Digital Commons Network^™

Gator2-Dependent Mtorc1 Activity Is A Therapeutic Vulnerability In Foxo1 Fusion-Positive Rhabdomyosarcoma, Jacqueline Morales, David V. Allegakoen, José A. Garcia, Kristen Kwong, Pushpendra K. Sahu, Drew A. Fajardo, Yue Pan, Max A. Horlbeck, Jonathan S. Weissman, W. Clay Gustafson, Trever G. Bivona, Amit J. Sabnis

Student Publications

Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor survival; to date, these cancer drivers are therapeutically intractable. To identify new therapies for this disease, we undertook an isogenic CRISPR-interference screen to define PAX3-FOXO1-specific genetic dependencies and identified genes in the GATOR2 complex. GATOR2 loss in RMS abrogated aa-induced lysosomal localization of mTORC1 and consequent downstream signaling, slowing G1-S cell cycle transition. In vivo suppression of GATOR2 impaired the growth of tumor xenografts and favored the outgrowth of cells lacking PAX3-FOXO1. Loss of a subset of GATOR2 members can be compensated by direct genetic activation of mTORC1. …

Focusing Of High-Amplitude Sound Waves Using The Time Reversal Process, Brian D. Patchett

Theses and Dissertations

Time reversal is a method often used to focus sound to a desired location, and works best in a reverberant environment. The effect of focus location within a reverberant environment is presented first, revealing that proximity to reflecting surfaces has a significant effect on the amplitude of the focus both experimentally and when using a modal summation model. These effects are a primary component to creating focus signals at high amplitudes. High-amplitude focusing experiments show that when multiple sources are used simultaneously to generate a focus, a peak amplitude pressure spike of 200 dB can be achieved in air. A …

The Resident View In Community- Based Care Residential Settings, Diana L. White, Ozcan Tunalilar, Serena Hasworth, Jaclyn Winfree

Institute on Aging Publications

The Resident VIEW is a measure of person-centered care (PCC) from residents’ perspectives and was previously studied in nursing homes. The current study presents descriptive data for the Resident VIEW in community-based care settings including assisted living, residential care (AL/RC), and adult foster homes (AFH). Using a two-stage sampling design, we recruited 31 AL/RC and 119 AFH in Oregon and completed face-to-face structured interviews with 227 and 195 residents, respectively. Residents provided ratings for both the importance of and their experience with 66 items that tapped into PCC practices in eight domains. Results are provided for each item, many of …

Evaluation Of Library Websites Of Colleges Affiliated To University Of Delhi: A Content Analysis Study, Kajal Narula, Paramjeet Kaur Walia

Library Philosophy and Practice (e-journal)

Abstract

Purpose- This paper aims to analyse the content of libraries’ websites of colleges affiliated to University of Delhi in India.

Design/methodology/approach-In the present study, observation method was used to analyse the content which was uploaded on the websites of selected ten colleges of University of Delhi. The data and content uploaded on the websites was collected and analysed with the help of checklist specifically designed for this purpose.

Findings- Most of the college libraries uploaded information about its collection on the website. It was found that few college libraries have been using web 2.0 tools. It has been …

Ecological Niche Modeling Of The Macedonian Mouse, Mus Macedonicus (Mammalia, Rodentia), Under Climate Change Conditions, S Dermitas, Ne Gunduz, David T. Bilton

School of Biological and Marine Sciences

Mus macedonicus Petrov & Ružic, 1983, also known as the Macedonian mouse or Balkan short-tailed mouse, lives in the southern Balkans and the Middle East. While this species is common in Mediterranean ecosystems and is listed as “least concern” by the IUCN, little is known about how its distribution may shift with climate change. This study explores the ‘species’ potential distribution in three different periods: during the Last Glacial Maximum (LGM) and under current and future climate scenarios, using Maximum Entropy modelling. Modelling was based on 137 georeferenced occurrence records from Macedonia, Bulgaria, Greece, Turkey, Syria, Lebanon, Israel, Iran, Georgia, …

The Student Movement Volume 107 Issue 11: Have A Merry Christmas! Xoxo, The Student Movement, Solana Campbell, Caryn Cruz, Grace No, Gloria Oh, Nathaniel Reid, Skylor Stark, Ysabelle Fernando, Ceiry Flores, Hannah Cruse, Alexander J. Hess, Alexander Navarro, Rachel Ingram-Clay, Elizabeth Getahun, Kayla-Hope Bruno, Wambui Karanja, Lexie Dunham, Reagan Mccain, Melissa Moore, Elizabeth Dovich

The Student Movement v. 107 (2022-2023)

HUMANS

Coping with Finals, Solana Campbell

Meet Jea Erazo, AUSA Public Relations Officer. Interviewed by: Caryn Cruz

Remembering Sharon Dudgeon, Grace No

Women in STEM: Olivia Joyce, Interviewed by: Gloria Oh

ARTS & ENTERTAINMENT

Football Sunday, Nathaniel Reid, Skylor Stark

Student Picks: Christmas Classics, Ysabelle Fernando

NEWS

AFIA x MLS Christmas Party, Ceiry Flores

Boycotts and Bans at the Qatar World Cup, Hannah Cruse

In Loving Memory of Seth Williams, Gloria Oh

IDEAS

How Do We Address Queer Violence?, Alexander J. Hess

Is Reality Really Real When You Aren't Really Looking?, Alexander Navarro

Reflecting on Christmas Traditions, Rachel Ingram-Clay

The …

Vista: December 8, 2022, University Of San Diego

USD Vista (1965-)

No abstract provided.

The Kenyon Collegian - December 8, 2022

The Kenyon Collegian

No abstract provided.

The Time Is Right For An Antarctic Biorepository Network, Kristin M. O’Brien, Elizabeth L. Crockett, Bryon J. Adams, Charles D. Amsler, Hannah J. Appiah-Madson, Allen Collins, Thomas Desvignes, Sarah Eppley, Multiple Additional Authors

Biology Faculty Publications and Presentations

Antarctica is a central driver of the Earth’s climate and health. The Southern Ocean surrounding Antarctica serves as a major sink for anthropogenic CO2 and heat (1), and the loss of Antarctic ice sheets contributes significantly to sea level rise and will continue to do so as the loss of ice sheets accelerates, with sufficient water stores to raise sea levels by 58 m (2). Antarctica's marine environment is home to a number of iconic species, and the terrestrial realm harbors a remarkable oasis for life, much of which has yet to be discovered (3). Distinctive oceanographic features of the …

The Protein Phosphatase 2a Holoenzyme Is A Key Regulator Of Starch Metabolism And Bradyzoite Differentiation In Toxoplasma Gondii, Jin-Lei Wang, Ting-Ting Li, Hany M Elsheikha, Qin-Li Liang, Zhi-Wei Zhang, Meng Wang, L David Sibley, Xing-Quan Zhu

2020-Current year OA Pubs

Phenotypic switching between tachyzoite and bradyzoite is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite Toxoplasma gondii. Although accumulation of cytoplasmic starch granules is a hallmark of the quiescent bradyzoite stage, the regulatory factors and mechanisms contributing to amylopectin storage in bradyzoites are incompletely known. Here, we show that T. gondii protein phosphatase 2A (PP2A) holoenzyme is composed of a catalytic subunit PP2A-C, a scaffold subunit PP2A-A and a regulatory subunit PP2A-B. Disruption of any of these subunits increased starch accumulation and blocked the tachyzoite-to-bradyzoite differentiation. PP2A contributes to the regulation of amylopectin metabolism via dephosphorylation …

Trying To Capture, Cautiously, The O'Malley Style, James F. Keenan Sj

Jesuit Higher Education: A Journal

John W. O’Malley, S.J., has proffered and used the concept of style so as to name something other than content that is needed in order to understand argument or research. In a way, style is to contemporary argument what rhetoric was to grammar. This essay attempts to capture what O’Malley means by style, but also, and more importantly seeks to describe or capture O’Malley’s own style. By employing the different formats that Jesuit Higher Education: A Journal offers, the essay tries to highlight the relevance and richness of style in communicating the self to the other. In a word, style …

John O’Malley And Jesuit Education: A Journey Into Humanism, Cristiano Casalini, Alessandro Corsi

Jesuit Higher Education: A Journal

This article reflects upon the impact of the work of John W. O’Malley, S.J. (1927–2022), on the field of the history of Jesuit education. In The First Jesuits (1993), O’Malley provided an innovative approach to the subject that refuted some long-standing preconceptions about the way Jesuit schools and universities had originally developed. The approach that he took to to the topic throughout the 1990s and 2000s allowed him to identify two intertwined educational traditions at the heart of the Jesuit pedagogical model: the humanistic tradition of the Renaissance period, based on the Isocratic concept of pietas, and the scholastic …

Remembering John O'Malley, S.J., John J. Degioia

Jesuit Higher Education: A Journal

No abstract provided.

The Arithmetic Of Want, Ion Corcos

The Woodward Review: A Creative and Critical Journal

No abstract provided.

In The Wild // On Charles Darwin's Theory Of Evolution, Nnandi Samuel

The Woodward Review: A Creative and Critical Journal

No abstract provided.

(From) Dreamlife Of Honey, Marcus Slease

The Woodward Review: A Creative and Critical Journal

No abstract provided.

Full Issue: The Woodward Review 2.1 Winter 2022, The Woodward Review Editors

The Woodward Review: A Creative and Critical Journal

No abstract provided.

Accessibility Of University Course Syllabi, Steven M. Baule, Sara A. Fister

Essays in Education

Over the last twenty years, governments and a range of disability rights organizations have advocated for increased accessibility to educational materials and school documents for people with disabilities. Recently, several studies have shown that accessibility is still lagging among educational institutions and other government agencies. The purpose of this study was to analyze extant higher education syllabi to determine the level of compliance with the current Web Content Accessibility Guidelines (WCAG 2.0). The study reviewed the current accessibility requirements for schools under WCAG 2.0 and Section 508 of the Rehabilitation Act as amended in 2018. It then provides a review …

Stem And High School Students With Disabilities: A Qualitative Review Of The Research Literature, Scott Yamamoto Ph.D., Charlotte Y. Alverson Ph.D., Laura Mccoid-Goudy M.A.T., Hannah Castle B.A., Jacquelyn Burr M.Ed.

Journal of Science Education for Students with Disabilities

We conducted a qualitative review of the research literature on STEM (science, technology, engineering, mathematics) related to high school students with disabilities (SWD). We selected and analyzed 53 articles to answer two questions: (1) How are high-school SWD prepared for careers in STEM? (2) How are educators prepared to support high-school SWD for opportunities in STEM? In answering the first question, four qualitative themes emerged: (a) barriers to STEM, (b) increasing STEM opportunities, (c) STEM readiness in college and career, and (d) STEM identity. In answering the second question, three qualitative themes emerged: (a) individualizing learning and supports for SWD, …

Growing In Faith, Sarah Moss

The Voice

No abstract provided.

Worldwide Distribution Of Cave-Dwelling Chelodesmidae (Diplopoda, Polydesmida), Rodrigo Salvador Bouzan, Jackson C. Means, Kaloyan Ivanov, Rodrigo L. Ferreira, Antonio Domingos Brescovit, Luiz Felipe Moretti Iniesta

International Journal of Speleology

Chelodesmidae is one of the most species rich families within the Myriapoda. However, little is known regarding their association with caves. We provide a list of all Chelodesmidae taxa reported from caves, map their worldwide distribution, and discuss the troglomorphic features of the group. A total of 25 species and subspecies from 20 genera and 2 subfamilies have been recorded from 59 caves and cave systems in 11 countries. These numbers represent a surprisingly modest proportion (~3%) of the approximately 800 described species in the family. Records of cave-dwelling chelodesmids appear to be geographically biased with most taxa reported from …

The Influence Of Incorporating Modern Technologies Into The Legal Curriculum As Effective Teaching Approach In Higher Education, Tripti Bhushan

Indonesian Journal of International Law

Higher education has seen a tremendous increase in the use of technology in teaching and learning. In this context, technology would play an important part in the law school curriculum inside and outside the classroom. This would allow students to explore various aspects of the legal world beyond the classroom, and the integration provides law schools with a potent weapon. Therefore, this research focused on using technology in teaching and learning, which would significantly aid in addressing law students’ learning requirements. By examining successful technology, it uncovered the gaps between the usage and understanding of International Law. The curriculum offered …

Understanding The Failure Of Police Reform In Nigeria: A Case For Legal History Through Literature, Olaoluwa Folasade Oni

LLM Theses

On the 21st of October 2020, the world woke to images and video clips of the bloodied, broken bodies of Nigerians shared across social and traditional media. The night before, young Nigerians protesting police brutality were met with a government-sanctioned, combined police and military onslaught; Nigerias decades-long struggle with police dysfunction was brought to a head with the massacre of its citizens at the Lekki toll gate on the evening of October 20, 2020. This work problematizes the cycle of attempts at, and ultimate failure of, police reform in Nigeria. I argue that the colonial nature of policing is retained …

Review Of Conceptualizations, Peer Interventions, And Principles And Standards In Approaches To Intimate Partner Violence (Ipv), Sara Fister

Counselor Education Capstones

Intimate partner violence (IPV), a type of domestic violence, is a human rights issue that is considered a global health concern. The daunting statistics outline the immense need for principles and standards for approaches to IPV. The overarching goal of this review is to explore peer support and peer mentorship as a potential adjunct service to a comprehensive service program for IPV victim-survivors. Conceptualization, theory, and frameworks; social support and peer support; the self-identity of IPV victims; single versus integrative services; service enhancement; evaluation; and advocacy and interventions are investigated in relation to IPV services, in general, and peer support, …

Occupational Therapy Program Research Seminar, Kelly L. Taylor Otd, Ms, Otr/L, Cbis

Student Scholarship & Creative Works

Occupational Therapy Program Research Seminar

December 7, 2022 │ 8:30AM – 12:30PM

Murray State University, Paducah Regional Campus

2022 Fall Engr333 Project Section A Final Report, Dat Cao, Sam Hoover, Sawyer Masselink, Ian Vanderkooi, Matthew Carlson, Jacob Heeres, Anthony Nykamp, Jacob Wyngarden, Nate Anderson, Anna Giboney, Gia Mien Le, Jonathan Washburn, Jess Camp, Aubree Peters, Alin Stoica, Drew Stoneburner, Claire Sheppard, Alayna Spiering, Reid Veneman, James Viel

ENGR 333

Calvin University has committed to being carbon neutral by 2057. This entails removing all the natural gas consumption for heating, converting to electrical heating options, and then making carbon free electricity. This project looked into four different options: air source heat pumps, ground source heat pumps, renewable natural gas, and the efficiency of current equipment. Each option was examined throughout the course of the semester to determine feasibility of each solution, and which ones would be best to implement. As a class, section A decided ground source heat pumps along with thermostatic valves and the implementation of double pane windows …

The Effects Of Raising A Child With Companion Animals, Abby Murcray

Fall Student Research Symposium 2022

What were the effects on children who were raised with companion animals? As someone who has grown up with companion animals most of my life, I wanted to learn what impact the animals had on my growth and development. The research was conducted using library and internet resources to locate both primary and secondary resources. For this study, I looked at specific studies done on children that are surrounded by companion animals versus those that are not, using mostly Utah State's Academic Search Ultimate to find my sources. Raising a child with a domestic animal benefits a child in many …

Pseudo-Embryology And Personhood: How Embryological Pseudoscience Helps Structure The American Abortion Debate, Scott F. Gilbert

Biology Faculty Works

There is a pseudo-embryology flourishing today, well nourished by popular science, religious ideologies, and the public media. Just as eugenics was a pseudoscience that influenced (and still influences) American popular culture and which was responsible for racist anti-immigration laws (such as the Immigration Restriction Act of 1924), pseudo-embryology is also influencing popular culture and legislation. This new pseudoscience promotes the belief that science supports current zygotic and fetal personhood movements as well as anti-abortion legislation. However, what often passes for science are actually ideological myths, often grounded in and supporting male superiority. Indeed, the first myth of pseudo-embryology is that …

Pause And Possibility: Pre-Service Teachers’ Perspectives On Creative Writing Clubs, Stephanie Altier

Honors Projects

Creative writing clubs can enrich the lives of writers and facilitators. These clubs provide many opportunities to enrich their members’ academic, social, and personal development (Clifton, 2022; Siskel & Jacobs, 2011; Lawton, 2021). This project uses a focus-group study of five pre-service Integrated Language Arts teachers to explore the teachers' perspectives on advising creative writing clubs. Their insight informs a web-based teacher resource, Creative Writing Club Hub. Major findings are that participants harbor low self-efficacy towards creative writing and that the most effective method for encouraging them to advise these clubs may be to create a creative writing community …

Mimosa 2021/2022, Jacksonville State University

JSU Yearbooks

The JSU Yearbook Collection spans the years from 1926 to the present. The publication began in 1926 as the Teacola (some volumes spelled "Teacoala") and continued under this title through 1933. The yearbook appears to have ceased printing after that year; the student newspaper took the name Teacola (later changed to the Collegian and finally the Chanticleer) and began publication in 1934. The yearbook started up again in 1947 under the name Mimosa. The Library holds all volume years that were printed: 1926-1933, 1947-1950, 1952-present.