Digital Commons Network^™

De Novo Variants In Frmd5 Are Associated With Developmental Delay, Intellectual Disability, Ataxia, And Abnormalities Of Eye Movement, Shenzhao Lu, Mengqi Ma, Xiao Mao, Carlos A Bacino, Joseph Jankovic, V Reid Sutton, James A Bartley, Xueying Wang, Jill A Rosenfeld, Ana Beleza-Meireles, Jaynee Chauhan, Xueyang Pan, Megan Li, Pengfei Liu, Katrina Prescott, Sam Amin, George Davies, Michael F Wangler, Yuwei Dai, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

Proteins containing the FERM (four-point-one, ezrin, radixin, and moesin) domain link the plasma membrane with cytoskeletal structures at specific cellular locations and have been implicated in the localization of cell-membrane-associated proteins and/or phosphoinositides. FERM domain-containing protein 5 (FRMD5) localizes at cell adherens junctions and stabilizes cell-cell contacts. To date, variants in FRMD5 have not been associated with a Mendelian disease in OMIM. Here, we describe eight probands with rare heterozygous missense variants in FRMD5 who present with developmental delay, intellectual disability, ataxia, seizures, and abnormalities of eye movement. The variants are de novo in all for whom parental testing was …

Tryptophan Oxidation In Young Children With Environmental Enteric Dysfunction Classified By The Lactulose Rhamnose Ratio, Nirupama Shivakumar, Jean W Hsu, Sindhu Kashyap, Tinku Thomas, Anura V Kurpad, Farook Jahoor

Faculty, Staff and Students Publications

BACKGROUND: In young children, associations between linear growth faltering, environmental enteric dysfunction (EED), and the plasma kynurenine (Kyn)/tryptophan (Trp) ratio (KTR) have led to the proposal that higher Trp catabolism in response to intestinal/systemic inflammation limits Trp availability for protein synthesis, resulting in impaired growth.

OBJECTIVES: We sought to estimate the Trp oxidation rate and the Trp conversion rate to Kyn in young children with and without EED.

METHODS: Children aged 18-24 mo, from urban slums, were assigned to EED (n = 19) or no-EED (n = 26) groups on the basis of a urinary lactulose/rhamnose ratio (LRR) cutoff based …

Effect Of Edutainment Videos On Literacy Skills Acquisition Among Preschool Children. Implications For Updating Children's Audio-Visual Library, Akobi Thomas Ogbeche Dr, Chinedu Ifedi Okeke Prof.

Library Philosophy and Practice (e-journal)

The need for the use of edutainment videos in the teaching and learning of preschool children cannot be overstated. This study therefore examined the effect of edutainment videos on literacy skills acquisition among preschool children. Implication for updating children’s audio-visual library. Two research questions and three hypotheses guided the study. The study adopted the non-equivalent pretest posttest quasi-experimental research design. The study population comprised all the nursery three preschool children in Nsukka LGA for the 2021/2022 academic year. A sample of 95 preschool children drawn through judgmental sampling technique were studied. The Literacy Skills Acquisition Test (LSAT) was the instrument …

Usa V. Judy Haisten

2022 Decisions

USDC for the Eastern District of Pennsylvania

Rural-Urban Migration And The Re-Organization Of Agriculture, Raahil Madhok, Frederik Noack, Ahmed Mushfiq Mobarak, Olivier Deschenes

Discussion Papers

This paper studies the response of agricultural production to rural labor loss during the process of urbanization. Using household microdata from India and exogenous variation in migration induced by urban income shocks interacted with distance to cities, we document sharp declines in crop production among migrant-sending households residing near cities. Households with migration opportunities do not substitute agricultural labour with capital, nor do they adopt new agricultural machinery. Instead, they divest from agriculture altogether and cultivate less land. We use a two-sector general equilibrium model with crop and land markets to trace the ensuing spatial reorganization of agriculture. Other non-migrant …

Wellness Review 2022, Part 1, Martin Huecker, Brian A. Ferguson, Jacob Shreffler

Journal of Wellness

Introduction: This article represents the first of a two-part assessment of 2022 literature addressing wellness in healthcare professionals published from January 1, 2022 to June 30, 2022.

Methods: Three editors conducted a similar keyword search in Pubmed, also adding manually curated articles. Focusing chiefly on clinical trials and other prospective research, we settled on a final 25 significant papers focusing on wellness in medical professionals to include in this review.

Literature Review: Recent literature into HCW wellness continues to describe burnout factors and COVID-19 impact, but includes more resilience-targeting interventions and systematic reviews of trials seeking bolstering of well-being. Subsections …

The Effects Of Exercise Training On Glucose Homeostasis And Muscle Metabolism In Type 1 Diabetic Female Mice, Caitlin O'Neill, Erica J. Locke, Darren A. Sipf, Jack Thompson, Erin Drebushenko, Nate Berger, Brooke Segich, Stephen C. Kolwicz Jr.

Health Sciences Faculty Publications

Although exercise training is an important recommendation for the management of type 1 diabetes (T1D), most of the available research studies predominantly focus on male subjects. Given the importance of sex as a biological variable, additional studies are required to improve the knowledge gap regarding sex differences in T1D research. Therefore, the purpose of this study was to examine the role of exercise training in mediating changes in glucose homeostasis and skeletal muscle metabolism in T1D female mice. Female mice were injected with streptozotocin (STZ) to induce T1D. Two weeks after STZ injection, control (CON) and STZ mice were exercise …

The Emergence Of Convergence, Shana M. Sundstrom, David G. Angeler, Jessica G. Ernakovich, Jorge H. Garcıá, Joseph A. Hamm, Orville Huntington, Craig R. Allen

School of Natural Resources: Faculty Publications

Science is increasingly a collaborative pursuit. Although the modern scientific enterprise owes much to individuals working at the core of their field, humanity is increasingly confronted by highly complex problems that require the integration of a variety of disciplinary and methodological expertise. In 2016, the U.S. National Science Foundation launched an initiative prioritizing support for convergence research as a means of “solving vexing research problems, in particular, complex problems focusing on societal needs.” We discuss our understanding of the objectives of convergence research and describe in detail the conditions and processes likely to generate successful convergence research. We use our …

Comparative Analysis Of Untargetedmetabolomics In Tolerant And Sensitive Genotypes Of Common Bean (Phaseolus Vulgaris L.) Seeds Exposed To Terminal Drought Stress, Mayavan Subramani, Carlos Urrea, Venu Kalavacharla

Panhandle Research and Extension Center

Many environmental stresses can affect the accumulation of metabolites in plants, including drought. In the present study, we found a great deal of variability in the seed metabolic profiles of the tolerant (Matterhorn, SB-DT2 and SB-DT3) common bean genotypes in comparison to the sensitive genotypes (Sawtooth, Merlot and Stampede) using ultrahigh performance liquid chromatography􀀀tandem mass spectrometry (UPLC-MS). The genotypes were grown in the field and subjected to drought stress after flowering (terminal drought stress). We aimed to investigate the accumulation of genotype-specific metabolites and related pathways under terminal drought stress by comparing tolerant and sensitive genotypes within a race. A …

Disney Animated Movies, Their Princesses, And Everyone Else, Alia R. Tyner

Publications and Research

In April 2021, The Walt Disney Company (Disney) announced the Ultimate Princess Celebration, ‘a year-long event spotlighting the courage and kindness these Disney heroines inspire in fans all around the world’ (Deitchman, 2021). Princesses have remained an important element of Disney’s identity and the movies they create. Broadening research beyond these characters and examining a larger sample demonstrated distinctions in the characteristics present in Official Disney Princess (ODP) movies, Actual Princess (AP) movies, and the 45 in the full catalog (All-Movies) that are or share characteristics with Disney Princess Movies. This article compares the race, class, and gender of the …

Biological Treatment Of Cannery Wastes, Yung-Tse Hung, Seyedkiarash Sharifiilierdy, Howard H. Paul, Christopher R. Huhnke, Rehab O, Abdel Rahman

Civil and Environmental Engineering Faculty Publications

This chapter reviews various methods of cannery wastewater biological treatment, namely up-flow anaerobic sludge blanket (UASB), sequencing batch reactor (SBR), three-stage aerobic rotating biological contactor (RBC), three sequentially arranged reactors (anaerobic-anoxic-aerobic reactors), lagooning, and anaerobic digestion. The general principles for dealing with the uncertainty of general wastewater treatment plants are applied to control the uncertainty in cannery wastewater treatment. An overview of on the application of Monte Carlo, support vector machine (SVM), artificial neural network (ANN), and genetic algorithm to manage the uncertainty in the biological treatment of wastewater is provided.

What? Is Epstein–Barr Virus Infection Linked To Multiple Sclerosis?, Asha Mahajan, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Moral Values, Social Ideologies, And Threat-Based Cognition: Implications For Intergroup Relations., Brandon D. Stewart Phd, David S. M. Morris

Faculty Publications

Moral foundations theory (MFT) has provided an account of the moral values that underscore different cultural and political ideologies, and these moral values of harm, fairness, loyalty, authority, and purity can help to explain differences in political and cultural ideologies; however, the extent to which moral foundations relate to strong social ideologies, intergroup processes and threat perceptions is still underdeveloped. To explore this relationship, we conducted two studies. In Study 1 (N = 157), we considered how the moral foundations predicted strong social ideologies such as authoritarianism (RWA) and social dominance orientation (SDO) as well as attitudes toward immigrants. …

The College Voice, Vol. 57, No. 2 [October 5, 2022], Connecticut College

2022-2023

No abstract provided.

Spectrum, Volume 49, Issue 4, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: High Praise for Journalism -- Frustrations Mount as Hurricane Ian’s Effects Linger -- Maura Cook Setting the Bar High for SHU Staff -- Getting Strange at Sacred Heart -- How do YOU deal with Mental Health? -- Welcome Back Alumni! -- Getting Groovy on the Quad!

Rub-A-Dub-Dub, One Kid In The Tub, Jerry Zezima

Erma Bombeck Writers' Workshop Blog

Grandchildren can make you deliriously happy, as ours always do, but they can also drive you to drink. And not from a sippy cup.

The Lumberjack, October 05, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

High School Principal's Perception And Experience With Student Voice And Youth-Adult Partnerships, James D. Flynn

Theses and Dissertations

High school principals can foster student voice (SV) and youth-adult partnerships (YAP) while leading their students towards being engaged and informed citizens in our democracy. It is critical to understand the advantages and opportunities high school principals have in listening to and partnering with their students. It is also critical to understand the challenges facing high school principals in their journey towards SV and YAP. A qualitative multicase study of 10 high school principals from across the nation was used to understand the perception and experiences of high school principals in the area of SV and YAP. In addition, this …

October 5, 2022, The Dakota Student

The Dakota Student

No abstract provided.

Rural-Urban Migration And The Re-Organization Of Agriculture, Raahil Madhok, Frederik Noack, Ahmed Musfiq Mobarak, Olivier Deschenes

Cowles Foundation Discussion Papers

This paper studies the response of agricultural production to rural labor loss during the process of urbanization. Using household microdata from India and exogenous variation in migration induced by urban income shocks interacted with distance to cities, we document sharp declines in crop production among migrant-sending households residing near cities. Households with migration opportunities do not substitute agricultural labour with capital, nor do they adopt new agricultural machinery. Instead, they divest from agriculture altogether and cultivate less land. We use a two-sector general equilibrium model with crop and land markets to trace the ensuing spatial reorganization of agriculture. Other non-migrant …

Identification Of Minimum Essential Therapeutic Mixtures From Cannabis Plant Extracts By Screening In Cell And Animal Models Of Parkinson’S Disease, Michael G Morash, Jessica Nixon, Lori M N Shimoda, Helen Turner, Alexander J Stokes, Andrea L Small-Howard, Lee D Ellis

Faculty, Staff and Student Publications

Medicinal cannabis has shown promise for the symptomatic treatment of Parkinson's disease (PD), but patient exposure to whole plant mixtures may be undesirable due to concerns around safety, consistency, regulatory issues, and psychoactivity. Identification of a subset of components responsible for the potential therapeutic effects within cannabis represents a direct path forward for the generation of anti-PD drugs. Using an

The Boring Schwann Cells: Tumor Me-Tast-Asis Along Nerves, Moran Amit, Anirban Maitra

Faculty, Staff and Student Publications

Perineural spread is an ominous feature of cancer. Here, Deborde and colleagues describe for the first time the biophysical coupling driving this route of tumor spread and the role of Schwann cell activation in the mobilization of cancer cells within and along the tumor-associated nerves. See related article by Deborde et al., p. 2454 (8).

Peripheral Blood Monocytes As A Therapeutic Target For Marrow Stromal Cells In Stroke Patients, Nikunj Satani, Kaushik Parsha, Courtney Davis, Adrian Gee, Scott D Olson, Jaroslaw Aronowski, Sean I Savitz

Faculty, Staff and Student Publications

BACKGROUND: Systemic administration of marrow stromal cells

METHODS: Peripheral blood from stroke patients was collected at 5-7 days (

RESULTS: Our results show that there is a higher release of IFN-γ and IL-10 from monocytes isolated from peripheral blood at day 5-7 after stroke compared with monocytes from healthy controls. In trans-well co-cultures of MSCs and monocytes isolated from stroke patients, we found statistically significant increased levels of IL-4 and MCP-1, and decreased levels of IL-6, IL-1β, and TNF-α. Addition of MSCs to monocytes increased the secretions of Fractalkine, IL-6, and MCP-1, while the secretions of TNF-α decreased, as compared …

Phytochemical Screening, And Antibacterial And Antioxidant Activities Of Mangifera Indica L. Leaves, Arvish Maharaj, Yougasphree Naidoo, Yaser Hassan Dewir, Hail Rihan

School of Biological and Marine Sciences

The bio-constituents of medicinal plants are greatly influenced by the environmental conditions and growing seasons. This study aimed to uncover the presence of different metabolites and to investigate the biological properties of the leaves of Mangifera indica during summer and winter seasons. The extract of M. indica leaves for summer and winter using different solvent extracts (hexane, chloroform, and methanol) showed the presence of phenols, flavonoids, tannins, terpenoids, alkaloids, phytosterol, saponins, steroids, and carbohydrates. Antibacterial activity of the methanolic leaf extracts for summer and winter were evaluated against the bacterial species Staphylococcus aureus (ATCC 43300) and Escherichia coli (ATCC 25922). …

Winonan, Winona State University

The Winonan - 2020s

This issue of the Winonan was published on October 5, 2022.

Editorial: Plastics In The Environment: Understanding Impacts And Identifying Solutions, Volume Ii, Montserrat Filella, Andrew Turner, John Scott

School of Geography, Earth and Environmental Sciences

Our first collection of Frontiers articles highlighted the broad diversity of environmental problems caused by the mismanagement of plastics in different settings, and the many challenges that scientists, managers, regulators and stakeholders face in addressing these problems (Filella et al., 2021). This, second series essentially deals with plastics in soils and the degradation of plastic (and in particular, expanded polystyrene). Improving the circularity and management of plastics in soils requires an understanding of their presence, impacts and degradation pathways.

Unravelling The Reservoirs For Colonisation Of Infants With Campylobacter Spp. In Rural Ethiopia: Protocol For A Longitudinal Study During A Global Pandemic And Political Tensions, Arie H Havelaar, Mark J Manary, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Undernutrition is an underlying cause of mortality in children under five (CU5) years of age. Animal-source foods have been shown to decrease malnutrition in CU5. Livestock are important reservoirs for

METHODS AND ANALYSIS: This longitudinal study involves 115 infants who are followed from birth to 12 months of age and are selected randomly from 10 kebeles of Haramaya woreda, East Hararghe zone, Oromia region, Ethiopia. Questionnaire-based information is obtained on demographics, livelihoods, wealth, health, nutrition and women empowerment; animal ownership/management and diseases; and water, sanitation and hygiene. Faecal samples are collected from infants, mothers, siblings and livestock, drinking water …

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

New Web Site Debuts

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The Neal A. Maxwell Institute for Religious Scholarship unveiled its new Web site on 1 Nov-ember 2006. The new site, found at maxwellinsti-tute.byu.edu, features all the material that resided on the FARMS Web site as well as additional con-tent and links from all departments that make up the Institute.

Deer As “Goat” And Pre-Columbian Domesticate, Matthew Roper

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Sometime after the death of his father Jacob, Enos wrote that the Nephites raised “flocks of herds, and flocks of all manner of cattle of every kind, and goats, and wild goats” (Enos 1:21). While contemporary archaeology thus far has not yielded evidence of pre-Columbian goats, anthropologist John L. Sorenson has suggested that Book of Mormon peoples, like the Spanish writers of a later time, may have considered some species of pre-Columbian deer to be a kind of goat.