Digital Commons Network^™

Coastal Stormwater Pond Pollutants And The Potential For Development Of Antimicrobial Resistance In Vibrio And Enterococcus Bacteria, Cassandra L. Horton

Theses and Dissertations

The Southeastern coastal plain is the most rapidly urbanizing region in the United States. Associated landscape changes which increase imperviousness lead to hydrological cycle alterations, increasing runoff of nonpoint source (NPS) pollution. Urban and agricultural NPS runoff is generally discharged into stormwater ponds, which sequester chemical contaminants, nutrients, and microbes to reduce loading into coastal ecosystems. Studies of these ponds have indicated elevated levels of trace metals, antimicrobial compounds, and bacterial contamination (SCSGC 2018).

Interactions of aquatic pathogens Vibrio vulnificus and Enterococcus faecium with trace metals (arsenic, copper, zinc) and clinically relevant antimicrobials (triclosan, ciprofloxacin, oxytetracycline) commonly found in coastal …

Novel Dietary Index For Gut Microbiota And Associations With Colorectal Cancer And Breast Cancer Risk, Bezawit Eyob Kase

Theses and Dissertations

Introduction: Diet serves as a driving force for shaping the gut microbiome. Understanding how diet may modify gut microbiota and subsequently may be associated with chronic disease is critical to public health prevention efforts. Aims: We aimed to develop a novel dietary index that captures the quality of diet with respect to attaining beneficial composition and function of gut microbiota. We then examined the relationship between the dietary index and two gut microbiota-related cancers, i.e., colorectal and breast cancers.

Methods: We conducted a systematic review of studies that examined the effect of foods on gut microbiota in adult populations. Dietary …

Implementing A Technology-Based Instructional Module In An Introduction To Engineering Course: The Impact On Student’S Vocabulary Retention And Attitudes Towards Learning, Robin T. Amick

Theses and Dissertations

The purpose of this study was to evaluate the academic impact of a technology-based instructional module for content vocabulary instruction in the Project Lead the Way (PLTW) Introduction to Engineering course. The goal of the study was to answer two key questions: 1) How does implementing a technology-based instructional module impact Engineering vocabulary academic gains for students taking the Introduction to Engineering course? and 2) What is the effect of implementing a technology-based instructional model on attitudes towards learning Engineering vocabulary for students taking the Introduction to Engineering course? This study was conducted with Introduction to Engineering students (N …

Peromyscus Maniculatus Bairdii And Peromyscus Maniculatus Sonoriensis Polymorphisms, Matthew Dixon Lucius

Theses and Dissertations

Sequencing technology has advanced greatly over the past couple of decades. This has led to many studies developing hypotheses based on genomic data. This requires many genomic studies to have up-to-date information on the species’ or subject’s genome being investigated. If a study does not have accurate or up-to-date background information, then they cannot fully develop their theories that are being established. In this study, I utilize outbred Peromyscus maniculatus, deer mice that are genetically diverse, to record the polymorphisms that are found throughout the Peromyscus maniculatus genome. I first explore the differences between the polymorphisms found in Peromyscus …

Elucidating The Interdependence Of Motor-Cognitive Development And Performance, Thomas Cade Abrams

Theses and Dissertations

As the development of complex coordination and control (i.e., motor development) involves the integration of neuromotor, psychological, social, and cognitive processes (i.e., executive functions), a better understanding of how these processes are embedded and manifest across stages of development throughout the lifespan is needed. The long-term processes associated with the acquisition and development of motor competence (MC), specifically, effortful practice and performance of various locomotor and object control skills, provide direct mechanisms for contributing to executive function (EF) development via different learning-related (e.g., synaptogenesis, hippocampal neurogenesis) as well as exercise-related (e.g., exercise-mediated neurogenesis, angiogenesis) mechanisms. However, traditional MC assessments use …

Decellularization Strategies Of Naturally Derived Biomaterials For Tissue Engineering Applications, Julia Elizabeth Hohn

Theses and Dissertations

In 2017, over 3.5 million peripheral vascular surgeries were performed worldwide with over 400,000 vascular repair or replacement surgeries being performed in the United States each year alone. As the number of vascular repair surgeries, including both coronary and peripheral bypass grafting procedures, continues to increase each year, these statistics indicate an urgent need for more effective and readily available replacement materials. Regenerative medicine and tissue engineering (TE) approaches, including the design, fabrication, and validation of suitable biomaterials in vitro that direct the repair and regeneration of damaged tissues, have been proposed to alleviate this problem. While advanced biomaterials have …

The Power Of Story In Developing A Cycle Of Efficacy For Teachers And Students, Melissa Renee Ewing

Theses and Dissertations

There is scarce nationwide evidence of the impact of instruction on student achievement in the area of writing (Coker et al., 2018; Persky et al., 2003; National Assessment of Educational Progress, 2002). Standardized writing assessment has shifted to text-dependent analysis, which requires students to read and analyze a passage and then compose an essay in response to a text dependent prompt. This type of writing requires students to understand how and why authors make decisions and then support a claim with analysis. This multiple-case, action research study followed three elementary teachers as they reflected on a journey resulting in transformation …

Xenobiotic Exposures On Women’S Reproductive Health, Maria Zubizarreta Mcclam

Theses and Dissertations

Environmental and chemical exposures are continually introduced into our bodies. The female reproductive cycle is complex and particularly sensitive to toxic substances. A recent rise in infertility and reproductive diseases and cancers make reproductive toxicity a public health concern. The overall purpose of this dissertation is to explore how environmental and chemical exposures impact women’s reproductive health and overall wellbeing. To do this, a variety of topics related to women’s reproductive health are explored, including how environmental exposures can impact reproduction, methods for studying reproductive dysfunctions, fertility preservation among cancer patients, and the overall wellbeing of female cancer patients.

The …

Supporting Black Children Within A Eurocratic Educational System: Making Culturally Relevant Pedagogy Foundational To The Role Of The Literacy Coach, Jennipher C.K. Frazier

Theses and Dissertations

This critical qualitative study documented what was learned about the process of making culturally relevant teaching foundational to the commitment of a literacy coach while working closely with a kindergarten and first grade teacher for one school year. Critical Race and Black Critical (BlackCrit) theories were the driving theoretical frameworks used to design the study, represent findings, and provide insight into the process of working to make culturally relevant pedagogy (CRP) foundational to the role of a literacy coach with a particular focus on supporting the Black child. The methods used to gain knowledge about CRP as foundational to the …

Coös County 4-H Project Record Book (Age 14-18), Christine Whiting

UNH Cooperative Extension

No abstract provided.

Coös County 4-H Project Record Book (Age 11-13), Christine Whiting

UNH Cooperative Extension

No abstract provided.

Coös County 4-H Project Record Book (Age 8-10), Christine Whiting

UNH Cooperative Extension

No abstract provided.

Sinclair Lewis Society Newsletter, Vol 31, No. 1, The Sinclair Lewis Society

Sinclair Lewis Society Newsletter

“Real America: A Speech about Sinclair Lewis by Lion Feuchtwanger,” with an introduction and translation by Sean Nye, University of Southern California

“‘Good Morning, America!’: A Retrospective of the 2022 Sinclair Lewis Virtual Conference,” by Shaun F. Richards

“Opening Remarks for the 2022 Sinclair Lewis Conference,” by Sally E. Parry, Illinois State University

“Three Midwestern Playwrights: How Floyd Dell, George Cram Cook, and Susan Glaspell Transformed American Theatre,” by Marcia Noe

“Robert L. McLaughlin’s Sinclair Lewis Scholarship”

“Play of Main Street Produced at University of Minnesota Duluth,” by George Killough, College of St. Scholastica

“Revisiting Sinclair Lewis’s Kingsblood Royal,” by …

Signs & Symbols, Vol. 22, Fall 2022, Illinois State University, Department Of Sociology And Anthropology

Signs & Symbols

Newsletter of the Illinois State University Department of Sociology and Anthropology

Role Of Sam68 In Sunitinib Induced Renal Cell Carcinoma Apoptosis, Zeshen Wu, Yulu Peng, Longbin Xiong, Jun Wang, Zhen Li, Kang Ning, Minhua Deng, Ning Wang, Wensu Wei, Zhiyong Li, Pei Dong, Chunping Yu, Fangjian Zhou, Zhiling Zhang

Faculty, Staff and Student Publications

Sunitinib is one of the first-line targeted drugs for metastatic renal cell carcinoma (RCC) with dual effects of antiangiogensis and proapoptosis. Sam68 (Src-associated in mitosis, 68 KDa), is found being involved in cell apoptosis. This article reveals that Sam68 impacts the sensitivity to sunitinib by mediating the apoptosis of RCC cells. Immunohistochemical staining indicated that the Sam68 expression levels in sunitinib sensitive tumor tissues were markedly higher than those in sunitinib resistant tumor tissues. Sunitinib induced RCC cell apoptosis in a concentration-dependent manner and inhibited the expression of total and phosphorylated Sam68 (p-Sam68). Downregulation of Sam68 expression inhibited RCC cell …

Heterozygous Variants In Myh10 Associated With Neurodevelopmental Disorders And Congenital Anomalies With Evidence For Primary Cilia-Dependent Defects In Hedgehog Signaling, Alexander M Holtz, Rachel Vancoillie, Elizabeth A Vansickle, Deanna Alexis Carere, Kara Withrow, Erin Torti, Jane Juusola, Francisca Millan, Richard Person, Maria J Guillen Sacoto, Yue Si, Ingrid M Wentzensen, Jada Pugh, Georgia Vasileiou, Melissa Rieger, André Reis, Emanuela Argilli, Elliott H Sherr, Kimberly A Aldinger, William B Dobyns, Theresa Brunet, Julia Hoefele, Matias Wagner, Benjamin Haber, Urania Kotzaeridou, Boris Keren, Delphine Heron, Cyril Mignot, Solveig Heide, Thomas Courtin, Julien Buratti, Serini Murugasen, Kirsten A Donald, Emily O'Heir, Shade Moody, Katherine H Kim, Barbara K Burton, Grace Yoon, Miguel Del Campo, Diane Masser-Frye, Mariya Kozenko, Christina Parkinson, Susan L Sell, Patricia L Gordon, Jeremy W Prokop, Amel Karaa, Caleb Bupp, Benjamin A Raby

Faculty, Staff and Student Publications

PURPOSE: Nonmuscle myosin II complexes are master regulators of actin dynamics that play essential roles during embryogenesis with vertebrates possessing 3 nonmuscle myosin II heavy chain genes, MYH9, MYH10, and MYH14. As opposed to MYH9 and MYH14, no recognizable disorder has been associated with MYH10. We sought to define the clinical characteristics and molecular mechanism of a novel autosomal dominant disorder related to MYH10.

METHODS: An international collaboration identified the patient cohort. CAS9-mediated knockout cell models were used to explore the mechanism of disease pathogenesis.

RESULTS: We identified a cohort of 16 individuals with heterozygous MYH10 variants presenting with a …

Mesenchymal Stromal Cells For The Treatment Of Alzheimer’S Disease: Strategies And Limitations, Shobha Regmi, Daniel Dan Liu, Michelle Shen, Bhavesh D Kevadiya, Abantika Ganguly, Rosita Primavera, Shashank Chetty, Reza Yarani, Avnesh S Thakor

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is a major cause of age-related dementia and is characterized by progressive brain damage that gradually destroys memory and the ability to learn, which ultimately leads to the decline of a patient's ability to perform daily activities. Although some of the pharmacological treatments of AD are available for symptomatic relief, they are not able to limit the progression of AD and have several side effects. Mesenchymal stem/stromal cells (MSCs) could be a potential therapeutic option for treating AD due to their immunomodulatory, anti-inflammatory, regenerative, antioxidant, anti-apoptotic, and neuroprotective effects. MSCs not only secret neuroprotective and anti-inflammatory factors …

Age Cutoff For Early‐Onset Parkinson's Disease:Recommendations From The International Parkinson And Movement Disorder Society Task Force On Early Onset Parkinson's Disease, Raja Mehanna, Katarzyna Smilowska, Jori Fleisher, Bart Post, Taku Hatano, Maria Elisa Pimentel Piemonte, Kishore Raj Kumar, Victor Mcconvey, Baorong Zhang, Eng-King Tan, Rodolfo Savica, International Parkinson And Movement Disorder Society Task Force On Early Onset Parkinson's Disease

Faculty, Staff and Student Publications

BACKGROUND: Early-onset Parkinson's disease (EOPD)/young-onset Parkinson's disease (YOPD) is defined as Parkinson's disease (PD) with an age at onset (AAO) after age 21 years but before the usual AAO for PD. Consensus is lacking, and the reported maximal age for EOPD/YOPD has varied from 40 to 60 years, leading to a lack of uniformity in published studies and difficulty in harmonization of data. EOPD and YOPD have both been used in the literature, somewhat interchangeably.

OBJECTIVE: To define the nomenclature and AAO cutoff for EOPD/YOPD.

METHODS: An extensive review of the literature and task force meetings were conducted. Conclusions were …

A Hydrogen-Sulfide Derivative Of Mesalamine Reduces The Severity Of Intestinal And Lung Injury In Necrotizing Enterocolitis Through Endothelial Nitric Oxide Synthase, Brian D Hosfield, Chelsea E Hunter, Hongge Li, Natalie A Drucker, Anthony R Pecoraro, Krishna Manohar, W Christopher Shelley, Troy A Markel

Faculty, Staff and Student Publications

Necrotizing enterocolitis (NEC) remains a devastating disease that affects preterm infants. Hydrogen sulfide (H2S) donors have been shown to reduce the severity of NEC, but the optimal compound has yet to be identified. We hypothesized that oral H2S-Mesalamine (ATB-429) would improve outcomes in experimental NEC, and its benefits would be dependent on endothelial nitric oxide synthase (eNOS) pathways. NEC was induced in 5-day-old wild-type (WT) and eNOS knockout (eNOSKO) pups by formula feeding and stress. Four groups were studied in both WT and eNOSKO mice: 1) breastfed controls, 2) NEC, 3) NEC + 50 mg/kg mesalamine, and …

Ags And Nia Bench-To Bedside Conference Summary: Cancer And Cardiovascular Disease, Supriya Mohile, Caroline S Blaum, Peter M Abadir, William Dale, Daniel E Forman, Chunkit Fung, Holly M Holmes, Javid Moslehi, Karen M Mustian, Michael W Rich, Heather E Whitson

Faculty, Staff and Student Publications

This report summarizes the presentations, discussions, and recommendations of the most recent American Geriatrics Society and National Institute on Aging research conference, "Cancer and Cardiovascular Disease," on October 18-19, 2021. The purpose of this virtual meeting was to address the interface between cancer and heart disease, which are the two leading causes of death among older Americans. Age-related physiologic changes are implicated in the pathogenesis of both conditions. Emerging data suggest that cancer-related cardiovascular disease (CVD) involves disrupted cell signaling and cellular senescence. The risk factors for CVD are also risk factors for cancer and an increased likelihood of cancer …

Volatiles In Berries: Biosynthesis, Composition, Bioavailability, And Health Benefits, Inah Gu, Luke Howard, Sun-Ok Lee

Food Science Faculty Publications and Presentations

Abstract

In Vivo Evaluation Of A New Hybrid Graft Using Retrograde Visceral Perfusion For Thoracoabdominal Aortic Repair In An Animal Model, Sabine Wipper, Harleen K Sandhu, Tilo Kölbel, Anthony L Estrera, Constantin Trepte, Christoph Behem, Charles C Miller, E Sebastian Debus

Faculty, Staff and Student Publications

OBJECTIVES: The SPIDER technique for hybrid thoracoabdominal aortic aneurysm repair can avoid thoracotomy and extracorporeal circulation. To improve technical feasibility and safety, the new Thoracoflo graft, consisting of a proximal stent graft connected to a 7-branched abdominal prosthesis, was evaluated in a pig model for technical feasibility testing, before implantation in humans.

METHODS: Retroperitoneal exposure of the infradiaphragmatic aorta, including visceral and renal arteries, was performed in 7 pigs (75-85 kg). One iliac branch was temporarily attached to the distal aorta to maintain retrograde visceral and antegrade iliac perfusion after deployment of the thoracic stent graft segment (SPIDER technique). The …

Experiential Learning In Patient Safety: A Multi-Center Study Examining Emergency Medicine Residents' Situational Awareness Of Hazards Via Simulation, Kamna S Balhara, Nathan Olson, Jessica L Wilson, Rosemarie G Ramos, Harlan J Goode, Andrew E Muck, Adriana S Olson

Faculty, Staff and Student Publications

Introduction The 2016 Clinical Learning Environment Review established that experiential patient safety curricula for residents are uncommon. Moreover, these curricula do not incorporate non-technical skills linked to safety, such as situational awareness (SA). We developed an in-situ patient safety simulation exercise incorporating core SA concepts and subsequently assessed exercise feasibility and acceptability, and measured residents' safety SA. Methods A simulation scenario and mock chart were designed, incorporating 16 patient safety hazards. Residents at two institutions reviewed the chart and had 10 minutes in an emergency department room with the simulated scenario to document identified hazards, followed by a facilitated debriefing. …

Sex Differences In Clinical Outcomes And Biological Profiles In Systemic Sclerosis-Associated Interstitial Lung Disease: A Post-Hoc Analysis Of Two Randomised Controlled Trials, Elizabeth R Volkmann, Donald P Tashkin, Richard Silver, Carol Feghali Bostwick, Shervin Assassi, Deanna Baker Frost, Mei Leng, Holly Wilhalme, Grace Hyun Kim, Jonathan Goldin, Michael D Roth

Faculty, Staff and Student Publications

BACKGROUND: Observational studies have shown that men with systemic sclerosis have an increased risk of interstitial lung disease (ILD) and mortality compared with women. However, previous studies have not controlled for treatment effect or evaluated the biological mechanism or mechanisms underlying this sex difference. We aimed to compare ILD progression and long-term morbidity and mortality outcomes in male and female participants of two randomised controlled trials for systemic sclerosis-associated ILD.

METHODS: For this post-hoc analysis, data from all participants in the Scleroderma Lung Study (SLS) I and SLS II were analysed. The primary objective was to explore the effect of …

Consulting The Faithful: John Henry Newman’S Relevance For A Fully Catholic Synodality, Shaun Blanchard Ph.D.

Spiritan Horizons

No abstract provided.

Usd Magazine Fall 2022, University Of San Diego

University of San Diego Magazine (1992- )

Torero News; Torero Athletics; Relentless Incrementalism; Hard Work Works; Forward Motion; Class Notes

Traffic Accidents Analysis & Prediction In Uae, Majid Alhosani

Theses

UAE has state-of-the-art roads and traffic infrastructure, and yet there has been a rapid increase in the number of traffic accidents. As per National Agenda 2021, the UAE traffic departments are working to minimize the rate of road traffic death per 100 thousand people. The Traffic and Patrols Directorate in Abu Dhabi launched a road safety management plan. This aims at decreasing the fatalities from traffic accidents to 3 per 100,000 inhabitants by 2021. According to police, distracted driving, sudden swerving, entering a road without ensuring that it is clear, tailgating and speeding without considering the road conditions has caused …

Why We Should Remember The Soviet Information Age?, Ksenia Tatarchenko

Research Collection College of Integrative Studies

How to navigate the rapidly changing digital geopolitics of the world today? How do we make sense of digital transformation and its many social, political, cultural, and environmental implications at different locations around the world?

Structured Reflection Increases Intentions To Reduce Other People’S Health Risks During Covid-19, Jairo Ramos, Marrissa D. Grant, Stephan Dickert, Kimin Eom, Alex Flores, Gabriela M. Jiga-Boy, Tehila Kogut, Marcus Mayorga, Eric J. Pedersen, Beatriz Pereira, Enrico Rubaltelli, K Sherman David, Paul Slovic, Västjäll. Daniel, Leaf Van Boven

Research Collection School of Social Sciences

People believe they should consider how their behavior might negatively impact other people, Yet their behavior often increases others’ health risks. This creates challenges for managing public health crises like the COVID-19 pandemic. We examined a procedure wherein people reflect on their personal criteria regarding how their behavior impacts others’ health risks. We expected structured reflection to increase people's intentions and decisions to reduce others’ health risks. Structured reflection increases attention to others’ health risks and the correspondence between people's personal criteria and behavioral intentions. In four experiments during COVID-19, people (N = 12,995) reported their personal criteria about how …

From Shared Micro-Mobility To Shared Responsibility: Using Crowdsourcing To Understand Dockless Vehicle Violations In Austin, Texas, Shunhua Bai, Junfeng Jiao

Research Collection College of Integrative Studies

In recent years, many progressive U.S. cities have witnessed the rapid popularization of dockless small vehicles as a car-free travel alternative to meet the short distance travel demand. The research gap exists in revealing the social outcome of the massive influx of shared small vehicles on public space. To that end, this study analyzed 4,100 parking violation reports in Austin, Texas, crowdsourced from the Austin 311 non-emergency service request system. The results showed that sidewalk and other public space intrusions were the two most frequently reported violations. Additionally, it found that improperly parked vehicles in parks required the longest time …