Digital Commons Network^™

Implementation Of Structure From Motion (Sfm) Technology For Edcuational Lessons, Valeria Veronica Martinez

Open Access Theses & Dissertations

Education is the most important obligation the humanity race has in order to evolve and thrive in the modern world. There are various applications for educators to teach valuable lessons to students, and not all deliveries will be the same for every lesson and for every student. Lesson being taught, the lesson delivery from educator to student often changes every time the lesson is implemented, depending on the learning ability of the students. Students have the ability to learn in different ways, such as the visual, auditory, kinesthetic, reading and writing learners (Oxford 2003). As educators aware of the four …

Modulation Of Non-Diffracting Hermite Gaussian Beams And Nonlinear Optical Microscopy For Nanoscale Sulfur Imaging, Gilberto Navarro

Open Access Theses & Dissertations

Hermite Gaussian beams are the solutions of the scalar paraxial wave equation in Cartesian coordinates. A method was developed to modulate the intensity profile of non-diffracting Hermite Gaussian (HG) beams. The original HG beamâ??s intensity profile consists of high intense corner lobes and low intense central lobes which is not ideal for structured illumination in light-field microscopy. The modulated HG beams were generated by multiplying the original HGâ??s beam envelope by a super-Gaussian envelope to modify the intensity profile to attain equal intensity lobes. The propagation of the original HG beam and modulated HG beam were compared to determine that …

Predictive Utility Of The El Paso Pretrial Risk Assessment Instrument - Revised (Eppra-R), Chelsea Sierra Queen

Open Access Theses & Dissertations

Pretrial risk assessments are used to divert defendants from pretrial detention by estimating risk of pretrial specific outcomes (i.e., failure to appear, rearrest). Ongoing validation of this tool is recommended to assess accuracy and ensure that there is no bias against specific subgroups (e.g., gender, race/ethnicity, or age) of defendants. The present study evaluates the utility of a locally developed instrument in El Paso County - a predominantly Latinx county. Area Under the Curve (AUC) Receiving Operator Condition (ROC) analyses indicate statistically â??fairâ?? predictive utility for the tool. Binary logistic regression models suggest no evidence of bias. This study will …

Analyzing The Supply Chain Operation Of A Fast-Food Restaurant Using Simulation Modeling And Developing A Cost Estimation Optimization Model In The Disruption Period, Amit Kumar Saha

Open Access Theses & Dissertations

Supply chain operation performance is a much-discussed topic over the last decade which will lead to optimizing the resources required to provide the necessary level of customer service to a specific segment and improve customer service through increased product availability and reduced order cycle time. During disruption in supply chain, performance parameter changes, and the overall supply chain cost at each stage increases. External factors such as labor shortages, delayed and costly supplies, and decreased demand also contribute to this cost. This thesis work presents a research-focused analysis of a small pizza shop, under circumstances that include the loss of …

Hybrid Model For Making Decision Methods In Wireless Sensor Networks Through Neuro-Fuzzy Inference System, Martha Lucia Torres

Open Access Theses & Dissertations

Considering the complexity and multiple alternatives for technology decisions in Wireless Sensor Networks (WSNs), a multicriteria selection method (MCDM) is an appropriate approach for choosing the best option in technical projects. Purely quantitative decision-making procedures have currently been created based on client requirements and recommendations from industry professionals in many domains. In this context, implementation and operational costs could be increasing due to technical problems and additional processes. In order to prevent future difficulties and obtain a more accurate technology selection, a new method was being developed to involve qualitative and quantitative parameters taken from real scenarios and technical literature …

Survey Of Fleas And Ticks For Rickettsia Rickettsii And Rickettsia Typhi And Surveys Of Humans And Wild Animals For Serological Evidence Of Infection By These Rickettsiae In Rural And Urban Areas Of El Paso, Texas And Other Areas Of Texas, Karen Rocio Valdez

Open Access Theses & Dissertations

The ecology and epidemiology of Rocky Mountain Spotted fever and typhus fever pathogens are poorly understood along the United Statesâ??Mexico border, especially in the far Southwestern region of Texas. The objective of this dissertation was to understand the prevalence and distribution of Rickettsia rickettsii and Rickettsia typhi and associated tick and flea species and the prevalence of these Rickettsiae in domestic and feral mammals in urban and rural areas of the El Paso community and other areas of Texas. Also, the goal was to determine if humans are being infected by R. rickettsii and R. typhi in the El Paso …

Human Loss-Of-Function Variants In The Serotonin 2c Receptor Associated With Obesity And Maladaptive Behavior, Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes De Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi

Children’s Nutrition Research Center Staff Publications

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT2CR (HTR2C) in 19 unrelated people (3 males and 16 females). Eleven variants caused a loss of function in HEK293 cells. All people who carried variants had hyperphagia and some degree of maladaptive behavior. Knock-in male mice harboring a human loss-of-function HTR2C variant developed …

Single-Cell Crispr Immune Screens Reveal Immunological Roles Of Tumor Intrinsic Factors, Jiakai Hou, Shaoheng Liang, Chunyu Xu, Yanjun Wei, Yunfei Wang, Yukun Tan, Nidhi Sahni, Daniel J Mcgrail, Chantale Bernatchez, Michael Davies, Yumei Li, Rui Chen, S Stephen Yi, Yiwen Chen, Cassian Yee, Ken Chen, Weiyi Peng

Faculty, Staff and Student Publications

Genetic screens are widely exploited to develop novel therapeutic approaches for cancer treatment. With recent advances in single-cell technology, single-cell CRISPR screen (scCRISPR) platforms provide opportunities for target validation and mechanistic studies in a high-throughput manner. Here, we aim to establish scCRISPR platforms which are suitable for immune-related screens involving multiple cell types. We integrated two scCRISPR platforms, namely Perturb-seq and CROP-seq, with both in vitro and in vivo immune screens. By leveraging previously generated resources, we optimized experimental conditions and data analysis pipelines to achieve better consistency between results from high-throughput and individual validations. Furthermore, we evaluated the performance …

Development Of Myelinating Glia: An Overview, Carlo D Cristobal, Hyun Kyoung Lee

Duncan NRI Faculty and Staff Publications

Myelin is essential to nervous system function, playing roles in saltatory conduction and trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central and peripheral nervous systems respectively and follow different developmental paths. OLs are neural stem-cell derived and follow an intrinsic developmental program resulting in a largely irreversible differentiation state. During embryonic development, OL precursor cells (OPCs) are produced in distinct waves originating from different locations in the central nervous system, with a subset developing into myelinating OLs. OPCs remain evenly distributed throughout life, providing a population of responsive, multifunctional cells with the capacity to remyelinate …

Phase I Car-T Clinical Trials Review, Shaun Bulsara, Mengfen Wu, Tao Wang

Center for Medical Ethics and Health Policy Staff Publications

Background/aim: Chimeric antigen receptor (CAR) T cells with tumor specificity are being increasingly investigated. Phase I trials are the first step of testing for safety of novel CAR-T therapy to determine the maximum tolerated dose (MTD). Several dose escalation methods have been developed over time including rule-based, model-based, and model-assisted designs. The goal of this project is to overview the phase I designs used in current CAR-T trials.

Materials and methods: We searched PubMed for peer-reviewed literature published between January 1, 2015 and December 31, 2021. The search was limited to human studies in the English language using the keywords …

Correction Of Velopharyngeal Insufficiency Secondary To Palatal Gunshot Wound: Case Presentation And Review Of The Literature, Rogelio Martinez-Wagner, Cristopher Cardenas-Cruz, Ivan Ortiz-Monasterio, Edgar Vargas, Maria M. Cabrera, Pablo A. Ysunza, M. Del Carmen Pamplona, Diane E. Campos-Lopez

Articles

Reconstruction of midfacial traumatic defects secondary to a gunshot wound (GSW) is one of the most challenging head surgeries. The high impact on the functional and aesthetic quality of life, and the small margin of error to achieve a successful outcome are significant hurdles in the surgical treatment of these cases. Here we report a 33-years old patient who suffered a GSW with an entrance wound penetrating between the soft and hard palate and an exit wound on the right malar region. A description of the case and a systematic review of the literature were conducted. The treatment depends on …

Early Systemic Glycolytic Shift After Aneurysmal Subarachnoid Hemorrhage Is Associated With Functional Outcomes, Aaron M Gusdon, Chenlian Fu, Vasanta Putluri, Atzhiry S Paz, Hua Chen, Xuefang Ren, Mohammed Khurshidul Hassan, Pramod Dash, Cristian Coarfa, Nagireddy Putluri, Huimahn A Choi, Jude P J Savarraj

Faculty, Staff and Student Publications

BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) leads to a robust systemic inflammatory response. We hypothesized that an early systemic glycolytic shift occurs after aSAH, resulting in a unique metabolic signature and affecting systemic inflammation.

METHODS: Control patients and patients with aSAH were analyzed. Samples from patients with aSAH were collected within 24 h of aneurysmal rupture. Mass spectrometry-based metabolomics was performed to assess relative abundance of 16 metabolites involved in the tricarboxylic acid cycle, glycolysis, and pentose phosphate pathway. Principal component analysis was used to segregate control patients from patients with aSAH. Dendrograms were developed to depict correlations between metabolites and …

Characterizing Treatment Resistance In Muscle Invasive Bladder Cancer Using The Chicken Egg Chorioallantoic Membrane Patient-Derived Xenograft Model, Hugo Villanueva, Gabrielle A Wells, Malachi T Miller, Mariana Villanueva, Ravi Pathak, Patricia Castro, Michael M Ittmann, Andrew G Sikora, Seth P Lerner

Faculty, Staff and Student Publications

BACKGROUND: Non-metastatic muscle invasive urothelial bladder cancer (MIBC) has a poor prognosis and standard of care (SOC) includes neoadjuvant cisplatin-based chemotherapy (NAC) combined with cystectomy. Patients receiving NAC have at best

METHODS: We optimized engraftment conditions for primary MIBC tumors using the CAM-PDX model and tested concordance between cisplatin-based chemotherapy response of patients to matching PDX tumors using tumor growth coupled with immunohistochemistry markers of proliferation and apoptosis. We also tested select kinase inhibitor response on chemotherapy-resistant bladder cancers on the CAM-PDX using tumor growth measurements and immuno-detection of proliferation marker, Ki-67.

RESULTS: Our results show primary, NAC-resistant, MIBC tumors …

Metal Transfer To Sediments, Invertebrates And Fish Following Waterborne Exposure To Silver Nitrate Or Silver Sulfide Nanoparticles In An Indoor Stream Mesocosm, Nathaniel Clark, Joanne Vassallo, Pv Silva, Arr Silva, Marta Baccaro, Neja Medvešček, Magdalena Grgić, Abel Ferreira, Martí Busquets-Fité, Kerstin Jurkschat, Anastasios G. Papadiamantis, Victor Puntes, Iseult Lynch, Claus Svendsen, Den Brink Nw Van, Gestel Cam Van, Susana Loureiro, Richard D. Handy

School of Health Professions

No abstract provided.

Human Appropriation Of Net Primary Production Through Crops, Grazing, And Forestry In The U.S. From 1997 To 2012, Suman Paudel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation conducts a county-level analysis of human appropriation of net primary production (HANPP) harvested from crops, timber and grazing in the conterminous United States in the years 1997, 2002, 2007 and 2012. This study consists of three manuscripts (Chapters 2, 3, and 4). The first study quantifies net primary production in US counties in 1997, 2002, 2007 and 2012. The detailed HANPP study conducted concludes that HANPP is a valuable footprint tool for analyzing land use intensity and agricultural ecosystems. The second manuscript shows how HANPP is an improved or modernized ecological footprint and is a sustainable indicator as …

Rainfall Increases Alpha And Has No Effect On The Beta Diversity Of Animal-Dispersed Shrubs In Panama, Rosemary Hopson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Climate patterns affect where plants can grow and survive. In tropical areas, the main form of precipitation is rain, and rainfall has been demonstrated to influence tree species distributions. For this thesis, I examined the relationship between rainfall and the diversity of animal-dispersed tropical shrubs. To do this, I used data on shrub diversity collected in the summer of 2017. Plots were established across the Isthmus of Panama, from the drier Pacific side to the wetter Atlantic side, to survey animal-dispersed shrubs. I analyzed three metrics of diversity that weigh rare and common species differently. The first weighs rare species …

Bugs, Bullets And Birds: Factors Affecting The Health And Survival Of Ferruginous Hawk Nestlings In The Intermountain West, Ellis A. Juhlin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Ferruginous Hawks are a bird of prey species that nest in sagebrush steppe and grassland habitat. These birds are threatened by habitat loss and fragmentation from urbanization, rural development, oil and natural gas extraction, habitat treatment projects, and wildfires, and experiencing widespread population declines across their breeding range. Because of this, Ferruginous Hawks (FEHAs) have been deemed a Species of Greatest Conservation Need by state management agencies in Utah, Idaho, Wyoming and Nevada. The health and survival of Ferruginous Hawk (FEHA) nestlings is crucial to long-term population viability. Understanding the threats these birds are facing as nestlings can provide valuable …

Storytelling To Promote Mental Health: A Conceptual Analysis And Application With Acceptance And Commitment Therapy For Depression, Carter H. Davis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Mental health treatments can be delivered in many ways. One approach is to use storytelling to communicate healthy practices. While societies across the world have engaged in storytelling for thousands of years, these practices have been used less in the mental health field. The aim of this project was to study the overlap between the areas of mental health and storytelling. We also tested how a storytelling-based mental health treatment could help solve a particular clinical problem. In this case, the problem of people who receive inadequate help for managing depression through medication alone.

We examined one particular mental health …

Together, Our Voices Will Strengthen The Weaving: Using Autoethnography And Narrative Inquiry To Indigenize Sense Of Belonging In Higher Education, Devon S. Isaacs

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Native American students in higher education are often asked to find a sense of belonging in places and spaces that do not reflect their cultures or worldviews. This can lead to isolation and a feeling of having to choose between themselves and their identities as Indigenous peoples. This contributes to poorer mental health, loss of well-being, and decreased academic success. The purpose of this study was to ask seven Native American participants how they defined sense of belonging from their own worldviews. Participants were also asked about spaces and places in higher education that helped or did not help them …

Quantifying Floral Resource Availability Using Unmanned Aerial Systems And Machine Learning Classifications To Predict Bee Community Structure, Jesse Anjin Tabor

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Bees are important for agricultural and non-agricultural ecosystems because they pollinate both wild plants and commercial crops. Flowers provide pollen and nectar resources that bees use to survive and reproduce. Measuring the relationship between the floral community and bee community may help apiarists and land managers to make informed decisions in managing wild and domesticated bee species. Manual methods to describe and count flowering vegetation is costly in time and personnel. Unmanned aerial vehicle (UAV) technology may be an efficient way to describe and count flowering vegetation on a large scale. UAVs with classification analysis and ground transect surveys were …

Event-Based Obstacle Detection With Commercial Lidar, Chaz Cornwall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Computerized obstacle detection for moving vehicles is becoming more important as vehicle manufacturers make their systems more autonomous and safe. However, obstacle detection must operate quickly in dynamic environments such as driving at highway speeds. A unique obstacle detection system using 3D changes in the environment is proposed. Furthermore, these 3D changes are shown to contain sufficient information for avoiding obstacles. To make the system easy to integrate onto a vehicle, additional processing is implemented to remove unnecessary dependencies. This system provides a method for obstacle detection that breaks away from typical systems to be more efficient.

The Relationship Between Bird Species Richness And Human Appropriation Of Net Primary Productivity, Kaeli Mueller

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

As humans harvest increasing amounts of biomass, it is crucial to gain an understanding of how much energy is being appropriated and the impact that this could have on ecosystems and biodiversity. The primary way in which humans impact biodiversity loss is through land use change. One way of quantifying the impact of land use change is through human appropriation of net primary production (HANPP). This measurement represents the total amount of energy derived from photosynthesis that humans remove from ecosystems and appropriate for their own use. My research studies the relationship between HANPP and bird species richness at the …

Design Of Environment Aware Planning Heuristics For Complex Navigation Objectives, Carter D. Bailey

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A heuristic is the simplified approximations that helps guide a planner in deducing the best way to move forward. Heuristics are valued in many modern AI algorithms and decision-making architectures due to their ability to drastically reduce computation time. Particularly in robotics, path planning heuristics are widely leveraged to aid in navigation and exploration. As the robotic platform explores and navigates, information about the world can and should be used to augment and update the heuristic to guide solutions. Complex heuristics that can account for environmental factors, robot capabilities, and desired actions provide optimal results with little wasted exploration, but …

Bedrock Geology Map Of The Naomi Peak 7.5' Quadangle, Cache County, Utah And Novel Age Constraints On Its Cambrian Strata, Hannah R. Cothren

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Geologists use various “rock-clocks” in order to interpret the timing and tempo of events in Earth’s history. These include global geochemical events in the oceans (chemostratigraphy), the evolution of certain fossil species (trilobite biostratigraphy), and the radiogenic decay of uranium to lead in certain mineral such as zircon (U-Pb geochronology). Integrating these methods in the stratigraphic record in one location can provide a well-constrained timeline for a select part of the Geologic, or Deep Time, record. This technique is especially important in the Cambrian Period (538.8 to 486.9 million years; Ma), which sets the stage for life today with the …

Nest‐Site Selection, Success, And Response To Predators By Cinnamon Teal And Other Ground‐Nesting Ducks In The Wetlands Of Great Salt Lake, Utah, Mark E. Bell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The wetlands of Great Salt Lake once supported hundreds of thousands of nesting ducks each year. In recent years, the number of nesting ducks in the same area was a fraction of those historic numbers. While many species of ducks do not rely on these wetlands for primary nesting habitat, cinnamon teal (Spatula cyanoptera) do. Great Salt Lake and its associated wetlands are in the heart of the cinnamon teal breeding range, and once supported half of the continental population.

These wetlands are unique from other wetlands where waterfowl nest because they are artificially created using dams to hold …

Preference Reversals In Delay Of Gratification, Jeremy M. Haynes

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Intertemporal choices are decisions between outcomes occurring at different times. For example, people may choose to quit smoking cigarettes for the delayed health-related benefits associated with abstention, or they may continue to smoke for the immediate gratification associated with smoking now. Importantly, patterns of intertemporal choices among people are associated with a number of maladaptive behaviors (e.g., cigarette smoking). In the present set of studies, I examine a facet of intertemporal choice: preference reversals. Although there are multiple forms of preference reversal, I focus on those characterized by shifts in preference from a larger-later reward to a smaller-immediate reward after …

Functional Characterization Of The Newly Discovered Type V Crispr-Cas Protein Cas12a2, Dylan J. Keiser

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Similarly to people, bacteria are under the treat of infection by viruses. To circumvent these threats, bacteria evolve complex immune systems. Our understanding of some of these immune systems has led to many advancements in the field of Biotechnology including tools that made expressing proteins for study in a lab easier, tools that revolutionized the feasibility of gene editing, and tools that could change the way we think about viral diagnostics and cancer therapeutics. A certain type of immune system that bacteria use to fight virus is called a CRISPR system. Presented here is work to understand the function of …

Insecticide Susceptibility And Resistance Detection In Phlebotomus Argentipes Sandflies (Diptera: Psychodidae: Phlebotominae), Shawna M. Hennings

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Leishmaniasis is an understudied disease found predominantly in high heat and humidity areas. The disease is transmitted by sandflies which are blood-feeding, biting insects. There is currently no known vaccine for any form of leishmaniasis and treatment imposes a significant economic impact on already poor and marginalized populations, as well as severe, lingering side effects for afflicted individuals. Annually, there are millions of people around the world afflicted with a form of Leishmaniasis that is transmitted by species of sandflies. The primary sandfly population control method for over half a century has been indoor residual spraying using insecticides. The selective …

Immunological Tradeoffs And The Impacts Of Urbanization On The Reproductive Ecology And Physiology Of The Side-Blotched Lizard (Uta Stansburiana), Emily E. Virgin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Investing resources into reproduction can limit energy available to other competing demands, such as fighting off an infection; yet, both processes are necessary for organisms to survive and pass on their genes to the next generation. These strategies often follow patterns associated with lifespan, such that shorter-lived animals are more likely to invest more resources into reproduction over survival, and vice versa in long-lived animals. However, environmental change caused by urbanization can disrupt these relationships, and the within- and transgenerational costs of urbanization on females and offspring are unknown. I address these uncertainties in three research chapters to better understand …

The Latter-Day Saint Home As A Site Of Religious Transition, 1890–1930, Cathy Gilmore

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis examines religion as practiced in the Latter-day Saint home during a period of religious transition between 1890 and 1930. Using the family of June A. Bushman and Hyrum Smith as subjects, we examine how families managed the religious reforms of the Church of Jesus Christ of Latter-day Saints during this period. As individuals who came of age at the turn of the twentieth century, June and Hyrum’s lives intersected with their church’s transition from an isolated religion to a modern, American church.
Administrative modernization, priesthood reforms, reimagined family relationships, and other ecclesiastical changes came into tension with the …