Sáenz (1807-1857) to examine possible reasons why music from nineteenth-century Latin America remains relatively neglected in the region and beyond, unlike the better explored repertoires from colonial times and from the twentieth and twenty-first centuries. Based on Latin American postcolonial notions of Occidentalism as the construction of the Western Hemisphere by Western Europe in the sixteenth and seventeenth centuries, and analysis of Sáenzs responsory Libera Me within the context of changing political, social, and musical trends in nineteenth-century Guatemala, I argue …

The Effect Of Wet-Cupping Therapy (Hijama) In Modulating Autoimmune Activity Of Hashimoto’S Thyroiditis: A Pilot Controlled Study, Amal M. Obeid, Faiza A. Qari, Soad K. Aljaouni, Sawsan Rohaiem, Ahmed A. Elsayed, Maha M. Alsayyad, Ezzuddin A. Okmi

Saudi Medical Journal

Objectives: To investigate the possible effects of wet-cupping therapy (hijama) on autoimmune activity and thyroid hormonal profiles of Hashimoto’s disease (HD) patients. Methods: A prospective pilot controlled trial was carried out among adult females following HD at the Endocrinology Clinic of King Abdulaziz University Hospital, Jeddah, Saudi Arabia, from February 2014 until March 2017. A total of 13 patients (intervention group) underwent 3 hijama sessions at 3-week interval with a 6-month follow-up. Blood tests were carried out for both pre- and post-hijama, including: thyroid peroxidase antibody (TPO), thyroglobulin antibody (TG), thyroid stimulating hormone (TSH), thyroxine-4 (T4), and prolactin. Control group …

Alex Birnel, Carly Bagley

Latinx Civil Rights

Alex Birnel shares his experience organizing young voters and helping create the organization MOVE Texas. Birnel also discusses providing voter education to other young voters in the San Antonio area during his time as a college student as well as inviting the local community to participate in civic engagement outside the university campus.

Oscar Lazaro, Ashton Jeffers

Latinx Civil Rights

Oscar Lazaro shares his experience working as a fellow for the Student Voting Network as well as his observations about voting and democracy. He describes how he started his podcast as well as lessons he has learned from producing it. He also details how he addresses difficult topics with others who may disagree with him.

Charles Cotrell, Analyssa Gracía, Gabriella Parra

Latinx Civil Rights

Dr. Cotrell discusses the motivations for his activist work and the experiences he faced as a professor and community leader. He recalls cases from his time serving as an expert witness in voting rights lawsuits and notes the importance of telling stories of voter intimidation. Dr. Cotrell shares his thoughts on staying proactive in politics, gives advice to young activists, and describes how university faculty can support students in their activism. He also reflects on his personal interests and those that occupied most of his time as a professor.

Meghann Peace, Calie Brame

Latinx Civil Rights

Dr. Peace discusses the process of becoming a volunteer at RAICES and the training she received through the organization. She recounts personal stories about the poor conditions immigrants endured in detention centers. Dr. Peace also explains how RAICES helps people through the legal process of immigration

Etiem Rivera Gonzalez, Megan Angelo, Elizabeth Perez

Latinx Civil Rights

Etiem Rivera Gonzalez discussed her hardships as a DACA student and her parents’ lack of education and their traditional values. She prioritized gaining higher education by communicating with her high school professors and counselor to find financial assistance. She explains her experience working part-time and participating in school activities. Rivera Gonzalez talks about her career path and gives advice to students struggling with the immigration system.

Amir Samandi, Megan Angelo, Elizabeth Perez

Latinx Civil Rights

Amir Samandi describes his high school experiences including attending a predominately white school as a person of color. He mentions the efforts of teachers who supported him in pursuing higher education. Amir also discusses his undergraduate education at St. Mary’s University and the environment of the community. He then explains how his career led him to create a nonprofit that focuses on young students and how his personal experience connects with the organization's mission.

Natalie Marquez, Ashton Jeffers

Latinx Civil Rights

Natalie Marquez explains the work she does for Jolt Action and the ways Jolt is involved in the San Antonio Latinx community. Marquez describes how social and political issues in Texas personally affect her and her family. She also shares how to make voting a cultural norm and practice in the Latinx community.

Lloyd Van, Victoria Van Winkle

Latinx Civil Rights

As a rural doctor, Dr. Van Winkle faces many challenges to keep his practice open and operating properly. Despite the problems that have surfaced due to COVID-19, he has managed to keep his office open every single day. His love for taking care of his patients overpowers the challenges that arise.

Left Lower Limb Deep Venous Thrombosis, May-Thurner Syndrome And Endovascular Management, Khawaja B. Waheed, Hassan R. Mohammed, Khaled S. Salem, Mohamed A. Shaltout, Ali S. Alshehri, Emad F. Said, Abdulhadi S. Almubarak, Zechariah J. Arulanantham

Saudi Medical Journal

Objectives: To determine the prevalence of May-Thurner syndrome (MTS) in left lower limb deep venous thrombosis (DVT) cases and to analyze the outcome of endovascular intervention in these patients. Methods: A record-based descriptive study was carried out in Radiology Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia, including patients who underwent lower limb duplex ultrasounds between January 2015-2021. Patients with bilateral DVTs, known pelvic masses, and pelvic surgeries were excluded. All patients positive for DVTs were identified and further imaging was reviewed. Left common iliac vein compression of 50% or more on computed tomography (CT) was considered positive for …

Lessons Learned From An Enterprise-Wide Clinical Datathon, Andrew J Zimolzak, Jessica A Davila, Vamshi Punugoti, Ashok Balasubramanyam, Paul E Klotman, Laura A Petersen, Ryan H Rochat, Gloria Liao, Rory R Laubscher, Lee Leiber, Christopher I Amos

Faculty, Staff and Students Publications

In 2020, Baylor College of Medicine held a datathon to inform potential users of a new data warehouse, allow users to address clinical questions, identify warehouse capabilities and limitations, foster collaborations, and engage trainees. Senior faculty selected proposals based on feasibility and impact. Selectees worked with Information Technology for 2 months and presented findings. A survey of participants showed diverse levels of experience, high perceived value of the datathon, high rates of collaboration, and significant increases in knowledge. A datathon can promote familiarity with a new data warehouse, guide data warehouse improvement, and promote collaboration.

Management Of A Novel Autoimmune Disease, Copa Syndrome, In Pregnancy, Archana Ayyar, Rachel D Seaman, Kalpalatha Guntupalli, Mary C Tolcher

Faculty, Staff and Students Publications

BACKGROUND: COPA syndrome is a rare autoimmune disease, demonstrating an autosomal dominant inheritance pattern with variable penetration that occurs more frequently in females than males. This disease manifests in childhood as pulmonary hemorrhage, arthritis, and renal disease.

CASE: We present a case of obstetric management of a 20-year-old nulligravida patient with a diagnosis of COPA syndrome. Her case was further complicated by multiple antepartum admissions for hypoxemia and a complex psychosocial history of substance use. On her first antepartum admission, rheumatology recommended management with hydroxychloroquine, inhaled corticosteroids (budesonide), and bronchodilators (albuterol inhaler) as needed. On admission for induction of labor, …

Further Evidence That Inhibition Of Neuronal Voltage-Gated Calcium Channels Contributes To The Hypnotic Effect Of Neurosteroid Analogue, 3Β-Oh, Tamara Timic Stamenic, Francesca M Manzella, Stefan Maksimovic, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic

2020-Current year OA Pubs

We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rat pups without triggering neuronal apoptosis. Furthermore, we found that the inhibition of the Ca

Inequalities In Prevalence Of Birth By Caesarean Section In Ghana From 1998-2014, Joshua Okyere, Henry Ofori Duah, Abdul-Aziz Seidu, Bright Opoku Ahinkorah, Eugene Budu

College of Nursing Faculty Research and Publications

Background

Caesarean section (CS) is an intervention to reduce maternal and perinatal mortality, for complicated pregnancy and labour. We analysed trends in the prevalence of birth by CS in Ghana from 1998 to 2014.

Methods

Using the World Health Organization’s (WHO) Health Equity Assessment Toolkit (HEAT) software, data from the 1998-2014 Ghana Demographic and Health Surveys (GDHS) were analysed with respect of inequality in birth by CS. First, we disaggregated birth by CS by four equity stratifiers: wealth index, education, residence, and region. Second, we measured inequality through simple unweighted measures (Difference (D) and Ratio (R)) and complex weighted measures …

What Does It Mean To Be Affiliated With Care?: Delphi Consensus On The Definition Of "Unaffiliation" And "Specialist" In Sickle Cell Disease, Andrea E. Lamont, Lewis L. Hsu, Sara Jacobs, Robert Gibson, Marsha Treadwell, Yumei Chen, Richard Lottenberg, Kathleen Axelrod, Taniya Varughese, Cathy Melvin, Sharon Smith, Ifeanyi Beverly Chukwudozie, Julie Kanter, Sickle Cell Disease Implementation Consortium

2020-Current year OA Pubs

Accruing evidence reveals best practices for how to help individuals living with Sickle Cell Disease (SCD); yet, the implementation of these evidence-based practices in healthcare settings is lacking. The Sickle Cell Disease Implementation Consortium (SCDIC) is a national consortium that uses implementation science to identify and address barriers to care in SCD. The SCDIC seeks to understand how and why patients become unaffiliated from care and determine strategies to identify and connect patients to care. A challenge, however, is the lack of agreed-upon definition for what it means to be unaffiliated and what it means to be a "SCD expert …

Examining Patient Demographics Within A Physical Therapy (Pt)-Driven Proning Protocol During Covid-19 Pandemic, Christina Wood, Sidney M. Stoddard Pt, Dpt, Daniel Sawyer Pt, Dpt, Michael Pechulis Dpt, Julie M. Skrzat Pt Dpt Phd Ccs, Mark Fuse, Amanda Fox, Elizabeth A. Wetzler, Mary Loose Pt, Ryan Vetter Ms-Otr/L, Kaitlyn Musco Md, Christopher Lenivy Do, Shae Duka Bs

Department of Medicine

No abstract provided.

Development Of An Occupational Therapy Pathway For Individuals Diagnosed With Covid-19 In The Acute Care Setting, Allison Hoffman, Danielle Accordino, Lauren Reightler

Department of Medicine

No abstract provided.

An Attack On Local Authority, Richard Briffault, Kim Haddow

Faculty Scholarship

In the 2021 legislative sessions, Republican state lawmakers introduced a glut of preemption bills aimed at giving states more power over the administration of local government operations, signifying a new, deeper level of state interference into the inner workings of cities and counties. . . . Entering the 2021 legislative sessions, Republican state lawmakers used their power to respond to the events of 2020 – the pandemic, the racial justice movement, the presidential election, and what they perceived to be local government overreach (Brownstein 2021) – by introducing a surge of preemption bills aimed at appropriating the machinery of local …

Permitting Seaweed Cultivation For Carbon Sequestration In California: Barriers And Recommendations, Korey Silverman-Roati, Romany M. Webb, Michael B. Gerrard

Faculty Scholarship

Interest is growing in seaweed cultivation and sequestration as a carbon dioxide removal strategy. This white paper explores the barriers to seaweed permitting for carbon sequestration in California, including a complex, costly, and time-consuming lease and permitting process. Other states in the U.S., namely Maine and Alaska, have permitting systems designed to be more supportive of seaweed cultivation. This paper describes the legal framework for seaweed cultivation permitting in California and discusses the permitting systems in Maine and Alaska. The paper then explores possible reforms to streamline California’s permitting process, while maintaining appropriate environmental and other safeguards.

Don't Let The Digital Tail Wag The Transformation Dog: A Digital Transformation Roadmap For Corporate Counsel, Michele M. Destefano, Tellmann P. Bjarne, Daniel Wu

Articles

Due in part to the COVID-19 pandemic, enhancements in technology, as well as shifts in the macroeconomic and socioeconomic dynamics of globalization, Digital Transformation (DT) has become an enterprise-wide imperative for most multinational companies (MNCs). As a result, legal departments are being challenged to embrace enterprise DT and start their own departmental DT journeys. Despite these trends, there is little scholarship and research about how MNC legal departments are addressing the DT challenge. How are General Counsel (GCs) currently approaching DT? Is what they are doing effective and value-accretive? And importantly, how should GCs approach DT to best generate value? …

When Teachers Misgender: The Free Speech Claims Of Public School Teachers, Caroline Mala Corbin

Articles

No abstract provided.