Digital Commons Network^™

Synthesis And Biomedical Applications Of Functional Polymers, Jianxun Ding, Di Li, Jingxiao Chen, Chao Zhao, Parisa Pour Shahid Saeed Abadi

Michigan Tech Publications, Part 1

No abstract provided.

Forward And Reverse Genetics Of B Cell Malignancies: From Insertional Mutagenesis To Crispr-Cas, Joanna C. Dawes, Anthony G. Uren

School of Biomedical Sciences

Cancer genome sequencing has identified dozens of mutations with a putative role in lymphomagenesis and leukemogenesis. Validation of driver mutations responsible for B cell neoplasms is complicated by the volume of mutations worthy of investigation and by the complex ways that multiple mutations arising from different stages of B cell development can cooperate. Forward and reverse genetic strategies in mice can provide complementary validation of human driver genes and in some cases comparative genomics of these models with human tumors has directed the identification of new drivers in human malignancies. We review a collection of forward genetic screens performed using …

Photobiomodulation Therapy In Head And Neck Cancer-Related Lymphedema: A Pilot Feasibility Study., Jie Deng, John N Lukens, Samuel Swisher-Mcclure, Joy C Cohn, Bryan A Spinelli, Ryan J Quinn, Jesse Chittams, Erin Mcmenamin, Alexander Lin

Department of Medicine Faculty Papers

PURPOSE: Lymphedema is a common debilitating late effect among patients post-head and neck cancer (HNC) treatment. Head and neck lymphedema was associated with symptom burden, functional impairment, and decreased quality of life. The objective of this study was to determine the feasibility and potential efficacy of the use of photobiomodulation (PBM) therapy for head and neck lymphedema, symptom burden, and neck range of motion among HNC survivors.

METHODS: This was a single-arm, pre- and post-design clinical trial. Eligible patients included those with lymphedema after completion of complete decongestive therapy (CDT) and 3 to 18 months after completion of cancer therapy. …

Conservation Of The Ambystoma Jeffersonianum Complex, Morgan Motherwell

Theses

The Great Lakes region is home to the diverse genus Ambystoma, including the Blue Spotted Salamander (Ambystoma laterale) and Jefferson’s Salamander (Ambystoma jeffersonianum). These two species are relevant to conservation efforts because of unique hybrid populations. This hybridization creates offspring populations that are morphologically similar to the parental species. The hybrid populations are primarily all female lineages and are known as the Ambystoma jeffersonianum complex. Conservation interest in this hybrid complex stems from the fact that hybrid populations are not taxonomically recognized as separate species and therefore are not protected under the Endangered Species Act. To assess the contribution of …

Stigma And Social-Emotional Health In Youth With Learning Differences, Kelsey Maki

Doctoral Dissertations

Youth diagnosed with specific learning disorder (SLD) and/or attention deficit hyperactivity disorder (ADHD), defined collectively for the purposes of this study as youth with learning differences, experience poorer social-emotional health outcomes in comparison to their typically developing peers. These youth additionally experience stigma from their peers, teachers, and broader community, which may impact social-emotional health. As a secondary data analysis of a larger study, the present study investigated the role of stigma consciousness alongside demographic variables, self-esteem, and peer relationships in social-emotional health outcomes. Due to the possible differences between youth diagnosed with SLD, ADHD, and comorbid SLD/ADHD, group differences …

Increasing Public Health Mosquito Surveillance In Hidalgo County, Texas To Monitor Vector And Arboviral Presence, Clarissa D. Guerrero, Steven Hinojosa, Diana Vanegas, Niko Tapangan, Matthew Guajardo, Sara Alaniz, Narda Cano, Christopher Vitek, John M. Thomas, Valerie Hernandez, Juan Garcia Jr.

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

From 2016 to 2018, Hidalgo County observed the emergence of Zika virus (ZIKV) infections along with sporadic cases of Dengue virus (DENV) and West Nile virus (WNV). Due to the emergence of ZIKV and the historical presence of other mosquito-borne illnesses, Hidalgo County obtained funding to enhance mosquito surveillance and educate residents on arboviruses and travel risks. During this time period, Hidalgo County mosquito surveillance efforts increased by 1.275%. This increase resulted in >8000 mosquitoes collected, and 28 mosquito species identified. Aedes aegypti, Ae albopictus and Culex quinquefasciatus made up approximately two-thirds of the mosquitoes collected in 2018 (4122/6171). Spatiotemporal …

Celebrating The Msu Faculty: Faculty Awards, Murray State University

Reports

Program celebrating Faculty Awards from 2020 and 2021, distributed at the Murray State University's Welcome Back Luncheon, held under the portico of Waterfield Library on Friday, August 13, 2021.

Aborsi Dalam Perspektif Hukum Islam, Mardani Mardani

Indonesian Journal of International Law

Islam is a religion that has its own law, which is known as an Islamic Law, which has five main aims. And, one of the five main aims is to save and protect the soul of human from any threats, which means to protect the existence of human beings’ lige and the Moslem community. To concrete it, Islam stated the Law for abortion, Qisas and Diyat. This is a sign of the Islamic Law fort to protect the human life. Considering the complicated problem of baortion thus in this article will be explained the views of Islamic Law on abortion

Tropical Deforestation As An International Externality: The Property Right Issue, Endah Murniningtyas

Indonesian Journal of International Law

The developing countries frequently blamed as a party who did the deforestation or do the forest logging. The developed countries try to give a penalty the developing countries with inserting environmental values to trade values. It caused a dispute between the parties because the developing countries highly dependent with the production of the major commodity, whose derived from the forest. In general, approved that the use of natural resources should pay attention the impact to the environment, either it is domestic or global environment. The universal environmental regulation and the environment whose adjusted with the boundaries in trade, in one …

Memerangi Kejahatan Kehutanan Dan Mendorong Prinsip Kehati-Hatian Perbankan Untuk Mewujudkan Pengelolaan Hutan Yang Berkelanjutan Pendekatan Anti Pencucian Uang, Bambang Setiono, Yunus Husein

Indonesian Journal of International Law

If the illegal logging is just a criminal whose involve the poor society which their life depend to the forest, truck driver or forest guards whose underpaid, that criminal would not be difficult to stop. With the involvement of support from the illegal logging funders, which usually called cukong, illegal logging industry and government employees, the illegal logging has become a complex problem, not only in Indonesia, but also for the international forest community. The forestry law enforcement approach which now is running failed to capture the mastermind of illegal logging. But, the money laundering law enforcement approach which with …

Problem Of Human Rights In World Politics: Three Indonesian Case Studies, Aleksis Jemadu

Indonesian Journal of International Law

The problems of human rights in the global political arena makes the interaction between the actors, even it is a state or non-state after the end of the cold war. In this article, the perspective of international and domestic is used to discuss the extent of the human rights affect those actors. In an international perspective, the emerging of global terrorism threat is start by the September 11th 2001 accident whose be the new challenge for the promotion of human rights because the dominant states will feature the domestic security and international instead of the honor of the human rights. …

Characterization Of Metabolic Gene Expression In The Raw 264.7 Monocyte Cell Line, Lauren Macaisa

PANDION: The Osprey Journal of Research and Ideas

Immune cells undergo changes in gene expression and metabolism when activated by a foreign molecule. Although the changes are short-lived in response to an acute infection, they persist in disorders with underlying chronic inflammation. To understand how changes in gene expression relate to changes in metabolism, the expression of metabolic transporter proteins, was analyzed in response to chronic inflammation in a mouse monocyte cell line. Specifically, Glucose Transporter-1 (GLUT1), Monocarboxylate Transporter-1 (MCT1), Monocarboxylate Transporter-4 (MCT4), and Glutamate Aspartate Transporter (GLAST) were analyzed, and it was hypothesized that all the transporters would increase in expression in response to a prolonged inflammatory …

Nuclear Displacement: Effects Of America's Nuclear Tests On Pacific Islanders, Jessica Faucher

PANDION: The Osprey Journal of Research and Ideas

The United States conducted a series of nuclear tests in the Pacific that permanently displaced Marshall Islanders, specifically the indigenous population of Bikini Atoll. In addition to rendering their native environment uninhabitable, the U.S. used the bodies of the Rongelapese that they exposed to radioactive fallout as a living laboratory to study the effects of radiation. Nuclear Displacement in the Pacific has not received very much attention in historical scholarship, but nevertheless represents a well documented case of imperialism in U.S. History.

Thermal Properties Of 18f-Fdg Uptake And Imaging In Positron Emission Tomography Scans Of Cancerous Cells, Carleigh R. Eagle

PANDION: The Osprey Journal of Research and Ideas

Positron Emission Tomography (PET) scans can utilize a radioactive tracer, in this case 2-deoxy2-[fluorine-18] fluoro-D-glucose (¹⁸F-FDG), to visualize malignant tumors in cancer patients. The uptake was compared to glucose to understand the difference in thermal properties, which contribute to the ability to image the cancerous cells. The uptake of ¹⁸F-FDG by cancer cells and the imaging process of positron emission tomography were reviewed from a thermodynamic perspective. Gastrointestinal and neurological imaging techniques were reviewed to understand the role of PET imaging in different areas of the human body.

Embodied Injustices: Covid-19, Race, And Epigenetics, Maria Encinosa

PANDION: The Osprey Journal of Research and Ideas

The co-occurrence of the COVID-19 pandemic with the long-lasting effects of systemic racism has been devastating, and results in vast inequities in infection and mortality rates within communities of color. In this article, I analyze the potential for epigenetic research to operationalize the social science theory of embodiment, which describes how the social and material worlds manifest in our physical bodies. Epigenetic modifications can be triggered by environmental stressors, to which minority populations are more likely to be exposed. In turn, these stressors are linked to disorders that increase COVID-19 susceptibility. Thus, epigenetic modifications provide an avenue by which racialized …

Tdp-43 Liquid-Liquid Phase Separation (Llps) Deficiency Attenuates Amyloid Beta Deposition In The 5xfad Transgenic Mouse Model Of Alzheimer's Disease, Nathan Ramachandran, Xiaojia Ren, Ju Gao, Luwen Wang, Ariele Peters, Justin Dunn, Xinglong Wang

Posters: 2021 Summer Undergraduate Research Program

Background: TAR DNA-binding protein 43 (TDP-43) can be found within the cell nucleus in most tissues and is a fundamental component to protein production, as it works to slice and reconfigure mRNA molecules. Recently, TDP-43 inclusions have been identified as a prevalent proteinopathy in the brains of individuals diagnosed with Alzheimer's Disease (AD). However, despite the growing body of evidence demonstrating the important role of TDP-43 in AD pathogenesis, whether and how TDP-43 proteinopathy and other AD pathological hallmarks interact remain largely unknown. Furthermore, TDP-43 has a high propensity to undergo liquid-liquid phase separation (LLPS), a biological process necessary for …

Urban Orchard Ecosystem Services In Louisville, Sophie Steppe, Julia Kachanova, Sarah Emery Phd

Undergraduate Research Events

Urban greenspaces are understudied habitats that may provide a variety of ecosystem services not found in other greenspaces.

The aim of this study was to quantify ecosystem services provided by fruit trees in urban orchards in Louisville, KY.

Systematic Review Of Preclinical Surgical Meshes For Hernia Repair, Andrew Hedstrom, Nathan Bills, Cynthia M. Schmidt, Mark A. Carlson

Posters: 2021 Summer Undergraduate Research Program

Hernia repair is one of the most common procedures performed around the world. Surgical mesh materials are used to reinforce hernia repairs and improve surgical outcomes. However, current commercial mesh materials produce problems such as infection, rejection, shrinkage, adhesion, and mechanical failure. These problems contribute to a high rate of hernia recurrence and mesh removal. With the number of hernias expected to rise in the future due to increases in obesity and diabetes, the need for more effective mesh materials is critical. This review aims to identify, evaluate, and summarize experimental surgical mesh materials used in the preclinical stages of …

Temporal And Spatial Variations In Three-Dimensional Seismic Oceanography, Zheguang Zou, Parsa Bakhtiari Rad, Leonardo Macelloni, Likun Zhang

Faculty and Student Publications

Seismic oceanography is a new cross-discipline between geophysics and oceanography that uses seismic reflection data to image and study the oceanic water column. Previous work on seismic oceanography was largely limited to two-dimensional (2D) seismic data and methods. Here we explore and quantify temporal and spatial variations in three-dimensional (3D) seismic oceanography to address whether 3D seismic imaging is meaningful in all directions and how one can take advantage of the variations. From a 3D multichannel seismic survey acquired for oil and gas exploration in the Gulf of Mexico over a 6-month period, a 3D oceanic seismic volume was derived. …

Environment Protection And Public Policies: The Case Of The Brazilian System Of Protected Areas (Snuc), Wainesten Da Silva

International Programs

This poster aims to present the Brazilian System of Protected Areas (SNUC), which is the result of the enforcement of the Brazilian society in promoting public policies to reduce the impact of human activity in nature. It has presented the concept of a public policy, a short history of public policies regarding the environment in Brazil, the main points of the Brazilian System of Protected Areas (SNUC), and a map exposing the protected areas in Brazil. The main finding is that the SNUC is a strong instrument to promote public policies to protect the environment, not only excluding the use …

3. Ou College Of Pharmacy Update, Southwestern Oklahoma State University

SWOSU/OU 2021 Joint Preceptor Conference Handouts

This is a document from the SWOSU/OU 2021 Joint Preceptor Conference

Skeletal Muscle Cell Growth Alters The Lipid Composition Of Extracellular Vesicles, Taylor R. Valentino, Blake D. Rule, C Brooks Mobley, Mariana Nikolova-Karakashian, Ivan Jose Vechetti Jr

Department of Nutrition and Health Sciences: Faculty Publications

We sought to characterize the lipid profile of skeletal muscle cell-derived Extracellular Vesicles (EVs) to determine if a hypertrophic stimulus would affect the lipid composition of C2C12 myotube-derived EVs. Analyses included C2C12 murine myoblasts differentiated into myotubes and treated with Insulin-Like Growth Factor 1 (IGF-1) for 24 h to induce hypertrophic growth. EVs were isolated from cell culture media, quantified using Nanoparticle Tracking Analysis (NTA) and analyzed using Transmission Electron Microscopy (TEM). EVs were homogenized and lipids extracted for quantification by Mass Spectrometry followed by downstream lipid class enrichment and lipid chain analysis. IGF-1 treatment elicited an increase in CD63 …

Multisystem Inflammatory Syndrome In Children - Characteristics, Therapies, And Outcomes, Reid A. Sindelar, Anji Yetman, Jean A. Ballweg

Posters: 2021 Summer Undergraduate Research Program

Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition characterized by severe organ system inflammation and shock, presenting approximately 4-6 weeks after infection with the virus SARS-CoV-2. This disease was first identified in April 2020 and appears to be one of the most severe forms of disease associated with COVID-19 in children. A single-center retrospective study was performed on a cohort of patients diagnosed with MIS-C at Children's Hospital and Medical Center in Omaha. A variety of data--including patient demographics, hospital course, treatments, and long-term cardiac outcomes--were analyzed to better understand MIS-C as an emerging disease.

The Role Of Paf1/Pd2 In Inducing Drug Resistance In Pancreatic Cancer Cells, Aditi Jain, Sanchita Rauth, Surinder K. Batra, Moorthy P. Ponnusamy

Posters: 2021 Summer Undergraduate Research Program

Pancreatic cancer is a highly aggressive human cancer and the third leading cause of death due to cancer. Cancer stems cells (CSC) are a small population of cancer cells that mediate tumorigenesis, metastasis, and resistance to standard treatments. By specifically identifying and targeting CSC maintenance genes, the efficiency of treatment modalities can be improved. PAF1 (RNA Polymerase II-Associated Factor 1), also known as PD2 (Pancreatic Differentiation 2) maintains pluripotency of stem cells and is a marker of pancreatic cancer stem cells. It is upregulated in poorly differentiated pancreatic cancer cells. Gemcitabine is a novel deoxycytidine analogue which has been developed …

Role Of Oocyte-Specific Ckit On Development Of Ovarian Reserve, Amelia L. Podolny, Yi Luan, So-Youn Kim Phd

Posters: 2021 Summer Undergraduate Research Program

Many chemotherapy drugs cause female infertility by permanently shutting down the ovaries. In pre-pubescent girls, this can also result in abnormal sexual development. It is known that many of these harmful chemotherapy drugs bind to cKIT receptors throughout the body. cKIT receptors exist in particularly high concentrations in the ovaries and when they are blocked by chemotherapy drugs, premature ovarian failure results. Our experiment uses a transgenic mouse model to evaluate the effects of cKIT receptors on oocyte formation and development. This experiment is part of a larger effort to understand the mechanisms by which chemotherapy drugs cause premature ovarian …

Updating And Validating The Rheumatic Disease Comorbidity Index To Icd-10-Cm, Hanifah Ali, Punyasha Roul, Yangyuna Yang, Kaleb Michaud, Ted R. Mikuls, Bryant England

Posters: 2021 Summer Undergraduate Research Program

Background/Objective: Comorbidities can contribute to increased risk for mortality and disability in individuals with rheumatoid arthritis (RA)^1,2. The Rheumatic Disease Comorbidity Index (RDCI) assesses 11 comorbidities and produces a weighted score (0-9) that accurately predicts several health outcomes³. The RDCI was developed with self-report data and later validated with ICD-9-CM codes collected from administrative data^3,4. On October 1, 2015, the U.S. transitioned to ICD-10-CM, resulting in a nearly five-fold increase in the number of codes available to classify conditions⁵. Our objective was to update the RDCI by translating it into ICD-10-CM.

Methods: …

Evaluation Of Foxm1 Inhibitor (Fdi-6) As A Potential Therapeutic Molecule For Small Cell Lung Cancer, Aida J. Mohammed, Parvez Khan, Mahek Fatima, Jawed A. Siddiqui, Shailendra K. Maurya, Surinder K. Batra, Mohd W. Nasser

Posters: 2021 Summer Undergraduate Research Program

Lung cancer is the leading cause of cancer deaths accounting for about 22% of all cancer related cases in both males and females. Lung cancers are broadly grouped into two types mainly small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) with SCLC accounting for about 15% of all lung cancer cases. SCLC is different from NSCLC because in most cases it originates centrally in the bronchi and is frequently seen in smokers. SCLC is aggressive and one of the most malignant forms of tumor characterized by uncontrolled rapid growth of certain cells in the lungs. SCLC displays …

Phosphatidylethanolamine N-Methyltransferase (Pemt) Knockout Mice Exhibit Worse Alcohol-Induced Liver Injury Than Wildtype Mice, Ireland M. Murphy, Matthew C. Paal, Srinivas Chava, Madan Kumar Arumugam, Kusum K. Kharbanda

Posters: 2021 Summer Undergraduate Research Program

Phosphatidylethanolamine N-methyltransferase (PEMT) is an enzyme that catalyzes the successive transfer of 3 methyl groups from S-adenosylmethionine (SAM) to phosphatidylethanolamine (PE) to generate phosphatidylcholine (PC). PC is vital for exporting fat out of the liver, ultimately preventing hepatic steatosis. Alcohol also induces steatosis partly through damaging this pathway, so the purpose of this study was to investigate the relationship between alcohol and PEMT in the liver. PEMT -/- (KO) and wild-type (WT) mice were subjected to a chronic + binge alcohol treatment, and both serum and liver samples were analyzed. Triglyceride quantification, SAM and S-adenosylhomocysteine (SAH) levels, and histological analyses …

Intensity-Dependent Changes In Quantified Resting Cerebral Perfusion With Multiple Sessions Of Transcranial Dc Stimulation, Matthew Sherwood, Lindsey Mcintire, Aaron T. Madaris, Kamin Kim, Charan Ranganath, R. Andy Mckinley

Neuroscience, Cell Biology & Physiology Faculty Publications

Transcranial direct current stimulation (tDCS) to the left prefrontal cortex has been shown to produce broad behavioral effects including enhanced learning and vigilance. Still, the neural mechanisms underlying such effects are not fully understood. Furthermore, the neural underpinnings of repeated stimulation remain understudied. In this work, we evaluated the effects of the repetition and intensity of tDCS on cerebral perfusion [cerebral blood flow (CBF)]. A cohort of 47 subjects was randomly assigned to one of the three groups. tDCS of 1- or 2-mA was applied to the left prefrontal cortex on three consecutive days, and resting CBF was quantified before …

Factors That Impact Outcome In Patients Post-Esophagectomy, Leona Jakupi

Theses and Graduate Projects

Background: Esophageal malignancy and severe benign esophageal disorders are now treated by esophagectomy. Although mortality rates after esophagectomy have progressively decreased, many patients continue to suffer from increasing problems despite advances in patient selection, surgical techniques, and postoperative care. The purpose of this research is to determine the perioperative variables that affect morbidity and mortality after esophagectomy.

Methods: A thorough search of Google Scholar, UpToDate, and the Lindell Library was conducted to find previously published papers describing the different outcomes related to esophagectomy. This research consulted a total of 30 reviews and two publications. The esophagus’s architecture, perioperative evaluations, surgical …