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2022

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Effects Of Azadirachta Indica Extract On Inhibition Of Glutamate-Induced Neuronal Cell Apoptosis Via Preventing Excessive Mitophagy Activation And Inhibiting Endoplasmic Reticulum Stress In Ht-22 Cells, Kuljira Mongkolpobsin Jan 2022

Effects Of Azadirachta Indica Extract On Inhibition Of Glutamate-Induced Neuronal Cell Apoptosis Via Preventing Excessive Mitophagy Activation And Inhibiting Endoplasmic Reticulum Stress In Ht-22 Cells, Kuljira Mongkolpobsin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Neurodegenerative diseases (NDs) are the age-related diseases which represent a major cause of mortality in aging population nowadays. Previous studies have shown that glutamate, the most abundant excitatory neurotransmitter, significantly increases in extracellular fluid of the patient’s brain and is the cause of neurodegeneration in NDs. The increase of extracellular glutamate elevates reactive oxygen species (ROS) accumulation and calcium (Ca2+) which exacerbate mitochondrial function, followed by inducing MAPK pathway and endoplasmic reticulum (ER) stress, respectively. In addition, Ca2+ overload also triggers calpain, a Ca2+ dependent protease, activity which further stimulates Cdk5/p35/p25 signaling leading to neuronal apoptosis. Azadirachta indica A. Juss. …

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Perceived Image Of Samui Island From Local Stakeholders, Ponatip Phetrat Jan 2022

Perceived Image Of Samui Island From Local Stakeholders, Ponatip Phetrat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this research was to explore the perceived image of Samui island from local stakeholders. An in-depth interview was selected as the research instrument for this study. The data is collected from 15 respondents who were local stakeholders of Samui island, they are those who live and work in Samui for more than 10 years, aged between 24-45 years old. The findings indicated that according to brand associations in terms of attributes the respondents perceived Samui island as “beach” “nature” and “cultural tourist destination” also, respondents perceived Samui as having “friendly” “lively” “complicated” and “easy-going” personalities. In terms …

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Using Open-Source Software For Business, Urban, And Other Applications Of Deep Neural Networks, Machine Learning, And Data Analytics Tools, Richard S. Segall, Vidhya Sankarasubbu Jan 2022

Using Open-Source Software For Business, Urban, And Other Applications Of Deep Neural Networks, Machine Learning, And Data Analytics Tools, Richard S. Segall, Vidhya Sankarasubbu

Faculty Publications

This article provides an overview with examples of what Neural Networks (NN), Machine Learning (ML), and Artificial Intelligence (AI) and Data Analytics are, and with their applications in business, urban and biomedical situations. The characteristics of 29 types of neural networks are provided including their distinctive graphical illustrations. A survey of current open-source software (OSS) for neural networks, neural network software available for free trial download for limited time use, open-source software (OSS) for Machine Learning (ML), and open-source software (OSS) for Data Analytics tools are provided. Characteristics of Artificial Intelligence (AI) technologies for Machine Learning available as open-source are …

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Animal Sentience Science And Policy, Andrew Crump Jan 2022

Animal Sentience Science And Policy, Andrew Crump

Animal Sentience

Animal sentience research cannot be divorced from its ethical and political implications. For example, discovering which animals are sentient is vital for deciding which require welfare protection. Two legal case-studies illustrate the importance of scientists in such debates: the UK Animal Welfare (Sentience) Act 2022 had input from animal sentience researchers, whereas the US Animal Welfare Act 1966 did not. The former defined sentient animals much more plausibly than the latter. I accordingly argue that sentience researchers should inform policy, and that this is achievable without sacrificing scientific integrity.

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Lack Of Imagination Can Bias Our View Of Animal Sentience, Brian Key, Deborah Brown Jan 2022

Lack Of Imagination Can Bias Our View Of Animal Sentience, Brian Key, Deborah Brown

Animal Sentience

How an animal reacts to a sensory stimulus is often used to assess whether that animal can experience feelings such as pain and pleasure. This behavioural path is typically complemented with reference to how a human would normally respond to and experience an analogous stimulus. Together, these approaches can lead to a “hard to imagine otherwise” argument for feelings. It is time to go beyond these qualitative assessments and to now determine whether a nervous system can execute the neural functions necessary for sentience.

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Random Walks On Quasi-1d Infinite Structures, Srawut Sasom Jan 2022

Random Walks On Quasi-1d Infinite Structures, Srawut Sasom

Chulalongkorn University Theses and Dissertations (Chula ETD)

In the present thesis a random walk on quasi-1d lattices as a model for transport processes on quasi-1d materials is analytically investigated. The scope of the present work is to shed light on the asymptotic behavior of basic statistical properties of the random walk on such structures including the first and the second moments of the walker location along the structure axis, the probability of return to the starting site, the probability of ever reach a given site, the conditional mean first-passage time to a given site and the expected number of distinct sites visited. The first part of the …

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Addressing Rice Waste In University Cafeterias Using Material Flow Analysis And System Dynamics Modeling, Abigail Marie T. Favis, Charlotte Kendra Z. Gotangco-Gonzales, Ana Erika Lareza Jan 2022

Addressing Rice Waste In University Cafeterias Using Material Flow Analysis And System Dynamics Modeling, Abigail Marie T. Favis, Charlotte Kendra Z. Gotangco-Gonzales, Ana Erika Lareza

Environmental Science Faculty Publications

Food waste has emerged as one of the focus areas in sustainability research. At the Ateneo de Manila University, previous studies have found that food waste is composed mainly of rice. This study, therefore, analyzed cafeteria rice systems in the university through a material flow analysis (MFA) to identify key factors for formulating effective rice waste reduction techniques and then applied the results toward developing system dynamics (SD) models as tools for decision-making. The MFA found that the total mass of produced known rice waste was 49.48 kg/d. The largest sources of rice wastes were the upstream processes of the …

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Viola Music Written By Costa Rican Composers: Analysis Of Three Compositional Trends In Costa Rica, Karen Soto Huertas Jan 2022

Viola Music Written By Costa Rican Composers: Analysis Of Three Compositional Trends In Costa Rica, Karen Soto Huertas

Theses and Dissertations--Music

What could come from a country that just this past year celebrated 200 years of independence that was only discovered in 1502 and was under the yoke of the Spanish Empire for over 300 hundred years? What contribution to the art music community could this third-world country, Costa Rica, bring to the table? Specifically, what contributions could Costa Rica make to the viola repertoire, which status as a soloistic instrument was raised only 100 or so years ago? How could a small country contribute to the repertoire of this often-forgotten instrument? To answer these questions, I have embarked on research …

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Momentary Endurance: The Effects Of Mouthpiece Pressure And Capillary Refill Time On Short-Term Muscle Recovery In Trumpet Players, Taylor Gustad Jan 2022

Momentary Endurance: The Effects Of Mouthpiece Pressure And Capillary Refill Time On Short-Term Muscle Recovery In Trumpet Players, Taylor Gustad

Theses and Dissertations--Music

The topic of proper mouthpiece pressure usage has been widely pushed off to the margins of trumpet pedagogy, only receiving the passing mention in a limited number of method books. This research paper contains a cross sectional view of the few, but most prominently used method books in the trumpet community that shows the prevalence of this issue, as well as steps to bring in new and useful information in this field. There are several aspects of mouthpiece pressure that should be studied; however, this paper focuses on its connection to momentary endurance and capillary refill time.

Momentary endurance is …

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Constructing A Cultural Bridge: The Compositional Approach And International Impact Of Albert Mangelsdorff’S Now Jazz Ramwong, Michael Desousa Jan 2022

Constructing A Cultural Bridge: The Compositional Approach And International Impact Of Albert Mangelsdorff’S Now Jazz Ramwong, Michael Desousa

Theses and Dissertations--Music

In the period following World War II, countries such as Japan, Vietnam, and Thailand were under constant intellectual bombardment from global superpowers vying for political influence. West Germany, a newly established ally of Western democracy, was a small part of a global effort to spread this democracy to Asia. Working alongside Joachim-Ernst Berendt and the Goethe Institute, the jazz trombonist Albert Mangelsdorff arranged an album which sought to merge both Western European and Asian music. The album, Now Jazz Ramwong (1964), and accompanying fifty-concert tour helped pioneer a lasting cultural connection between Western Europe and Asia. The methodology behind Now …

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Children’S Dental Fear And Anxiety: Parent Predictions, Perceptions, And Behaviors, Alana Summers-Plotno Jan 2022

Children’S Dental Fear And Anxiety: Parent Predictions, Perceptions, And Behaviors, Alana Summers-Plotno

PCOM Psychology Dissertations

Pediatric dental fear and anxiety is common, yet there is limited research in this area. Childhood dental anxiety may create challenges for children, parents, and dentists. Parents’ dental anxiety may contribute and maintain children’s dental anxiety. This purpose of this study was to explore the relationship between parent and child dental anxiety and parents’ perceptions of their children’s dental anxiety. This study also investigated parent accommodation in relation to children’s dental anxiety, as well as children’s views of their parents’ anxiety. Further, this study examined the relationship between dental procedures and children’s dental anxiety. This cross-sectional study included a total …

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Motivational Cognitive Behavioral Therapy For Dementia Prevention: A Pilot Study To Protect The Brain And Memory, Nicholas Hope Jan 2022

Motivational Cognitive Behavioral Therapy For Dementia Prevention: A Pilot Study To Protect The Brain And Memory, Nicholas Hope

PCOM Psychology Dissertations

This study sought to explore the efficacy of a manualized group therapy protocol developed for this project combining empirically-supported Cognitive Behavioral Therapy (CBT) and Motivational Interviewing (MI), which we coined as Motivational CBT (MI-CBT), adapted for individuals at a heightened risk of cognitive decline in later adulthood. Specifically, this study investigated changes in cognition, adaptive sleep behavior, diet, exercise, depression, anxiety, and dementia knowledge as well as modifiable lifestyle factors such as Body Mass Index (BMI), hypertension, cholesterol, cigarette smoking, and medical adherence. A group of twenty-five participants (N = 25) were recruited in a large Northeastern city from a …

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Complementary And Alternative Medicine Treatment-Related Beliefs In Cannabidiol Users With Generalized Anxiety, Aleta A. Cohn Jan 2022

Complementary And Alternative Medicine Treatment-Related Beliefs In Cannabidiol Users With Generalized Anxiety, Aleta A. Cohn

PCOM Psychology Dissertations

Despite limited research supporting its benefits, adults in the United States commonly use herbal forms of complementary and alternative medicine (CAM) such as cannabidiol (CBD) for anxiety. Little is known about the treatment-related beliefs that may motivate their choice to use CAM. The present study used mixed methods to assess differences in CAM-related treatment beliefs in a sample of adults with generalized anxiety. For a cross-sectional online survey hosted via Research Electronic Data Capture (REDCap), 180 adults were recruited. Generalized anxiety symptoms and severity were assessed using the Generalized Anxiety Disorder 7 (GAD-7) screener. Beliefs about CAM were measured through …

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Demographic And Neurocognitive Predictive Factors Impacting On Expressed Vocational Interests, Tamar Runyan Jan 2022

Demographic And Neurocognitive Predictive Factors Impacting On Expressed Vocational Interests, Tamar Runyan

PCOM Psychology Dissertations

This study examined multiple demographic and neurocognitive variables to determine which ones were predictive of expressed range of occupational interests and occupational interest types. This study used archival data from an outpatient community training clinic that included the Strong Interest Inventory (SII), tests of intellectual functioning, and tests of executive functioning. It was hypothesized that demographic variables (age, gender, years of education, and socioeconomic status) and cognitive variables (intelligence and executive functioning) would be predictive of the expressed range of occupational interests; and that there would be differences in career interests by gender and race/ethnicity. Multiple regressions and chi-square tests …

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Influence Of Beef Carcass Weight On Carcass Chilling, Steak Case Life And Quality Traits, Trevor C. Dehaan Jan 2022

Influence Of Beef Carcass Weight On Carcass Chilling, Steak Case Life And Quality Traits, Trevor C. Dehaan

Electronic Theses and Dissertations

The objective of this thesis was to determine the influence of beef carcass weight on chilling and pH decline of beef carcasses, as well as color, case life and tenderness of steaks from the round, loin, rib and chuck. Twelve carcasses were allotted by hot carcass weight (HCW) into Heavyweight (HW) and Lightweight (LW) groups. Temperature decline, pH decline and thermal image temperature were measured in the round, loin, rib, and chuck for approximately 48 hours. Carcass data including 12th rib fat thickness, ribeye area, and marbling score were collected. The Semitendinosus (ST), Longissimus lumborum (LL), Longissimus thoracis (LT) and …

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Phosphorus Use And Management Based On Fertilizer Placement, Rate Of Application, And Soil Biota In No-Till Situations, Brennan Alexander Bingham Lewis Jan 2022

Phosphorus Use And Management Based On Fertilizer Placement, Rate Of Application, And Soil Biota In No-Till Situations, Brennan Alexander Bingham Lewis

Electronic Theses and Dissertations

Phosphorus (P) pollution has become a concern among multiple scientific organizations as it leads to eutrophication, an algal bloom that depletes lacustrine and marine ecosystems of native species. Multiple strategies can be implemented to reduce phosphorus loss from agriculture fields, which is often implicated as a cause of eutrophication. Soil phosphorus chemistry results in phosphate fertilizers absorbing to clay minerals over time. Soil phosphorus is lost from agricultural fields primarily through wind and water erosion. No-till practices prevent soil erosion, which reduces the phosphorus from loading into waterways. Fertilizer placement affects phosphorus loss. Surface application of phosphorus fertilizers increases the …

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Targeted Browsing With Goats For Eastern Redcedar (Juniperus Virginiana L.) Control, Alanna M. Hartsfield Jan 2022

Targeted Browsing With Goats For Eastern Redcedar (Juniperus Virginiana L.) Control, Alanna M. Hartsfield

Electronic Theses and Dissertations

As eastern redcedar (ERC) (Juniperus virginiana L.) grassland encroachment progresses, all potential control methods should be explored in the interest of Great Plains grassland health and longevity. Targeted browsing with goats has been proven as an effective control method on some juniper species; however, little is known about its ability to control ERC. These studies intend to mend knowledge gaps of how targeted browsing with goats control ERC by causing tree death without chemicals or machinery. The first study is two 3x3 Latin squares comparing protein-supplemented diets. The second study is a randomized complete block design of five 0.224 ha …

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Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli Jan 2022

Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli

Turkish Journal of Biology

Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging …

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Melatonin Ameliorates Cisplatin-Induced Neurodegeneration In Medulla Oblongata Through The Expressions Of Aqp-1,-4, Inflammation And Apoptosis Pathway Genes, Rahi̇me Özlem Öztopuz Jan 2022

Melatonin Ameliorates Cisplatin-Induced Neurodegeneration In Medulla Oblongata Through The Expressions Of Aqp-1,-4, Inflammation And Apoptosis Pathway Genes, Rahi̇me Özlem Öztopuz

Turkish Journal of Biology

In this study, the neuroprotective effects of melatonin (MEL) with changes in apoptosis, inflammation, and histopathological morphology were evaluated in the medulla oblongata of cisplatin (CIS) administered rats. Although the side effects of CIS are known in many tissues, its reaction on the medulla oblongata and the molecular association underlying this effect is unclear. Male wistar albino rats were separated into four groups (control, CIS, CIS+MEL, and MEL) (n = 24). CIS and CIS+MEL groups were given 4 mg/kg CIS at 4-day intervals (days 1, 5, 9, and 13) by the first day of the study. The MEL and CIS+MEL …

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Bone Marrow Mesenchymal Stem Cells Attenuate Lps-Induced Acute Lung Injury In Mice By Promoting Rve1/Prod1 And Modulating Treg/Th17 Balance, He-Bu Qian, Guijuan Zou, Chao Li, Qifang He, Jun Liu Jan 2022

Bone Marrow Mesenchymal Stem Cells Attenuate Lps-Induced Acute Lung Injury In Mice By Promoting Rve1/Prod1 And Modulating Treg/Th17 Balance, He-Bu Qian, Guijuan Zou, Chao Li, Qifang He, Jun Liu

Turkish Journal of Biology

Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are respiratory failures caused by excessive alveolar inflammation with high mortality. In this study, we investigated the effects of bone marrow mesenchymal stem cells (BMSCs) on lung injury of lipopolysaccharide (LPS)-induced ALI and explored the associated mechanisms. BMSCs were isolated, cultured, identified by staining with CD34 and CD44 surface markers. LPS-induced ALI mouse model was generated by injecting with LPS and divided into ALI group and ALI+BMSCs group. Mice treated without any reagents were assigned as Control, mice transplanted with BMSCs were assigned as BMSCs group. Regulatory …

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Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan Jan 2022

Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan

Turkish Journal of Biology

Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …

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Rgs1 Serves As An Anti-Tumor Target To Inhibit Proliferation Of Nicn87-Dr Cells And Tumor Growth In Gastric Cancer Mouse Model, Zhixiong Chen, Banglun Liu, Shouru Zhang, Lihui Chen, Yuyu Lv, Hao Sun Jan 2022

Rgs1 Serves As An Anti-Tumor Target To Inhibit Proliferation Of Nicn87-Dr Cells And Tumor Growth In Gastric Cancer Mouse Model, Zhixiong Chen, Banglun Liu, Shouru Zhang, Lihui Chen, Yuyu Lv, Hao Sun

Turkish Journal of Biology

Gastric cancer is becoming the 4th leading cause of cancer-associated death worldwide. The purpose of this study was to investigate the role of RGS1 in gastric cancer in vitro and in vivo. Proliferation, migration, invasion, and colony formation of NCIN87 cells and drug-resistant NCIN87 cells (NCIN87-DR) were determined. Cell apoptosis and cell cycle were examined using a flow cytometry assay. RGS1 gene knock-down vector (pLVshshRGS1) and Xenograft tumor mouse model was generated. RGS1 and epithelial-mesenchymal transition (EMT) associated markers, including E-cadherin (E-cad), N-cadherin (N-cad), Slug, and Vimentin were detected using a western blotting assay. Tumor size of Xenograft tumor mouse …

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Influence Of Aerobic Exercise Training On Mice Gut Microbiota In Parkinson's Disease, Tianlun Fan, Xiating Li, Xiang Zhang, Jing Zhang, Lichun Sun, Jingjing Chen, Chuan Fu Jan 2022

Influence Of Aerobic Exercise Training On Mice Gut Microbiota In Parkinson's Disease, Tianlun Fan, Xiating Li, Xiang Zhang, Jing Zhang, Lichun Sun, Jingjing Chen, Chuan Fu

Turkish Journal of Biology

Accumulating evidence shows that gut microbial dysbiosis may represent a risk factor for Parkinson's disease (PD). Exercise has a positive effect on microbiota in general. The effect of aerobic exercise training (AET) on the gut microbial environment in PD remains to be explored. Here, we performed the 16S rRNA gene sequencing on feces from sham operated-mice (sham), PD mice model, and mice receiving AET (AET). Results indicated that AET had no remarkable effect on species richness and bacterial diversity of PD mice. The relative abundance of the Bacteroidetes was reduced, while Firmicutes, Actinobacteria, Lactobacillaceae, Streptococcaceae, Lactobacillus, Streptococcus, Lactococcus, Lysinibacillus, Pelomonas, …

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Palmitic Acid Declines Glucose Uptake In Hepg2 Cells Via Modulating Phosphoglucomutase 1 To Repress Phosphatidylinositol 3 Kinase/Protein Kinase B And Jnk Pathways Via Inducing Microrna-124-3p, Linghui Zhang, Shengli Zhang Jan 2022

Palmitic Acid Declines Glucose Uptake In Hepg2 Cells Via Modulating Phosphoglucomutase 1 To Repress Phosphatidylinositol 3 Kinase/Protein Kinase B And Jnk Pathways Via Inducing Microrna-124-3p, Linghui Zhang, Shengli Zhang

Turkish Journal of Biology

Diabetes resulting from insufficient insulin secretion or insulin resistance (IR) is a highly prevalent metabolic disease. Since microRNAs have been linked with elevated IR, the current research hypothesized that miR-124-3p has a role in IR and the establishment of IR and type 2 diabetes (T2DM). The study aimed to explore the molecular mechanisms of miR-124-3p which influence IR leading to T2DM establishment. HepG2 cells were cultured in vitro, and palmitic acid (PA) was used to construct the IR cell model. In the IR model, transfection of miR-124-3p or phosphoglucomutase 1 (PGM1) linked plasmids were transfected into HepG2 cells. RT-qPCR was …

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Demethylase Fto Inhibits The Development Of Prostate Cancer By Upregulating Egr2 Expression In An M6a Manner, Zhenyu Wang, Huami̇n Sun, Hua Zhu, Donghua Gu, Xi̇nfeng Chen, Yongsheng Pan, Bi̇ng Zheng, Dongrong Yang Jan 2022

Demethylase Fto Inhibits The Development Of Prostate Cancer By Upregulating Egr2 Expression In An M6a Manner, Zhenyu Wang, Huami̇n Sun, Hua Zhu, Donghua Gu, Xi̇nfeng Chen, Yongsheng Pan, Bi̇ng Zheng, Dongrong Yang

Turkish Journal of Biology

Fat mass and obesity-associated protein (FTO) is a demethylase and plays a vital role in various cancers. However, the regulation mechanism of FTO in prostate cancer (PCa) remains unclear. This study aimed to elucidate the mechanism of FTO in PCa. The function and mechanism of FTO-mediated in PCa were determined by gain-of-function assays and RNA-seq. We found that FTO expression in PCa tissues and two PCa cell lines were significantly lower than that in adjacent tissues and normal cell line. PCa cells after overexpression of FTO showed a significant lower in proliferation, migration, and invasion capabilities. RNA-seq displayed that FTO …

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Inhibition Of Trpv4 Attenuates Ferroptosis Against Lps-Induced Ali Via Ca2+ Pathway, Junying Cai, Guohai Xu, Yue Lin, Bin Zhou, Zhenzhong Luo, Shuchun Yu, Jun Lu Jan 2022

Inhibition Of Trpv4 Attenuates Ferroptosis Against Lps-Induced Ali Via Ca2+ Pathway, Junying Cai, Guohai Xu, Yue Lin, Bin Zhou, Zhenzhong Luo, Shuchun Yu, Jun Lu

Turkish Journal of Biology

Acute lung injury (ALI) is an inflammation of the lungs with high incidence rate and mortality. Ferroptosis is a new cell death, which has influence in body organs. Transient receptor potential vanillin-4 (TRPV4) channel is a key mediator of Ca2+, its activation induces ferroptosis. The purpose of the study is to investigate the function of TRPV4 on ferroptosis in ALI mice induced by lipopolysaccharide (LPS). In vitro, the regulation of TRPV4 on Ca2+ and ferroptosis was detected by CCK-8, fluorescent probe, and western blot in BEAS-2B cells. In vivo, the role of TRPV4 antagonists on ALI mice …

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Scaffolds From Medical Grade Chitosan: A Good Choice For 3d Cultivation Of Mesenchymal Stem Cells, Merve Çapkin Yurtsever, Özge Eki̇n Akdere, Menemşe Gümüşdereli̇oğlu Jan 2022

Scaffolds From Medical Grade Chitosan: A Good Choice For 3d Cultivation Of Mesenchymal Stem Cells, Merve Çapkin Yurtsever, Özge Eki̇n Akdere, Menemşe Gümüşdereli̇oğlu

Turkish Journal of Biology

Chitosan has high biocompatibility, supports proliferation of many cells, and can be a good carrier for various growth factors. However, low attachment ratio and spheroid formation of several stem cell types on plain chitosan scaffolds/films is still a problem. In this study, it was aimed to obtain 3D scaffolds using medical grade chitosan (MC) with a high deacetylation degree (DD ≥ 92.6%) to overcome the spheroid formation of rat adipose tissue derived mesenchymal stem cells (rAdMSCs) on control chitosan (C, DD = 75%-85%) scaffolds. Genipin was used as a biological chemical crosslinker, and glycerol phosphate salt was used both as …

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Knockdown Of Death Receptor 5 Antisense Long Noncoding Rna And Cisplatin Treatment Modulate Similar Macromolecular And Metabolic Changes In Hela Cells, Di̇lek Cansu Gürer, İpek Erdoğan Vatansever, Çağatay Ceylan, Bünyami̇n Akgül Jan 2022

Knockdown Of Death Receptor 5 Antisense Long Noncoding Rna And Cisplatin Treatment Modulate Similar Macromolecular And Metabolic Changes In Hela Cells, Di̇lek Cansu Gürer, İpek Erdoğan Vatansever, Çağatay Ceylan, Bünyami̇n Akgül

Turkish Journal of Biology

Background/aim: Despite great progress in complex gene regulatory mechanisms in the dynamic tumor microenvironment, the potential contribution of long noncoding RNAs (lncRNAs) to cancer cell metabolism is poorly understood. Death receptor 5 antisense (DR5-AS) is a cisplatin inducible lncRNA whose knockdown modulates cell morphology. However, its effect on cell metabolism is unknown. The aim of this study is to examine metabolic changes modulated by cisplatin and DR5-AS lncRNA in HeLa cells. Materials and methods: We used cisplatin as a universal cancer therapeutic drug to modulate metabolic changes in HeLa cervix cancer cells. We then examined the extent of metabolic changes …

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The Insider Trading Prohibition Theories In The Literature-A Critique, Mangesh Patwardhan Jan 2022

The Insider Trading Prohibition Theories In The Literature-A Critique, Mangesh Patwardhan

South Carolina Journal of International Law and Business

No abstract provided.

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The Moral Foundations Of Attitudes Toward Mask Wearing, Kristen N. Leighton Jan 2022

The Moral Foundations Of Attitudes Toward Mask Wearing, Kristen N. Leighton

Theses and Dissertations

As COVID-19 becomes endemic it is important to understand individual differences in motivation and adherence to mask wearing policies and recommendations. Mask wearing appears to be one way to protect communities, slow the spread, and save lives when COVID-19 rates spike in communities The main study aim was to examine how Moral Foundations Theory and Theory of Planned Behavior, specifically subjective norms, may explain individual differences in mask wearing to slow the spread of COVID-19. Understanding the psychological correlates of why and how often individuals wear a mask to slow the spread of COVID-19 can help community leaders, public health …

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