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A New Molecular Approach To The Diagnosis Of Small Ruminant Morbillivirus Withevagreen Based Assay, Mustafa Emi̇n Öz, Emrah Torlak, Oğuzhan Avci, Müge Doğan, Ali̇ Tevfi̇k Uncu

Turkish Journal of Veterinary & Animal Sciences

The present work describes a new method that is anticipated to contribute to the global control and eradication strategies of small ruminant morbillivirus (SRMV), which negatively affects sheep and goat breeding in many countries where outbreaks emerge. Described assay was developed to detect SRMV by targeting the fusion glycoprotein gene. In the study, the EvaGreen based real-time RT-PCR method is compared with real-time RT-PCR based on TaqMan probe, which is recommended as the diagnostic test by World Organisation for Animal Health (OIE). Detection limit, normalized fluorescence values, and sensitivity of the methods were evaluated in the analysis. The lowest limit …

Ruminal Kinetics Of Carbohydrates, Gas Production And Bromatology Of Sugarcane Silagewith High Levels Of Sodium Benzoate, Celso Heinzen Junior, Odimári Pricila Prado Calixto, Egon Henrique Horst, Leonardo Trolegi, Fernando Luiz Massaro Junior, Ivone Yurika Mizubuti, Mikael Neumann, Valter Harry Bumbieris Junior

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to evaluate the chemical composition, ruminal kinetics, gas production and aerobic stability of sugarcane silage added with increasing levels of sodium benzoate up to 1% of the natural matter. After harvesting, the sugarcane was chopped and placed in experimental polyethylene silos for storage for 30 days. An increasing concentration of sodium benzoate in the silage promoted a linear decrease in the crude protein content, varying from 2.79% to 2.51%. The addition of sodium benzoate reduced the fiber concentration of the silage (P = 0.0015) and increased gas production of the fibrous and nonfibrous carbohydrates …

Ocular Ultrasonography And Echobiometry In Sheep, Hakim Athar, Jalal Udin Parrah, Nida Handoo, Abdul Qayoom Mir, Mehraj Udin Dar, Beenish Qureshi

Turkish Journal of Veterinary & Animal Sciences

Ocular sonography and echobiometry was performed in local nondescript sheep (N = 36) of different age group and in adult corriedale (N = 60), crossbred Fec B (N = 48), and Poll Dorset cross breed sheep (N = 48). Cornea, anterior, posterior lens capsule, and retinal rim appeared hyperechoic whereas aqueous, vitreous humor, and nucleus of lens were anechoic. Significant increase (P < 0.05) in all the echobiometric measurement of the ocular distance except central corneal thickness and retinal rim thickness was recorded in the older animals (2 year old) compared to values recorded in animals at one month of age in local nondescript sheep. Significant differences (P < 0.05) in few recorded ocular biometric measurements were also noticed among different sheep breeds. However, the difference in the various ocular biometric measurements between the right and left eyes was nonsignificant. The results of this study provide the base line information regarding the ocular echobiometry in sheep that are relevant to comparative ocular anatomy and can be useful for ultrasonographic evaluation of different ocular affections in sheep.

Dried Tomato Pomace In Rabbit Nutrition: Effects On Carcass Characteristics And Meat Quality, Nouha Grioui, Hager Boukhris, Chokri Damergi, Wafa Hajji, Hamadi Riahi, Manef Abderrabba, Taha Najar, Mondher Mejri

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to assess the effect of dried tomato pomace (DTP) feeding on the carcass characteristics and the quality of the meat of growing rabbits. For this purpose, 54 weaned rabbits (40 days old) were divided into three equal groups and fed isoproteic and isoenergetic diets. The first group was the control group (CON), while the other two groups were fed 10 (DTP-10), and 20 (DTP-20) percent DTP for 6 weeks. Eighty-three-day-old rabbits were slaughtered then, the carcass characteristics, mechanical and sensorial tenderness of the meat were determined. Rabbits fed with DTP-10 had the highest final weight at …

Effects Of Leptin And Thyroglobulin Gene Polymorphisms On Beef Quality In Holsteinbreed Bulls In Turkey, Süleyman Kök, Güldan Vapur

Turkish Journal of Veterinary & Animal Sciences

The relationship between three single-nucleotide polymorphisms (SNP) markers and the beef quality of Turkish Holstein bulls (THB) was investigated. The markers in leptin (LEP) gene (E2JW and E2FB) and thyroglobulin (TG) gene (C422T) were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in one hundred THB. Texture, pH, and marbling score (MS) are three of the most dominating determinants of meat quality. In THB, the relationship between 3 SNPs and beef quality characteristics of musculus longissimus dorsi (MLD) was investigated. The mean pH value of the raw beef samples with the TG G422T CC genotype was 5.33 ± 0.30 …

Effects Of Honeybee (Apis Mellifera) Venom On Redox Balance, Biochemical Andhematological Profile In Diabetic Rats: A Preliminary Study, Bariş Denk, Abdurrahman Fati̇h Fi̇dan

Turkish Journal of Veterinary & Animal Sciences

The treatment of diseases with honeybee venom (apitoxin) is a branch of apitherapy, which has yet to find substantial scientific support. In this present study, we used apitoxin to investigate its effects on diabetes mellitus (DM) in rats. The use of apitoxin injection on single-dose streptozotocin (STZ)-treated rat model was selected, and the study took 28 days. Fasting blood glucose (FBG) was measured weekly. Biochemical and hematological parameters, oxidative stress markers, and insulin levels were measured from the blood samples provided on the last day of the study, and the DNA damage marker (8-OHdG) was measured from urine samples. We …

Carnitine Concentrations In Healthy And Septicaemia Suspected Neonatal Calves And Itsrelation To Passive Immunty, Erhan Gökçe, Mahmut Sözmen, Canan Gülmez, Kadi̇r Bozukluhan, Gürbüz Gökce, Emi̇ne Ataki̇şi̇, Mehmet Çi̇ti̇l, Hi̇dayet Meti̇n Erdoğan

Turkish Journal of Veterinary & Animal Sciences

This study was designed to determine carnitine concentrations in newborn calves with suspected septicaemia, healthy calves, and colostrum samples as well as to detect alterations in blood carnitine concentrations after colostrum intake. Carnitine concentrations were detected in both neonatal calves with suspected septicaemia (n = 195) and healthy calves (n =10) as well as in colostrum/milk samples from their dams (n = 20). The mean carnitine concentration on the 2nd day after colostrum intake (32.61 μmol/L) was significantly higher than that measured before colostrum intake (17.61 μmol/L) (P < 0.05). The striking result was significantly lower mean carnitine concentration detected in calves with suspected septicaemia (17.11 μmol/L), compared to healthy calves (24.92 μmol/L) (P < 0.001). Apart from a sudden increase on day 7, no significant alteration was observed in colostrum/milk carnitine concentrations throughout the postpartum period. The results indicated that colostrum contained carnitine, which passed into the bloodstream of the calf by passive colostral transfer, and that a dramatic reduction in blood carnitine concentrations of calves with suspected septicaemia existed. The results might be of help in dealing with septicaemia suspected neonatal calves through both measurement of blood carnitine and, in response, to supplement such cases with carnitine.

Isolation And Identification Of Clostridium Difficile From Cases Of Diarrhea In Young Farmanimals, And The Determination Of Antimicrobial Susceptibility, Edi̇z Kağan Özgen, Murat Yildirim

Turkish Journal of Veterinary & Animal Sciences

Clostridium difficile was isolated for the first time in 1935 from fecal samples of infants, although it was not until 1978 that its pathogenicity started to be considered, when it was shown to cause antibiotic-associated diarrhea and pseudomembranous colitis. In this study, it was aimed to determine the virulence and antibiotic resistance profiles of C. dificile in young ruminants with diarrhea and chickens fed on the farm. A total of 200 fecal samples (50 from calves, 50 from lambs and 50 from kid goats with neonatal diarrhea, as well as 50 cloacal swab samples taken from chickens) were taken and …

Rediscovery Of Pearly Tree Frog, Nyctixalus Margaritifer Boulenger, 1882 (Amphibia: Rhacophoridae) From Mt. Wilis After 135 Years, Bagus Priambodo, Richo Firmansyah, Dicky Candra Pranata, Afina Nur Aninnas, Muhamad Azmi Dwi Susanto, Fajar Dwi Nur Aji, Tri Wahyu Widodo, Gunawan Gunawan, Danafia Permana, Faisal Yanuar Adiba, Yuri Ristanto, Muhamad Prayogi Erfanda, Ahmad Muammar Kadafi

Turkish Journal of Zoology

For more than a century, pearly tree frog from its type locality (East Indies; Java; Mt. Wilis) are undiscovered. Current studies about the distribution of Nyctixalus margaritifer are reported as known only from West Java and Central Java. In this paper, we collected one individual of pearly tree frog, N. margaritifer in the Western part of Mt. Wilis, which belongs to Gunung Sigogor Nature Reserve, Ponorogo, East Java. This is the third specimen, which is discovered from the Mt. Wilis after the lost holotype in 1882 and the neotype in 1885. Poorly known on its ecology and its habitat preferences …

Determination Of Quality Of Working Life Of Private Veterinarians: Validity And Reliabilitystudy, Gökhan Aslim, Mustafa Agah Teki̇ndal, Aşkin Yaşar

Turkish Journal of Veterinary & Animal Sciences

With this study, it was aimed to determine the factors affecting the quality of working life of private veterinarians. In addition, it was aimed to develop a scale (Quality of Working Life Scale) that enables the evaluation of quality of working life of private veterinarians. The study included 367 people who work as private veterinarians in Turkey. For the structure validity, Cronbach alpha (α) coefficient was used for reliability analysis. Factor analysis was used for validity analysis. As a result of the data obtained from the study, it is stated that the "Quality of Working Life Scal" is reliable and …

Analysis Of Some Heavy Metals (Cd And Pb) In The Şanlıurfa Province Using Feral Pigeonblood Samples, Özlem Ütme, Füsun Temamoğullari

Turkish Journal of Veterinary & Animal Sciences

Birds serve as good biomonitors in determining environmental pollution. As for indicators of environmental pollution, we detected blood heavy metal levels in 32 female and 32 male local Feral pigeons in the central districts of Şanlıurfa, located in southeastern Turkey, in one month of each season. The samples were analyzed by coupled plasma-mass spectrometry. Lead (Pb) levels were measured as 233.1 ± 25.7 μg/kg for Haliliye, 101.2 ± 29.7 μg/kg for Karaköprü, 81.3 ± 22.7 μg/kg for Eyyübiye, and 48.1 ± 27.1 μg/ kg for Suruç, whereas cadmium (Cd) levels were measured as 30.6 ± 12.6 μg/kg for Haliliye, 35.7 …

The Determination Some Biological Parameters Of Phenacoccus Madeirensis Green (Hemiptera: Pseudococcidae)) On Vegetable Plants, Mustafa Gökhan Bi̇lgi̇n, Asi̇me Fi̇li̇z Çalişkan Keçe, Mehmet Ri̇fat Ulusoy

Turkish Journal of Zoology

This study has been conducted to determine some biological parameters of the Phenacoccus madeirensis Green (Hemiptera: Pseudococcidae) on four vegetable plants (7 different varieties); tomato (Hazera and Torry) ( Solanum lycopersicum L.), eggplant (Adana Topağı and Anamur) ( Solanum melongena L.), pepper (Safran and Zafer) ( Capsicum annuum L.), and Pepino (Minski) ( Solanum muricatum L.). Experiments were carried out in climate cabinets at 25 ± 2 °C, 60 ± 10% R.H., and 16L: 8D) in Plant Protection Department Nedim UYGUN Biological Control Laboratory of Agriculture Faculty, Çukurova University between 2017 and 2018. Life table data were analyzed by using …

Postpartum Uterine Involution And Ovarian Follicular Dynamics In Crossbreed Anatolianwater Buffalo (Bubalus Bubalis) During Summer Season, Oktay Yilmaz, Ebubeki̇r Yazici, Hasan Çi̇çek, Haci Ahmet Çeli̇k, Cangi̇r Uyarlar, Mehmet Uçar

Turkish Journal of Veterinary & Animal Sciences

It was aimed to monitor postpartum (pp) uterine involution and follicular wave pattern by transrectal ultrasonography and detection of concentrations of milk progesterone (P4) in eleven water buffaloes during the summer season in Turkey. The data obtained from the first day of calving to positive pregnancy diagnosis were evaluated on a daily basis. Uterine position scores and nonechogenic material showed a decreasing grade pattern related to the time (P < 0.0001). A time effect was evident with uterine horn thickness (P < 0.05) or intercaruncular zone thickness (P < 0.01) and uterine horn lumen (P < 0.01). Uterine horn thickness showed a gravidity x time interaction (P < 0.05). Gravidity x time interaction was not evident in total uterine horn thickness but time effect was seen (P < 0.0001). Time effect was also evident for the thickness of uterine body (P < 0.0001) and cervix uteri (P < 0.01). The uterine body and horns were returned to previously nongravid state on day 26.00 ± 2.38 and the interval from calving to complete disappearance of uterine fluid was accomplished on day 31.44 ± 3.23 pp. The previously gravid and nongravid uterine horns, uterine body and cervix uteri involuted on day 31.42 ± 1.39, 28.37 ± 0.65, 29.37 ± 0.73 and 27.87 ± 0.47 pp, respectively. The interval from calving to first observation of dominant follicle of nonovulatory wave was 18.54 ± 6.91 days and on average 3.45 ± 1.91 nonovulatory waves were observed. Postpartum first ovulation occurred on day 64.45 ± 18.49. One and two wave models or combination of both waves were observed. The interval from calving to pregnancy was 72.36 ± 21.33 days. The maximum concentrations of milk P$_{4}$ during short or normal cycles and pregnancy were 0.62 ng/mL, 2.2 ng/mL, and 4.04 ng/mL, respectively. In conclusion, the presence of one or two waves should be considered when estrous synchronization programmes are planned in Anatolian water buffaloes during summer season.

The Effects Of Propofol-Sevoflurane, Midazolam-Sevoflurane, And Medetomidineketamine-Sevoflurane Anesthetic Combinations On Tear Production Measured By Theschirmer Tear Test I (Stt I) In Healthy Rabbits, Hani̇fi̇ Erol, Muharrem Erol, Gülteki̇n Atalan, Cengi̇z Ceylan, Muhammed Kaan Yönez

Turkish Journal of Veterinary & Animal Sciences

The maintenance of corneal and normal eye function is necessary for the ocular health and integrity. Tear plays an important role in defense mechanism and nutrition of eye. The Schirmer tear tests (STT I, II) are widely used in ophthalmic examination to evaluate tear production as an aid to diagnose eye diseases. The aim of this study was to compare the different effect of anesthetic combinations and their action period on tear production in healthy rabbits. Forty healthy New Zealand female rabbits (mean weight 2.34 ± 0.67 kg), four months old, were used as materials. The animals were divided into …

Molecular Characterization Of Vp2 And Vp3 Proteins Of Chicken Anemia Virus Isolates Inturkey, Sezer Okay, Şi̇nasi̇ Aşkar

Turkish Journal of Veterinary & Animal Sciences

Chicken anemia virus (CAV) has a circular 2.3 kb DNA genome encoding VP1, VP2, and VP3 proteins. VP1 protein is assembled into viral capsid. VP2 is a nonstructural protein required for the correct assembly of VP1. Also, there is an interaction between VP2 and VP3 protein, known as apoptin. Mostly, VP1 protein of CAV isolates have been investigated in previous studies but the information about VP2 and VP3 proteins is insufficient. The aim of this study is molecular characterization of VP2 and VP3 proteins from 20 CAV isolates previously collected in different regions of Turkey using in silico tools. The …

Effects Of Milk Replacer And Whole Milk Feeding On Rumen Development, Expression Ofgenes Related To Volatile Fatty Acid Absorption, And Rumen Bacteria In Calves, Ahmet Ceylan, Ali̇ Çalik, Burcu Eki̇m, Alev Gürol Bayraktaroğlu, Oğuz Çalişici, Doğukan Özen, Pinar Saçakli

Turkish Journal of Veterinary & Animal Sciences

This research examined the effects of liquid feeds on calf performance, rumen development, rumen cellulolytic bacteria count, and total bacteria diversity. Twenty Holstein bull calves were allocated to 2 groups either fed with milk replacer (MR) or whole milk. Calves fed milk tended to have higher (P = 0.058) average daily weight gain as compared to calves fed with MR during the entire experimental period. Starter mixture intake was not influenced by either milk or milk replacer feeding. Calves fed with milk had higher (P < 0.001) proliferative cells in the rumen papilla. The expressions of MCT1, MCT4, NHE1, NHE3, ACSS1, AceCS2, and ACSM1 genes, which are related to volatile fatty acid absorption, in the dorsal sac of the rumen were similar for calves fed either MR or whole milk. Fibrobacter succinogenes (P = 0.017) and Ruminococcus flavefaciens (P = 0.037) were significantly higher in the rumen of the milkfed calves. Moreover, denaturing gradient gel electrophoresis (DGGE)-derived dendrograms showed noticeable differences in ruminal microbial population between MR-fed and milk-fed calves. In conclusion, feeding calves with whole milk, which contains better quality protein and nutrients, instead of milk replacers, positively affects rumen development, cellulolytic bacteria numbers and total bacteria diversity.

The Morphometric And Erythrometric Analyses Of Pelophylax Ridibundus Living In Anthropogenic Pollution Resources, Mesut Dönmez, Turgay Şi̇şman

Turkish Journal of Zoology

The health status of Pelophylax ridibundus species living in anthropogenic pollution sources in Erzurum (Turkey) were investigated. Firstly, heavy metal concentrations in liver of the frog species, and in water and sediment samples taken from the habitats of the frogs were determined by instrumental analysis. Secondly, morphometric (fluctuating asymmetry-FA, hepatosomatic index- HSI) and erythrometric analyses were performed to reveal the health status of the frogs in the areas. Our study provides the first morphometric datas on the frog in Turkey. Although the metal concentrations in the water were high, it was determined that they did not exceed the limit values. …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Immunohistological Effects Of Transforming Growth Factor-Ss Via Platelet-Rich Plasma Onsegmental Bone Defects: An Animal Study, Azi̇z Ati̇k, Serdar Sargin, Gökhan Meri̇ç, Cengi̇z Ceylan

Turkish Journal of Veterinary & Animal Sciences

Bone healing is a different and unique process that results in complete bone tissue, rather than ending in scar formation. However, more significant bone defects may fail to regenerate and forms scary granulomatous tissue. This study aimed to investigate the efficacy of transforming growth factor-ß (TGF - ß) via platelet rich plasma (PRP) in rabbit tibia bones with segmental bone defects by radiological and immunohistological methods. Tibial segmental defects were performed to adult New Zealand rabbits (n = 10) on both legs. 0.5 mL of PRP was administered to the defect zone on one leg (PRP group), while the other …

The Morphological And Morphometric Characteristics Of Alabadem Pigeons, Evren Erdem, Fatma Tüli̇n Özbaşer, Eser Kemal Gürcan, Mehmet İhsan Soysal

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine the morphological and morphometric characteristics of Alabadem pigeons, which are grown as ornamental pigeons in Edirne province, and to determine mutual traits with other indigenous pigeon breeds in Turkey by comparing with previous studies. Body weight (P < 0.001), head length (P < 0.01), head width (P < 0.05), beak length (P < 0.001), and tarsus diameter (P < 0.05) of age group III were higher than those of other age groups; however, the wingspan of age group II was greater than that of other age groups in Alabadem pigeon. Compared to other indigenous genotypes in Turkey, the Alabadem pigeon is a small-sized genotype. Alabadem pigeons were similar to Edremit butterfly pigeons and Thracian tumbler pigeons in terms of crested and blackeyed pigeons. On the other hand, the irregularly shaped mark (almond) on the head in Alabadem pigeons was similar to the wide-long irregular shaped mark on the neck of Edremit butterfly pigeons. Some basic plumage colors (black, yellow, and red) and intermediate colors (chickpea and scarlet) were identical to Alabadem pigeons and Thrace roller pigeons. Since Alabadem pigeons have many mutual characteristics with Edremit butterfly pigeons and Thracian roller pigeons, genetic studies may be recommended to determine the degree of relationship among these breeds.

Novel Fast Terminal Sliding Mode Controller With Current Constraint Forpermanent-Magnet Synchronous Motor, Yao Fang, Huifang Kong, Daoyuan Ding

Turkish Journal of Electrical Engineering and Computer Sciences

Under the noncascade structure, the balance between q-axis current constraint and dynamic performance in permanent-magnet synchronous motor system has become a critical problem. On the one hand, large transient current is required to provide high torque to achieve fast dynamic performance. On the other hand, current constraint becomes a state constraint problem, instead of governing q-axis reference current in the cascade structure directly. Aiming at this issue, a novel fast terminal sliding mode control (FTSMC)-based controller with current constraint is developed in this paper. The novelty of this scheme is related to the proposed penalty function based on interior point …

Phase 1 Trial Of Alrn-6924, A Dual Inhibitor Of Mdmx And Mdm2, In Patients With Solid Tumors And Lymphomas Bearing Wild-Type Tp53, Guilherme Rabinowits

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Abstract

Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by MDM2 and MDMX to induce cell cycle arrest or apoptosis in TP53 wild-type tumors.

Methods: Two schedules were evaluated for safety, pharmacokinetics, pharmacodynamics, and anti-tumor effects in patients with solid tumors or lymphomas: In arm A, patients received ALRN-6924 by intravenous infusion once-weekly for 3 weeks every 28 days; arm B, was twice-weekly for 2 weeks every 21 days.

Results: Seventy-one patients were enrolled: 41 in arm A (0.16-4.4 mg/kg), 30 in arm B (0.32-2.7 mg/kg). ALRN-6924 showed dose-dependent pharmacokinetics and …

Lycopene Sensitizes The Cervical Cancer Cells To Cisplatin Via Targeting Nuclear Factorkappab (Nf-��B) Pathway, Oktay Hali̇t Aktepe, Taha Koray Şahi̇n, Gürkan Güner, Zafer Arik, Şuayi̇b Yalçin

Turkish Journal of Medical Sciences

Background/aim: Lycopene is associated with anticancer effects in various tumor types. However, the exact underlying mechanisms of action of lycopene in human cervical cancer remain to be determined. This study aimed to determine anticancer efficacy and mechanism of lycopene in human cervical carcinoma (HeLa) cells. Materials and methods: HeLa cells were treated with cisplatin (1 μM) alone, lycopene (10 μM) alone, and in combination for 72 h. The cell viability of HeLa cells was assessed via MTS assay. Western blot was used to analyze the expression levels of the nuclear factor-kappa B (NF-ΚB), B-cell-associated X protein (Bax), nuclear factor erythroid …

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Turkish Journal of Medical Sciences

No abstract provided.

The Effect Of Induction Loop System Use Training On Adults With Hearing Aids, Merve Burcu Özay, Hüseyi̇n Özay, Selhan Gürkan, Serpi̇l Mungan Durankaya, Tahsi̇n Oğuz Başokçu, Günay Kirkim

Turkish Journal of Medical Sciences

Background/aim: The study aimed to investigate the effect of training on hearing aid users to benefit from induction loop systems. Materials and methods: A five-question scale was developed to evaluate whether individuals using hearing aids could use the induction loop system effectively. In the first step, validity-reliability studies were performed with 264 individuals using hearing aids. In the second step, 30 individuals using hearing aids were given verbal and hands-on training on the induction loop system. Before and after training with hearing aids (noiseless, noise, noise + induction system active) in three different environments, questions on the scale were asked …

Turkish Reliability And Validity Study Of The Medical Outcomes Study (Mos) Sleep Scale Inpatients With Obstructive Sleep Apnea, Bülent Devri̇m Akçay, Duygu Akçay, Si̇nan Yetki̇n

Turkish Journal of Medical Sciences

Background/aim: The purpose of the present study was to evaluate the Turkish reliability and validity of the medical outcomes study (MOS) sleep scale in patients who have obstructive sleep apnea. Materials and methods: The data of the study were collected from 120 adult patients with obstructive sleep apnea and from 90 healthy individuals between March 04 and May 31, 2019. Results: The Cronbach's α internal consistency reliability coefficient of the MOS sleep scale was found as 0.82. The test-retest reliability was acceptable (r = 0.76-0.94). Six factors were identified by the factor analysis. These were the same as those in …

Muc1 And Muc5ac Implication In Tunisian Colorectal Cancer Patients, Meriam Hazgui, Marwa Weslati, Rahma Boughriba, Donia Ounissi, Dhouha Bacha, Saadia Bouraoui

Turkish Journal of Medical Sciences

Background/aim: Mucins, such as MUC1 and MUC5AC, are known for their protective and moisturizing role in intestinal epithelium. Their expression is tightly controlled given their essential role in normal tissue homeostasis, whereas their deregulation leads to chronic inflammation, and even cancer. This study aimed to assess the expression profiles of MUC1 and MUC5AC and their implications in colorectal carcinogenesis. Materials and methods: A retrospective study of 202 patients who underwent colorectal cancer (CRC) surgery was conducted. The expression of MUC1 and MUC5AC was investigated by immunohistochemistry and reverse-transcription polymerase chain reaction (RT-PCR). Statistical analysis of mucin expression pattern, as well …

Diagnostic Efficacy Of Apparent Diffusion Coefficient Measurements In Differentiation Ofmalignant Intra-Axial Brain Tumors, İlker Eyüboğlu, İsmet Mi̇raç Çakir, Serdar Aslan, Ahmet Sari

Turkish Journal of Medical Sciences

Background/aim: To evaluate diagnostic efficacy of the apparent diffusion coefficient measurements from tumor (ADCt) and tumor circumference hyperintensities (ADCtch) in different types of malignant intra-axial brain tumors. Materials and methods: Between April 2013 and June 2017, 125 patients (52 females (41.6%) and 73 males (58.4%); mean age: 53 years, age range: 14-81 years), who underwent diffusion-weighted imaging (DWI) with intracranial mass, were retrospectively evaluated. The mean ADCt and ADCtch values and ratios were measured. Results: Of the 125 patients, 22 (17.6%) had a low-grade glioma (LGG), 55 (44%) had a high-grade glioma (HGG), 32 (25.6%) had metastasis, and 16 (12.8%) …

Efficacy, Retention, And Safety Of Tofacitinib In Real-Life: Hur-Bio Monocentric Experience, Emre Bi̇lgi̇n, Furkan Ceylan, Emi̇ne Duran, Bayram Fari̇soğullari, Ertuğrul Çağri Bölek, Gözde Kübra Yardimci, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Umut Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: To assess the real-life efficacy, retention rate, and safety data of tofacitinib in rheumatoid arthritis (RA) patients. Materials and methods: We analyzed all patients registered in the HURBİO database who received at least 1 dose of tofacitinib. Patients who received at least one dose were included in retention analysis; patients with at least 1 control visit were included in efficacy and safety analysis. Factors predicting good response at the last follow-up visit were analyzed by logistic regression analysis. Drug retention rates were calculated using the Kaplan-Meier method and predictors of drug retention were determined by Cox proportional hazard model. …

Joint Optimization Of Target Wake Time Mechanism And Scheduling For Ieee802.11ax, Mehmet Karaca

Turkish Journal of Electrical Engineering and Computer Sciences

IEEE 802.11ax as the newest wireless local area networks (WLANs) standard brings enormous improvements in network throughput, coverage and energy efficiency in densely populated areas. Unlike previous IEEE 802.11 WLAN standards where power saving mechanisms have a limited capability and flexibility, 802.11ax comes with a different mechanism called target wake time (TWT) where stations (STAs) wake up only after each TWT interval and different STAs can wake up at different time instance depending on their application requirements. As an example, for a periodic data arrival occurring in IoT applications, STA can wake up by following the data period and go …