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2021

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The Relation Between Staging Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Metabolic Parameters And Tumor Necrosis Rate In Pediatricosteosarcoma Patients, Aykut Kürşat Fi̇dan, Güli̇n Uçmak, Bedri̇ye Büşra Demi̇rel, Hülya Efetürk, İpek Öztürk, Semra Demi̇rtaş Şenli̇k, Burcu Esen Akkaş, İnci̇ Ergürhan İlhan Jan 2021

The Relation Between Staging Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Metabolic Parameters And Tumor Necrosis Rate In Pediatricosteosarcoma Patients, Aykut Kürşat Fi̇dan, Güli̇n Uçmak, Bedri̇ye Büşra Demi̇rel, Hülya Efetürk, İpek Öztürk, Semra Demi̇rtaş Şenli̇k, Burcu Esen Akkaş, İnci̇ Ergürhan İlhan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the contribution of fluorine-18 (F-18) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging in staging of pediatric osteosarcoma patients and also to evaluate the ability of metabolic parameters from the primary tumor to predict tumor necrosis rate (TNR). Material and methods: F-18 FDG-PET/CT imaging was performed in staging 37 pediatric osteosarcoma patients. The metabolic parameters SUVmax (maximum standardised uptake value), MTV (metabolic tumour volume), and TLG (total lesion glycolysis) were measured from the primary tumor. TNR level of the primary tumor was histopathologically measured after standard neoadjuvant chemotherapy treatment. The contribution …

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The Effect Of Different Levels Of Pneumoperitoneum Pressures On Regional Cerebraloxygenation During Robotic Assisted Laparoscopic Prostatectomy, Arzu Karaveli̇, Ali̇ Sai̇t Kavakli, Murat Özçeli̇k, Mutlu Ateş, Kerem İnanoğlu, Sadik Özmen Jan 2021

The Effect Of Different Levels Of Pneumoperitoneum Pressures On Regional Cerebraloxygenation During Robotic Assisted Laparoscopic Prostatectomy, Arzu Karaveli̇, Ali̇ Sai̇t Kavakli, Murat Özçeli̇k, Mutlu Ateş, Kerem İnanoğlu, Sadik Özmen

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the effect of low- and high-pressure pneumoperitoneum pressures applied during robotic-assisted laparoscopic prostatectomy (RALP) using near-infrared spectroscopy (NIRS) on regional cerebral oxygenation saturation (rSO2 ). Materials and methods: The prospective, comparative, and observational study included patients aged 18-80 years, with the American Society of Anesthesiologists (ASA) physical status I-II, who would undergo elective RALP. The patients were divided into two groups (12 mmHg of pneumoperitoneum pressure group, n=22 and 15 mmHg of pneumoperitoneum pressure group, n=23). Patients' demographic data, durations of anesthesia, surgery, pneumoperitoneum, and Trendelenburg position, intraoperative estimated blood loss, fluid therapy, urine …

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Assessment Of Psychometric Properties, Cross-Cultural Adaptation, And Translation Of Theturkish Version Of The Icu Mobility Scale, İsmai̇l Özsoy, Buse Özcan Kahraman, Turhan Kahraman, Ayli̇n Tanriverdi̇, Serap Acar, Ebru Özpeli̇t, Bi̇hter Şentürk, Bahri̇ Akdeniz, Sema Savci Jan 2021

Assessment Of Psychometric Properties, Cross-Cultural Adaptation, And Translation Of Theturkish Version Of The Icu Mobility Scale, İsmai̇l Özsoy, Buse Özcan Kahraman, Turhan Kahraman, Ayli̇n Tanriverdi̇, Serap Acar, Ebru Özpeli̇t, Bi̇hter Şentürk, Bahri̇ Akdeniz, Sema Savci

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to carry out the cultural adaptation and translation of the ICU mobility scale (IMS) into Turkish and research the psychometric properties. Materials and methods: This study was based on methodological design. The IMS was translated from English to the Turkish through a regularised translation process. Two physiotherapists assessed patients independently in the coronary intensive care unit. The measures such as construct validity, intra and interrater reliability, and internal consistency of the IMS Turkish version were assessed. Results: A total of 70 intensive care patients were included in the study. The intrarater and interrater …

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Lticentered Study On Efficiency Of Noninvasive Ventilation Procedures(Safe-Niv), Ebru Ati̇ke Ongun, Oğuz Dursun, Ayşe Berna Anil, Ümüt Altuğ, Özlem Temel Köksoy, Başaknur Akyildiz, Serkan Özsoylu, Tanil Kendi̇rli̇, Serhan Özcan, Riza Di̇nçer Yildizdaş, İlknur Tolunay, Bülent Karapinar, Mehmet Arda Kilinç, Demet Demi̇rkol Jan 2021

Lticentered Study On Efficiency Of Noninvasive Ventilation Procedures(Safe-Niv), Ebru Ati̇ke Ongun, Oğuz Dursun, Ayşe Berna Anil, Ümüt Altuğ, Özlem Temel Köksoy, Başaknur Akyildiz, Serkan Özsoylu, Tanil Kendi̇rli̇, Serhan Özcan, Riza Di̇nçer Yildizdaş, İlknur Tolunay, Bülent Karapinar, Mehmet Arda Kilinç, Demet Demi̇rkol

Turkish Journal of Medical Sciences

Background/aim: To characterize the clinical course of noninvasive positive pressure ventilation (NIPPV) and high flow humidified nasal cannula ventilation (HFNC) procedures; perform risk analysis for ventilation failure. Material and methods: This prospective, multi-centered, observational study was conducted in 352 PICU admissions (1 month-18 years) between 2016 and 2017. SPSS-22 was used to assess clinical data, define thresholds for ventilation parameters and perform risk analysis. Results: Patient age, onset of disease, previous intubation and hypoxia influenced the choice of therapy mode: NIPPV was preferred in older children (p = 0.002) with longer intubation (p < 0.001), ARDS (p = 0.001), lower respiratory tract infections (p < 0.001), chronic respiratory disease, (p = 0.005), malignancy (p = 0.048) and immune deficiency (p = 0.026). The failure rate was 13.4%. sepsis, ARDS, prolonged intubation, and use of nasal masks were associated with NIV failure (p = 0.001, p < 0.001, p < 0.001, p = 0.025). The call of intubation or re-intubation was given due to respiratory failure in twenty-seven (57.5%), hemodynamic instability in eight (17%), bulbar dysfunction or aspiration in 5 (10.6%), neurological deterioration in 4 (8.5%) and developing ARDS in 3 (6.4%) children. A reduction of less than 10% in the respiration within an hour increased the odds of failure by 9.841 times (OR: 9.841, 95% CI: 2.0021-48.3742). FiO2 > 55% at 6th hours and PRISM-3 >8 …

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Neonatal Pneumothorax From The Perspective Of A Pediatric Surgeon: Classification Andmanagement Protocol: A Preliminary Algorithm., Mirzaman Huseynov, Ali̇ Ekber Hakalmaz Jan 2021

Neonatal Pneumothorax From The Perspective Of A Pediatric Surgeon: Classification Andmanagement Protocol: A Preliminary Algorithm., Mirzaman Huseynov, Ali̇ Ekber Hakalmaz

Turkish Journal of Medical Sciences

Background/aim: Current neonatal pneumothorax classifications based on air volume escaping in pleural space have no contribution on the treatment. Therefore, our aim was to classify neonatal pneumothorax to guide treatment management based on our experiences. Material and methods: The records of all neonates admitted to our clinics from March 2017 to August 2020 were reviewed. The patients with pneumothorax were identified through the neonatology department patient database search. The study only included the patients with symptomatic pneumothorax and these patients were evaluated into 3 groups based on the changes in peripheral oxygen saturation (SpO2 ) and clinical features immediately after …

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Evaluation Of The Learning Curve Of Pediatric Kidney Transplantation Anesthesia, Tümay Uludağ Yanaral, Peli̇n Karaaslan Jan 2021

Evaluation Of The Learning Curve Of Pediatric Kidney Transplantation Anesthesia, Tümay Uludağ Yanaral, Peli̇n Karaaslan

Turkish Journal of Medical Sciences

Background/aim: Pediatric kidney transplantation (PKT) anesthesia brings some different challenges than adult kidney transplantation (KT) anesthesia and there are still no studies analyzing the role of experience on PKT outcomes. In this study, we aimed to evaluate the anesthesia learning curve in pediatric kidney transplants performed in our institution and the effect of increasing experience on renal transplantation-related data. Materials and methods: Patients age ≤ 18 years who underwent KT were included in the study, while patients age >18 years were excluded. Patients were divided into 3 groups according to the date of transplant, as the first 10 patients in …

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The Role Of Lateralisation And Sex On Insular Cortex: 3d Volumetric Analysis, Fatma Öz, Ni̇yazi̇ Acer, Ni̇han Katayifçi, Güneş Aytaç, Kami̇l Karaali̇, Muzaffer Si̇ndel Jan 2021

The Role Of Lateralisation And Sex On Insular Cortex: 3d Volumetric Analysis, Fatma Öz, Ni̇yazi̇ Acer, Ni̇han Katayifçi, Güneş Aytaç, Kami̇l Karaali̇, Muzaffer Si̇ndel

Turkish Journal of Medical Sciences

Background/aim: The insula has attracted the attention of many neuroimaging studies because of its key role between brain structures. However, the number of studies investigating the effect of sex and laterality on insular volume is insufficient. The aim of this study was to investigate the differences in insular volume between sexes and hemispheres. Materials and methods: A total of 47 healthy participants [24 males (20.08 ± 1.44 years) and 23 females (19.57 ± 0.90 years)] underwent magnetic resonance imaging (MRI). Imaging was performed using the 3T MRI scanner. The insular volume was measured using the Individual Brain Atlases using Statistical …

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Clinical Predictors Of Drug-Resistant Epilepsy In Children, Paki̇ze Karaoğlu, Uluç Yi̇ş, Ayşe İpek Polat, Müge Ayanoğlu, Ayşe Semra Hiz Jan 2021

Clinical Predictors Of Drug-Resistant Epilepsy In Children, Paki̇ze Karaoğlu, Uluç Yi̇ş, Ayşe İpek Polat, Müge Ayanoğlu, Ayşe Semra Hiz

Turkish Journal of Medical Sciences

Background/aim: In up to 20% of epilepsy patients, seizures may not be controlled despite the use of antiepileptic drugs, either alone or in combination. These individuals are considered to have drug-resistant epilepsy. Drug-resistant epilepsy is usually associated with intellectual disability, psychiatric comorbidity, physical injury, sudden unexpected death, and low quality of life. Early detection and prediction of drug-resistant epilepsy are essential in determining the patient's most appropriate treatment option. This retrospective study aimed to determine the clinical, electroencephalographic, and radiological factors associated with medically intractable childhood seizures. Materials and methods: Data regarding 177 patients diagnosed with drug-resistant epilepsy were compared …

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Evaluation Of The Relationship Between Cranial Magnetic Resonance Imaging Findings Andclinical Status In Children With Cerebral Palsy, Ni̇han Şik, Fatma Ceren Sarioğlu, Özgür Özteki̇n, Berrak Sarioğlu Jan 2021

Evaluation Of The Relationship Between Cranial Magnetic Resonance Imaging Findings Andclinical Status In Children With Cerebral Palsy, Ni̇han Şik, Fatma Ceren Sarioğlu, Özgür Özteki̇n, Berrak Sarioğlu

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to evaluate the relationship between cranial magnetic resonance imaging (MRI) findings and clinical features in cerebral palsy (CP). Materials and methods: Children aged 3 to 18 years, who were followed with the diagnosis of CP between January 2012 and September 2015, were included. The type of CP was classified using the European Cerebral Palsy Monitoring Group's classification system and then, patients were divided into two groups as spastic or nonspastic groups. The Gross Motor Function Classification System (GMFCS) was used to determine the level of mobility. According to the GMFCS, levels 1, 2, …

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Comparison Of Local Infiltration Analgesia And Interscalene Block For Postoperative Painmanagement In Shoulder Arthroscopy: A Prospective Randomized Controlled Trial, Olgun Bi̇ngöl, Alper Deveci̇, Semi̇h Başkan, Güzelali̇ Özdemi̇r, Enver Kiliç, Emrah Arslantaş Jan 2021

Comparison Of Local Infiltration Analgesia And Interscalene Block For Postoperative Painmanagement In Shoulder Arthroscopy: A Prospective Randomized Controlled Trial, Olgun Bi̇ngöl, Alper Deveci̇, Semi̇h Başkan, Güzelali̇ Özdemi̇r, Enver Kiliç, Emrah Arslantaş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the effects of local infiltration analgesia and interscalene brachial plexus block techniques on postoperative pain control and shoulder functional scores in patients undergoing arthroscopic rotator cuff repair. Materials and methods: Sixty patients who underwent arthroscopic rotator cuff repair were prospectively included in the study. Patients were randomly divided into two groups. Group 1 was comprised of patients who had interscalene brachial plexus block, while group 2 was comprised of patients who had local infiltration analgesia. In group 1, interscalene block was applied with 20 mL 0.5% bupivacaine. In group 2, the …

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Circumcision With Plastic Alisclamp Technique In 4733 Boys: Our Experiences To Reducecomplications, Alev Süzen, Süleyman Cüneyt Karakuş, Nazi̇le Ertürk Jan 2021

Circumcision With Plastic Alisclamp Technique In 4733 Boys: Our Experiences To Reducecomplications, Alev Süzen, Süleyman Cüneyt Karakuş, Nazi̇le Ertürk

Turkish Journal of Medical Sciences

Background/aim: We aim to report the outcomes of circumcisions performed with Alisclamp and our experiences to reduce the complications. Material and methods: Complications among circumcised males with Alisclamp between 2015 and 2018 were retrospectively analyzed. Patients were divided into two groups: Group 1 (n = 1429); patients circumcised in 2015-2016 and Group 2 (n = 3304); patients circumcised in 2017-2018. The different technical approaches in Group 2 are as follows: 1) Prevention of bleeding: In Group 2, we didn't pull the ventral prepuce to reduce the risk of frenulum injury and the foreskin was excised approximately 1-2 mm above the …

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Retrospective Evaluation Of The Pediatric Multicystic Dysplastic Kidney Patients:Experience Of Two Centers From Southeastern Turkey, Mehtap Akbalik Kara, Aysel Taktak, Caner Alparslan Jan 2021

Retrospective Evaluation Of The Pediatric Multicystic Dysplastic Kidney Patients:Experience Of Two Centers From Southeastern Turkey, Mehtap Akbalik Kara, Aysel Taktak, Caner Alparslan

Turkish Journal of Medical Sciences

Background/aim: The objective of this study is to determine the clinical features of unilateral multicystic dysplastic kidney (MCDK) patients. Materials and methods: The demographic, clinical, laboratory, and radiologic features of MCDK patients at Diyarbakır Children's Hospital and Diyarbakır Gazi Yaşargil Training and Research Hospital between January 2008-June 2019 were retrospectively evaluated. Results: A total of 111 [59 (53.2%) male and 52(46.8%) female] patients with MCDK were followed for a mean period of 41.89 ± 32.03 months. MCDK was located on the left and right sides in 46 (41.4%) and 65 (58.6%) of the children, respectively (p > 0.05). A total of …

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The Assessment Of The Effect Of Different Intraabdominal Pressures Used For Laparoscopiccholecystectomy Surgery On Optic Nerve Sheath Diameter: A Prospective Observationalcohort Study, Tuna Ertürk, Bülent Bariş Güven, Yadi̇gar Yilmaz Camgöz, Fulya Yurtsever, Ayşin Ersoy Jan 2021

The Assessment Of The Effect Of Different Intraabdominal Pressures Used For Laparoscopiccholecystectomy Surgery On Optic Nerve Sheath Diameter: A Prospective Observationalcohort Study, Tuna Ertürk, Bülent Bariş Güven, Yadi̇gar Yilmaz Camgöz, Fulya Yurtsever, Ayşin Ersoy

Turkish Journal of Medical Sciences

Background/aim: During laparoscopic cholecystectomy operations, increases in intraabdominal, intrathoracic, and intracranial pressures (ICP) can be seen after pneumoperitoneum created for surgical imaging. Orbital ultrasonography (USG), which has been developed in recent years, is a method that can evaluate the ICP by measuring the optic nerve sheath diameter (ONSD) from the eyeball. In our study, we aimed to evaluate whether different intraabdominal pressure values created during laparoscopic cholecystectomy operations correlate with ICP by measuring ONSD. Materials and methods: The study included a total of 90 patients with American Society of Anesthesiologists (ASA) physical status classification I (ASA I) and II (ASA …

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The Association Between Mrna Expression Of Resistin, Tnf- Α, Il-6, Il-8, And Er-Α Inperipheral Blood Mononuclear Cells And Breast Cancer, Masome Zare-Moayedi, Fatame Ahmmadpour, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amirahmad Salmasi, Ghorban Mohammadzadeh Jan 2021

The Association Between Mrna Expression Of Resistin, Tnf- Α, Il-6, Il-8, And Er-Α Inperipheral Blood Mononuclear Cells And Breast Cancer, Masome Zare-Moayedi, Fatame Ahmmadpour, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amirahmad Salmasi, Ghorban Mohammadzadeh

Turkish Journal of Medical Sciences

Background/aim: Adipocytokines, adipose tissue-derived proteins, were demonstrated to be involved in the pathogenesis of breast cancer. We assessed the mRNA expression of resistin, tumor necrosis factor-alpha (TNF-α), interleukins 6 and 8 (IL-6, and IL-8), and estrogen receptor alpha (ER-α) in peripheral blood mononuclear cells (PBMCs) of women with and without breast cancer. Materials and methods: The PBMCs were isolated from the whole blood of 32 women with breast cancer and 18 women without breast cancer using density gradient centrifugation. The mRNA expression of the target genes was measured by reverse-transcription polymerase chain reaction (RT-PCR). Body mass index was calculated, additionally, …

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The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç Jan 2021

The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç

Turkish Journal of Medical Sciences

Background/aim: Targeting the new and unique proteins is an important medical strategy for treating breast cancer. It is quite important to find out proteins that have a role in the development of cancer. Sirtuins (SIRT) are well related in different physiological activities and connected with cancer. We aimed to determine the effect of radiotherapy on SIRT1 and SIRT2, which have not been yet been clarified as a tumor suppressor or promoter. Materials and methods: Twenty-two women with nonmetastatic breast cancer enrolled in the study. Blood samples were taken before and after radiotherapy, soluble SIRT1 and SIRT2 levels were determined with …

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Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş Jan 2021

Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş

Turkish Journal of Medical Sciences

Background/aim: Magnetic resonance (MR) images, signal intensity ratios calculated using region of interests (ROI) in T2W images by proportioning the dominant myoma to iliac muscle can aid patient selection and, thus, in achieving better outcomes with the uterine artery embolization (UAE) procedure. The present study investigates the association between the success of UAE treatment with signal intensity (SI) ratio of the dominant myoma to the iliac muscle in MR imaging performed prior to the procedure. Materials and methods: This is a retrospective study and included 30 patients who admitted to our clinic between February 2017 and July 2019 due to …

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Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun Jan 2021

Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun

Turkish Journal of Medical Sciences

Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in …

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Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş Jan 2021

Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the effect of vitamin D supplementation on ambulation and mobility in hospitalized patients undergoing stroke rehabilitation. Materials and methods: This study was conducted retrospectively between September 2020 and October 2020 at Gazi University Faculty of Medicine Physical Medicine and Rehabilitation Department. Seventy-six patients who received inpatient stroke rehabilitation treatment between May 2018 and February 2020 were included in the study. The patients were divided into two groups as those who did and did not take vitamin D supplements. Lower extremity motor function and ambulation status were compared using Brunnstrom recovery stage …

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Sequential Analysis Of Single-Center Experience Of Living Donor Kidney Transplants Withseveral Vascular Anastomosis Techniques, Berri̇n Papi̇la Kundaktepe, Ali̇ Vedat Durgun, Ertuğrul Göksoy, Sali̇h Pekmezci̇, Meti̇n Kapan, Kaya Saribeyoğlu, Mehmet Veli̇dedeoğlu, Mehmet Eli̇çevi̇k Jan 2021

Sequential Analysis Of Single-Center Experience Of Living Donor Kidney Transplants Withseveral Vascular Anastomosis Techniques, Berri̇n Papi̇la Kundaktepe, Ali̇ Vedat Durgun, Ertuğrul Göksoy, Sali̇h Pekmezci̇, Meti̇n Kapan, Kaya Saribeyoğlu, Mehmet Veli̇dedeoğlu, Mehmet Eli̇çevi̇k

Turkish Journal of Medical Sciences

Background and aim: Vascular variations of grafts are handled with various reconstruction techniques in renal transplantation. We aimed to analyze the effects of these reconstruction techniques and sites on patient/graft outcomes. Materials and methods: Renal transplantation cases at the Transplantation Unit of the General Surgery Department, İstanbul University Cerrahpaşa Medical Faculty between January 1st, 2000 and December 31st, 2012 were analyzed retrospectively. Postoperative duplex ultrasound results, urea-creatinine reduction rates, and complications were evaluated. Results: There were 228 living-donor transplantation cases evaluated. For single-renal-artery living-donor transplantations, there were 45 end-to-side external iliac artery, 15 end-to-side internal iliac artery, 152 end-to-end internal …

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Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya Jan 2021

Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya

Turkish Journal of Medical Sciences

Background/aim: The prevalence of Helicobacter pylori is reported to be roughly 80% in Turkey, and only very few culture-based studies are available on antibacterial resistance in adult dyspeptic patients. This study was carried out in adult dyspeptic patients with an aim to: (i) detect H. pylori by invasive tests (culture, polymerase chain reaction, and histopathology) and (ii) determine the current resistance rates of H. pylori isolates to six antibiotics, including rifampicin. Materials and methods: This study was conducted in 422 adult dyspeptic patients. The presence of H. pylori was demonstrated by culture, polymerase chain reaction, and the histopathology of gastric …

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The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe Jan 2021

The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe

Turkish Journal of Medical Sciences

Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …

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Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk Jan 2021

Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk

Turkish Journal of Medical Sciences

Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in …

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Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel Jan 2021

Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel

Turkish Journal of Medical Sciences

Background/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In GroupII, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and endto-end anastomosis was performed. In Group-IV, …

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Sars-Cov-2 Associated Rhabdomyolysis In 32 Patients, Josef Finsterer, Fulvio Scorza Jan 2021

Sars-Cov-2 Associated Rhabdomyolysis In 32 Patients, Josef Finsterer, Fulvio Scorza

Turkish Journal of Medical Sciences

Background/aim: This mini-review aims at summarising and discussing previous and recent findings concerning the clinical manifestations, therapeutic management, and outcome of SARS-CoV-2 associated rhabdomyolysis. Materials and methods: Literature search in the PubMed database by applying appropriate search terms. Results: A total of 26 articles reporting SARS-CoV-2 associated rhabdomyolysis in 32 patients were identified. Age ranged from 16 to 80 years. Four patients were female and 25 were male. Onset of rhabdomyolysis was prior to onset of COVID-19 in 7 patients, and after onset of COVID-19 in the remaining patients. Exposure to myotoxic medication was identified in 18 patients. Myotoxic drugs …

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The Clinical Course Of Covid-19 In Hematopoietic Stem Cell Transplantation (Hsct)Recipients, Ayşe Karataş, Ümi̇t Yavuz Malkan, Mustafa Velet, Haluk Demi̇roğlu, Yahya Büyükaşik, Gülçi̇n Telli̇ Di̇zman, Ahmet Çağkan İnkaya, Batuhan Erdoğdu, Olgu Erki̇n Çinar, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Ni̇lgün Sayinalp, Hakan Göker Jan 2021

The Clinical Course Of Covid-19 In Hematopoietic Stem Cell Transplantation (Hsct)Recipients, Ayşe Karataş, Ümi̇t Yavuz Malkan, Mustafa Velet, Haluk Demi̇roğlu, Yahya Büyükaşik, Gülçi̇n Telli̇ Di̇zman, Ahmet Çağkan İnkaya, Batuhan Erdoğdu, Olgu Erki̇n Çinar, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, İbrahi̇m Celaletti̇n Haznedaroğlu, Osman İlhami̇ Özcebe, Ni̇lgün Sayinalp, Hakan Göker

Turkish Journal of Medical Sciences

Background/aim: The disease caused by SARS-CoV-2 was named as COVID-19. There is as yet insufficient information about the effects of HSCT on the clinical course of COVID-19. In the present study, we aimed to investigate the clinical course of COVID-19 in patients who had undergone HSCT. Materials and methods: We analyzed baseline characteristics, clinical course and findings of COVID-19, hospitalization and death rates, overall survival, and case fatality rates of HSCT recipients diagnosed with COVID-19 retrospectively. Results: 57.6% of the patients underwent AHSCT, and 42.4% underwent allo-HSCT. 60.6%, 27.3%, and 12.1% of the patients had mild, moderate, and severe COVID-19 …

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First Known Covid-19 Case And Contact Tracing Efforts In İstanbul, Turkey, Abdullah Emre Güner, Aral Sürmeli̇, Kemal Kural, Esra Şahi̇n, Peri̇han Alkan, Erdoğan Kocayi̇ği̇t, Mustafa Hati̇poğlu, Şuayip Bi̇ri̇nci̇, Kemal Memi̇şoğlu, Işil Maral Jan 2021

First Known Covid-19 Case And Contact Tracing Efforts In İstanbul, Turkey, Abdullah Emre Güner, Aral Sürmeli̇, Kemal Kural, Esra Şahi̇n, Peri̇han Alkan, Erdoğan Kocayi̇ği̇t, Mustafa Hati̇poğlu, Şuayip Bi̇ri̇nci̇, Kemal Memi̇şoğlu, Işil Maral

Turkish Journal of Medical Sciences

Background/aim: COVID-19 has now become a global pandemic. Understanding the routes of transmission is vital in the mitigation and suppression of the disease. İstanbul has become one of the disease's epicenters. This study aims to describe the first COVID-19 case and contact tracing efforts around it in İstanbul. Materials and methods: The descriptive study was conducted in İstanbul, Turkey. The first COVID-19 cases and those associated with them were investigated with contact tracing, and primary and secondary cases were described. Results: The source case was an individual who returned to Turkey from international travel at the beginning of March and …

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Phenotypic Characterization Of Familial Mediterranean Fever Patients Harboring Variantsof Uncertain Significance, Alper Sari, Erdal Bodakçi̇, Berkan Armağan, Hasan Satiş, Nuh Ataş, Nazi̇fe Şule Yaşar Bi̇lge, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Umut Kalyoncu, Ti̇muçi̇n Kaşi̇foğlu Jan 2021

Phenotypic Characterization Of Familial Mediterranean Fever Patients Harboring Variantsof Uncertain Significance, Alper Sari, Erdal Bodakçi̇, Berkan Armağan, Hasan Satiş, Nuh Ataş, Nazi̇fe Şule Yaşar Bi̇lge, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Umut Kalyoncu, Ti̇muçi̇n Kaşi̇foğlu

Turkish Journal of Medical Sciences

Background/aim: Familial Mediterranean Fever (FMF) is the prototype of hereditary autoinflammatory disorders and caused by mutations on the MEFV gene located on the short arm of chromosome 16. Although some MEFV variants are clearly associated with disease phenotype, there are numerous variants with unknown clinical association which are termed as variants of uncertain significance (VUS). Here, we present clinical correlations of VUS in a large cohort of adult FMF patients from three tertiary centers located in Central Anatolia. Materials and methods: All patients were recruited from FMF in Central Anatolia (FiCA) cohort. Demographic (sex, age at disease onset) and clinical …

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Mefv Mutation Frequencies In A Turkish Cohort With Low Prevalence Of Familialmediterranean Fever, Necati̇ Çakir, Hülya Azakli, Duran Üstek, Ömer Uysal, Eren Gözke Jan 2021

Mefv Mutation Frequencies In A Turkish Cohort With Low Prevalence Of Familialmediterranean Fever, Necati̇ Çakir, Hülya Azakli, Duran Üstek, Ömer Uysal, Eren Gözke

Turkish Journal of Medical Sciences

Background/aim: Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey. Materials and methods: The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene. Results: In total, 25 of the 263 individuals carried MEFV mutations (9.5%). …

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Folfirinox Versus Gemcitabine-Cisplatin Combination As First-Line Therapy Intreatment Of Pancreaticobiliary Cancer, Nesli̇han Kayahan Satiş, Mustafa Karaca, Hasan Satiş, Di̇lek Yapar, Ahmet Özet Jan 2021

Folfirinox Versus Gemcitabine-Cisplatin Combination As First-Line Therapy Intreatment Of Pancreaticobiliary Cancer, Nesli̇han Kayahan Satiş, Mustafa Karaca, Hasan Satiş, Di̇lek Yapar, Ahmet Özet

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to compare efficacy and safety of a combination chemotherapy regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine-cisplatin as first-line therapy in patients with pancreatic cancer. Materials and methods: Pancreaticobiliary cancer patients who had Eastern Cooperative Oncology Group performance status score of 0 or 1 (on a scale of 0 to 5, with higher scores indicating greater severity of illness) were evaluated to receive folfirinox or gemcitabine plus cisplatin. The primary endpoints were progression-free and overall survival time. Safety analysis was also evaluated as secondary measures. Results: There were 32 patients …

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The Frequency Of Achilles And Plantar Calcaneal Spurs In Gout Patients, Emi̇ne Duran, Emre Bi̇lgi̇n, Ali̇ İhsan Ertenli̇, Umut Kalyoncu Jan 2021

The Frequency Of Achilles And Plantar Calcaneal Spurs In Gout Patients, Emi̇ne Duran, Emre Bi̇lgi̇n, Ali̇ İhsan Ertenli̇, Umut Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: Gout may cause various radiographic abnormalities such as cartilage loss, spurs, sclerosis, and periostal new bone formation. The purpose of this study was to investigate the frequency of Achilles and plantar spurs and related factors in gout patients. Matherial and methods: We performed a retrospective review of gout patients, treated at Hacettepe University hospitals between 2014 and 2019. We identified patients from the hospital records using the ICD-10 code (M10). Demographic and clinical features, comorbidities, and foot radiographies were collected. The radiographies were evaluated by a rheumatologist (U.K.) who was experienced in musculoskeletal radiography. Factors predicting the spurs were …

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