Digital Commons Network^™

Efficacy And Safety Of Pacritinib Vs Placebo For Patients With Severe Covid-19: A Phase 2 Randomized Clinical Trial, John Cafardi, Carole Miller, Howard Terebelo, Chad Tewell, Sadia Benzaquen, David Park, Pamela Egan, Daniel Lebovic, Kristen Pettit, Eric Whitman, Douglas Tremblay, Jonathan Feld, Sarah Buckley, Karisse Roman-Torres, Jennifer Smith, Adam Craig, John Mascarenhas

Einstein Health Papers

IMPORTANCE: The morbidity and mortality associated with COVID-19 remain high despite advances in standard of care therapy, and the role of anti-inflammatory agents that inhibit the interleukin 6/JAK2 pathway is still being elucidated.

OBJECTIVE: To evaluate the efficacy and safety of the oral JAK2/IRAK1 inhibitor pacritinib vs placebo in the treatment of adults with severe COVID-19.

DESIGN, SETTING, AND PARTICIPANTS: This phase 2, double-blind, placebo-controlled, randomized clinical trial enrolled hospitalized adult patients with severe COVID-19 at 21 centers across the US between June 2020 and February 2021, with approximately 1.5 months of safety follow-up per patient. Data analysis was performed …

Exposure Of Egyptian Rousette Bats (Rousettus Aegyptiacus) And A Little Free-Tailed Bat (Chaerephon Pumilus) To Alphaviruses In Uganda, Rebekah C. Kading, Erin M. Borland, Eric C. Mossel, Teddy Nakayiki, Betty Nalikka, Jeremy P. Ledermann, Mary B. Crabtree, Nicholas A. Panella, Luke Nyakarahuka, Amy T. Gilbert, Julian C. Kerbis-Peterhans, Jonathan S. Towner, Brian R. Amman, Tara K. Sealy, Barry R. Miller, Julius J. Lutwama, Robert M. Kityo, Ann M. Powers

United States Department of Agriculture Wildlife Services: Staff Publications

The reservoir for zoonotic o’nyong-nyong virus (ONNV) has remained unknown since this virus was first recognized in Uganda in 1959. Building on existing evidence for mosquito bloodfeeding on various frugivorous bat species in Uganda, and seroprevalence for arboviruses among bats in Uganda, we sought to assess if serum samples collected from bats in Uganda demonstrated evidence of exposure to ONNV or the closely related zoonotic chikungunya virus (CHIKV). In total, 652 serum samples collected from six bat species were tested by plaque reduction neutralization test (PRNT) for neutralizing antibodies against ONNV and CHIKV. Forty out of 303 (13.2%) Egyptian rousettes …

Effects Of Antecedent Precipitation Amount And Covid-19 Lockdown On Water Quality Along An Urban Gradient, Daniel Ramirez, Heejun Chang, Katherine Gelsey

Geography Faculty Publications and Presentations

Water quality is affected by multiple spatial and temporal factors, including the surrounding land characteristics, human activities, and antecedent precipitation amounts. However, identifying the relationships between water quality and spatially and temporally varying environmental variables with a machine learning technique in a heterogeneous urban landscape has been understudied. We explore how seasonal and variable precipitation amounts and other small-scale landscape variables affect E. coli, total suspended solids (TSS), nitrogen-nitrate, orthophosphate, lead, and zinc concentrations in Portland, Oregon, USA. Mann–Whitney tests were used to detect differences in water quality between seasons and COVID-19 periods. Spearman’s rank correlation analysis was used to …

Apocalypse Eternal: "The Road" And "Parable" Series As Pilgrimage, Caleb Gurule

Senior Honors Theses

Octavia Butler’s Parable of the Sower and Cormac McCarthy’s The Road represent two different views on how humans create meaning in a postapocalyptic world. The authors’ writings utilize the critical dystopia genre, in which the protagonists’ surroundings are bleak but the possibility of redemption remains. As Butler’s Lauren Olamina travels from her burned-down home to a place where she can begin a new community with her religion, Earthseed, as the foundational structure, she brings together a group of diverse and useful people who aid her in her pilgrimage to a better place. The protagonist’s identity as a mentally impaired black …

Incantation Of The Nine Words, Donny Limber De Atocha Brito May

Maya America: Journal of Essays, Commentary, and Analysis

Incantation of the Nine Words is an original poem by Donny Limber Brito May. This poem in Yucatec Maya and in Spanish also appears in this issue of Maya America.

Connecting Depaul

DePaul Magazine

DePaul President Robert L. Manuel, inaugurated as the university's 13th president in fall 2022, inspires and invigorates the DePaul community, creating a renewed sense of mission.

Federated Learning Enables Big Data For Rare Cancer Boundary Detection, Sarthak Pati, Ujjwal Baid, Brandon Edwards, Micah Sheller, Shih-Han Wang, G. Anthony Reina, Patrick Foley, Alexey Gruzdev, Deepthi Karkada, Christos Davatzikos, Chiharu Sako, Satyam Ghodasara, Michel Bilello, Suyash Mohan, Philipp Vollmuth, Gianluca Brugnara, Chandrakanth J. Preetha, Felix Sahm, Klaus Maier-Hein, Maximilian Zenk, Martin Bendszus, Wolfgang Wick, Evan Calabrese, Jeffrey Rudie, Javier Villanueva-Meyer, Soonmee Cha, Madhura Ingalhalikar, Manali Jadhav, Umang Pandey, Jitender Saini, John Garrett, Matthew Larson, Robert Jeraj, Stuart Currie, Russell Frood, Kavi Fatania, Raymond Y. Huang, Ken Chang, Carmen Balaña, Jaume Capellades, Josep Puig, Johannes Trenkler, Josef Pichler, Georg Necker, Andreas Haunschmidt, Stephan Meckel, Gaurav Shukla, Spencer Liem, Gregory S Alexander, Joseph Lombardo, Joshua D. Palmer, Adam E. Flanders, Adam P. Dicker, Haris I. Sair, Craig K. Jones, Archana Venkataraman, Meirui Jiang, Tiffany Y. So, Cheng Chen, Pheng Ann Heng, Qi Dou, Michal Kozubek, Filip Lux, Jan Michálek, Petr Matula, Miloš Keřkovský, Tereza Kopřivová, Marek Dostál, Václav Vybíhal, Michael A. Vogelbaum, J. Ross Mitchell, Joaquim Farinhas, Joseph A. Maldjian, Chandan Ganesh Bangalore Yogananda, Marco C. Pinho, Divya Reddy, James Holcomb, Benjamin C. Wagner, Benjamin M. Ellingson, Timothy F. Cloughesy, Catalina Raymond, Talia Oughourlian, Akifumi Hagiwara, Chencai Wang, Minh-Son To, Sargam Bhardwaj, Chee Chong, Marc Agzarian, Alexandre Xavier Falcão, Samuel B. Martins, Bernardo C. A. Teixeira, Flávia Sprenger, David Menotti, Diego R. Lucio, Pamela Lamontagne, Daniel Marcus, Benedikt Wiestler, Florian Kofler, Ivan Ezhov, Marie Metz, Rajan Jain, Matthew Lee, Yvonne W. Lui, Richard Mckinley, Johannes Slotboom, Piotr Radojewski, Raphael Meier, Roland Wiest, Derrick Murcia, Eric Fu, Rourke Haas, John Thompson, David Ryan Ormond, Chaitra Badve, Andrew E. Sloan, Vachan Vadmal, Kristin Waite, Rivka R. Colen, Linmin Pei, Murat Ak, Ashok Srinivasan, J. Rajiv Bapuraj, Arvind Rao, Nicholas Wang, Ota Yoshiaki, Toshio Moritani, Sevcan Turk, Joonsang Lee, Snehal Prabhudesai, Fanny Morón, Jacob Mandel, Konstantinos Kamnitsas, Ben Glocker, Luke V. M. Dixon, Matthew Williams, Peter Zampakis, Vasileios Panagiotopoulos, Panagiotis Tsiganos, Sotiris Alexiou, Ilias Haliassos, Evangelia I Zacharaki, Konstantinos Moustakas, Christina Kalogeropoulou, Dimitrios M. Kardamakis, Yoon Seong Choi, Seung-Koo Lee, Jong Hee Chang, Sung Soo Ahn, Bing Luo, Laila Poisson, Ning Wen, Pallavi Tiwari, Ruchika Verma, Rohan Bareja, Ipsa Yadav, Jonathan Chen, Neeraj Kumar, Marion Smits, Sebastian R. Van Der Voort, Ahmed Alafandi, Fatih Incekara, Maarten M. J. Wijnenga, Georgios Kapsas, Renske Gahrmann, Joost W Schouten, Hendrikus J. Dubbink, Arnaud J. P. E. Vincent, Martin J. Van Den Bent, Pim J. French, Stefan Klein, Yading Yuan, Sonam Sharma, Tzu-Chi Tseng, Saba Adabi, Simone P. Niclou, Olivier Keunen, Ann-Christin Hau, Martin Vallières, David Fortin, Martin Lepage, Bennett Landman, Karthik Ramadass, Kaiwen Xu, Silky Chotai, Lola B. Chambless, Akshitkumar Mistry, Reid C. Thompson, Yuriy Gusev, Krithika Bhuvaneshwar, Anousheh Sayah, Camelia Bencheqroun, Anas Belouali, Subha Madhavan, Thomas C. Booth, Alysha Chelliah, Marc Modat, Haris Shuaib, Carmen Dragos, Aly Abayazeed, Kenneth Kolodziej, Michael Hill, Ahmed Abbassy, Shady Gamal, Mahmoud Mekhaimar, Mohamed Qayati, Mauricio Reyes, Ji Eun Park, Jihye Yun, Ho Sung Kim, Abhishek Mahajan, Mark Muzi, Sean Benson, Regina G. H. Beets-Tan, Jonas Teuwen, Alejandro Herrera-Trujillo, Maria Trujillo, William Escobar, Ana Abello, Jose Bernal, Jhon Gómez, Joseph Choi, Stephen Baek, Yusung Kim, Heba Ismael, Bryan Allen, John M. Buatti, Aikaterini Kotrotsou, Hongwei Li, Tobias Weiss, Michael Weller, Andrea Bink, Bertrand Pouymayou, Hassan F. Shaykh, Joel Saltz, Prateek Prasanna, Sampurna Shrestha, Kartik M. Mani, David Payne, Tahsin Kurc, Enrique Pelaez, Heydy Franco-Maldonado, Francis Loayza, Sebastian Quevedo, Pamela Guevara, Esteban Torche, Cristobal Mendoza, Franco Vera, Elvis Ríos, Eduardo López, Sergio A. Velastin, Godwin Ogbole, Mayowa Soneye, Dotun Oyekunle, Olubunmi Odafe-Oyibotha, Babatunde Osobu, Mustapha Shu'aibu, Adeleye Dorcas, Farouk Dako, Amber L. Simpson, Mohammad Hamghalam, Jacob J. Peoples, Ricky Hu, Anh Tran, Danielle Cutler, Fabio Y. Moraes, Michael A. Boss, James Gimpel, Deepak Kattil Veettil, Kendall Schmidt, Brian Bialecki, Sailaja Marella, Cynthia Price, Lisa Cimino, Charles Apgar, Prashant Shah, Bjoern Menze, Jill S. Barnholtz-Sloan, Jason Martin, Spyridon Bakas

Department of Radiation Oncology Faculty Papers

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically …

Atrial Fibrillation In Aging: Mechanisms And Potential Therapeutics, Mengmeng Chang

USF Tampa Graduate Theses and Dissertations

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias seen in the clinics, and currently available antiarrhythmic pharmacotherapies in AF are not very effective. Although AF has been recognized as an aging-mediated disease, our understanding of the electrophysiological pathways that link aging and AF remain incomplete, which limits breakthroughs in the development of novel antiarrhythmic treatments for this disease. Studies have shown that aging increases the generation of reactive oxygen species (ROS) in the heart, and high levels of ROS have been associated with development of AF in animals and patients. Additionally, in some forms of AF, the …

Effects Of Castor Oil Nanoemulsion Extracted By Hexane On The Fourth Larval Stage Of Culex Quinquefsciatus From Al Hawizeh Marsh/Iraq, And Non- Targeted Organism, Alla Abd Al Hassan Al Hilfy, Soolaf A. Kathiar, Hazim Idan Al Shammari

Baghdad Science Journal

The current study aims to show the importance of plant products as mosquitocides against Culex quinquefasciatus. Castor oil Nanoemulsions were subedit in various ratios including castor oil, ethanol, tween 80, and deionized water by using ultrasonication. Thermodynamic, centrifugation, PH, assay which improved that the formula of 10 ml of castor oil, ethanol 5ml, tween 80 (14 ml) and deionized water 71ml was more stable than other formulas. The stable formula of castor oil nanoemulsion was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Nanoemulsion droplets were spherical in shape and were found to have a Z-average diameter …

Preliminary Phytochemical Analysis And Invitro Antiplasmodial Activity Of Terminalia Mantaly Against Plasmodium Falciparum, Bello Muhammad Usman, Daniel Dan-Inna Attah, Danladi Yusuf Kanya

Folia Medica Indonesiana

Highlights: • Malaria is prevalent in many populations of communities despite preventive measures. • The experimental was screened for bioactive components which could be the reason for the antimalarial effect and the plant shows dose dependent antimalarial activity. Abstract : Malaria has been one of the world's worst killer diseases throughout recorded human history. Despite attempts to eradicate the disease, it remains a global burden. This could be a result of parasite resistance to current therapy. However, this research aimed at evaluating the in vitro antimalarial activity of ethanolic extracts of Terminalia mantaly on Plasmodium falciparum. The plant extracts were …

Chondroregenerative Potential Of Platelet-Rich Fibrin (Prf)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously, Putu Ardhy Parama Widyatmika, Muhammad Sjaifuddin Noer, Magda Rosalina Hutagalung

Folia Medica Indonesiana

Highlights: • This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage. • The formation of newly-regenerated chondrocyte, the thickness of type II collagen, and the rate of cartilage resorption following the subcutaneous implantation were assessed. • BCPRF is highly biocompatible and can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material. Abstract: The invention of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged due to high morbidity of the donor site related to autologous harvesting process. This research attempted an invention of alternative implant …

Healing Of Radiation Dermatitis With Ozonated Aloe Vera Oil By Increasing Pdgf And Epidermal Thickness In Sprague-Dawley Rats, Widoasti Putri Utami, Yan Wisnu Prajoko, Christina H.N. Prihharsanti, Udadi Sadhana, Neni Susilaningsih, Maryam Restiwijaya, Muhammad Nur

Folia Medica Indonesiana

Highlights: • This study demonstrated the effect of ozonated Aloe vera oil in the healing of radiation dermatitis wound. • Groups that received no treatment was compared with groups that received treatment using 2.5% hydrocortisone ointment and ozonated Aloe vera. • Ozonated Aloe vera oil improves the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness. Abstract : The long-term use of corticosteroids as a standard treatment for skin disorders, such as radiation dermatitis, can cause many side effects. Alternatively, ozonated Aloe vera oil may replace corticosteroids due to its fewer side effects and benefits in wound …

Selective Vulnerability Of The Intermediate Retinal Capillary Plexus Precedes Retinal Ganglion Cell Loss In Ocular Hypertension, Priyamvada M Pitale, Guofu Shen, Rohini R Sigireddi, Maria Polo-Prieto, Yong H Park, Solomon E Gibson, Peter D Westenskow, Roomasa Channa, Benjamin J Frankfort

Faculty, Staff and Students Publications

Introduction: Glaucoma, a disease of retinal ganglion cell (RGC) injury and potentially devastating vision loss, is associated with both ocular hypertension (OHT) and reduced ocular blood flow. However, the relationship between OHT and retinal capillary architecture is not well understood. In this project, we studied microvasculature damage in mice exposed to mild levels of induced OHT.

Methods: Mild OHT was induced with the microbead model for 2 weeks. At this time point, some retinas were immunostained with CD31 (endothelium), Collagen IV (basement membrane), and RBPMS (RGCs) for z-stack confocal microscopy. We processed these confocal images to distinguish the three retinal …

Activity Disruption Causes Degeneration Of Entorhinal Neurons In A Mouse Model Of Alzheimer’S Circuit Dysfunction, Rong Zhao, Stacy D Grunke, Caleb A Wood, Gabriella A Perez, Melissa Comstock, Ming-Hua Li, Anand K Singh, Kyung-Won Park, Joanna L Jankowsky

Faculty, Staff and Students Publications

Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Here, we show that entorhinal cortex layer 2 (EC2) neurons are unusually vulnerable to prolonged neuronal inactivity compared with neighboring regions of the temporal lobe, and that reelin + stellate cells connecting EC with the hippocampus are preferentially susceptible within the EC2 population. We demonstrate that neuronal death after silencing can be elicited through multiple independent means of activity inhibition, and that preventing synaptic release, either alone or in combination with electrical shunting, is sufficient to elicit silencing-induced degeneration. Finally, we …

A Biblical Theology Of Water, Eric Robert Waller

Doctoral Dissertations and Projects

Numerous “water related terms” are utilized in Genesis 1-2 such as, “the deep, “the waters,” “water,” “sea,” seas,” “stream,” “river,” “flow,” “flows,” and “rain.” Arguably similar, Revelation 21-22 uses the terms “water of life,” “river of the water of life,” “thirsty,” “spring, ” and “lake.” That the traditional Protestant canon is bookended with such similar terminology appears to create an inclusio that demands further inquiry within the canon to seek supplemental, complementary, and even potentially contrasting and conflicting evidence supporting a biblical theology of water. While commentary on every canonical water related text or term would be a daunting task …

An Examination Of The Influence Of Attitudes Toward Linguistic Diversity And Immigration Status On The Pastor’S Engagement In Multicultural Ministry, Juan Antonio Seda

Doctoral Dissertations and Projects

With the growth in cultural diversity comes the opportunity to reach and minister to people from different cultural backgrounds. This diversity also highlights the challenges pastors and ministry leaders face in implementing efforts to reach people from diverse ethnic, linguistic, and cultural backgrounds. Additionally, the pastor and ministry leader must understand how socio-political, theological, and biblical factors influence opinion and interaction with culturally diverse people. This cultural and linguistic interaction requires cultural humility, “a process of reflection and lifelong inquiry, involves self-awareness of personal and cultural biases as well as awareness and sensitivity to significant cultural issues of others. Core …

Understanding Foster Care Elopement And Impact On Well-Being: A Phenomenological Study, Dana Monette Hart-Raynor

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand how elopement behaviors impacted short- and long-term well-being and daily functioning of older youth participating in North Carolina’s Foster Care 18 to 21 Program and foster care alumni in North Carolina. The theories guiding this research study were Bowlby’s attachment theory, Bronfenbrenner’s ecological systems theory, and Maslow’s hierarchy of needs. Fragmented relationships with foster caregivers were intensified with frequent elopement behaviors and problematic interpersonal relationships continued to manifest after foster care exiting. Fostered youth, their caregivers, child welfare professionals, and the community-at-large were impacted by the youth’s decision to elope. The …

Technology Acceptance Model (Tam) And Use And Adoption Of Technology By Small Business Owners In Queens, Ny, Gavin Singh

Doctoral Dissertations and Projects

Many small businesses today experience apprehension or anxiety when adopting new and emerging technologies in their place of business. Though we live in a time of unparalleled access to technology, many businesses still avoid adopting technology or upgrading to the latest version. Despite knowing the advantages of using technology to conduct business (in-person or on the Internet), some businesses purposely choose to not use technology. The purpose of this phenomenological qualitative case study was to understand why these businesses choose to do so, and to learn what can be done to help them overcome these barriers to technological adoption. The …

Vbc Young Families Initiative, Andrew Ryan Scoggins

Doctoral Dissertations and Projects

This research project is designed for Victory Baptist Church in Weatherford, Texas, to reach young families. The purpose is to design and implement a plan that educates, equips, and engages individual church members to evangelize young families in Weatherford. The necessity of this research is evident in the face of consequences surrounding the past three years involving the pandemic and a leadership change at VBC. The intervention is mobilizing the members of VBC to reach young families. This mobilization centers around training the membership to reach young families. Using surveys and questionnaires with the membership reveals what are the thoughts …

Translating Big Data To Clinical Outcomes In Anxiety: Potential For Multimodal Integration, Parmis Khosravi, André Zugman, Paia Amelio, Anderson M. Winkler, Daniel S. Pine

School of Medicine Publications

Purpose of the Review

This review describes approaches to research on anxiety that attempt to link neural correlates to treatment response and novel therapies. The review emphasizes pediatric anxiety disorders since most anxiety disorders begin before adulthood.

Recent Findings

Recent literature illustrates how current treatments for anxiety manifest diverse relations with a range of neural markers. While some studies demonstrate post-treatment normalization of markers in anxious individuals, others find persistence of group differences. For other markers, which show no pretreatment association with anxiety, the markers nevertheless distinguish treatment-responders from non-responders. Heightened error related negativity represents the risk marker discussed in …

The Polyamine Spermine Potentiates The Propagation Of Negatively Charged Molecules Through The Astrocytic Syncytium, Jan Benedikt, Christian J Malpica-Nieves, Yomarie Rivera, Miguel Méndez-González, Colin G Nichols, Rüdiger W Veh, Misty J Eaton, Serguei N Skatchkov

2020-Current year OA Pubs

The interest in astrocytes, the silent brain cells that accumulate polyamines (PAs), is growing. PAs exert anti-inflammatory, antioxidant, antidepressant, neuroprotective, and other beneficial effects, including increasing longevity in vivo. Unlike neurons, astrocytes are extensively coupled to others via connexin (Cx) gap junctions (GJs). Although there are striking modulatory effects of PAs on neuronal receptors and channels, PA regulation of the astrocytic GJs is not well understood. We studied GJ-propagation using molecules of different (i) electrical charge, (ii) structure, and (iii) molecular weight. Loading single astrocytes with patch pipettes containing membrane-impermeable dyes, we observed that (i) even small molecules do not …

Dual-Country Middle School Science Air Quality Curriculum Guide, Cassandra R. Sendra

Honors Capstones

The focus of this unit is to engage and enrich students’ perspectives on the human impact on Earth in different areas of the world. This unit will allow students to interact and learn about students in another country, learn about the air quality similarities and differences and what could affect the results of testing the air quality in two communities in different parts of the world. The goal of this unit is to have the students understand how humans impact the world around them and to compare their community to another community. The students will be accomplishing this goal utilizing …

Teaching A Hybrid Administrative Law Simulation Class Using Jurassic Park, Roberto L. Corrada

Journal of Legal Education

No abstract provided.

Biomechanical And Sensory Feedback Regularize The Behavior Of Different Locomotor Central Pattern Generators, Kaiyu Deng, Alexander J. Hunt, Nicholas Szczecinski, Matthew Tresch, Hillel J. Chiel, Charles Heckman, Roger Quinn

Mechanical and Materials Engineering Faculty Publications and Presentations

This work presents an in-depth numerical investigation into a hypothesized two-layer central pattern generator (CPG) that controls mammalian walking and how different parameter choices might affect the stepping of a simulated neuromechanical model. Particular attention is paid to the functional role of features that have not received a great deal of attention in previous work: the weak cross-excitatory connectivity within the rhythm generator and the synapse strength between the two layers. Sensitivity evaluations of deafferented CPG models and the combined neuromechanical model are performed. Locomotion frequency is increased in two different ways for both models to investigate whether the model’s …

Association Of Serum Prolactin And Glycemic Status With Retinopathy Among Type 2 Diabetic Male, Abdelkarim A. Abdrabo

Muthanna Medical Journal

Diabetic Retinopathy (DR) is one of the long-term complications of Diabetes Mellitus (DM) and constitutes the leading cause of blindness in working-age individuals. Prolactin (PRL) is a peptide hormone that is linked with lactation, but many studies have demonstrated that PRL could have protective value against DR. The aim of this study is to evaluate the role of prolactin in pathophysiology of DR. This study is designed to find an association between PRL level and DR. In this case-control study, a total of 300 subjects were recruited to participate in the study,150 subjects apparently healthy as control group and other …

The Effects Of Social Media On Internalizing Disorders In Adolescents, Deziree Wiegmann

Counselor Education Capstones

This platforms capstone project paper is about the effects that social media or advanced technology platforms has on young individuals. Many articles were reviewed, which included research studies on the prevalence of social media usage by adolescents, along with its negative and positive effects on their development. This topic is important for counselors to review in order to treat young clients that struggle with depression, anxiety, self-esteem issues, etc. For counselors and other professionals who work with adolescents, it would be important to look at the data, which has helped derive what treatment approaches may be the most effective and …

Relationship Between Protein And Secondary Metabolite Content In Congeneric Tropical Shrubs, Anna Billings

Fall Student Research Symposium 2022

Secondary metabolites are important defensive compounds found in plants which deter pests and pathogens and play an important role in defending against herbivory and seed predation. The role of secondary metabolites in fruits is complex as plants must defend the costly fruits while also successfully attracting dispersers. Protein investment into fruits is costly for plants but can serve as a reward to dispersers. In this experiment, we examined the protein content of plant tissues and compared it with the secondary metabolite content. We extracted and measured protein content of leaf and fruit pulp tissues from 15 species of Psychotria (a …

Would You Like To Come Out And Play?, Leslie Miklosy

Erma Bombeck Writers' Workshop Blog

I have a confession to make: I’m a middle-aged fellow who likes to play. I will, for instance, while in the throes of a particular mood, pretend to lunge at our family dog. The dog — smart animal that he is — picks up on the counterfeit attack and off we go, enjoying our merry little dance.

The Advancement Of Surrealism: Navigating The Logical Implications Of Surrealism In Poetry Through Time, Brandon Hemsworth

Honors Projects

Surrealism is a complex medium of artistic expression that has persisted through the modern and postmodern time periods and into the contemporary. This project attempts to shine light on the importance of Surrealism by researching the rational implications of its irrational nature. I approached this question in two separate manners: One in a research perspective and one in a creative perspective. This project includes my research on the advancement of Surrealism and 15 poems that I have composed in reflection of Surrealism, Modernism, Postmodernism, the contemporary, and Anti-Realism. The conclusions of this project have important implications that have a common …

Induction Of Multiple Immune Signaling Pathways In Gryllodes Sigillatus Crickets During Overt Viral Infections, Kristin R. Duffield, Bert Foquet, Judith A. Stasko, John Hunt, Ben M. Sadd, Scott K. Sakaluk, José L. Ramirez

Faculty Publications – Biological Sciences

Despite decades of focus on crickets (family: Gryllidae) as a popular commodity and model organism, we still know very little about their immune responses to microbial pathogens. Previous studies have measured downstream immune effects (e.g., encapsulation response, circulating hemocytes) following an immune challenge in crickets, but almost none have identified and quantified the expression of immune genes during an active pathogenic infection. Furthermore, the prevalence of covert (i.e., asymptomatic) infections within insect populations is becoming increasingly apparent, yet we do not fully understand the mechanisms that maintain low viral loads. In the present study, we measured the expression of several …