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2021

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Comparative Response Of Dendritic Cells To Pathogenic And Non-Pathogenic Leptospira Spp., Pratomporn Krangvichian Jan 2021

Comparative Response Of Dendritic Cells To Pathogenic And Non-Pathogenic Leptospira Spp., Pratomporn Krangvichian

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospirosis is a zoonotic disease caused by pathogenic Leptospira species, which consist of three groups and contain 4 subclades: pathogenic strains (P1), intermediate strains (P2), and non-pathogenic strains (S1 and S2). Infection of pathogenic leptospires occurs through contact with contaminated environments. Then, leptospires present in the bloodstream disseminate to target organs. Nowadays, the knowledge of the immune response to pathogenic and non-pathogenic leptospires during early infection is still limited. Due to the limitation of a susceptible host, immunological reagents for hamsters and strains of mice are limited and not available. Dendritic cells are the first cells to encounter leptospires found …

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Designing An Extracorporeal Plasma Filtration Column With Specific Binding To Dengue Virions, Sasiwimon Thonghong Jan 2021

Designing An Extracorporeal Plasma Filtration Column With Specific Binding To Dengue Virions, Sasiwimon Thonghong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dengue infection is one of the major public health concerns and no specific treatment is currently available. An extracorporeal system is one of the alternative treatment in severe dengue patients with impending shock. However, the commercial immunoadsorption devices were size-exclusive, non-selective designed for multipurpose thus not specific for dengue syndrome. This study focuses on establishing the flavivirus-specific (4G2) antibody entrapped into the alginate bead. Results showed that the viral titer reduced more than 90 % after 3 h running on a simulated circuit quantified by reverse transcription qPCR and plaque titration assay. The experiments were repeated with two biological replicates …

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The Synergistic Activity Of Antibiotic Combinations Against Colistin-Resistant Acinetobacter Baumannii Clinical Isolates And Its Mechanisms Related To Colistin Resistance, Sukrit Srisakul Jan 2021

The Synergistic Activity Of Antibiotic Combinations Against Colistin-Resistant Acinetobacter Baumannii Clinical Isolates And Its Mechanisms Related To Colistin Resistance, Sukrit Srisakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The increasing development of colistin resistance in Acinetobacter baumannii clinical isolates is a global concern. Due to the limitation of effective antibiotics, the antibiotic combination therapies are the alternative choices. Here, we investigated the prevalence of colistin resistant A. baumannii (CoR-AB) clinical isolates and their resistance mechanisms, and examined the in vitro synergistic activities of the antibiotic combinations against CoR-AB. Among 341 carbapenem-resistant Acinetobacter spp., 317 (92.0%) were identified as A. baumannii by gyrB multiplex PCR. The rate of colistin resistance was 15.1% in A. baumannii isolates with MIC range of 0.125 – 64 mg/L. A total of 30 representative …

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Endotoxemia From Nsaids-Induced Gut-Leakage Enhanced Lupus Characteristics In Fc Gamma Receptor Iib Deficient Lupus Mice, Thansita Bhunyakarnjanarat Jan 2021

Endotoxemia From Nsaids-Induced Gut-Leakage Enhanced Lupus Characteristics In Fc Gamma Receptor Iib Deficient Lupus Mice, Thansita Bhunyakarnjanarat

Chulalongkorn University Theses and Dissertations (Chula ETD)

High dose of non-steroidal anti-inflammatory drugs (NSAIDs), the common analgesia, might induce lupus activity through NSAIDs-induced gastrointestinal permeability defect (gut leakage) that causes endotoxemia. Indomethacin (25 mg/day) was orally administered for 7 days in 24-week-old Fc gamma receptor IIb deficient (FcgRIIb-/-) mice, an asymptomatic lupus model, and age-matched wild-type (WT) mice. The severity of indomethacin-induced enteropathy in FcgRIIb-/- mice was higher than WT mice as demonstrated by intestinal injury (histology, immune-deposition and intestinal cytokines), gut leakage (FITC-dextran assay and endotoxemia) and serum cytokines. In addition, higher responses against endotoxemia in indomethacin-administered FcgRIIb-/- mice was also supported by the prominent responses …

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Impact Of Bacterial Dna In Severity Of Sepsis, Warerat Kaewduangduen Jan 2021

Impact Of Bacterial Dna In Severity Of Sepsis, Warerat Kaewduangduen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bacterial sepsis can be caused by intestinal damage, leading to the passage of viable bacteria and their components into the circulatory system. Bacterial-free DNA in the blood during sepsis can be derived from bacterial death and intestinal translocation of free DNA in the gut contents. The presence of bacterial DNA in combination with lipopolysaccharide (LPS) can lead to more serious outcomes of sepsis. To explore the impact of bacterial-free DNA in sepsis, animal and macrophage experiments were performed. Firstly, the appearance of bacterial-free DNA and bacteriome in the blood was presented in mice with cecal ligation and puncture sepsis. Secondly, …

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Dosimetric Comparison Of Rapidplan And Manually Optimized Plans For Hippocampus Avoidance Whole Brain Radiation Therapy, Laksamon Phimolasawakun Jan 2021

Dosimetric Comparison Of Rapidplan And Manually Optimized Plans For Hippocampus Avoidance Whole Brain Radiation Therapy, Laksamon Phimolasawakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, whole-brain radiation therapy (WBRT) is a good method to cure brain metastases. However, it has been noted that whole-brain radiation therapy could be a cause to neurological toxicity which could damage the hippocampus that is an important part of forming long-term memories. The HA-WBRT is a complicated plan depending on planner skills, the researcher would like to simplify this problem using knowledge-based planning called RapidPlan. The objective of this study was to compare the dosimetric difference of RapidPlan and manually optimized plans for the treatment of HA-WBRT. The RapidPlan model was created for HA-WBRT. The PTV and OARs constraints …

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Hepatic Lesion Detectability On Dual Energy Computed Tomography Imaging : Phantom Study, Hataipat Jantawong Jan 2021

Hepatic Lesion Detectability On Dual Energy Computed Tomography Imaging : Phantom Study, Hataipat Jantawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study is to determine the hepatic lesion detectability in abdomen from various phantom sizes by dual-energy computed tomography (DECT) imaging and to investigate the factors affecting the detectability of hepatic lesion in abdomen by dual-energy CT in phantom study. The anthropomorphic liver with nodule inserted phantom with extension rings simulating the small, medium, and large patients were scanned under DECT acquisitions by varying three kVp combinations (80/-,90/-, and 100/Sn150-kVp). The series of 40-,50-,60-, and 70-keV VMI were generated from DECT data set. All images were used to assess the task-based image quality; task transfer function (TTF), …

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Determination Of Field Output Correction Factors In Elongated Small Field Photon Beams, Mananchaya Vimolnoch Jan 2021

Determination Of Field Output Correction Factors In Elongated Small Field Photon Beams, Mananchaya Vimolnoch

Chulalongkorn University Theses and Dissertations (Chula ETD)

IAEA along with AAPM have published a code of practice TRS 483 for small field dosimetry. The field correction output factors of various detectors were introduced to correct detector response changes in relative dosimetry. However, the publication of TRS 483 has focused on symmetry field sizes, the correction factors for elongated small fields are not included in the protocol. The overall objective of this work is to determine the field output correction factor in elongated small field. The correction factors of IBA CC01, Sun nuclear EDGE, and Exradin W2 PSD for 6 MV photon beam were determined using Monte Carlo …

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Evaluation Of Integral Depth-Dose Curves In Proton Pencil Beam Scanning Using Plane-Parallel Ionization Chambers, Phatthraporn Thasasi Jan 2021

Evaluation Of Integral Depth-Dose Curves In Proton Pencil Beam Scanning Using Plane-Parallel Ionization Chambers, Phatthraporn Thasasi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Proton therapy is an advanced form of radiation therapy treatment that can potentially decrease side effects and increase tumor control probability. The integral depth-dose curve is an essential parameter that has to be determined and introduced into the proton treatment planning system for the dose calculation. Besides the halo, the integral depth-dose curve measurements should be performed with a large-diameter plane-parallel ionization chamber. The purpose of this research is to determine the integral depth-dose curves and assess the geometrical collection efficiency at intermediate depths of different detector diameters in proton pencil beam scanning. The integral depth-dose curves with a proton …

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Baselines Of Daily Quality Assurance For Proton Pencil Beam Scanning Using The Sphinx Compact, Tanapat Tiajaroen Jan 2021

Baselines Of Daily Quality Assurance For Proton Pencil Beam Scanning Using The Sphinx Compact, Tanapat Tiajaroen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Quality assurance (QA) is a systematic process used to determine whether the product meets specified requirements. The American Association of Physicists in Medicine (AAPM) published a comprehensive proton therapy machine QA in TG-224 to provide confidence in use. King Chulalongkorn Memorial Hospital (KCMH) recently operated the first proton therapy center in Thailand, and the data of daily QA are not available or established. This study aims to apply the control chart for establishing the baselines of daily QA for the proton pencil beam scanning system using the Sphinx Compact detector. The Sphinx Compact was used to perform the proton daily …

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Moderated Neutron Detector For Accumulated Ambient Dose Equivalent In Proton Therapy, Tanawat Tawonwong Jan 2021

Moderated Neutron Detector For Accumulated Ambient Dose Equivalent In Proton Therapy, Tanawat Tawonwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Varian ProBeam compact was installed at Her Royal Highness Princess Maha Chakri Sirindhorn Proton Center. Since 2017, the project has started at the King Chulalongkorn Memorial Hospital and after 4 years, during Covid19 pandemic, the 1st patient treatment received proton therapy on August, 2021. The radiation safety of the center was accomplished through firstly, the shielding calculation and secondary, the radiation survey at the milestone points such as cyclotron installation and 1st Beam ON at the treatment room. The only one WENDI-II dosimeter was used in radiation survey. The main purpose of this study is to validate the in-house …

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Dosimetric Impact Of Interplay Effects Instereotactic Body Radiation Therapy (Sbrt) Lung Cancer, Vanida Poolnapol Jan 2021

Dosimetric Impact Of Interplay Effects Instereotactic Body Radiation Therapy (Sbrt) Lung Cancer, Vanida Poolnapol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lung cancer patient breathing induced interplay effects in the volumetric modulated arc therapy (VMAT) together with stereotactic body radiation therapy (SBRT), which lead to non-uniform doses within the target volume and unwanted dose to the surrounding tissues. The purpose of this study was to investigate the dosimetric impact of interplay effects in 6 MV FFF of photon beams for lung cancer and to calculate the novel interplay effects factor (IEF) for VMAT-SBRT lung cancer. This study performed the static and dynamic measurements using two dimensions (2D) robotic platform and diode array for 3D-conformal radiation therapy (3D-CRT) plans, while using three …

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Localization Chulalongkorn University Of The Infraorbital Foramen And The Accessory Infraorbital Foramen With Reference To Facial Bony Landmarks: The Predicting Method And Its Accuracy., Jiraporn Suntiruamjairucksa Jan 2021

Localization Chulalongkorn University Of The Infraorbital Foramen And The Accessory Infraorbital Foramen With Reference To Facial Bony Landmarks: The Predicting Method And Its Accuracy., Jiraporn Suntiruamjairucksa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The infraorbital nerve block is commonly used for mid-facial anesthesia. Therefore, the location of infraorbital foramen (IOF) and accessory infraorbital foramen (AIOF) where the nerve exits through is important. Although, many studies tried to identify the location of IOF and AIOF using bony and soft tissue landmarks, the results varied in each study. Objectives To determine the location of IOF and AIOF with reference to the line between anterior nasal spine (ANS) and the lowest point of the zygomaticomaxillary junction (Z) which is defined as line A, describe anatomical relationship between IOF and AIOF, and assess an accuracy of the …

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Identification Of Shared Neoantigens In Brca1-Related Breast Cancer, Lucksica Ruangapirom Jan 2021

Identification Of Shared Neoantigens In Brca1-Related Breast Cancer, Lucksica Ruangapirom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Personalized neoantigen-based cancer vaccine has been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and brings about delay in treatment. Using off-the-shelf cancer vaccine by targeting shared neoantigen may circumvent these problems. We identified BRCA1-mutated breast cancer as a candidate for shared neoantigens because of its clinical aggressiveness and its genotypic and phenotypic similarities suggesting common somatic mutational events within the group. Therefore, we hypothesized that shared-neoantigen may be identified among BRCA1-related breast cancer and may be used as targets for shared neoantigen vaccine. For analyses, we obtained genome sequencing data of …

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Identification Of Snp Barcode For Classify Carbapenem-Resistant Enterobacteriaceae (Cre) And Non-Cre Using Nanopore Sequencing, Nicha Sangpiromapichai Jan 2021

Identification Of Snp Barcode For Classify Carbapenem-Resistant Enterobacteriaceae (Cre) And Non-Cre Using Nanopore Sequencing, Nicha Sangpiromapichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The continuous increase of carbapenem-resistant Enterobacteriaceae (CRE) prevalence has been a serious problem for public health worldwide. In the previous study, 25% of 3864 Klebsiella pneumoniae isolates were carbapenem-resistant. One of the most important risks of bacterial drug resistance is the improper use of antibiotics. The routine antimicrobial-susceptibility test requires overnight and has a turnaround time of approximately 2–3 days which delays the proper antibiotics. This study aims to develop a technique to classify CRE and non-CRE by SNP barcode. Method: Forty Klebsiella pneumoniae (KP) clinical isolates were collected from 2020–2021 at King Chulalongkorn Memorial Hospital. Twenty samples were …

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Ultrastructural Changes Of Endothelial Cell, Pericyte And Vascular Basement Membrane In Cisplatin-Induced Neuropathy In Rats: Correlation With Neuropathic Changes After Treatments, Phetnarin Kobutree Jan 2021

Ultrastructural Changes Of Endothelial Cell, Pericyte And Vascular Basement Membrane In Cisplatin-Induced Neuropathy In Rats: Correlation With Neuropathic Changes After Treatments, Phetnarin Kobutree

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cisplatin is an antineoplastic agent used to treat cancers of several organs. Peripheral neuropathy is one of its major side effects leading to dose reduction or cessation. Underlying mechanisms of cisplatin-induced neuropathy are not fully understood. According to current evidence, vascular dysfunction may play a role. Curcumin is a polyphenol found in the root of Curcuma longa with the anti-oxidant property and neuroprotection. Curcumin has shown effectiveness against experimental cisplatin neuropathy. B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism and maintaining nervous system functions. Increasing evidence suggests the efficacy of vitamin B1-6-12 for …

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Study Of G6pd Deficiency With Clinical And Hematological Correlation In Newborn Infants, Thanaporn Pimpakan Jan 2021

Study Of G6pd Deficiency With Clinical And Hematological Correlation In Newborn Infants, Thanaporn Pimpakan

Chulalongkorn University Theses and Dissertations (Chula ETD)

G6PD deficiency is the most common enzymatic aberration, affecting more than a million people worldwide. If severe cases at birth are not diagnosed and treated promptly, they can develop into cerebral jaundice and hyperbilirubinemia. Hyperbilirubinemia is caused by an imbalance between increased bilirubin production and ineffective excretion of bilirubin. This can result in the neurotoxicity of bilirubin, kernicterus, and fatal mental retardation. Besides, It has been speculated that the presence of a high number of reticulocytes in newborns interferes with the diagnosis of G6PD deficiency since reticulocytes contain higher amounts of G6PD enzyme than mature erythrocytes. Therefore, the purposes of …

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Precise Extratemporal Pattern And Intramuscular Distribution Of The Facial Nerve, Sukanya Uruwan Jan 2021

Precise Extratemporal Pattern And Intramuscular Distribution Of The Facial Nerve, Sukanya Uruwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

An arborization of the branches of the facial nerve has the most complexity and variability. Moreover, knowledge of the facial nerve has great importance for surgical and non-surgical interventions in the face region. However, few studies have attempted to determine the entire course and pattern of terminal branching of the facial nerve in the extratemporal and intramuscular parts of the face. Therefore, the purpose of this study was to investigate the precise detail of the facial nerve in extratemporal and intramuscular parts. This study was conducted in forty-two hemifaces of embalmed cadavers by conventional dissection, fourteen hemi-faces of embalmed cadavers …

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Effects Of Strongyloides Stercoralis Antigens On Immune Responses In Dendritic Cells, Vittawin Sutaveesup Jan 2021

Effects Of Strongyloides Stercoralis Antigens On Immune Responses In Dendritic Cells, Vittawin Sutaveesup

Chulalongkorn University Theses and Dissertations (Chula ETD)

Strongyloidiasis is a parasitic disease caused by Strongyloides stercoralis. Infection in the immunocompromised hosts such as organ transplants, SLE patients, or HIV and HIPV infected patients can cause severe strongyloidiasis. Infected patients have high levels of Th2, and Treg related cytokines, including IL-4, IL-5, IL-9, IL-10, IL-13, and TGF-β. These cytokines are then decreased to normal levels after the treatments. Parasites have several mechanisms to suppress or evade the host’s immune response, such as suppressing the expression of co-stimulatory molecules on antigen-presenting cells (APCs), stimulating apoptosis of APCs, or stimulating Th2 and Treg responses. Dendritic cells (DCs) play a crucial …

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An Anatomical Study Of The Central Myelin Portion And Transitional Zone Of The Oculomotor And Abducens Nerves, Wiyada Quanchareonsap Jan 2021

An Anatomical Study Of The Central Myelin Portion And Transitional Zone Of The Oculomotor And Abducens Nerves, Wiyada Quanchareonsap

Chulalongkorn University Theses and Dissertations (Chula ETD)

Neurovascular syndrome is a dysfunction of an individual cranial nerve which is compressed by vessels. Several neurovascular compression syndromes are well known such as trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia. Having neurovascular conflicts at oculomotor nerves and abducens nerve cause ocular neuromyotonia and abducens nerve palsy. Site of compression is still controversial because of unclear definition. The term root entry/ exit zone (REZ) is defined variously and used interchangeably with transitional zone making it hard to compare between studies. It is generally thought to be at transitional zone which is defined as junction between central and peripheral nervous system. …

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A Pilot Study, Randomized Control Trial On Effect Of Oral Calcium Carbonate To Fecal Functional Levofloxacin Concentration In Healthy Volunteer Taking Oral Levofloxacin, Ophat Janphet Jan 2021

A Pilot Study, Randomized Control Trial On Effect Of Oral Calcium Carbonate To Fecal Functional Levofloxacin Concentration In Healthy Volunteer Taking Oral Levofloxacin, Ophat Janphet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: We conducted a pilot randomized control trial (RCT) to study whether oral calcium carbonate (CaCO3) can lower fecal levofloxacin (LVX) concentration and preserve gut microbiota diversity in healthy volunteers. Methods: The healthy volunteers received a 5-day course of once-daily 500 mg LVX oral tablet and were randomly assigned to treatment (6-day course of 1,000 mg CaCO3 oral tablet twice daily) and control group (no CaCO3). The primary outcome was fecal LVX concentration by MIC and high-performance liquid chromatography (HPLC) on day 2 and 5. The secondary outcomes were fecal microbiota diversity Shannon index (H) by 16s rDNA analysis, plasma …

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Attenuation Of Chronic Kidney Disease (Ckd) And Uremia Induced Gut-Leakage By Lactobacillus Rhamnosus L34, A Probiotic Derived From Thai Population, In 5/6 Nephrectomy Model Mice; An Experimental Study, Somkanya Tungsanga Jan 2021

Attenuation Of Chronic Kidney Disease (Ckd) And Uremia Induced Gut-Leakage By Lactobacillus Rhamnosus L34, A Probiotic Derived From Thai Population, In 5/6 Nephrectomy Model Mice; An Experimental Study, Somkanya Tungsanga

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Although pathogenic gut microbiota causes gut leakage, increases translocation of uremic toxins into circulation, and accelerates CKD progression, the local strain of Lactobacillus rhamnosus L34 (L34) might attenuate gut leakage. We explored the effects of L34 on kidney fibrosis and levels of gut-derived uremic toxins (GDUTs) in 5/6-nephrectomy (5/6 Nx) mice. Methods: At 6 weeks post-5/6 Nx in mice, either L34 (1x106 CFU) or phosphate buffer solution (as 5/6 Nx control) were daily fed for 14 weeks. In vitro, the effects of L34-conditioned media with or without indoxyl sulfate (a representative GDUT) on inflammation and cell integrity (transepithelial electrical …

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Tuning The Wettability Of Metal Surface With Electrodeposited Porous Copper And Graphene Coatings, Husam Eltigani Jan 2021

Tuning The Wettability Of Metal Surface With Electrodeposited Porous Copper And Graphene Coatings, Husam Eltigani

Chulalongkorn University Theses and Dissertations (Chula ETD)

Electrodeposition of porous copper is an interesting type of coating that is emerging for various applications. However, the understanding of the relationships between copper surface wettability control and electrodeposition parameters and post-electrodeposition storage conditions is quite limited. Furthermore, it is worthwhile to explore how nanomaterials such as graphene would interact with porous copper to provide surface wettability modifications. This work therefore aims to develop a framework for the relationship of copper and graphene deposition processes, storage conditions, and the wetting behavior of copper surfaces. The research work performed in this study is divided into 2 parts: (i) effects of plating …

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Effect Of Dielectric Barrier Discharge Plasma Hydrogenation On Oxidation Stability Of Biodiesel Derived From Vegetable Oils, Grittima Kongprawes Jan 2021

Effect Of Dielectric Barrier Discharge Plasma Hydrogenation On Oxidation Stability Of Biodiesel Derived From Vegetable Oils, Grittima Kongprawes

Chulalongkorn University Theses and Dissertations (Chula ETD)

A parallel-plate type dielectric barrier discharge (DBD) plasma was utilized to produce partially hydrogenated fatty acids methyl ester (PH-FAME) derived from soybean and palm FAME. PH-FAME exhibits improved oxidation resistance, resulting in a longer storage time and a delay in changing fuel properties. The DBD plasma reaction occurred at atmospheric pressure and ambient temperature without a catalyst. The best condition for 35 mL of soybean FAME hydrogenation was using 25% H2 at ambient temperature for 5.5 h. An increase in saturated and monounsaturated FAMEs corresponded to a reduction of iodine value from 128 to 67.4. This condition created trans fatty …

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Production Of Low Trans-Fatty Acid Margarine By Plasma Hydrogenation, Kunlanan Puprasit Jan 2021

Production Of Low Trans-Fatty Acid Margarine By Plasma Hydrogenation, Kunlanan Puprasit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Margarine is a widely used raw material in the food and bakery industry. A successfully novel technique for refined palm olein hydrogenation to free trans-fat margarine production using non-thermal dielectric barrier discharge (DBD) plasma has been demonstrated. The new green method does not use chemicals as a catalyst, thus making it extremely environmentally friendly. This also performs well at room temperature and atmospheric pressure making it easier to manage. Two-electrode arrangement patterns were studied in this research: parallel plate and needle-in-tube. The results showed that using the parallel plate electrodes, 1.44% trans-fat (was detected) and a trans-fat generation rate of …

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Development Of A Personalized Workplace Learning Program To Enhance The Cultural Intelligence Of Cabin Crew From International Airlines, Dech-Siri Nopas Jan 2021

Development Of A Personalized Workplace Learning Program To Enhance The Cultural Intelligence Of Cabin Crew From International Airlines, Dech-Siri Nopas

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis study employed R&D as a research methodology, and employ a qualitative method to collect the data. It aimed to 1) explore the background of cabin crew from the international airlines concerning cultural intelligence from seven key informants; 2) develop personalized workplace learning programs to enhance the cultural intelligence of cabin crew from the international airlines with seven key informants of the cabin crew and the researcher as a facilitator, and 3) propose a guideline for developing a personalized workplace learning program to enhance the cultural intelligence of cabin crew from the international airlines by developing all the findings …

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The Effects Of A Recurrent Stroke Prevention Program On Blood Pressure, Low Density Lipoprotein Cholesterol, And Blood Glucose Among Patients With First Ischemic Stroke, Orapin Jullmusi Jan 2021

The Effects Of A Recurrent Stroke Prevention Program On Blood Pressure, Low Density Lipoprotein Cholesterol, And Blood Glucose Among Patients With First Ischemic Stroke, Orapin Jullmusi

Chulalongkorn University Theses and Dissertations (Chula ETD)

This cluster randomized control trial research with control group and repeated measure. The objectives of this study were to explore the effect of a recurrent stroke prevention program on blood pressure, low density lipoprotein cholesterol, and blood glucose among patients with first ischemic stroke. The participants were the patients who have been diagnosed with first ischemic stroke. They were recruited from two stroke units from two tertiary hospitals in public health region 2, Thailand. Sixty participants were randomly recruited and divided into experimental group (n=30) and control group (n=30). The participants in the experimental group received the recurrent stroke prevention …

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Predictors Of Time To Hospital Among People With Colorectal Cancer, Saimai Tumwijit Jan 2021

Predictors Of Time To Hospital Among People With Colorectal Cancer, Saimai Tumwijit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This retrospective, cross-sectional study aims to describe time to hospital, relating factors, and determine predictors of time to hospital among people with colorectal cancer. Multistage random sampling was used to yield a probability of 240 people with colorectal cancer visiting medical and surgical outpatient departments, oncology units, radiology units, endoscopic units, and inpatient departments. Research instruments consisted of personal information sheet, time to colorectal cancer diagnosis questionnaire, knowledge about colorectal cancer questionnaire (KR-20 = .786), The modified illness perception questionnaire-revised (a = .674 - .836), health care seeking behavior questionnaire (a = .706), and perceived seriousness of warning signs and …

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Effect Of Different Placement Methods On Voids Formationin Class Ii Cavity Restored With Bulk-Fill Resin Composite, Parinthorn Siyoputhawong Jan 2021

Effect Of Different Placement Methods On Voids Formationin Class Ii Cavity Restored With Bulk-Fill Resin Composite, Parinthorn Siyoputhawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study was to evaluate void formation by micro-computed tomography in two-surface Class II cavities restored with two bulk-fill resin composites using different placement methods. Standardized Class II cavities were prepared in forty intact human maxillary first premolar teeth. The teeth were randomly divided into four groups and restored with (n=10): 1) one bulk placement with hand instrument; 2) two-bulk placement with hand instrument; 3) one bulk placement with injectable dispenser; 4) one bulk placement with injectable dispenser and sonic-activated handpiece. Percentage of void formation in the entire restoration was evaluated. Welch's ANOVA and Games-Howell post hoc …

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Factors Influencing The Dentist’S Decision To Propose A Tooth Autotransplantation In The Faculty Of Dentistry, Chulalongkorn University, Thunchanok Sinprasurdsook Jan 2021

Factors Influencing The Dentist’S Decision To Propose A Tooth Autotransplantation In The Faculty Of Dentistry, Chulalongkorn University, Thunchanok Sinprasurdsook

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To study factors which influence a dentist’s decision to propose the Tooth Autotransplantation (AT). Material and methods: A cross-sectional study was conducted among 99 dentists between January and March 2021. A questionnaire comprised demographic characteristics, unprimed scenario, primed scenario, reasoning behind decisions, experience, and knowledge of AT. Data were analyzed using the Chi-square test, McNemar’s test, and multiple logistic regression. Results: The respondents comprised 73 females and 26 males with a mean age of 30.84 ± 6.238 years. In the unprimed scenario, there were significant associations between fields of expertise, experience, knowledge of current indications, outcomes, and the benefits …

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