Digital Commons Network^™

Gabapentin Disrupts Binding Of Perlecan To The Α 2Δ1 Voltage Sensitive Calcium Channel Subunit And Impairs Skeletal Mechanosensation, Perla C Reyes Fernandez, Christian S Wright, Adrianna N Masterson, Xin Yi, Tristen V Tellman, Andrei Bonteanu, Katie Rust, Megan L Noonan, Kenneth E White, Karl J Lewis, Uma Sankar, Julia M Hum, Gregory Bix, Danielle Wu, Alexander G Robling, Rajesh Sardar, Mary C Farach-Carson, William R Thompson

Faculty, Staff and Student Publications

Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering elements" (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals. While we identified the heparan sulfate proteoglycan perlecan (PLN) as a component of these TEs, PLN must attach to the cell surface to induce biochemical responses. As voltage-sensitive calcium channels (VSCCs) are critical for bone mechanotransduction, we hypothesized that PLN binds the extracellular α2δ1 subunit of VSCCs to couple the bone matrix to the osteocyte membrane. Here, we showed co-localization of PLN and α2δ1 along …

Outdoor Recreation And Its Effect On Our Relationship With The Environment, Martin Brannaman

Department of Environmental Studies: Undergraduate Student Theses

This study was conducted at the University of Nebraska Outdoor Adventure Center. This study employed a pre-post retrospective assessment looking at individuals' connection with nature after embarking on a direct outdoor experience. A direct outdoor experience is when an individual is outside and not surrounded by manmade structures (Kil, 2016). I believe that after a direct outdoor experience the sample group will have a significant change in their connection to nature. The objective is to measure change in a group's connection to nature, through the Connectedness to Nature Scale (CNS, Mayer & Frantz, 2004). The population was a group of …

Eastern Redcedar Reduces Regeneration And Diversity In The Forests Of The Niobrara River Valley, Abigail Ridder

Department of Environmental Studies: Undergraduate Student Theses

Boundary forests are found growing interdigitated with grasslands across the Great Plains. The Niobrara River valley boundary forest has a unique composition of species not seen anywhere else in North America. Encroachment of eastern redcedar (Juniperus virginiana L.) into grasslands and forests is significantly increasing eastern redcedar’s presence in the Niobrara River Valley as well as in the rest of the Great Plains region. This tree species is capable of significantly decreasing recruitment and diversity in grasslands, which can change the composition of the entire ecosystem. However, the effect of eastern redcedar on recruitment and diversity of naturally forested ecosystems …

Teaching Autistic Children To Independently Wash Their Hands: A Systematic Review Of Behavioral Techniques, Alexis Vazquez

Seton Hall University Dissertations and Theses (ETDs)

With COVID 19 having changed the world’s perception on daily hygiene, people are aiming to improve the rate and efficacy of their hand washing. Autistic children, having a history of challenges with daily living skills, may need support when learning the skill of hand washing. The current review discusses interventions used to teach autistic children effective hand washing and investigates if those interventions meet criteria to be considered an evidence-based practice. Six studies met the inclusion criteria and data were synthesized narratively. Given the importance of hand washing in society, more research is necessary to achieve optimal outcomes. The review …

Identity Work To Teach Mathematics For Social Justice, Navy B. Dixon

Theses and Dissertations

In this thesis, mathematics educators are conceptualized as individuals with multiple, simultaneous figured worlds that inform their decisions while planning. The study explores how two mathematics educators negotiated and orchestrated their figured worlds to plan two mathematics lessons for social justice. The results highlight how numerous the figured worlds each participant surfaced through background interviews. Some of the figured worlds were elicited by the interview questions (i.e., Race, Family, Social Justice Teaching) but other figured worlds organically surfaced through the interviews (i.e., Sexuality, Community, Activism, Critical Information Consumption). A discursive analysis of a selection of these figured worlds revealed conceptualizations …

Quantifying Shape Variation In An Antisymmetrical Trait In Xenophallus Umbratilis, Mary-Elise Johnson Nielsen

Theses and Dissertations

Antisymmetry is a striking, yet puzzling form of biological asymmetry. The livebearing fish Xenophallus umbratilis exhibits antisymmetry in the male intromittent organ and provides a system that is well-suited for studying the nature of variation in antisymmetrical traits. Using geometric morphometrics, I test the hypothesis that because the gonopodium is critical to fitness there will not be significant differences in gonopodium shape between the two gonopodial morphs in this species. My results are consistent with this prediction, though I found that gonopodium shape did differ with gonopodium size.

Case-Control Investigation Of Invasive Salmonella Disease In Malawi Reveals No Evidence Of Environmental Or Animal Transmission Of Invasive Strains, And Supports Human To Human Transmission, Leonard Koolman, Reenesh Prakash, Yohane Diness, Chisomo Msefula, Tonney S. Nyirenda, Franziska Olgemoeller, Paul Wigley, Blanca Perez-Sepulveda, Jay C. D. Hinton, Siân V. Owen, Nicholas A. Feasey, Philip Ashton, Melita A. Gordon

Research Outputs: 2025-Present

BackgroundInvasive Salmonella infections cause significant morbidity and mortality in Sub-Saharan Africa. However, the routes of transmission are uncertain. We conducted a case-control study of index-case and geographically-matched control households in Blantyre, Malawi, sampling Salmonella isolates from index cases, healthy people, animals, and the household environment.MethodologySixty index cases of human invasive Salmonella infection were recruited (March 2015-Oct 2016). Twenty-eight invasive Non-Typhoidal Salmonella (iNTS) disease and 32 typhoid patients consented to household sampling. Each index-case household was geographically matched to a control household. Extensive microbiological sampling included stool sampling from healthy household members, stool or rectal swabs from household-associated animals and boot-sock …

Tenotomy-Induced Muscle Atrophy Is Sex-Specific And Independent Of Nfκb, Gretchen A Meyer, Stavros Thomopoulos, Yousef Abu-Amer, Karen C Shen

2020-Current year OA Pubs

The nuclear factor-κB (NFκB) pathway is a major thoroughfare for skeletal muscle atrophy and is driven by diverse stimuli. Targeted inhibition of NFκB through its canonical mediator IKKβ effectively mitigates loss of muscle mass across many conditions, from denervation to unloading to cancer. In this study, we used gain- and loss-of-function mouse models to examine the role of NFκB in muscle atrophy following rotator cuff tenotomy - a model of chronic rotator cuff tear. IKKβ was knocked down or constitutively activated in muscle-specific inducible transgenic mice to elicit a twofold gain or loss of NFκB signaling. Surprisingly, neither knockdown of …

Place Cells Dynamically Refine Grid Cell Activities To Reduce Error Accumulation During Path Integration In A Continuous Attractor Model, Jose A Fernandez-Leon, Ahmet Kerim Uysal, Daoyun Ji

Faculty, Staff and Students Publications

Navigation is one of the most fundamental skills of animals. During spatial navigation, grid cells in the medial entorhinal cortex process speed and direction of the animal to map the environment. Hippocampal place cells, in turn, encode place using sensory signals and reduce the accumulated error of grid cells for path integration. Although both cell types are part of the path integration system, the dynamic relationship between place and grid cells and the error reduction mechanism is yet to be understood. We implemented a realistic model of grid cells based on a continuous attractor model. The grid cell model was …

Divergent Post-Breeding Spatial Habitat Use Of Laysan And Black-Footed Albatross, Fredrick Dallas Jordan, Scott A. Shaffer, Melinda G. Conners, Julia E.F. Stepanuk, Morgan E. Gilmour, Corey A. Clatterbuck, Elliott L. Hazen, Daniel M. Palacios, Yann Tremblay, Michelle Antolos, David G. Foley, Steven J. Bograd, Daniel P. Costa, Lesley H. Thorne

Faculty Research, Scholarly, and Creative Activity

Understanding the at-sea movements of wide-ranging seabird species throughout their annual cycle is essential for their conservation and management. Habitat use and resource partitioning of Laysan (Phoebastria immutabilis) and black-footed (Phoebastria nigripes) albatross are well-described during the breeding period but are less understood during the post-breeding period, which represents ~40% of their annual cycle. Resource partitioning may be reduced during post-breeding, when birds are not constrained to return to the nest site regularly and can disperse to reduce competitive pressure. We assessed the degree of spatial segregation in the post-breeding distributions of Laysan (n = 82) and black-footed albatrosses (n …

Art And Its Importance To Social-Emotional Learning And Behavior Management In The Classroom, Ashley Joustra

Art 895 Research Papers

This case study examines the association between an arts education and social-emotional learning (SEL) and attempts to identify if an increased social competence positively affects behavior in the classroom. Education policies are explored as well as outcomes of SEL through art programs. Organizations promoting the SEL such as CASEL and educational plans highlighting art/SEL integration from the UChicago Consortium of School Research are studied. Behavior data from CUSD 300 in northwestern Illinois is examined in relation to art and SEL education.

Idaho Public Land Access: Amending Road Laws To Ensure Public Land Remains Accessible, Jillian Greene

Idaho Law Review

No abstract provided.

Potential Effects Of Snake River Dam Removal On Salmonids, Lucius Caldwell

Idaho Law Review

No abstract provided.

The Mistake On The Snake: The Lower Snake River Dams, Michael C. Blumm

Idaho Law Review

No abstract provided.

Modernist And Post-Modernist Paradigms: A Forged Art Education Curriculum, Raelissa Hovelson

Art 895 Research Papers

The purpose of this study is to consider a curriculum that uses the best characteristics of both modernist and pos-tmodernist approaches to art education, and showcases artists that model the forged curriculum. A modernist approach to art education has students emulate the technical skills that has prevailed the Western culture of classical artists. A post-modernism approach is the idea that art education should be more about multiculturalism, social engagement, equity, diversity, and inclusion. Using a qualitative case study, a literature review is analyzed to understand both modernist and post-modernist paradigms. Through discussion, artists that model characteristics from both teaching approaches …

Exploring Anti-Racism In The First Year Legal Writing Classroom, Amanda K. Maus Stephen

Presentations

The Legal Writing Institute hosted a series of one-day workshops at various law schools, including at SU, where the theme of the workshops was "Teaching Values in the Legal Writing Classroom." This presentation explores assignments and activities that legal writing professors can use to introduce and reinforce ant-racism as a critical professional value.

2022 Commencement Program - Fall, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2022 Fall Commencement program for Morehead State University.

Art Activism In The Elementary Art Classroom: A Case Study, Julian Kramer

Art 895 Research Papers

This research is focused on the integration of art activism into the elementary art curriculum. It begins with an overview of four contemporary artists known for their activist works. A review of recent literature related to art activism and art education follows. While there were many articles discussing art activism in art education curricula, integrating art activism at the elementary level is not well documented. It concludes with a discussion of these artists and the recent literature, with suggestions for age-appropriate activism-based art projects for elementary students.

Teknik Fermentasi Campuran Bahan Organik Sebagai Sumber Nutrisi Organik Pada Sayuran Sawi Yang Ditanam Dengan Hidroponik, Darwin H. Pangaribuan, Yohannes Cahya Ginting, Rugayah, Purba Sanjaya, Agus Karyanto, Kurnia Cahyani Dewi, Intan Puspita Sari

Jurnal Kultivasi

Nutrisi organik untuk budidaya sistem sumbu hidroponik merupakan salah satu alternatif untuk mengatasi kendala mahalnya harga pupuk anorganik. Penelitian ini bertujuan untuk mengetahui metode ekstraksi terbaik antara metode air hangat, air dingin, dan fermentasi kemudian menentukan waktu fermentasi terbaik dari unsur hara organik campuran rumput laut, sabut kelapa dan daun kelor yang diharapkan memiliki kandungan nutrisi organik yang mendekati dengan formula nutrisi anorganik. Penelitian ini terdiri atas 2 percobaan: (i) percobaan pertama meneliti jenis metode ekstraksi, dan (ii) percobaan kedua meneliti waktu fermentasi terbaik. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan faktor tunggal dan diulang sebanyak 6 …

Microplastic Accumulation In The Digestive Tract Of Young-Of-Year Atlantic Sharpnose Sharks (Rhizoprionodon Terraenovae) In The Grand Strand, Sc, Andrew Curtis Sitlinger

Electronic Theses and Dissertations

This study focused on the presence and accumulation of microplastic fibers in the digestive tract and livers of young-of-year Atlantic Sharpnose Sharks (Rhizopriondon terraenovae) from two sampling locations along the Grand Strand of South Carolina. R. terraenovae is a small, mesopredatory elasmobranch found abundantly along northwestern Atlantic Ocean coastlines. Thirty specimens of R. terraenovae were collected from May through August of 2020. Microplastics were found in all specimens. A total of 672 plastic particles were identified over the course of the study, with an average of 22.4 ± 10.5 (SD) plastics per specimen. The majority of the plastics were classified …

Fine-Scale Site Selection Of Strand-Feeding Common Bottlenose Dolphins (Tursiops Truncatus) And Their Prey, Deborah Kleinclaus

Electronic Theses and Dissertations

Strand-feeding is a unique, cooperative foraging strategy used by some common bottlenose dolphins (Tursiops truncatus) at low tide in South Carolina and Georgia salt marshes, where a group of dolphins charges schools of fish, thrusting them onto the bank with their bow wave and then capturing prey items onshore. Strand-feeding dolphins are estuarine residents and frequent predictable stranding sites, suggesting an intimate knowledge of the area. Dolphin behavior prior to stranding suggests they do not herd the fish before charging, but instead prey on fish already shoaling near the bank. The use of active acoustics from strand-feeders in order to …

Habitat Use And Diel Movements Of Silver Carp Hypophthalmichthys Molitrix In Two Southeastern Reservoirs, Levi Umland

Honors College Theses

Bigheaded carp have spread rampantly throughout the Mississippi watershed and continue to spread by navigating through rivers, locks, and dams. The long-term effects these species will have on our ecosystems and natural resources is unknown. Their movements, behavior, and general seasonal patterns are well studied within rivers. However, their movements and behavior within reservoirs is poorly understood due to their initial numbers within reservoirs being lower than in rivers. To address this gap, I investigated the distribution and movement rates of Silver Carp within two reservoirs, Kentucky Reservoir and Barkley Reservoir, and possible correlative variables, including wind, temperature, residency, sex, …

Recolección Y Representación De Datos En Primero De Primaria Con Splash. Un Caso De Estudio, Carlos Javier González López, Martha Lidia Barreto Moreno, Felipe Eugenio Retamal Acevedo, Zandra Maritza Tarazona Carrascal, Lina Katerín Perea Zárate

Educación

La obra titulada Recolección y representación de datos en primera de primaria con Splash. Un caso de estudio. Es producto del proceso investigativo ejecutado en el marco de los proyectos titulados: Modelización computacional de hiperlugares móviles translocales.

Avanzando con el MEDIT hacia nuevos modelos educativos, y Observatorio Translocal de Calidad Educativa de la Universidad de Cundinamarca ¿ Fase II. El objetivo de este trabajo de grado es promover procesos de clasificación y organización de datos en los estudiantes de grado primero del gimnasio nuevo Bolívar, mediante la adaptación del software Splash como herramienta didáctica, para mejorar la comprensión en los …

Defective Proteostasis In Induced Pluripotent Stem Cell Models Of Frontotemporal Lobar Degeneration, Sidhartha Mahali, Rita Martinez, Melvin King, Anthony Verbeck, Oscar Harari, Bruno A Benitez, Kanta Horie, Chihiro Sato, Sally Temple, Celeste M Karch

2020-Current year OA Pubs

Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which can be toxic to cells and tissue. In a subset of frontotemporal lobar degeneration with tau pathology (FTLD-tau) cases, pathogenic mutations in the microtubule-associated protein tau (MAPT) gene are sufficient to cause tau accumulation and neurodegeneration. However, the pathogenic events triggered by the expression of the mutant tau protein remain poorly understood. Here, we show that molecular networks associated with lysosomal biogenesis and autophagic function are disrupted in brains from FTLD-tau patients carrying a MAPT p.R406W mutation. We …

Graveyard Picnic, Jackson Cook

Diamond Line Undergraduate Literary Magazine

Jackson Cook is a Junior from Little Rock, Arkansas. He can typically be found playing tennis at Wilson Park or watching unwatchable movies with his roommates. Macie Hickman- Macie Hickman is a junior Creative Writing major with a minor in Classics. She will read almost anything but loves fantasy novels above all else. Friends and family are incredibly important to her and they are the subjects she writes about the most.

Sr 22-23-14 Cc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Sizeism--What Multicultural Education & Training Are Missing, Jen Rynes

Counselor Education Capstones

Training in multiculturalism is a major focus in most counselor education graduate programs. These programs seek to graduate competent counselors who aspire to serve all populations. The harsh reality is that many programs fail to acknowledge body diversity and sizeism in these multicultural courses and trainings. There are a multitude of reasons why body diversity needs to be a part of multicultural education and training. The literature reviewed in this paper has a purpose of discussing those reasons, dismantling the many myths associated with fatness, identifying how body size intersects with other diverse identities, and reviewing current multicultural guidelines and …

Loss Of Pex1 In Inner Ear Hair Cells Contributes To Cochlear Synaptopathy And Hearing Loss., Stephanie A Mauriac, Thibault Peineau, Aamir Zuberi, Cathleen Lutz, Gwénaëlle S G Géléoc

Faculty Research 2022

Peroxisome Biogenesis Disorders (PBD) and Zellweger syndrome spectrum disorders (ZSD) are rare genetic multisystem disorders that include hearing impairment and are associated with defects in peroxisome assembly, function, or both. Mutations in 13 peroxin (PEX) genes have been found to cause PBD-ZSD with ~70% of patients harboring mutations in PEX1. Limited research has focused on the impact of peroxisomal disorders on auditory function. As sensory hair cells are particularly vulnerable to metabolic changes, we hypothesize that mutations in PEX1 lead to oxidative stress affecting hair cells of the inner ear, subsequently resulting in hair cell degeneration and hearing loss. Global …

A Call For Research: Ethical Dilemmas Of Autonomous Vehicle Manufacturers, Remy Harwood

Cybersecurity Undergraduate Research Showcase

While autonomous vehicles accounted for about 31.4 million vehicles on the road in 2019 (Placek). They have continued to flood the market and have a projected growth to 58 million in just 8 years from now (Placek) As well as a market cap in the billions of dollars. Even the comparatively new AV company Tesla has over 3 times the market cap value of the leading non AV brand Toyota (Market Cap) who are also working toward AVs as well, like their level 2 teammate driver assistance. Following Moore’s Law, as technology continues to improve, their social impact and ethical …

Comparative Intellectual Property Protection For Marijuana: United States Vs. The European Union, Jillian Gosser

Global Business Law Review

Protecting intellectual property relating to marijuana is a complicated endeavor. The federal ban on marijuana renders trademark protection difficult at best, and patent protection, while available, still rife with complications. In Europe, the laws pose similar challenges in the protection and enforcement of marijuana related intellectual property. This Note presents a comparative law analysis of the various ways marijuana related intellectual property may be protected in the United States and Europe. Different types of intellectual property protection explored include utility patents, design patents, trademarks, plant patents, Plant Variety Protection Act coverage, and Community Plant Variety Act coverage. This Note explores …