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2022

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Human Nk Cells Confer Protection Against Hiv-1 Infection In Humanized Mice, Can M. Sungur, Qiankun Wang, Ayşe N. Ozantürk, Hongbo Gao, Aaron J. Schmitz, Marina Cella, Wayne M. Yokoyama, Liang Shan Dec 2022

Human Nk Cells Confer Protection Against Hiv-1 Infection In Humanized Mice, Can M. Sungur, Qiankun Wang, Ayşe N. Ozantürk, Hongbo Gao, Aaron J. Schmitz, Marina Cella, Wayne M. Yokoyama, Liang Shan

2020-Current year OA Pubs

The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While humanized mouse models potentially could be used to directly evaluate human NK cell responses during HIV-1 infection, improved functional development of human NK cells in these hosts is needed. Here, we report the humanized MISTRG-6-15 mouse model, in which NK cells were quick to expand and exhibit degranulation, cytotoxicity, and proinflammatory cytokine production in nonlymphoid organs upon HIV-1 infection but had reduced functionality in lymphoid organs. Although HIV-1 infection induced functional impairment of NK cells, antiretroviral therapy reinvigorated NK cells in response to HIV-1 rebound …

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Entering Without Breaking: Challenges And Strategies Of The Qualitative Criminologist Investigating Carceral Spaces, Anaïs Tschanz Dec 2022

Entering Without Breaking: Challenges And Strategies Of The Qualitative Criminologist Investigating Carceral Spaces, Anaïs Tschanz

Qualitative Criminology (QC)

"Although qualitative methodology courses in criminology make it possible to gain theoretical and practical training in the collection, analysis and interpretation of data gathered using qualitative tools, these more rarely help address more targeted questions and concerns. Without making any claim to offer definitive solutions beyond the status of “tip,” this article attempts to tackle “things they don't really teach you how to handle in your qualitative methodology class,” concerning research in a carceral environment. By characterising carceral space as an opaque, all-encompassing environment pervaded by spatiotemporal constraints, it describes strategies that can be implemented in the face of organisational, …

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National Security Concept Of Mongolia, Mongolian Ministry Of Foreign Affairs Dec 2022

National Security Concept Of Mongolia, Mongolian Ministry Of Foreign Affairs

Documents

No abstract provided.

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Determination Of The Residues Of 15 Kinds Of Benzodiazepine Sedatives In Aquatic Products By Liquid Chromatography Tandem Mass Spectrometry, Zhang Qiu-Yun, Yang Hong-Sheng, Tan Xiu-Hui, Zhu Xiao-Hua, Chen Feng-Wei, Chen Hui-Min Dec 2022

Determination Of The Residues Of 15 Kinds Of Benzodiazepine Sedatives In Aquatic Products By Liquid Chromatography Tandem Mass Spectrometry, Zhang Qiu-Yun, Yang Hong-Sheng, Tan Xiu-Hui, Zhu Xiao-Hua, Chen Feng-Wei, Chen Hui-Min

Food and Machinery

Objective: This study aimed to eslablish a method for the determination of 15 benzodiazepine sedatives in aquatic products by liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Methods: The sample was extracted with acetonitrile solvent, and the extract was purified by solid phase extraction (Oasis PRIME HLB) column. After concentration, the mobile phase was used to determine the volume. The mobile phase consisted of 1% formic acid aqueous solution and acetonitrile solvent. The method was performed in multiple reaction monitoring (MRM) mode and quantified by internal standard method. Results: The results showed that the linear range of 15 sedatives …

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Anonymity With Intent? 'We Lordis Hes Chosin A Chiftane Mervellus', Janet Hadley Williams Dec 2022

Anonymity With Intent? 'We Lordis Hes Chosin A Chiftane Mervellus', Janet Hadley Williams

Studies in Scottish Literature

This paper considers an anonymous, untitled poem, opening “We lordis hes chosin a chiftane mervellus,” known in only one text, in the Bannatyne Manuscript (fols 78v–79r), among “ ballatis full of wisdome and moralitie.” Its enigmatic nature and place among the moral ‘ballatis’ have gone largely unstudied. Focus on the author’s identity (with William Dunbar seen as likely) has excluded the interesting question of possible deliberate anonymity. The poet’s Franco-Scots linguistic agility, and careful play of political interests (Scottish, French and English) are striking, the more so because, unusually, “We lordis” can be dated with some …

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Managing Tennessee's Public Waterways For Recreation, Balancing Access, Safety, And Protection Of Natural Resources, Tennessee. Advisory Commission On Intergovernmental Relations. Dec 2022

Managing Tennessee's Public Waterways For Recreation, Balancing Access, Safety, And Protection Of Natural Resources, Tennessee. Advisory Commission On Intergovernmental Relations.

Miscellaneous Reports

No abstract provided.

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The Montclarion, December 15, 2022, The Montclarion Dec 2022

The Montclarion, December 15, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

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Evaluating Evidence Of Episodic Tendencies During Semantic Fluency, Rebecca Anne Wilder Dec 2022

Evaluating Evidence Of Episodic Tendencies During Semantic Fluency, Rebecca Anne Wilder

Theses - ALL

While semantic organization has been widely observed in episodic memory tasks, episodic organization has yet to be observed in the semantic fluency task, due to structural differences between test paradigms. Episodic memory effects require an opportunity for target information to first be learned and later retrieved. Semantic fluency tasks, which are designed to measure retrieval capacity for facts, are typically limited to a single test-phase format. In semantic fluency tasks, participants are presented with a semantic retrieval cues (i.e. category prompts) and asked to list as many items as they can think of that fit the classification. The repeated fluency …

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The United States Military’S Role In Maintaining National Security During The Height Of The “War On Drugs”, Sara Terrien Dec 2022

The United States Military’S Role In Maintaining National Security During The Height Of The “War On Drugs”, Sara Terrien

Washington Semester Program

This paper will seek to answer the question: What understanding of national security justified the use of the United States military in the “War on Drugs,” launched by the Reagan administration in 1982? A secondary question that this paper will investigate is whether the definition of “national security” that was used contributed to the protection of American lives and interests. The approach that this paper will take is that the understanding of national security as “defense of the homeland” justified the use of the United States military in the “War on Drugs.” Moreover, the involvement of the United States military …

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Insights Into The Biotechnology Potential Of Methanosarcina, Sean Carr, Nicole R. Buan Dec 2022

Insights Into The Biotechnology Potential Of Methanosarcina, Sean Carr, Nicole R. Buan

Department of Biochemistry: Faculty Publications

Methanogens are anaerobic archaea which conserve energy by producing methane. Found in nearly every anaerobic environment on earth, methanogens serve important roles in ecology as key organisms of the global carbon cycle, and in industry as a source of renewable biofuels. Environmentally, methanogenic archaea play an essential role in the reintroducing unavailable carbon to the carbon cycle by anaerobically converting low-energy, terminal metabolic degradation products such as one and two-carbon molecules into methane which then returns to the aerobic portion of the carbon cycle. In industry, methanogens are commonly used as an inexpensive source of renewable biofuels as well as …

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Traditional Beliefs, Practices, And Migration: A Risk To Malaria Transmission In Rural Nepal, Kr Awasthi, J Jancey, Aca Clements, Rk Sah, Et Al Dec 2022

Traditional Beliefs, Practices, And Migration: A Risk To Malaria Transmission In Rural Nepal, Kr Awasthi, J Jancey, Aca Clements, Rk Sah, Et Al

Peninsula Medical School

The study aimed to explore sociocultural factors influencing the risk of malaria and practices and beliefs towards malaria prevention, transmission and treatment in a remote village in Khatyad Rural Municipality (KRM) of Nepal. A sequential exploratory mixed methods approach was used. Qualitative data were collected through 25 one-on-one, in-depth interviews followed by a face-to-face household survey (n = 218) among people from a village in KRM believed to have a high risk of malaria. Traditional practices such as Chhaupadi requiring the seclusion of women during menstruation and post-partum, transhumance, and reliance on traditional healers for the management of malaria were …

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Fairy Tale By Stephen King, Phillip Fitzsimmons Dec 2022

Fairy Tale By Stephen King, Phillip Fitzsimmons

Faculty Articles & Research

Book review of Fairy Tale by Stephen King, reviewed by Phillip Fitzsimmons.

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“High Fantasy Track.” Dragon Con, Atlanta, Ga. September 1-5, 2022. Reviewed By Tim Lenz, Tim Lenz Dec 2022

“High Fantasy Track.” Dragon Con, Atlanta, Ga. September 1-5, 2022. Reviewed By Tim Lenz, Tim Lenz

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

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Wildfire Smoke Exposure In California: Public Health Impacts And Mitigation Strategies, Jiaxi Hou Dec 2022

Wildfire Smoke Exposure In California: Public Health Impacts And Mitigation Strategies, Jiaxi Hou

Master's Projects and Capstones

Climate change projections show that wildfires are becoming more severe and frequent over the next few decades. In California, as a leader in environmental protection and resilience planning, there are still concerns about the impacts of wildfire. Several places such as Napa Valley, Los Angeles forests, and Yosemite National Park have been exposed to long-lasting wildfire damage. Wildfire smoke contains toxic pollutants such as particulate matter 2.5 (PM2.5) that can cause negative health impacts on the public. It has been proved that these public health impacts are cumulative, and wildfire PM2.5 can exacerbate pre-existing conditions. Therefore, there …

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Al-Munawun In The Holy Qur’An: A Pragmatic Linguistic Approach (Salsabil) As A Mode, Wathiq Galib Hashim Dec 2022

Al-Munawun In The Holy Qur’An: A Pragmatic Linguistic Approach (Salsabil) As A Mode, Wathiq Galib Hashim

Alustath Journal for Human and Social Sciences

The multiplicity of facets and possibilities in the analysis of a specific linguistic issue, or a specific grammatical issue, is a familiar matter that is common in the study of Arabic, indicating the occurrence of disagreement in opinions at the level of a single issue, as occurred in the name Al-Manun (Salsabil) mentioned in the Almighty’s saying: “An eye in it is called Salsabil.” ( [Al-Insan: 18] who was chosen by the research as his field, he saw in it what is sufficient to reveal this phenomenon in the sayings of the people of Arabic and the commentators, and the …

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Candles In Babylon: Denise Levertov's Spiritual Journey, Nadia Ali Ismael Dec 2022

Candles In Babylon: Denise Levertov's Spiritual Journey, Nadia Ali Ismael

Alustath Journal for Human and Social Sciences

Through all her work, Denise Levertov’s (1923-1997) penchant for describing religious issues is evident. Various religious images punctuate her work, an indication of either her deep conviction of the existence of a supreme deity, or just a mere description of the wonders of the metaphysical world. But even though her works are punctuated with these religious emblems, Candles of Babylon seems to have taken a new trajectory. There is an admission to the effect that she is on a spiritual odyssey; she gives a clear description of how she makes this journey. Like John Bunyan’s Pilgrims’ Progress (1678), she described …

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Working Paper No. 68, Variables Precipitating The Extermination Of The American Bison, Cameron Winterer Dec 2022

Working Paper No. 68, Variables Precipitating The Extermination Of The American Bison, Cameron Winterer

Working Papers in Economics

This inquiry seeks to establish that innovations in tanning technology advanced by Europeans in the late 19th century accelerated the destruction of the bison, and subsequently the downfall of bison-reliant indigenous groups of the Great Plains, especially. The North American bison is considered as a crucial natural resource in the plains region of North America. What this inquiry seeks to emphasize is that advancements in technology, coupled with a growing demand for bison hides, contributed to the demise of bison populations. Lastly, this inquiry seeks to examine the near extinction of the plains bison and some of the effects their …

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The Bidirectional Relationship Between The Circadian Clock And Alzheimer’S Disease, Patrick Sheehan Dec 2022

The Bidirectional Relationship Between The Circadian Clock And Alzheimer’S Disease, Patrick Sheehan

Arts & Sciences Graduate Student Theses and Dissertations

The circadian clock and inflammation have a well-described bidirectional relationship in the peripheral immune system: the circadian clock regulates inflammatory responses, but inflammation also impacts oscillatory gene transcription controlled by the clock. The purpose of this thesis work is to understand if manipulation of the circadian clock can impact Alzheimer’s disease pathology, and if pathology itself can alter the circadian clock and its outputs. Here, I show that astrocyte-specific disruption of the circadian clock via deletion of the clock gene Bmal1 surprisingly decreased intra-neuronal protein pathologies. Further investigation found that deletion of the circadian clock resulted in a transcriptomic profile …

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Understanding Individual Cells In Zebrafish Caudal Fin Regeneration (从单细胞视角理解斑马鱼尾鳍再生历程), Yiran Hou Dec 2022

Understanding Individual Cells In Zebrafish Caudal Fin Regeneration (从单细胞视角理解斑马鱼尾鳍再生历程), Yiran Hou

Arts & Sciences Graduate Student Theses and Dissertations

Humans are incapable of complex body structure regeneration. Understanding how other species retain the ability to regenerate can help us to find solutions for improving our regenerative capacities. The zebrafish is an organism that is capable of regenerating multiple organs in its body. Using zebrafish as a model organism, previous studies have identified key processes and illustrated the crucial cell types and genes for regeneration. In caudal fin specifically, blastema formation is a key predictor of successful regeneration. However, a comprehensive molecular understanding of cell type-specific contributions to this process is lacking. In this dissertation, I present our efforts toward …

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Uneasy Attachments: Postcolonial Anglophilia And Identity Formation In Twentieth-Century Anglophone Autobiographies, Anwesha Kundu Dec 2022

Uneasy Attachments: Postcolonial Anglophilia And Identity Formation In Twentieth-Century Anglophone Autobiographies, Anwesha Kundu

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation focuses on the impact of anglophilia on identity formation in the British empire. Since Britishness was an identity unavailable to non-white citizens of the empire, this attachment was necessarily unrequited. Analyzing works by Cornelia Sorabji, E.R. Braithwaite, V.S. Naipaul, and Tsitsi Dangarembga, I argue that the critical significance of anglophilia does not lie in the postcolonial subject’s success or failure in achieving a British-coded identity, but in the ways in which an affiliation to Britishness can be mobilized to accomplish a variety of personal, political, and social ends. I use a range of autobiographical literature—travel narratives, autobiographical novels, …

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Extensive Behavioral Phenotyping Of Williams Syndrome Locus Relevant Mouse Models To Assess Contributions Of Oxytocin And Gtf2ird1, Kayla Rose Nygaard Dec 2022

Extensive Behavioral Phenotyping Of Williams Syndrome Locus Relevant Mouse Models To Assess Contributions Of Oxytocin And Gtf2ird1, Kayla Rose Nygaard

Arts & Sciences Graduate Student Theses and Dissertations

The Williams Syndrome Critical Region (WSCR) at chromosome 7q11.23 provides a unique opportunity to untangle the relationship between genotype and phenotype in complex behaviors, from fear and anxiety to sociability and sensorimotor processing. Copy number variations (CNVs) in this region result in two syndromes, Williams Syndrome (WS) and Duplication 7q11.23 Syndrome (Dup7), which display phenotypes that may align, indicating a common disruption of a system, or diverge, reflecting an underlying gene dosage-dependent effect. While case studies of atypical deletions resulting in WS have implicated telomeric genes Gtf2ird1 and Gtf2i in the cognitive and behavioral profiles of WS, proving causation requires …

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Characterizing Complex Affective Processing Across Age And In Relation To Social Anxiety Symptoms, M. Catalina Camacho Dec 2022

Characterizing Complex Affective Processing Across Age And In Relation To Social Anxiety Symptoms, M. Catalina Camacho

Arts & Sciences Graduate Student Theses and Dissertations

Humans require a shared understanding of others’ emotions for adaptive social functioning. For instance, if someone tells a joke and another person laughs, we assume the laughing person was happy because we have a shared concept for such positive interactions. Children develop and refine these concepts as they grow up, but the underlying neural processing that supports this development is unknown. Identifying the neurodevelopment underlying emotion processing could provide important insight to emotional disorders. For example, social anxiety is associated differences in the detection and interpretation of negative or neutral emotional cues, but the underlying neurodevelopment of this behavior is …

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The Role Of The Neurodevelopmental Disorder Gene Myt1l In Mammalian Brain Development, Jiayang Chen Dec 2022

The Role Of The Neurodevelopmental Disorder Gene Myt1l In Mammalian Brain Development, Jiayang Chen

Arts & Sciences Graduate Student Theses and Dissertations

Recent human genetic studies have associated mutations in a gene called Myelin Transcription Factor 1 Like (MYT1L) with neurodevelopmental disorders (NDDs). Patients with MYT1L loss of function (LoF) mutations (MYT1L Syndrome patients) demonstrate shared symptoms such as microcephaly, attention deficit and hyperactivity disorder (ADHD), and obesity. Despite prior studies showing MYT1L overexpression facilitates neuronal differentiation in vitro, its functions in vivo, especially in the mammalian brain, and how its mutation leads to human disease pathology remains poorly understood. Here, I established the first mouse model of MYT1L Syndrome mimicking a patient specific LoF mutation. I found mice with Myt1l heterozygous …

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Connections Between Mechanosensitive Ion Channel Msl10 And Er-Plasma Membrane Contact Sites, Jennette Marie Codjoe Dec 2022

Connections Between Mechanosensitive Ion Channel Msl10 And Er-Plasma Membrane Contact Sites, Jennette Marie Codjoe

Arts & Sciences Graduate Student Theses and Dissertations

Mechanosensitive (MS) ion channels are an evolutionarily conserved way for cells to sense mechanical forces and transduce them into ionic signals. A plasma membrane-localized MS channel from Arabidopsis thaliana, MscS-Like (MSL)10, senses cell swelling and initiates a signaling cascade that triggers programmed cell death. Whereas the channel properties of MSL10 have been well studied, how MSL10 signals remains largely unknown. I worked collaboratively to show that important lesions for cell death signaling in the cytosolic N- and C-terminal domains of MSL10 interact genetically. I also helped show that ionic flux through MSL10 is dispensable for signaling, which suggested that MSL10 …

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Circadian Circuitry And Glioblastoma: Interactions With Behavior, Carcinogenesis, And Clinical Practice., Anna R. Damato Dec 2022

Circadian Circuitry And Glioblastoma: Interactions With Behavior, Carcinogenesis, And Clinical Practice., Anna R. Damato

Arts & Sciences Graduate Student Theses and Dissertations

Glioblastoma (GBM) is the most common primary adult brain tumor diagnosed, with a 15-month prognosis using current standard of care treatment which includes chemotherapy with temozolomide (Temodar, TMZ). Chronotherapy, the practice of considering time of day in treating a disease, has been shown to improve outcome in several cancers, but had not been applied to GBM. Previous work in the lab on a cultured murine mesenchymal GBM cell line showed a time-of-day dependent maximum in sensitivity to TMZ corresponding with the daily peak of Bmal1 and trough of Per2 expression, two core clock genes. Based on this finding, we sought …

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Reassessing The History Of The Poverty Point Phenomenon: A Case Study From The Jaketown Site, Mississippi, Usa, Seth Bradley Grooms Dec 2022

Reassessing The History Of The Poverty Point Phenomenon: A Case Study From The Jaketown Site, Mississippi, Usa, Seth Bradley Grooms

Arts & Sciences Graduate Student Theses and Dissertations

Towards the end of the Late Archaic period (ca. 4800-3000 cal BP), between 3,600 and 3,300 years ago, Native Americans engineered a colossal earthwork complex that covers approximately 200 hectares in northeast Louisiana. Today, it is a UNESCO World Heritage site known as Poverty Point and the namesake for a material culture pattern documented to varying degrees at sites throughout the Lower Mississippi Valley (LMV). However, the nature of interactions between these sites and the type site is poorly understood. The people who constructed the Poverty Point site lived on wild food resources. They hunted, fished, and gathered food from …

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Host Development And Microbiota Influences On Norovirus Infection, Elizabeth Alexandra Kennedy Dec 2022

Host Development And Microbiota Influences On Norovirus Infection, Elizabeth Alexandra Kennedy

Arts & Sciences Graduate Student Theses and Dissertations

The mammalian gut is a complex organ which changes over the course of development and is influenced by the presence of a dense community of gut-resident microbes. Enteric viruses infect the gastrointestinal tract in the context of the commensal microbiota and host immunity. Here, we dissect the influence of host developmental stage and the gut microbiota in norovirus infection. From this work, we determine that murine norovirus (MNoV) infection in early life is restricted by an absence of the target MNoV cell tuft cells and intact interferon (IFN) signaling. However, viral inoculum taken up by non-specific endocytosis in the neonatal …

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Functionalized Plasmonic Nanostructures For Ultrasensitive Single Cell Analysis, Priya Rathi Dec 2022

Functionalized Plasmonic Nanostructures For Ultrasensitive Single Cell Analysis, Priya Rathi

Arts & Sciences Graduate Student Theses and Dissertations

Ultrasensitive detection and quantification of soluble, secreted and cell surface-bound proteins is critical for advancing our understanding of cellular systems, enabling effective drug development, novel therapies, and bio-diagnostics. However, exiting technologies are largely limited by their sensitivity, making the detection and quantification of low-abundant proteins extremely challenging. This forms a major barrier in various fields of biology and biomedical sciences. In this work, we introduce novel cellular analysis methodologies based on plasmon-enhanced fluorescence for analyzing cell structure and probing surface and secreted proteins from cells. In the first part, we introduce plasmon-enhanced expansion microscopy and demonstrate the effectiveness of employing …

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Modernism As Public Art: Reawakening The Social Agency Of Abstract Public Sculpture, 1950–1980, Tola Porter Dec 2022

Modernism As Public Art: Reawakening The Social Agency Of Abstract Public Sculpture, 1950–1980, Tola Porter

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation presents a critical reassessment of postwar modern public sculpture and offers a framework for both the reevaluation and reawakening of these significant, inherited public images. Between 1950 and 1980, as a result of new national policies, the United Kingdom and the United States experienced a boom in public sculpture. That phenomenon was augmented by architectural modernism, whose stark buildings called for the addition of sculpture. The growing prestige of abstract art made it a popular choice for architects and commissioners, who sought to leverage the cachet of contemporary artists. For both private sector architects and public sector patrons, …

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Roles Of Behavioral Novelty And Organismal Energetics In The Evolution Of Extreme Encephalization, Erika Laurie Schumacher Dec 2022

Roles Of Behavioral Novelty And Organismal Energetics In The Evolution Of Extreme Encephalization, Erika Laurie Schumacher

Arts & Sciences Graduate Student Theses and Dissertations

Brains and their component brain regions vary widely in size and structure across vertebrates. However, extreme increases in total brain size relative to body size (extreme encephalization) and increases in specific major brain region sizes independent of other brain regions (mosaic brain evolution) are relatively rare. There are several hypotheses as to why, but the energetic cost of increased brain tissue and the regional interconnectedness in both brain development and function likely constrain how brains are able to change in response to selection. In this dissertation, I sought to address both how behavioral novelty relates to evolutionary changes in brain …

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