Digital Commons Network^™

Emulating Future Neurotechnology Using Magic, Jay A. Olson, Mariève Cyr, Despina Z. Artenie, Thomas Strandberg, Lars Hall, Matthew L. Tompkins, Amir Raz, Petter Johansson

Psychology Faculty Articles and Research

Recent developments in neuroscience and artificial intelligence have allowed machines to decode mental processes with growing accuracy. Neuroethicists have speculated that perfecting these technologies may result in reactions ranging from an invasion of privacy to an increase in self-understanding. Yet, evaluating these predictions is difficult given that people are poor at forecasting their reactions. To address this, we developed a paradigm using elements of performance magic to emulate future neurotechnologies. We led 59 participants to believe that a (sham) neurotechnological machine could infer their preferences, detect their errors, and reveal their deep-seated attitudes. The machine gave participants randomly assigned positive …

Control Of Sars-Cov-2 Infection By Mt1-Mmp-Mediated Shedding Of Ace2, Xuanming Guo, Jianli Cao, Jian-Piao Cai, Jiayan Wu, Jiangang Huang, Pallavi Asthana, Sheung Kin Ken Wong, Zi-Wei Ye, Susma Gurung, Yijing Zhang, Sheng Wang, Zening Wang, Xin Ge, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Nathalie Wong, Jiandong Huang, Zhongjun Zhou, Zhao-Xiang Bian, Shuofeng Yuan, Hoi Leong Xavier Wong

Faculty, Staff and Student Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate a shed soluble form (solACE2) that mediates SARS-CoV-2 entry via receptor-mediated endocytosis. Currently, it is not known how the physiological regulation of ACE2 shedding contributes to the etiology of COVID-19 in vivo. The present study identifies Membrane-type 1 Matrix Metalloproteinase (MT1-MMP) as a critical host protease for solACE2-mediated SARS-CoV-2 infection. SARS-CoV-2 infection leads to increased activation of MT1-MMP that is colocalized with ACE2 in human lung …

Behavioral Strategies Of Prehistoric And Historic Children From Dental Microwear Texture Analysis, Almudena Estalrrich, Kristin L. Krueger

Anthropology: Faculty Publications and Other Works

Reconstructing the dietary and behavioral strategies of our hominin ancestors is crucial to understanding their evolution, adaptation, and overall way of life. Teeth in general, and dental microwear specifically, provide a means to examine these strategies, with posterior teeth well positioned to tell us about diet, and anterior teeth helping us examine non-dietary tooth-use behaviors. Past research predominantly focused on strategies of adult individuals, leaving us to wonder the role children may have played in the community at large. Here we begin to address this by analyzing prehistoric and historic children through dental microwear texture analysis of deciduous anterior teeth.

Proximity-Dependent Biotin Labeling In Testicular Germ Cells Identified Tesmin-Associated Proteins, Seiya Oura, Akinori Ninomiya, Fuminori Sugihara, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Characterization of protein-protein interactions (PPI) is a key to understanding the functions of proteins of interest. Recently developed proximity-dependent biotin identification (BioID) has been actively investigated as an alternative PPI mapping method because of its usefulness in uncovering transient PPI. Here, as an example of proximity labeling proteomics application in the testis, we generated two transgenic mouse lines expressing two biotin ligases (BioID2 or TurboID) fused with TESMIN, which translocates from the cytosol to the nucleus during meiotic progression and is required for reproduction. The BioID2 transgene, albeit not the TurboID transgene, rescued fertility defects of the Tesmin KO male …

Trem2 Dependent And Independent Functions Of Microglia In Alzheimer's Disease, Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonna

2020-Current year OA Pubs

Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia …

Prognostic Factors For Mortality Of Pediatric Burn Injury In A National Tertiary Referral Center, Heru Angkoso, Aria Kekalih

The New Ropanasuri Journal of Surgery

Introduction. In Indonesia, burn injuries cause about 195,000 deaths annually. Data from the Ministry of the Health Republic of Indonesia showed the incidence of burns predominated at 1-4 years old. The mortality of pediatric burn patients in a tertiary hospital was 37.26%. This study aimed to find an association between known and unknown prognostic factors of mortality in Indonesian-specific characteristics.

Method. A retrospective analytical study included all pediatric burns admitted to Dr. Cipto Mangunkusumo General Hospital (CMGH) from 1998 to 2010. Variables within a period of the first 72 hours of admission were the focus of interest and were extracted …

Who Is At The Manger?, Kayla Harris, Neomi Deanda

Marian Library Faculty Publications

For many Christians around the world, celebrating the Nativity, or the birth of Jesus Christ, is the most important part of the Christmas season.

Among the most common Christmas traditions are small sets of figures depicting Joseph, Mary and Jesus that are displayed in individual homes, and live reenactments of the manger scene in communities and churches. While Nativity sets focus on the holy family, they can also include an angel, the three wise men bringing gifts, shepherds or some barnyard animals.

Around the world, it is common to see particular cultural and religious traditions incorporated through the materials used, …

Investigation Of Healthcare Providers Beliefs, Confidence, Knowledge, And Prevelance Within Practice Of Medicinal Cannabinoids And The Endocannabinoid System: Pre And Post Educational Intervention, Kelcey O'Daniel

Doctor of Nursing Practice Scholarly Project

The purpose of this scholarly project was to assess healthcare providers’ knowledge, and confidence of the endocannabinoid system, medicinal cannabinoids, and the action of Cannabidiol (CBD) prior to, and after an educational delivery. The surveys and educational intervention were distributed by social media platforms to healthcare providers and students of the qualifying professions to gain insight on current confidence, knowledge, and prevalence when it comes to medicinal cannabinoid discussion within healthcare practice. Results yielded statistically significant results in a multitude of aspects. When running paired samples correlations, each category within the investigation into provider confidence, proved to be statistically significant …

Heat Stressed Exercise Elicits Shifts In Cooling Strategies Across Body Mass In Tropical Songbirds, Kristen Dee Oliver

Biology ETDs

In resting animals, water use positively correlates with metabolic rate, for example smaller animals using proportionally more water per gram of body mass. However, animals also must endure heat and exertion, and evaporative cooling requires additional water use that may not scale similarly with body size. How evaporative water loss allometrically scales with body mass during heat-stressed exercise is poorly resolved, particularly for birds, yet is critically important for understanding the consequences of climate warming on the fitness of bird populations. Here, we evaluated how air temperature (T_a) influenced evaporative water loss during exercise (EWL_exercise) across …

Fargo Moorhead Ballet To Perform Jan. 28, Communications And Marketing

Campus News Archive

No abstract provided.

Grendel's Mother, Zoe M. Lasden-Lyman

Theses and Dissertations

She helps all the humans and animals in her building. Then why won't she answer this strange, new knocking at her apartment door? A bizarre thriller about the world right now... and about cats.

Verge: A Collection Of Poems, Alexandria Machado

Master’s Theses and Projects

No abstract provided.

“Cuando Crezca, Quiero Ser Fotógrafo”: Caminos De La Producción Audiovisual De Kamikia Kisêdjê, Rodrigo Lacerda, Ximena Flores Rojas, Tatiane Maíra Klein

Tipití: Journal of the Society for the Anthropology of Lowland South America

Entrevista con Kamikia Kisêdjê.

Reindeer From Alaska Are Brought To Sun Valley, John W. Lundin

Works by Local Authors

No abstract provided.

Niche Modeling Of Eight Crayfish Species In Texas, Nathan Schubert

Biology Theses

Freshwater species make up ~10% of all known species and occupy less than one percent of earth’s habitat, which is being degraded by human usage. Crayfish have a large impact on their aquatic or terrestrial environment and can serve as a health indicator of aquatic environments, as they generally require undegraded environments. In many habitats, crayfish make up more than half of the macroinvertebrate biomass, and play important ecological roles, as a food resource for both aquatic and terrestrial species, as predators of fish and invertebrates, and as bioprocessors of vegetation and detritus. The objective of this project was to …

Movements In C Minor: Vocal Soundscapes In Eastern Amazonia (Araweté), Guilherme Orlandini Heurich

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article examines the capture of forest spirits through music in the Anĩ pihi speech-songs of the Araweté, a small Amerindian society in Eastern Amazonia, Brazil. The Anĩ pihi are unique in their combination of spoken and sung forms, in which spirits and divinities are voiced by a ritual specialist. I explore how particular sounds index the presence of different kinds of others (gods and spirits), and how these sounds are, in turn, related to the use of reported speech – in other words, how others talk about other others in sung form. As such, the Anĩ pihi are a …

The Long Teeth Of Memory, Darren Alan Heil

English Theses, Dissertations, and Student Creative Activity

The Long Teeth of Memory is a collection of contemporary short stories, personal essays, and poetry. All the work incorporates elements of the author’s life. Where the stories are wholly autobiographical, the character Jeff Holden (an avatar for the author) appears, alongside his ex-wife (Carla), children (Megan, Samantha, and George), and former brother-in-law (Mark). Fictional stories are presented as bylined by Jeff Holden.

Myocardial Contractility Pattern Characterization In Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study With Contractix, El-Sayed H Ibrahim, Antonio Sosa, Sherry-Ann Brown, Dayeong An, Slade Klawikowski, John Baker, Carmen Bergom

2020-Current year OA Pubs

Radiation therapy (RT) plays an integral role in treating thoracic cancers, despite the risk of radiation-induced cardiotoxicity. We hypothesize that our newly developed magnetic resonance imaging (MRI)-based contractility index (ContractiX) is a sensitive marker for early detection of RT-induced cardiotoxicity in a preclinical rat model of thoracic cancer RT. Adult salt-sensitive rats received image-guided heart RT and were imaged with MRI at 8 weeks and 10 weeks post-RT or sham. The MRI exam included cine and tagging sequences to measure left-ventricular ejection fraction (LVEF), mass, myocardial strain, and ContractiX. Furthermore, ventricular torsion, diastolic strain rate, and mechanical dyssynchrony were measured. …

Walter Scott, The Two Sicilies, And Events ‘Of Recent Date’, Graham Tulloch

Studies in Scottish Literature

Traces Walter Scott's interest in Sicily and Naples through his earlier writing up to his travels to both in 1831-1832, discusses his treatment of Neapolitan history and politics in essays in 1816 and 1829, especially his accounts of Joachim Murat (1767-1815), king of Naples from 1808-1815, and in Masaniello, leader of the popular rising in 1647-48, and suggests how these interests connect to Scott's unfinished short novel Bizarro, written in 1832 but first published in 2008, so unavailable to earlier Scott scholars.

Scott’S Reparative Land Ethic, Nigel Leask

Studies in Scottish Literature

A review essay discussing Susan Oliver's "important and convincing" book Walter Scott and the Greening of Scotland: Emergent Ecologies of a Nation (Cambridge University Press, 2021), noting Scott's land ethic and active role in managing his estate at Abbotsford and in afforestation, and suggesting that Oliver's book presents "a cumulative literary history of Scotland’s ecologies," so that Scott's poetry and novels "assume a new relevance for 21st century readers".

Correlation Of Angiogenic Biomarkers To Tumor Progression And Angiogenesis In Cervical Cancer Cell (Caski)-Implanted Nude Mice, Nakorn Mathuradavong, Umarat Srisawat, Bhornprom Yoysungnoen, Nattapon Sookprasert

Asian Medical Journal and Alternative Medicine

Introduction: Several studies have indicated that microvascular density (MVD) and the expressions of angiogenic biomarkers were associated with tumor growth and angiogenesis in cervical cancer. However, the results were incomplete and inconsistent.

Objectives: To determine the correlation of the angiogenic biomarkers, including vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR), to tumor progression and angiogenesis in cervical cancer cell (CaSki)-implanted nude mice model.

Methods: 10×10⁶ of CaSki cells were injected into the female nude mice (n = 50) to establish subcutaneous tumors. The tumor size was measured every 3 days …

Late-Stage Functionalization Through Click Chemistry Provides Glut5-Targeting Glycoconjugate As A Potential Pet Imaging Probe, Adelina Oronova, Marina Tanasova

Michigan Tech Publications, Part 1

The targeting of facilitative sugar transporters (GLUTs) has been utilized in the development of tools for diagnostics and therapy. The interest in this area is promoted by the phenomenon of alterations in cellular metabolic processes that are linked to multitudes of metabolic disorders and diseases. However, nonspecific targeting (e.g., glucose-transporting GLUTs) leads to a lack of disease detection efficiency. Among GLUTs, GLUT5 stands out as a prominent target for developing specific molecular tools due to its association with metabolic diseases, including cancer. This work reports a non-radiolabeled fluoride (19F) coumarin-based glycoconjugate of 2,5-anhydro-D-mannitol as a potential PET imaging probe that …

Acute Pain Management Pearls: A Focused Review For The Hospital Clinician., Sara J Hyland, Andrea M Wetshtein, Samantha J Grable, Michelle P Jackson

Pharmacy Articles

Acute pain management is a challenging area encountered by inpatient clinicians every day. While patient care is increasingly complex and costly in this realm, the availability of applicable specialists is waning. This narrative review seeks to support diverse hospital-based healthcare providers in refining and updating their acute pain management knowledge base through clinical pearls and point-of-care resources. Practical guidance is provided for the design and adjustment of inpatient multimodal analgesic regimens, including conventional and burgeoning non-opioid and opioid therapies. The importance of customized care plans for patients with preexisting opioid tolerance, chronic pain, or opioid use disorder is emphasized, and …

Predation Of Vertebrates By Domestic Cats In Two Brazilian Hotspots: Incidental Records And Literature Review, Clodoaldo Lopes Assis, Camila Moura Novaes, Marcelo Augusto Pereira Coelho Dias, Jhonny José Magalhães Guedes, Renato Neves Feio, Guilherme Siniciato Terra Garbino

Neotropical Biodiversity

No abstract provided.

A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal

Articles

With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the …

“Quando Eu Crescer, Quero Ser Um Fotógrafo”: Caminhos Da Produção Audiovisual De Kamikia Kisêdjê, Rodrigo Lacerda, Ximena Flores Rojas, Tatiane Maíra Klein

Tipití: Journal of the Society for the Anthropology of Lowland South America

Entrevista com Kamikia Kisêdjê

Bio-Inspired Micromachined Volumetric Flow Sensor With A Big Dynamic Range For Intravenous Systems, Lansheng Zhang, Yingchen Yang, Georgios A. Bertos, Chang Liu, Huan Hu

Mechanical Engineering Faculty Publications

Real-time monitoring of drug delivery in an intravenous infusion system can prevent injury caused by improper drug doses. As the medicine must be administered into the vein at different rates and doses in different people, an ideal intravenous infusion system requires both a low flow rate and large dynamic range monitoring. In this study, a bio-inspired and micromachined volumetric flow sensor is presented for the biomedical application of an intravenous system. This was realized by integrating two sensing units with different sensitivities on one silicon die to achieve a large dynamic range of the volumetric flow rate. The sensor was …

White Matter Correlates Of Domain-Specific Working Memory, Autumn Horne, Junhua Ding, Tatiana T Schnur, Randi C Martin

Faculty, Staff and Student Publications

Prior evidence suggests domain-specific working memory (WM) buffers for maintaining phonological (i.e., speech sound) and semantic (i.e., meaning) information. The phonological WM buffer's proposed location is in the left supramarginal gyrus (SMG), whereas semantic WM has been related to the left inferior frontal gyrus (IFG), the middle frontal gyrus (MFG), and the angular gyrus (AG). However, less is known about the white matter correlates of phonological and semantic WM. We tested 45 individuals with left hemisphere brain damage on single word processing, phonological WM, and semantic WM tasks and obtained T1 and diffusion weighted neuroimaging. Virtual dissections were performed for …

Hif1a-Dependent Induction Of Alveolar Epithelial Pfkfb3 Dampens Acute Lung Injury, Christine U Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K Vladar, Christina Sul, Eric P Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S Nozik, Rubin M Tuder, Holger K Eltzschig

Faculty, Staff and Student Publications

Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar inflammation. We hypothesize that specific enzymes of the glycolytic pathway could function as key regulators of alveolar inflammation. Therefore, we screened isolated alveolar epithelia from mice exposed to ALI induced by injurious ventilation to assess their metabolic responses. These studies pointed us toward a selective role for isoform 3 of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3). Pharmacologic inhibition or genetic deletion of Pfkfb3 in alveolar epithelia (Pfkfb3loxP/loxP SPC-ER-Cre+ mice) was associated with profound increases in ALI during …

Human Health During Space Travel: State-Of-The-Art Review, Chayakrit Krittanawong, Nitin Kumar Singh, Richard A Scheuring, Emmanuel Urquieta, Eric M Bershad, Timothy R Macaulay, Scott Kaplin, Carly Dunn, Stephen F Kry, Thais Russomano, Marc Shepanek, Raymond P Stowe, Andrew W Kirkpatrick, Timothy J Broderick, Jean D Sibonga, Andrew G Lee, Brian E Crucian

Faculty, Staff and Student Publications

The field of human space travel is in the midst of a dramatic revolution. Upcoming missions are looking to push the boundaries of space travel, with plans to travel for longer distances and durations than ever before. Both the National Aeronautics and Space Administration (NASA) and several commercial space companies (e.g., Blue Origin, SpaceX, Virgin Galactic) have already started the process of preparing for long-distance, long-duration space exploration and currently plan to explore inner solar planets (e.g., Mars) by the 2030s. With the emergence of space tourism, space travel has materialized as a potential new, exciting frontier of business, hospitality, …