Digital Commons Network^™

Exploring Prospective 1-8 Teachers' Number And Operation Sense In The Context Of Fractions, Marta T. Magiera, Leigh A. Van Den Kieboom

Mathematical and Statistical Science Faculty Research and Publications

This exploratory study examined prospective elementary teachers’ (PSTs’) number and operation sense (NOS) in the context of solving problems with fractions. Drawing on the existing literature, we identified seven skills that characterize fraction-related NOS. We analyzed 230 responses to 23 tasks completed by 10 PSTs for evidence of PSTs’ use of different fraction-related NOS skills. The analysis revealed that PSTs did not use all seven fraction-related NOS skills to the same extent. PSTs’ responses documented their frequent reasoning about the meaning of symbols and formal mathematical language in the context of fractions. To a lesser extent, PSTs’ responses documented their …

You Dropped The Bomb On Me – A Case Series Of Carbon Tetrachloride Toxicity, Derek J. Fikse Do, Amanda R. Stashin, Scott Wheatley Md, Kenneth D. Katz Md, Andrew L. Koons

Toxicology Division

No abstract provided.

Brorphine, Isotonitazene And Metonitazene Emerge As New Age Opioids, Alexandra Amaducci, Kim Aldy, Sharan Campleman, Alison Meyn, Stephanie Abston, Alex Krotulski, Barry Logan, Paul Wax, Jeffrey Brent, Alex Manini

Toxicology Division

No abstract provided.

Sniffing Skeletal Fluorosis: A Rare Manifestation Of Difluoroethane Inhalant Abuse, Derek J. Fikse Do, Andrew H F Miller Do, Danny Le, Ryan M Surmaitis Do

Toxicology Division

No abstract provided.

Lithium Toxicity: A Case Report Of Toxicity Resulting In A Third-Degree Heart Block, Samantha L. Gaetani Md, Alexandra Amaducci, Derek J. Fikse Do, Andrew L. Koons

Toxicology Division

No abstract provided.

Copyright And Parody: Touring The Certainties Of Intellectual Property And Restitution, Wendy J. Gordon

Faculty Scholarship

The essay that follows examines the boundary between two sets of rules. The first set arises under the law of Restitution, particularly the rule that volunteers ordinarily need not be rewarded. (Another way to state this same Restitution rule is to say that the retention of benefit voluntarily conferred is ordinarily not "unjust enrichment".) The second set of rules are those of Intellectual Property law, which creates property in a special kind of volunteer. My argument is simply that the law of Restitution leads almost directly to the law of Intellectual Property, though the two areas are premised on diametrically …

Ten Truths About Tax Havens: Inclusion And The "Liberia" Problem, Steven A. Dean, Attiya Waris

Faculty Scholarship

There has been a decades-long effort to repair an increasingly fragile international tax system. One reason it has foundered has been what we identify as the "Liberia problem." In 2000, the powerful Organization for Economic Cooperation and Development identified Liberia but not Switzerland as a tax haven and targeted it for sanctions. It did not go well. During the two decades since, everything has changed; yet seemingly from this lens of inclusion, nothing has changed at all. Awkwardly similar "blacklists" still target "Black" and "Brown" jurisdictions despite the fact that experts mean something quite different when they speak of the …

A Constitutional Moment In Cross-Border Taxation, Steven Dean

Faculty Scholarship

The complex pattern of formal and informal rules that governs the taxation of cross-border transactions tends to be thought of as rigidly path dependent. (Rixen, 2011) In truth, the Classification and Assignment Constitution has repeatedly undergone sudden changes initiated by influential actors. A failure to acknowledge the power wielded by a handful of states and organizations nurtures an evolutionary myth of cross-border taxation, but a close examination reveals traces of intelligent design, with repeated interventions altering the course of its development.

A century ago a material constitution coalesced around an elegant but flawed algorithm providing for the "classification and assignment …

Long Noncoding Rnas And Their Therapeutic Promise In Diabetic Nephropathy, Juan D Coellar, Jianyin Long, Farhad R Danesh

Faculty, Staff and Students Publications

Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes. Importantly, an association between aberrant expression of lncRNAs and diverse human pathologies has been reported, including in a variety of kidney diseases. These observations have raised the possibility that lncRNAs may represent unexploited potential therapeutic targets for kidney diseases. Several important questions regarding the functionality of lncRNAs and their impact in kidney diseases, however, remain to be carefully addressed. Here, we provide an overview of the main …

Alpha-Single Chains Of Collagen Type Vi Inhibit The Fibrogenic Effects Of Triple Helical Collagen Vi In Hepatic Stellate Cells, Christian Freise, Hyunho Lee, Christopher Chronowski, Doug Chan, Jessica Cziomer, Martin Rühl, Tarkan Dagdelen, Maik Lösekann, Ulrike Erben, Andre Catic, Werner Tegge, Detlef Schuppan, Rajan Somasundaram, Ergun Sahin

Faculty, Staff and Students Publications

The interaction of extracellular matrix (ECM) components with hepatic stellate cells (HSCs) is thought to perpetuate fibrosis by stimulating signaling pathways that drive HSC activation, survival and proliferation. Consequently, disrupting the interaction between ECM and HSCs is considered a therapeutical avenue although respective targets and underlying mechanisms remain to be established. Here we have interrogated the interaction between type VI collagen (CVI) and HSCs based on the observation that CVI is 10-fold upregulated during fibrosis, closely associates with HSCs in vivo and promotes cell proliferation and cell survival in cancer cell lines. We exposed primary rat HSCs and a rat …

A Code Of Ethics For Gene Drive Research, George J. Annas, Chase L. Beisel, Kendell Clement, Andrea Crisanti, Stacy Francis, Marco Galardini, Roberto Galizi, Julian Grunewald, Greta Immobile, Ahmad S. Khalil, Ruth Muller, Vikram Pattanayak, Karl Petri, Ligi Paul, Luca Pinello, Alekos Simoni, Chrysanthi Taxiarchi, J. Keith Joung

Faculty Scholarship

Gene drives hold promise for use in controlling insect vectors of diseases, agricultural pests, and for conservation of ecosystems against invasive species. At the same time, this technology comes with potential risks that include unknown downstream effects on entire ecosystems as well as the accidental or nefarious spread of organisms that carry the gene drive machinery. A code of ethics can be a useful tool for all parties involved in the development and regulation of gene drives and can be used to help ensure that a balanced analysis of risks, benefits, and values is taken into consideration in the interest …

Antibiotic Development Incentives That Reflect Societal Value Of Antibiotics, Helen Boucher, Thomas M. File, Vance Fowler, Amanda Jezek, John Rex, Kevin Outterson

Faculty Scholarship

TO THE EDITOR—Rome and Kesselheim [1] claimed that rewarding developers of novel antibiotics with transferable exclusivity vouchers is an expensive approach to promoting antibiotic development. This analysis is incomplete as it focuses only on the cost of bringing new antibiotics to market without acknowledging their societal value. The authors also did not suggest an alternative approach. With patients running out of treatment options for resistant infections, failing to strengthen the antibiotic pipeline is not a reasonable option.

Rethinking "Political" Considerations In Investment, David H. Webber

Faculty Scholarship

Five years ago, Professor David H. Webber was invited to deliver an address both to our Delaware Law School community and to the Delaware Bench and Bar as Visiting Scholar in Residence of Corporate and Business Law. Webber's Speech, "Rethinking 'Political' Considerations in Investment," made several predictions about the rise of politicized investment which were quite prescient. As relevant today as when it was delivered, this piece explores the consideration of investment factors outside the traditional realm of shareholder profit maximization, both in its current state and in the future. Webber's analysis of how investors balance the role of capital …

Visual Presentation Of Mirr And Mnpv Calculations, Tom Arnold, Joseph Farizo

Finance Faculty Publications

Project cash flows and modified cash flows are presented in an illustrative graphic within Excel for the live or virtual classroom. Further, the graphic computes and displays the relevant modified internal rate of return (MIRR) and modified net present value (MNPV), with associated formulas. The presentation allows for a discussion of the reinvestment assumption attributed to the internal rate of return (IRR) and the net present value (NPV) calculations.

New Faculty Research Profile: Martin A. Edwards: Bibliometric Analysis Of His Research, Lutishoor Salisbury, Yang Tian, Jeremy Smith

University Libraries Faculty Publications and Presentations

This poster was compiled to welcome Dr. Martin A. Edwards as an Assistant Professor in the Chemistry and Biochemistry Department at the University of Arkansas in 2020. It provides a bibliometric analysis of his research achievements and their scholarly impact.

Planning And Hosting A Virtual Science-Fiction Event Series, Holly M. Surbaugh, Glenn Koelling

University Libraries & Learning Sciences Faculty and Staff Publications

As the University of New Mexico responded to the coronavirus pandemic with emergency building closures and a shift to online services, the University Libraries faced challenges making and maintaining personal connections with users in the absence of face-to-face contact. Recognizing that necessary public health restrictions isolated all students, faculty, and staff to some extent, a science librarian and an English librarian collaborated to develop a series of three Zoom-facilitated programs that provided fun activities (i.e., a movie watch party, a book discussion, and a team trivia game) to engage a socially distanced campus community while highlighting various library resources. They …

Dual Panics: A Media Analysis Of Narratives On The Role Of Unauthorized Migration In America's Overdose Crisis, Morgan Godvin

University Honors Theses

Background: The realms of drug policy and immigration policy have long been fueled by misinformation, where sensationalism and panics help shore up political support. Most recently, the "border crisis" has been invoked to explain the "overdose crisis" in mass media narratives. Although the increase in migration is being blamed for illicit drug flows, drug importation occurs primarily through legal points-of-entry. The extent and excess visibility of false narratives linking overdose to migration in mainstream media is unknown.

Methods: We used the Media Cloud ecosystem to compile and characterize mainstream media content published between June 2021 and July 2021 regarding the …

Genome-Wide Sequencing In Clinical Genetic Counseling, Sydney Schulz

University Honors Theses

Genome-wide Sequencing provides an exciting opportunity for the future of genetic counseling. However, the efficacy of GWS in covering G-C rich regions of DNA, detection of variants, coverage of the exome, reanalysis, and identifying disease origin in non-coding regions of DNA remains to be proven. GWS provides a diagnostic success rate of 36-73% in pediatric cases and 50-67% of adult rare disease and alters the path of necessary care offered by genetic counselors. Limitations significantly hamper the success of GWS in a genetic counseling setting, such as difficulties in obtaining consent for testing and data storage, the high rate of …

Clinicopathological Characteristics And Mutational Profile Of Kras And Nras Intunisian Patients With Sporadic Colorectal Cancer, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Meriam Hazgui, Saadia Bouraoui

Turkish Journal of Medical Sciences

Background/aim: Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia due to its increasing rate of incidence. KRAS and NRAS mutations have become a pivotal part of CRC diagnosis, given their association to treatment resistance with antiepidermal growth factor receptor (EGFR) monoclonal antibodies. In this study, we aimed to screen for mutations in KRAS and NRAS genes in Tunisian patients with CRC and explore their correlations with clinicopathological features. Materials and methods: AmoyDx KRAS and NRAS mutation real-time PCR kits were used to screen for mutations in KRAS (exon 2) and NRAS (exons 2, 3, and …

Can Urinary Biomarkers Predict Acute Kidney Injury In Newborns With Critical Congenitalheart Disease?, Özgün Uygur, Özge Altun Köroğlu, Reşi̇t Ertürk Levent, Eser Sözmen, Firat Ergi̇n, Yüksel Atay, Mehmet Yalaz, Mete Akisü, Ni̇lgün Kültürsay

Turkish Journal of Medical Sciences

Background/aim: Congenital heart disease (CHD) is the most common congenital malformation group and is the leading cause of newborn mortality in developed countries. Most of the infants with CHD develop preoperative or postoperative acute kidney injury (AKI). Acute kidney injury may develop before the serum creatinine rise and oliguria. Urinary biomarkers such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin (IL)-18, and cystatin C may predict AKI in patients with critical CHD (CCHD) before the serum creatinine rise. In this study, we aimed to determine the AKI incidence among newborn patients with CCHD and investigate the predictivity of …

The Evaluation Of Intracellular Energy Metabolism In Prediabetic Patients And Patientsnewly Diagnosed With Type 2 Diabetes Mellitus, Erkan Dulkadi̇roğlu, Hüseyi̇n Özden, Hüseyi̇n Demi̇rci̇

Turkish Journal of Medical Sciences

Background/aim: Increased susceptibility to infections is a serious problem in diabetics. Impairment in the energy metabolism of the immune system is the main source of the problem. Early diagnosis of the impairment in energy metabolism is crucial. Our study aimed to investigate the energy metabolism in leukocytes in patient groups such as prediabetics and patients newly diagnosed with type 2 diabetes mellitus. Materials and methods: Our study included 21 newly diagnosed type 2 diabetic patients (NDDP), 30 prediabetic patients, and 22 adult volunteers. 75 g oral glucose tolerance test (OGTT) was applied to all patients included in the study. Blood …

An Evaluation Of Suspected Cases Of Hantavirus Infection Admitted To A Tertiary Care University Hospital In Düzce, Turkey, Between 2012 And 2018, Nevi̇n İnce, Kürşad Öneç, Tansu Sav, Mehmet Ali̇ Sungur, Di̇lek Menemenli̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Hantavirus is a rodent borne zoonosis caused by the members of the virus family Bunyaviridae, genus Hantavirus. In this study, we aimed to determine the role of peripheral blood leukocyte ratio in differential diagnosis of Hantavirus disease. Materials and methods: The medical records of patients at the Düzce University Medical Faculty were examined retrospectively. A total of 20 patients diagnosed with hantavirus infection confirmed by serologic tests were included in the study (Group 1). The other group consisted of 30 patients suspected of hantavirus infection but found negative (Group 2). Demographic, clinical and laboratory characteristics, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte …

Validation Of The Nosas Score For Screening Sleep-Disordered Breathing: A Sleep Clinicbasedstudy In Turkey, Burcu Oktay Arslan, Zeynep Zeren Uçar, Özgür Batum, Mehmet Nurullah Orman

Turkish Journal of Medical Sciences

Background/aim: The NoSAS score is a new tool for the identification of high-risk patients for sleep-disordered breathing (SDB). The aim of this study was to validate the NoSAS score in a sleep clinical population in Turkey and compare its performance with the Epworth Sleepiness Scale (ESS), STOP-Bang, and Berlin questionnaires for high-risk SDB. Materials and methods: This was a retrospective study. Patients who had a full-night PSG examination between 01.03.2017 and 01.01.2018 at the sleep center of our hospital were included in the study. Demographic characteristics, anthropometrics measurements, ESS, STOP-Bang, and Berlin scores were collected from the existing data of …

Covid-19 Scientific Publications From Turkey, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu, Abdurrahman Tufan, Mehmet Aki̇f Öztürk

Turkish Journal of Medical Sciences

No abstract provided.

Development, Validity And Reliability Study Of A Compliance Scale For The Covid-19 Outbreak Prevention Recommendations, Eli̇f Köse, Esra Yazici, Ahmet Bülent Yazici, Abdülkadi̇r Aydin, Hasan Çeti̇n Ekerbi̇çer, Oğuz Karabay

Turkish Journal of Medical Sciences

Background/aim: During the intense periods of the COVID-19 pandemic, legal measures were taken for its containment. However, since legal precautions cannot be implemented continuously, hand washing, mask usage and obeying social distance rules are important in combating the pandemic. Complying with these rules is mostly individual decisions. The behavior of individuals has a prominent place in the course of the pandemic. In this study, we aimed to develop a scale which could measure compliance with outbreak measures. Materials and methods: This study was conducted in two stages after evaluation of the content validity of the item pool formed by the …

Could Serum Albumin Value And Thrombocyte/Lymphocyte Ratio Be An Importantprognostic Factor In Determining The Severity Of Covid 19?, Emel Uyar, Alparslan Merdi̇n, Serdar Yamanyar, Mehmet Can Ezgü, Cumhur Artuk, Gürhan Taşkin, Yakup Arslan, Serkan Ceri̇tli̇

Turkish Journal of Medical Sciences

Background and aim: Creating potential clinical markers for risk assessment in patients with COVID-19 continues to be an area of interest. In this study, we aimed to evaluate whether serum albumin level and thrombocyte/lymphocyte ratio are related to the severity of the disease. Materials and methods: The patients were divided into two groups according to the severity of disease. Demographic data, serum albumin value, lymphocyte count, TLO-1 values (thrombocyte/lymphocyte ratio-1), the highest thrombocyte count during hospitalization, TLO-2 (thrombocyte/lymphocyte ratio-2) values formed by the highest thrombocyte count, were recorded. Results: There was no statistically significant differences (P > 0.05) in terms of …

The Clinical Impact Of The Covid-19 Pandemic On Daily Urological Practice:First 3-Month Multicenter Results From İstanbul, Mehmet Çağlar Çakici, Mustafa Zafer Temi̇z, Ayberk İpli̇kçi̇, Faruk Özgör, Alper Kerem Aksoy, Murat Özer, Selçuk Erdem, İsmai̇l Ulus, Eyüp Veli̇ Küçük, Alper Ötünçtemur, Mehmet Enes Deği̇rmenci̇, Reşat Aydin, Ramazan Gökhan Atiş, Ahmet Yaser Müslümanoğlu, Ömer Sarilar

Turkish Journal of Medical Sciences

Background/aim: The aim of this paper was to determine the general tendencies of urology patients and effect of COVID-19 pandemic on daily urological practice at tertiary centers located in the most affected area in Turkey. Materials and methods: We retrospectively analyzed the data of 39,677 patients (group 1) that applied to 6 different large-volume tertiary centers in İstanbul for outpatient consultation, surgery, or other procedures in the 3-month period between March 16 and June 14, 2020. The distribution of the number of patients who applied to subspecialty sections of urology outpatient clinics and inpatient services were recorded by weeks. That …

Evaluation Of The Chest Computed Tomography And Hemogram Data In Patients Withcovid-19: The Importance Of Thymus, Vefa Çakmak, Atakan Yilmaz, Tuğba Sari, Pinar Çakmak, Mert Özen, Duygu Herek, Alten Oskay

Turkish Journal of Medical Sciences

Background/aim: To investigate the relationship between imaging findings and peripheral blood cell counts of COVID-19 patients and the degree of thymus fat involution of these patients. Materials and methods: Computed tomography (CT) images of 87 patients with COVID-19 positive through RT-PCR testing were evaluated retrospectively by two radiologists. Ground glass densities and other signs of viral pneumonia were recorded, lung involvement was scored quantitatively. The patients thymus fat involution was graded on CT. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratios (PLR), lymphocyte and platelet counts were calculated. Imaging findings and degrees of thymus fat involution were compared with laboratory data. Results: Quantitative …

The Relationship Of Extent Of Initial Radiological Involvement With The Need Of Intensivecare, Mortality Rates, And Laboratory Parameters In Covid-19, Yusuf Aydemi̇r, Yasemi̇n Gündüz, Mehmet Köroğlu, Oğuz Karabay, Hamad Dhei̇r, Aysun Şengül, Selçuk Yaylaci, Havva Kocayi̇ği̇t, Ali̇ Fuat Erdem, Özlem Aydemi̇r, Ertuğrul Güçlü, Yusuf Yürümez

Turkish Journal of Medical Sciences

Background/aim: It is very important for the efficient use of limited capacity and the success of treatment to predict patients who may need ICU with high mortality rate in the Covid-19 outbreak. In our study, it was aimed to investigate the value of the radiological involvement on initial CT in demonstrating the ICU transfer and mortality rate of patients. Materials and methods: All PCR-positive patients were included in the study, whose CT, PCR, and laboratory values were obtained simultaneously at the time of first admission. Patients were divided into 4 groups in terms of the extent of radiological lesions. These …

Epidemic Situation Of The Complex Seasonality Of Imported Influenza A And B Virustransmission In Guangxi Ports Of China, Xiangjuan Li, Zhongping Liang, Jie Gan, Lingmin Lu

Turkish Journal of Medical Sciences

Background/aim: Analysis of the characteristics of influenza virus in imported cases in Guangxi province of China. Materials and methods: Throat swabs of imported cases with influenza-like symptoms were detected by real-time PCR from July 2016 to December 2019. Results: 1292 laboratory detections of influenza were reported in 3974 influenza-like cases, of which 71.67% (926) were influenza A. The ratio of test positive was 32.82%. The proportion of detections of influenza B was 28.33% (366). A total of 70.51% of the cases mostly came from Vietnam (911). A total of 86.76% (1121) of the cases were imported from Dongxing Port, Nanning …