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Medical School Watercooler Newsletter - October 13, 2022, Lindsey Lyle

Watercooler Newsletter

This is the October 13, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Student-Run Free Clinic to offer free flu shots
• Arrieta named interim director of USA Center for Healthy Communities
• Surgery faculty discuss laser therapy for burns at national burn conference
• Leavesley to present on hyperspectral imaging for tissue diagnosis
• Interventional neurologist joins neurology faculty
• Meet a Med Student: Madison Hogans

Mendelian Gene Identification Through Mouse Embryo Viability Screening., Pilar Cacheiro, Carl Henrik Westerberg, Jesse Mager, Mary E Dickinson, Lauryl M J Nutter, Violeta Muñoz-Fuentes, Chih-Wei Hsu, Ignatia B Van Den Veyver, Ann M Flenniken, Colin Mckerlie, Stephen A Murray, Lydia Teboul, Jason D Heaney, K C Kent Lloyd, Louise Lanoue, Robert E Braun, Jacqueline K White, Amie K Creighton, Valerie Laurin, Ruolin Guo, Dawei Qu, Sara Wells, James Cleak, Rosie Bunton-Stasyshyn, Michelle Stewart, Jackie Harrisson, Jeremy Mason, Hamed Haseli Mashhadi, Helen Parkinson, Ann-Marie Mallon, International Mouse Phenotyping Consortium, Genomics England Research Consortium, Damian Smedley

Faculty Research 2022

BACKGROUND: The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is particularly challenging and strategies combining gene functional evidence with approaches that evaluate the phenotypic similarities between patients and model organisms have proven successful. A full spectrum of intolerance to loss-of-function variation has been previously described, providing evidence that gene essentiality should not be considered as a simple and fixed binary property.

METHODS: Here we further dissected this spectrum by assessing the embryonic stage at which homozygous …

Physicians’ Considerations And Practice Recommendations Regarding The Use Of Sodium-Glucose Cotransporter-2 Inhibitors, Serge A. Jabbour, Nasrien E. Ibrahim, Christos P. Argyropoulos

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) (canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin), although initially developed as glucose-lowering drugs, provide significant beneficial effects on cardiorenal outcomes, including heart failure, regardless of type 2 diabetes status. Integration of SGLT-2is into clinical practice requires practical guidance for physicians about their use. To overcome physicians’ clinical inertia for SGLT-2i use, including addressing safety, potentially a barrier to their use, a roundtable discussion with physicians from three specialties (cardiology, endocrinology, and nephrology) was conducted. This review summarizes the physicians’ clinical experience and recommendations about SGLT-2i use across different patient populations, taking into consideration the beneficial effects of SGLT-2is …

The Effects Of Administering Different Metaphylactic Antimicrobials On Growth Performance And Health Outcomes Of High-Risk, Newly Received Feedlot Steers, Carley M. Coppin, Taylor M. Smock, Cory L. Helmuth, Jeff L. Manahan, Nathan S. Long, Ashley A. Hoffman, Jeffery A. Carroll, Paul R. Broadway, Nicole C. Burdick Sanchez, James E. Wells, Samodha C. Fernando, Kristin E. Hales

Department of Animal Science: Faculty Publications

Bovine respiratory disease (BRD) is the primary animal health concern facing feedlot producers. Many antimicrobial mitigation strategies are available, but few studies have compared feedlot performance during both the receiving and finishing periods following application of different antimicrobials used as metaphylaxis at arrival. The objective of this study was to compare antimicrobial metaphylaxis methods on clinical health and growth performance across both the receiving and finishing periods. A total of 238 multiple-sourced steers in two source blocks were used in a generalized complete block design. The four treatments included: 1) a negative control, 5 mL of sterile saline injected subcutaneously …

The Montclarion, October 13, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

The Weekly Challenger, October 13, 2022, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The October 13, 2022, issue of The Weekly Challenger.

The Roles Of Polysaccharides In Tilapia Farming: A Review, Zulhisyam Abdul Kari, Wendy Wee, Noor Khalidah Abdul Hamid, Mahmoud A.O. Dawood

Faculty Journal Articles

Impairment of fish growth and immune system due to stress and disease are major constraints in aquaculture industry. Traditionally, antibiotic was used as prophylactic agent in the health management of aquaculture species. However, antibiotic only provide a temporary solution to the problem of disease outbreak. Over-reliance on antibiotic also has led to the increasing cases of antibiotic resistance among pathogenic bacteria from aquaculture sites and contamination of antibiotic residues into human food chain. Probiotic, prebiotic and symbiotic are therefore suggested as alternatives to prophylactic antibiotic to be used in the aquaculture industry. A potential prophylactic agent is polysaccharide that could …

Use Of Gold Nanoparticle-Silibinin Conjugates: A Novel Approach Against Lung Cancer Cells, Rangnath Ravi, Md Zeyaullah, Shubhrima Ghosh, Mohiuddin Khan Warsi, Renu Baweja, Abdullah M. Alshahrani, Abhijeet Mishra, Razi Ahmad

Research Outputs: 2025-Present

Lung cancer presents one of the most challenging carcinomas with meager 5-year survival rates (less than 20%), high metastasis and high recurrence due to chemo- and radio- resistance. An alternative or complementation to existing prognosis modalities is the use of phytochemicals such as silibinin, which targets essential cytokines, angiogenic factors and transcription factors for a profound anti-tumor effect. However, the problems of low solubility in an aqueous physiological environment, poor penetration, high metabolism and rapid systemic clearance limit the therapeutic use of silibinin. Conjugation of gold nanoparticles (GNPs) with silibinin may overcome the above challenges along with distinct advantages of …

Public Health Burden Of Secondhand Smoking: Case Reports Of Lung Cancer And A Literature Review, Ladislav Štěpánek, Jarmila Ševčíková, Dagmar Horáková, Mihir Sanjay Patel, Radka Durďáková

Faculty, Staff and Student Publications

Secondhand smoke (SHS), composed of mainstream and sidestream smoke, is a known human carcinogen. It contains a variety of harmful substances at even higher concentrations than mainstream smoke itself, which is inhaled during firsthand smoking. Exposure to SHS, affecting more than a third of the worldwide population, increases the likelihood of lung cancer by roughly 30%, with specific contributions depending on the histological type of cancer. This study aimed to present the harmful potential of SHS through case reports and describe the burden of SHS via a literature review. From a collection of lung cancer case reports occurring in never …

Kenyon Collegian - October 13, 2022

The Kenyon Collegian

No abstract provided.

Structural And Functional Diversity Of Type Iv Secretion Systems, Melissa R Cruz, Shane Cristy, Shantanu Guha, Giuseppe Buda De Cesare, Elena Evdokimova, Hiram Sanchez, Dominika Borek, Pedro Miramón, Junko Yano, Paul L Fidel, Alexei Savchenko, David R Andes, Peter J Stogios, Michael C Lorenz, Danielle A Garsin

Faculty, Staff and Student Publications

Fungal pathogens are a continuing challenge due to few effective antifungals and a rise in resistance. In previous work, we described the inhibition of Candida albicans virulence following exposure to the 68 amino acid bacteriocin, EntV, secreted by Enterococcus faecalis. Here, to optimize EntV as a potential therapeutic and better understand its antifungal features, an X-ray structure is obtained. The structure consists of six alpha helices enclosing a seventh 16 amino acid helix (α7). The individual helices are tested for antifungal activity using in vitro and nematode infection assays. Interestingly, α7 retains antifungal, but not antibacterial activity and is also …

Impact Of Fruit And Vegetable Protein Vs. Milk Protein On Metabolic Control Of Children With Phenylketonuria: A Randomized Crossover Controlled Trial, Alex Pinto, Anne Daly, Júlio César Rocha, Catherine Ashmore, Sharon Evans, Richard Jackson, Anne Payne, Mary Hickson, Anita Macdonald

School of Health Professions

Fruits and vegetables containing phenylalanine ≤ 75 mg/100 g (except potatoes) have little impact on blood phenylalanine in phenylketonuria (PKU). In a randomized, controlled, crossover intervention trial, we examined the effect of increasing phenylalanine intake from fruits and vegetables, containing phenylalanine 76–100 mg /100 g, compared with milk protein sources on blood phenylalanine control. This was a five-phase study (4 weeks each phase). In Phase A, patients remained on their usual diet and then were randomly allocated to start Phase B and C (an additional phenylalanine intake of 50 mg/day, then 100 mg from fruits and vegetables containing phenylalanine 76–100 …

2022 Practice Recommendation Updates From The World Consensus Conference On Bia-Alcl, Fabio Santanelli Di Pompeo, Mark W Clemens, Michael Atlan, Giovanni Botti, Peter G Cordeiro, Daphne De Jong, Arianna Di Napoli, Dennis Hammond, Cara L Haymaker, Steven M Horwitz, Kelly Hunt, Peter Lennox, Patrick Mallucci, Roberto N Miranda, Alexandre M Munhoz, Eric Swanson, Suzanne D Turner, Guido Firmani, Michail Sorotos

Faculty, Staff and Student Publications

BACKGROUND: Laboratory and clinical research on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is rapidly evolving. Changes in standard of care and insights into best practice were recently presented at the 3rd World Consensus Conference on BIA-ALCL.

OBJECTIVES: The authors sought to provide practice recommendations from a consensus of experts, supplemented with a literature review regarding epidemiology, etiology, pathogenesis, diagnosis, treatment, socio-psychological aspects, and international authority guidance.

METHODS: A literature search of all manuscripts between 1997 and August 2021 for the above areas of BIA-ALCL was conducted with the PubMed database. Manuscripts in different languages, on non-human subjects, and/or discussing …

Mendelian Gene Identification Through Mouse Embryo Viability Screening, Pilar Cacheiro, Carl Henrik Westerberg, Jesse Mager, Mary E Dickinson, Lauryl M J Nutter, Violeta Muñoz-Fuentes, Chih-Wei Hsu, Ignatia B Van Den Veyver, Ann M Flenniken, Colin Mckerlie, Stephen A Murray, Lydia Teboul, Jason D Heaney, K C Kent Lloyd, Louise Lanoue, Robert E Braun, Jacqueline K White, Amie K Creighton, Valerie Laurin, Ruolin Guo, Dawei Qu, Sara Wells, James Cleak, Rosie Bunton-Stasyshyn, Michelle Stewart, Jackie Harrisson, Jeremy Mason, Hamed Haseli Mashhadi, Helen Parkinson, Ann-Marie Mallon, Damian Smedley

Center for Medical Ethics and Health Policy Staff Publications

Background: The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is particularly challenging and strategies combining gene functional evidence with approaches that evaluate the phenotypic similarities between patients and model organisms have proven successful. A full spectrum of intolerance to loss-of-function variation has been previously described, providing evidence that gene essentiality should not be considered as a simple and fixed binary property.

Methods: Here we further dissected this spectrum by assessing the embryonic stage at which homozygous …

Transgender Children’S Books In The Public Library, Tom R. Taylor

Kansas LGBTQ+ Leadership Symposium

In 2019-2020 the Andover Public Library received book challenges on three books in the children’s collection featuring transgender main characters, George by Alex Gino, Lily and Dunkin by Donna Gephart and I am Jazz by Jessica Herthel and Jazz Jennings. The Library Board rejected the challenges and the books remain in the children’s collections. This presentation will share the story of the challenges and all that transpired, including media attention and a protest. It will demonstrate how the director and the library board rejected the book challenges. This specific example demonstrates some of the best practices for facing book challenges …

Fall 2022 Full Issue, Office Of Undergraduate Research

PANDION: The Osprey Journal of Research and Ideas

Full Fall 2022 issue of the Pandion Journal, volume 3, issue 1.

Reanalysis Of The Yunnan Population Of Scorpiops Kubani With A Description Of A New Species, Scorpiops Lowei Sp. N. (Scorpiones: Scorpiopidae), Victoria Tang

Euscorpius

The Yunnan population of Scorpiops kubani (Kovařík, 2004) is reassessed based on recently collected specimens from this region. A misidentification of that species is revealed, which leads to a description of a new species, Scorpiops lowei sp. n.

Demons & Droids: Nonhuman Animals On Trial, Gerrit D. White

PANDION: The Osprey Journal of Research and Ideas

Nonhuman animal trials are ridiculous to the modern sensibilities of the West. The concept of them is in opposition to the idea of nonhuman animals—entities without agency, incapable of guilt by nature of irrationality. This way of viewing nonhuman animals is relatively new to the Western mind. Putting nonhuman animals on trial has only become unacceptable in the past few centuries. Before this shift, nonhuman animal trials existed as methods of communities policing themselves. More than that, these trials were part of legal systems ensuring they provided justice for all. This shift happened because the relationship between Christian authorities and …

Creating The Cultural “Other”: Ableism, Racism, And Imperialism In The 19th And 20th Centuries, Stephanie Baskin

PANDION: The Osprey Journal of Research and Ideas

This project argues that disability and physical difference were simultaneously both sensationalized and hidden in the United States and the United Kingdom, while also being overemphasized in non-Western countries, with the intention of evoking either revulsion, a sense of racial superiority, or pity, all of which was used as justification for Western imperialism. In order to make this argument, the project looks at varying attitudes and actions toward the disabled, physically different, and visibly ill in the U.K. and U.S.A., as well as the varying attitudes and actions toward the disabled, physically different, and visibly ill in the broader imperial …

Ngly1 Deficiency Affects Glycosaminoglycan Biosynthesis And Wnt Signaling Pathway In Mice, Amy Batten

PANDION: The Osprey Journal of Research and Ideas

Individuals affected by NGLY1 Deficiency cannot properly deglycosylate and recycle certain proteins. Even though less than 100 people worldwide have been diagnosed with this rare autosomal recessive condition, thousands are affected by similar glycosylation disorders. Common phenotypic manifestations of NGLY1 Deficiency include severe neural and intellectual delay, impaired muscle and liver function, and seizures that may become intractable. Very little is currently known about the various mechanisms through which NGLY1 deficiency affects the body and this has led to a lack of viable treatment options for those afflicted. This experiment uses a loss-of-function (LOF) mouse model of NGLY1 Deficiency homologous …

Committee On Academic Standing Minutes October 12, 2022, Bronx Community College Committee On Academic Standing

BCC Governance Archives

Minutes for the meeting of the Committee on Academic Standing on October 12, 2022.

The Current - Volume 33 Issue 1, Nova Southeastern University

Student Newspapers

No abstract provided.

The Parthenon, October 12, 2022, Tyler Spence, Evan Green, Connor Woodruff, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Abby Hanlon

The Parthenon

No abstract provided.

Alu Dimorphism At The Pv92 Locus Of Chromosome 16 Is In Equilibrium For University Student Population, James M. Brooks, Mackenzie L. Thackston

Journal of the South Carolina Academy of Science

Alu is a retrotransposable element, which refers to its ability to be copied and move from one region of DNA to another DNA region. At the PV92 locus of chromosome 16, Alu is a 300 bp dimorphic insert that can either be present or absent. It does not encode a protein product and has lost the ability to transpose. It is specific to humans, and differences in genotype and allele frequencies between human populations are important tools in understanding evolution. In this research, data was obtained and analyzed from 269 students at Charleston Southern University (CSU) belonging to four different …

Environmental Bacteriophage Detection On Coastal Carolina University Campus, Madison Gentilo, Hailey Oldfield, Gavin Ockert, Paul E. Richardson

Journal of the South Carolina Academy of Science

Bacteriophages are viruses that infect bacteria. These viruses are found ubiquitously in the environment and are more abundant than any living organism on Earth, including bacteria. Eleven sites are designated for weekly sample collection on the campus of Coastal Carolina University. Water samples are filtered and amplified using strains of E. coli B and E. coli K12 to allow potential coliphages in the sample to proliferate to detectable levels. Plaque assays are used as a microbial screen for the presence of bacteriophage. Samples that test positively using the microbial test are analyzed through a molecular test using PCR to identify …

Collaborative Constructions: Designing High School History Curriculum With The Lost & Found Game Series, Owen Gottlieb, Shawn Clybor

Articles

This chapter addresses design research and iterative curriculum design for the Lost & Found games series. The Lost & Found card-to-mobile series is set in Fustat (Old Cairo) in the twelfth century and focuses on religious laws of the period. The first two games focus on Moses Maimonides’ Mishneh Torah, a key Jewish law code. A new expansion module which was in development at the time of the fieldwork described in this article that introduces Islamic laws of the period, and a mobile prototype of the initial strategy game has been developed with support National Endowment for the Humanities. The …

2022-10-12 Ethics And Art: Ai’S New Horizon, Liv Thurman Saunders

The Spectator Online

No abstract provided.

Association Of Melatonin And Glutathione Peroxidase Enzyme In Patients With Type 2 Diabetes Mellitus, Noor Mohammed Obaid, Zinah Abd Ulelah Abd Ali

Muthanna Medical Journal

Diabetes mellitus (DM) is a group of diseases characterized by high blood glucose levels resulting from a defect in the body's ability to produce and/or use insulin. It is believed that oxidative stress plays important role in the development of vascular complications in type 2 diabetes. The objectives: to determine the serum concentrations of endogenous melatonin and glutathione peroxidase (GPx) in cases of Type 2 DM and compare it with normal controls and to assess the correlation between melatonin and GPx. A case control study was done on 70 patients with diabetes mellitus type 2 according to ADA definition of …

Art. 78 Petition - Fusl000147 (2021-12-13)

Art. 78 Petitions

No abstract provided.

Chronic Stress May Disrupt Covariant Fluctuations Of Vitamin D And Cortisol Plasma Levels And Placentome Formation In Pregnant Sheep During The Last Trimester: A Methodological Approach And Preliminary Report, Colin Wakefield

Tower Health Research Day

No abstract provided.