Digital Commons Network^™

Alternative Adenosine Receptor Activation: The Netrin-Adora2b Link, Xiaoyi Yuan, Tingting Mills, Marie-Francoise Doursout, Scott E Evans, Marcos F Vidal Melo, Holger K Eltzschig

Faculty, Staff and Student Publications

During hypoxia or inflammation, extracellular adenosine levels are elevated. Studies using pharmacologic approaches or genetic animal models pertinent to extracellular adenosine signaling implicate this pathway in attenuating hypoxia-associated inflammation. There are four distinct adenosine receptors. Of these, it is not surprising that the Adora2b adenosine receptor functions as an endogenous feedback loop to control hypoxia-associated inflammation. First, Adora2b activation requires higher adenosine concentrations compared to other adenosine receptors, similar to those achieved during hypoxic inflammation. Second, Adora2b is transcriptionally induced during hypoxia or inflammation by hypoxia-inducible transcription factor HIF1A. Studies seeking an alternative adenosine receptor activation mechanism have linked netrin-1 …

Critical Analysis Of Laboratory Requisition Forms Received In A Cytopathology Laboratory Of A Tertiary Care Centre: An Audit And Review Of Literature, Shivali Sehgal, Sujata Jetley, Zeeba S Jairajpuri, Sabina Khan

Faculty, Staff and Student Publications

BACKGROUND: A laboratory requisition form (LRF) is the main communication link between the laboratories and the clinicians. In a cytopathology laboratory, incomplete forms with inadequate information significantly impact the quality of the results and waste precious time of the lab.

AIMS: The aim of this study was to audit the LRFs for adequacy of demographic and clinical data and to analyze the reasons for the same.

SETTINGS AND DESIGN: A retrospective study was conducted in the cytopathology laboratory of a tertiary care center.

MATERIALS AND METHODS: All the original LRFs received for Pap smears and FNACs of 1-month duration were …

Single-Cell Rna Sequencing Reveals Intratumoral Heterogeneity And Potential Mechanisms Of Malignant Progression In Prostate Cancer With Perineural Invasion, Bao Zhang, Shenghan Wang, Zhichao Fu, Qiang Gao, Lin Yang, Zhentao Lei, Yuqiang Shi, Kai Le, Jie Xiong, Siyao Liu, Jiali Zhang, Junyan Su, Jing Chen, Mengyuan Liu, Beifang Niu

Faculty, Staff and Student Publications

Background: Prostate cancer (PCa) is the second most common cancer among men worldwide. Perineural invasion (PNI) was a prominent characteristic of PCa, which was recognized as a key factor in promoting PCa progression. As a complex and heterogeneous disease, its true condition is difficult to explain thoroughly with conventional bulk RNA sequencing. Thus, an improved understanding of PNI-PCa progression at the single-cell level is needed.

Methods: In this study, we performed scRNAseq on tumor tissues of three PNI-PCa patients. Principal component analysis (PCA) and Uniform manifold approximation and projection (UMAP) were used to reduce dimensionality and visualize the cellular composition …

Circadian Stabilization Loop: The Regulatory Hub And Therapeutic Target Promoting Circadian Resilience And Physiological Health, Eunju Kim, Seung-Hee Yoo, Zheng Chen

Faculty, Staff and Student Publications

The circadian clock is a fundamental biological mechanism that orchestrates essential cellular and physiological processes to optimize fitness and health. The basic functional unit is the cell-autonomous oscillator, consisting of intersecting negative feedback loops. Whereas the core loop is primarily responsible for rhythm generation, auxiliary loops, most notably the secondary or stabilization loop, play pivotal roles to confer temporal precision and molecular robustness. The stabilization loop contains opposing nuclear receptor subfamilies REV-ERBs and retinoic acid receptor-related orphan receptors (RORs), competing to modulate rhythmic expression of the basic helix-loop-helix ARNT like 1 (Bmal1) genes in the core loop as …

Impact On Clinical Outcomes From Transcatheter Closure Of The Fontan Fenestration: A Systematic Review And Meta-Analysis, Christopher E Greenleaf, Zhia Ning Lim, Wen Li, Damien J Lapar, Jorge D Salazar, Antonio F Corno

Faculty, Staff and Student Publications

BACKGROUND: Meta-analysis of the impact on clinical outcome from transcatheter closure of Fontan fenestration.

METHODS: Cochrane, Embase, MEDLINE, and Open-Gray were searched. Parameters such as changes in oxygen saturation, cavo-pulmonary pressure, maximum heart rate during exercise, exercise duration, and oxygen saturation after fenestration closure were pooled and statistical analysis performed.

RESULTS: Among 922 publications, 12 retrospective observational studies were included. The included studies involved 610 patients, of which 552 patients (90.5%) had a fenestration. Of those patients, 505 patients (91.5%) underwent attempt at trans-catheter closure. When it could be estimated, the pooled overall mean age at trans-catheter fenestration closure was …

Real-World Evidence Of An Emollient Device For Atopic And Contact Dermatitis In Pediatric To Adult Patients – Data From A Post-Marketing Surveillance, Adelaide Ann Hebert

Faculty, Staff and Student Publications

PURPOSE: Atopic and contact dermatitis have been attributed to skin barrier abnormalities, immune system dysfunction and inflammation leading to pruritus. As these factors may involve oxidative stress, emollient devices containing antioxidants furfuryl palmitate and tocopherol may help reduce itching and inflammation. In this study, a post-marketing questionnaire was carried out of 40 users of a novel emollient device containing furfuryl palmitate and tocopherol (Relizema™ cream), who purchased it from a pharmacy or health-care professional to ascertain the emollient device's action on itching, flushing and moisturizing.

PATIENTS AND METHODS: The post-marketing questionnaire, administered by trained pharmacy and health-care staff, collected data …

Comparative Analysis Of Gene Expression Patterns For Oral Epithelial Cell Functions In Periodontitis, Octavio A Gonzalez, Sreenatha Kirakodu, Linh M Nguyen, Luis Orraca, Michael J Novak, Janis Gonzalez-Martinez, Jeffrey L Ebersole

Faculty, Staff and Student Publications

The structure and function of epithelial cells are critical for the construction and maintenance of intact epithelial surfaces throughout the body. Beyond the mechanical barrier functions, epithelial cells have been identified as active participants in providing warning signals to the host immune and inflammatory cells and in communicating various detailed information on the noxious challenge to help drive specificity in the characteristics of the host response related to health or pathologic inflammation. Rhesus monkeys were used in these studies to evaluate the gingival transcriptome for naturally occurring disease samples (GeneChip® Rhesus Macaque Genome Array) or for ligature-induced disease (GeneChip® Rhesus …

Rekindling Yellowstone's Early History: 150 Years Later, Sam Kalen

Wyoming Law Review

No abstract provided.

A Price Tag On Adventure: Disorderly Conduct Liability For Search And Rescue In America's National Parks, Jenna Vonhofe

Wyoming Law Review

No abstract provided.

A Proposed Grief Support Group Intervention For College Students At A University Counseling Center, Kyle Cacoyannis

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The current paper draws upon previous literature, along with the author's experience facilitating grief support groups to introduce a proposed grief support group intervention that could be implemented with college students at university counseling centers in the United States and potentially abroad. The author discusses literature on grief, grief support groups at university counseling centers and in other settings, and presenting problems related to grief among college students and young adults which help inform the design of the proposed intervention. The group intervention design is outlined in detail in the Appendix section, however the Method section gives a brief synopsis …

From Me To We: A Phenomenological Inquiry Into Group Beingness, Stacey K. Guenther

Antioch University Dissertations & Theses

To be human is to be a member of myriad groups. The universality of groups in our lives poses an important area of study for social scientists investigating human flourishing. Additionally, inquiring into the evolutionary potential of groups may begin to inform new ways of addressing the intractable issues we face as a human species. While most empirical studies of groups focus on group performance, or group doingness, this study explored group beingness and the experience of manifesting deep union and oneness, which is an intersubjective phenomenon that has been called coherence. Intersubjective coherence is often written about from a …

Theater And Peacebuilding In Post-Conflict Settings: Participants’ Experiences In The Morning Star Theater Program In South Sudan, Shiphrah Mutungi Akandiinda

Antioch University Dissertations & Theses

This dissertation explores the role of theater for peacebuilding in post-conflict settings through the analysis of experiences of participants in the Morning Star Forum Theater for Peacebuilding in South Sudan. Arts-based activities, including theater, have increasingly gained momentum as viable interventions for peacebuilding in post-conflict zones. Much of the existent research fails to capture the experiences of the theater participants themselves. Using narrative inquiry, this study interviewed 12 community members who participated in the Morning Star Forum Theater event. In particular, this study focused on how experiences of Morning Star Theater events impacted interpersonal growth and relationship-building, thus positively impacting …

Afroam: A Virtual Film Production Group, Bill Taylor Jr.

Antioch University Dissertations & Theses

Because of the gatekeeping practices of the Hollywood film industry, and the high cost of both filmmaking and distribution in general, Afro-American filmmakers have struggled to produce films with “global reach.” This study visits the possibility of Afro-American filmmakers using alternative technologies and infrastructures to produce high-quality films, thereby bypassing the high cost and exclusionary practices of Hollywood studios. Using new 21st-century digital technology, this study involved the creation of a small geographically dispersed virtual film production team. The study’s foundational framework was a constructivist qualitative research paradigm, using Action Research, and supported by 24 months of triangulated data from …

Dancing Between Two Worlds: Training Experiences Of Dual Credentialed Counselors, Lisa Rudduck

Antioch University Dissertations & Theses

Several challenges exist in the implementation of integrated care given that SUD/Addiction treatment has historically been segregated from the broader health care system (Office of the Surgeon General, 2016). One expression of the gap that persists is that for counselors who want to administer SUD/Addiction and mental health counseling, or co-occurring services, in Washington State they are required to satisfy state requirements for two separate credentials. The purpose of this study was to conduct an in-depth exploration into the training experiences of Dual Credentialed Counselors (DCCs) in Washington State where two separate credentials are required to administer co-occurring counseling. In …

Exploring The Leadership-As-Practice Of Middle Managers Engaged In Organizational Changes In An Asia Pacific Multinational Setting, Eric Kung

Antioch University Dissertations & Theses

There has been a great need for leadership studies on middle management, particularly in the Asia Pacific context. This study explored the leadership practices of middle managers engaged in leading organizational changes of multinational corporations (MNCs), within the Asia Pacific context. Organization ethnography was used as the research method. The ethnographer observed and analyzed the actual practice of middle managers of a multinational manufacturing company located in China for six months. The findings showed that middle managers played significant roles in communication and execution in leading organizational changes. The study also showed that change management could be a dynamic process …

Reframing Leadership Narratives Through The African American Lens, Marion Missy Mcgee

Antioch University Dissertations & Theses

Reframing Leadership Narratives through the African American Lens explores the context-rich experiences of Black Museum executives to challenge dominant cultural perspectives of what constitutes a leader. Using critical narrative discourse analysis, this research foregrounds under-told narratives and reveals the leadership practices used to proliferate Black Museums to contrast the lack of racially diverse perspectives in the pedagogy of leadership studies. This was accomplished by investigating the origin stories of African American executives using organizational leadership and social movement theories as analytical lenses for making sense of leaders’ tactics and strategies. Commentary from Black Museum leaders were interspersed with sentiments of …

Thriving Through Experience: A Phenomenological Inquiry Of Community-Engaged Learning, Katharine O'Connor

Antioch University Dissertations & Theses

Community-engaged learning is a high impact educational practice that has been proven to aid in retention rates and overall student success (Kuh, 2008). As an educator, I have had many students tell me that their community-engaged learning experiences helped them develop leadership skills. And while there have been many quantitative studies considering the grade point averages and retention rates, there is a need for research that focuses on the lived experience of people who participate in community-engaged learning. This dissertation focused on young adult women who have emerged as leaders through their community-engaged learning experiences. Through the use of interpretive …

A Journey To Finding Space In The Tension: Experience Of Instructors' Relationship With Religion And Spirituality In Doctoral Psychology Programs, Samantha Mcgee

Antioch University Dissertations & Theses

Religion and spirituality, when viewed through a holistic lens, can reflect important aspects of a person’s identity. It can be a source of well-being and also struggle. The fields of religion, spirituality and psychology have had a history of being polarized, with some efforts to integrate the two fields. Tensions exist at multiple ecological levels around the topic of religion and spirituality, which can make it easier to avoid discussing it in classrooms and therapy rooms. It is important to address and create room for discussion of experiences around religion and spirituality in classrooms that are training psychologists so they …

Integrating Interpersonal Neurobiology In Healthcare Leadership And Organizations, Lynn Redenbach

Antioch University Dissertations & Theses

Interpersonal Neurobiology (IPNB) is an interdisciplinary, science-based field that seeks to understand human reality including the nature of mind, brain, and relationships. IPNB has been used extensively by mental health practitioners as well as child development and parenting experts. While practitioners and scholars have described ways that IPNB can be used in leadership and organizations, there has been no systematic inquiry into the practical and phenomenological experience of this application. IPNB offers an alternative to dominant models of care and leading in healthcare settings and fields, which are characterized by disconnection, objectification, and separation. It offers a relationally centered approach …

Traditional Healing In Psychology On The Caribbean Island Of Montserrat, West Indies, Yvette Adelcia Cabey

Antioch University Dissertations & Theses

In Montserrat, traditional healing medicines consist of herbal treatments and customary therapeutic methods such as ritual practices and herbal teas also known as “Bush and Weed” (Duberry, 1973, p.1). The purpose of this study is to discuss herbs known as “Bush,” in Montserrat, and how they benefit psychological wellbeing among the communities in Montserrat. A subsequent intention of this study is to address how an understanding of Montserratian Traditional Healing remedies can be beneficial to Western Psychological practice and enhance the efficacy for psychological healing. The gap in the literature indicates that few studies are examining mental health methods in …

Entitlement, Psychological Vulnerability, And Criminality: An Expansion On Grubbs And Exline's (2016) Model, Allison Dart

Antioch University Dissertations & Theses

The current study examines the predictive relationships among Entitlement, criminal thinking, and psychological vulnerability. Eighty male incarcerated individuals participated in this research and four measures were administered to each participant: the Adverse Childhood Experiences Questionnaire (ACEs), the Texas Christian University Criminal Thinking Scale (TCU-CTS), the Woodcock Johnson-IV Cognitive Brief Intellectual Abilities scale (WJ-IV COG BIA), and the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF). Results yielded the following findings: Behavioral/Externalizing Dysfunction was the best predictor of Entitlement. Behavioral/Externalizing Dysfunction and Thought Dysfunction were the best predictors of each of the other aspects of criminogenic thinking. Emotional/Internalizing Dysfunction did not reliably …

Youth Leadership Through Adventure: Alums' Perspectives On The Experience Of Leadership, Raynalde Schagen

Antioch University Dissertations & Theses

In this study, I examined the perspectives that emerging adult alums of a program called Youth Leadership Through Adventure (YLTA) have of their adolescent experiences of being a leader. Eight YLTA alums engaged in semi-structured interviews focusing on the research questions: What are the lived experiences of leadership in emerging adult alums of YLTA? What factors of their adolescent involvement were most influential in their emerging adult lives? As a youth development program, YLTA is supported by Adapt and the North Country Health Consortium (NCHC), two nonprofit organizations devoted to improving health conditions and habits of individuals residing in the …

A Genuine Artifice, A Specific Vagueness: Psychotherapy, Performance, And The Practitioner, Chris M. Defossez

Antioch University Dissertations & Theses

The following is a literature review and research project aimed at examining the performative choices psychologists make when interacting with their patients. The goal for this research is to begin to understand the “essence” of a psychologist‘s experience as they present themselves in their work. Drawing from published literature on the therapeutic alliance, social constructionism, postmodern feminism, art, and aesthetics, the author argues that the therapeutic frame taken by a particular therapist can be understood as a performative act. This author examines the implications of this idea and what can be learned from conceptualizing the therapeutic alliance through a performative …

Therapist Self-Reported Attachment Organization And Countertransference Responses To Psychotherapy Clients, Morgan Janay Pell

Antioch University Dissertations & Theses

Therapists experience thoughts, feelings, and behaviors in response to their clients, which are sometimes referred to as countertransference. Such responses may be influenced by the therapist’s personal history, including the quality of their attachment experiences. Research has demonstrated that adult attachment organizations influence a person’s cognitive, behavioral, and affective responses toward close others, thus providing a useful framework for understanding some countertransference experiences of therapists. This quantitative study sought to add to the existing literature by examining the relationship between therapist self-reported attachment organization and countertransference responses to clients. Seventy-three therapists participated in this study, including licensed psychologists, doctorate-level psychologists, …

Narrative Enhancement And Cognitive Therapy With Correctional Psychiatric Patients: A Pilot Study, Richelene Cesar

Antioch University Dissertations & Theses

Narrative Enhancement and Cognitive Therapy (NECT) is a manualized, group-based intervention that was originally developed to treat self-stigma among individuals who present with severe and persistent mental illnesses (SPMIs; Roe, Lysaker, & Yanos, 2013). NECT has been shown to effectively reduce these individuals’ experience of self-stigma, and diminish its negative effects on their hope, self-esteem, self-efficacy, and quality of life (Yanos, Roe, & Lysaker, 2011). Supportive literature is scarce regarding NECT’s efficacy with people who have multiple stigmatized identities. For the purposes of this pilot study, NECT was implemented with a correctional psychiatric population. Research supports this population is doubly, …

Life Stories Of Older Chinese Immigrant Women In The U.S., Lijun Li

Antioch University Dissertations & Theses

This study is an effort to turn to older Chinese immigrant women aged 60 and above, one of the most marginalized groups in American society, to recognize their humanity and rediscover the unseen and unheard. It asks what we can learn from their life stories, particularly from the ways in which each experience(d) being a woman in different societal systems. Using in-depth life story interviews supplemented with secondary sources of information, this study crafts four women’s stories that are first read and interpreted individually to capture the whole person in context, and then are looked at thematically. Nine themes are …

Let's Talk About Sex: The Importance Of Sexuality Training In Doctoral Psychology Programs, Leja S. Wright

Antioch University Dissertations & Theses

Sex is an integral part of human nature and identity (Sanabria & Murray, 2018), yet many clinical psychology programs may not offer adequate sexuality training. This study explored clients’ needs for support surrounding sexuality, clinical competence in human sexuality, and the availability of human sexuality training in doctoral psychology programs across the United States. In an effort to create a large sample size, I randomly chose 25 doctoral psychology programs to examine the nature of their sexuality trainings or sex education. Only two of these programs offered classes or trainings, though neither of the programs required the courses for program …

Women Seeking The Public School Superintendency: Navigating The Gendered And Racialized-Gendered Job Search, Rachel M. Roberts

Antioch University Dissertations & Theses

I have been an educator for my entire career. First, as a teacher and over the last decade as a school administrator. During my tenure, I have continually noticed the underrepresentation of women in the highest office: the school superintendent. This has vexed me over the years, and as a scholar practitioner in leadership and change, I have devoted my research to unearthing the inequalities and disproportional realities that exist within high-profile leadership, particularly the public school superintendency. Utilizing a grounded theory approach, this dissertation sought to better understand what happens at the micro-level, especially during and after the superintendent …

Love And Learn: Creating Space For Authentic Caring In Family Child Care, Katherine Kelly Hart Meehan

Antioch University Dissertations & Theses

Children benefit from engagement in early education and care (ECE) programs that support their learning and development while also providing a point of connection to critical resources for their families. For children from economically disadvantaged families, the lack of access to high-quality ECE results in a persistent achievement and opportunity gap (García & Weiss, 2015). A significant portion of ECE occurs in home-based early learning environments, also known as family child care (FCC) programs, which play a critical role in supporting children from low-income and immigrant families (Layzer et al., 2007; Porter et al., 2010). Unfortunately, this sector of ECE …

Seeking Treatment For Ptsd: The Post 9/11 Service Member's Experience, Stephanie A. Bowser

Antioch University Dissertations & Theses

Posttraumatic-stress disorder (PTSD) remains one of the most pervasive health conditions to affect the 2.7 million United States service members deployed to Iraq and Afghanistan since 2001. Untreated and/or inadequately treated PTSD can further lead to an array of health risks including anxiety, depression, substance abuse, social and occupational impairments, poorer quality of physical health, decreased overall perception of quality of life, and increase the risk of suicide. Considering these risks, the Department of Veterans Affairs (VA) and Department of Defense (DoD) created the VA/DOD Clinical Practice Guidelines (CPGs) for the Management of PTSD and Acute Stress Reaction (ASR), highlighting …