Digital Commons Network^™

Commercial Space Companies: Lawmakers Of 21st Century New Space, Hongxi Wang

Journal of Space Law

No abstract provided.

Water Insecurity And Gender-Based Violence: A Global Review Of The Evidence, Paula S. Tallman, Shalean Collins, Gabriela Salmon-Mulanovich, Binahayati Rusyidi, Aman Kothadia, Stroma Cole

Anthropology: Faculty Publications and Other Works

We reviewed the existing literature documenting the association between water insecurity and gender-based violence to (1) describe the characteristics and contexts of available studies, and (2) identify and classify documented gender-based violence across domains of water insecurity (access, affordability, adequacy, reliability, and safety). 18 peer-reviewed articles mentioned associations between water insecurity and gender-based violence. All studies were conducted in sub-Saharan Africa and South Asia and were published in English. The most common manifestation of the relationship between water insecurity and gender-based violence was an increased risk of sexual and physical violence for women who walked long distances to access water. …

The Impact Of Information-Seeking Self-Efficacy And Online Learning Self-Efficacy On Students’ Performance Proficiency, Yingqi Tang, Hungwei Tseng, Xingyi Tang

Research, Publications & Creative Work

This study surveyed 359 online undergraduate and graduate students regarding their information-seeking self-efficacy, online learning self-efficacy, and performance proficiency. A mediation model was conducted to examine the direct effect of students' online learning self-efficacy on their performance proficiency and the mediation effect of information-seeking self-efficacy. Multivariate correlational analysis showed that all three variables significantly correlated. Of the three variables, online learning self-efficacy has the strongest correlation to performance proficiency, while the variable with the least amount of correlation is between online-learning and information-seeking efficacies. Moreover, a significant regression equation showed that students' average performance proficiency increased by 0.359 for each …

Daily And Annual Weight Changes In Inca Doves, Allan J. Mueller

North American Bird Bander

No abstract provided.

Site Fidelity In Seven Passerines In Southern California, Walter H. Sakai

North American Bird Bander

No abstract provided.

An Upside-Down Primary In A Sharp-Shinned Hawk, Daniel E. Erickson

North American Bird Bander

No abstract provided.

Atlantic Flyway Review Fall 2019 Compiled By Aaron Given, Aaron Given

North American Bird Bander

No abstract provided.

Front Matter, North American Bird Bander

North American Bird Bander

No abstract provided.

Development Of A Novel Pharmacophore Model To Screen Specific Inhibitors For The Serine-Threonine Protein Phosphatase Calcineurin, Abhisek Mukherjee, Karina Cuanalo-Contreras, Abha Sood, Claudio Soto

Faculty, Staff and Student Publications

Calcineurin (CaN) is a calcium/calmodulin-dependent serine/threonine phosphatase with a crucial role in cellular homeostasis. It is also the target of the Food and Drug Administration (FDA) approved immunosuppressant drugs FK506 and cyclosporine A. Recent work from our group and others indicated that an uncontrolled increase in CaN activity causes synaptic dysfunction and neuronal death in various models of neurodegenerative diseases associated with calcium dysregulation. Furthermore, pharmacological normalization of CaN activity can prevent disease progression in animal models. However, none of the FDA-approved CaN inhibitors bind CaN directly, leading to adverse side effects. The development of direct CaN inhibitors is required …

Jove Videos For Science Education And Research — Now Available, Joanne Romano

TMC Library Newsletter (2015-)

The Texas Medical Center Library now subscribes to all JoVE videos for both Research and Education. JoVE’s 15,000+ instructional videos combine high-impact animations with real-life experimentation to help accelerate learning and allow you to refresh skill sets independently. Content can be accessed 24/7 and translations are included.

Acid Mine Drainage In The Shamokin Creek Watershed: A Spatial Analysis Of Economic And Environmental Consequences Of Coal Mining, Ben Shimer

Student Project Reports

No abstract provided.

A Convolutional Neural Network For Detecting Covid-19 From Chest X-Ray Images, Basma Wael Abdullah, Hanaa Mohsin

Iraqi Journal of Computers, Communications, Control and Systems Engineering

since the global pandemic of COVID-19 has spread out, the use of Artificial Intelligence to analyze Chest X-Ray (CXR) image for COVID-19 diagnosis and patient treatment is becoming more important. This research hypothesized that using COVID19 radiographic changes in the X-Ray images. Artificial Intelligence (AI) systems may extract certain graphical elements regarding COVID-19 and offer a clinical diagnosis ahead of pathogenic test; therefore, saving vital time for disease prevention. Employing 2614 CXR radiographs from Kaggle data collection of verified COVID-19 cases and healthy persons, a new ConVolutional Neural Network (CNN) model that is inspired by the Xception architecture was presented …

Meerkat Clan-Based Feature Selection In Random Forest Algorithm For Iot Intrusion Detection, Adil Yousef Hussein, Ahmed T.

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Hackers can conduct more destructive cyber-attacks thanks to the rapid spread of Internet of Things (IoT) devices, posing significant security risks for users. Through a malicious process, the attacker intended to exhaust the capital of the target IoT network. Researchers and company owners are concerned about the reliability of IoT networks, which is taken into account because it has a significant impact on the delivery of facilities provided by IoT systems and the security of user groups. The intrusion prevention system ensures that the network is protected by detecting malicious activity. In this paper, the focus is on predicting attacks …

Revisiting Sex Differences In The Acquisition And Extinction Of Threat Conditioning In Humans, Zhenfu Wen, Jamie Fried, Edward F Pace-Schott, Sara W Lazar, Mohammed R Milad

Faculty, Staff and Student Publications

Findings pertaining to sex differences in the acquisition and extinction of threat conditioning, a paradigm widely used to study emotional homeostasis, remain inconsistent, particularly in humans. This inconsistency is likely due to multiple factors, one of which is sample size. Here, we pooled functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) data from multiple studies in healthy humans to examine sex differences during threat conditioning, extinction learning, and extinction memory recall. We observed increased functional activation in males, relative to females, in multiple parietal and frontal (medial and lateral) cortical regions during acquisition of threat conditioning and extinction …

Trends In The Diversity Of Pediatric Faculty: 2000 To 2020, Emma A Omoruyi, Colin J Orr, Greg Russell, Kimberly Montez

Faculty, Staff and Student Publications

OBJECTIVE: Academic medicine diversity is important for addressing health disparities and training the next generation. A recent study highlighted the lack of diversity among pediatric trainees over time. However, trends in US pediatric faculty diversity have not been clearly illuminated. The aim of this study is to evaluate pediatric faculty diversity trends and compare racial/ethnic representation between pediatric faculty and the US population.

METHODS: Repeat cross-sectional study of the Association of American Medical Colleges Faculty Roster of pediatric faculty from 2000 to 2020. Trends in sex, race, ethnicity, and rank were compared with the Cochran-Armitage test. Data on faculty race/ethnicity …

A Quality Improvement Initiative To Decrease Time To Analgesia In Patients With Sickle Cell And Vaso-Occlusive Crisis: A Population With Disparities In Treatment, Tyler Arnold, R Lane Coffee, Leon Rosenberg, Seethal A Jacob, Sean Thompson, Heather Saavedra, Stephen John Cico, Brian Wagers

Faculty, Staff and Student Publications

INTRODUCTION: Vaso-occlusive crises (VOCs) are the leading cause of emergency department (ED) visits and hospitalizations in patients with sickle cell disease (SCD). Timely administration of analgesia, within 60 minutes of patient registration, is the standard of care for SCD patients with VOCs. Patients with VOCs have longer times to initial analgesia compared to similar painful conditions. The primary aim of the project is to have 75% of patients with VOCs receive initial analgesia within 60 minutes of being registered, the current recommended time frame from the National Heart, Lung, and Blood Institute (NHLBI).

METHODS: A multi-disciplinary team used quality improvement …

Cannabis Use And Sinonasal Symptoms In Us Adults, Francis Reyes Orozco, Matthew Lin, Kevin Hur

Faculty, Staff and Student Publications

IMPORTANCE: Cannabis is the most commonly used illicit substance in the US and worldwide. Understanding the association between cannabis use and sinonasal symptoms may help clinicians and patients better understand the symptomatology associated with cannabis use.

OBJECTIVE: To assess the association between frequency of cannabis use and presence of sinonasal symptoms in a nationally representative sample of US adults.

DESIGN, SETTING, AND PARTICIPANTS: This population-based, retrospective cross-sectional study included adults aged 20 to 69 years who had completed data on sinonasal symptoms and substance use for the 2013 to 2014 National Health and Nutrition Examination Survey. The data were analyzed …

Inducing Oscillations In Positive End-Expiratory Pressure Improves Assessment Of Cerebrovascular Pressure Reactivity In Patients With Traumatic Brain Injury, Jeanette Tas, Kirsten D J Bos, Joost Le Feber, Erta Beqiri, Marek Czosnyka, Roel Haeren, Iwan C C Van Der Horst, Sander M J Van Kuijk, Ulrich Strauch, Ken M Brady, Peter Smielewski, Marcel J H Aries

Faculty, Staff and Student Publications

The cerebral pressure reactivity index (PRx), through intracranial pressure (ICP) measurements, informs clinicians about the cerebral autoregulation (CA) status in adult-sedated patients with traumatic brain injury (TBI). Using PRx in clinical practice is currently limited by variability over shorter monitoring periods. We applied an innovative method to reduce the PRx variability by ventilator-induced slow (1/min) positive end-expiratory pressure (PEEP) oscillations. We hypothesized that, as seen in a previous animal model, the PRx variability would be reduced by inducing slow arterial blood pressure (ABP) and ICP oscillations without other clinically relevant physiological changes. Patients with TBI were ventilated with a static …

Predominantly Persistent Intraretinal Fluid In The Comparison Of Age-Related Macular Degeneration Treatments Trials, Jason Q Core, Maxwell Pistilli, Peiying Hua, Ebenezer Daniel, Juan E Grunwald, Cynthia A Toth, Glenn J Jaffe, Daniel F Martin, Maureen G Maguire, Gui-Shuang Ying, Comparison Of Age-Related Macular Degeneration Treatments Trials (Catt) Research Group

Faculty, Staff and Student Publications

PURPOSE: To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age-related macular degeneration.

DESIGN: Cohort within a randomized clinical trial.

PARTICIPANTS: Participants in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT) assigned to PRN treatment.

METHODS: The presence of intraretinal fluid (IRF) on OCT scans was assessed at baseline and monthly follow-up visits by Duke OCT Reading Center. Predominantly persistent intraretinal fluid through week 12, year 1, and year 2 was defined as the …

Hepatic Circadian And Differentiation Factors Control Liver Susceptibility For Fatty Liver Disease And Tumorigenesis, Baharan Fekry, Aleix Ribas-Latre, Rachel Van Drunen, Rafael Bravo Santos, Samay Shivshankar, Yulin Dai, Zhongming Zhao, Seung-Hee Yoo, Zheng Chen, Kai Sun, Frances M Sladek, Mamoun Younes, Kristin Eckel-Mahan

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths, and the most common primary liver malignancy to present in the clinic. With the exception of liver transplant, treatment options for advanced HCC are limited, but improved tumor stratification could open the door to new treatment options. Previously, we demonstrated that the circadian regulator Aryl Hydrocarbon-Like Receptor Like 1 (ARNTL, or Bmal1) and the liver-enriched nuclear factor 4 alpha (HNF4α) are robustly co-expressed in healthy liver but incompatible in the context of HCC. Faulty circadian expression of HNF4α- either by isoform switching, or loss of expression- results in an increased …

Dockopathies: A Systematic Review Of The Clinical Pathologies Associated With Human Dock Pathogenic Variants, Adrienne Samani, Katherine G English, Michael A Lopez, Camille L Birch, Donna M Brown, Gurpreet Kaur, Elizabeth A Worthey, Matthew S Alexander

Faculty, Staff and Student Publications

The Dedicator of Cytokinesis (DOCK) family (DOCK1-11) of genes are essential mediators of cellular migration, growth, and fusion in a variety of cell types and tissues. Recent advances in whole-genome sequencing of patients with undiagnosed genetic disorders have identified several rare pathogenic variants in DOCK genes. We conducted a systematic review and performed a patient database and literature search of reported DOCK pathogenic variants that have been identified in association with clinical pathologies such as global developmental delay, immune cell dysfunction, muscle hypotonia, and muscle ataxia among other categories. We then categorized these pathogenic DOCK variants and their associated clinical …

Mir-486 Is Essential For Muscle Function And Suppresses A Dystrophic Transcriptome, Adrienne Samani, Rylie M Hightower, Andrea L Reid, Katherine G English, Michael A Lopez, J Scott Doyle, Michael J Conklin, David A Schneider, Marcas M Bamman, Jeffrey J Widrick, David K Crossman, Min Xie, David Jee, Eric C Lai, Matthew S Alexander

Faculty, Staff and Student Publications

miR-486 is a muscle-enriched microRNA, or “myomiR,” that has reduced expression correlated with Duchenne muscular dystrophy (DMD). To determine the function of miR-486 in normal and dystrophin-deficient muscles and elucidate miR-486 target transcripts in skeletal muscle, we characterized mir-486 knockout mice (mir-486 KO). mir-486 KO mice developed disrupted myofiber architecture, decreased myofiber size, decreased locomotor activity, increased cardiac fibrosis, and metabolic defects were exacerbated in mir-486 KO:mdx5cv (DKO) mice. To identify direct in vivo miR-486 muscle target transcripts, we integrated RNA sequencing and chimeric miRNA eCLIP sequencing to identify key transcripts and pathways that contribute towards mir-486 …

Amphotericin B Resistance In Leishmania Mexicana: Alterations To Sterol Metabolism And Oxidative Stress Response, Edubiel A Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W Pountain, Stefan K Weidt, Anne M Donachie, Ryan Ritchie, Emily A Dickie, Richard J S Burchmore, Paul W Denny, Michael P Barrett

Faculty, Staff and Student Publications

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed that, in each resistant line, the predominant wild-type sterol, ergosta-5,7,24-trienol, was replaced by other sterol intermediates. Broadly, two different profiles emerged among the resistant lines. Whole genome sequencing then showed that these distinct profiles were due either to mutations in the sterol methyl transferase (C24SMT) gene locus or the sterol C5 desaturase (C5DS) gene. In three lines an additional deletion of …

Post–Lung Transplantation Outcomes And Ex Vivo Histopathological Findings In Severe Post-Covid-19 Pulmonary Disease—A Single-Center Experience, Hana Javaid, Masayuki Nigo, Bihong Zhao, Daniel Ocazionez Trujillo, Rodrigo Hasbun, Luis Ostrosky-Zeichner, Manish Patel, Soma Jyothula

Faculty, Staff and Student Publications

BACKGROUND: A significant proportion of patients with severe and persistent coronavirus disease 2019 (COVID-19) require continuous ventilatory support and occasional extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS). Lung transplantation is a treatment option for patients who develop severe ARDS.

METHODS: Our lung transplant database was retrospectively reviewed for patients who underwent lung transplantation for COVID-19 pulmonary disease at Memorial Hermann Hospital, Texas Medical Center, Houston, Texas, from January 2020 to March 2022. We evaluated outcomes of patients who were followed in our clinic at least 6 months post-transplant. Pretransplant patient characteristics, COVID-19-related treatment, histopathology results, and postdischarge …

Digital Money & Central Bank Digital Currency (Cbdc) - New Opportunity, New Challenge, G.A. Walker

The International Lawyer

No abstract provided.

Visualizing Politics In Indonesia: The Design And Distribution Of Election Posters, Colm A. Fox

Research Collection School of Social Sciences

Where studies have shown that visuals are the primary means of political communication, research continues to focus largely on text-based information. To add to our understanding of visual-political communications, this article analyses Indonesian election posters since the 1950s. Drawing on historical materials and on a content analysis of 4,000 election posters, it asks why election posters have been designed and distributed in particular ways. Findings indicate that in the past, posters used singular, though powerful, social symbols to mobilize demographic groups behind political parties. However, contemporary posters are more visually complex and more candidate-centered, making arguments as to what the …

Apoptotic Brown Adipocytes Enhance Energy Expenditure Via Extracellular Inosine, Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E Müller, Anke Tönjes, Christian Schlein, Azin Jafari, Holger K Eltzschig, Thorsten Gnad, Matthias Blüher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer

Faculty, Staff and Student Publications

Brown adipose tissue (BAT) dissipates energy

"Cerulean Skies" By Maria Schneider: A Formal And Semiotic Analysis, Jonathan Heim

Dissertations, Theses, and Capstone Projects

Expressivity, imagery, and narrativity have long been touted as hallmarks of big band composer Maria Schneider’s style. This perception is widely accepted by critics and casual commentators, but are these attributions merely metaphorical or do they speak to observable dimensions of Schneider’s compositional style? This dissertation aims to address the narrative and expressive dimensions of Schneider’s music by combining aspects of formal analysis with concepts from music semiotics. The centerpiece is an analysis of “Cerulean Skies” (2006), the longest work to date in Schneider’s oeuvre with a duration of approximately twenty-two minutes. “Cerulean Skies” is distinct in its expansiveness and …

Interpreting Jean Coulthard's Concerto For Piano And Orchestra (1963): A Pianist's Perspective, Jocelyn Lai

Dissertations, Theses, and Capstone Projects

Jean Coulthard (1908-2000) is recognized as one of Canada’s most prolific and important female classical composers in the twentieth century. She remained creatively active from her hometown of Vancouver, British Columbia, for eight decades, resulting in a catalog of over 350 works representing most classical music genres. Her music continues to be performed and recorded by renowned ensembles and soloists such as the Vancouver Symphony Orchestra, CBC Vancouver Orchestra, Calgary Philharmonic, Purcell String Quartet, pianists John Ogdon and Jane Coop, and contralto Maureen Forrester. Coulthard is known for her distinctive coloristic sonorities reminiscent of those in works by European composers …

"Secession's Moving Foundation": Fugitive Slave Rendition And The Politics Of American Slavery, Evan Turiano

Dissertations, Theses, and Capstone Projects

This dissertation examines the political conflict over fugitive slave rendition from the era of the American Revolution through the passage of the 1850 Fugitive Slave Law. It pays particular attention to the struggle over the legal rights due to African Americans accused of being fugitive slaves. Slaveholders claimed an absolute property right over accused fugitive slaves and argued that any recognition of legal remedies for accused runaways threatened that right. Free African Americans and their allies in the abolitionist movement asserted that Black people accused of having escaped slavery were due a legal process. This was a vital protection against …