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The Effects Of Multimedia-Enhanced Instruction On Knowledge Gain And Retention Of Esl Learners: An Assessment Of Mayer’S Redundancy Principle, Araya Ramsin

PASAA

This quasi-experimental quantitative study investigated the effects of different formats of multimediaenhanced instruction on knowledge gain and retention of second language learners. The study focused specifically on assessing Mayer’s redundancy principle. Second language learners were randomly assigned into two groups and were presented with two formats of a multimedia-enhanced lesson: (1) images with audio and (2) images with audio and on-screen text. A repeatedmeasures analysis of covariance (ANCOVA) was carried out to evaluate change between pretest and immediate posttest, mean differences in knowledge gain between the two groups, group differences in growth from pretest to immediate posttest, change between immediate …

What’S The Beef? The Fda, Usda, And Cell-Cultured Meat, Tammi S. Etheridge

Washington and Lee Law Review

Over the past ten years, administrative law scholarship has increasingly focused on interactions between multiple agencies. As part of this trend, most scholars have called for policymakers to combine multiple agencies, rather than rely on a single agency, to solve policy problems. The literature in this area espouses the benefits of shared regulatory space. But very little of this scholarship addresses when shared jurisdiction is problematic. This is particularly concerning when an agency opts into or cedes oversight authority to another agency at will, with little regard for whether the second agency is an appropriate regulator. The case of cell-cultured …

The Trial Of Cinque - Steven Spielberg's Amistad, Jonathan Van Patten

Faculty Publications

No abstract provided.

P-Selectin And Complement’S Role In A Neonatal Model Of Germinal Matrix Hemorrhage-Induced Secondary Injury, Devin Scott Hatchell

MUSC Theses and Dissertations

Germinal Matrix Hemorrhage (GMH) is a devastating neurologic pathology in neonates that leads to impaired neurodevelopmental processes and approximately 90% rate of morbidity and mortality within two years in severe cases. Recent studies in our lab have indicated a role for complement in the initiation and propagation of secondary injury after GMH, which includes neuroinflammation and hydrocephalus development. Here we investigate a strategy to target complement inhibition specifically to sites of P-selectin expression, a relevant adhesion molecule at sites of vascular injury/inflammation, as well as investigate the role of P-selectin in leukocyte recruitment and the propagation GMH secondary injury. We …

The Impact Of Protein Tyrosine Phosphatase 1b On Impaired Insulin Signaling And Cognitive Impairment, Alexus S. Williams

MUSC Theses and Dissertations

High-fat diet (HFD) in mice, a mouse model of diet-induced obesity, display cognitive deficits, which correlate with hyperinsulinemia and reduced levels of brain insulin. The binding of insulin to the insulin receptor leads to tyrosine auto-phosphorylation of the receptor, which is a necessary step for the initiation of insulin transport. Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates tyrosine residues on the Insulin receptor. We hypothesize that diet-induced increases in PTP1B levels inhibits insulin receptor signaling contributing to cognitive impairment. To accomplish this, PTP1B levels, tyrosine phosphorylation, and cognition was assessed in mice placed on either a standard diet (STD) or HFD …

Role Of Perirhinal To Prefrontal Cortex Reciprocal Connection In Methamphetamine-Induced Memory Deficits, Jordan Hopkins

MUSC Theses and Dissertations

Chronic use of methamphetamine (meth) disrupts cortical processing across multiple cognitive domains including impulsivity, decision making and memory. Our laboratory has consistently shown that extended access to contingent meth self-administration reliably produces memory deficits in novel object recognition (NOR) tasks designed to test the “what” component of episodic memory in a rodent model. This type of memory is dependent on an intact function of the perirhinal cortex (PRH). However, the ongoing role of the prefrontal cortex (PFC) in this task and the directionality of communication between the PRH and the PFC is not entirely understood. A set of four experiments …

The Rural Settlements Of Hellenistic And Post-Hellenistic Central Asia: An Archaeology Of Indigenous Life Under Colonial Rule, Zachary W. Silvia

Bryn Mawr College Dissertations and Theses

Hellenistic Central Asia is among the most exoticized areas of study for Classical and Near Eastern archaeological research due to the discovery of ancient Greek colonies in the modern nations of Afghanistan, Tajikistan, and Uzbekistan. Most notable is the excavations of the Hellenistic “new foundation” at Ai Khanoum in the Dasht-i Qala Plain of northeast Afghanistan. This dissertation approaches Greek rule in Central Asia from a post-colonial perspective in decentering scholarly emphases on Hellenism in the east in favor of a new paradigm that emphasizes the diversity of indigenous lifeways among ancient, colonized Bactrians and Sogdians. Drawing on a vast …

Supporting Stylized Language Models Using Multi-Modality Features, Chengxi Li

Theses and Dissertations--Computer Science

As AI and machine learning systems become more common in our everyday lives, there is an increased desire to construct systems that are able to seamlessly interact and communicate with humans. This typically means creating systems that are able to communicate with humans via natural language. Given the variance of natural language, this can be a very challenging task. In this thesis, I explored the topic of humanlike language generation in the context of stylized language generation. Stylized language generation involves producing some text that exhibits a specific, desired style. In this dissertation, I specifically explored the use of multi-modality …

Further Investigation Of The Initiating Mechanism Of The Type I Collagen Glomerulopathy, Matthew James Freese

Graduate Theses/Dissertations

The progressive accumulation of collagen and other extracellular matrix proteins in the renal mesangium results in fibrosis, glomerulosclerosis, and eventual renal failure. Mice deficient in integrating α2(I) collagen into the type I collagen structure, termed Col1a2-deficient mice, model kidney fibrosis through the condition Type I Collagen Glomerulopathy, because homotrimeric type I collagen accumulates extracellularly in the mesangium of renal glomeruli. Accumulation of homotrimeric type I collagen compresses blood vessels in glomeruli, which reduces filtration, increases pressure, and results in fibrosis. Picrosirius red (PSR) staining was used on Col1a2 deficient and wildtype mice to evaluate collagen deposition. Histological evaluation and …

Modulation Of Ptz-Induced Convulsions In Rats Using Topiramate Alone Or Combined With Low Dose Gamma Irradiation: Involving Akt/M-Tor Pathway, Marwa Safar

Pharmacy

The current study evaluates the anticonvulsant effect low dose whole body gamma irradiation (LDR) alone or combined with topiramate against pentylenetetrazole (PTZ)-induced convulsions. Male Wister rats received either saline or PTZ (75mg/kg i.p.). The other three groups were pretreated with single low dose radiation (0.5Gy), topiramate (50mg/kg, p.o., seven days) and TPM with LDR respectively before PTZ injection. Racine’ score, latency, and duration of the convulsions were assessed. Glutamate and GABA were measured. AKT/m-TOR signaling pathway including AKT (protein kinase B), mammalian target of rapamycin (m-TOR), protein S6, and caspase 3 were also assessed. Measurements of markers of oxidative stress …

Sources And Therapeutic Strategies Of Mesenchymal Stem Cells In Regenerative Medicine, Mohamed M. Kamal, Dina H. Kassem

Pharmacy

During the past decade, mesenchymal stem cells (MSCs) have made their mark as a potential weapon in regenerative medicine. Since their first isolation by Friedenstein in the late 1970s of the last century, MSCs have opened new avenues in the field of regenerative medicine. The main fascination about MSCs lies in their ease of isolation and large ex vivo expansion capacity, as well as demonstrated multipotency and immunomodulatory activities. Basically, several reports have proved that MSCs isolated from different sources possess different characteristics and potentials. In addition, the mechanisms by which these cells can help regenerate tissues and treat several …

Cilostazol Alleviates Nlrp3 Infammasome–Induced Allodynia/Hyperalgesia In Murine Cerebral Cortex Following Transient Ischemia: Focus On Trpa1/Glutamate And Akt/Dopamine/Bdnf/Nrf2 Trajectories, Omnia S. Zaki, Noha N. Nassar, Dalaal M. Abdallah, Marwa Safar, Reham A. Mohammed

Pharmacy

Global cerebral ischemia/reperfusion (I/R) provokes infammation that augments neuropathic pain. Cilostazol (CLZ) has pleiotropic efects including neuroprotection in several ravaging central disorders; nonetheless, its potential role in transient central ischemic-induced allodynia and hyperalgesia has not been asserted before. Rats were allocated into 4 groups; sham, sham+CLZ, and 45 min-bilateral carotid occlusion followed by a 48 h-reperfusion period either with or without CLZ (50 mg/ kg; p.o) post-treatment. CLZ prolonged latency of hindlimb withdrawal following von Frey flaments, 4 °C cold, and noxious mechanical stimulations. Histopathological alterations and the immunoexpression of glial fbrillary acidic protein induced by I/R were reduced by …

A Novel Cyanopyridine Derived Fluorescent Sensor For Selective Determination Of Uranyl Ions In Different Water Samples, Ekram Hany Mohamed, Amany R Salem, Abeer M. El-Naggar,, Mohammed A. Amin,, Mohamed S. S. Attia

Pharmacy

A newly developed spectrofluorometric method is based on the fabrication of an optical cyanopyridine derived sensor, 4-(6-diaryl)-2-oxo -1,2-dihydropyridine-3-carbonitrile using microwave irradiation. The fluorescence intensity of the proposed chemo sensor was obviously quenched in DMSO owing to the presence of UO22+ ions at λex/λem = 320/360 nm. The quenching effect of the cyano-derivative based sensor was found to be proportional to the concentration of UO22+ ion ranging between 9.60 × 10–9–5.28 × 10–5 mol L−1 with a detection and quantification limits of 1.71 × 10–11 and 5.2 × 10–11 mol L−1, respectively. © 2021, Akadémiai Kiadó, Budapest, Hungary.

Treating For Two: Reforming Maternal Substance Abuse Policy, Katherine Drabiak

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Assessing The Potential Of The Unexploited Atlantic Purple Sea Urchin, Arbacia Punctulata, For The Edible Market, Coleen Suckling, Max D. Zavell, Anna L. Byczynski, Brian T. Takeda

Fisheries, Animal and Veterinary Sciences Faculty Publications

The global demand for sea urchin as seafood is currently unmet. Despite exploitation of > 40 species across the world, there is a need to identify other candidate species, especially in regions where diversification in production is sought where species are considered native. The Eastern US presents an opportunity to determine the marketability of the currently unexploited Arbacia punctulata which is naturally distributed from Massachusetts and southwards into the Gulf of Mexico. To determine whether A. punctulata had market potential, it was fed one of the following diets to determine whether the gonad tissue (uni) could be manipulated to increase gonad …

Evaluating Beluga (Delphinapterus Leucas) Blow Samples As A Potential Diagnostic For Immune Function Gene Expression Within The Respiratory System, Justin Thomas Richard, Krystle Schultz, Caroline E.C. Goertz, Roderick C. Hobbs, Tracy A. Romano, Becky L. Sartini

Fisheries, Animal and Veterinary Sciences Faculty Publications

Evaluating respiratory health is important in the management of cetaceans, which are vulnerable to respiratory diseases. Quantifying the expression of genes related to immune function within the respiratory tract could be a valuable tool for directly assessing respiratory health. Blow (exhale) samples allow DNA analysis, and we hypothesized that RNA could also be isolated from blow samples for gene expression studies of immune function. We evaluated the potential to extract RNA from beluga blow samples and tested whether transcripts associated with immune function could be detected with endpoint polymerase chain reaction. A total of 54 blow samples were collected from …

Why Not Both Nature And Nurture: Using Behavioral Genetic Markers As Sentencing Factors, Seely Kaufmann

Law Student Publications

"On the evening of July 1, 2013, Amos Wells was upset that his pregnant girlfriend, Chanice Reed, would not answer his calls. He then drove to where she, her mother Annette, and ten-year-old brother Eddie, lived. After arguing with Chanice and yelling at the top of his voice in a “bone-chilling scream,” Wells retrieved a handgun from his Chevrolet Tahoe parked in front of the house, and shot Chanice in the front yard as she screamed, “No, no, no.” Her mother then tried to bat the gun away before he shot her too. Further shots were heard before Wells finally …

Biology News 2022, University Of Northern Iowa. Department Of Biology.

Biology News

Contents:

Letter from the Department Head ---- 2
Preparing Science Teachers ---- 2
Learning Biology at UNI ---- 3
In Case You Missed it ---- 4
Ch-ch-ch Changes ---- 4
Support the Programs that Mean the Most to You ---- 5
Connect with Us ---- 5

Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton

All ETDs from UAB

People living with HIV (PLWH) have experienced substantial increases in life expectancy, largely attributable to improvements in care such as antiretroviral therapy. As a result, there has been a concurrent increase in the development of aging-related comorbidities such as end-stage organ disease. One such comorbidity is kidney disease. Concerningly, PLWH are at disproportionately higher risk of chronic kidney disease and end-stage kidney disease (ESKD) as compared to HIV-negative counterparts. Kidney transplantation is the ideal therapy for ESKD as it is both cost-effective and provides a significant survival benefit and yet, despite excellent transplant outcomes among PLWH, access to transplantation among …

Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

Friedreich’s ataxia (FRDA) is the most common inherited ataxia worldwide. This autosomal recessive neurodegenerative disorder manifests in the central and peripheral nervous system but also affects the cardiovascular and endocrine systems. No effective treatment is available. FRDA is caused by expansion of GAA repeat tracts in intron 1 of the frataxin (FXN) gene on both alleles. An inverse correlation between FXN levels and GAA repeat length exists. Frataxin is a mitochondrial protein participating in iron-sulfur (Fe-S) cluster formation. Frataxin deficiency results in reduced activity of Fe-S-containing enzymes involved in critical biological processes, such as cellular respiration and DNA repair. Expansion …

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

Hail, Caesar!, Kel R. Karpinski

Publications and Research

This piece looks at queer characters in the Coen Brothers’ film Hail, Caesar! (2016). The film takes place during the heyday of the Hollywood film studio set in 1951 and draws on many films during that time period of the 1930s, 40s and 50s.

A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

istorically, research has often been conducted in a hypothesis-driven manner with software development methodologies created to support those efforts. However, in recent years data-driven approaches to research have seen a dramatic rise in prominence. While software development methodologies such as agile development, extreme programming, and the waterfall model have allowed developers to tackle increasingly complex problems, they were not designed to efficiently support data-driven approaches such as the machine learning paradigm. To address the need to support the different programmatic requirements of both classical, hypothesis-driven as well as data-driven development, novel development strategies are warranted. In this research, we adapted …

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si

All ETDs from UAB

Malignant cancer is one of the greatest threats to human health globally. Conventional (non-targeted) treatments such as chemo-drugs and radiation therapy remain the major choices for cancer patients while always accompanied by severe systemic toxicity/side effects. Monoclonal antibody (mAb) is one of the most successful biomolecules discovered and well investigated as a targeted therapy to treat human disease. This dissertation research was aimed to develop monoclonal antibody-based targeted drugs for cancer treatment, which include antibody-drug conjugates (ADCs), liposomal drug and exosome-based drug delivery. Novel targets were discovered, screened and confirmed by proteomics, western blotting and flow cytometry analysis. Cancer cells …

Cultural Organizations, Kean University

Evidence Inventory

No abstract provided.

Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Objective: Unintentional childhood injuries present a substantial public health burden in low- and middle-income countries (LMIC) including Uganda. Interventions to reduce this risk should be responsive to children’s unique developmental, environmental, and sociocultural context. This project had three primary objectives: 1) Analyzing caregiver reports of child injury events in rural Uganda to identify perceived causal and preventative factors; 2) Identifying Ugandan first and sixth graders’ developmental safety needs by comparing hazard recognition and past-year injuries among these students; and 3) Evaluating the impact of the Careful Cubs intervention on Ugandan first graders’ personal safety knowledge, skills, and beliefs. Methods: 1) …

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser

All ETDs from UAB

Organisms produce chemical defenses to gain a competitive advantage, and to protect themselves from pathogens and predators. There is high inter- and, sometimes, intraspecific diversity in the types and quantities of defensive secondary metabolites. Yet, we do not know much about the mechanisms driving the diversity and its distribution. Macroalgae are important members of ecosystems since they provide living space and are primary producers. To prevent predation, macroalgae make structural or chemical defenses. Chemical defenses in the Antarctic red macroalga Plocamium sp. have extensively been studied. It is widespread along the western Antarctic Peninsula and abundant at sites where it …

The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller

All ETDs from UAB

Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor grows a vascular supply is needed to deliver oxygen and nutrients into the increasing mass. Several anti-angiogenic cancer therapies target VEGF and its receptor VEGFR-2, which are major promoters of blood vessel development. Unfortunately, many of these cancer treatments fail to completely stop angiogenesis in the tumor microenvironment (TME). Since these therapies focus on the biochemical activation of VEGFR-2 via VEGF ligand binding, we …