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Stereological Evidence Of Non-Selective Hippocampal Neurodegeneration, Igf-1 Depletion, And Behavioral Deficit Following Short Term Bilateral Adrenalectomy In Wistar Rats, Naserddine Hamadi, Ömür Gülsüm Deniz, Ahlam Said Abi Issa, Azim Ullah Shamsul Islam, Naheed Amir, Saeed Tariq Minhas, Nather Madjid, Fatima Khelifi-Touhami, Süleyman Kaplan, Abdu Adem

All Works

The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in albino rats. Such a model is one of the few noninvasive models for studying neurodegeneration. In the present study, using stereological technique and ultrastructural examination, we aimed to investigate the impact of short-term adrenalectomy (2 weeks) on different hippocampal neuronal populations in Wistar rats. In addition, the underlying mechanism(s) of degeneration in these neurons were investigated by measuring the levels of insulin-like …

Period 2 Regulates Low-Dose Radioprotection Via Per2/Pgsk3Β/Β-Catenin/Per2 Loop, Aris T Alexandrou, Yixin Duan, Shanxiu Xu, Clifford Tepper, Ming Fan, Jason Tang, Jonathan Berg, Wassim Basheer, Tyler Valicenti, Paul F Wilson, Matthew A Coleman, Andrew T Vaughan, Loning Fu, David J Grdina, Jefferey Murley, Aijun Wang, Gayle Woloschak, Jian Jian Li

Faculty, Staff and Students Publications

During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level radiation (LDR). It is unclear, however, if clock proteins participate in signaling LDR radioprotection. Herein, we demonstrate that radiosensitivity is increased in mice with the deficient Period 2 gene (Per2def) due to impaired DNA repair and mitochondrial function in progenitor bone marrow hematopoietic stem cells and monocytes. Per2 induction and radioprotection are also identified in LDR-treated Per2wt mouse cells and in human skin (HK18) and breast (MCF-10A) …

Density And Climate Effects On Age‐Specific Survival And Population Growth: Consequences For Hibernating Mammals, F. J. Combe, R. Juškaitis, R. C. Trout, S. Bird, J. S. Ellis, J. Norrey, N Al‐Fulaij, I. White, W. E. Harris

School of Biological and Marine Sciences

The impact of factors such as density dependence, food availability and weather are known to be important for predicting population change in a wide range of species. However, a challenge in ecology is understanding the contributory and interactive role of these drivers on populations. This is necessary to design effective conservation and management strategies. Using data from long-term studies of five hazel dormouse Muscardinus avellanarius populations in Europe, we tested the relationship between population density and weather and their impact on demographic rates. We used an integrated population modelling approach, estimating age-specific overwinter survival, annual population growth and fecundity rates. …

Use Of An Invertebrate Animal Model (Aplysia Californica) To Develop Novel Neural Interfaces For Neuromodulation, Junqi Zhuo, Jeffrey P. Gill, Michael W. Jenkins, Hillel J. Chiel

Faculty Scholarship

New tools for monitoring and manipulating neural activity have been developed with steadily improving functionality, specificity, and reliability, which are critical both for mapping neural circuits and treating neurological diseases. This review focuses on the use of an invertebrate animal, the marine mollusk Aplysia californica, in the development of novel neurotechniques. We review the basic physiological properties of Aplysia neurons and discuss the specific aspects that make it advantageous for developing novel neural interfaces: First, Aplysia nerves consist only of unmyelinated axons with various diameters, providing a particularly useful model of the unmyelinated C fibers in vertebrates that are known …

Engineering Naturally Occurring Cd7- T Cells For The Immunotherapy Of Hematological Malignancies, Abdullah Freiwan, Jaquelyn T Zoine, Jeremy Chase Crawford, Abishek Vaidya, Stefan A Schattgen, Jacquelyn A Myers, Sagar L Patil, Mahsa Khanlari, Hiroto Inaba, Jeffery M Klco, Charles G Mullighan, Giedre Krenciute, Peter J Chockley, Swati Naik, Deanna M Langfitt, Maksim Mamonkin, Esther A Obeng, Paul G Thomas, Stephen Gottschalk, M Paulina Velasquez

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR) T-cell therapy targeting T-cell acute lymphoblastic leukemia (T-ALL) faces limitations such as antigen selection and limited T-cell persistence. CD7 is an attractive antigen for targeting T-ALL, but overlapping expression on healthy T cells leads to fratricide of CD7-CAR T cells, requiring additional genetic modification. We took advantage of naturally occurring CD7- T cells to generate CD7-CAR (CD7-CARCD7-) T cells. CD7-CARCD7- T cells exhibited a predominantly CD4+ memory phenotype and had significant antitumor activity upon chronic antigen exposure in vitro and in xenograft mouse models. Based on these encouraging results, we next explored the utility of CD7- …

Pests Of Hemp In Utah, Marion Murray, Macahl Evans, Claudia Nischwitz, Austin Taylor, Cody Zesiger

All Current Publications

This guide includes information on insect and disease pests of hemp, organized by pest group. Much of the content is a result of a two-year arthropod and plant disease survey of field-grown hemp operations in northern Utah. Some pests included in this guide were not found in that survey but may be likely to occur in the future. Beneficials and natural enemies are also covered, and information on pesticides is included.

Editorial - Sure Journal Vol 4, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

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The Interaction Of Adipose Derived Stem Cells And Breast Cancer, Natasha Cunningham, Ava O'Meara, Cathy L. Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: Mesenchymal stem cells are adult stem cells capable of self-renewal and multilineage differentiation (Schweizer et al., 2015). Adipose derived stem cells have been used in breast reconstruction following surgical intervention in breast cancer patients. MicroRNAs have been linked to gene regulation essential in oncogenic, and tumour suppression as well as cell signalling pathways in BC.

Aim: To research the hypothesis of ADSCs and their therapeutic properties in BC patients.

Methods: Proliferation assays were carried out to demonstrate how ADSC conditioned media influenced BC cell lines MDA-MB-231, SKBR3, and T47D. The expression of six miRNAs (miR-21, miR-133, miR-222, miR-146, miR-221, …

An Evaluation Of The Enjoyment Levels Of Participants Of Lifelab, A Health Literacy Intervention For Socially Disadvantaged Adolescents., Lorna Burke, Dr. Hannah Goss, Craig Smith, Dr. Johann Issartel, Dr. Sarahjane Belton

SURE Journal: Science Undergraduate Research Experience Journal

Aim: LifeLab is co-designed by and for Junior Cycle students from social disadvantage in Ireland, with the hope to improve health literacy and subsequent health outcomes in this cohort. The aim of this study was to evaluate the enjoyment levels of students participating in the pilot of LifeLab, with a view to informing future development of the intervention.

Method: As part of the process evaluation of the pilot of LifeLab, a series of focus groups and purposively designed enjoyment scales were completed by 80 adolescents, from one disadvantaged school in Dublin, Ireland. Inductive thematic analysis was carried out to analyse …

Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill

SURE Journal: Science Undergraduate Research Experience Journal

Mitochondria are cytoplasmic, double-membrane organelles that synthesise adenosine triphosphate (ATP). Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. These complexes form a chain that allows the passage of electrons down the electron transport chain (ETC) through a proton motive force, creating ATP from adenosine diphosphate (ADP). This study aims to explore current and prospective therapies for mitochondrial disorders (MTDS). MTDS are clinical syndromes coupled with abnormalities …

Anthelmintic Resistance In Sheep Across Ireland And The Uk: A Literature Review Of The In Vivo Versus In Vitro Methods, Megan Tumulty

SURE Journal: Science Undergraduate Research Experience Journal

Background: The animal welfare and production consequences of gastrointestinal nematode infections, namely Nematodirus battus, on sheep are compelling. The control of gastrointestinal infections has been heavily reliant on the administration of anthelmintics since their introduction into mainstream use in 1960. However, their frequent and often excessive use has resulted in anthelmintic resistance being reported extensively in several gastrointestinal nematode species. The prevalence of anthelmintic resistance as well as the increase in the number of cases of multiple-drug resistance in nematode populations now poses substantial hindrance on the viability of sheep production systems. However, despite the threat N. battus poses …

E.E. Cummings’ Fluid “Objectivity”: A Deep Ecological Response To Michael Webster’S “The New Nature Poetry And The Old”, Etienne Terblanche

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

Three Poets, Gerald Locklin, Tricia Cherlin, Christopher Mulrooney

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

The Pragmatism Of Anyone, Paul Headrick

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

The Weight Of Tradition: Adynata And The "World Upside Down" In The Poetcy Of E. E. Cummings, Antonio Ruiz

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

"Metaphors Copulate In Laughter": Humor In Cummings' Poetry, Claudia Desblaches

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

Some Notes On Classical Meter, Technique, And Cummings' Innovations In 1x1, Robert Dorsett

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

E.E. Cummings- A Centennial Panel Discusssion

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

The Book Of Delights By Ross Gay, Ada Vilageliu-Diaz

Critical Humanities

The Book of Delights by Ross Gay is a collection of journal entries written in a single year. The book starts with the author’s birthday and ends full circle with his next birthday.

One-Week Inquiry About Gravity Force With A Student Who Is Blind, Mustafa Şahin Bülbül Dr.

Journal of Science Education for Students with Disabilities

This study was conducted with a student who is visually impaired and questioned the force of gravity. The different stages encountered in the process were specified as steps in the study and it was shared what kind of inquiry form was needed at each step. There are different activities such as waiting for a week and thought experiment in the inquiry activity. The basis of the activity is that three balls of different mass left on a sponge leave different traces on the sponge.

Case Study: Abnormal Presentation Of Infective Endocarditis With Streptococcus Canis And Chiari Network, Shahbaz Afzal, Ryan Russell, Alexander Chekhov

Advances in Clinical Medical Research and Healthcare Delivery

Here we present a rare case of infective endocarditis (IE) with Streptococcus canis and Chiari network in an 85 year old female living with multiple dogs and open skin of lower extremity predisposing her to bacteremia. Underlying abnormalities of the cardiac chambers such as Chiari network predisposes to a higher incidence of bacterial seeding and causing IE. A Chiari network is usually asymptomatic and of no clinical significance but can worsen prognosis in IE. IE carries a significant morbidity and mortality burden and when diagnosed early can be a lifesaving diagnosis. Due to the wide range of complications, early diagnosis …

Mystery Rash: Atypical Presentation Of Suspected Cat-Scratch Disease In Primary Care, Nicole Hunter, Rutwik Pradeep Sharma, Omobolanle Adetimehin, Yasir Loai

Advances in Clinical Medical Research and Healthcare Delivery

No abstract provided.

Comparison Of Pregnancy Complication Rates: Does Opioid Agonist Pharmacotherapy Make A Difference?, Alexa Pfeiffer Oms-Iii, Michael Falcone Oms-Iii, Pritha Aggarwal Oms-Iii, Andrea M. Bodine Md

Advances in Clinical Medical Research and Healthcare Delivery

Background: Over the past decade, the prevalence of opioid use disorder (OUD) in pregnant patients has increased by 131% with an associated increase in pregnancy complications. Opioid agonist pharmacotherapy (OAP) with methadone or buprenorphine is recommended by ACOG for the management of OUD. The objectives of our study are to compare the incidence of pregnancy complications among patients who at the time of their delivery used OAP, OAP plus any additional substance (OAP+), illicit or prescribed opioids, and no opioids.

Methods: We conducted a retrospective cohort study at Berkshire Medical Center in Pittsfield, MA, between January 1, 2018, through December …

"Regarding Animals" By Arnold Arluke, Clinton R. Sanders, And Leslie Irvine, Andrew Rowan

Tales of WellBeing

The new edition of Regarding Animals is an update of a modern classic on the sociology of human-animal interactions.

The Long Journey Home For The Holidays, Kathleen Rowan, Andrew Rowan

Tales of WellBeing

The Ukraine war threatens animals in zoos. Read about the journey for eleven lions from Ukraine to new homes in the United States and South Africa.

Overqualified And Underrepresented: Gender Inequality In Pharmaceutical Patent Law, S. Sean Tu, Paul R. Gugliuzza, Amy Semet

Journal Articles

Pharmaceutical patents represent some of the most valuable intellectual property assets in the world: they can be worth billions of dollars if courts uphold their validity and find them infringed. But, if invalidated, generic drug manufacturers can get to market earlier, generating billions of dollars of revenue for themselves and creating enormous savings for consumers. Accordingly, drug patents are the product of careful, high-cost prosecution and are associated with high-stakes, bet-the-company litigation. But women lawyers are noticeably absent from pharmaceutical patent practice. This article reports an original empirical study finding that women comprise only one-third of the top pharmaceutical patent …

The Feminization Of Mexico City In The Late Twentieth Century: Polvo De Gallina Negra, Pola Weiss, And Lourdes Grobet, Alexis N. Corral

Theses and Dissertations

This thesis centers on select artworks in public intervention, photography and video as an exploration of female's relationship to Mexico City's social landscape and urban space during the late 1970s into the early 1990s. In three case studies, I explore historical urban planning, gender relations, and the effects of modernization.

Exploring Relationships Between Dog Training Approaches And Aggression, Fear, And Dog-Owner Relationship, Janee Wise

Theses and Dissertations

Abstract

The current study examined relationships between operant conditioning derived dog training techniques and aggression, fear, and dog-owner relationship. Participants (N = 326) completed two online surveys; 1) a survey created for this study measuring the frequency of use of 14 common dog training techniques, which were grouped into four categories based upon operant conditioning: positive reinforcement, negative punishment, positive punishment, and negative reinforcement and 2) the Canine Behavioral Assessment and Research Questionnaire (C-BARQ), which measured several factors related to dog behavior. There were no statistically significant results related to the use of positive reinforcement or positive punishment. However, dog …

Nikki S. Lee’S Self-Stereotyping And Refiguring Cultural Stereotypes, Somi Lee

Theses and Dissertations

This thesis examines a Korean Conceptual photographer, Nikki S. Lee’s performative photographs and film in the series of Projects (1998-2001) and Parts (2002-2005). Through a theoretical analysis of her self-representation in disguise, my research explores established Western stereotypes as well as the artist’s fluid identity in relation to other cultures.

The Negative Effects Of Arbitration Clauses In Meal Delivery Service Subscriptions, Amanda Pasternak

Cardozo Journal of Conflict Resolution (CJCR) Blog

This past June, Daily Harvest, a vegan meal delivery service that sells soups, smoothies, and more recalled one of its products, French Lentil + Leek Crumbles, after hundreds of consumer reports of gastrointestinal illness, potential liver function issues, and other adverse reactions. According to the Food and Drug Administration (FDA), from April 28 to June 17, 2022, around 28,000 units of the recalled product were distributed to consumers throughout the United States via online sales, direct delivery, and retail sales. Samples were also given to a small number of consumers. Daily Harvest received around 470 reports of illness, which the …