Digital Commons Network^™

Unclean And Unforgivable, Cindy Pope

Master of Arts in Professional Writing Capstones

Abstract

Unclean and Unforgiveable

Unclean and Unforgiveable is a historical medical drama wherein the protagonist, Victoria Evans, travels to Richmond, Virginia, to become a nurse trainee in 1862. Using archival and bibliographic research, this writer constructed authoritative, realistic, and emotionally charged scenes for readers to experience the brutalities of war and the harsh realities of nursing in the South. Yet for all her laborious duties carried out with diligence and devotion, Victoria’s beloved Virginia is decimated, and her family is destroyed. Her one marketable skill is nursing using proper hygienic and cleansing techniques. This brings her to the attention of …

Investigating Biometrics Of Perimyotis Subflavus In Traditional And Nontraditional Hibernacula In The Southeastern United States As It Relates To Susceptibility To White-Nose Syndrome., Makayla Ferrari

Master of Science in Integrative Biology Theses

Perimyotis subflavus, or tricolored bat, populations have declined significantly since the emergence of white-nose syndrome (WNS) and has been proposed for listing as “endangered” under the United States Endangered Species Act. Traditionally, bats use caves as hibernacula, but as anthropogenic impacts have increased so has the use of manmade structures like culverts and bridges for roosting by several bat species. The internal environment of these anthropogenic structures is influenced by external temperature and humidity differently than caves and may influence P. subflavus winter activity, and thus susceptibility to WNS. One of the most significant differences in P. subflavus roosting behavior …

Pyrvinium Pamoate: Past, Present, And Future As An Anti-Cancer Drug, Christopher W Schultz, Avinoam Nevler

Department of Surgery Faculty Papers

Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some polyaminopyrimidines and mitochondrial-targeting peptoids, has been linked with mitochondrial localization and targeting. Over the past two decades, increasing evidence has emerged showing pyrvinium to be a strong anti-cancer molecule in various human cancers in vitro and in vivo. This efficacy against cancers has been attributed to diverse mechanisms of action, with the weight of evidence supporting the inhibition of mitochondrial function, the WNT pathway, and cancer stem cell renewal. …

The Cholera-Fiend: Cheap Fiction, Medical Professionals, And Entertainment, Sariah Fales Harrington

Theses and Dissertations

First published in 1849, Charles Averill’s The Cholera-Fiend follows three villains as they attempt to artificially propagate cholera for their own villainous purposes in New York City. Gumbo, a Black servant to one of the villains, is meant to be the humorous relief in the text, but Gumbo experiences a calculated dehumanization from human to disabled, which causes him to be more at-risk for a health crisis—such as a tapeworm or cholera—than his white counterparts. Through analyzing the genre of cheap fiction, the views of medical professionals towards Black bodies, and other ways Black bodies were used as entertainment, I …

Benefit-Cost Analysis Of Green Infrastructure Investments: Application To Small Urban Projects In Hinesville, Ga, Craig Landry, J Scott Pippin, Mohammadreza Zarei

Journal of Ocean and Coastal Economics

Small scale urban green infrastructure projects can provide local ecological services that should be accounted for in project assessment. Benefits assessment can be expensive and time consuming; benefit transfer provides an economical alternative, but the quality of the analysis depends upon available data. A best-case scenario for many applications of benefit transfer is to utilize a conforming meta-analysis. In this paper, we use the meta-analysis of Bockarjova, et al. (2020) to predict ecological benefits of small scale urban green infrastructure investments in Hinesville, GA. In doing so, we implement a censoring procedure on the benefit transfer function to permit analysis …

Consumer Boycotts In The Time Of War Crisis: An Efficient Citizenship Strategy Or A Temporary Spurt Of Solidarity, Jolanta Zralek

Journal of Vincentian Social Action

By drawing from the theory of consumer citizenship, collective activism, and consumer boycotts, this article strives to understand the nature of the current calls for consumer resistance and the following consumers’ actions that resulted from the Russian invasion of Ukraine. In particular, by utilizing Friedman’s (1991) taxonomy of boycotts, we aimed to identify the character, motives, and tools of ongoing boycotts and thus estimated their actual and probable effectiveness. The main research questions in this paper concern what type of consumer boycotts we currently observe, what the aims and motives are of current boycotting, and whether the noticed boycotting attempts …

Volume 5, Issue 2 (2022) Migration, Community, And Environment During A Pandemic

International Journal on Responsibility

No abstract provided.

Remote Desktop Sharing With Multiple Users With High Quality Video And Audio Throughputs, Hp Inc

Defensive Publications Series

A system that enables multiple remote users to simultaneously connect to a desktop is disclosed. The desktop can be hosted on a remote physical or virtual machine. Audio and video content from the remote desktop is securely transferred over the network to all connected users. The audio and video qualities are adjusted dynamically based on the network performance of all the connections.

A Model For Equity-Oriented Prek-12 Engineering, Christine M. Cunningham, Gregory J. Kelly

Journal of Pre-College Engineering Education Research (J-PEER)

In this paper, we address the societally important issue of developing a more equitable approach to preK-12 engineering education. Our primary emphasis is on K-8 grades—a time when first impressions of engineering may be developed. Calls for increased participation by all students, including those who have been historically marginalized, motivate the need for theoretically grounded ways of developing and assessing educational programs. This paper draws from sociocultural learning theory and applies four theoretical and empirical analyses to derive design principles for equity that can inform curriculum, instruction, and assessment of preK-12 engineering education programs. We present a model for equity-oriented …

Liberatory School Counseling Practices To Promote Freedom Dreaming For Black Youth, Renae D. Mayes, Natalie E. Edirmanasinghe, Kara Ieva, Ahmad R. W. Washington

College of Education Departmental Research

The American School Counseling Association calls for professional school counselors to support the holistic development and success of all students. However, the field of school counseling is riddled with practices that have harmed and dehumanized Black students. For example, school counselors engage in practices (e.g., social–emotional learning and vocational guidance), which work to reinforce white supremacy and dehumanize Black students. Further, school counselors may also contribute to the ways that the basic and unique needs of Black students are overlooked, leading to the continued systemic adultification of Black students. What is needed is a radical imagination of school counseling, which …

Forming A "Brain Print:" Using Cognitive Neuroscience And Brain Imaging As An Objective Measure Of Criminal Insanity, Christos D. Strubakos

Lincoln Memorial University Law Review Archive

Fiction popularized the concept of criminal insanity. Yet, despite its popularity in the virtual world, it is rarely used in real life. The chief reason for this is that mental disorders that may inhibit a defendant's ability to form reasonable cognitive representations of reality often do not impact his ability to form a key element of a crime: the requisite mental state. Thus, the legal definition of criminal insanity refers to a mental defect that affects a defendant's ability to appreciate her actions at the time of the crime or to understand her actions are wrong. Further complicating matters is …

Exploring The Role Of Dieting Style In Nutritional And Psychological Health Among College Women, Hayley L. Vanderjagt

Psychology ETDs

The current study aimed to profile styles of eating among dieting and non-dieting college-aged women, and to explore the extent to which dieting attitudes were associated with both nutritionally healthy eating and psychological well-being. A latent profile analysis was conducted using indicators of self-reported intuitive eating, binge eating, and two psychometric measures of dietary restraint; various measures of eating restraint were utilized to potentially capture distinct characteristics of dieting, such as self-discipline and disinhibition (Polivy et al., 2020; Stice et al., 2010). Four distinct probabilistic profiles emerged, indicating that individuals within the study population could be meaningfully categorized as Intuitive …

Dude, Where's My House: The Interaction Between The Takings Clause, The Police Power, The Militarization Of Law Enforcement, And The Innocent Third-Party Property Owner, Tristan Reagan

Tulsa Law Review

No abstract provided.

Back To The Roots: Black Veganism, Kiara R. Thomas

Capstones

Only 3% of Americans in general, but 8% of Black Americans are strict vegan or vegetarian. Whether it’s to reduce animal cruelty, manage a chronic illness, or connect with their heritage and build a social movement, Black people are embracing plant-based diets. https://kiarathomas429.github.io/portfolio/

Lipid-Nanoparticle-Mediated Delivery Of Docetaxel Prodrug For Exploiting Full Potential Of Gold Nanoparticles In The Treatment Of Pancreatic Cancer, Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C Tam, Sunil Krishnan, Devika B Chithrani

Faculty, Staff and Student Publications

Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, we explored the effect of a DTX prodrug encapsulated in lipid nanoparticles (LNP_DTX-P) on GNP uptake in pancreatic cancer models in vitro and in vivo. For the in vitro experiment, a pancreatic cancer cell line, MIA PaCa-2, was cultured and dosed with 1 nM GNPs and 45 nM free DTX or an equivalent dose of LNP_DTX-P. For the in vivo experiment, MIA PaCa-2 cells were implanted subcutaneously …

System Of Language Learning With Augmented Reality, Sara Ashley Smith, Maria Soledad Carlo, Sanghoon Park, Howard Kaplan

USF Patents

Education curricula materials include encoded indicia such as a QR code that contains information related to identifying requested augmented reality image data from a server over a network. By scanning the QR code, a computer uses its decoding software to create a data set for transmitting to the server. The data set may include an identifier for selected augmented reality image data associated with the user's curriculum, information about the curriculum at issue, the academic level of the user, and any other data necessary to ensure that the most appropriate augmented reality image data is transmitted back to the computer. …

Stat3 Gain-Of-Function Mutations Connect Leukemia With Autoimmune Disease By Pathological Nkg2dhi Cd8+ T Cell Dysregulation And Accumulation, Etienne Masle-Farquhar, Megan A Cooper, Tiphanie P Vogel, Et Al.

2020-Current year OA Pubs

The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8

Biofilm Characterization And The Potential Role Of Edna In Horizontal Gene Transfer In Hospital And Meat Isolates Of Staphylococcus Aureus And Their Biofilms, Ashley Lynne Ball

Theses and Dissertations

Staphylococcus aureus is a pathogen responsible for a wide variety of life-threatening diseases such as bacteremia, endocarditis, and pneumoniae. S. aureus has been a major concern in recent years due to the rampant spread of antibiotic resistance. The ability of S. aureus to form biofilms aids in the spread of antibiotic resistance as biofilms are a known hotspot for horizontal gene transfer. Biofilms also protect cells from host immune responses and antibiotics, making these infections very difficult to treat. The matrix of S. aureus biofilms can be made of polysaccharides, protein, and DNA. In these studies, we sought to elucidate …

Sugar Freed, Sarah Gaygen

Theses

Sugar Freed is a 2D digitally animated short film about a little girl named Molly, who gets fed up with her mother, a dentist, and ends up in a candy world ruled by evil gummy bears. Sugar Freed’s message evolved over time from a simple warning against sugar, to a child gaining an understanding of why her mother’s lessons are necessary, stemming from parts of my own childhood. The purpose of this film was to see if I could find the right balance between time management and quality control to produce an animated short that was well over four-minutes long, …

Black Cosplayers Push For Proper Dark-Skinned Character Representation In Media, Taylor K. Johnson

Capstones

As cosplay continues to rise in popularity at comic conventions, anime conventions and on social media, Black cosplayers push for media companies to invest in adding more dark-skinned characters in their shows and games.

Scientists And Activists Work To Save The Planet, Myriam G. Vidal Valero

Capstones

Climate change and human intervention in nature are affecting people, ecosystems and ways of living all over the world. This portfolio of environmental pieces showcases the dire consequences of not addressing these issues, how solutions can be reached and the challenges facing those who try to change things.

Representation In Animation — Bringing Diversity Behind The Screen, Elizabeth Short

Capstones

Animation is an extremely popular form of media, particularly for children who grow up with the influence of cartoon television shows and films. As long-standing discussions on representation in media expand, the evolution of diversity in animated characters grows as well. Examining the history of animation as an art form and its changes over the years is important, but it is also essential to ask — does representation on-screen match representation behind the scenes? If not, how does that change?

https://medium.com/@liz.short31/representation-in-animation-bringing-diversity-behind-the-screen-3033f06632b6

The Role Of Chitinase A In Mastitis-Associated Escherichia Coli Pathogenesis, Weston D. Hutchison

Theses and Dissertations

Bovine mastitis is a common disease among dairy cattle characterized by the inflammation of the udders and loss of milk production. Mastitis-associated Escherichia coli (MAEC) are frequent causes of the disease, but the features that distinguish them from other E. coli strains remain enigmatic. MAEC infections can range from sub-clinical to severe, acute cases that can be fatal. Historically, the severity of mastitis has been attributed to host factors but more recently, a few bacterial genes have been shown to contribute to virulence in mastitis infections. In a large-scale genomic analysis of >100 MAEC isolates the gene for Chitinase A …

Decreasing Trash In Local Creeks: A Program Evaluation Of The City Of San Jose’S Direct Discharge Trash Control Program, Lakeisha Bryant

Master's Projects

The entire San Francisco Bay was once a navigable waterway in the 1850s during the Gold Rush era. Large amounts of sediment from upstream erosion and mining flowed to the bay resulting in the downsizing of the bay’s square miles (Environmental Protection Agency, 2022). As a result of intense development on the bay shores and adjacent lands, the bay faces several challenges that affect its water quality and threatens aquatic ecosystems. Pesticides, mercury, metals, and pathogens are just a few substances in the bay that cause unhealthy conditions for aquatic life and threaten human health. California’s Water Resources Control Board …

Defining Cellular Population Dynamics At Single-Cell Resolution During Prostate Cancer Progression, Alexandre A Germanos, Sonali Arora, Ye Zheng, Erica T Goddard, Ilsa M Coleman, Anson T Ku, Scott Wilkinson, Hanbing Song, Nicholas J Brady, Robert A Amezquita, Michael Zager, Annalysa Long, Yu Chi Yang, Jason H Bielas, Raphael Gottardo, David S Rickman, Franklin W Huang, Cyrus M Ghajar, Peter S Nelson, Adam G Sowalsky, Manu Setty, Andrew C Hsieh

Faculty, Staff and Student Publications

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution from disease onset to the development of androgen independence in an in vivo murine model. We observe an expansion of a castration-resistant intermediate luminal cell type that correlates with treatment resistance and poor prognosis in human patients. Moreover, transformed epithelial cells and associated fibroblasts create a microenvironment conducive to pro-tumorigenic immune infiltration, which is partially androgen responsive. Androgen-independent prostate cancer leads to significant diversification of …

Mir21 Modulates The Hippo Signaling Pathway Via Interference With Pp2a Bβ To Inhibit Trophoblast Invasion And Cause Preeclampsia, Mingyu Hu, Yangxi Zheng, Jiujiang Liao, Li Wen, Juan Cheng, Jiayu Huang, Biao Huang, Li Lin, Yao Long, Yue Wu, Xuan Ye, Yong Fu, Hongbo Qi, Philip N Baker, Chao Tong

Faculty, Staff and Student Publications

Preeclampsia (PE) is a pregnancy-specific disorder attributed to deficient extravillous trophoblast (EVT) invasion into the uterus, but the mechanism of EVT invasion remains unclear. In this study, we found significantly elevated expression of microRNA 21 (miR21), which negatively regulates trophoblast invasion and migration, in preeclamptic placentae. Whole-genome RNA sequencing revealed that PPP2R2B, which encodes PP2A Bβ, and the Hippo pathway are downstream targets of miR21. The effects of miR21 on trophoblast mobility were abolished in LATS1T1079A/S909A and YAP-5SA mutants. Moreover, we found that PP2A Bβ dephosphorylates LATS1 via direct protein-protein interactions and thus modulates the phosphorylation and subcellular distribution …

Egfr-Phosphorylated Gdh1 Harmonizes With Rsk2 To Drive Creb Activation And Tumor Metastasis In Egfr-Activated Lung Cancer, Jihoon Kang, Jaemoo Chun, Jung Seok Hwang, Chaoyun Pan, Jie Li, Austin C Boese, Isabelle Young, Courteney M Malin, Yibin Kang, Don L Gibbons, Gabriel Sica, Haian Fu, Suresh S Ramalingam, Lingtao Jin, Sumin Kang

Faculty, Staff and Student Publications

The cancer metastasis process involves dysregulated oncogenic kinase signaling, but how this orchestrates metabolic networks and signal cascades to promote metastasis is largely unclear. Here we report that inhibition of glutamate dehydrogenase 1 (GDH1) and ribosomal S6 kinase 2 (RSK2) synergistically attenuates cell invasion, anoikis resistance, and immune escape in lung cancer and more evidently in tumors harboring epidermal growth factor receptor (EGFR)-activating or EGFR inhibitor-resistant mutations. Mechanistically, GDH1 is activated by EGFR through phosphorylation at tyrosine 135 and, together with RSK2, enhances the cAMP response element-binding protein (CREB) activity via CaMKIV signaling, thereby promoting metastasis. Co-targeting RSK2 and GDH1 …

Servant-Leaders As Co-Laborers: A Field Philosophy Model, Jae Webb

International Journal of Servant-Leadership

In 2013, Professor R. Edward Freeman joked about his father’s sarcastic witticism in response to his choice of career. The joke is not that philosophy is a feckless art, but rather that its modern practice has been relegated to the realm of theory, with incredibly salient subject matter but a practice that is seemingly ineffectual in the everyday world. Justice is one such area of interest for philosophers; however, abstract theoretical or philosophical justice, especially in relation to environmental resources and in consideration of environmental relationships, is increasingly meaningless for contemporary society. Environmental injustice is lived and experienced, it is …

A Conceptual Model For Community-Building Through Servant-Leadership At Different Organizational Levels, Kasey N. Morris, Kevin J. Hurt

International Journal of Servant-Leadership

Community lays the foundation for a strong, flourishing society. It interconnects individuals, organizations, and societies by encouraging shared vision and mutual respect among all parties involved. The term community has two primary uses: (1) geographic and (2) relational, where geographic describes community as a physical location while relational refers to a community in terms of its psychological closeness to and quality of relationships with others (Gusfield, 1975). McMillan and Chavis (1986) build on the relational concept, stating that a “sense of community is a feeling that members have of belonging, a feeling that members matter to one another and to …

Psychoactive Space: Glimpses Of The Unknown, Mathew Emmett

School of Art, Design and Architecture

No abstract provided.