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2021

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Evaluating The Energetics Of Entrainment In A Human–Machine Coupled Oscillator System, Ryan T. Schroeder, James L. Croft, John E. A. Bertram Jan 2021

Evaluating The Energetics Of Entrainment In A Human–Machine Coupled Oscillator System, Ryan T. Schroeder, James L. Croft, John E. A. Bertram

Research outputs 2014 to 2021

During locomotion, humans sometimes entrain (i.e. synchronize) their steps to external oscillations: e.g. swaying bridges, tandem walking, bouncy harnesses, vibrating treadmills, exoskeletons. Previous studies have discussed the role of nonlinear oscillators (e.g. central pattern generators) in facilitating entrainment. However, the energetics of such interactions are unknown. Given substantial evidence that humans prioritize economy during locomotion, we tested whether reduced metabolic expenditure is associated with human entrainment to vertical force oscillations, where frequency and amplitude were prescribed via a custom mechatronics system during walking. Although metabolic cost was not significantly reduced during entrainment, individuals expended less energy when the oscillation forces …


Natural Habitat Of Bali Starling (Leucopsar Rothschildi) In Bali Barat National Park, Indonesia, Sutomo Sutomo, Eddie Van Etten Jan 2021

Natural Habitat Of Bali Starling (Leucopsar Rothschildi) In Bali Barat National Park, Indonesia, Sutomo Sutomo, Eddie Van Etten

Research outputs 2014 to 2021

The Indonesian tropical savannas and dry forests provide habitats to various endemic wildlife. Unfortunately, a few of these endemic species are now seriously threatened and are red listed in the conservation status of International Union for Conservation of Nature (IUCN). Among these species, the Bali starling or Bali mynah Leucopsar rotschildi, locally known as Jalak Bali, is now mostly restricted to the Bali Barat National Park. Given the high extinction risk faced by such species, conservation programs require multidisciplinary approaches that would address both the biological attributes of the species itself and their habitat requirements. Regrettably, for many species, their …


Prevalence And Patterns Of Multimorbidity In Australian Baby Boomers: The Busselton Healthy Ageing Study, Michael L. Hunter, Matthew W. Knuiman, Bill A. W. Musk, Jennie Hui, Kevin Murray, John P. Beilby, David R. Hillman, Joseph Hung, Robert U. Newton, Romola S. Bucks, Leon Straker, John P. Walsh, Kun Zhu, David G. Bruce, Robert H. Eikelboom, Timothy M. E. Davis, David A. Mackey, Alan L. James Jan 2021

Prevalence And Patterns Of Multimorbidity In Australian Baby Boomers: The Busselton Healthy Ageing Study, Michael L. Hunter, Matthew W. Knuiman, Bill A. W. Musk, Jennie Hui, Kevin Murray, John P. Beilby, David R. Hillman, Joseph Hung, Robert U. Newton, Romola S. Bucks, Leon Straker, John P. Walsh, Kun Zhu, David G. Bruce, Robert H. Eikelboom, Timothy M. E. Davis, David A. Mackey, Alan L. James

Research outputs 2014 to 2021

Background and objective: Chronic medical conditions accumulate within individuals with age. However, knowledge concerning the trends, patterns and determinants of multimorbidity remains limited. This study assessed the prevalence and patterns of multimorbidity using extensive individual phenotyping in a general population of Australian middle-aged adults. Methods: Participants (n = 5029, 55% female), born between 1946 and 1964 and attending the cross-sectional phase of the Busselton Healthy Ageing Study (BHAS) between 2010 and 2015, were studied. Prevalence of 21 chronic conditions was estimated using clinical measurement, validated instrument scores and/or self-reported doctor-diagnosis. Non-random patterns of multimorbidity were explored using observed/expected (O/E) prevalence …


Feasibility, Tolerance And Effects Of Adding Impact Loading Exercise To Pulmonary Rehabilitation In People With Chronic Obstructive Pulmonary Disease: Study Protocol For A Pilot Randomised Controlled Trial, Erin Cecins, Kylie Hill, Dennis R. Taaffe, David Manners, Anne-Marie Hill, Robert U. Newton, Daniel A. Galvão, Vinicius Cavalheri Jan 2021

Feasibility, Tolerance And Effects Of Adding Impact Loading Exercise To Pulmonary Rehabilitation In People With Chronic Obstructive Pulmonary Disease: Study Protocol For A Pilot Randomised Controlled Trial, Erin Cecins, Kylie Hill, Dennis R. Taaffe, David Manners, Anne-Marie Hill, Robert U. Newton, Daniel A. Galvão, Vinicius Cavalheri

Research outputs 2014 to 2021

Background:

Chronic obstructive pulmonary disease (COPD) is a disorder linked with a multitude of extra pulmonary manifestations (also known as treatable traits), including low bone mineral density (BMD). To date, no specific guidelines exist for the management of BMD in this population. Impact loading exercise has been identified as an intervention that improves or maintains BMD in other populations. However, the feasibility of and tolerance to impact loading exercise has not been tested in people with COPD. The aim of the proposed study will be to investigate the feasibility and tolerance of adding impact loading exercise to a standard pulmonary …


Effects Of Exercise During Radiotherapy On Physical Function And Treatment-Related Side Effects In Men With Prostate Cancer: A Systematic Review And Meta-Analysis, Oliver Schumacher, Hao Luo, Dennis Taaffe, Daniel A. Galvao, Colin Tang, Raphael Chee, Nigel Spry, Robert Newton Jan 2021

Effects Of Exercise During Radiotherapy On Physical Function And Treatment-Related Side Effects In Men With Prostate Cancer: A Systematic Review And Meta-Analysis, Oliver Schumacher, Hao Luo, Dennis Taaffe, Daniel A. Galvao, Colin Tang, Raphael Chee, Nigel Spry, Robert Newton

Research outputs 2014 to 2021

Purpose

Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to mitigate radiation therapy–related fatigue in men with prostate cancer during radiation therapy, other adverse effects of treatment such as physical deconditioning, urinary symptoms, or sexual dysfunction have not been systematically reviewed in this patient population. Thus, the purpose of this review was to investigate the effect of exercise on physical function and treatment-related side effects in men with prostate cancer undergoing radiation therapy.

Methods

A …


Directions For Research Practice In Decolonising Methodologies: Contending With Paradox, Tamara A. Lipscombe, Antonia Hendrick, Peta L. Dzidic, Darren C. Garvey, Brian Bishop Jan 2021

Directions For Research Practice In Decolonising Methodologies: Contending With Paradox, Tamara A. Lipscombe, Antonia Hendrick, Peta L. Dzidic, Darren C. Garvey, Brian Bishop

Research outputs 2014 to 2021

The complex nature of colonisation presents with the potential for paradoxes in decolonising approaches, hence, fixed conventions and methods are discouraged. In this way, decolonising methodologies concerns interrogating dominant conventions in research that have typically excluded alternative ways of knowing from academia. This raises concern about the issue of breaking conventions, when it is potentially difficult to realise that one is depending upon them. An incremental approach to the research process and subsequent knowledge generated provides opportunity to challenge the conventions that typically dictate research praxis. In addition, fostering epistemological transformation and pluralism presents a solution to problems derived from …


Effect Of Co2 Flooding On The Wettability Evolution Of Sand-Stone, Cut Aja Fauziah, Ahmed Al-Yaseri, Emad Al-Khdheeawi, Nilesh Kumar Jha, Hussein R. Abid, Stefan Iglauer, Christopher Lagat, Ahmed Barifcani Jan 2021

Effect Of Co2 Flooding On The Wettability Evolution Of Sand-Stone, Cut Aja Fauziah, Ahmed Al-Yaseri, Emad Al-Khdheeawi, Nilesh Kumar Jha, Hussein R. Abid, Stefan Iglauer, Christopher Lagat, Ahmed Barifcani

Research outputs 2014 to 2021

Wettability is one of the main parameters controlling CO2 injectivity and the movement of CO2 plume during geological CO2 sequestration. Despite significant research efforts, there is still a high uncertainty associated with the wettability of CO2/brine/rock systems and how they evolve with CO2 exposure. This study, therefore, aims to measure the contact angle of sandstone samples with varying clay content before and after laboratory core flooding at different reservoir pressures, of 10 MPa and 15 MPa, and a temperature of 323 K. The samples’ microstructural changes are also assessed to investigate any potential alteration …


Profile Of Immunoglobulin G N-Glycome In Covid-19 Patients: A Case-Control Study, Haifeng Hou, Huan Yang, Pengcheng Liu, Changwu Huang, Meng Wang, Yuejin Li, Mingsong Zhu, Jing Wang, Yuan Xu, Youxin Wang, Qingwei Ma, Dong Li, Pu Liao, Wei Wang Jan 2021

Profile Of Immunoglobulin G N-Glycome In Covid-19 Patients: A Case-Control Study, Haifeng Hou, Huan Yang, Pengcheng Liu, Changwu Huang, Meng Wang, Yuejin Li, Mingsong Zhu, Jing Wang, Yuan Xu, Youxin Wang, Qingwei Ma, Dong Li, Pu Liao, Wei Wang

Research outputs 2014 to 2021

Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in …


Pattern And Degree Of Individual Brain Atrophy Predicts Dementia Onset In Dominantly Inherited Alzheimer's Disease, Ophir Keret, Adam M. Staffaroni, John M. Ringman, Yann Cobigo, Sheng-Yang M. Goh, Amy Wolf, Isabel Elaine Allen, Stephen Salloway, Jasmeer Chhatwal, Adam M. Brickman, Dolly Reyes-Dumeyer, Randal J. Bateman, Tammie L.S. Benzinger, John C. Morris, Beau M. Ances, Nelly Joeseph-Mathurin, Richard J. Perrin, Brian A. Gordon, Johannes Levin, Jonathan Voglein, Mathias Jucker, Christian La Fougere, Ralph N. Martins, Hamid R. Sohrabi, Kevin Taddei, Victor L. Villemagne, Peter R. Schofield, William S. Brooks, Michael Fulham, Colin L. Masters, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Neill R. Graff-Radford, Michael Weiner, David M. Cash, Ricardo F. Allegri, Patricio Chrem, Su Yi, Bruce L. Miller, Gil D. Rabinovici, Howard J. Rosen, Dominantly Inherited Alzheimer Network Jan 2021

Pattern And Degree Of Individual Brain Atrophy Predicts Dementia Onset In Dominantly Inherited Alzheimer's Disease, Ophir Keret, Adam M. Staffaroni, John M. Ringman, Yann Cobigo, Sheng-Yang M. Goh, Amy Wolf, Isabel Elaine Allen, Stephen Salloway, Jasmeer Chhatwal, Adam M. Brickman, Dolly Reyes-Dumeyer, Randal J. Bateman, Tammie L.S. Benzinger, John C. Morris, Beau M. Ances, Nelly Joeseph-Mathurin, Richard J. Perrin, Brian A. Gordon, Johannes Levin, Jonathan Voglein, Mathias Jucker, Christian La Fougere, Ralph N. Martins, Hamid R. Sohrabi, Kevin Taddei, Victor L. Villemagne, Peter R. Schofield, William S. Brooks, Michael Fulham, Colin L. Masters, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Neill R. Graff-Radford, Michael Weiner, David M. Cash, Ricardo F. Allegri, Patricio Chrem, Su Yi, Bruce L. Miller, Gil D. Rabinovici, Howard J. Rosen, Dominantly Inherited Alzheimer Network

Research outputs 2014 to 2021

Introduction: Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment. Methods: We created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally. Results: Our risk score separated asymptomatic versus demented …


Graphene Nanoplatelets Suspended In Different Basefluids Based Solar Collector: An Experimental And Analytical Study, Omer A. Alawi, Haslinda Mohamed Kamar, Abdul Rahman Mallah, Hussein A. Mohammed, Mohd Aizad Sazrul Sabrudin, Omar A. Hussein, Salim Newaz Kazi, Gholamhassan Najafi Jan 2021

Graphene Nanoplatelets Suspended In Different Basefluids Based Solar Collector: An Experimental And Analytical Study, Omer A. Alawi, Haslinda Mohamed Kamar, Abdul Rahman Mallah, Hussein A. Mohammed, Mohd Aizad Sazrul Sabrudin, Omar A. Hussein, Salim Newaz Kazi, Gholamhassan Najafi

Research outputs 2014 to 2021

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. A flat plate solar collector (FPSC) was analytically studied, with functionalized graphene nanoplatelets (f-GNPs) as its working fluid. Four samples (wt % nanofluids) were prepared in different base fluids such as ethylene glycol (EG), distilled water (DW):EG (70:30), and DW:EG (50:50). Experimental results (via DW) were used to verify the effectiveness of the analytical model. Some of the operating conditions were taken into account in this research, including temperatures, power, and mass flow rates. Experimental techniques were used to elucidate the modified nanofluids’ physicochemical properties, such as its particle sizes, stability, …


Accessing The Effect Of Renewables On The Wholesale Power Market, Mohammad Nure Alam Jan 2021

Accessing The Effect Of Renewables On The Wholesale Power Market, Mohammad Nure Alam

Research outputs 2014 to 2021

© 2021, Econjournals. All rights reserved. The purpose of this paper is to examine how rising wind energy generation (in MWh) impact the wholesale power market’s volatility (in SEK) across four bidding regions in Sweden. Prior investigations show that though the increase in electricity production from wind energy lowers the average day-ahead electricity wholesale prices, however, uncertainty and volatility of market price could rise due to wind energy’s intermittent nature. This study results show that Swedish power market experiences higher price volatility in long-run frequency when the generation of wind electricity increases. The reason for this high and volatile electricity …


Associating Psychological Factors With Workplace Satisfaction And Position Duration In A Sample Of International School Teachers, Ross C. Hollett, Mark Mcmahon, Ronald Monson Jan 2021

Associating Psychological Factors With Workplace Satisfaction And Position Duration In A Sample Of International School Teachers, Ross C. Hollett, Mark Mcmahon, Ronald Monson

Research outputs 2014 to 2021

© Copyright © 2021 Hollett, McMahon and Monson. To be an effective teacher, a combination of specific professional skills and psychological attributes are required. With increasingly fluid employment conditions, particularly in the international context, recruiters and schools are under considerable pressure to quickly differentiate candidates and make successful placements, which involves more than just determining if a candidate holds an appropriate qualification. Therefore, the aim of this cross-sectional study was to measure theoretically and empirically valuable psychological attributes in an international sample of schoolteachers to determine the most valuable correlates of satisfaction and position duration. An international sample (N = …


Judges’ Evaluation Reliability Changes Between Identifiable And Anonymous Performance Of Hip-Hop Dance Movements, Nahoko Sato, Luke S. Hopper Jan 2021

Judges’ Evaluation Reliability Changes Between Identifiable And Anonymous Performance Of Hip-Hop Dance Movements, Nahoko Sato, Luke S. Hopper

Research outputs 2014 to 2021

© 2021 Sato, Hopper. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hip-hop competitions are performed across the world. In the recent inclusion in the 2018 Youth Olympic Games, the assessment of hip-hop performance is undertaken by a panel of judges. The purpose of this study was to determine the reliability of different visualisation tools utilised in the assessment of the hip-hop dance movements. Ten dancers performed basic rhythmic hip-hop movements which were captured …


Injury Deaths In Australian Sport And Recreation: Identifying And Assessing Priorities For Prevention, Lauren V. Fortington, Andrew S. Mcintosh, Caroline F. Finch Jan 2021

Injury Deaths In Australian Sport And Recreation: Identifying And Assessing Priorities For Prevention, Lauren V. Fortington, Andrew S. Mcintosh, Caroline F. Finch

Research outputs 2014 to 2021

Introduction

Sport and recreation is beneficial for health and wellbeing but comes with a probability of loss, including occasional fatal injuries. Following high-profile injury deaths in Australia, concerns are raised regarding the safety of sport participation. To understand the scale and scope of injury deaths, and identify potential prevention opportunities, the aim of this investigation was to describe the number and nature of fatal injuries in Australian sport and recreation.

Methods

This is a retrospective cohort study of injury deaths reported between 1 July 2000 to 31 December 2019 using data from the National Coronial Information System, Australia. Unintentional deaths …


Editorial: Hexagonal Close-Packed Metals And Alloys: Processing, Microstructure And Properties, Liang-Yu Chen, Linjiang Chai, Lai-Chang Zhang Jan 2021

Editorial: Hexagonal Close-Packed Metals And Alloys: Processing, Microstructure And Properties, Liang-Yu Chen, Linjiang Chai, Lai-Chang Zhang

Research outputs 2014 to 2021

In comparison with face-centered cubic (FCC) and body-centered cubic (BCC) metals and alloys, hexagonal close-packed (HCP) metals and alloys show distinct characteristics, such as atomic site occupation, anisotropic microstructure, and fewer slip systems, owing to their HCP lattice structure. Therefore, HCP metals and alloys have distinguished processing, microstructure, and properties. Several types of HCP metals and alloys, involving titanium, zirconium, magnesium, and so on, are extensively used in a variety of industrial and military sectors. Up to date, an increased requirement is still needed to improve the understanding of the relationships among processing, microstructures, and the resultant properties of HCP …


Self-Regulatory Goal Motivational Processes In Sustained New Year Resolution Pursuit And Mental Wellbeing, Joanne M. Dickson, Nicholas J. Moberly, David Preece, Alyson Dodd, Christopher D. Huntley Jan 2021

Self-Regulatory Goal Motivational Processes In Sustained New Year Resolution Pursuit And Mental Wellbeing, Joanne M. Dickson, Nicholas J. Moberly, David Preece, Alyson Dodd, Christopher D. Huntley

Research outputs 2014 to 2021

Recent research suggests people typically “give up” pursuing their New Year resolutions within the first month. The present study investigated goal features proposed to be implicated in promoting both mental wellbeing and sustained New Year resolution pursuit. Australian and UK participants (n = 182) took part in an online longitudinal study, including four timepoints over a two-month period. At baseline, participants listed the New Year resolution to which they were most committed, and completed self-report measures to assess mental wellbeing, goal flexibility and te-nacity. At the follow-up surveys, participants completed the wellbeing measure and their New Year resolution commitment, effort …


A Geospatiotemporal And Causal Inference Epidemiological Exploration Of Substance And Cannabinoid Exposure As Drivers Of Rising Us Pediatric Cancer Rates, Albert S. Reece, Gary K. Hulse Jan 2021

A Geospatiotemporal And Causal Inference Epidemiological Exploration Of Substance And Cannabinoid Exposure As Drivers Of Rising Us Pediatric Cancer Rates, Albert S. Reece, Gary K. Hulse

Research outputs 2014 to 2021

Background: Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975–2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. We investigated whether cannabis use was related spatiotemporally and causally to TPCIR. Methods: State-based age-adjusted TPCIR data was taken from the CDC Surveillance, Epidemiology and End Results cancer database 2003–2017. Drug exposure was taken from the nationally-representative National Survey of Drug Use and Health, response rate 74.1%. Drugs included were: tobacco, alcohol, cannabis, opioid analgesics and cocaine. This was supplemented by cannabinoid concentration data from the …


Hospital Staff, Volunteers’ And Patients’ Perceptions Of Barriers And Facilitators To Communication Following Stroke In An Acute And A Rehabilitation Private Hospital Ward: A Qualitative Description Study, Sarah D'Souza, Erin Godecke, Natalie Ciccone, Deborah J. Hersh, Heidi Janssen, Elizabeth Armstrong Jan 2021

Hospital Staff, Volunteers’ And Patients’ Perceptions Of Barriers And Facilitators To Communication Following Stroke In An Acute And A Rehabilitation Private Hospital Ward: A Qualitative Description Study, Sarah D'Souza, Erin Godecke, Natalie Ciccone, Deborah J. Hersh, Heidi Janssen, Elizabeth Armstrong

Research outputs 2014 to 2021

Objectives

To explore barriers and facilitators to patient communication in an acute and rehabilitation ward setting from the perspectives of hospital staff, volunteers and patients following stroke.

Design

A qualitative descriptive study as part of a larger study which aimed to develop and test a Communication Enhanced Environment model in an acute and a rehabilitation ward.

Setting

A metropolitan Australian private hospital.

Participants

Focus groups with acute and rehabilitation doctors, nurses, allied health staff and volunteers (n=51), and interviews with patients following stroke (n=7), including three with aphasia, were conducted.

Results

The key themes related to barriers and facilitators to …


Evaluation Of The Surface Defects And Dimensional Tolerances In Multi-Hole Drilling Of Aa5083, Aa6061, And Aa2024, Muhammad Aamir, Majid Tolouei Rad, Khaled Giasin, Ana Vafadar, Ugur Koklu, William Keeble Jan 2021

Evaluation Of The Surface Defects And Dimensional Tolerances In Multi-Hole Drilling Of Aa5083, Aa6061, And Aa2024, Muhammad Aamir, Majid Tolouei Rad, Khaled Giasin, Ana Vafadar, Ugur Koklu, William Keeble

Research outputs 2014 to 2021

Drilling is one of the most performed machining operations for riveting and assembly operations in many industrial sectors. The accuracy of the drilled holes and their surface finish play a vital role in the longevity and performance of the machined components, which, in turn, increase productivity. Therefore, this study investigated the effect of the multi-spindle drilling process on dimensional hole tolerances, such as hole size, circularity, cylindricity, and perpendicularity. In addition, the surface defects formed in the holes were examined using scanning electron microscopy. Three aluminium alloys, AA2024, AA6061, and AA5083, which are commonly used in the aerospace, automotive, and …


Meta-Analysis Of Genome-Wide Dna Methylation Identifies Shared Associations Across Neurodegenerative Disorders, Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kłoszewska, Bruno Vellas, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. Mccombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter Van Rheenen, Leonard H. Van Den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. Mcrae, The Alzheimer's Disease Neuroimaging Initiative, The Australian Imaging Biomarkers And Lifestyle Study Jan 2021

Meta-Analysis Of Genome-Wide Dna Methylation Identifies Shared Associations Across Neurodegenerative Disorders, Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kłoszewska, Bruno Vellas, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. Mccombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter Van Rheenen, Leonard H. Van Den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. Mcrae, The Alzheimer's Disease Neuroimaging Initiative, The Australian Imaging Biomarkers And Lifestyle Study

Research outputs 2014 to 2021

Background: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined by the combined effects of genetic variation and the environment. In this study, we aim to identify shared blood DNAm differences between controls and people with Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. Results: We use a mixed-linear model method (MOMENT) that accounts for the effect of (un)known confounders, to test for the association of each DNAm site with each …


Core Alzheimer’S Disease Cerebrospinal Fluid Biomarker Assays Are Not Affected By Aspiration Or Gravity Drip Extraction Methods, James D. Doecke, Cindy Francois, Christopher J. Fowler, Erik Stoops, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Qiao-Xin Li, Colin L. Masters, Ralph N. Martins, Victor L. Villemagne, Steven J. Collins, Hugo Marcel Vanderstichele Jan 2021

Core Alzheimer’S Disease Cerebrospinal Fluid Biomarker Assays Are Not Affected By Aspiration Or Gravity Drip Extraction Methods, James D. Doecke, Cindy Francois, Christopher J. Fowler, Erik Stoops, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Qiao-Xin Li, Colin L. Masters, Ralph N. Martins, Victor L. Villemagne, Steven J. Collins, Hugo Marcel Vanderstichele

Research outputs 2014 to 2021

Background: CSF biomarkers are well-established for routine clinical use, yet a paucity of comparative assessment exists regarding CSF extraction methods during lumbar puncture. Here, we compare in detail biomarker profiles in CSF extracted using either gravity drip or aspiration. Methods: Biomarkers for β-amyloidopathy (Aβ1–42, Aβ1–40), tauopathy (total tau), or synapse pathology (BACE1, Neurogranin Trunc-p75, α-synuclein) were assessed between gravity or aspiration extraction methods in a sub-population of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study (cognitively normal, N = 36; mild cognitive impairment, N = 8; Alzheimer’s disease, N = 6). Results: High biomarker concordance between extraction methods was seen …


Association Of Genetic Variances In Adrb1 And Ppargc1a With Two-Kilometre Running Time-Trial Performance In Australian Football League Players: A Preliminary Study, Ysabel Jacob, Ryan S. Anderton, Jodie L. Cochrane Wilkie, Brent Rogalski, Simon M. Laws, Anthony Jones, Tania Spiteri, Nicolas H. Hart Jan 2021

Association Of Genetic Variances In Adrb1 And Ppargc1a With Two-Kilometre Running Time-Trial Performance In Australian Football League Players: A Preliminary Study, Ysabel Jacob, Ryan S. Anderton, Jodie L. Cochrane Wilkie, Brent Rogalski, Simon M. Laws, Anthony Jones, Tania Spiteri, Nicolas H. Hart

Research outputs 2014 to 2021

Abstract: Genetic variants in the angiotensin-converting enzyme (ACE) (rs4343), alpha-actinin-3 (ACTN3) (rs1815739), adrenoceptor-beta-1 (ADRB1) (rs1801253), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) (rs8192678) genes have previously been associated with elite athletic performance. This study assessed the influence of polymorphisms in these candidate genes towards endurance test performance in 46 players from a single Australian Football League (AFL) team. Each player provided saliva buccal swab samples for DNA analysis and genotyping and were required to perform two independent two-kilometre running time-trials, six weeks apart. Linear mixed models were created to account for repeated measures over time and to determine whether …


Using Exercise And Nutrition To Alter Fat And Lean Mass In Men With Prostate Cancer Receiving Androgen Deprivation Therapy: A Narrative Review, Rebekah L. Wilson, Dennis R. Taaffe, Robert U. Newton, Nicolas H. Hart, Philippa Lyons-Wall, Daniel A. Galvao Jan 2021

Using Exercise And Nutrition To Alter Fat And Lean Mass In Men With Prostate Cancer Receiving Androgen Deprivation Therapy: A Narrative Review, Rebekah L. Wilson, Dennis R. Taaffe, Robert U. Newton, Nicolas H. Hart, Philippa Lyons-Wall, Daniel A. Galvao

Research outputs 2014 to 2021

Fat mass (FM) gain and lean mass (LM) loss are common side effects for patients with prostate cancer receiving androgen deprivation therapy (ADT). Excess FM has been associated with an increased risk of developing obesity-related comorbidities, exacerbating prostate cancer progression, and all-cause and cancer-specific mortality. LM is the predominant contributor to resting metabolic rate, with any loss impacting long-term weight management as well as physical function. Therefore, reducing FM and preserving LM may improve patient-reported outcomes, risk of disease progression, and ameliorate comorbidity development. In ADT-treated patients, exercise and nutrition programs can lead to improvements in quality of life and …


Flavonoid Intake And Incident Dementia In The Danish Diet, Cancer, And Health Cohort, Catherine P. Bondonno, Nicola P. Bondonno, Frederik Dalgaard, Kevin Murray, Samantha L. Gardener, Ralph N. Martins, Stephanie R. Rainey-Smith, Aedín Cassidy, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson Jan 2021

Flavonoid Intake And Incident Dementia In The Danish Diet, Cancer, And Health Cohort, Catherine P. Bondonno, Nicola P. Bondonno, Frederik Dalgaard, Kevin Murray, Samantha L. Gardener, Ralph N. Martins, Stephanie R. Rainey-Smith, Aedín Cassidy, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson

Research outputs 2014 to 2021

No abstract provided.


Population-Specific Resilience Of Halophila Ovalis Seagrass Habitat To Unseasonal Rainfall, An Extreme Climate Event In Estuaries, Chanelle L. Webster, Kieryn L. Kilminster, Marta Sánchez Alarcón, Katherine Bennett, Simone Strydom, Sian Mcnamara, Paul S. Lavery, Kathryn M. Mcmahon Jan 2021

Population-Specific Resilience Of Halophila Ovalis Seagrass Habitat To Unseasonal Rainfall, An Extreme Climate Event In Estuaries, Chanelle L. Webster, Kieryn L. Kilminster, Marta Sánchez Alarcón, Katherine Bennett, Simone Strydom, Sian Mcnamara, Paul S. Lavery, Kathryn M. Mcmahon

Research outputs 2014 to 2021

  1. Extreme climate events are predicted to alter estuarine salinity gradients exposing habitat-forming species to more frequent salinity variations. The intensity and duration of these variations, rather than the mean salinity values ecosystems are exposed to, may be more important in influencing resilience but requires further investigation.
  2. Precipitation, including the frequency, intensity and timing of occurrence, is shifting due to climate change. A global analysis on the timing of rainfall in estuarine catchments was conducted. In 80% of the case studies, the maximum daily rainfall occurred in the dry season at least once over the 40-year period and could be classified …


Predictors Of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis, The Rehabilitation And Recovery Of People With Aphasia After Stroke (Release) Collaborators Jan 2021

Predictors Of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis, The Rehabilitation And Recovery Of People With Aphasia After Stroke (Release) Collaborators

Research outputs 2014 to 2021

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all …


Exercise Medicine In The Management Of Pancreatic Cancer: A Systematic Review, Hao Luo, Daniel A. Galvão, Robert U. Newton, Pedro Lopez Da Cruz, Colin Tang, Ciaran M. Fairman, Nigel Spry, Dennis R. Taaffe Jan 2021

Exercise Medicine In The Management Of Pancreatic Cancer: A Systematic Review, Hao Luo, Daniel A. Galvão, Robert U. Newton, Pedro Lopez Da Cruz, Colin Tang, Ciaran M. Fairman, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. The review protocol was registered in PROSPERO: CRD42020154684. Seven trials described in 9 publications were included consisting of 201 patients with early-stage and …


Are We Heading For Disaster? The Problem With Resilience In Disaster Management And Recovery, Zachary Horn Jan 2021

Are We Heading For Disaster? The Problem With Resilience In Disaster Management And Recovery, Zachary Horn

Research outputs 2014 to 2021

Resilience is often construed as armour that protects individuals from stressors and harm, or a trait that allows people to ‘bounce back’ despite adversities and stressors. Although not fundamentally incorrect, these notions do not capture the true purpose, scope or power of resilience, particularly in the disaster context.


The Effect Of Cryogenic Machining Of S2 Glass Fibre Composite On The Hole Form And Dimensional Tolerances, Ugur Koklu, Sezer Morkavuk, Carol Featherston, Malik Haddad, David Sanders, Muhammad Aamir, Danil Yu Pimenov, Khaled Giasin Jan 2021

The Effect Of Cryogenic Machining Of S2 Glass Fibre Composite On The Hole Form And Dimensional Tolerances, Ugur Koklu, Sezer Morkavuk, Carol Featherston, Malik Haddad, David Sanders, Muhammad Aamir, Danil Yu Pimenov, Khaled Giasin

Research outputs 2014 to 2021

S2 glass fibre reinforced epoxy composites are widely used in aeronautical applications owing to their excellent strength to weight ratio. Drilling glass fibres can be cumbersome due to their abrasive nature and poor thermal conductivity. Moreover, the use of conventional coolants is not desirable due to contamination and additional costs for cleaning the machine part. An alternative is to use environmentally friendly coolants such as liquid nitrogen (LN2) which have been previously employed in machining metals and composites. The current study investigates the effect of drilling S2 glass fibre composite in a bath of LN2. The study aims to evaluate …


Effects Of Variations In Resistance Training Frequency On Strength Development In Well-Trained Populations And Implications For In-Season Athlete Training: A Systematic Review And Meta-Analysis, Matthew Cuthbert, G. Gregory Haff, Shawn M. Arent, Nicholas Ripley, John J. Mcmahon, Martin Evans, Paul Comfort Jan 2021

Effects Of Variations In Resistance Training Frequency On Strength Development In Well-Trained Populations And Implications For In-Season Athlete Training: A Systematic Review And Meta-Analysis, Matthew Cuthbert, G. Gregory Haff, Shawn M. Arent, Nicholas Ripley, John J. Mcmahon, Martin Evans, Paul Comfort

Research outputs 2014 to 2021

Background: In-season competition and tournaments for team sports can be both long and congested, with some sports competing up to three times per week. During these periods of time, athletes need to prepare technically, tactically and physically for the next fixture and the short duration between fixtures means that, in some cases, physical preparation ceases, or training focus moves to recovery as opposed to progressing adaptations. Objective: The aim of this review was to investigate the effect of training frequency on muscular strength to determine if a potential method to accommodate in-season resistance training, during busy training schedules, could be …