Digital Commons Network^™

Heritability Enrichment Of Immunoglobulin G N-Glycosylation In Specific Tissues, Xingang Li, Hao Wang, Yahong Zhu, Weijie Cao, Song Manshu, Youxin Wang, Haifeng Hou, Minglin Lang, Xiuhua Guo, Xuerui Tan, Jingdong J. Han, Wei Wang

Research outputs 2014 to 2021

Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain. Leveraging data from GWAS summary statistics for 8,090 Europeans, and large-scale expression quantitative trait loci (eQTL) data from the genotype-tissue expression of 53 types of tissues (GTEx v7), we derived a linkage disequilibrium score for the specific expression of genes (LDSC-SEG) and conducted a transcriptome-wide association study (TWAS). We identified 55 gene associations whose predicted levels of expression were significantly associated with IgG N-glycosylation in 14 tissues. Three working scenarios, i.e., tissue-specific, …

The Support Person's Preferences And Perspectives Of Physical Activity Programs For Older Adults With Cognitive Impairment, Terence W. H. Chong, Emily You, Kathryn A. Ellis, Kay L. Cox, Karra D. Harrington, Stephanie R. Rainey-Smith, David Ames, Nicola T. Lautenschlager, Aibl Research Group

Research outputs 2014 to 2021

Objectives: Physical activity (PA) is beneficial for older adults' cognition. There is limited research investigating perspectives of support persons (SPs) of next-of-kins (NOKs) with cognitive impairment. This exploratory study aimed to investigate perspectives of SPs of older adults with Alzheimer's Dementia (AD) or Mild Cognitive Impairment (MCI). Methods: A telephone survey of 213 SPs of NOKs from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) was undertaken to quantitatively assess SPs' beliefs and knowledge about PA benefits, current PA level of their NOK, and PA program preferences. The contribution of age, gender, diagnosis and mental health symptoms …

Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar

Research outputs 2014 to 2021

Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were …

Professional Fishing Industry Fatality, Incident And Injury Data Project, Greg Penney, Bill Byrne, Marcus Cattani

Research outputs 2014 to 2021

Analysis of occupational injuries and fatalities within the wild-catch Australian Commercial Fishing Industry (ACFI) is complicated by fishing crew (masters, deckhands etc) classification as workers being dependent upon the applicable occupational health and safety, and worker’s compensation legislation of the relevant State or Territory. While fishing vessels are considered a workplace consistently across all State’s and Territories Work Health and Safety (WHS) / Occupational Health and Safety (OHS) jurisdiction’s legislation, the people who work on them may not be deemed to be workers or employees as per state and territory workers compensation legislation. The exclusion of fishing crew as workers …

The Need For Aerospace Structural Health Monitoring: A Review Of Aircraft Fatigue Accidents, Luke Pollock, Ayah Khalid Abdelwahab, John Murray, Graham Wild

Research outputs 2014 to 2021

Aircraft accidents involving catastrophic fatigue failure have the potential for significant loss of life. The aim of this research was to investigate trends in aircraft fatigue failure accidents to inform aerospace Structural Health Monitoring (SHM) system Research and Development (R&D). The research involved collecting 139 aircraft fatigue failure accident reports from the Aviation Safety Network database, which were coded using a directed content analysis. The trends and features of the categorical data were then explored using an ex-post facto study. The results showed that fatigue failure accidents have increased at a rate of (3.4 ± 0.6)×10-2 per year since the …

Short-Term Capital Flows, Exchange Are Expectation And Currency Internationalization: Evidence From China, Mingming Li, Fengming Qin, Zhaoyong Zhang

Research outputs 2014 to 2021

This paper intended to employ a portfolio approach to assess the effect of exchange rate expectation on Chinese RMB internationalization and empirically test the interactive effects among short-term capital flows, RMB appreciation expectation and the internationalization process using a VAR model with monthly data ranging from February 2004 to December 2020. The results suggest that RMB exchange rate appreciation could lead to an increase in the foreign demand for RMB and RMB denominated assets, while RMB internationalization would attract more short-term capital inflow due to the reduced transaction costs. The empirical evidence from the VAR model estimation confirms the finding …

Segregation Analysis Of Genotyped And Family-Phased, Long Range Mhc Classical Class I And Class Ii Haplotypes In 5 Families With Type 1 Diabetes Proband In The United Arab Emirates, Guan K. Tay, Halima Al Naqbi, Aurélie Mawart, Zahrah Baalfaqih, Anoud Almaazmi, Asma Deeb, Habiba Alsafar

Research outputs 2014 to 2021

The classical Human Leucocyte Antigen (HLA) class II haplotypes of the Major Histocompatibility Complex (MHC) that are associated with type 1 diabetes (T1D) were identified in five families from the United Arab Emirates (UAE). Segregation analyses were performed on these 5 families with the disease, 3 with one child and 2 with 2 children diagnosed with T1D. Three HLA-DR4 haplotypes were identified: HLA- DRB1∗04:01:01-DQB1∗03:02:01:01; HLA- DRB1∗04:02:01- DQB1∗03:02:01; and HLA -DRB1∗04:05:01-DQB1∗02:02:01:02. All have previously been identified to be associated with T1D in studies of the Arabian population. In the 10 parents from the 5 families, 9 had at least one HLA-DR4 …

Designing Call To Action: Users' Perception Of Different Charateristics, Thomas Mejtoft, Jonathan Hedlund, Helen Cripps, Ulrik Söderström, Ole Norberg

Research outputs 2014 to 2021

This paper aims to provide guidance when designing a call to action in a digital system with the purpose to create an intended feeling and user engagement. The paper is based on a test of four different simple call to action constructions. The users clearly prefer constructions that have a high explainability and feels intuitive. Hence, the design should have a high level of transparency and show the user straight away what it demands from the user and what the result of the action is. Furthermore, the design should have a high usability to make it clear how to use …

Into The Breech: A Multi-National E-Delphi Study Exploring Breech Presentation And Birth Care, Sara Morris

Research outputs 2014 to 2021

Aim: To establish consensus regarding care of women with a breech presenting fetus through the exploration of participants’ knowledge, experiences and opinions regarding breech presentation and care.

Design: Three round Delphi e-survey

Setting: Multi-national

Participants: A panel of fifteen midwives, four obstetricians and one academic with an interest in breech care and birth.

Methods: The initial survey comprised of open-ended questions. Answers were coded and integrated to form statements presented to participants over 3 sections in the second round due to the abundance of information collected from first round responses. Consensus was deemed reached if 70% or more of participants …

Physicochemical Characterisation Of Zirconia Nanoparticles Based Sodium Alginate Polymer Suspension For Enhanced Oil Recovery, Udit S. Mohanty, Faisal Ur Rahman Awan, Muhammad Ali, Adnan Aftab, Alireza Keshavarz, Sefan Iglauer

Research outputs 2014 to 2021

Biopolymers have been employed in enhanced oil recovery (EOR) due to their high viscosity and significant effects on waterflooding performance. Sodium alginate (NaAlg) is an excellent biopolymer that is extracted primarily from brown algae. It has been used in the biotechnology industry as a thickening agent, colloidal stabilizer, and oil recovery application. In the present study, a series of sodium alginate/zirconium oxide nanoparticle suspensions were prepared via solution mixing, and the effect of nanoparticle content, polymer concentration, temperature, salinity was investigated on the rheological behavior using a concentric cylinder dynamic rheometer. The rheology results revealed that the lower concentration of …

Climate Change, Activism, And Supporting The Mental Health Of Children And Young People: Perspectives From Western Australia, Naomi J. Godden, Brad M. Farrant, Jaime Yallup Farrant, Emma Heyink, Eva Carot Collins, Bella Burgemeister, Mena Tabeshfar, Jason Barrow, Mara West, Jasmine Kieft, Mason Rothwell, Zoe Leviston, Susan Bailey, Mindy Blaise, Trudi Cooper

Research outputs 2014 to 2021

The climate crisis has detrimental impacts on the mental health and wellbeing of children and young people. Psychological effects include feelings of fear, overwhelm, worry, distress, hopelessness and anger; PTSD; depression; anxiety; phobias; panic disorder; sleep disturbances; attachment disorders; learning difficulties; substance abuse; shock and trauma symptoms; adjustment problems; behavioural problems; and, suicidal thinking. First Nations' children and young people are particularly at risk due to loss of place, identity, culture, land and customs informed by kinship relationships with the Earth; while sustainable land use practices and connection to Country and community can enhance climate resilience. In Western Australia (WA), …

Midwives’ Strategies For Coping With Barriers To Providing Quality Maternal And Neonatal Care: A Glaserian Grounded Theory Study, Yakubu Ismaila, Sara Bayes, Sadie Geraghty

Research outputs 2014 to 2021

Background: Midwives face direct and indirect barriers in their workplaces that have negative consequences on their ability to provide quality care to women and neonates, however, they still carry on with their duties. This study aimed at investigating the coping strategies that Ghanaian midwives adopt to be able to complete their work. Methods: Glaserian Grounded theory was used in this study. Data were collected through non-participant observations and semi-structured interviews. The study participants included 29 midwives who worked in labour/birthing environments and a pharmacist, a social worker, a national Health Insurance Scheme manager and a health services manager. Findings: The …

Evaluating Match Running Performance In Elite Australian Football: A Narrative Review, Christopher Wing, Nicolas H. Hart, Fadi Ma’Ayah, Kazunori Nosaka

Research outputs 2014 to 2021

During Australian football (AF) matches, players are subjected to high running loads, which are intermittent in nature. There is a growing body of research that highlights factors which can both positively and negatively affect this match running performance (e.g., the total distance travelled by a player during match-play). In order to appropriately evaluate these factors, a thorough search of MEDLINE, SportDiscus and Web of Science databases was performed, with a total of 17 manuscripts included within the final evaluation. The main findings from this review highlighted that match running performance is increased amongst those playing in midfield and half back/forward …

Investigating Auditory Electrophysiological Measures Of Participants With Mild Cognitive Impairment And Alzheimer's Disease: A Systematic Review And Meta-Analysis Of Event-Related Potential Studies, Hadeel Y. Tarawneh, Wilhelmina H. A. M. Mulders, Hamid R. Sohrabi, Ralph N. Martins, Dona M. P. Jayakody

Research outputs 2014 to 2021

Background: Objectively measuring auditory functions has been proposed as an avenue in differentiating normal age-related cognitive dysfunction from Alzheimer's disease (AD) and its prodromal states. Previous research has suggested auditory event-related potentials (AERPs) to be non-invasive, cost-effective, and efficient biomarkers for the diagnosis of AD. Objective: The objective of this paper is to review the published literature on AERPs measures in older adults diagnosed with AD and those at higher risk of developing AD, i.e., mild cognitive impairment (MCI) and subjective cognitive decline. Methods: The search was performed on six major electronic databases (Ovid MEDLINE, OVID EMBASE, PsycINFO, PubMed, Scopus, …

The Effect Of Exercise Compliance On Risk Reduction For Hamstring Strain Injury: A Systematic Review And Meta-Analyses, Nicholas J. Ripley, Matthew Cuthbert, Steven Ross, Paul Comfort, John J. Mcmahon

Research outputs 2014 to 2021

Eccentric strength training can reduce the risk of hamstring strain injury (HSI) occurrence; however, its implementation can be impacted by athlete compliance and prescription. The aim of this review was to investigate the effects of intervention compliance, consistency and modality, on the prevention of HSIs among athletes. A literature search was conducted. 868 studies were identified prior to the application of the exclusion criteria which resulted in 13 studies identified. Random effects models were used to produce log odds ratios and 95% confidence intervals. Very high ( > 75.1%), moderate-high (50.1–75%), low-moderate (25.1–50%) and very low ( < 25%) and < 1-, 1.01–3.00-, > 3.01-weeks/session were used as …

The Intra-And Inter-Rater Reliability Of A Hip Rotation Range-Of-Motion Measurement Using A Smartphone Application In Academy Football (Soccer) Players, Paul Spork, James O’Brien, Morris Sepoetro, Maximilian Plachel, Thomas Stöggl

Research outputs 2014 to 2021

The clinical assessment of hip rotation range-of-motion (ROM) is important for managing hip and groin injuries in footballers. Previously published reliability studies on hip ROM have employed protocols that are difficult to replicate under everyday clinical conditions. This single trial, intra-and inter-rater reliability study included 41 male academy football (soccer) players, aged 14–15 years, from one European football academy. Passive hip internal rotation (IR) and external rotation (ER) ROM were measured in supine with hip and knee flexed to 90◦ . The ROM was determined using a smartphone application, with the smartphone attached to the lower leg. The tests were …

Exploring The Implementation Of An Intervention For A Pupil With Mathematical Learning Difficulties: A Case Study, Kin Eng Chin, Sai Hoe Fu

Research outputs 2014 to 2021

This study presents a single case study of how a remedial mathematics teacher incorporated an instructional intervention into her teaching practices in order to teach counting to a pupil with mathematical learning difficulties. This new theory-driven intervention was developed by the authors of this study. Dyscalculia is a term which refers to a wide range of mathematical learning difficulties or disabilities. Dyscalculic pupils have a specific mathematics learning disorder with a core deficit in representing and processing of numerosity. They might not be able to recognise numerical quantities, performing counting and so on. Early supports such as interventions have a …

Common Worlding Pedagogies: Opening Up To Learning With Worlds, Affrica Taylor, Tatiana Zakharova, Maureen Cullen

Research outputs 2014 to 2021

Common worlding is a collective pedagogical approach. It is also a deliberate move to open up education to worlds beyond narrow human preoccupations and concerns and beyond its standard framing as an exclusively social practice. In this article, we identify some of the guiding principles that underpin this approach and explain how they work out in practice. We do so by offering a selection of illustrative vignettes drawn from the Walking with Wildlife in Wild Weather Times early childhood research project in Canberra, Australia, and from the Witnessing the Ruins of Progress early childhood research collaboratory in Ontario, Canada.

Customer Value Creation For The Emerging Market Middle Class: Perspectives From Case Studies In India, Rifat Sharmelly, Anton Klarin

Research outputs 2014 to 2021

This paper examines the customer value creation framework and discusses the design of the key elements for product development in emerging markets. A scientometric/bibliometric scoping literature review identifies a clear gap in the current research in studying prerequisites for customer value creation in emerging market contexts. Observing experiences of Daikin and Renault in the context of India, the purpose of this paper is to identify value creation strategic choices following which comprehensive customer value offerings in products and services can be successfully created by firms across the four facets of the framework in emerging markets. Value creation strategies include having …

Does Warfarin Or Rivaroxaban At Low Anticoagulation Intensity Provide A Survival Benefit To Asian Patients With Atrial Fibrillation?, Dong Lin, Yequn Chen, Jian Yong, Shiwan Wu, Yan Zhou, Weiping Li, Xuerui Tan, Ruisheng Liu

Research outputs 2014 to 2021

Background: Low-dose rivaroxaban and low-intensity warfarin are widely used in Asia for patients with atrial fibrillation (AF). However, in Asians, it is unclear whether low-dose rivaroxaban and low-intensity warfarin can improve the prognosis of AF. In this study, we investigate the survival benefits of low-dose rivaroxaban and low-intensity warfarin in Asian patients with AF in clinical practice. Methods: This cohort study used medical records in a single tertiary hospital in China, between 2019 and 2020, to identify patients with AF who used rivaroxaban or warfarin, or had no anticoagulant therapy. Follow-ups were performed through telephone contact or medical record review. …

The State Of Micro-Credentials Implementation And Practice In Australasian Higher Education, Ratna Selvaratnam, Michael Sankey

Research outputs 2014 to 2021

Micro-credentialing is rapidly growing globally as learning that is both life-long and life-wide and this has only accelerated due to COVID-19. To understand what this means for higher education, The Australasian Council on Open, Distance and eLearning has conducted two surveys on the implementation and practice of micro-credentialing in the Australasian sector. With the surveys conducted a year apart, before and after the pandemic, significant changes are noted in the delivery of learning. The results show an increased interest and intention in rolling out micro-credentials, as evidenced, particularly, in work undertaken at the policy level. However, in relation to actual …

Fecal Sample Collection Methods And Time Of Day Impact Microbiome Composition And Short Chain Fatty Acid Concentrations, Jacquelyn Jones, Stacey N. Reinke, Alishum Ali, Debra J. Palmer, Claus T. Christophersen

Research outputs 2014 to 2021

Associations between the human gut microbiome and health outcomes continues to be of great interest, although fecal sample collection methods which impact microbiome studies are sometimes neglected. Here, we expand on previous work in sample optimization, to promote high quality microbiome data. To compare fecal sample collection methods, amplicons from the bacterial 16S rRNA gene (V4) and fungal (ITS2) region, as well as short chain fatty acid (SCFA) concentrations were determined in fecal material over three timepoints. We demonstrated that spot sampling of stool results in variable detection of some microbial members, and inconsistent levels of SCFA; therefore, sample homogenization …

Insights Into The Cultured Bacterial Fraction Of Corals, Michael Sweet, Helena Villela, Tina Keller-Costa, Rodrigo Costa, Stefano Romano, David G. Bourne, Anny Cárdenas, Megan J. Huggett, Allison H. Kerwin, Felicity Kuek, Mónica Medina, Julie L. Meyer, Moritz Müller, F. Joseph Pollock, Michael S. Rappé, Mathieu Sere, Koty H. Sharp, Christian R. Voolstra, Nathan Zaccardi, Maren Ziegler, Raquel Peixoto

Research outputs 2014 to 2021

Bacteria associated with coral hosts are diverse and abundant, with recent studies suggesting involvement of these symbionts in host resilience to anthropogenic stress. Despite their putative importance, the work dedicated to culturing coral-associated bacteria has received little attention. Combining published and unpublished data, here we report a comprehensive overview of the diversity and function of culturable bacteria isolated from corals originating from tropical, temperate, and cold-water habitats. A total of 3,055 isolates from 52 studies were considered by our metasurvey. Of these, 1,045 had full-length 16S rRNA gene sequences, spanning 138 formally described and 12 putatively novel bacterial genera across …

Critical Role Of General Practitioners In Preventing Readmission Following Emergency Department Alcohol Screening And Brief Intervention Management Of Alcohol-Related Problems, Simon Hazeldine, Imogen Davies, Robert J. Tait, John K. Olynyk

Research outputs 2014 to 2021

Introduction/Objectives: Alcohol screening and brief intervention (ASBI) strategies are useful in general practice (GP) but their effectiveness in the emergency department (ED) is unclear. We evaluated the effect of ED-based ASBI on re-admissions. Methods: 453 ED subjects exceeding the threshold score on the three-item Alcohol Use Disorders Identification Test-Consumption (females 3+: males 4+) were randomized. We conducted telephone follow-up at 1 and 3 months and recorded hospital events 6 months pre- and post-enrolment. Results: Median weekly alcohol use was 20 standard drinks (interquartile range (IQR) 9-45) on enrolment. After 3 months, 247 (55%) were able to be re-interviewed. Median alcohol …

Association Between High-Density Lipoprotein Cholesterol And Type 2 Diabetes Mellitus Among Chinese: The Beijing Longitudinal Study Of Aging, Xue Cao, Zhe Tang, Jie Zhang, Haibin Li, Manjot Singh, Fei Sun, Xiaochun Li, Changwei Li, Youxin Wang, Xiuhua Guo, Deqiang Zheng

Research outputs 2014 to 2021

Background: Some previous studies on different populations have yielded inconsistent findings with respect to the relationship between levels of high-density lipoprotein cholesterol (HDL-C) and future type 2 diabetes mellitus (T2DM) incidence. This study was designed to gain further insight into this relationship through a cohort study with a 25-year follow-up duration. Methods: In total, 1462 individuals that were 55 years of age or older and were free of T2DM at baseline were enrolled in the present study. T2DM incidence among this study population was detected through self-reported diagnoses or the concentration of fasting plasma glucose. The data were derived from …

Kelp-Associated Microbes Facilitate Spatial Subsidy In A Detrital-Based Food Web In A Shoreline Ecosystem, Charu Lata Singh, Megan J. Huggett, Paul S. Lavery, Christin Säwström, Glenn A. Hyndes

Research outputs 2014 to 2021

Microbes are ubiquitous but our knowledge of their effects on consumers is limited in benthic marine systems. Shorelines often form hotspots of microbial and detritivore activity due to the large amounts of detrital macrophytes that are exported from other coastal ecosystems, such as kelp forests, and accumulate in these systems. Shoreline ecosystems therefore provide a useful model system to examine microbial-detritivore interactions. We experimentally test whether bacteria in the biofilm of kelp provide a bottom-up influence on growth and reproductive output of detritivores in shorelines where detrital kelp accumulates, by manipulating the bacterial abundances on kelp (Ecklonia radiata). The growth …

Editorial: Covid-19, Corporate Governance, Sustainability, And The Post-Neoliberal World, Marie Dela Rama, Julie Crews

Research outputs 2014 to 2021

Welcome to this special issue of Corporate Governance and Sustainability Review focusing on the impact of thecoronavirus (COVID-19) on societies and economies worldwide. The five papers in this special issue reflect the initial impact of the COVID-19 pandemic,in its first year,on corporate governance and sustainability. What is common throughout these papers is how the pandemic has created disequilibria for many organisations. The question continues to be posed as to the new forms of organising and managing as the world reorientates or pivots in a pandemic and post-pandemic world.

The Role Of Leadership In Aviation Safety And Aircraft Airworthiness, Ayiei Ayiei, Luke Pollock, Fatima Najeeb Khan, John Murray, Glenn Baxter, Graham Wild

Research outputs 2014 to 2021

Ensuring aircraft are technically safe to operate is the realm of airworthiness, literally worthy of being in the air. This is achieved not only with technological tools and techniques, or with just personnel and manpower, it is guided and supervised by managers and leaders. As such, the objective of this paper is to understand the role leadership plays in maintaining aviation safety and aircraft airworthiness. To this end, a case study of the Hawker Sidley Nimrod XV230 accident that occured on September 2, 2006 near Kandahar in Afghanistan, was utilized. The study concluded that leadership is a key aspect, specifically …

Application Of Mass Spectrometry-Based Proteomics To Barley Research, Mahya Bahmani, Clare E. O'Lone, Angéla Juhász, Mitchell Nye-Wood, Hugh Dunn, Ian B. Edwards, Michelle L. Colgrave

Research outputs 2014 to 2021

Barley (Hordeum vulgare) is the fourth most cultivated crop in the world in terms of production volume, and it is also the most important raw material of the malting and brewing industries. Barley belongs to the grass (Poaceae) family and plays an important role in food security and food safety for both humans and livestock. With the global population set to reach 9.7 billion by 2050, but with less available and/or suitable land for agriculture, the use of biotechnology tools in breeding programs are of considerable importance in the quest to meet the growing food gap. Proteomics as a member …

Genetic And Ecological Consequences Of Recent Habitat Fragmentation In A Narrow Endemic Plant Species Within An Urban Context, Nicola Delnevo, Andrea Piotti, Michele Carbognani, Eddie J. Van Etten, William D. Stock, David L. Field, Margaret Byrne

Research outputs 2014 to 2021

Understanding the timescales that shape spatial genetic structure is pivotal to ascertain the impact of habitat fragmentation on the genetic diversity and reproductive viability of long-lived plant populations. Combining genetic and ecological information with current and past fragmentation conditions allows the identification of the main drivers important in shaping population structure and declines in reproduction, which is crucial for informing conservation strategies. Using historic aerial photographs, we defined the past fragmentation conditions for the shrub Conospermum undulatum, a species now completely embedded in an urban area. We explored the impact of current and past conditions on its genetic layout …